Pub Date : 2024-11-13DOI: 10.1016/j.ad.2024.09.019
V Peris-Espino, M Munera-Campos, P Chicharro, A Gonzalez Quesada, A Florez Menendez, P de la Cueva Dobao, A M Gimenez Arnau, Y Gilaberte Calzada, M Rodriguez Serna, T Montero-Vilchez, J F Silvestre Salvador, R Ruiz-Villaverde, M Elosua-Gonzalez, E Del Alcázar-Viladomiu, J Sánchez-Pérez, G Carretero Hernández, A Batalla, H J Suh Oh, C Couselo-Rodríguez, C Mauleón Fernández, L Curto-Barredo, M Bertolín-Colilla, A Navarro-Bielsa, A Ballano Ruiz, R Botella Estrada, S Arias-Santiago, R Sanabria-de-la-Torre, I Betlloch-Mas, F J Navarro-Triviño, G Roustan Gullón, A Rosell-Díaz, M Loro-Pérez, J Suárez-Perez, I García-Doval, M Á Descalzo-Gallego, J M Carrascosa Carrillo
Background: Despite advances made in treatments for atopic dermatitis (AD), information on its impact and interaction with atopic comorbidities, such as asthma, rhinoconjunctivitis, and ocular disease is limited. This study aims to assess the clinical-epidemiological characteristics of patients with AD-treatment response included-while taking into consideration atopic comorbidities like these.
Materials and methods: Data were analyzed from the multicenter BIOBADATOP registry (a prospective cohort of AD patients initiating systemic treatment). We conducted a descriptive analysis of the main characteristics collected in the registry in relation to atopic comorbidity.
Results: We included a total of 509 patients, mostly adults (81.9%) with severe AD (73.7%). Patients with personal atopic comorbidity (64%) more frequently exhibited flexural dermatitis (89.7% vs 81.5%), a higher mean of previous systemic treatments (1.6 vs 1.3), and higher baseline values on the POEM scale (19.6 vs 17.9). Patients with familial atopic comorbidity (40.7%) had a higher incidence of pediatric/adolescent patients (24.2% vs 13.9%) and a history of allergic rhinoconjunctivitis (61.1% vs 47.1%). No differences regarding treatment response were observed at the 6- and 12-month follow-ups based on the presence or absence of atopic comorbidities.
Conclusions: Results suggest that a history of atopic comorbidity is associated with an early onset and persistent course of AD. Although no differences were reported in the short-term treatment response, further follow-up is required to better understand the impact of comorbidities on AD.
背景:尽管特应性皮炎(AD)的治疗取得了进展,但有关其与特应性合并症(如哮喘、鼻结膜炎和眼部疾病)的影响和相互作用的信息却很有限。本研究旨在评估过敏性皮炎患者的临床流行病学特征(包括治疗反应),同时考虑到上述特应性合并症:我们对多中心 BIOBADATOP 登记(开始系统治疗的 AD 患者的前瞻性队列)中的数据进行了分析。我们对登记中收集的与特应性合并症相关的主要特征进行了描述性分析:我们共纳入了 509 名患者,其中大部分为成人(81.9%),重度 AD 患者(73.7%)。个人特应性合并症患者(64%)更多表现为屈曲性皮炎(89.7% 对 81.5%),既往接受过系统治疗的平均比例更高(1.6 对 1.3),POEM 量表的基线值更高(19.6 对 17.9)。有家族特应性合并症的患者(40.7%)中,儿童/青少年患者(24.2% 对 13.9%)和有过敏性鼻结膜炎病史的患者(61.1% 对 47.1%)发病率较高。在6个月和12个月的随访中,没有观察到特应性合并症存在与否导致的治疗反应差异:结论:研究结果表明,特应性合并症与AD的早期发病和持续病程有关。虽然短期治疗反应没有差异,但仍需进一步随访,以更好地了解合并症对AD的影响。
{"title":"Clinical-epidemiological profile, and treatment response in relation to associated atopic comorbidity in atopic dermatitis. Experience from the BIOBADATOP Registry.","authors":"V Peris-Espino, M Munera-Campos, P Chicharro, A Gonzalez Quesada, A Florez Menendez, P de la Cueva Dobao, A M Gimenez Arnau, Y Gilaberte Calzada, M Rodriguez Serna, T Montero-Vilchez, J F Silvestre Salvador, R Ruiz-Villaverde, M Elosua-Gonzalez, E Del Alcázar-Viladomiu, J Sánchez-Pérez, G Carretero Hernández, A Batalla, H J Suh Oh, C Couselo-Rodríguez, C Mauleón Fernández, L Curto-Barredo, M Bertolín-Colilla, A Navarro-Bielsa, A Ballano Ruiz, R Botella Estrada, S Arias-Santiago, R Sanabria-de-la-Torre, I