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The Perioperative Comparative Evolution of Surgical Stress Markers in Colorectal Cancer Patients Between Classical and Laparoscopic Surgery 结直肠癌经典手术与腹腔镜手术围手术期手术应激标志物的比较演变
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0072
Erika Bimbo-Szuhai, A. Maghiar, M. Botea, A. Huniadi, M. Șandor, Corina Beiușan, I. Macovei, Claudia Teodora Judea Pusta
Abstract Multiple biological parameters were proposed to evaluate the surgical stress response in the early postoperative period. Granulocyte/lymphocyte (G/L) ratio may be a useful marker and widely available. Measuring some of known surgical stress related markers together with G/L ratio we tried to confirm the superiority of laparoscopic approach and efficiency of the G/L ratio monitoring in this period. Materials and methods: 52 colorectal cancer patients who underwent elective surgery in a private clinical hospital were evaluated preoperatively and postoperatively (day 1 and day 5) for the: TNF-α, cortisol, C reactive protein (CRP) and G/L ratio. Results: Only CRP levels were significantly lower in the laparoscopy group in day 1 (74.07 vs 50.32, p=0.0461) and day 5 (18.37 vs 7.32, p=0.0001). The G/L ratio showed strong correlation with CRP levels in all measurements. Conclusions: Measurement of postoperative CRP levels confirmed the reduced surgical stress of laparoscopic colectomy for colorectal cancer in our clinic.
摘要提出了多种生物学参数来评估术后早期的手术应激反应。粒细胞/淋巴细胞(G/L)比率可能是一个有用的标记,并且广泛可用。通过测量一些已知的手术应力相关标志物以及G/L比率,我们试图证实腹腔镜入路的优越性和该时期G/L比率监测的有效性。材料和方法:对52例在私立临床医院接受择期手术的癌症患者术前和术后(第1天和第5天)的TNF-α、皮质醇、C反应蛋白(CRP)和G/L比值进行评估。结果:腹腔镜组在第1天(74.07 vs 50.32,p=0.0461)和第5天(18.37 vs 7.32,p=0.0001)只有CRP水平显著降低。在所有测量中,G/L比与CRP水平呈强相关性。结论:术后CRP水平的测定证实了腹腔镜癌症结肠切除术减轻了手术压力。
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引用次数: 0
Complementary and Innovative Method in Genital HPV Testing for Cervical Cancer Prevention 生殖器官HPV检测预防宫颈癌的补充和创新方法
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0073
Georgeta Gînfălean
Abstract Considering actual SARS-COV 2 pandemic, the comfort and time of the female patient’ trend is to minimize the time spent in the doctor’s office, so that auto-testing is a solving problem in this context. This paper aims at the importance of self-collected urine and vaginal samples, since actual studies are showing that is a complementary method in HPV-testing and a screening method for prevention of cervical cancer. Genital HPV infection is responsible for approximately 99% of cervical cancers, and is considered a sexually transmitted disease. Given that eight out of ten patients have at least one episode of HPV infection in their lifetime, there is a need for a method of early detection of genital HPV infection. Cervical cancer is the second type of diagnosed cancer in the rank of genital cancers and the third leading cause of cancer death among the female population. In Romania, the frequency of cervical cancer and mortality caused by this type of cancer remains high. In 2018 Globocan, it was mentioned that the occurrence of cervical cancer in Romania was 8.6%, and the mortality was 19.5/10,000 women. Worldwide, the following have been implemented: primary prevention programmes (via immunization) and secondary prevention programmes – traditional cytological testing, to which co-tests have been added. In the co-testing sector, there has been found with an updated visa – the self-harvesting test, being considered a complementary and innovative method in genital HPV testing, which aims to: identify the presence of highly oncogenic HPV strains with a marked sensitivity. Self-harvesting testing aims to: signal the presence of highly oncogenic strains, extrapolation can lead to early identification of the number of cases of precancerous lesions of the cervix and implicitly of cervical cancer.
