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In vitro synergistic activity of lidocaine and miconazole against Candida albicans 利多卡因与咪康唑体外抗白色念珠菌协同作用的研究
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.32413
M. Cunha, T. P. A. Filho, F. A. Cunha, Ana Gesselena da Silva Farias, I. P. Souza, E. A. Menezes
Candida albicans is the main yeast isolated from vulvovaginal candidiasis(VVC) and a major antifungal used to treat VVC is miconazole (MZ), it shows local toxic effects, such as irritation and burns. The lidocaine (LD) is a local anesthetic. The aim of this study was to evaluate the synergistic activity of LD/MZ against 19 strains of C. albicans isolated from vaginal secretion. 78.9% of the strains were susceptible to the combination LD/MZ, demonstrating synergism of drugs. These drugs can be used to produce vaginal creams to treat VVC, especially drug resistant.
白色念珠菌是从外阴阴道念珠菌病(VVC)中分离出来的主要酵母菌,用于治疗VVC的主要抗真菌药物是咪康唑(MZ),它具有局部毒性作用,如刺激和烧伤。利多卡因(LD)是一种局部麻醉剂。本研究的目的是评价LD/MZ对19株阴道分泌物白色念珠菌的增效作用。78.9%的菌株对LD/MZ联合敏感,显示出药物的协同作用。这些药物可以用来生产阴道药膏来治疗VVC,尤其是耐药的VVC。
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引用次数: 1
Damage caused by exposure to propofol during gestation of mice 小鼠妊娠期间暴露于异丙酚造成的损伤
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.34203
L. A. Sensiate, A. Bispo, K. Guarido, Joelle Toni-Ann Venice Freckleton, M. J. S. Salles
Literature shows that surgical procedure could be necessary at any stage of pregnancy and can cause adverse effects on the mother and fetus. One of the most used anesthetics in surgical centers is propofol however; the safety during pregnancy has not been completely established. The objective of this study was to investigate the possible toxic and teratogenic effects on the intrauterine and post-natal development of mice exposed to the dose of 15 mg kg -1 propofol on the caudal vein fifth, tenth and fifteenth day of gestation. A significant reduction in weight gain was observed in female mice who received a 15 mg kg -1 dose of propofol on the fifth gestational day. A higher rate of embryonic loss post implantation and resorption was also observed in this group. In regards to physical development, the anesthetic increased significantly the offspring weight gain, the time in which pinna detachment occurred, and the anogenital distance of pups whose females received propofol on the fifteenth day of gestation. Based on these results, we concluded that administration of propofol in the beginning stages of gestation increases the number of abortions and promotes alterations in the physical development of pups whose mothers were anesthetized in the final stages of gestation.
文献显示,在怀孕的任何阶段,外科手术都是必要的,并可能对母亲和胎儿造成不良影响。然而,手术中心最常用的麻醉剂之一是异丙酚;怀孕期间的安全性尚未完全确定。本研究旨在探讨15 mg kg -1异丙酚在妊娠第5天、第10天和第15天尾静脉暴露对小鼠宫内和产后发育可能产生的毒性和致畸作用。在妊娠第5天接受15 mg kg -1剂量异丙酚的雌性小鼠体重增加明显减少。在植入后胚胎丢失和再吸收率也较高。在生理发育方面,在妊娠第15天服用异丙酚的雌性幼鼠,麻醉显著增加了幼鼠的体重增加、发生耳廓脱离的时间以及肛门生殖器距离。基于这些结果,我们得出结论,在妊娠初期施用异丙酚会增加流产的数量,并促进在妊娠后期被麻醉的母鼠幼鼠身体发育的改变。
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引用次数: 0
Incidence of urinary infection among kidney-transplant recipients 肾移植受者尿路感染的发生率
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.32766
Alan Cristyan Ramalho, A. P. C. Matta
Urinary tract infection is the most common bacterial complication in renal transplant. This study investigated the number of urinary infection in renal transplant patients at a transplant center aimed at improving nursing care in order to minimize the incidence of urinary infection. We analyzed 59 medical records of patients subjected to renal transplant from May to June 2015 at a transplant center in a hospital in northwestern state of Parana. The prevailing age of the patients was between 50 and 60 years (29%), and the hemodialysis time was up to 24 months (30%). In patients diagnosed with urinary tract infection (36%), the prevalent microorganisms were: Enterobacter cloacae (25%), occurring more frequently in the first month after transplantation (67%). It was concluded the nursing team may to act in the control and prevention of urinary tract infection.
