Pub Date : 2025-03-01DOI: 10.1016/j.ad.2023.08.022
N.M. Román Mendoza , R. Muñoz Martínez , I. Gonzalo González , F.J. Vicente Martín
{"title":"Chemsex y lesiones cutáneas tras la inyección de mefedrona. A propósito de 3 casos","authors":"N.M. Román Mendoza , R. Muñoz Martínez , I. Gonzalo González , F.J. Vicente Martín","doi":"10.1016/j.ad.2023.08.022","DOIUrl":"10.1016/j.ad.2023.08.022","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 3","pages":"Pages 323-325"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.ad.2024.12.006
S. Gomez-Martinez , J. Ibaceta Ayala , D. Morgado-Carrasco
Wood's light (WL) is a useful, economical and easy-to-learn diagnostic tool. Despite its advantages, the use of LW among dermatologists is limited. In porokeratosis, the “diamond necklace” sign has been described, corresponding to the white fluorescence of the hyperkeratotic scale. Subclinical morphea lesions are seen as well-defined dark macules. Among the pigmentary disorders, the bluish fluorescence of vitiligo, the increased contrast of epidermal melasma, and the follicular-centered red fluorescence of progressive macular hypomelanosis stand out. Regarding skin infections, erythrasma presents a coral red fluorescence; tinea versicolor, yellow-green fluorescence; Pseudomonas aeuriginosa, green fluorescence; and scabies, blue-white fluorescence in the acarine burrows. In skin cancer, LW has been used to delimit the surgical margins of both lentigo maligna and non-melanoma skin cancer, with variable results.
{"title":"[Translated article] Wood's Light in Inflammatory and Autoimmune Dermatoses, Infections and Skin Cancer","authors":"S. Gomez-Martinez , J. Ibaceta Ayala , D. Morgado-Carrasco","doi":"10.1016/j.ad.2024.12.006","DOIUrl":"10.1016/j.ad.2024.12.006","url":null,"abstract":"<div><div>Wood's light (WL) is a useful, economical and easy-to-learn diagnostic tool. Despite its advantages, the use of LW among dermatologists is limited. In porokeratosis, the “diamond necklace” sign has been described, corresponding to the white fluorescence of the hyperkeratotic scale. Subclinical morphea lesions are seen as well-defined dark macules. Among the pigmentary disorders, the bluish fluorescence of vitiligo, the increased contrast of epidermal melasma, and the follicular-centered red fluorescence of progressive macular hypomelanosis stand out. Regarding skin infections, erythrasma presents a coral red fluorescence; tinea versicolor, yellow-green fluorescence; <em>Pseudomonas aeuriginosa</em>, green fluorescence; and scabies, blue-white fluorescence in the acarine burrows. In skin cancer, LW has been used to delimit the surgical margins of both lentigo maligna and non-melanoma skin cancer, with variable results.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 3","pages":"Pages T281-T290"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.ad.2024.07.017
E. Samaniego-González , S. Podlipnik , S. Ribero , E. Nagore , A. Boada , J. Cañueto , S. Paradela , B. de Unamuno , P. Rodríguez-Jiménez , S. Puig , J. Malvehy , C. Carrera , G. Roccuzzo , C. Requena , E. Manrique-Silva , N. Richarz , A. Ruiz-Villanueva , V. Traves , S. España-Fernández , R. Botella-Estrada , A. Tejera-Vaquerizo
Introduction
Complete lymph node dissection (CLND) was the standard practice for patients with melanoma and a positive sentinel lymph node biopsy (SLNB) until the results of 2 clinical trials published in 2016 and 2017 demonstrated that it did not improve melanoma-specific survival (MSS). However, it continues to be performed in some scenarios. No studies have ever been published on lymph node management after a positive SLNB in the routine clinical practice in our setting.
Objectives
To determine the evolution of the indication for CLND in patients with a positive SLNB, as well as the characteristics associated with its performance.
Material and methods
We conducted a multicenter retrospective observational study with patients with skin melanoma and positive sentinel lymph nodes diagnosed from 2017 through 2022 at 8 Spanish centers and 1 Italian center.
