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Clinical-epidemiological profile, and treatment response in relation to associated atopic comorbidity in atopic dermatitis. Experience from the BIOBADATOP Registry. 特应性皮炎患者的临床流行病学特征以及治疗反应与相关特应性合并症的关系。来自 BIOBADATOP 登记处的经验。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-13 DOI: 10.1016/j.ad.2024.09.019
V Peris-Espino, M Munera-Campos, P Chicharro, A Gonzalez Quesada, A Florez Menendez, P de la Cueva Dobao, A M Gimenez Arnau, Y Gilaberte Calzada, M Rodriguez Serna, T Montero-Vilchez, J F Silvestre Salvador, R Ruiz-Villaverde, M Elosua-Gonzalez, E Del Alcázar-Viladomiu, J Sánchez-Pérez, G Carretero Hernández, A Batalla, H J Suh Oh, C Couselo-Rodríguez, C Mauleón Fernández, L Curto-Barredo, M Bertolín-Colilla, A Navarro-Bielsa, A Ballano Ruiz, R Botella Estrada, S Arias-Santiago, R Sanabria-de-la-Torre, I Betlloch-Mas, F J Navarro-Triviño, G Roustan Gullón, A Rosell-Díaz, M Loro-Pérez, J Suárez-Perez, I García-Doval, M Á Descalzo-Gallego, J M Carrascosa Carrillo

Background: Despite advances made in treatments for atopic dermatitis (AD), information on its impact and interaction with atopic comorbidities, such as asthma, rhinoconjunctivitis, and ocular disease is limited. This study aims to assess the clinical-epidemiological characteristics of patients with AD-treatment response included-while taking into consideration atopic comorbidities like these.

Materials and methods: Data were analyzed from the multicenter BIOBADATOP registry (a prospective cohort of AD patients initiating systemic treatment). We conducted a descriptive analysis of the main characteristics collected in the registry in relation to atopic comorbidity.

Results: We included a total of 509 patients, mostly adults (81.9%) with severe AD (73.7%). Patients with personal atopic comorbidity (64%) more frequently exhibited flexural dermatitis (89.7% vs 81.5%), a higher mean of previous systemic treatments (1.6 vs 1.3), and higher baseline values on the POEM scale (19.6 vs 17.9). Patients with familial atopic comorbidity (40.7%) had a higher incidence of pediatric/adolescent patients (24.2% vs 13.9%) and a history of allergic rhinoconjunctivitis (61.1% vs 47.1%). No differences regarding treatment response were observed at the 6- and 12-month follow-ups based on the presence or absence of atopic comorbidities.

Conclusions: Results suggest that a history of atopic comorbidity is associated with an early onset and persistent course of AD. Although no differences were reported in the short-term treatment response, further follow-up is required to better understand the impact of comorbidities on AD.

背景:尽管特应性皮炎(AD)的治疗取得了进展,但有关其与特应性合并症(如哮喘、鼻结膜炎和眼部疾病)的影响和相互作用的信息却很有限。本研究旨在评估过敏性皮炎患者的临床流行病学特征(包括治疗反应),同时考虑到上述特应性合并症:我们对多中心 BIOBADATOP 登记(开始系统治疗的 AD 患者的前瞻性队列)中的数据进行了分析。我们对登记中收集的与特应性合并症相关的主要特征进行了描述性分析:我们共纳入了 509 名患者,其中大部分为成人(81.9%),重度 AD 患者(73.7%)。个人特应性合并症患者(64%)更多表现为屈曲性皮炎(89.7% 对 81.5%),既往接受过系统治疗的平均比例更高(1.6 对 1.3),POEM 量表的基线值更高(19.6 对 17.9)。有家族特应性合并症的患者(40.7%)中,儿童/青少年患者(24.2% 对 13.9%)和有过敏性鼻结膜炎病史的患者(61.1% 对 47.1%)发病率较高。在6个月和12个月的随访中,没有观察到特应性合并症存在与否导致的治疗反应差异:结论:研究结果表明,特应性合并症与AD的早期发病和持续病程有关。虽然短期治疗反应没有差异,但仍需进一步随访,以更好地了解合并症对AD的影响。
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引用次数: 0
Psychological outcomes after hair transplant in women with androgenetic alopecia. 雄激素性脱发妇女植发后的心理结果。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-13 DOI: 10.1016/j.ad.2023.10.055
A Gómez-Zubiaur, A Rodríguez-Villa, D Vega-Diez, J M Ricart
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引用次数: 0
Reflectance confocal microscopy in desmoplastic melanoma. 脱鳞黑色素瘤中的反射共聚焦显微镜。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-13 DOI: 10.1016/j.ad.2023.09.032
A Muñiz de Lucas, R Gamo Villegas, M Uxúa Floristan Muruzabal
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引用次数: 0
Rasch Analysis Of The Dermatology Life Quality Index. 皮肤科生活质量指数的拉氏分析。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-13 DOI: 10.1016/j.ad.2024.09.020
G Sanclemente, C Mora, D C Aguirre

