Biomedical engineering advances最新文献_第3页

Remineralization of demineralized teeth enamel with nHAp and nHAp-NaF-PEO nanocomposite nHAp和nHAp- naf - peo纳米复合材料对脱矿牙釉质的再矿化作用

Biomedical engineering advances

Pub Date : 2025-09-05 DOI: 10.1016/j.bea.2025.100192

Nazifa Zaman Khan , S. Manjura Hoque , Harinarayan Das , Arup Kumar , Rafiqul Islam , Mozammal Hossain

Teeth enamel, composed of calcium and phosphorus, becomes demineralized in contact with beverages and food. The essential component of teeth, enamel, can be remineralized with the use of nano-hydroxyapatite (nHAp) alone or in a solution consisting of nHAp, sodium fluoride (NaF), and polyethylene oxide (PEO) nanocomposite. We divided ten sound-extracted teeth into two groups: Group A consisted of three teeth treated with nHAp colloids, while Group B consisted of seven teeth treated with nHAp-NaF-PEO nanocomposite in solution. We demineralized the teeth of both groups by soaking them in various pH-adjusted demineralizing agents for different periods. We analyzed the morphology and composition of the demineralized teeth by the scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDAX). The teeth specimens were brushed two times/day for about 2 minutes each, with a 12-hours interval between brushing sessions, to remineralize them over four weeks. Periodically, the enamel specimens were placed in distilled water and maintained at 37° C in the CO₂ incubator. We analyzed the morphology and composition of the remineralized teeth by SEM and EDAX. The results show that the surface morphology produced by the nHAp-NaF-PEO nanocomposite solution was quite similar to the baseline enamel morphology. We observed an increase in mineral content, namely the Ca/P ratio, in the nHAp-NaF- PEO nanocomposite solution. The nHAp-NaF-PEO nanocomposite solution aids the remineralization of the decayed teeth more effectively than nHAp singly and heals carious lesions. Both nHAp and nHAp-NaF-PEO heals the morphology of carious teeth.

牙釉质由钙和磷组成，在接触饮料和食物时会发生脱矿。牙齿的基本组成部分，牙釉质，可以单独使用纳米羟基磷灰石（nHAp）或在由纳米羟基磷灰石、氟化钠（NaF）和聚乙烯氧化物（PEO）纳米复合材料组成的溶液中再矿化。我们将10颗拔音牙分为两组：A组3颗牙用nHAp胶体处理，B组7颗牙用nHAp- naf - peo纳米复合材料溶液处理。我们将两组的牙齿分别浸泡在不同ph值的脱矿剂中进行不同时间的脱矿。用扫描电镜（SEM）和能量色散x射线能谱（EDAX）分析脱矿牙的形态和成分。每天刷牙两次，每次约2分钟，每次刷牙间隔12小时，在四周内再矿化牙齿。定期将牙釉质标本置于蒸馏水中，并在37°C的CO2培养箱中保存。用扫描电镜（SEM）和电子能谱（EDAX）分析再矿化牙的形态和成分。结果表明，nHAp-NaF-PEO纳米复合溶液制备的牙釉质表面形态与基线牙釉质形态非常接近。我们观察到nHAp-NaF- PEO纳米复合溶液中矿物质含量的增加，即Ca/P比。nHAp- naf - peo纳米复合溶液比单一的nHAp更有效地帮助蛀牙的再矿化和修复龋齿。nHAp和nHAp- naf - peo对龋牙形态均有修复作用。

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引用次数: 0

Wearable near-infrared spectroscopy device to quantify rehabilitation following anterior cruciate ligament reconstruction: A case study on division I collegiate football athletes 可穿戴近红外光谱装置量化前十字韧带重建后的康复：以大学橄榄球甲级运动员为例

Biomedical engineering advances

Pub Date : 2025-09-05 DOI: 10.1016/j.bea.2025.100193

Joseph Amitrano , Milad Zarrinfar , Marco Giuliani , Kevin Cahill , Mark A. Seeley , Dhruv R. Seshadri

