Actas dermo-sifiliograficas最新文献

英文中文

Parental Assessment of Infantile Hemangioma Cosmetic Clinical Outcomes: Results of the Spanish Hemangioma Nationwide Prospective Cohort 父母对婴儿血管瘤美容临床结果的评估：西班牙全国血管瘤前瞻性队列的结果。

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2024.06.010

M. Colmenero-Sendra , J. del Boz-González , E. Baselga Torres , J. Bernabéu-Wittel , E. Roé-Crespo , A. Vicente , M. Valdivieso-Ramos , A. Martín-Santiago , S.I. Palencia-Pérez , M.T. Montserrat-García , A. Azón-Masoliver , M. Dañino , C. Tubau Prims , C. Prat , A. Giacaman , J.J. Domínguez-Cruz , A. Bauzá Alonso , M. Grau-Pérez , M.Á. Descalzo , I. García-Doval

Background

Functional impairment is the main consideration when it comes to choosing therapy for infantile hemangiomas (IH). However, since most hemangiomas are treated for cosmetic reasons, it is important to know the cosmetic outcome assessed by the parents.

Objective

To evaluate the aesthetic outcomes of IH, considering the characteristics of the lesions and the treatments used.

Patients and methods

The Spanish Infantile Hemangioma Nationwide Prospective Cohort (2016–2022) recruited all consecutive patients diagnosed with IH in 12 Spanish hospitals. The children included had two photos of the IH lesion (at both baseline and at the end of the study). A panel of parents blindly assessed all available photos using a scale from 0 (worst cosmetic outcomes) to 10 (best cosmetic outcomes). The different scores – both before and after treatment – as well as the outcomes percent considered excellent (>9) were described and compared. We analyzed the effect of receiving different therapies and performed causal model analyses estimating the mean treatment effect of parents’ assessments.

Results

The median follow-up was 3.1 years. A total of 824 photos were evaluated. Baseline aesthetic impact was higher in the propranolol group vs the topical timolol and observation treatment groups (1.85 vs 3.14 vs 3.66 respectively; p < 0.001). After treatment, the aesthetic impact was similar between both treatment groups (7.59 vs 7.93 vs 7.90; p > 0.2). The causal model could only be applied to the comparison between topical timolol and observation, revealing no differences whatsoever.

Conclusion

This is the first prospective cohort to analyze the aesthetic outcome of IH. The final aesthetic results of the three therapies were similar, with nearly 40% of patients achieving excellent aesthetic outcomes.

背景：在选择婴儿血管瘤（IH）治疗方法时，功能障碍是主要考虑因素。然而，由于大多数血管瘤的治疗都是为了美观，因此了解家长对美观效果的评估非常重要：患者和方法：西班牙婴幼儿血管瘤全国前瞻性队列（2016-2022 年）招募了西班牙 12 家医院所有连续确诊的 IH 患者。被纳入研究的儿童有两张IH病变的照片（在基线和研究结束时）。一个由家长组成的小组采用 0 分（最差的美容效果）至 10 分（最佳的美容效果）的评分标准对所有可用照片进行盲评。我们对治疗前后的不同评分以及认为效果极佳（大于 9 分）的百分比进行了描述和比较。我们分析了接受不同疗法的效果，并对父母评估的平均治疗效果进行了因果模型分析：中位随访时间为 3.1 年。共评估了 824 张照片。普萘洛尔组的基线美观度高于外用噻吗洛尔组和观察治疗组（分别为 1.85 vs 3.14 vs 3.66；P < 0.001）。治疗后，两个治疗组的美观效果相似（7.59 vs 7.93 vs 7.90；p > 0.2）。因果模型仅适用于局部噻吗洛尔与观察组之间的比较，结果显示没有任何差异：结论：这是首个分析 IH 美学效果的前瞻性队列研究。三种疗法的最终美学效果相似，近 40% 的患者获得了极佳的美学效果。

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引用次数: 0

Comedones perianales: ¿una variante de hidradenitis supurativa o una entidad per se? Serie de 5 casos 肛周粉刺：化脓性扁桃体炎的一种变体还是一种独立的实体？五例报告。

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2023.10.054

M. Fabregat-Pratdepadua, V. Mora Fernández, J. Verdaguer-Faja, J. Bassas Vila

Although comedones are a prevalent entity in multiple skin diseases, their perianal location as a cluster is a rare finding. We describe 5 patients with grouped perianal comedones who developed the lesions in adulthood and were treatment-naïve in the perianal area. Four of them had had inflammatory lesions in armpits and groins. In 2, the anatomopathological examination revealed the presence of follicular infundibulum dilatation, cystification, and fibrotic and inflammatory changes in the underlying dermis—findings consistent with hidradenitis suppurativa—which is why we wonder whether grouped perianal comedones are a mild form of hidradenitis suppurativa or an isolated entity.