Background and aims: Previous results of the Dermatology-Life-Quality-Index (DLQI) validation in Colombia based on the classical test theory (CTT) perspective have showed the need to delve into its measurement properties. Therefore, we aimed to assess the structural validity, internal consistency and item response analysis of the DLQI through the item response theory (IRT) or the Rasch model.

Material and methods: We assessed the dimensionality of the DLQI, determined its difficulty, discrimination and differential functioning and went on to evaluate its internal consistency and discriminative validity among patients with inflammatory and non-inflammatory skin disease. We recruited Colombian patients with different skin diseases.

Results: Data of 865 patients (mean age, 49.3 years; 61% females) were included. DLQI-scores ranged from 0 up to 30. Internal consistency for dichotomous item #7 showed a McDonald's Omega coefficient of 0.85 (95%CI, 0.84-0.87) and a Cronbach's α coefficient of 0.86 (95%CI, 0.84-0.88). For ordinal item #7, the McDonald's Omega coefficient was 0.87 (95%IC:0.85-0.89) and Cronbach's α coefficient, 0.84 (95%CI, 0.82-0.87). Horn's parallel analysis revealed the presence of DLQI unidimensionality with a 1-factor solution. Only item #1 fitted the PCM model. The remaining items, including item #9, did not show adequate fit due to overlapping responses and order changes.

Conclusions: The validity of DLQI-COL based on Rasch analysis proved not to be a suitable instrument to evaluate QoL in our dermatologic population. A refined version of the scale with an adequate cross-cultural adaptation and validation process is needed to obtain an appropriate and reliable version of the instrument for QOL measuring in Colombian patients with skin diseases.

背景和目的:之前基于经典测验理论(CTT)在哥伦比亚进行的皮肤病学-生活质量指数(DLQI)验证结果表明,有必要深入研究其测量特性。因此,我们旨在通过项目反应理论(IRT)或 Rasch 模型评估 DLQI 的结构效度、内部一致性和项目反应分析:我们评估了 DLQI 的维度,确定了其难度、区分度和差异功能,然后评估了其在炎症性和非炎症性皮肤病患者中的内部一致性和区分有效性。我们招募了患有不同皮肤病的哥伦比亚患者:结果:纳入了 865 名患者(平均年龄 49.3 岁;61% 为女性)的数据。DLQI分值从0到30不等。二分项目 7 的内部一致性显示,麦克唐纳欧米茄系数为 0.85(95%CI,0.84-0.87),克朗巴赫α系数为 0.86(95%CI,0.84-0.88)。对于序数项目 7,麦克唐纳的欧米茄系数为 0.87(95%CI:0.85-0.89),克朗巴赫的 α 系数为 0.84(95%CI:0.82-0.87)。霍恩平行分析显示,DLQI 存在单因素单维性。只有第 1 项符合 PCM 模型。包括第 9 项在内的其余项目由于回答重叠和顺序变化而没有显示出足够的拟合度:结论:基于 Rasch 分析的 DLQI-COL 的有效性被证明不适合用于评估皮肤病患者的 QoL。需要对该量表进行适当的跨文化调整和验证,以获得一个合适、可靠的量表版本,用于测量哥伦比亚皮肤病患者的 QOL。
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引用次数: 0
Paraneoplastic dermatomyositis: a 25-patient series from a cancer center. 副肿瘤性皮肌炎:来自一家癌症中心的 25 例患者。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-13 DOI: 10.1016/j.ad.2024.04.030
Celia Requena, E Sánchez-Romero, E Nagore, O Sanmartín
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引用次数: 0
Perianal comedones: a variant of hidradenitis suppurativa or an isolated entity? Five-case report. 肛周粉刺:化脓性扁桃体炎的一种变体还是一种独立的实体?五例报告。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-12 DOI: 10.1016/j.ad.2023.10.054
M Fabregat-Pratdepadua, V Mora Fernández, J Verdaguer-Faja, J Bassas Vila

Although comedones are a prevalent entity in multiple skin diseases, their perianal location as a cluster is a rare finding. We describe 5 patients with grouped perianal comedones who developed the lesions in adulthood and were treatment-naïve in the perianal area. Four of them had had inflammatory lesions in armpits and groins. In 2, the anatomopathological examination revealed the presence of follicular infundibulum dilatation, cystification, and fibrotic and inflammatory changes in the underlying dermis-findings consistent with hidradenitis suppurativa-which is why we wonder whether grouped perianal comedones are a mild form of hidradenitis suppurativa or an isolated entity.