The anterior cruciate ligament (ACL) is critical for stabilizing the knee during high-performance activities. Anterior cruciate ligament reconstruction (ACLR) surgery, combined with rehabilitation, is the standard treatment for tears; however, determining readiness to return to sport (RTS) remains challenging. Traditional RTS assessments often fail to capture physiological recovery, emphasizing the need for precise, objective biomarkers. Near-infrared spectroscopy (NIRS) offers real-time, non-invasive insights into muscle oxygen saturation, providing an objective means to quantify recovery. This study investigated the utility of a wearable NIRS sensor to monitor muscle oxygen saturation levels in two Division 1 football athletes recovering from a torn ACL, with a focus on assessing inter-athlete recovery variability and its implications for RTS decisions. This longitudinal case study monitored muscle oxygen saturation using the Moxy Muscle Oxygen Monitor in the surgical and contralateral legs of two athletes at 1, 3-, 5-, 6-, and 7-months post-surgery during functional exercises (leg raises and quad sets). The study highlights the capacity of NIRS based wearable sensors to capture inter-individual variability over the rehabilitation continuum towards providing real-time physiological insights beyond traditional subjective or qualitative-based assessments. These findings support the integration of wearable technology into lower extremity rehabilitation protocols to enhance recovery evaluations and improve athlete RTS.

前交叉韧带（ACL）是在高性能活动中稳定膝盖的关键。前交叉韧带重建（ACLR）手术结合康复是治疗撕裂的标准方法；然而，决定玩家是否准备好回归游戏（RTS）仍然具有挑战性。传统的RTS评估往往不能捕捉生理恢复，强调需要精确、客观的生物标志物。近红外光谱（NIRS）提供了实时、无创的肌肉氧饱和度信息，为量化恢复提供了客观手段。本研究调查了可穿戴近红外光谱传感器监测两名甲级足球运动员前交叉韧带撕裂后恢复的肌肉氧饱和度水平的实用性，重点评估了运动员间恢复的可变性及其对RTS决策的影响。本纵向病例研究使用Moxy肌肉氧监测仪监测两名运动员手术后1、3、5、6和7个月的对侧腿和对侧腿的肌肉氧饱和度。该研究强调了基于近红外光谱的可穿戴传感器在康复连续体中捕捉个体间差异的能力，从而提供了超越传统主观或基于定性的评估的实时生理洞察。这些发现支持将可穿戴技术整合到下肢康复方案中，以增强恢复评估并改善运动员RTS。

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引用次数: 0

A core needle biopsy combined with novel spectroscopic probe for in vivo tissue classification – A pilot study on piglets 核心针活检结合新型光谱探针进行体内组织分类-仔猪的初步研究

Biomedical engineering advances

Pub Date : 2025-09-02 DOI: 10.1016/j.bea.2025.100191

Lukasz Surazynski , Jyri Järvinen , Martti Ilvesmäki , Markus Mäkinen , Heikki J. Nieminen , Miika T. Nieminen , Teemu Myllylä

Tissue sampling is a primary goal of core needle biopsies (CNB), cancer therapy evaluation, and autoimmune disease assessment. Conventional guidance methods such as ultrasound and MRI suffer from periprocedural tissue‐type insensitivity in complex biopsy targets, motion sensitivity, imaging artifacts and high costs, which may limit their usefulness. Accurate tissue classification and needle guidance during CNB are equally important. Mistakes may lead to sample inadequacies, obscured results, incorrect sampling spots, and ultimately repeated biopsies. To address these challenges, this study investigates the feasibility of a smart CNB probe integrating real-time optical spectroscopy for enhanced tissue characterization during in vivo biopsy utilizing machine learning methods. Ten fabricated probes were tested in vivo on porcine fat, liver, and kidney tissues, demonstrating potential for improving biopsy accuracy. Acquired spectral data enabled effective tissue differentiation, as indicated by the best-performing classification models. LDA classifier with MRMR feature selection reached sensitivity of 87.3 % in classification between liver and fat tissues, where SVM with linear kernel and PCA reached 86.4 % sensitivity in kidney vs fat. These findings suggest that integrating optical spectroscopy into CNB procedures may enhance diagnostic accuracy while mitigating procedural risks.

