Pub Date : 2026-01-19DOI: 10.1186/s42523-025-00503-y
Anu V Ranade, Grisilda Vidya Bernhardt, Megna Srinivas, Damodara Gowda K M, Firdos Ahmad, Suni Ebby, Asima Karim, Naveed Ahmed Khan, Josemin Jose, Gopika Ramachandran, Hezlin Marzook, Rizwan Qaisar
The human body is adapted to Earth's gravity, but space microgravity significantly alters kidney function, with the hindlimb unloaded (HU) mouse model serving as a valuable tool for studying these effects. During space travel, changes in gut microbiota can lead to health-related issues. In this study, we explored the protective role of crocodile gut microbiome media on kidney health in a HU mouse model, given the known impact of space travel on gut microbiota and related health issues. Male C57BL/6 mice (four months old) were divided into a ground-based control group (GC), HU mice fed with distilled water (HU), and HU mice fed with crocodile bacterial conditioned media (HU-CP). All groups were maintained in a controlled environment for three weeks. At the end of the experiment, mice were euthanized, kidney tissues were dissected for histopathological examination and transcriptomic analysis. Statistical analysis was performed using one-way ANOVA followed by Tukey's multiple comparison test, with p < 0.05 considered significant. Transcriptomic analysis revealed distinct gene expression profiles across GC, HU, and HU-CP groups, with HU-CP inducing both unique (4325 genes) and differential (975 genes) expression compared to HU group. The treatment partially restored glomerular morphology, reduced inflammation, and reversed gene expression alterations associated with oxidative stress, apoptosis, fibrosis, and inflammation. The crocodile bacterial conditioned media demonstrated potential therapeutic benefits in mitigating renal injury induced by simulated microgravity in HU mice. Further research is needed to elucidate the specific mechanisms involved and explore the potential clinical applications of this approach.
{"title":"Gut microbiome- targeted intervention ameliorates structural and transcriptomic changes in the kidney of hindlimb unloaded mouse model.","authors":"Anu V Ranade, Grisilda Vidya Bernhardt, Megna Srinivas, Damodara Gowda K M, Firdos Ahmad, Suni Ebby, Asima Karim, Naveed Ahmed Khan, Josemin Jose, Gopika Ramachandran, Hezlin Marzook, Rizwan Qaisar","doi":"10.1186/s42523-025-00503-y","DOIUrl":"10.1186/s42523-025-00503-y","url":null,"abstract":"<p><p>The human body is adapted to Earth's gravity, but space microgravity significantly alters kidney function, with the hindlimb unloaded (HU) mouse model serving as a valuable tool for studying these effects. During space travel, changes in gut microbiota can lead to health-related issues. In this study, we explored the protective role of crocodile gut microbiome media on kidney health in a HU mouse model, given the known impact of space travel on gut microbiota and related health issues. Male C57BL/6 mice (four months old) were divided into a ground-based control group (GC), HU mice fed with distilled water (HU), and HU mice fed with crocodile bacterial conditioned media (HU-CP). All groups were maintained in a controlled environment for three weeks. At the end of the experiment, mice were euthanized, kidney tissues were dissected for histopathological examination and transcriptomic analysis. Statistical analysis was performed using one-way ANOVA followed by Tukey's multiple comparison test, with p < 0.05 considered significant. Transcriptomic analysis revealed distinct gene expression profiles across GC, HU, and HU-CP groups, with HU-CP inducing both unique (4325 genes) and differential (975 genes) expression compared to HU group. The treatment partially restored glomerular morphology, reduced inflammation, and reversed gene expression alterations associated with oxidative stress, apoptosis, fibrosis, and inflammation. The crocodile bacterial conditioned media demonstrated potential therapeutic benefits in mitigating renal injury induced by simulated microgravity in HU mice. Further research is needed to elucidate the specific mechanisms involved and explore the potential clinical applications of this approach.</p>","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":"8 1","pages":"6"},"PeriodicalIF":4.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1186/s42523-025-00502-z
Li Liu, Herman P Spaink
{"title":"The function of Toll-like receptor 2 in control of transcriptome responses to the microbiome and microbiome composition.","authors":"Li Liu, Herman P Spaink","doi":"10.1186/s42523-025-00502-z","DOIUrl":"10.1186/s42523-025-00502-z","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":"8 1","pages":"5"},"PeriodicalIF":4.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1186/s42523-025-00497-7
Matteo Buffoni, Jesse J Kerkvliet, Henk Enting, Jannigje G Kers, Malbert Rogers, J Arjan G M de Visser, Fernanda L Paganelli, Rob J L Willems, Anita C Schürch
{"title":"Coccidiosis prevention strategies shape the microbiome, resistome and mobilome composition in the broiler gut.","authors":"Matteo Buffoni, Jesse J Kerkvliet, Henk Enting, Jannigje G Kers, Malbert Rogers, J Arjan G M de Visser, Fernanda L Paganelli, Rob J L Willems, Anita C Schürch","doi":"10.1186/s42523-025-00497-7","DOIUrl":"10.1186/s42523-025-00497-7","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":"8 1","pages":"3"},"PeriodicalIF":4.4,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12797969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1186/s42523-025-00513-w
Andrea Becchimanzi, Giovanna De Leva, Alfonso Cacace, Ilaria Di Lelio, Claudia Damiani, Maria Cristina Digilio, Emilio Caprio, Guido Favia, Francesco Pennacchio
{"title":"Deformed Wing Virus infection induces immunosuppression and gut dysbiosis in honey bees.","authors":"Andrea Becchimanzi, Giovanna De Leva, Alfonso Cacace, Ilaria Di Lelio, Claudia Damiani, Maria Cristina Digilio, Emilio Caprio, Guido Favia, Francesco Pennacchio","doi":"10.1186/s42523-025-00513-w","DOIUrl":"10.1186/s42523-025-00513-w","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":"13"},"PeriodicalIF":4.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1186/s42523-025-00509-6
Friscasari F Gurusinga, Sabine Hurka, Daniel Kreft, Till Röthig, Andreas Vilcinskas, Dorothee Tegtmeier
{"title":"Diet chemistry and cross-kingdom microbiota associate with black soldier fly larvae performance on regional side streams.","authors":"Friscasari F Gurusinga, Sabine Hurka, Daniel Kreft, Till Röthig, Andreas Vilcinskas, Dorothee Tegtmeier","doi":"10.1186/s42523-025-00509-6","DOIUrl":"https://doi.org/10.1186/s42523-025-00509-6","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1186/s42523-025-00501-0
Emma T Helm, Eric R Burrough, Nicholas K Gabler, Fernando L Leite
{"title":"Lawsonia intracellularis infection induces changes in microbial community function and composition associated with reduced pig growth and feed efficiency.","authors":"Emma T Helm, Eric R Burrough, Nicholas K Gabler, Fernando L Leite","doi":"10.1186/s42523-025-00501-0","DOIUrl":"10.1186/s42523-025-00501-0","url":null,"abstract":"","PeriodicalId":72201,"journal":{"name":"Animal microbiome","volume":"8 1","pages":"1"},"PeriodicalIF":4.4,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12771854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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