Pub Date : 2024-11-12DOI: 10.1016/j.ad.2024.09.018
S García-González, L Prieto-Torres, M García-García
Epstein Barr virus (EBV) positive B lymphoproliferative disorders (LPD) with cutaneous involvement include a series of rare entities that go from indolent processes to aggressive lymphomas. Since the latest WHO-EORTC classification of cutaneous lymphomas in 2018, significant changes have been included in the new classifications of hematological malignancies. B-cell EBV+ LPD mainly affect immunocompromised patients while T-cell EBV+ LPD are more prevalent in specific geographic regions such as Asia, Central America, and South America. This systematic review summarizes the main clinical, histological, immunophenotypic and molecular characteristics of B- and T-cell EBV+ LPD that may compromise the skin at diagnosis. B-cell EBV+ LPD include primary cutaneous lymphomas such as EBV-MCU, as well as cutaneous systemic lymphomas that may present such as lymphomatoid granulomatosis (LG), EBV+ diffuse large B cell lymphoma, NOS, plasmablastic lymphoma (PBL), and extracavitary primary effusion lymphoma (EC-PEL). EBV+, EBV-positive polymorphic B cell LPD, or post-transplant lymphoproliferative disorders (PTLD). Regarding T-cell EBV+ LPD, most of these entities are categorized within T/NK-cell lymphoproliferative processes and lymphomas of childhood, including extranodal T/NK lymphoma, and even more exceptional forms such as EBV-positive T-cell centrofollicular lymphoma and intravascular T/NK-cell lymphoma. Diagnosis is based on integrating the clinical, histological, immunohistochemical, and genetic criteria discussed throughout this article. Management is multidisciplinary, posing a challenge for dermatologists and hematologists involved in the management of these patients. Having scientific evidence available in this field is of paramount importance because overtreatment must be carefully avoided.
皮肤受累的爱泼斯坦-巴氏病毒（EBV）阳性B淋巴增生性疾病（LPD）包括一系列罕见的实体，从不育过程到侵袭性淋巴瘤。自2018年WHO-EORTC对皮肤淋巴瘤进行最新分类以来，血液恶性肿瘤的新分类已发生了重大变化。B 细胞 EBV+ LPD 主要影响免疫力低下的患者，而 T 细胞 EBV+ LPD 在亚洲、中美洲和南美洲等特定地理区域更为流行。本系统综述总结了B细胞和T细胞EBV+ LPD的主要临床、组织学、免疫表型和分子特征，这些特征可能会在诊断时损害皮肤。B 细胞 EBV+ LPD 包括 EBV-MCU 等原发性皮肤淋巴瘤，以及可能出现的皮肤系统淋巴瘤，如淋巴瘤样肉芽肿病（LG）、EBV+ 弥漫性大 B 细胞淋巴瘤、NOS、浆液性淋巴瘤（PBL）和腔外原发性渗出淋巴瘤（EC-PEL）。EBV+、EBV 阳性多形性 B 细胞 LPD 或移植后淋巴组织增生性疾病（PTLD）。关于T细胞EBV+淋巴细胞增生性疾病，这些实体大多归类于T/NK细胞淋巴细胞增生过程和儿童淋巴瘤，包括结节外T/NK淋巴瘤，甚至更特殊的形式，如EBV阳性T细胞中心滤泡淋巴瘤和血管内T/NK细胞淋巴瘤。诊断需要综合本文讨论的临床、组织学、免疫组化和遗传学标准。治疗是多学科的，这给参与这些患者治疗的皮肤科和血液科医生带来了挑战。掌握这一领域的科学证据至关重要，因为必须谨慎避免过度治疗。
{"title":"An update on EBV-related cutaneous lymphoproliferative disorders: a systematic review.","authors":"S García-González, L Prieto-Torres, M García-García","doi":"10.1016/j.ad.2024.09.018","DOIUrl":"https://doi.org/10.1016/j.ad.2024.09.018","url":null,"abstract":"<p><p>Epstein Barr virus (EBV) positive B lymphoproliferative disorders (LPD) with cutaneous involvement include a series of rare entities that go from indolent processes to aggressive lymphomas. Since the latest WHO-EORTC classification of cutaneous lymphomas in 2018, significant changes have been included in the new classifications of hematological malignancies. B-cell EBV+ LPD mainly affect immunocompromised patients while T-cell EBV+ LPD are more prevalent in specific geographic regions such as Asia, Central America, and South America. This systematic review summarizes the main clinical, histological, immunophenotypic and molecular characteristics of B- and T-cell EBV+ LPD that may compromise the skin at diagnosis. B-cell EBV+ LPD include primary cutaneous lymphomas such as EBV-MCU, as well as cutaneous systemic lymphomas that may present such as