组织取样是核心针活检（CNB）、癌症治疗评估和自身免疫性疾病评估的主要目标。传统的引导方法，如超声和MRI，在复杂的活检目标中存在围手术期组织类型不敏感、运动敏感、成像伪影和高成本等问题，这可能限制了它们的实用性。在CNB过程中，准确的组织分类和针头引导同样重要。错误可能导致样本不足，结果模糊，采样点不正确，最终导致重复活检。为了解决这些挑战，本研究探讨了智能CNB探针集成实时光谱学的可行性，利用机器学习方法在活体活检过程中增强组织表征。在猪脂肪、肝脏和肾脏组织中对10个制备的探针进行了体内测试，证明了提高活检准确性的潜力。所获得的光谱数据能够有效地进行组织分化，正如性能最好的分类模型所示。具有MRMR特征选择的LDA分类器在肝脏和脂肪组织之间的分类灵敏度达到87.3%，而具有线性核和PCA的SVM在肾脏和脂肪之间的分类灵敏度达到86.4%。这些发现表明，将光谱学整合到CNB程序中可以提高诊断准确性，同时降低程序风险。

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引用次数: 0

The influence of countermovement depth on joint coordination and ground reaction force waveform in countermovement jump 反动作深度对反动作跳跃关节配合及地面反作用力波形的影响

Biomedical engineering advances

Pub Date : 2025-08-21 DOI: 10.1016/j.bea.2025.100190

Mona Makita, Shinichi Kawamoto, Momoko Nagai-Tanima, Tomoki Aoyama

The ground reaction force (GRF) waveform during countermovement jumps (CMJs) is considered to reflect neuromuscular coordination strategies; yet the biomechanical mechanisms distinguishing unimodal from bimodal patterns remain unclear. This study investigated the influence of countermovement depth and velocity on GRF waveform shape and examined their relationship with joint moments and work. Twenty-six healthy young women (age: 22.1 ± 1.1 years; height: 160.8 ± 4.0 cm; body weight: 53.5 ± 5.6 kg) performed CMJs, and GRF waveforms were categorised as unimodal and bimodal patterns. Jump-related variables, joint moments, and work were analysed. Analysis of covariance (ANCOVA) was conducted using countermovement depth as a covariate, and correlation analyses examined the associations between depth and biomechanical parameters. Compared with the unimodal group, the bimodal group exhibited a significantly greater countermovement depth, with no significant difference in countermovement velocity. Before adjustment, knee joint work and ankle joint moments differed significantly between groups; however, these differences were no longer evident after adjusting for countermovement depth, indicating that it was a confounding factor. Correlation analyses demonstrated that a greater countermovement was associated with increased hip and knee joint work and reduced ankle joint contribution. These findings indicate that GRF waveform shape in CMJ is determined primarily by countermovement depth rather than velocity. The unimodal pattern reflected ankle-dominant simultaneous output, whereas the bimodal pattern reflected proximal joint-dominant sequential output. This study highlights the role of joint-specific coordination strategies and offers insight for developing individualised training and rehabilitation approaches.

反动作跳跃（CMJs）时的地面反作用力（GRF）波形被认为反映了神经肌肉协调策略；然而，区分单峰与双峰模式的生物力学机制仍不清楚。研究了反运动深度和反运动速度对GRF波形形态的影响，并考察了反运动深度和反运动速度与关节力矩和功的关系。26名健康年轻女性（年龄：22.1±1.1岁，身高：160.8±4.0 cm，体重：53.5±5.6 kg）进行了CMJs， GRF波形分为单峰和双峰两种。分析了跳跃相关变量、关节力矩和功。采用反运动深度作为协变量进行协方差分析（ANCOVA），相关分析考察深度与生物力学参数之间的关系。与单峰组相比，双峰组的反动作深度显著增加，反动作速度无显著差异。调整前，两组间膝关节功、踝关节力矩差异有统计学意义；然而，在调整了反向移动深度后，这些差异不再明显，表明这是一个混杂因素。相关分析表明，更大的反向运动与髋关节和膝关节工作增加和踝关节贡献减少有关。这些结果表明，CMJ中的GRF波形形状主要由反运动深度而不是速度决定。单峰模式反映踝关节为主的同时输出，而双峰模式反映近端关节为主的顺序输出。这项研究强调了特定关节协调策略的作用，并为制定个性化的训练和康复方法提供了见解。

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引用次数: 0

A novel frequency-domain approach to the range migration algorithm for efficient medical image processing: Application in tumor detection and identification 一种有效医学图像处理的距离迁移频域新方法：在肿瘤检测与识别中的应用