考虑到实际的SARS-COV大流行,女性患者的舒适度和时间趋势是尽量减少在医生办公室的时间,因此自动检测是这一背景下的解决问题。本文的目的是为了说明自采尿液和阴道样本的重要性,因为实际研究表明,这是hpv检测的补充方法,也是预防宫颈癌的筛查方法。生殖器HPV感染导致约99%的宫颈癌,被认为是一种性传播疾病。鉴于十分之八的患者在其一生中至少有一次HPV感染,因此需要一种早期检测生殖器HPV感染的方法。宫颈癌是生殖器官癌症中第二类确诊癌症,也是女性癌症死亡的第三大原因。在罗马尼亚,宫颈癌的发病率和这种癌症造成的死亡率仍然很高。2018年Globocan中提到,罗马尼亚宫颈癌的发病率为8.6%,死亡率为19.5/ 10000名妇女。在世界范围内,实施了以下措施:一级预防规划(通过免疫接种)和二级预防规划——传统细胞学检测,并增加了联合检测。在联合检测领域,已经发现了一种更新的签证-自我收集测试,被认为是生殖器HPV检测的补充和创新方法,其目的是:识别具有显著敏感性的高致癌性HPV菌株的存在。自我收集检测的目的是:提示高致癌性菌株的存在,外推可导致早期识别子宫颈癌前病变病例的数量,并隐含子宫颈癌。
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引用次数: 0
Pediatric Atopic Dermatitis: Update on the Treatment Options 儿童特应性皮炎:最新的治疗方案
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0075
C. Zah, Andreea Emiliana Toporău, Paul Grama
Abstract Atopic dermatitis (AD) is a chronic inflammatory disease characterized by skin dryness, pruritus and eczematous lesions with various periods of relapse. Symptomatology can appear in childhood and can persist in adulthood. Chronic treatment is required with corticosteroids being the standard options. The side effects of this type of long-term treatment represent a major concern for the pediatric patients. This review aims to give an update of the options used for treatment, apart from the systemic corticosteroids. Mild-to-moderate AD had a good response to creams containing fig and oatmeal extracts and inhibitors of phosphodiesterase-4 (crisaborole). In cases of severe AD, future treatment options could include monoclonal antibodies such as omalizumab and dupilumab
摘要特应性皮炎(AD)是一种以皮肤干燥、瘙痒和湿疹样病变为特征的慢性炎症性疾病,并伴有不同时期的复发。症状可能出现在儿童时期,并可能持续到成年。慢性治疗需要皮质类固醇作为标准选择。这种类型的长期治疗的副作用代表了儿科患者的主要担忧。本综述旨在更新除全身皮质类固醇外的治疗方案。轻度至中度AD对含有无花果和燕麦提取物以及磷酸二酯酶-4抑制剂(crisaborole)的乳膏有良好的反应。在严重AD的病例中,未来的治疗选择可能包括单克隆抗体,如奥马珠单抗和杜匹单抗
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引用次数: 1
Clinical and Evolutive Features in Syphilis - HIV Coinfection 梅毒-艾滋病合并感染的临床和进化特征
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0060
G. Iancu, Liliana Elena Todan, M. Rotaru
Abstract Syphilis is a systemic infection caused by Treponema Pallidum spirochete, which is considered to be the main sexually transmitted disease. The genital ulcerations and local inflammation found in syphilis are favouring factors involved in transmitting the HIV infection. Recent data suggests that individuals suffering from other sexually transmitted diseases are 3 to 5 times more exposed to developing HIV infection. On the other hand, simultaneous HIV infection may worsen the syphilis evolution. In the light of this data we present the case of a patient with syphilis-HIV coinfection recently diagnosed and we will summarize the clinical and evolutive features of the syphilis-HIV coinfection.
摘要梅毒是由梅毒螺旋体引起的系统性感染,是主要的性传播疾病。梅毒中发现的生殖器溃疡和局部炎症是传播HIV感染的有利因素。最近的数据表明,患有其他性传播疾病的人感染艾滋病毒的几率是其他人的3到5倍。另一方面,同时感染艾滋病毒可能会恶化梅毒的进化。根据这些数据,我们介绍了最近诊断出的一例梅毒-艾滋病合并感染患者,我们将总结梅毒-艾滋病联合感染的临床和进化特征。
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引用次数: 0
Etiological Considerations Regarding Transmission Hearing Loss 传导性听力损失的病因学考虑
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0062
Mihaela Chialda
Abstract The paper is a retrospective clinical-statistical study on patients diagnosed with pathologies that associate transmission hearing loss in order to obtain data on the etiological considerations of transmission hearing loss, its frequency and predisposition.
摘要本文对被诊断为传播性听力损失相关疾病的患者进行了回顾性临床统计研究,以获得有关传播性听力丧失的病因、频率和易感性的数据。
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引用次数: 0
The Specialization Institute in Dentistry from Bucharest: 1928-1948 布加勒斯特牙科专业研究所:1928-1948年
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0079
M. Burlibașa, M. Perieanu, Claudia-Camelia Burcea, R. Costea, V. Perieanu, C. Ionescu, Iuliana Babiuc, ioana-Cristina neagoe, Raluca Costea, A. Mihai, M. Dina, M. Malița, G. Tanase, E. Marcov, M. Chirilă
Abstract The Specialization Institute in Dentistry (Dental Clinic), both the one that operated in Colțea Hospital and especially the one that operated in Colentina Hospital, both in Bucharest, the capital of Romania, were the first such higher education units in dentistry from Romania, they are in fact the vanguard of the future faculties of dentistry established in our country according to the Soviet model, in 1948. Thus, in this material we tried to highlight some of the most important moments in the existence of those reference units of dental education, period 1928-1948.
