Pub Date : 2025-12-18DOI: 10.1016/j.ad.2025.104585
L. Ferrándiz , J.A. Heras-Hitos , P. Casas Rodríguez , A. Valcarce-Leonisio , O. San Martín , R. Ruiz-Villaverde
Actinic keratosis is a skin disease with the potential to progress to cutaneous squamous cell carcinoma, making its treatment essential. However, the last update of the Spanish adaptation of the European clinical guidelines dates back to 2014. This document includes the recommendations agreed upon by 75 primary care and dermatology experts on the optimal management of patients with actinic keratosis. In general, early and detailed diagnosis of actinic keratosis using dermoscopy and referral to dermatology is recommended, especially in high-risk patients. Regarding treatment, experts recommend the use of treatments adapted to the degree and extent of the injuries, highlighting the use of molecules such as 5-fluorouracil for isolated and field of cancerization injuries, as well as tirbanibulin for grade 1 and 2 isolated and field of cancerization injuries. These consensual recommendations seek to serve as a clinical guide on the routine management of patients with actinic keratosis.
{"title":"Multidisciplinary Delphi Consensus Between Primary Care and Dermatology on Updated Management of Actinic Keratosis in Spain","authors":"L. Ferrándiz , J.A. Heras-Hitos , P. Casas Rodríguez , A. Valcarce-Leonisio , O. San Martín , R. Ruiz-Villaverde","doi":"10.1016/j.ad.2025.104585","DOIUrl":"10.1016/j.ad.2025.104585","url":null,"abstract":"<div><div>Actinic keratosis is a skin disease with the potential to progress to cutaneous squamous cell carcinoma, making its treatment essential. However, the last update of the Spanish adaptation of the European clinical guidelines dates back to 2014. This document includes the recommendations agreed upon by 75 primary care and dermatology experts on the optimal management of patients with actinic keratosis. In general, early and detailed diagnosis of actinic keratosis using dermoscopy and referral to dermatology is recommended, especially in high-risk patients. Regarding treatment, experts recommend the use of treatments adapted to the degree and extent of the injuries, highlighting the use of molecules such as 5-fluorouracil for isolated and field of cancerization injuries, as well as tirbanibulin for grade 1 and 2 isolated and field of cancerization injuries. These consensual recommendations seek to serve as a clinical guide on the routine management of patients with actinic keratosis.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 2","pages":"Article 104585"},"PeriodicalIF":2.8,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.ad.2025.104580
B. Rebollo Caballero , S. Mallo García , B. Ocaña Castillo
{"title":"Persistent Erythema and Thickening of the Nasal Skin","authors":"B. Rebollo Caballero , S. Mallo García , B. Ocaña Castillo","doi":"10.1016/j.ad.2025.104580","DOIUrl":"10.1016/j.ad.2025.104580","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104580"},"PeriodicalIF":2.8,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.ad.2025.104579
L. Schneller-Pavelescu , C. Mora-Martínez , M.J. Sánchez-Pujol , Y. Sanz , E. Caparrós-Cayuela , R. Francés-Guarinos , J.M. Ramos-Rincón , I. Belinchón-Romero
Background
The gut microbiota interacts with the immune system and plays an important role in many inflammatory diseases such as psoriasis, although the exact mechanisms in this disease are not yet well understood.
Objectives
To characterize differences in the microbiota between patients with psoriasis and healthy controls, and to assess the relationship between these differences and the interleukins involved in psoriasis.
Methods
A cross-sectional observational study was conducted in which sociodemographic data, blood samples, and stool samples were collected from patients with psoriasis and healthy controls attending our center between June 2019 and May 2020. Cytokines (interleukin (IL) 17, 22, 23, 31, 33, 36, interferon (IFN) γ, and transforming growth factor (TGF) β) were analyzed using ELISA, and microbiota was analyzed through 16S amplicon sequencing.
Results
Thirty-six patients and 24 controls were included. Absolute abundance analysis found a higher abundance of the phylum Synergistota in the control group (p < 0.05). Differential abundance analysis found higher abundance of the genus Subdoligranulum and Lactobacillus, and the species Bacteroides plebeius (p < 0.05), and lower abundance of the species Senegalimassilia anaerobia and the genus Ruminococcus (p < 0.05) in the psoriasis group. A relationship was observed between Subdoligranulum and TNFα, IL17, IL22, IL23, IL31, IL33, IL36, IFNγ, and TGFβ (p < 0.05), as well as between Lactobacillus and IL17, IL23, IL36, TNFα, and TGFβ (p < 0.05).