Biomedical engineering advances

Pub Date : 2025-08-09 DOI: 10.1016/j.bea.2025.100189

Jaouad El Gueri , Ibtisam Amdaouch , Badiaa Ait Ahmed , Juan Ruiz-Alzola , Otman Aghzout

This paper introduces a novel, computationally efficient range migration algorithm (RMA) specifically designed for medical microwave imaging applications. The proposed RMA achieves significant advancements over traditional methods, such as the Delay Multiply and Sum technique, by greatly reducing channel calculations and computational time while maintaining high image quality. The algorithm was validated using an antenna array system and a custom built phantom model. To further reduce noise and image artifacts after RMA application, Hamming, Gaussian, and Median filtering techniques were applied and compared. Notably, the Hamming filter significantly enhanced edge sharpness and improved tumor detection within human tissue compared to the other filters. A comprehensive complexity analysis was conducted to evaluate the algorithm’s efficiency and scalability, with a focus on computational time and resource utilization. Performance results offer valuable insights into the algorithm’s behavior across various operational conditions, Highlighting its potential to enhance healthcare diagnostics and improve patient outcomes, with promising prospects for future clinical adoption.

本文介绍了一种新的、计算效率高的距离迁移算法（RMA），该算法是专门为医学微波成像应用而设计的。所提出的RMA在保持高图像质量的同时，大大减少了信道计算和计算时间，大大优于延迟乘法和和技术等传统方法。采用天线阵列系统和自定义模型对算法进行了验证。为了进一步减少RMA应用后的噪声和图像伪影，采用了Hamming、高斯和中值滤波技术并进行了比较。值得注意的是，与其他滤波器相比，汉明滤波器显著增强了边缘清晰度，并改善了人体组织内的肿瘤检测。以计算时间和资源利用率为重点，对算法的效率和可扩展性进行了全面的复杂性分析。性能结果为该算法在各种操作条件下的行为提供了有价值的见解，突出了其增强医疗保健诊断和改善患者结果的潜力，并具有未来临床应用的良好前景。

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引用次数: 0

Current challenges and bioengineering aspects in the development of an in vitro model of the human intestinal epithelium 目前的挑战和生物工程方面的发展，在体外模型的人肠上皮

Biomedical engineering advances

Pub Date : 2025-07-04 DOI: 10.1016/j.bea.2025.100188

Jhonatan Rafael de Oliveira Bianchi , Ana Letícia Rodrigues Costa , Hernandes F. Carvalho , Lucimara Gaziola de La Torre

The human intestinal epithelium is a multitasking tissue with different cell types and a complex architecture responsible for molecules/nutrient absorption during food digestion, and working as a physical barrier to the infection of pathogens. Symbiosis with the microbiota regulates metabolic pathways accountable for developing diseases, for example diabetes, obesity, and cancer. Therefore, several in vitro biology-inspired physiological models have been developed to humanize drug tests and study cell behavior. This review uses a design approach to discuss the essential bioengineering parameters required to design an intestinal epithelium microphysiological system (MPS) rationally. Important project parameters are discussed, considering the biological question in hands, hydrogel microenvironment, and relevant engineering criteria to observe and quantify the functionality of this epithelium. Thus, we will focus on recent bioengineering aspects related to the fabrication of the intestine model, such as how the biomaterial (matrix) proprieties (porosity, mechanical force, and curvature) affect the cell behavior and, consequently, the characteristics of in vitro intestinal models. Moreover, the technological approaches used to create a villus-like microarchitecture, lithography, and 3D bioprinting are introduced. Finally, combining villi-crypt microarchitecture with fluid perfusion and hypoxia is discussed to create a more complex intestine-MPS.

人类肠上皮是一个多任务组织，具有不同的细胞类型和复杂的结构，负责食物消化过程中的分子/营养吸收，并作为病原体感染的物理屏障。与微生物群的共生调节了代谢途径，这些代谢途径导致了糖尿病、肥胖和癌症等疾病的发生。因此，一些体外生物学启发的生理模型已经开发出人性化的药物测试和研究细胞行为。本文采用设计方法讨论了合理设计肠上皮微生理系统（MPS）所需的基本生物工程参数。考虑到手头的生物学问题、水凝胶微环境和相关的工程标准，讨论了重要的项目参数，以观察和量化该上皮的功能。因此，我们将关注最近与肠模型制造相关的生物工程方面，例如生物材料（基质）特性（孔隙度、机械力和曲率）如何影响细胞行为，从而影响体外肠模型的特征。此外，还介绍了用于创建绒毛样微结构、光刻和3D生物打印的技术方法。最后，讨论了绒毛-隐窝微结构与流体灌注和缺氧相结合，以创建更复杂的肠- mps。