摘要牙科专业化研究所(牙科诊所),既在Colțea医院运营,也特别是在罗马尼亚首都布加勒斯特的Colentina医院运营,是罗马尼亚第一个这样的牙科高等教育单位,事实上,他们是我国1948年按照苏联模式建立的未来牙科学院的先锋。因此,在这篇材料中,我们试图强调1928-1948年间牙科教育参考单位存在的一些最重要的时刻。
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引用次数: 0
Acute Mastoiditis - Beginning of COVID-19 Infection - Case Report 急性乳突炎- COVID-19感染的开始-病例报告
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0064
Mihaela Chialda
Abstract Particular onset of Sars-Cov-2 infection, by acute mastoiditis without symptoms specific to the case definition. Mastoiditis is part of inflammatory diseases of the middle ear and is important because of its frequency and life-threatening complications due to the close relationship between the middle ear and the cranial cavity. An acute middle ear inflammation may follow a serious course even if the tympanic membrane does not perforate. In the pathogenesis of acute suppurations of the middle ear, the Eustachian tube plays a major role in the appearance of inflammation and the development of the disease. The most common germ can be - a virus whose initial effect is congestion of mucosa and reduce resistance to biological defence by promoting rapid superinfection with Hemophilus Pneumococcus, Staphylococcus, and others. Sars-Cov-2 infection begins with respiratory phenomena and clinical and biological inflammatory syndrome. This article presents a case of Sars-Cov-2 infection with atypical onset of acute mastoiditis. The clinical importance lies in the fact that the virus can migrate from the nose and nasopharynx through its Eustachian tube into the middle ear and from here to the mastoid. The presence of the virus in the middle ear is almost constant even if the patient is asymptomatic. This requires precautions in all surgical maneuvers at this level in patients with Sars-Cov-2 infection.
特殊发病的Sars-Cov-2感染,由急性乳突炎引起,无特定病例定义的症状。乳突炎是中耳炎症性疾病的一部分,由于中耳与颅腔的密切关系,其发病率高,并发症危及生命,因此具有重要意义。即使鼓膜没有穿孔,急性中耳炎症也可能伴随严重的病程。在中耳急性化脓的发病机制中,耳咽管在炎症的出现和疾病的发展中起着重要作用。最常见的细菌可能是一种病毒,其最初的作用是粘膜充血,通过促进嗜血杆菌肺炎球菌、葡萄球菌和其他细菌的快速重复感染,降低对生物防御的抵抗力。Sars-Cov-2感染始于呼吸道现象以及临床和生物炎症综合征。本文报告1例Sars-Cov-2感染伴急性乳突炎的非典型发病。临床的重要性在于病毒可以从鼻子和鼻咽部通过咽鼓管进入中耳,再从这里进入乳突。即使患者无症状,病毒在中耳的存在几乎是不变的。这需要在Sars-Cov-2感染患者的所有手术操作中采取预防措施。
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引用次数: 0
Risk Factors Regarding Portal Vein Thrombosis in Chronic Liver Disease 慢性肝病门静脉血栓形成的危险因素
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0068
Liliana Vecerzan, R. Mihăilă
Abstract The portal vein thrombosis (PVT) is one of the most frequent vascular diseases of the liver, with a high rate of morbidity and mortality. The most common causes of the PVT are hepatic cirrhosis, hepatobiliary neoplasms, inflammatory and infectious abdominal diseases, and myeloproliferative syndromes.(1,2) The natural progress of the PVT has as a result portal hypertension which leads to splenomegaly and the formation of portosystemic collateral vessels, as well as gastroesophageal, duodenal and jejunal varices. Ultrasonography, especially Doppler ultrasound, is the most widely used imaging method to asses, supervise and diagnose PVT in patients with hepatopathies. The purpose of acute PVT treatment is to re-permeabilize the obstructed vessels; the endoscopic ligature of the varices in the eventuality of their rupture is safe and extremely efficient in chronic PVT. To conclude, PVT is the most common hepatic vascular disorder, and its prevalence has increased particularly among the patients with chronic hepatopathies.(3)
摘要门静脉血栓形成(PVT)是肝脏最常见的血管性疾病之一,发病率和死亡率较高。PVT最常见的病因是肝硬化、肝胆肿瘤、炎症和感染性腹部疾病以及骨髓增生综合征。(1,2)PVT的自然进展导致门静脉高压,导致脾肿大和门体侧支血管的形成,以及胃食管、十二指肠和空肠静脉曲张。超声,尤其是多普勒超声,是评估、监测和诊断肝病患者PVT最广泛使用的成像方法。急性PVT治疗的目的是使阻塞的血管重新透化;在静脉曲张破裂的情况下,内镜下结扎静脉曲张对慢性PVT是安全且非常有效的。总之,PVT是最常见的肝血管疾病,其发病率增加,尤其是在慢性肝病患者中。(3)
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引用次数: 0
Incomplete Kawasaki Disease: What Can We Do About It? 不完全性川崎病:我们能做些什么?
