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Actas dermo-sifiliograficas最新文献

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Hypopigmented lesions in a patient with metastatic breast cancer. 转移性乳腺癌患者的色素减退病变。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-09 DOI: 10.1016/j.ad.2025.104534
J F Orts Paco, J P Serrano Serra, B Rebollo Caballero
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引用次数: 0
Unexpected end of a hypochromic macule. 褪色斑的意外结束。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-09 DOI: 10.1016/j.ad.2025.104533
C L Soledad, O Boris, T Jorge
{"title":"Unexpected end of a hypochromic macule.","authors":"C L Soledad, O Boris, T Jorge","doi":"10.1016/j.ad.2025.104533","DOIUrl":"https://doi.org/10.1016/j.ad.2025.104533","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104533"},"PeriodicalIF":2.8,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute phimosis related to Monkeypox. 与猴痘有关的急性包茎病。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-09 DOI: 10.1016/j.ad.2025.104532
C Alonso Diez, Á Aguado Vázquez, P Villodre Lozano, A Estébanez Corrales
{"title":"Acute phimosis related to Monkeypox.","authors":"C Alonso Diez, Á Aguado Vázquez, P Villodre Lozano, A Estébanez Corrales","doi":"10.1016/j.ad.2025.104532","DOIUrl":"https://doi.org/10.1016/j.ad.2025.104532","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104532"},"PeriodicalIF":2.8,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eruptive Verrucous Keratoses and Melanocytic Nevi Induced by Encorafenib Plus Cetuximab in a Patient With Metastatic Colorectal Cancer. 恩科非尼联合西妥昔单抗在转移性结直肠癌患者中诱导爆发性疣状角化病和黑素细胞痣。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-09 DOI: 10.1016/j.ad.2025.104529
A Ferreirinha, P M Garrido, C Moura
{"title":"Eruptive Verrucous Keratoses and Melanocytic Nevi Induced by Encorafenib Plus Cetuximab in a Patient With Metastatic Colorectal Cancer.","authors":"A Ferreirinha, P M Garrido, C Moura","doi":"10.1016/j.ad.2025.104529","DOIUrl":"https://doi.org/10.1016/j.ad.2025.104529","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104529"},"PeriodicalIF":2.8,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ruxolitinib in the treatment of vitiligo. The importance of the JAK STAT pathway. 鲁索利替尼治疗白癜风。JAK STAT通路的重要性。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-08 DOI: 10.1016/j.ad.2025.104543
J L López Estebaranz, G Segurado Miravalles, S Ros Abarca

Vitiligo is a chronic autoimmune disease of multifactorial nature that causes skin depigmentation as a consequence of melanocyte loss. Although sometimes it is said to be untreatable, there are therapies that have succeeded in halting its progression and promoting repigmentation. One of these are inhibitors of the JAK-STAT pathway, which plays a prominent role in the immunopathogenesis of the disease. Ruxolitinib, a JAK 1/2 inhibitor, has been the first topical drug approved for the treatment of vitiligo. This narrative review addresses the immunopathologic processes involved in vitiligo, the role of the JAK-STAT pathway, and the efficacy and safety results of ruxolitinib in the treatment of nonsegmental vitiligo in adult and adolescent patients older than 12 years with facial involvement. In addition, the psychological repercussions and the impact on the quality of life suffered by patients with vitiligo are described.

白癜风是一种多因素的慢性自身免疫性疾病，由于黑素细胞的损失导致皮肤色素沉着。虽然有时它被认为是无法治愈的，但有一些治疗方法已经成功地阻止了它的进展并促进了色素的重新着色。其中之一是JAK-STAT通路的抑制剂，它在疾病的免疫发病机制中起着突出的作用。Ruxolitinib是一种JAK 1/2抑制剂，是第一个被批准用于治疗白癜风的外用药物。本文综述了白癜风的免疫病理过程，JAK-STAT通路的作用，以及鲁索利替尼治疗非节段性白癜风的有效性和安全性结果，这些白癜风患者年龄大于12岁，伴有面部病变。此外，还描述了白癜风患者的心理影响和对生活质量的影响。
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引用次数: 0
Overlap between Psoriasis and Atopic Dermatitis: Therapeutic approach. 银屑病和特应性皮炎的重叠：治疗方法。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-08 DOI: 10.1016/j.ad.2025.104541
F Tous-Romero, C Calvo-Asín
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引用次数: 0
Dermatoscopic findings of adverse nail effects in cancer patients. Observational study of 140 patients. 癌症患者指甲不良反应的皮肤镜检查结果。140例观察性研究。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-08 DOI: 10.1016/j.ad.2025.104540
C Laso-Leizcano, A Gavillero, L Navarro-Campoamor, T García-Lozano, E Nagore

Background: Chemotherapy can cause multiple dermatological alterations, including nail changes that significantly impact patients' quality of life. This study aims to characterize the nail alterations induced by chemotherapy and assess their diagnosis through dermatoscopy.

