Biological psychiatry global open science最新文献

英文中文

The Immunologic Underpinnings of Post-Stroke Depression 脑卒中后抑郁的免疫学基础

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-07-28 DOI: 10.1016/j.bpsgos.2025.100575

Nina Vindegaard Sørensen , Anders Hougaard , Christina Kruuse , Michael Eriksen Benros

Post-stroke depression is a common consequence of stroke with an estimated prevalence of approximately 30% in stroke patients. It negatively impacts both rehabilitation and quality of life after stroke. Stroke induces an acute activation of the immune system in the central nervous system with concomitant immunologic alterations in the periphery. Immunologic alterations have been associated with non-stroke-related depression, and the evidence points to both central and peripheral immune activation with bidirectional interactions. By identifying and evaluating the current evidence of immunologic alterations associated with depression, stroke, and post-stroke depression, we outline the current knowledge and hypotheses on stroke-related immunologic alterations and associations with the subsequent risk of post-stroke depression. This includes immune system alterations in the cerebrospinal fluid and blood; pre- and post-stroke infections; the blood-brain barrier; autoimmunity of the central nervous system; brain imaging; the spleen-brain, gut-brain, and neuroendocrine-immune axes; and immunogenetic studies. All these topics are discussed within the context of post-stroke depression, pointing to a potential involvement of a multifactorial immunologic pathophysiology. In this narrative review, we identify key directions for future research and conclude by offering perspectives related to the therapeutic potential and associated challenges of this underinvestigated but important topic in neuropsychiatry.

脑卒中后抑郁是脑卒中的常见后果，估计在脑卒中患者中患病率约为30%。它对中风后的康复和生活质量都有负面影响。中风引起中枢神经系统免疫系统的急性激活，并伴有周围神经系统的免疫改变。免疫改变与非卒中相关性抑郁有关，证据表明中枢和外周免疫激活具有双向相互作用。通过识别和评估与抑郁、卒中和卒中后抑郁相关的免疫改变的现有证据，我们概述了卒中相关免疫改变及其与卒中后抑郁后续风险的关联的现有知识和假设。这包括脑脊液和血液中的免疫系统改变；中风前后感染；血脑屏障；中枢神经系统自身免疫；大脑成像;脾-脑、肠-脑和神经内分泌-免疫轴；免疫遗传学研究。所有这些主题都在卒中后抑郁的背景下进行了讨论，指出了多因素免疫病理生理学的潜在参与。在这篇叙述性综述中，我们确定了未来研究的关键方向，并通过提供与神经精神病学中这一研究不足但重要的主题的治疗潜力和相关挑战相关的观点来总结。

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引用次数: 0

Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses 利用观察性和遗传学分析了解精神疾病、慢性腰痛和脊柱退行性疾病的合并症

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-08-11 DOI: 10.1016/j.bpsgos.2025.100588

Dan Qiu , Eleni Friligkou , Jun He , Brenda Cabrera-Mendoza , Mihaela Aslan , Mihir Gupta , Renato Polimanti

Background

Psychiatric disorders and symptoms are associated with differences in pain perception and sensitivity. These differences can have important implications in treating spinal degenerative disease (SDD) and chronic low back pain (CLBP).

Methods

Leveraging UK Biobank (UKB) (n = 402,072) and All of Us Research Program (AoU) (n = 157,415) data, we investigated the effects linking psychiatric disorders to SDD and CLBP. We applied multinominal regression models, polygenic risk scoring, and one-sample Mendelian randomization (MR) to triangulate the effects underlying the observed associations. We also performed gene ontology and drug-repurposing analyses to dissect the biology shared among mental illnesses, SDD, and CLBP.

Results

When we compared individuals affected only by SDD, those affected only by CLBP, and those affected by both conditions with control participants, observational and genetically informed analyses highlighted that the strongest effects across the 3 case groups were observed for alcohol use disorder, anxiety, depression, and posttraumatic stress disorder. Additionally, schizophrenia and its polygenic risk score appeared to have an inverse relationship with CLBP, SDD, and their comorbidity. One-sample MR highlighted a potential direct effect of internalizing disorders on the outcomes investigated that was particularly strong on SDD. Our drug repurposing analyses identified histone deacetylase inhibitors as targeting molecular pathways shared by psychiatric disorders, SDD, and CLBP.

Conclusions

These findings support that the comorbidity among psychiatric disorders, SDD, and CLBP is due to the contribution of direct effects and shared biology linking these health outcomes. These pleiotropic mechanisms, together with sociocultural factors, play a key role in shaping the SDD-CLBP comorbidity patterns that have been observed across the psychopathology spectrum.

