Annals of 3D printed medicine最新文献

3D printing is increasingly used to fabricate medical devices and educational models, yet most studies to-date focus on a particular case study or training scenario. This study instead seeks to understand the relative importance of different qualities for 3D printed anatomical training models, including haptics, accuracy and costs. Clinicians at a major Australian hospital were presented with 24 3D printed prototypes for neurosurgical education in an interactive exhibition. These were produced by undergraduate industrial design students. A post-exhibition survey found that the top quality required in a 3D printed educational model was to feel realistic (33%), followed by accuracy to real anatomy (27%). A separate survey of other health professionals working within health-related disciplines and research also supported these two qualities as most important after attending the exhibition. 60% of clinicians left the exhibition believing that 3D printing plays a moderate or significant role in the hospital/health system, while 100% of other health professionals shared this same opinion. With a range of materials, 3D print and other technologies employed in the production of the models, this unique study helps clarify the core considerations when designing and 3D printing educational models for neurosurgery and other medical disciplines, and highlights some of the differences between clinicians and other health professionals in relation to the technology.

The management of every disease is cumbersome and considered a significant burden, but the treatment of chronic diseases is more arduous than any other disease process. These diseases often demands a long-term pharmacotherapy, drug and treatment monitoring and regular follow-ups. However, the treatment regimen may be hindered as both patient-compliance and medication adherence are imperative factors for optimum therapeutic effect, and any aberrations associated with the latter may beget a change in the dosing, leading to dose-related adverse effects. However, the utilization of 3D printed personalized medicines may be a panacea for these problems, significantly reducing the need for dosing errors, treatment monitoring and regular follow-ups with healthcare providers. This article aims to extrapolate the utility of various additive manufacturing and 3D printed medicines for the management of chronic diseases, recent advancements and observations in the latter, and the impediments that need to be addressed before launching these medicines in the commercial markets.

Over the last thirty years, there has been an increase in the adoption of 3D printing by the medical community to create devices for patients that require custom and rapid solutions. In turn, a demand has been created for a variety of specifically engineered biocompatible materials. The aim of this study was to review the information provided with biocompatible photosensitive resins with regards to their intended uses, cited biocompatibility certifications, and post-processing technique, and arising from this, detail challenges for users when making an informed and safe decision regarding material selection.

A primary level search was performed collecting information from the grey literature available from the websites of manufacturers marketing biocompatible photosensitive resins for 3D printing. Only materials that were stated as biocompatible were included in the study.

The results presented a large range of biocompatible materials with varying intended uses. The majority of materials were specifically for dental applications, followed by general medical use, then specific medical applications. A lack of standardisation was noted with regards to the amount and quality of information that is provided with the materials, therefore, due diligence should be performed by the user when selecting a material for their specific application.

Introduction

3D printing in distal humerus fracture surgery has not been evaluated despite increasing popularity.

Methods

A retrospective study comparing distal humerus fracture surgery pre-operative plans to actual surgical plans and constructs was conducted using radiographs, CTs, 3D CT reconstructions, and 3D printed models.

Results

No difference existed among imaging modalities for approach or plate size. 3D CT reconstructions best predicted lateral plate size. 3D printed models best predicted medial plate size. 3D printed models elicited higher confidence in pre-operative plan.

Discussion

3D printed models were an equivalent tool for pre-operative planning compared to other modalities in our study.

COVID-19 has been spread in more than 220 countries and caused global health concerns. The supply chain disruptions have abruptly affected due to the second wave of COVID-19 in various countries and caused unavailability and shortage of medical devices and personal protective equipment for frontline healthcare workers. Three-dimensional (3D) printing has proven to be a boon and revolutionized technology to supply medical devices and tackle the situation caused by the COVID-19 pandemic. The diverse designs were produced and are currently used in hospitals by patients and frontline healthcare doctors. This review summarises the application of 3D printing during COVID-19. It collects the comprehensive information of recently designed and fabricated protective equipment like nasopharyngeal swabs, valves, face shields, facemasks and many more medical devices. The drawbacks and future challenges of 3D printed medical devices and protective equipment is discussed.