lymphomatoid granulomatosis (LG), EBV+ diffuse large B cell lymphoma, NOS, plasmablastic lymphoma (PBL), and extracavitary primary effusion lymphoma (EC-PEL). EBV+, EBV-positive polymorphic B cell LPD, or post-transplant lymphoproliferative disorders (PTLD). Regarding T-cell EBV+ LPD, most of these entities are categorized within T/NK-cell lymphoproliferative processes and lymphomas of childhood, including extranodal T/NK lymphoma, and even more exceptional forms such as EBV-positive T-cell centrofollicular lymphoma and intravascular T/NK-cell lymphoma. Diagnosis is based on integrating the clinical, histological, immunohistochemical, and genetic criteria discussed throughout this article. Management is multidisciplinary, posing a challenge for dermatologists and hematologists involved in the management of these patients. Having scientific evidence available in this field is of paramount importance because overtreatment must be carefully avoided.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2024.08.010
F J Melgosa-Ramos, A Vicente Villa, I Betlloch Mas, S Santos-Alarcón
{"title":"MID-TERM SAFETY AND EFFICACY OF UPADACITINIB IN ADOLESCENTS WITH MODERATE-TO-SEVERE ATOPIC DERMATITIS: A REAL-LIFE 34-PATIENT MULTICENTER TRIAL.","authors":"F J Melgosa-Ramos, A Vicente Villa, I Betlloch Mas, S Santos-Alarcón","doi":"10.1016/j.ad.2024.08.010","DOIUrl":"10.1016/j.ad.2024.08.010","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2023.09.033
A Giacaman, L J Del Pozo Hernando, C Calvo Martínez, C Saus-Sarrias
{"title":"New trichoscopic findings in the loose anagen hair syndrome setting.","authors":"A Giacaman, L J Del Pozo Hernando, C Calvo Martínez, C Saus-Sarrias","doi":"10.1016/j.ad.2023.09.033","DOIUrl":"https://doi.org/10.1016/j.ad.2023.09.033","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2023.08.023
M D Pegalajar-García, A Sevilla-Linares, Á Santos Britz-Terrón
{"title":"\"Butterfly\" or malar rash: not everything is lupus.","authors":"M D Pegalajar-García, A Sevilla-Linares, Á Santos Britz-Terrón","doi":"10.1016/j.ad.2023.08.023","DOIUrl":"10.1016/j.ad.2023.08.023","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2024.05.028
C Correia, M Pinho, S Fernandes
{"title":"Slow-growing tumor on the right iliac region of an 11-year-old girl.","authors":"C Correia, M Pinho, S Fernandes","doi":"10.1016/j.ad.2024.05.028","DOIUrl":"https://doi.org/10.1016/j.ad.2024.05.028","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.ad.2023.12.008
O Al-Wattar-Ceballos, L Martínez-Montalvo, M Montero-García
{"title":"RF - An update on the pharmacologic management of androgenetic alopecia in transgender patients.","authors":"O Al-Wattar-Ceballos, L Martínez-Montalvo, M Montero-García","doi":"10.1016/j.ad.2023.12.008","DOIUrl":"https://doi.org/10.1016/j.ad.2023.12.008","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-09DOI: 10.1016/j.ad.2024.11.004
M Trinidad Hasbún, R Agüero, C Decombe
{"title":"Invasive Fusariosis With Nasal Septum Involvement: Case Report of a 7-Year-Old Boy.","authors":"M Trinidad Hasbún, R Agüero, C Decombe","doi":"10.1016/j.ad.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.ad.2024.11.004","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-09DOI: 10.1016/j.ad.2024.11.003
M G Baião Catorze, P M Leal Filipe
{"title":"Mohs Surgery: From Past to Present, Current State of the Art and Future Perspectives.","authors":"M G Baião Catorze, P M Leal Filipe","doi":"10.1016/j.ad.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.ad.2024.11.003","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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