尿路感染是肾移植术后最常见的细菌并发症。本研究对某移植中心肾移植患者泌尿系感染的发生率进行调查,旨在提高护理水平,降低泌尿系感染的发生率。我们分析了2015年5月至6月在西北部巴拉那州一家医院的移植中心接受肾移植的59例患者的医疗记录。患者的主要年龄在50 ~ 60岁之间(29%),血液透析时间长达24个月(30%)。在诊断为尿路感染的患者中(36%),流行的微生物是:阴沟肠杆菌(25%),在移植后的第一个月更常见(67%)。结论护理团队应积极参与尿路感染的控制和预防。
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引用次数: 0
Histological and morphological evaluation of condylar cartilage of young rats in response to stimulation of mandibular protrusion 幼年大鼠髁突刺激后髁突软骨的组织学和形态学评价
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.27789
Milena Peixoto Nogueira de Sá, A. L. Ramos, J. Zanoni, F. D. Souza, Daniele Esteves Pepelascov, R. Terada
The aim of this study was to evaluate the histogical and morphological aspects of the condyle in response to mandibular protrusion induced by composite resin occlusal planes. Thirty five-week-old male Wistar rats were selected and randomly divided in two groups. One group received a composite resin type of oclusal plane that induced mandibular protrusion, and the other was the control group, without treatment. Animals were euthanized after experimental time intervals of 7, 21 and 30 days. For histological analysis, thickness of the proliferative, serial and hypertrophic layers was measured, as well as each layer separately. The highest difference in cartilage thickness was observed at day 21, showing a significant increase of the proliferative layer. There were also other histomorphological changes related to occlusal plane interference. Condylar forward repositioning induced by composite occlusal planes influenced the endochondral ossification, increasing the proliferative layer.
本研究的目的是评估髁突在复合树脂咬合平面引起的下颌骨突出的组织学和形态学方面的反应。选取35周龄雄性Wistar大鼠,随机分为两组。一组采用复合树脂型咬合平面诱导下颌前突,另一组为对照组,不做任何治疗。实验时间间隔为7、21、30天,分别对动物实施安乐死。为进行组织学分析,分别测量增生性层、连续性层和肥厚层的厚度。第21天软骨厚度差异最大,增生层明显增加。还有其他与咬合面干扰有关的组织形态学改变。复合咬合平面诱导髁突前移位影响软骨内成骨,增生层增加。
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引用次数: 1
Concepts applied in daily practice in administration of medicines via nasogastric tube by the nursing team 护理团队在日常鼻胃管给药实践中应用的概念
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.32472
Ingra Monique Duarte Lopes, Edson Antonio Alves Silva, Daniela Ferreira Miyata de Oliveira, A. Sanches
The study aimed to assess the current situation of medication administration via nasogastric tube (VNGT) and identify weaknesses in the process. As a tool, the application of questionnaires to the professionals of the nursing service was used. The questionnaire contained questions and each of them, during the correction, was assigned a specific score. The participant could according to the evaluation system get a grade of 0 to 100 points. Among the participants, 66.7% stated that they had already received some guidance on medication administration via the tube, and after correction and assignment of the notes, the averages obtained were: 47.3 points by the nurses; 38.7 points by nursing technicians; 34.5 points for resident nurses; and 37.0 points by the nursing assistants. The findings of the study indicate that there is a difference between the usual practice and the recommended practice in the literature and the professionals knowledge about administration of medication VNGT is still limited. The insertion of the pharmacist in the multidisciplinary team and disseminating knowledge on incompatibilities, interactions and reactions are of great importance for the improvement of this scenario.