Betlloch-Mas, F J Navarro-Triviño, G Roustan Gullón, A Rosell-Díaz, M Loro-Pérez, J Suárez-Perez, I García-Doval, M Á Descalzo-Gallego, J M Carrascosa Carrillo","doi":"10.1016/j.ad.2024.09.019","DOIUrl":"https://doi.org/10.1016/j.ad.2024.09.019","url":null,"abstract":"<p><strong>Background: </strong>Despite advances made in treatments for atopic dermatitis (AD), information on its impact and interaction with atopic comorbidities, such as asthma, rhinoconjunctivitis, and ocular disease is limited. This study aims to assess the clinical-epidemiological characteristics of patients with AD-treatment response included-while taking into consideration atopic comorbidities like these.</p><p><strong>Materials and methods: </strong>Data were analyzed from the multicenter BIOBADATOP registry (a prospective cohort of AD patients initiating systemic treatment). We conducted a descriptive analysis of the main characteristics collected in the registry in relation to atopic comorbidity.</p><p><strong>Results: </strong>We included a total of 509 patients, mostly adults (81.9%) with severe AD (73.7%). Patients with personal atopic comorbidity (64%) more frequently exhibited flexural dermatitis (89.7% vs 81.5%), a higher mean of previous systemic treatments (1.6 vs 1.3), and higher baseline values on the POEM scale (19.6 vs 17.9). Patients with familial atopic comorbidity (40.7%) had a higher incidence of pediatric/adolescent patients (24.2% vs 13.9%) and a history of allergic rhinoconjunctivitis (61.1% vs 47.1%). No differences regarding treatment response were observed at the 6- and 12-month follow-ups based on the presence or absence of atopic comorbidities.</p><p><strong>Conclusions: </strong>Results suggest that a history of atopic comorbidity is associated with an early onset and persistent course of AD. Although no differences were reported in the short-term treatment response, further follow-up is required to better understand the impact of comorbidities on AD.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1016/j.ad.2023.10.055
A Gómez-Zubiaur, A Rodríguez-Villa, D Vega-Diez, J M Ricart
{"title":"Psychological outcomes after hair transplant in women with androgenetic alopecia.","authors":"A Gómez-Zubiaur, A Rodríguez-Villa, D Vega-Diez, J M Ricart","doi":"10.1016/j.ad.2023.10.055","DOIUrl":"https://doi.org/10.1016/j.ad.2023.10.055","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1016/j.ad.2023.09.032
A Muñiz de Lucas, R Gamo Villegas, M Uxúa Floristan Muruzabal
{"title":"Reflectance confocal microscopy in desmoplastic melanoma.","authors":"A Muñiz de Lucas, R Gamo Villegas, M Uxúa Floristan Muruzabal","doi":"10.1016/j.ad.2023.09.032","DOIUrl":"https://doi.org/10.1016/j.ad.2023.09.032","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1016/j.ad.2024.09.020
G Sanclemente, C Mora, D C Aguirre
Background and aims: Previous results of the Dermatology-Life-Quality-Index (DLQI) validation in Colombia based on the classical test theory (CTT) perspective have showed the need to delve into its measurement properties. Therefore, we aimed to assess the structural validity, internal consistency and item response analysis of the DLQI through the item response theory (IRT) or the Rasch model.
Material and methods: We assessed the dimensionality of the DLQI, determined its difficulty, discrimination and differential functioning and went on to evaluate its internal consistency and discriminative validity among patients with inflammatory and non-inflammatory skin disease. We recruited Colombian patients with different skin diseases.