Results
A total of 430 patients were included, 54% men, with 358 (75.1%) aged between 45 and 80 years. A total of 133 cases (31%) exhibited Breslow thickness > 4 mm, 206 cases (49.1%) were ulcerated, and in 213 cases (55.7%), lymph node metastasis was > 1 mm. Isolated lymphadenectomy or followed by adjuvant therapy was performed in 146 patients (34.1%). After multivariate logistic regression, the factors associated with the performance of CLND were the acral lentiginous melanoma histological subtype, lymph node metastasis size > 1 mm, extracapsular spread, and the participant hospital. Age > 80 years was inversely associated.
Conclusion
While the frequency of CLND in patients with melanoma and positive SLNB has decreased, the indication for systemic adjuvant therapy in these patients has increased. However, CLND is still indicated in patients with high-risk characteristics.
{"title":"Análisis multicéntrico del manejo quirúrgico y tratamiento adyuvante de los pacientes con melanoma y positividad en la biopsia selectiva del ganglio centinela","authors":"E. Samaniego-González , S. Podlipnik , S. Ribero , E. Nagore , A. Boada , J. Cañueto , S. Paradela , B. de Unamuno , P. Rodríguez-Jiménez , S. Puig , J. Malvehy , C. Carrera , G. Roccuzzo , C. Requena , E. Manrique-Silva , N. Richarz , A. Ruiz-Villanueva , V. Traves , S. España-Fernández , R. Botella-Estrada , A. Tejera-Vaquerizo","doi":"10.1016/j.ad.2024.07.017","DOIUrl":"10.1016/j.ad.2024.07.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Complete lymph node dissection (CLND) was the standard practice for patients with melanoma and a positive sentinel lymph node biopsy (SLNB) until the results of 2 clinical trials published in 2016 and 2017 demonstrated that it did not improve melanoma-specific survival (MSS). However, it continues to be performed in some scenarios. No studies have ever been published on lymph node management after a positive SLNB in the routine clinical practice in our setting.</div></div><div><h3>Objectives</h3><div>To determine the evolution of the indication for CLND in patients with a positive SLNB, as well as the characteristics associated with its performance.</div></div><div><h3>Material and methods</h3><div>We conducted a multicenter retrospective observational study with patients with skin melanoma and positive sentinel lymph nodes diagnosed from 2017 through 2022 at 8 Spanish centers and 1 Italian center.</div></div><div><h3>Results</h3><div>A total of 430 patients were included, 54% men, with 358 (75.1%) aged between 45 and 80 years. A total of 133 cases (31%) exhibited Breslow thickness > 4<!--> <!-->mm, 206 cases (49.1%) were ulcerated, and in 213 cases (55.7%), lymph node metastasis was > 1<!--> <!-->mm. Isolated lymphadenectomy or followed by adjuvant therapy was performed in 146 patients (34.1%). After multivariate logistic regression, the factors associated with the performance of CLND were the acral lentiginous melanoma histological subtype, lymph node metastasis size > 1<!--> <!-->mm, extracapsular spread, and the participant hospital. Age > 80 years was inversely associated.</div></div><div><h3>Conclusion</h3><div>While the frequency of CLND in patients with melanoma and positive SLNB has decreased, the indication for systemic adjuvant therapy in these patients has increased. However, CLND is still indicated in patients with high-risk characteristics.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 3","pages":"Pages 233-244"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.ad.2024.07.022
M.G. Baião Catorze , P.M. Leal Filipe
{"title":"Mohs Surgery: From Past to Present, Current State of the Art and Future Perspectives","authors":"M.G. Baião Catorze , P.M. Leal Filipe","doi":"10.1016/j.ad.2024.07.022","DOIUrl":"10.1016/j.ad.2024.07.022","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 3","pages":"Pages 207-209"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.ad.2024.12.015
A. Vicente , A. Pérez-Ferriols , A. Batalla , L. García-Fernandez , B. Pérez , N. Eiris , R. de Lucas , P. De La Cueva , J.M. Carrascosa
Justification and objectives
The Spanish Academy of Dermatology and Venereology (AEDV) Psoriasis and Pediatric Working Groups (PSW and PWG) have developed a set of recommendations for the management of pediatric psoriasis based on the best available evidence and experts’ opinion.
