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Chemsex y lesiones cutáneas tras la inyección de mefedrona. A propósito de 3 casos 化学性行为和注射甲氧麻黄酮后的皮肤损伤:3 份病例报告。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2023.08.022
N.M. Román Mendoza , R. Muñoz Martínez , I. Gonzalo González , F.J. Vicente Martín
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引用次数: 0
[Artículo traducido] Eritema elevatum diutinum 二重红斑
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2024.11.005
M. Mansilla-Polo , R. Botella-Estrada
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引用次数: 0
[Translated article] Wood's Light in Inflammatory and Autoimmune Dermatoses, Infections and Skin Cancer 伍德之光在炎症性皮肤病,自身免疫性疾病,感染和皮肤癌。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2024.12.006
S. Gomez-Martinez , J. Ibaceta Ayala , D. Morgado-Carrasco
Wood's light (WL) is a useful, economical and easy-to-learn diagnostic tool. Despite its advantages, the use of LW among dermatologists is limited. In porokeratosis, the “diamond necklace” sign has been described, corresponding to the white fluorescence of the hyperkeratotic scale. Subclinical morphea lesions are seen as well-defined dark macules. Among the pigmentary disorders, the bluish fluorescence of vitiligo, the increased contrast of epidermal melasma, and the follicular-centered red fluorescence of progressive macular hypomelanosis stand out. Regarding skin infections, erythrasma presents a coral red fluorescence; tinea versicolor, yellow-green fluorescence; Pseudomonas aeuriginosa, green fluorescence; and scabies, blue-white fluorescence in the acarine burrows. In skin cancer, LW has been used to delimit the surgical margins of both lentigo maligna and non-melanoma skin cancer, with variable results.
Wood’s light (WL)是一种实用、经济、易学的诊断工具。尽管有其优点,LW在皮肤科医生中的使用是有限的。在角化过度症中,描述了“钻石项链”标志,对应于角化过度鳞片的白色荧光。亚临床morphea病变可见界限分明的黑色斑点。在色素紊乱中,白癜风的淡蓝色荧光,表皮黄褐斑的对比度增加,进行性黄斑低黑症的滤泡中心红色荧光尤为突出。对于皮肤感染,红斑呈现珊瑚红色荧光;花斑癣,黄绿色荧光;金黄色假单胞菌,绿色荧光;疥疮,在棘齿槽里有蓝白色的荧光。在皮肤癌中,LW已被用于划定黄斑恶性和非黑色素瘤皮肤癌的手术边缘,结果不一。
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引用次数: 0
[Translated article] Hives, Papules, Lymphadenopathies, and Systemic Symptoms in a Middle-aged Woman 中年妇女的痣、丘疹、腺病和全身症状。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2024.12.001
L. García Sirvent, J. Espiñeira Sicre, P. Soro Martínez
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引用次数: 0
Análisis multicéntrico del manejo quirúrgico y tratamiento adyuvante de los pacientes con melanoma y positividad en la biopsia selectiva del ganglio centinela 黑色素瘤前哨淋巴结活检阳性患者的手术治疗和辅助治疗多中心分析。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2024.07.017
E. Samaniego-González , S. Podlipnik , S. Ribero , E. Nagore , A. Boada , J. Cañueto , S. Paradela , B. de Unamuno , P. Rodríguez-Jiménez , S. Puig , J. Malvehy , C. Carrera , G. Roccuzzo , C. Requena , E. Manrique-Silva , N. Richarz , A. Ruiz-Villanueva , V. Traves , S. España-Fernández , R. Botella-Estrada , A. Tejera-Vaquerizo

Introduction

Complete lymph node dissection (CLND) was the standard practice for patients with melanoma and a positive sentinel lymph node biopsy (SLNB) until the results of 2 clinical trials published in 2016 and 2017 demonstrated that it did not improve melanoma-specific survival (MSS). However, it continues to be performed in some scenarios. No studies have ever been published on lymph node management after a positive SLNB in the routine clinical practice in our setting.

Objectives

To determine the evolution of the indication for CLND in patients with a positive SLNB, as well as the characteristics associated with its performance.

Material and methods

We conducted a multicenter retrospective observational study with patients with skin melanoma and positive sentinel lymph nodes diagnosed from 2017 through 2022 at 8 Spanish centers and 1 Italian center.

Results

A total of 430 patients were included, 54% men, with 358 (75.1%) aged between 45 and 80 years. A total of 133 cases (31%) exhibited Breslow thickness > 4 mm, 206 cases (49.1%) were ulcerated, and in 213 cases (55.7%), lymph node metastasis was > 1 mm. Isolated lymphadenectomy or followed by adjuvant therapy was performed in 146 patients (34.1%). After multivariate logistic regression, the factors associated with the performance of CLND were the acral lentiginous melanoma histological subtype, lymph node metastasis size > 1 mm, extracapsular spread, and the participant hospital. Age > 80 years was inversely associated.