Results: Data of 865 patients (mean age, 49.3 years; 61% females) were included. DLQI-scores ranged from 0 up to 30. Internal consistency for dichotomous item #7 showed a McDonald's Omega coefficient of 0.85 (95%CI, 0.84-0.87) and a Cronbach's α coefficient of 0.86 (95%CI, 0.84-0.88). For ordinal item #7, the McDonald's Omega coefficient was 0.87 (95%IC:0.85-0.89) and Cronbach's α coefficient, 0.84 (95%CI, 0.82-0.87). Horn's parallel analysis revealed the presence of DLQI unidimensionality with a 1-factor solution. Only item #1 fitted the PCM model. The remaining items, including item #9, did not show adequate fit due to overlapping responses and order changes.
Conclusions: The validity of DLQI-COL based on Rasch analysis proved not to be a suitable instrument to evaluate QoL in our dermatologic population. A refined version of the scale with an adequate cross-cultural adaptation and validation process is needed to obtain an appropriate and reliable version of the instrument for QOL measuring in Colombian patients with skin diseases.
{"title":"Rasch Analysis Of The Dermatology Life Quality Index.","authors":"G Sanclemente, C Mora, D C Aguirre","doi":"10.1016/j.ad.2024.09.020","DOIUrl":"https://doi.org/10.1016/j.ad.2024.09.020","url":null,"abstract":"<p><strong>Background and aims: </strong>Previous results of the Dermatology-Life-Quality-Index (DLQI) validation in Colombia based on the classical test theory (CTT) perspective have showed the need to delve into its measurement properties. Therefore, we aimed to assess the structural validity, internal consistency and item response analysis of the DLQI through the item response theory (IRT) or the Rasch model.</p><p><strong>Material and methods: </strong>We assessed the dimensionality of the DLQI, determined its difficulty, discrimination and differential functioning and went on to evaluate its internal consistency and discriminative validity among patients with inflammatory and non-inflammatory skin disease. We recruited Colombian patients with different skin diseases.</p><p><strong>Results: </strong>Data of 865 patients (mean age, 49.3 years; 61% females) were included. DLQI-scores ranged from 0 up to 30. Internal consistency for dichotomous item #7 showed a McDonald's Omega coefficient of 0.85 (95%CI, 0.84-0.87) and a Cronbach's α coefficient of 0.86 (95%CI, 0.84-0.88). For ordinal item #7, the McDonald's Omega coefficient was 0.87 (95%IC:0.85-0.89) and Cronbach's α coefficient, 0.84 (95%CI, 0.82-0.87). Horn's parallel analysis revealed the presence of DLQI unidimensionality with a 1-factor solution. Only item #1 fitted the PCM model. The remaining items, including item #9, did not show adequate fit due to overlapping responses and order changes.</p><p><strong>Conclusions: </strong>The validity of DLQI-COL based on Rasch analysis proved not to be a suitable instrument to evaluate QoL in our dermatologic population. A refined version of the scale with an adequate cross-cultural adaptation and validation process is needed to obtain an appropriate and reliable version of the instrument for QOL measuring in Colombian patients with skin diseases.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1016/j.ad.2024.04.030
Celia Requena, E Sánchez-Romero, E Nagore, O Sanmartín
{"title":"Paraneoplastic dermatomyositis: a 25-patient series from a cancer center.","authors":"Celia Requena, E Sánchez-Romero, E Nagore, O Sanmartín","doi":"10.1016/j.ad.2024.04.030","DOIUrl":"https://doi.org/10.1016/j.ad.2024.04.030","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2023.10.054
M Fabregat-Pratdepadua, V Mora Fernández, J Verdaguer-Faja, J Bassas Vila
Although comedones are a prevalent entity in multiple skin diseases, their perianal location as a cluster is a rare finding. We describe 5 patients with grouped perianal comedones who developed the lesions in adulthood and were treatment-naïve in the perianal area. Four of them had had inflammatory lesions in armpits and groins. In 2, the anatomopathological examination revealed the presence of follicular infundibulum dilatation, cystification, and fibrotic and inflammatory changes in the underlying dermis-findings consistent with hidradenitis suppurativa-which is why we wonder whether grouped perianal comedones are a mild form of hidradenitis suppurativa or an isolated entity.