Methodology
The methodology of nominal groups was followed, with help from a scoping review. A coordinator was designated, and a group of experts was selected based on their experience and knowledge on the management of psoriasis. The coordinator defined both the objectives and the key points of the document. Then, with help from a documentalist, a systematic literature review was conducted across Medline, Embase and Cochrane Library until May 2023. Systematic literature reviews, meta-analyses, and observational studies were included. National and international clinical practice guidelines and consensus documents were reviewed. With this information, the coordinator proposed preliminary recommendations that were discussed and modified in a nominal group meeting with all experts. After several review processes, which included an external review, the final document was generated.
Results
Practical recommendations on the evaluation and management of patients with pediatric psoriasis are presented in association with other AEDV documents. The evaluation of the pediatric patient, the definition of the therapeutic objectives, the criteria for indication and selection of treatment are addressed. Practical issues such as therapeutic failure, response maintenance, comorbidity and risk management are also included.
{"title":"[Translated article] Consensus Statement From the Spanish Academy of Dermatology and Venereology (AEDV) Psoriasis Working Group (SWG) and Pediatric Working Group (PWG) on the Management of Pediatric Psoriasis","authors":"A. Vicente , A. Pérez-Ferriols , A. Batalla , L. García-Fernandez , B. Pérez , N. Eiris , R. de Lucas , P. De La Cueva , J.M. Carrascosa","doi":"10.1016/j.ad.2024.12.015","DOIUrl":"10.1016/j.ad.2024.12.015","url":null,"abstract":"<div><h3>Justification and objectives</h3><div>The Spanish Academy of Dermatology and Venereology (AEDV) Psoriasis and Pediatric Working Groups (PSW and PWG) have developed a set of recommendations for the management of pediatric psoriasis based on the best available evidence and experts’ opinion.</div></div><div><h3>Methodology</h3><div>The methodology of nominal groups was followed, with help from a scoping review. A coordinator was designated, and a group of experts was selected based on their experience and knowledge on the management of psoriasis. The coordinator defined both the objectives and the key points of the document. Then, with help from a documentalist, a systematic literature review was conducted across Medline, Embase and Cochrane Library until May 2023. Systematic literature reviews, meta-analyses, and observational studies were included. National and international clinical practice guidelines and consensus documents were reviewed. With this information, the coordinator proposed preliminary recommendations that were discussed and modified in a nominal group meeting with all experts. After several review processes, which included an external review, the final document was generated.</div></div><div><h3>Results</h3><div>Practical recommendations on the evaluation and management of patients with pediatric psoriasis are presented in association with other AEDV documents. The evaluation of the pediatric patient, the definition of the therapeutic objectives, the criteria for indication and selection of treatment are addressed. Practical issues such as therapeutic failure, response maintenance, comorbidity and risk management are also included.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 3","pages":"Pages T254-T280"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.ad.2024.12.010
R. García Castro, C. Manzanas Yustas, L. Núñez Hipólito, I. Alcaraz León
{"title":"[Translated article] Use of Micrografts for Postsurgical Wound Reconstruction: A 21-Case Series","authors":"R. García Castro, C. Manzanas Yustas, L. Núñez Hipólito, I. Alcaraz León","doi":"10.1016/j.ad.2024.12.010","DOIUrl":"10.1016/j.ad.2024.12.010","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 3","pages":"Pages T313-T315"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.ad.2023.08.017
A. Soto-Moreno , P. Díaz-Calvillo , S. Arias-Santiago
{"title":"Síndrome de Kounis, mastocitos más allá de la piel","authors":"A. Soto-Moreno , P. Díaz-Calvillo , S. Arias-Santiago","doi":"10.1016/j.ad.2023.08.017","DOIUrl":"10.1016/j.ad.2023.08.017","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 3","pages":"Pages 305-306"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.ad.2024.06.006
S. Machan , M. Rodríguez , R. Manso , J. Borregón , C. Chamizo , R. Alonso-Alonso , J.L. Rodríguez-Peralto , M.Á. Torres Nieto , C. Monteagudo , E. García Toro , L. Cerroni , C. García , T. Estrach , A. García Herrera , B. Ferrer , V. García-Patos , N. Segues , F.J. Díaz de la Pinta , J.L. Afonso-Martin , Y. Peñate , S.M. Rodríguez-Pinilla
Background
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic T-cell lymphoma with indolent behavior, mostly present in women and associated with immunological diseases whose pathogenic background is still poorly understood. SPTCL is associated with lupus erythematosus panniculitis (LEP) and histologically misdiagnosed.