精神疾病和症状与疼痛感知和敏感性的差异有关。这些差异对治疗脊柱退行性疾病（SDD）和慢性腰痛（CLBP）具有重要意义。方法利用UK Biobank （n = 402,072）和All of Us Research Program （n = 157,415）的数据，研究精神障碍与SDD和CLBP之间的关系。我们应用多项回归模型、多基因风险评分和单样本孟德尔随机化（MR）来三角测量观察到的关联的影响。我们还进行了基因本体论和药物再利用分析，以剖析精神疾病、SDD和CLBP之间共有的生物学特征。结果：当我们将仅受SDD影响的个体、仅受CLBP影响的个体以及同时受两种情况影响的个体与对照组进行比较时，观察性和遗传学分析强调，在3个病例组中，酒精使用障碍、焦虑、抑郁和创伤后应激障碍的影响最大。此外，精神分裂症及其多基因风险评分似乎与CLBP、SDD及其合并症呈反比关系。单样本MR强调了内化障碍对所调查结果的潜在直接影响，尤其是对SDD的影响。我们的药物再利用分析确定了组蛋白去乙酰化酶抑制剂靶向精神疾病、SDD和CLBP共有的分子途径。结论：这些发现支持精神疾病、SDD和CLBP之间的共病是由于直接影响和共同的生物学关系导致的。这些多效性机制，连同社会文化因素，在形成在精神病理谱中观察到的SDD-CLBP共病模式中起着关键作用。

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引用次数: 0

Associations Between Head Motion, Age, and Psychiatric Diagnoses in a Large-Scale Developmental Sample 大规模发育样本中头部运动、年龄和精神病诊断之间的关系

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-09-23 DOI: 10.1016/j.bpsgos.2025.100569

Jonathan Power, Conor Liston

引用次数: 0

A Multimodal Observational Case-Control Study Exploring Gut Microbiota–Hippocampus Alterations in Individuals With High Positive Schizotypy From the General Population 一项多模式观察性病例对照研究探讨了普通人群中高阳性分裂型个体的肠道微生物群-海马体改变

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-07-17 DOI: 10.1016/j.bpsgos.2025.100567

Galya C. Iseli , Jorge F. Vázquez-Castellanos , David Coynel , James M. Stone , Mariana Zurita Soler , Paul Allen , Fernando Zelaya , Muriel Derrien , Undine E. Lang , Martin Debbané , Ulrich Ettinger , Jeroen Raes , André Schmidt

Background

The hippocampus plays a critical role in psychosis, with reduced volume observed across the psychosis continuum. These structural changes are associated with cognitive deficits, symptom severity, and increased risk of psychosis progression. Elevated hippocampal perfusion and glutamate/GABA (gamma-aminobutyric acid) imbalance further suggest metabolic dysregulation as a key mechanism. Gut microbiota composition can influence hippocampal metabolism, but their interplay remains to be explored.

Methods

In this cross-sectional study, we recruited 142 healthy participants from the general population, yielding 69 individuals with high schizotypy (HS) and 72 individuals with low schizotypy. All underwent clinical and cognitive testing, multimodal neuroimaging, and gut microbiota analysis via 16S ribosomal RNA gene sequencing. Hippocampal subfield volumes (structural magnetic resonance imaging), perfusion (arterial spin labeling) and glutamate/GABA levels (proton magnetic resonance spectroscopy), and microbial taxa (abundance, diversity, enterotypes) were assessed.

Results

Group comparisons of cognition, multimodal neuroimaging, and gut microbiome composition did not reveal significant differences after correction for multiple comparisons. Within the HS group, glutamate (r = 0.38, p = .003) and GABA (r = −0.36, p = .003) ratios were linked to social withdrawal. Across the entire sample, left hippocampal subfield volumes and glutamate/GABA levels differed significantly between predominant gut microbial enterotypes.

Conclusions

Our results suggest a potential relationship between aberrant gut microbial composition and hippocampal alterations in people with positive schizotypy from the general population. Our findings inform future large-scale research that further explores specific mechanisms of gut microbiome-hippocampus interactions in psychosis and the potential of tailored microbial interventions targeting hippocampal-mediated symptoms.