Methodology: An observational, prospective, and descriptive study that included 140 patients from the Fundación Instituto Valenciano de Oncología (FIVO). Both clinical and dermatoscopic nail alterations in the hands and feet were evaluated, associated with the different chemotherapy drugs administered. Analyzed variables included the type of nail alteration, the treatment cycle in which they appeared, and the observed dermatoscopic patterns.

Results: The prevalence of nail alterations was 45.7%, with chromonychia being the most frequent, followed by onycholysis. Lesions affected both hands and feet in 72.3% of cases. The most common chromonichias were erythronychia (36.4%) and leukonychia (9.3%). Monoclonal antibodies, tubulin binders, and platinum complexes were the drug groups most associated with these alterations. Onychomycosis was suspected in eight patients, confirmed in four cases through mycological cultures, where non-dermatophyte fungi were isolated.

Conclusion: Nail alterations induced by chemotherapy are common, affecting nearly half of patients. Dermatoscopy allowed the identification of alterations at early stages, which can facilitate the implementation of timely therapeutic strategies and improve patients' quality of life.

背景：化疗可引起多种皮肤病变，包括影响患者生活质量的指甲变化。本研究的目的是描述化疗引起的指甲改变，并通过皮肤镜评估其诊断。方法：一项观察性、前瞻性和描述性研究，纳入了Fundación瓦伦西亚诺研究所Oncología （FIVO）的140例患者。临床和皮肤镜下的指甲改变在手和脚进行评估，与不同的化疗药物施用。分析的变量包括指甲改变的类型，它们出现的治疗周期，以及观察到的皮肤镜模式。结果：甲变发生率为45.7%，其中以慢性甲变发生率最高，其次为溶甲。72.3%的病例双手和双脚都有病变。最常见的慢性甲癣是红甲癣（36.4%）和白甲癣（9.3%）。单克隆抗体、微管蛋白结合剂和铂配合物是与这些改变最相关的药物组。8名患者怀疑患有甲真菌病，其中4例通过真菌学培养确诊，其中分离出非皮肤真菌。结论：化疗引起的甲改变是常见的，影响近一半的患者。皮肤镜检查允许在早期阶段识别病变，这可以促进及时实施治疗策略，提高患者的生活质量。
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引用次数: 0
RF - New treatments in dermatomyositis: present and future. 皮肌炎的新治疗方法：现在和未来。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-08 DOI: 10.1016/j.ad.2025.104551
M Mansilla-Polo, P Balado-Simó, J M Mascaró
{"title":"RF - New treatments in dermatomyositis: present and future.","authors":"M Mansilla-Polo, P Balado-Simó, J M Mascaró","doi":"10.1016/j.ad.2025.104551","DOIUrl":"https://doi.org/10.1016/j.ad.2025.104551","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104551"},"PeriodicalIF":2.8,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145720013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous pili migrans. 皮肤毛移位。
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-08 DOI: 10.1016/j.ad.2025.104550
P López Sanz, M E Alfaro Martínez, S Manso Córdoba
{"title":"Cutaneous pili migrans.","authors":"P López Sanz, M E Alfaro Martínez, S Manso Córdoba","doi":"10.1016/j.ad.2025.104550","DOIUrl":"https://doi.org/10.1016/j.ad.2025.104550","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104550"},"PeriodicalIF":2.8,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145720006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tildrakizumab 200 mg. Is double dosing really a window of opportunity? Tildrakizumab 200mg。双倍剂量真的有机会吗？
IF 2.8 Q1 DERMATOLOGY
Actas dermo-sifiliograficas
Pub Date : 2025-12-08 DOI: 10.1016/j.ad.2025.104539
Carlos Llamas-Segura, Marta Cebolla-Verdugo, Ricardo Ruiz-Villaverde
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引用次数: 0
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