Foot fractures have always been a great concern due to their complex anatomical structure. Medical practitioners face difficulties while operating complex anatomical structures through conventional treatment, and revision surgeries may occur in multi-fractured complex cases. The surgeon requires understanding the complex geometry of the foot. The Three-dimensional (3D) printing technology is rapidly used in the biomedical domain due to its advantages like freedom to design, complex structure fabrication, cost-effectiveness and ease of use. 3D printing is used in the biomedical field for various applications like the fabrication of hydrogels, scaffolds, vascularized soft tissues and bone implants. The role of 3D printing in biomedical is becoming vital in drug formulation, surgical planning, implants prostheses-orthoses, tissue engineering, anatomical model and organ printing. Therefore, this mini-review presents the recent advancement in 3D printing technology for foot and ankle fractures with their advantages like surgical planning, intraoperative directions, customized prostheses and orthoses. This mini-review paper is helpful for medical surgeons, researchers, and design engineers to understand the potential of 3D printing technology and its usage in the biomedical domain.

The COVID-19 pandemic produced unprecedented challenges to healthcare and medical device manufacturing (e.g. personal protective device and replacement part shortages). Additive manufacturing, 3D printing, and the maker community were uniquely positioned to respond to these needs by providing in-house design and manufacturing to meet the needs of clinicians and hospitals. This paper reviews the pandemic response of Children's Hospital of Philadelphia CHAMP 3D Lab, a point-ofcare3D printing team that supports clinical and research projects across the hospital network. The CHAMP team responded to a variety of COVID-19 healthcare needs including providing protective eyewear and ventilator components, creating a transport hook, and designing a novel transparent facemask. This case series details our response to these needs, describing challenges experienced and lessons learned in overcoming them so that others may learn from our experiences. Challenges to responding to the pandemic included the need to handle urgent pandemic related requests in addition to our standard fare. This required us to not only expand our capacity without additional resources, but also to develop a system of prioritization. Specific changes made included: streamlining workflows, identifying safety review processes, and developing/enlisting a network of collaborators. Further, we consider how to transition to a future, post-pandemic world without losing the cohesive drive of emergency-induced innovation. This paper aims to share what we have learned and to encourage both teams currently engaged in the printing community and those looking to join it

The desire to rapidly integrate 3D printing technology by the surgical community, using both commercially available 3D printed custom devices and the emerging trend toward benchtop solutions. Sterilization guidelines for commercially available medical devices, is defined by manufacturers following industrial testing of approved sterilization protocols, whereas benchtop or bedside manufacture of devices by surgical units wishing to adopt and use 3D printed materials represents a grey area where regulation, standards or guidelines do not currently exist. To address this question, we have reviewed the literature. A search of Pubmed for search terms relating to sterilization and 3D printing was subjected to abstract and bibliographic review to identify relevant articles discussing sterilization of 3D printed devices or materials. Only a handful of authors in the peer reviewed literature have addressed the issue of sterilization of 3D printed materials. Commercial “white papers” provide the remainder of available information on the subject. In the quest to adapt and evolve our surgical practice toward the use of “benchtop” 3D-printing, the issue of sterilization was readily identified. The anecdotal experience reported here, with failed attempts using heat dependent sterilization together with evaluation of the literature and review of the available options has directed us toward low-temperature sterilization techniques as standard for sterilization of “in house” 3D printed Models. VHP as a widely institutionally available and employed technology would seem the logical choice as it is readily available, commonly used technique in hospital sterilization departments and quick , simple process compatible with a variety of materials.

PolyJet 3D printing can be used to fabricate colored physical models of anatomical structures such as skull and heart with realistic appearances. These medical models can be used for surgical simulation and planning of complex operations, as well as anatomy teaching. PolyJet is theoretically capable of producing any color by mixing multiple materials. However, the measured color of a sample printed by PolyJet is often different from the specified color in the printer software. Therefore, it is often difficult to predict the measured color of a sample before printing. This paper reports a study on predictive relationships between measured color and four control factors of PolyJet (i.e., three RGB values of specified color and finish type) by design of experiments and application of multilayer perceptron (MLP) neural network model. Experimental data are collected using a full factorial design of experiments. These data are used to train and test the MLP model using 5-fold cross validation. Then, the prediction performances of the MLP model are compared with a linear regression model and a cubic regression model. The results show that the MLP model is capable of predicting measured color with higher accuracy.