Annals of 3D printed medicine最新文献

Reproducibility of radiomics features necessitates that scanner noise be considered prior to feature extraction. Phantom research provides the opportunity for such ‘ground truth’ measurements, without the additional complication of patient-related factors. The aim of this technical note was to create a 3D printed Magnetic Resonance Imaging (MRI)-compatible pelvic phantom that can be used for subsequent analysis of the impact of scanner noise on the reproducibility of radiomics features.

A 3D printed phantom of a male pelvis was created using fused deposition modelling technology. It was 3D printed using the high density MRI-compatible acrylonitrile butadiene styrene (ABS). The ‘negative’ mould created was then filled with silicone, and the prostate gland and femoral heads were also simulated.

We successfully created an MRI-compatible 3D printed pelvic phantom, with a test scan. The phantom will subsequently be utilised to determine the impact of MRI scanner noise on radiomics feature reproducibility.

In this manuscript we assessed the utility of a low-cost 3D printed microscope to evaluate esophageal biopsies. We conducted a comparative analysis between the traditional microscope and our 3-D printed microscope, utilizing a set of esophageal biopsy samples obtained from patients undergoing screening endoscopy. Two pathologists independently examined 30 esophageal biopsies by light microscopy and digital images obtained using a low-cost 3D printed microscope (Observer 1 and 2). The glass slide consensus diagnosis was compared to the findings of 2 additional pathologist who independently just reviewed the digital images (Observer 3 and 4). The intra-observer agreement was substantial to almost perfect for observer 1 (k:0.64) and 2 (k:0.84). All four observers had 100 % sensitivity and negative predictive value, whereas specificity ranged from 59 % to 100 % and positive predictive value ranged from 21 % to 100 %. The PPV and specificity were lower for the two Observers (3 and 4) who just examined the digital images. Overall, our results suggest that telepathology may be used with high sensitivity and specificity, utilizing the pictures produced by our 3D-printed microscope.

Three-dimensional (3D) printing technology is developing as a dominant tool for biomedical engineering by supporting 3D cell culture within compound 3D biomimetic buildings. Biomaterial and Tissue engineering has developed as a favorable alternative method in the treatment of bones, teeth, and organs. This paper summarizes the current research status and attention of the 3D biomaterials scaffolds in bone tissue engineering applications. Several 3D scaffolds fabricated from several types of biodegradable materials have been established. The crucial topics of 3D printing techniques are recognized and deliberated with the future improvement of innovative biomaterials. There has been a prompt development in the applications of 3D printing in engineering customized implants, drug delivery devices, prostheses, and 3D scaffolds for regenerative medicine and tissue engineering. Medical 3D printing technologies are classified into the following categories: Fused Deposition Modeling (FDM), Extrusion-based 3D bioprinting, Selective Laser Sintering (SLS)/Selective Laser melting (SLM), Electron Beam Manufacturing (EBM), Stereolithography (SLA) and Digital Light Processing (DLP) printing techniques, and their clinical applications, different types of biomaterials currently used by researchers, and key limitations are discussed in detail. In Addition, the most advanced and commonly used metals, bioceramics, polymers, and composites in tissue engineering are briefly reviewed as well.

Osteonecrosis of the midfoot is a rare but debilitating pathology that can severely decrease quality of life. Surgical treatment is often complex and can lead to suboptimal outcomes. Additive manufacturing or 3D printing can provide a more patient specific approach to address these difficult entities. This case report highlights the successful use of custom 3D printed implants to replace the navicular and cuboid bones for treatment of osteonecrosis by providing a unique mixture of joint fusion and resurfacing interfaces in a 47-year-old active female. At the final follow up of 30 months, the patient continues to express satisfaction with her procedure and perform physical activities without pain.

The work proposes a perspective on 3D printing in the medical field. The current core applications, which are primarily bioprinting, models in surgery preparation, surgical instruments, prosthetics, drugs, drug delivery systems, streamlined drug development process, and educational medical models, are first reported. The challenges and opportunities of the technology are highlighted, and the present and expected future markets of the technology are considered. The further developments from synergies with artificial intelligence (AI), 4D printing, and the Internet of Things (IoT) is finally examined to provide a comprehensive outlook of where we are, and where we are after, subjected to which constraints.

In this technical note we report a case where 3D-printing aided the reassembly of skull fragments in a homicide with severe tampering of the bones. A young male was shot, the body was incinerated and crushed with garden tools resulting in hundreds of brittle, calcine bone fragments from the skull. An antemortem computed tomography (CT)-scan of the skull was available from a previous assault of the victim. To aid the process of reassembly we used the antemortem CT-data to develop a 3D fixture-grid of the cranial cavity. The 3D grid was utilized as an anatomically correct template for bone reconstruction. This novel technique was based solely on open-source software including 3D Slicer and Blender and could have the potential to aid similar cases.