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引用次数: 0

BLVQE: Blind Laparoscopic Video Quality Evaluator using spatio-temporal interdependency and textural cues 使用时空相互依赖和纹理线索的盲腹腔镜视频质量评估器

Biomedical engineering advances

Pub Date : 2025-06-16 DOI: 10.1016/j.bea.2025.100184

Sria Biswas, Rohini Palanisamy

Quality assessment of laparoscopic videos is critical for ensuring accurate diagnostics and surgical precision. Traditional quality assessment methods typically focus on either spatial or textural features independently, limiting their effectiveness in handling composite distortions like motion blur, noise, defocus blur, uneven illumination, and smoke. To address this, leveraging spatio-temporal interdependencies and textural features offers a more comprehensive approach in replicating the human visual system to improve the robustness of video quality assessment. This work introduces Blind Laparoscopic Video Quality Evaluator (BLVQE) that models the statistical interdependencies between spatial, temporal and texture features. For this, laparoscopic videos obtained from a public database are used to estimate the Luminance and motion vector maps, which are then analyzed using bivariate generalized Gaussian distribution to capture spatio-temporal interdependency. Scene texture complexity is further quantified using statistical energy measures. These feature vectors are used for end-to-end training of an LSTM framework for frame quality predictions. The training and validation loss curves of the model saturate around 50 epochs, indicating prediction proficiency. BLVQE predictions show a high correlation with subjective scores exhibiting robust and competitive performance against other state-of-the-art methods. Ablation studies highlight the contribution of individual feature elements, confirming the superiority of the selected features. These findings enhance the understanding of the spatial, temporal and textural variations that influence video quality and highlight the potential of joint dependencies in accurately estimating the diagnostic quality of laparoscopic videos.

腹腔镜视频的质量评估是确保准确诊断和手术精度的关键。传统的质量评估方法通常单独关注空间或纹理特征，限制了它们在处理运动模糊、噪声、散焦模糊、光照不均匀和烟雾等复合失真方面的有效性。为了解决这个问题，利用时空相互依赖性和纹理特征提供了一种更全面的方法来复制人类视觉系统，以提高视频质量评估的鲁棒性。本文介绍了盲腹腔镜视频质量评估器（BLVQE），该工具对空间、时间和纹理特征之间的统计相关性进行建模。为此，使用从公共数据库获取的腹腔镜视频来估计亮度和运动矢量图，然后使用二元广义高斯分布对其进行分析，以捕获时空相互依赖性。使用统计能量度量进一步量化场景纹理复杂性。这些特征向量用于LSTM框架的端到端训练，用于帧质量预测。模型的训练和验证损失曲线在50次左右达到饱和，表明预测能力较强。与其他最先进的方法相比，BLVQE预测显示出与主观得分的高度相关性，表现出稳健和有竞争力的表现。消融研究强调了单个特征元素的贡献，证实了所选特征的优越性。这些发现增强了对影响视频质量的空间、时间和纹理变化的理解，并强调了在准确估计腹腔镜视频诊断质量方面联合依赖的潜力。

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引用次数: 0

Technological enhancements in personalized dietary management for chronic conditions 慢性病个性化饮食管理的技术改进

Biomedical engineering advances

Pub Date : 2025-06-13 DOI: 10.1016/j.bea.2025.100181

Tania Tahtouh , Hadil Salman , Nermin Eissa , Najla Al Nassar , Sofyan Maghaydah , Marah Alhalabi , Maha Yaghi , Abdalla Gad , Dana Abdallah , Salma Elberry , Aysha Alhosani , Shaikha Alshehhi , Mohammad Alkhedher , Mohamad Ramadan , Mohammed Ghazal

