Actas dermo-sifiliograficas最新文献

Objective: To study melanoma incidence trends from 1990 to 2021 in Southern European countries-Portugal, Spain, Italy, Greece-and explore regional and age-period-cohort (A-P-C) patterns.

Methods: Data from the Global Burden of Disease Study 2021 were used to calculate age-standardized incidence rates (ASIRs). Joinpoint regression and age-period cohort (A-P-C) models were applied to identify trends and patterns.

Results: A substantial increase in melanoma ASIRs was observed across all Southern European countries from 1990 to 2021. Joinpoint analysis revealed a potential turning point in the 2010s, with ASIRs stabilizing or declining in younger age groups across all countries. For instance, rates among younger women in Italy, Portugal, and Spain have shown signs of stabilization or decline, while Greek women experienced a continued but slower increase. Men exhibited a similar trend, except for Greece, where the increase rate persisted albeit at a slower pace. Gender differences were evident, with younger women generally facing higher risks vs men but exhibiting a slower rise in incidence with age. The A-P-C analysis confirmed a pronounced cohort effect, indicating a higher risk for melanoma among earlier birth cohorts. Among younger generations, there is evidence of stabilization or even a decline in incidence rates.

Conclusion: Melanoma rates are rising in Southern Europe, especially among men. While younger populations show promising declines, likely due to sun protection efforts, older generations continue to be affected. Addressing regional disparities and sustaining these positive trends requires ongoing efforts and comprehensive prevention strategies.

Introduction: Hidradenitis suppurativa (HS) is a skin disease which has a major impact on the patients' quality of life. There are still uncertainties surrounding its epidemiology, natural history and saftety and efficacy profile of existing treatments. The Spanish Academy of Dermatology and Venereology has promoted the creation of a Spanish Registry of patients with HS (REHS). The aim of this article is to present the REHS and give and overview and provide the performance metrics during the initial year.

Methods: The REHS is a prospective, multicenter, observational study that collects the clinical and epidemiological characteristics of patients with HS, and the safety and efficacy profil of the medical and surgical treatments received.

Results: A total of 359 patients were recruited from 23 Spanish centers from June 2023 through June 2024. The patients' mean age was 37 years (53% women). More than 70% of the patients were smokers or ex-smokers. One third had a family history of HS. The most frequent sites of disease onset are the axillae and groin. Median baseline IHS4 at recruitment was 4 (p25-p75=1-9), HiSQOL was 20 (p25-p75=8-36), and BMI was 27.3 (p25-p75=24-33.2). At least, 82% of patients have received antibiotic therapy for their disease, and almost 20% a biologic drug.

Conclusions: We present data from the first patients enrolled in the REHS, which will allow us to generate evidence on the natural course of the disease, and understand the safety and efficacy profile of treatments in HS.

Hidradenitis suppurativa is a chronic inflammatory skin condition characterized by painful nodules, abscesses, and sinus tracts that may lead to irreversible scarring complications. Therapeutic options include antibiotics, biologic therapies, and surgical procedures. Current management of hidradenitis suppurativa favors early surgical intervention along with medical therapy to promote healing and minimize scars and complications in a disease characterized by a therapeutic window of opportunity. Surgical techniques range from incision and drainage to wide excision, with varying recurrence rates mainly based on the extent of procedures. Reconstruction techniques would vary primarily based on the extent of the defect and the area involved. In all cases, a good preoperative planning and delimitation with imaging modalities, preferably intra- or perioperative facilitates complete removal of involved tissue, preserving the integrity and function of healthy skin and minimizing recurrences.