Conclusions
Significant alterations in the gut microbiota of patients with psoriasis were detected and a relationship with inflammatory interleukins, suggesting their involvement in the disease. These findings could aid in the development of future probiotic treatments for psoriasis.
{"title":"Relation Between Gut Microbiome and Inflammatory Interleukins in Psoriasis Patients Compared to Healthy Controls: An Observational Study","authors":"L. Schneller-Pavelescu , C. Mora-Martínez , M.J. Sánchez-Pujol , Y. Sanz , E. Caparrós-Cayuela , R. Francés-Guarinos , J.M. Ramos-Rincón , I. Belinchón-Romero","doi":"10.1016/j.ad.2025.104579","DOIUrl":"10.1016/j.ad.2025.104579","url":null,"abstract":"<div><h3>Background</h3><div>The gut microbiota interacts with the immune system and plays an important role in many inflammatory diseases such as psoriasis, although the exact mechanisms in this disease are not yet well understood.</div></div><div><h3>Objectives</h3><div>To characterize differences in the microbiota between patients with psoriasis and healthy controls, and to assess the relationship between these differences and the interleukins involved in psoriasis.</div></div><div><h3>Methods</h3><div>A cross-sectional observational study was conducted in which sociodemographic data, blood samples, and stool samples were collected from patients with psoriasis and healthy controls attending our center between June 2019 and May 2020. Cytokines (interleukin (IL) 17, 22, 23, 31, 33, 36, interferon (IFN) γ, and transforming growth factor (TGF) β) were analyzed using ELISA, and microbiota was analyzed through 16S amplicon sequencing.</div></div><div><h3>Results</h3><div>Thirty-six patients and 24 controls were included. Absolute abundance analysis found a higher abundance of the phylum Synergistota in the control group (<em>p</em> <!--><<!--> <!-->0.05). Differential abundance analysis found higher abundance of the genus <em>Subdoligranulum</em> and <em>Lactobacillus</em>, and the species <em>Bacteroides plebeius</em> (<em>p</em> <!--><<!--> <!-->0.05), and lower abundance of the species <em>Senegalimassilia anaerobia</em> and the genus <em>Ruminococcus</em> (<em>p</em> <!--><<!--> <!-->0.05) in the psoriasis group. A relationship was observed between <em>Subdoligranulum</em> and TNFα, IL17, IL22, IL23, IL31, IL33, IL36, IFNγ, and TGFβ (<em>p</em> <!--><<!--> <!-->0.05), as well as between <em>Lactobacillus</em> and IL17, IL23, IL36, TNFα, and TGFβ (<em>p</em> <!--><<!--> <!-->0.05).</div></div><div><h3>Conclusions</h3><div>Significant alterations in the gut microbiota of patients with psoriasis were detected and a relationship with inflammatory interleukins, suggesting their involvement in the disease. These findings could aid in the development of future probiotic treatments for psoriasis.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104579"},"PeriodicalIF":2.8,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.ad.2025.104574
J. Romaní
{"title":"A Decade of Biologic Therapy for Hidradenitis Suppurativa: What Have We Achieved?","authors":"J. Romaní","doi":"10.1016/j.ad.2025.104574","DOIUrl":"10.1016/j.ad.2025.104574","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104574"},"PeriodicalIF":2.8,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.ad.2025.104575
T.L. Vega López , L. Aguilar González , R.P. Román Cheuque , D. Jiménez Gallo
{"title":"Linezolid, an Alternative to Ertapenem in Recalcitrant Hidradenitis Suppurativa: A Series of 6 Cases","authors":"T.L. Vega López , L. Aguilar González , R.P. Román Cheuque , D. Jiménez Gallo","doi":"10.1016/j.ad.2025.104575","DOIUrl":"10.1016/j.ad.2025.104575","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104575"},"PeriodicalIF":2.8,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.ad.2025.104577
M.A. Sirvent-Sáez, A.I. Sánchez-Del-Campo, D. Moreno-Ramírez
{"title":"Bilateral Hand Swelling as a Sign of Systemic Amyloidosis","authors":"M.A. Sirvent-Sáez, A.I. Sánchez-Del-Campo, D. Moreno-Ramírez","doi":"10.1016/j.ad.2025.104577","DOIUrl":"10.1016/j.ad.2025.104577","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104577"},"PeriodicalIF":2.8,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.ad.2025.104573
A. García-Mares , E. Conde Montero
{"title":"Traditional Practices in Dermatology and Wound Care: Are They Evidence-Based?","authors":"A. García-Mares , E. Conde Montero","doi":"10.1016/j.ad.2025.104573","DOIUrl":"10.1016/j.ad.2025.104573","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104573"},"PeriodicalIF":2.8,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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