{"title":"Perianal comedones: a variant of hidradenitis suppurativa or an isolated entity? Five-case report.","authors":"M Fabregat-Pratdepadua, V Mora Fernández, J Verdaguer-Faja, J Bassas Vila","doi":"10.1016/j.ad.2023.10.054","DOIUrl":"https://doi.org/10.1016/j.ad.2023.10.054","url":null,"abstract":"<p><p>Although comedones are a prevalent entity in multiple skin diseases, their perianal location as a cluster is a rare finding. We describe 5 patients with grouped perianal comedones who developed the lesions in adulthood and were treatment-naïve in the perianal area. Four of them had had inflammatory lesions in armpits and groins. In 2, the anatomopathological examination revealed the presence of follicular infundibulum dilatation, cystification, and fibrotic and inflammatory changes in the underlying dermis-findings consistent with hidradenitis suppurativa-which is why we wonder whether grouped perianal comedones are a mild form of hidradenitis suppurativa or an isolated entity.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2024.04.029
E Lucía Pinto-Pulido, E García-Verdú, D Vega-Díez
{"title":"RF- Un update on the management of alopecia areata.","authors":"E Lucía Pinto-Pulido, E García-Verdú, D Vega-Díez","doi":"10.1016/j.ad.2024.04.029","DOIUrl":"https://doi.org/10.1016/j.ad.2024.04.029","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2024.01.026
P C Luna, R A Pérez-Córdova, M E Abad, A Almassio, N Atamari-Anahui, M Larralde
{"title":"Clinical-epidemiological characteristics and treatment of palmoplantar psoriasis in Argentine children.","authors":"P C Luna, R A Pérez-Córdova, M E Abad, A Almassio, N Atamari-Anahui, M Larralde","doi":"10.1016/j.ad.2024.01.026","DOIUrl":"10.1016/j.ad.2024.01.026","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2024.05.029
C Pindado-Ortega, R Pirmez, D Fernandes Melo, L Junqueira Fortes Binato, M L Porriño-Bustamante, J Barreto Carpi, R Gil-Redondo, Á Hermosa-Gelbard, J Jiménez-Cauhé, D Saceda-Corralo, S Vaño-Galván
The objective of our study was to analyze the effectiveness of oral minoxidil on the frontotemporal hairline in patients with FFA. We conducted a retrospective, descriptive, multicenter study in 2 Brazilian and 1 Spanish centers. Responses were graded on a scale of 3 positive points. A total of 122 patients were included. Subjective improvement in the density of the frontotemporal hairline was observed in 45.1% patients, which was categorized as mild (34.4%), moderate (9.0%), and excellent (1.6%). Hair density improved in 57.4% of the patients' interparietal. Additionally, 25.4% and 3.3% of the patients experienced eyebrow and eyelash growth, respectively. Adverse effects were detected in 33.6% patients, with hypertrichosis being the most common (23.8%). In this study, oral minoxidil proved to be an additional therapy for FFA that not only improved the patients' overall hair and eyebrow growth, but also the density of the frontotemporal hairline.
{"title":"Low-dose oral minoxidil for frontal fibrosing alopecia: a 122-patient case series.","authors":"C Pindado-Ortega, R Pirmez, D Fernandes Melo, L Junqueira Fortes Binato, M L Porriño-Bustamante, J Barreto Carpi, R Gil-Redondo, Á Hermosa-Gelbard, J Jiménez-Cauhé, D Saceda-Corralo, S Vaño-Galván","doi":"10.1016/j.ad.2024.05.029","DOIUrl":"10.1016/j.ad.2024.05.029","url":null,"abstract":"<p><p>The objective of our study was to analyze the effectiveness of oral minoxidil on the frontotemporal hairline in patients with FFA. We conducted a retrospective, descriptive, multicenter study in 2 Brazilian and 1 Spanish centers. Responses were graded on a scale of 3 positive points. A total of 122 patients were included. Subjective improvement in the density of the frontotemporal hairline was observed in 45.1% patients, which was categorized as mild (34.4%), moderate (9.0%), and excellent (1.6%). Hair density improved in 57.4% of the patients' interparietal. Additionally, 25.4% and 3.3% of the patients experienced eyebrow and eyelash growth, respectively. Adverse effects were detected in 33.6% patients, with hypertrichosis being the most common (23.8%). In this study, oral minoxidil proved to be an additional therapy for FFA that not only improved the patients' overall hair and eyebrow growth, but also the density of the frontotemporal hairline.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2023.10.053
R F Pombar, N Torres, M V Centeno, A B Cervini
{"title":"Congenital vascular tumor.","authors":"R F Pombar, N Torres, M V Centeno, A B Cervini","doi":"10.1016/j.ad.2023.10.053","DOIUrl":"https://doi.org/10.1016/j.ad.2023.10.053","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}