Objectives
The aim of our study was to identify mutations affecting the pathogenesis of both SPTCL and LEP.
Materials and methods
We studied a total of 10 SPTCL and 10 LEP patients using targeted next-generation sequencing and pyrosequencing. Differences in gene expression between molecular subgroups were investigated using NanoString technology. Clinical data were collected, and correlations sought with the molecular data obtained.
Results
The mutational profile of SPTCL and LEP is different. We identified fewer pathogenic mutations than previously reported in SPTCL, noting a single HAVCR2-mutated SPTCL case. Interestingly, 40% of our SPTCL cases showed the pathogenic TP53 (p.Pro72Arg) (P72R) variant. Although cases showing HAVCR2 mutations or the TP53 (P72R) variant had more severe symptomatic disease, none developed hemophagocytic syndrome (HPS). Furthermore, TP53 (P72R)-positive cases were characterized by a lower metabolic signaling pathway and higher levels of CD28 expression and Treg signaling genes. In addition, 30% of our cases featured the same mutation (T735C) of the epigenetic modificatory gene DNMT3A. None of the LEP cases showed mutations in any of the studied genes.
Conclusions
The mutational landscape of SPTCL is broader than previously anticipated. We describe, for the first time, the involvement of the TP53 (P72R) pathogenic variant in this subgroup of tumors, consider the possible role of different genetic backgrounds in the development of SPTCL, and conclude that LEP does not follow the same pathogenic pathway as SPTCL.
{"title":"Different Mutational Profiles of Subcutaneous Panniculitis-like T-cell Lymphoma and Lupus Panniculitis: An Additional Case Series","authors":"S. Machan , M. Rodríguez , R. Manso , J. Borregón , C. Chamizo , R. Alonso-Alonso , J.L. Rodríguez-Peralto , M.Á. Torres Nieto , C. Monteagudo , E. García Toro , L. Cerroni , C. García , T. Estrach , A. García Herrera , B. Ferrer , V. García-Patos , N. Segues , F.J. Díaz de la Pinta , J.L. Afonso-Martin , Y. Peñate , S.M. Rodríguez-Pinilla","doi":"10.1016/j.ad.2024.06.006","DOIUrl":"10.1016/j.ad.2024.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic T-cell lymphoma with indolent behavior, mostly present in women and associated with immunological diseases whose pathogenic background is still poorly understood. SPTCL is associated with lupus erythematosus panniculitis (LEP) and histologically misdiagnosed.</div></div><div><h3>Objectives</h3><div>The aim of our study was to identify mutations affecting the pathogenesis of both SPTCL and LEP.</div></div><div><h3>Materials and methods</h3><div>We studied a total of 10 SPTCL and 10 LEP patients using targeted next-generation sequencing and pyrosequencing. Differences in gene expression between molecular subgroups were investigated using NanoString technology. Clinical data were collected, and correlations sought with the molecular data obtained.</div></div><div><h3>Results</h3><div>The mutational profile of SPTCL and LEP is different. We identified fewer pathogenic mutations than previously reported in SPTCL, noting a single HAVCR2-mutated SPTCL case. Interestingly, 40% of our SPTCL cases showed the pathogenic <em>TP53</em> (p.Pro72Arg) (P72R) variant. Although cases showing <em>HAVCR2</em> mutations or the <em>TP53</em> (P72R) variant had more severe symptomatic disease, none developed hemophagocytic syndrome (HPS). Furthermore, <em>TP53</em> (P72R)-positive cases were characterized by a lower metabolic signaling pathway and higher levels of CD28 expression and <em>Treg</em> signaling genes. In addition, 30% of our cases featured the same mutation (T735C) of the epigenetic modificatory gene <em>DNMT3A</em>. None of the LEP cases showed mutations in any of the studied genes.</div></div><div><h3>Conclusions</h3><div>The mutational landscape of SPTCL is broader than previously anticipated. We describe, for the first time, the involvement of the <em>TP53</em> (P72R) pathogenic variant in this subgroup of tumors, consider the possible role of different genetic backgrounds in the development of SPTCL, and conclude that LEP does not follow the same pathogenic pathway as SPTCL.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 3","pages":"Pages 210-217"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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