尽管粉刺是多种皮肤病中的一种常见病，但其在肛周的群发位置却很少见。我们描述了 5 位肛周聚集性粉刺患者，他们都是在成年后出现的病变，而且肛周部位没有接受过治疗。其中四人的腋窝和腹股沟曾有过炎症病变。其中 2 例患者的解剖病理学检查显示，毛囊基底扩张、囊肿化、真皮下纤维化和炎症性改变--这些发现与化脓性扁桃体炎一致--因此我们不禁要问，肛周成群的粉刺是化脓性扁桃体炎的一种轻微形式，还是一种独立的实体。

引用次数: 0

FR - Actualización en el tratamiento de la alopecia areata RF- 关于斑秃治疗的最新进展。

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2024.04.029

E.L. Pinto-Pulido , E. García-Verdú , D. Vega-Díez

引用次数: 0

Terapia compresiva en las heridas de pierna por aumento del espacio de difusión 由于扩散空间增大，腿部溃疡患者可采用压力疗法。

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2024.05.030

B. Gonzalez Rodriguez , L. Calderon Lozano , J. Fulgencio Barbarin , E. Conde Montero

引用次数: 0

Eritema, edema localizado y calor versus aumento del perímetro del antebrazo. ¿Ha llegado el momento de revisar las recomendaciones de consenso de la prueba de provocación del vórtice en urticaria-angioedema vibratorios? 红斑、局部水肿和发热与前臂周长增加。是时候修订振动性荨麻疹-血管性水肿涡流激发试验的共识建议了？

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2024.10.058

M.E. Gatica-Ortega , B. Sánchez-Albisua , D.M. Arranz-Sánchez , B. Pérez-Tato , A. Sánchez-Gilo , S. Córdoba-Guijarro , F.J. Ortiz-Frutos , N. Hernández-Cano , E. Gómez de la Fuente , M. Elosua-González , M. Bergón-Sendín , C. García-Martín , T. Sanz-Sánchez , O. Mazuela-Díez , R. Torres-Aranda , L. Vergara-de-la-Campa , S. Marinero-Escobedo , A. Alegre-Bailo , A. Garrido-Ríos , F. Tous-Romero , M.A. Pastor-Nieto

Background and objective

Diagnosis of vibratory urticaria/angioedema is established after performing the vortex provocation test. There is current consensus on measuring the forearm perimeter after running such test to define a positive response to it.

Material and method

We evaluated the frequency of prior symptoms following vibratory stimuli in volunteers using a questionnaire, response to the vortex provocation test in the same volunteers (increase in forearm perimeter, erythema, localized edema, heat, and pruritus), interrater reliability, and correlation between the scores obtained in the questionnaire and response to the test.

Results

A total of 40 volunteers participated in this survey, 17 of whom were excluded due to dermographism. A total of 59% out of 123 without dermographism responded positively to ≥1 items of the questionnaire. Localized erythema, heat or localized edema were reported in 58.5%, 38.2%, and 32.5%, respectively. A total of 73.6% of volunteers presented with itch. The mean intensity of itch was 3.44, 95%CI: 2.94-3.94). Interrater agreement was low regarding the increase in forearm circumference at 3 levels (intraclass correlation coefficient, 0.477, 95%CI: 0.253-0.634; 0.496, 95%CI: 0.280-0.647; and 0.370, 95%CI: 0.100-0.559, respectively) and optimal regarding erythema, heat and localized edema (Kappa index, 0.868; 0.756; and 0.757, respectively). A significant correlation was identified between the questionnaire score and the altered response to the test in its different variables.

Conclusions

We propose the following variables: erythema; localized edema; heat; and the intensity/speed of onset/duration of pruritus to define a positive response to the vortex provocation test given their ease of execution and optimal inter-observer agreement.