Conclusion

While the frequency of CLND in patients with melanoma and positive SLNB has decreased, the indication for systemic adjuvant therapy in these patients has increased. However, CLND is still indicated in patients with high-risk characteristics.
导言:完全淋巴结清扫(CLND)是黑色素瘤患者和前哨淋巴结活检(SLNB)阳性患者的标准做法,直到2016年和2017年发表的两项临床试验结果表明,完全淋巴结清扫并不能提高黑色素瘤患者的特异性生存率(MSS)。不过,在某些情况下仍会继续进行。在我们的常规临床实践中,从未发表过关于SLNB阳性后淋巴结管理的研究:目的:确定 SLNB 阳性患者 CLND 适应症的演变情况,以及与执行 CLND 相关的特征:我们开展了一项多中心回顾性观察研究,研究对象为2017年至2022年期间在8个西班牙中心和1个意大利中心确诊的皮肤黑色素瘤和前哨淋巴结阳性患者:共纳入430例患者,54%为男性,其中358例(75.1%)年龄在45岁至80岁之间。133例(31%)患者的布瑞斯洛厚度大于4毫米,206例(49.1%)患者出现溃疡,213例(55.7%)患者的淋巴结转移大于1毫米。146例患者(34.1%)接受了孤立淋巴结切除术或辅助治疗。经过多变量逻辑回归,与实施CLND相关的因素包括尖状皮样黑色素瘤组织学亚型、淋巴结转移灶大小> 1毫米、囊外扩散和参与医院。结论虽然黑色素瘤和 SLNB 阳性患者的 CLND 频率有所下降,但这些患者的全身辅助治疗指征却有所增加。然而,CLND 仍适用于具有高风险特征的患者。
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引用次数: 0
Mohs Surgery: From Past to Present, Current State of the Art and Future Perspectives 莫氏手术:从过去到现在、技术现状和未来展望。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2024.07.022
M.G. Baião Catorze , P.M. Leal Filipe
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引用次数: 0
[Translated article] Consensus Statement From the Spanish Academy of Dermatology and Venereology (AEDV) Psoriasis Working Group (SWG) and Pediatric Working Group (PWG) on the Management of Pediatric Psoriasis 西班牙银屑病小组(GPS)和西班牙皮肤病学和性病学会(AEDV)的西班牙儿科皮肤病学小组(GEDP)关于儿科银屑病管理的共识文件。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2024.12.015
A. Vicente , A. Pérez-Ferriols , A. Batalla , L. García-Fernandez , B. Pérez , N. Eiris , R. de Lucas , P. De La Cueva , J.M. Carrascosa

Justification and objectives

The Spanish Academy of Dermatology and Venereology (AEDV) Psoriasis and Pediatric Working Groups (PSW and PWG) have developed a set of recommendations for the management of pediatric psoriasis based on the best available evidence and experts’ opinion.

Methodology

The methodology of nominal groups was followed, with help from a scoping review. A coordinator was designated, and a group of experts was selected based on their experience and knowledge on the management of psoriasis. The coordinator defined both the objectives and the key points of the document. Then, with help from a documentalist, a systematic literature review was conducted across Medline, Embase and Cochrane Library until May 2023. Systematic literature reviews, meta-analyses, and observational studies were included. National and international clinical practice guidelines and consensus documents were reviewed. With this information, the coordinator proposed preliminary recommendations that were discussed and modified in a nominal group meeting with all experts. After several review processes, which included an external review, the final document was generated.