本研究旨在评估鼻胃管(VNGT)给药的现状,并找出该过程中的不足之处。采用问卷调查的方法,对护理服务专业人员进行问卷调查。问卷包含问题,在修改过程中,每个问题都被分配了一个特定的分数。根据评估系统,参与者可以获得0到100分的分数。66.7%的受访护士表示曾接受过点滴给药指导,经批改和分配后,护士的平均得分为:47.3分;护理技师38.7分;住院护士34.5分;护理助理得分37.0分。本研究结果表明,文献中常用做法与推荐做法存在差异,专业人员对VNGT用药的认识仍然有限。药剂师加入多学科团队,传播不相容、相互作用和反应方面的知识,对于改善这种情况非常重要。
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引用次数: 0
Expression of bradykinin in human placenta from healthy and preeclamptic women 缓激素在健康和子痫前期妇女胎盘中的表达
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.30844
Jéssica Costa de Oliveira, W. Pereira, P. Bertevello, L. Cordeiro
This study evaluated the expression of bradykinin (BK) in human placenta from healthy and preeclamptic women. This is a non-randomized experimental study, in which we performed histological analysis of placental tissue to observe changes that occur in each kind of placenta as well as immunohistochemical analysis to investigate the expression of bradykinin. We used ‘Paleontological Statistics software package for education and data analysis’ 3.06 and R for the statistical analysis. The Ethics Committee of the University of Rio Grande do Norte State approved this experiment under protocol number 166370, according to the determinations established by Resolutions 466/12 and 441/11.We found differences between the two kinds of placenta concerning the diameter of the vessels and the rate of cytotrophoblastic invasion. Student’s t-test evidenced significant difference (p = 7.6395 x 10 -5 ) indicating greater marking of BK per section in the healthy placenta group. The result of more significant expression of bradykinin in healthy placenta can be used as a starting point for deeper researches aiming to better characterize and quantify this expression.
本研究评估了缓激素(BK)在健康和子痫前期妇女胎盘中的表达。这是一项非随机的实验研究,我们对胎盘组织进行组织学分析,观察各类胎盘的变化,并进行免疫组织化学分析,研究缓激肽的表达。我们使用“古生物统计学教育与数据分析软件包”3.06,使用R语言进行统计分析。北里奥格兰德州立大学伦理委员会根据第466/12和441/11号决议确定的决定,根据第166370号协议批准了这项实验。我们发现两种胎盘在血管直径和细胞滋养细胞侵袭率方面存在差异。学生t检验证明了显著差异(p = 7.6395 x 10 -5),表明健康胎盘组每切片的BK标记更高。缓激肽在健康胎盘中更显著表达的结果可作为深入研究的起点,旨在更好地表征和量化其表达。
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引用次数: 1
Profile of the cardiac repolarization in cervical spinal cord injury subjects performing physical exercise 运动后颈脊髓损伤患者心脏复极的变化
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.33468
R. Magalhães, Edgar William Martins, A. Maior, M. Marocolo
The aim of the study was to compare rest QT interval and QTcorrected intervals of electrocardiogram in trained men with and without cervical spinal cord injury (CSCI) and investigate cardiac electrocardiogram parameters in trained men with CSCI submitted to maximal effort test. Thirty men were separated into three groups: Control without CSCI (CON, 25.3 ± 4.1 yrs, strength training: 3 days week -1 ; aerobic training 1day week -1 ; n = 10), high volume exercise (30.5 ± 4.3 yrs, 3 day week -1 rugby specific exercises, 60min. day -1 ; n = 12) and moderate volume of exercise (33.7 ± 5.9 yrs, 2 days week -1 specific rugby exercises, 60 min. day -1 ; n = 8) with incomplete CSCI (C5-C7 cervical vertrebae) more than 12 months. Electrocardiogram was recorded in rest, during and after effort test. QT interval was significantly reduced (p = 0.001) in the high volume exercise group compared to control. Corrected QT interval showed no difference between moderate vs. high volume exercise group (p > 0.05). No changes were observed in QT, corrected QT, PR and QRS intervals of electrocardiogram between rest and post effort (p > 0.05). Thus, effort test does not change electrocardiogram parameters in CSCI subjects. High volume of week exercise promotes abnormalities in cardiac repolarization compared to a moderate training program.