背景和目的：振动性荨麻疹/血管性水肿的诊断是在进行涡流激惹试验后确定的。目前的共识是在进行此类试验后测量前臂周长，以确定对试验的阳性反应：我们使用问卷调查法评估了志愿者在受到振动刺激后出现先前症状的频率、同一志愿者对涡流激惹试验的反应（前臂周长增加、红斑、局部水肿、发热和瘙痒）、评分者之间的可靠性以及问卷调查得分与试验反应之间的相关性：共有 40 名志愿者参加了此次调查，其中 17 人因皮肤划痕症而被排除在外。在 123 名未患有皮肤划痕症的志愿者中，共有 59% 的志愿者对问卷中≥ 1 个项目做出了肯定回答。报告出现局部红斑、发热或局部水肿的比例分别为 58.5%、38.2% 和 32.5%。共有 73.6% 的志愿者出现瘙痒症状。瘙痒的平均强度为 3.44（95%CI，2.94-3.94）。在前臂周长增加的 3 个水平上，相互之间的一致性较低（类内相关系数分别为 0.477 95%CI，0.253-0.634；0.496 95%CI，0.280-0.647；0.370 95%CI，0.100-0.559），而在红斑、发热和局部水肿方面，相互之间的一致性最佳（Kappa 指数分别为 0.868、0.756 和 0.757）。在不同变量中，问卷得分与测试反应的改变之间存在明显的相关性：我们建议使用以下变量：红斑、局部水肿、热度和瘙痒的强度/发作速度/持续时间来定义涡流刺激试验的阳性反应，因为这些变量易于执行，而且观察者之间的一致性最佳。

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引用次数: 0

Acné queloideo de la nuca, un reto terapéutico para los dermatólogos 瘢痕疙瘩：皮肤科医生面临的治疗挑战。

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2024.08.011

L. Ortiz-Lobato , A. Imbernón-Moya , D. Saceda-Corralo , S. Vano-Galvan

Acne keloidalis nuchae (AKN) is a chronic inflammatory dermatosis of the scalp that causes scarring alopecia. The etiology of AKN has been associated with an immune response vs. follicular antigens. AKN is characterized by fibrotic papules and plaques that can converge in tumor-like lesions; subclinical disease has been reported in perilesional areas, which could impact its development. Early diagnosis and treatment are essential to reduce morbidity and preserve and minimize healing. Various treatments have been established including optimal medical therapy, surgical excision, and light sources. An updated description of treatments (algorithm included) used for AKN is suggested based on the clinical lesions.

颈部瘢痕疙瘩（AKN）是一种头皮慢性炎症性皮肤病，可导致瘢痕性脱发。AKN 的病因与毛囊抗原的免疫反应有关。AKN 的特征是纤维化丘疹和斑块，这些丘疹和斑块可汇聚成肿瘤样病变；有报告称，在毛囊周围区域存在亚临床疾病，这可能会影响其发展。早期诊断和治疗对于降低发病率、保护和减少愈合至关重要。目前已经确立了多种治疗方法，包括最佳药物治疗、手术切除和光源治疗。本文根据临床病变，对 AKN 的治疗方法（包括算法）进行了最新描述。

引用次数: 0

[Artículo traducido] Evolución psicológica tras el trasplante capilar en mujeres con alopecia androgénica 女性雄激素性脱发患者植发后的心理结果。

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2025.01.001

A. Gómez-Zubiaur , A. Rodríguez-Villa , D. Vega-Diez , J.M. Ricart

引用次数: 0

[Artículo traducido] Análisis Rasch del índice de calidad de vida en dermatología

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2025.01.006

G. Sanclemente , C. Mora-Gaviria , D.C. Aguirre-Acevedo

Background and aims

Previous results of the Dermatology-Life-Quality-Index (DLQI) validation in Colombia based on the classical test theory (CTT) perspective have showed the need to delve into its measurement properties. Therefore, we aimed to assess the structural validity, internal consistency and item response analysis of the DLQI through the item response theory (IRT) or the Rasch model.

Material and methods

We assessed the dimensionality of the DLQI, determined its difficulty, discrimination and differential functioning and went on to evaluate its internal consistency and discriminative validity among patients with inflammatory and non-inflammatory skin disease. We recruited Colombian patients with different skin diseases.

Results

Data of 865 patients (mean age, 49.3 years; 61% females) were included. DLQI-scores ranged from 0 up to 30. Internal consistency for dichotomous item #7 showed a McDonald's Omega coefficient of 0.85 (95% CI: 0.84-0.87) and a Cronbach's α coefficient of 0.86 (95% CI: 0.84-0.88). For ordinal item #7, the McDonald's Omega coefficient was 0.87 (95% IC: 0.85-0.89) and Cronbach's α coefficient, 0.84 (95% CI: 0.82-0.87). Horn's parallel analysis revealed the presence of DLQI unidimensionality with a 1-factor solution. Only item #1 fitted the PCM model. The remaining items, including item #9, did not show adequate fit due to overlapping responses and order changes.