背景：海马体在精神病中起着关键作用，在精神病连续体中观察到体积减小。这些结构变化与认知缺陷、症状严重程度和精神病进展风险增加有关。海马灌注升高和谷氨酸/GABA （γ -氨基丁酸）失衡进一步表明代谢失调是其关键机制。肠道菌群组成可以影响海马代谢，但它们之间的相互作用仍有待探索。方法在横断面研究中，我们从普通人群中招募了142名健康受试者，其中69名为高分裂型，72名为低分裂型。所有人都进行了临床和认知测试，多模式神经成像，并通过16S核糖体RNA基因测序进行了肠道微生物群分析。评估海马亚场体积（结构磁共振成像）、灌注（动脉自旋标记）和谷氨酸/GABA水平（质子磁共振光谱），以及微生物类群（丰度、多样性、肠型）。结果组间认知、多模态神经影像学和肠道微生物组组成的比较在校正多重比较后无显著差异。在HS组中，谷氨酸（r = 0.38, p = 0.003）和GABA （r = - 0.36, p = 0.003）比值与社交退缩有关。在整个样本中，主要肠道微生物肠型之间的左海马亚区体积和谷氨酸/GABA水平存在显著差异。结论研究结果提示，与一般人群相比，分裂型阳性患者肠道微生物组成异常与海马结构改变之间存在潜在关系。我们的发现为未来的大规模研究提供了信息，这些研究将进一步探索精神病中肠道微生物群-海马体相互作用的特定机制，以及针对海马体介导症状的定制微生物干预的潜力。

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引用次数: 0

The Emerging Role of the DDAH Proteins in Psychiatric Disorders DDAH蛋白在精神疾病中的新作用

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-07-28 DOI: 10.1016/j.bpsgos.2025.100574

Magdalini R. Vareltzoglou , Roman N. Rodionov , Anthony C. Vernon , Nadine Bernhardt

The heterogeneous nature of psychiatric disorders complicates their clinical management and the development of novel treatments, imposing a significant burden on both patients and health care systems. To address these challenges, it is essential to continuously identify new targets involved in their pathogenesis. In this narrative review, we propose the dimethylarginine dimethylaminohydrolase (DDAH) proteins, already known for their significant role in cardiovascular disease, as promising novel treatment targets for psychiatric conditions. The DDAH proteins exist in 2 isoforms, DDAH1 and DDAH2, which both regulate nitric oxide homeostasis. DDAH1 metabolizes the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA), while DDAH2 acts through ADMA-independent mechanisms. We synthesize current evidence from systemic studies, genetic analyses, postmortem brain samples, and animal models to evaluate the potential roles of DDAH proteins across psychiatric conditions. Most systemic studies have revealed increased peripheral ADMA levels across several psychiatric disorders, including schizophrenia, depression, bipolar disorder, substance use disorders, and attention-deficit/hyperactivity disorder. Alterations in ADMA levels are also observed in transdiagnostic clinical domains such as cognitive deficits, sleep disturbances, white matter hyperintensities, and oxidative stress. These ADMA changes are evident from early stages of illness and respond to current treatments, suggesting diagnostic potential. Genetic and postmortem brain data further link DDAH1 and DDAH2 to psychiatric symptomatology in patient populations. Finally, fundamental studies in model systems provide insights into their role in neural proliferation, differentiation, cell death, and oxidative stress regulation—key processes in the developing and the adult brain. These data support the view that DDAH proteins may play a role in the molecular mechanisms that underlie psychiatric disorders and merit more investigation as potential therapeutic candidates.

精神疾病的异质性使其临床管理和新治疗方法的发展复杂化，给患者和卫生保健系统都带来了沉重的负担。为了应对这些挑战，必须不断确定其发病机制中涉及的新靶点。在这篇叙述性综述中，我们提出了二甲基精氨酸二甲氨基水解酶（DDAH）蛋白，它已经在心血管疾病中发挥了重要作用，作为精神疾病有希望的新治疗靶点。DDAH蛋白存在2种亚型，即DDAH1和DDAH2，它们都能调节一氧化氮的稳态。DDAH1代谢一氧化氮合酶抑制剂不对称二甲基精氨酸（ADMA），而DDAH2通过ADMA独立的机制起作用。我们综合了来自系统研究、遗传分析、死后脑样本和动物模型的现有证据，以评估DDAH蛋白在精神疾病中的潜在作用。大多数系统研究表明，在多种精神疾病中，包括精神分裂症、抑郁症、双相情感障碍、物质使用障碍和注意缺陷/多动障碍，外周ADMA水平升高。ADMA水平的改变也可在认知缺陷、睡眠障碍、白质高信号和氧化应激等跨诊断临床领域观察到。这些ADMA变化从疾病的早期阶段就很明显，并对目前的治疗有反应，表明诊断潜力。遗传和死后脑数据进一步将DDAH1和DDAH2与患者群体的精神症状联系起来。最后，模型系统的基础研究提供了它们在神经增殖、分化、细胞死亡和氧化应激调节中的作用——发育和成人大脑的关键过程。这些数据支持这样一种观点，即DDAH蛋白可能在精神疾病的分子机制中发挥作用，作为潜在的治疗候选物值得更多的研究。