本研究的目的是比较有和无颈脊髓损伤(CSCI)的训练男性的静息QT间期和QTcorrected心电图间期,并研究接受最大努力试验的CSCI训练男性的心电图参数。30名男性分为三组:无CSCI的对照组(CON, 25.3±4.1年,力量训练:每周3天-1;有氧训练每周1天-1;N = 10),大运动量运动(30.5±4.3年,每周3天-1橄榄球专项运动,60min。第1天;N = 12)和中等运动量(33.7±5.9年,每周2天-1特定橄榄球运动,每天60分钟-1;n = 8)不完全性CSCI (C5-C7颈椎)超过12个月。分别记录静息、用力试验时和用力试验后的心电图。与对照组相比,大运动量运动组QT间期显著缩短(p = 0.001)。校正后QT间期在中度运动组与高量运动组间无差异(p > 0.05)。两组心电图QT间期、校正QT间期、PR间期、QRS间期在休息与努力后无明显变化(p > 0.05)。因此,用力试验并没有改变CSCI受试者的心电图参数。与适度的训练计划相比,每周高强度的运动可促进心脏复极异常。
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引用次数: 0
Nurse training in primary care: educational actions with people living with Diabetes mellitus 初级护理护士培训:对糖尿病患者的教育行动
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.33389
Camila Aparecida Pinheiro Landim Almeida, Jardel Nascimento da Cruz, Débora Rodrigues Fernandes, Lauryanna de Queiroz Silva, Carlos Henrique Ribeiro Lima, E. C. Lago
Educational actionswith people living with chronic conditions, especially Diabetes mellitus , are a challenge and a necessary strategy in Primary Care, in view of the glycemic balance, the prevention of complications and the improvement of the quality of life. This study aimed to analyze nurse training in educational actions developed in Primary Care with people living with Diabetes mellitus . A qualitative research was conducted with 28 nurses of Primary Care, in Teresina, state of Piaui, Brazil. Data were collected from April to June 2015 through interviews and analyzed by the collective subject discourse technique. The construction of the results was based on four sequential questions made in the interviews, from which emerged 15 central ideas: lectures, group orientation, nursing consultation and home care; theoretical knowledge, practical knowledge, technical knowledge and expertise knowledge; few materials and infrastructure in the basic unit, lack of professional teamwork, reduced workload and little awareness of teachers; and promotion of care and and self-care, family support and prevention of complications. In the analysis of the discourses, it was possible to conclude about the need for Permanent Health Education in Primary Care.
从血糖平衡、预防并发症和改善生活质量的角度来看,对慢性病患者,特别是糖尿病患者的教育行动是初级保健的一项挑战和必要策略。本研究旨在分析糖尿病患者初级保健教育行动中护士培训的情况。对巴西皮奥伊州特雷西纳初级保健部门的28名护士进行了定性研究。数据采集时间为2015年4月至6月,采用访谈法,采用集体主体话语法进行分析。结果的构建基于访谈中提出的四个顺序问题,从中产生了15个中心思想:讲座、小组指导、护理咨询和家庭护理;理论知识、实践知识、技术知识和专业知识;基础单元的材料和基础设施匮乏,缺乏专业的团队合作,工作量减少,教师意识淡薄;促进护理和自我保健,家庭支持和预防并发症。通过对这些论述的分析,可以得出结论,认为有必要在初级保健中开展永久性健康教育。
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引用次数: 5
Prevalence of infection in patients with temporary catheter for hemodialysis in a teaching hospital 某教学医院血液透析临时置管患者感染情况分析
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.28853
Palmiane de Rezende Ramim Borges, J. Bedendo
This study aimed to determine the prevalence of infection related to the provisional catheter for hemodialysis in a teaching hospital and evaluate the risk factors associated with these infections.  A cross-sectional study analyzed by descriptive statistics and parametric tests. It was found that out of 129 patients, 48.8 % had catheter-related infection in hemodialysis, 65 % were male, 33.3 % were 60 years old and over, and 88 % of patients were admitted to intensive care unit. The prevalence of infection in this group was high, and the vast majority of diagnoses of infection were empirical. Given this, it is suggested to establish the routine culture of the catheter tip in all cases of suspected catheter infection to improve the quality of patient care, and the relentless pursuit of the causes that trigger the infection process in line with good practice from across the healthcare team.