Results

Practical recommendations on the evaluation and management of patients with pediatric psoriasis are presented in association with other AEDV documents. The evaluation of the pediatric patient, the definition of the therapeutic objectives, the criteria for indication and selection of treatment are addressed. Practical issues such as therapeutic failure, response maintenance, comorbidity and risk management are also included.
理由和目标:西班牙皮肤病和性病学会(AEDV)牛皮癣和儿科工作组(PSW和PWG)根据现有的最佳证据和专家意见,制定了一套治疗小儿牛皮癣的建议。方法:在范围审查的帮助下,遵循了名义群体的方法。指定了一名协调员,并根据他们在牛皮癣管理方面的经验和知识选择了一组专家。协调员定义了文件的目标和要点。然后,在一位文献学家的帮助下,对Medline、Embase和Cochrane图书馆进行了系统的文献综述,直到2023年5月。包括系统文献综述、荟萃分析和观察性研究。审查了国家和国际临床实践指南和共识文件。根据这些资料,协调员提出了初步建议,并在与所有专家举行的名义小组会议上进行了讨论和修改。经过几个评审过程(包括外部评审),最终的文档生成了。结果:对儿童牛皮癣患者的评估和管理提出了实用的建议,并与其他AEDV文件相关联。小儿患者的评估,治疗目标的定义,指征和治疗选择的标准是解决。实际问题,如治疗失败,反应维持,合并症和风险管理也包括在内。
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引用次数: 0
[Translated article] Use of Micrografts for Postsurgical Wound Reconstruction: A 21-Case Series 在21例手术伤口中使用微移植进行重建。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2024.12.010
R. García Castro, C. Manzanas Yustas, L. Núñez Hipólito, I. Alcaraz León
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引用次数: 0
Síndrome de Kounis, mastocitos más allá de la piel 库尼斯综合征,肥大细胞超出皮肤。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2023.08.017
A. Soto-Moreno , P. Díaz-Calvillo , S. Arias-Santiago
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引用次数: 0
Different Mutational Profiles of Subcutaneous Panniculitis-like T-cell Lymphoma and Lupus Panniculitis: An Additional Case Series 皮下泛发性T细胞淋巴瘤和狼疮泛发性T细胞淋巴瘤的不同突变特征:新增病例系列。
IF 3.8 Q1 DERMATOLOGY Pub Date : 2025-03-01 DOI: 10.1016/j.ad.2024.06.006
S. Machan , M. Rodríguez , R. Manso , J. Borregón , C. Chamizo , R. Alonso-Alonso , J.L. Rodríguez-Peralto , M.Á. Torres Nieto , C. Monteagudo , E. García Toro , L. Cerroni , C. García , T. Estrach , A. García Herrera , B. Ferrer , V. García-Patos , N. Segues , F.J. Díaz de la Pinta , J.L. Afonso-Martin , Y. Peñate , S.M. Rodríguez-Pinilla

Background

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic T-cell lymphoma with indolent behavior, mostly present in women and associated with immunological diseases whose pathogenic background is still poorly understood. SPTCL is associated with lupus erythematosus panniculitis (LEP) and histologically misdiagnosed.

Objectives

The aim of our study was to identify mutations affecting the pathogenesis of both SPTCL and LEP.

Materials and methods

We studied a total of 10 SPTCL and 10 LEP patients using targeted next-generation sequencing and pyrosequencing. Differences in gene expression between molecular subgroups were investigated using NanoString technology. Clinical data were collected, and correlations sought with the molecular data obtained.

Results

The mutational profile of SPTCL and LEP is different. We identified fewer pathogenic mutations than previously reported in SPTCL, noting a single HAVCR2-mutated SPTCL case. Interestingly, 40% of our SPTCL cases showed the pathogenic TP53 (p.Pro72Arg) (P72R) variant. Although cases showing HAVCR2 mutations or the TP53 (P72R) variant had more severe symptomatic disease, none developed hemophagocytic syndrome (HPS). Furthermore, TP53 (P72R)-positive cases were characterized by a lower metabolic signaling pathway and higher levels of CD28 expression and Treg signaling genes. In addition, 30% of our cases featured the same mutation (T735C) of the epigenetic modificatory gene DNMT3A. None of the LEP cases showed mutations in any of the studied genes.

Conclusions

The mutational landscape of SPTCL is broader than previously anticipated. We describe, for the first time, the involvement of the TP53 (P72R) pathogenic variant in this subgroup of tumors, consider the possible role of different genetic backgrounds in the development of SPTCL, and conclude that LEP does not follow the same pathogenic pathway as SPTCL.
背景和目的:皮下泛发性类T细胞淋巴瘤(SPTCL)是一种罕见的细胞毒性T细胞淋巴瘤,表现为懒散性,多见于女性,与免疫学疾病相关,其致病背景仍不甚明了。SPTCL与红斑狼疮泛发性淋巴结炎(LEP)相关,在组织学上被误诊。目的:我们的研究旨在确定影响SPTCL和LEP发病机制的基因突变。材料与方法:我们使用靶向新一代测序技术和热释光测序技术共研究了10例SPTCL和10例LEP患者。使用 NanoString 技术研究了分子亚群之间基因表达的差异。结果:SPTCL 和 LEP 的基因突变情况不同。我们在SPTCL中发现的致病突变少于之前的报道,只发现一例HAVCR2突变的SPTCL病例。有趣的是,40%的SPTCL病例出现了致病性TP53(p.Pro72Arg)(P72R)变异。虽然出现HAVCR2突变或TP53(P72R)变异的病例症状更为严重,但没有一例出现嗜血细胞综合征(HPS)。此外,TP53(P72R)阳性病例的特点是代谢信号通路较低,CD28表达和Treg信号基因水平较高。此外,30%的病例具有相同的表观遗传修饰基因 DNMT3A 突变(T735C)。结论:SPTCL的基因突变情况比以前预期的要广泛。我们首次描述了 TP53(P72R)致病变异参与该亚组肿瘤的情况,考虑了不同遗传背景在 SPTCL 发病过程中可能扮演的角色,并得出结论认为 LEP 与 SPTCL 的发病途径并不相同。
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Actas dermo-sifiliograficas
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