Conclusions

The validity of DLQI-COL based on Rasch analysis proved not to be a suitable instrument to evaluate QoL in our dermatologic population. A refined version of the scale with an adequate cross-cultural adaptation and validation process is needed to obtain an appropriate and reliable version of the instrument for QOL measuring in Colombian patients with skin diseases.

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引用次数: 0

Patrón arcoíris: potencial clave o distractor en el diagnóstico dermatoscópico 彩虹图案：皮肤镜诊断中的关键潜力或干扰因素。

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2024.06.012

M.E. Alfaro Martínez, P. López Sanz, A. García-Vázquez

引用次数: 0

Perfil clínico, epidemiológico y respuesta al tratamiento, en función de la comorbilidad atópica asociada en la dermatitis atópica. Experiencia del registro BIOBADATOP 特应性皮炎患者的临床流行病学特征以及治疗反应与相关特应性合并症的关系。来自 BIOBADATOP 登记处的经验。

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas

Pub Date : 2025-04-01 DOI: 10.1016/j.ad.2024.09.019

V. Peris-Espino , M. Munera-Campos , P. Chicharro , A. González Quesada , Á. Flórez Menéndez , P. de la Cueva Dobao , A.M. Giménez Arnau , Y. Gilaberte Calzada , M. Rodríguez Serna , T. Montero-Vilchez , J.F. Silvestre Salvador , R. Ruiz-Villaverde , M. Elosua-González , E. del Alcázar-Viladomiu , J. Sánchez-Pérez , G. Carretero Hernández , A. Batalla , H.J. Suh Oh , C. Couselo-Rodríguez , C. Mauleón Fernández , J.M. Carrascosa Carrillo

Background

Despite advances made in treatments for atopic dermatitis (AD), information on its impact and interaction with atopic comorbidities, such as asthma, rhinoconjunctivitis, and ocular disease is limited. This study aims to assess the clinical-epidemiological characteristics of patients with AD—treatment response included—while taking into consideration atopic comorbidities like these.

Materials and methods

Data were analyzed from the multicenter BIOBADATOP registry (a prospective cohort of AD patients initiating systemic treatment). We conducted a descriptive analysis of the main characteristics collected in the registry in relation to atopic comorbidity.

Results

We included a total of 509 patients, mostly adults (81.9%) with severe AD (73.7%). Patients with personal atopic comorbidity (64%) more frequently exhibited flexural dermatitis (89.7% vs 81.5%), a higher mean of previous systemic treatments (1.6 vs. 1.3), and higher baseline values on the POEM scale (19.6 vs. 17.9). Patients with familial atopic comorbidity (40.7%) had a higher incidence of pediatric/adolescent patients (24.2% vs. 13.9%) and a history of allergic rhinoconjunctivitis (61.1% vs. 47.1%). No differences regarding treatment response were observed at the 6- and 12-month follow-ups based on the presence or absence of atopic comorbidities.

Conclusions

Results suggest that a history of atopic comorbidity is associated with an early onset and persistent course of AD. Although no differences were reported in the short-term treatment response, further follow-up is required to better understand the impact of comorbidities on AD.

背景：尽管特应性皮炎（AD）的治疗取得了进展，但有关其与特应性合并症（如哮喘、鼻结膜炎和眼部疾病）的影响和相互作用的信息却很有限。本研究旨在评估过敏性皮炎患者的临床流行病学特征（包括治疗反应），同时考虑到上述特应性合并症：我们对多中心 BIOBADATOP 登记（开始系统治疗的 AD 患者的前瞻性队列）中的数据进行了分析。我们对登记中收集的与特应性合并症相关的主要特征进行了描述性分析：我们共纳入了 509 名患者，其中大部分为成人（81.9%），重度 AD 患者（73.7%）。个人特应性合并症患者（64%）更多表现为屈曲性皮炎（89.7% 对 81.5%），既往接受过系统治疗的平均比例更高（1.6 对 1.3），POEM 量表的基线值更高（19.6 对 17.9）。有家族特应性合并症的患者（40.7%）中，儿童/青少年患者（24.2% 对 13.9%）和有过敏性鼻结膜炎病史的患者（61.1% 对 47.1%）发病率较高。在6个月和12个月的随访中，没有观察到特应性合并症存在与否导致的治疗反应差异：结论：研究结果表明，特应性合并症与AD的早期发病和持续病程有关。虽然短期治疗反应没有差异，但仍需进一步随访，以更好地了解合并症对AD的影响。

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