本研究旨在了解某教学医院血液透析临时导管相关感染的流行情况,并评估与这些感染相关的危险因素。采用描述性统计和参数检验进行横断面研究分析。结果129例患者中,血液透析导管相关感染占48.8%,男性占65%,60岁及以上占33.3%,88%的患者入住重症监护病房。这一群体的感染率很高,绝大多数的感染诊断都是经验性的。因此,建议在所有疑似导管感染的病例中建立导管尖端的常规培养,以提高患者的护理质量,并根据整个医疗团队的良好实践不懈地追求引发感染过程的原因。
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引用次数: 0
Morphometric analysis of three normal facial types in mixed dentition using posteroanterior cephalometric radiographs: preliminary results 后前位头颅x线片对混合牙列三种正常面部类型的形态计量分析:初步结果
Pub Date : 2017-08-22 DOI: 10.4025/ACTASCIHEALTHSCI.V39I2.34139
R. Bigliazzi, Eliana Ayala Walverde, D. Oliveira, André Pinheiro Magalhães Bertoz, Kurt Faltin Júnior
The aim of the present investigation was to evaluate the craniofacial features of subjects with normal occlusion with different vertical patterns in the mixed dentition using morphometric analysis (Thin-Plate Spline analysis - TPS) applied to posteroanterior (PA) films. The sample comprised 39 individuals (18 females and 21 males), all in mixed dentition, aged from 8.4 to 10 years with satisfactory occlusion and balanced profile and with no history of orthodontic or facial orthopedic treatment. The sample was divided into three groups (mesofacial, brachyfacial and dolichofacial) according to the facial types proposed by Ricketts (1989). The average craniofacial configurations of each study group were obtained by orthogonal superimposition of Procrustes, thereby eliminating size differences and allowing only shape differences between groups to be analyzed by viewing the TPS deformation grid. Significant differences were found among the three facial types but were more remarkable between mesofacials and dolichofacials than between mesofacials and brachyfacials. TPS morphometric analysis proved efficient for accurate visualization of transverse and vertical differences among facial types even before pubertal growth spurt. These differences cannot be easily detected by traditional posteroanterior cephalometry.
本研究的目的是利用形态学分析(薄板样条分析- TPS)应用于后前(PA)片,评估正常咬合的受试者在混合牙列中不同垂直模式的颅面特征。样本包括39名患者(18名女性和21名男性),均为混合牙列,年龄8.4至10岁,咬合良好,轮廓平衡,无正畸或面部矫形治疗史。根据Ricketts(1989)提出的面部类型,将样本分为中面、近面和近面三组。通过Procrustes的正交叠加得到各研究组的平均颅面形态,从而消除了尺寸差异,只允许通过查看TPS变形网格来分析组间的形状差异。三种面部类型之间存在显著差异,但中面相和近面相之间的差异比中面相和近面相之间的差异更显著。TPS形态计量学分析证明,即使在青春期生长高峰之前,也能准确地显示面部类型的横向和纵向差异。这些差异不能通过传统的后前位测量术轻易地检测出来。
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引用次数: 1
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