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0074
L. Dobrotă, C. Cazan, D. Bratu, B. Neamțu
Abstract Kawasaki disease is a rare condition that mainly affects children younger than 6 years old. However, it represents the most common cause of acquired heart disease and the second most frequent vasculitis in children. Its importance consists in cardiac (coronary) complications identified in adults younger than 40 years old. Early diagnosis is pivotal for preventing (or reducing) coronary aneurysms and avoiding, at least, later unnecessary surgical interventions. Full (classic, complete) Kawasaki disease is easily diagnosed, even if the symptoms are not always present at the same time and most of them are unspecific. Incomplete Kawasaki disease implies challenge, delay or misdiagnosis. “Picking it up early is a winner” – the specialists say, so that early treatment administered at the right moment can stop the inflammatory process leading to much better outcomes, consequently.
摘要川崎病是一种罕见的疾病,主要影响6岁以下儿童。然而,它是获得性心脏病的最常见原因,也是儿童中第二常见的血管炎。它的重要性在于在40岁以下的成年人中发现心脏(冠状动脉)并发症。早期诊断是预防(或减少)冠状动脉瘤的关键,至少可以避免以后不必要的手术干预。完全(典型的,完全的)川崎病很容易诊断,即使症状并不总是同时出现,而且大多数症状是不特异性的。不完全川崎病意味着挑战、延误或误诊。专家们说:“早发现是赢家”,因此在适当的时候进行早期治疗可以阻止炎症过程,从而带来更好的结果。
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引用次数: 0
Psychological Characteristics of Patients with Diabetes 糖尿病患者的心理特征
Pub Date : 2020-12-01 DOI: 10.2478/amtsb-2020-0057
Annamária Pápai, M. Cozma, Lucica Emilia Coșa, A. Mihai
Abstract The aim of this study is to establish the psychological characteristics of patients with diabetes. In the present study we included subjects with diabetes (n=60), and control group (n=62). In order to study the psychological characteristics of patients with diabetes, we have applied the following tests: Zuckerman-Kuhlman Personality Questionnaire (ZKPQ), Strategic Approach to Coping Scale (SACS), Cognitive Emotion Regulation Questionnaire (CERQ), Young Schema Questionnaire (YSQ-S3), Attitudes and Beliefs Scale (ABS II). The results of this study outlined psychological characteristics of patients with diabetes which consists of neurotic, anxious personality with a high level of activity, dysfunctional coping strategies like: indirect action, antisocial action, aggressive action and catastrophizing, irrational thinking and few maladaptive cognitive patterns. The study highlighted the need to restructure the maladaptive cognitive schemes, irrational beliefs, dysfunctional coping strategies for people with diabetes with a psychological program in order to improve endocrine symptoms and increase quality of life.
摘要本研究的目的是建立糖尿病患者的心理特征。在本研究中,我们纳入了糖尿病受试者(n=60)和对照组(n=62)。为了研究糖尿病患者的心理特征,我们采用了Zuckerman-Kuhlman人格问卷(ZKPQ)、应对策略量表(SACS)、认知情绪调节问卷(CERQ)、青年图式问卷(YSQ-S3)、态度和信念量表(ABSII)。这项研究的结果概述了糖尿病患者的心理特征,包括神经质、焦虑的个性和高水平的活动,功能失调的应对策略,如:间接行动、反社会行动、攻击性行动和灾难性行为,非理性思维和少数不适应的认知模式。这项研究强调,有必要通过心理计划重组糖尿病患者适应不良的认知方案、非理性的信念和功能失调的应对策略,以改善内分泌症状,提高生活质量。
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引用次数: 0
期刊
Acta Medica Transilvanica
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