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引用次数: 0

Peripheral MicroRNA Expression Patterns as Biomarkers for Adolescent Depression 外周MicroRNA表达模式作为青少年抑郁症的生物标志物

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-08-22 DOI: 10.1016/j.bpsgos.2025.100571

Brunno Rocha Levone, Gerhard Schratt

引用次数: 0

Social Determinants of Health Influence Brain and Cognitive Function in Youth 影响青少年大脑和认知功能的社会因素

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-09-12 DOI: 10.1016/j.bpsgos.2025.100590

Lucina Q. Uddin

引用次数: 0

Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents 青少年早期生活不可预测性对海马体和杏仁核新奇反应的性别特异性影响

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-07-07 DOI: 10.1016/j.bpsgos.2025.100561

Elysia Poggi Davis , Bianca T. Leonard , Robert J. Jirsaraie , David B. Keator , Steven L. Small , Curt A. Sandman , Victoria B. Risbrough , Hal S. Stern , Laura M. Glynn , Michael A. Yassa , Tallie Z. Baram , Jerod M. Rasmussen

Background

Unpredictable childhood experiences are an understudied form of early-life adversity that impact neurodevelopment. The neurobiological processes by which exposure to early-life unpredictability impact development and vulnerability to psychopathology remain poorly understood. In the current study, we investigated the sex-specific consequences of early-life unpredictability on the limbic network, focusing on the hippocampus and the amygdala.

Methods

Participants included 150 youths (54% female). Early-life unpredictability was assessed using the Questionnaire of Unpredictability in Childhood (QUIC). Participants engaged in 1 or more task–functional magnetic resonance imaging scans between the ages of 8 and 17 (223 total observations) measuring blood oxygen level–dependent (BOLD) responses to novel and familiar scenes.

Results

Exposure to early-life unpredictability was associated with BOLD contrast (novel vs. familiar) in a sex-specific manner. For boys, but not girls, higher QUIC scores were associated with lower BOLD activation in response to novel versus familiar stimuli in the hippocampal head and amygdala. Secondary psychophysiological interaction analyses revealed complementary sex-specific associations between QUIC scores and condition-specific functional connectivity between the right and left amygdala, as well as between the right amygdala and hippocampus bilaterally.

Conclusions

Exposure to unpredictability in early life has persistent implications for the functional operations of limbic circuits. Importantly, consistent with emerging experimental animal and human studies, the consequences of early-life unpredictability differ for boys and girls. Furthermore, impacts of early-life unpredictability were independent of other risk factors including lower household income and negative life events, indicating distinct consequences of early-life unpredictability beyond more commonly studied types of early-life adversity.

不可预测的童年经历是影响神经发育的早期生活逆境的一种尚未得到充分研究的形式。暴露于早期生活的不可预测性影响发展和易患精神病理的神经生物学过程仍然知之甚少。在当前的研究中，我们研究了早期生活不可预测性对边缘网络的性别特异性影响，重点关注海马体和杏仁核。方法研究对象为青年150人（女性54%）。使用童年不可预测性问卷（QUIC）评估早期生活的不可预测性。参与者在8到17岁之间进行了一次或多次任务功能磁共振成像扫描（共223次观察），测量对新奇和熟悉场景的血氧水平依赖（BOLD）反应。结果暴露于早期生活的不可预测性与BOLD对比（新奇与熟悉）以性别特异性的方式相关。对于男孩，而不是女孩，较高的QUIC分数与海马体头部和杏仁核中对新刺激和熟悉刺激的较低的BOLD激活有关。二级心理生理相互作用分析显示，QUIC评分与左右杏仁核之间以及左右杏仁核和海马之间的条件特异性功能连接之间存在互补的性别特异性关联。结论生命早期暴露于不可预测的环境对大脑边缘回路的功能运作有持续的影响。重要的是，与新兴的动物和人类实验研究一致，早期生活不可预测性的后果对男孩和女孩来说是不同的。此外，早期生活不可预测性的影响独立于其他风险因素，包括较低的家庭收入和消极的生活事件，表明早期生活不可预测性的明显后果超出了更常见的早期生活逆境类型。

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The Clinical Relevance of Immunopsychiatric Treatment: Lessons From a Transdiagnostic Case Series on Young People 免疫精神病学治疗的临床意义：来自年轻人的跨诊断病例系列的经验教训

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Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-09-25 DOI: 10.1016/j.bpsgos.2025.100600

Luca Sforzini , Carmine M. Pariante

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IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-11-14 DOI: 10.1016/S2667-1743(25)00187-9

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