尽管粉刺是多种皮肤病中的一种常见病,但其在肛周的群发位置却很少见。我们描述了 5 位肛周聚集性粉刺患者,他们都是在成年后出现的病变,而且肛周部位没有接受过治疗。其中四人的腋窝和腹股沟曾有过炎症病变。其中 2 例患者的解剖病理学检查显示,毛囊基底扩张、囊肿化、真皮下纤维化和炎症性改变--这些发现与化脓性扁桃体炎一致--因此我们不禁要问,肛周成群的粉刺是化脓性扁桃体炎的一种轻微形式,还是一种独立的实体。
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引用次数: 0
RF- Un update on the management of alopecia areata. RF- 关于斑秃治疗的最新进展。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-12 DOI: 10.1016/j.ad.2024.04.029
E Lucía Pinto-Pulido, E García-Verdú, D Vega-Díez
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引用次数: 0
Clinical-epidemiological characteristics and treatment of palmoplantar psoriasis in Argentine children. 阿根廷儿童掌跖银屑病的临床流行病学特征和治疗方法。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-12 DOI: 10.1016/j.ad.2024.01.026
P C Luna, R A Pérez-Córdova, M E Abad, A Almassio, N Atamari-Anahui, M Larralde
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引用次数: 0
Low-dose oral minoxidil for frontal fibrosing alopecia: a 122-patient case series. 小剂量米诺地尔口服液治疗额部纤维性脱发:122 例病例系列研究。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-12 DOI: 10.1016/j.ad.2024.05.029
C Pindado-Ortega, R Pirmez, D Fernandes Melo, L Junqueira Fortes Binato, M L Porriño-Bustamante, J Barreto Carpi, R Gil-Redondo, Á Hermosa-Gelbard, J Jiménez-Cauhé, D Saceda-Corralo, S Vaño-Galván

The objective of our study was to analyze the effectiveness of oral minoxidil on the frontotemporal hairline in patients with FFA. We conducted a retrospective, descriptive, multicenter study in 2 Brazilian and 1 Spanish centers. Responses were graded on a scale of 3 positive points. A total of 122 patients were included. Subjective improvement in the density of the frontotemporal hairline was observed in 45.1% patients, which was categorized as mild (34.4%), moderate (9.0%), and excellent (1.6%). Hair density improved in 57.4% of the patients' interparietal. Additionally, 25.4% and 3.3% of the patients experienced eyebrow and eyelash growth, respectively. Adverse effects were detected in 33.6% patients, with hypertrichosis being the most common (23.8%). In this study, oral minoxidil proved to be an additional therapy for FFA that not only improved the patients' overall hair and eyebrow growth, but also the density of the frontotemporal hairline.

我们的研究旨在分析口服米诺地尔对前额颞发际线患者的疗效。我们在巴西的两个中心和西班牙的一个中心进行了一项回顾性、描述性、多中心研究。研究结果以 3 个阳性点进行评分。共纳入了 122 名患者。45.1%的患者主观感觉额颞部发际密度有所改善,分为轻度(34.4%)、中度(9.0%)和极好(1.6%)。57.4%的患者顶叶间的头发密度有所改善。此外,分别有 25.4% 和 3.3% 的患者出现眉毛和睫毛生长。33.6%的患者出现了不良反应,其中最常见的是多毛症(23.8%)。在这项研究中,口服米诺地尔被证明是治疗前颞叶脱发的一种额外疗法,它不仅能改善患者的整体头发和眉毛生长情况,还能改善前颞叶发际线的密度。
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引用次数: 0
Congenital vascular tumor. 先天性血管肿瘤
IF 3.8 Q1 DERMATOLOGY Pub Date : 2024-11-12 DOI: 10.1016/j.ad.2023.10.053
R F Pombar, N Torres, M V Centeno, A B Cervini
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引用次数: 0
期刊
Actas dermo-sifiliograficas
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