Dietary compliance plays a vital role in the control of chronic diseases and influences response to therapy. The rapid development experienced nowadays through smart technology has enabled the personalization of dietary advice to meet individual needs. This paper provides an overview of the current technological solutions to dietary adherence among patients with chronic conditions. With the increasing prevalence of chronic diseases requiring diet-specific interventions, this review encompasses mobile apps and wearables to IoT-based devices and generative intelligence tools, including chatbots, aimed at offering specific guidance as well as providing individualized support for dietary requirements. This review provides an overview of the strengths and limitations of these approaches in real world applications, as well as emerging methodologies that attempt to improve this by focusing on means to personalize dietary management more effectively. The study suggests that technology-enabled dietary interventions can be useful to support chronic disease management and generative artificial intelligence may have a profound effect on the further personalization of dietary guidance. However, issues surrounding regulatory alignment, content validity and long-term user engagement remain to be resolved in order to maximize the tools’ functionality in clinical and home settings.

饮食依从性在控制慢性疾病中起着至关重要的作用，并影响对治疗的反应。如今，通过智能技术的快速发展，使饮食建议个性化，以满足个人需求。本文概述了目前的技术解决方案，以饮食依从性的慢性病患者。随着需要特定饮食干预的慢性病的日益流行，本综述涵盖了移动应用程序和可穿戴设备到基于物联网的设备和生成智能工具，包括聊天机器人，旨在提供具体指导以及为饮食需求提供个性化支持。这篇综述概述了这些方法在实际应用中的优势和局限性，以及新兴的方法，这些方法试图通过关注更有效地个性化饮食管理的方法来改进这一点。该研究表明，技术支持的饮食干预可能有助于支持慢性疾病管理，而生殖人工智能可能对饮食指导的进一步个性化产生深远影响。然而，为了在临床和家庭环境中最大限度地发挥工具的功能，围绕监管一致性、内容有效性和长期用户参与的问题仍有待解决。

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引用次数: 0

Noninvasive monitoring of changes in intracranial fluid and tissue composition 颅内液体和组织成分变化的无创监测

Biomedical engineering advances

Pub Date : 2025-06-13 DOI: 10.1016/j.bea.2025.100187

Andrea Boraschi , Andreas Spiegelberg , Vartan Kurtcuoglu

Continuous assessment of changes in the fluid and tissue composition of the brain, as they occur with certain space-occupying disorders, is currently not possible. Recently, the noninvasive acquisition of the head’s dielectric properties has been proposed as the basis for monitoring such changes. The analysis of the corresponding electric signal, referred to as W, focused so far on intracranial fluid volume changes induced by cardiorespiratory action. Here, we report on a novel approach to acquire changes of W also in the 0 to 0.1 Hz frequency range, which would allow capturing slower processes such as edema formation. Six healthy male volunteers were tilted head-up, head-down, and subjected to bilateral jugular vein compression. W decreased during head-up tilting, while it increased during head-down tilting and jugular vein compression. These findings are consistent with anticipated changes in intracranial volume due to these maneuvers, notably the reduction of intracranial blood volume during head-up tilt and its augmentation during head-down tilt and jugular vein compression. This study provides a proof of principle for the detection of changes in W within the 0–0.1 Hz frequency range, broadening the potential clinical utility of noninvasive monitoring of cranial dielectric properties in diagnosing and managing space-occupying disorders.

目前还不可能像某些占位性疾病那样，对大脑液体和组织组成的变化进行持续评估。最近，人们提出了无创获取头部介电特性作为监测这种变化的基础。到目前为止，对相应电信号（简称W）的分析主要集中在心肺作用引起的颅内液量变化上。在这里，我们报告了一种新的方法来获取0到0.1 Hz频率范围内W的变化，这将允许捕获较慢的过程，如水肿的形成。6名健康男性志愿者头朝上、头朝下倾斜，并接受双侧颈静脉压迫。俯仰时W值降低，俯仰和颈静脉压迫时W值升高。这些发现与预期的颅内容量变化是一致的，由于这些动作，特别是在头向上倾斜时颅内血容量减少，而在头向下倾斜和颈静脉压迫时颅内血容量增加。该研究为检测0-0.1 Hz频率范围内W的变化提供了原理证明，扩大了无创监测颅骨介电特性在诊断和治疗占位性疾病中的潜在临床应用。

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引用次数: 0

Tracking orthodontic tooth movement and associated biomechanics using an integrated clinical and in vitro mechanical approach 使用综合临床和体外机械方法跟踪正畸牙齿运动和相关的生物力学

Biomedical engineering advances

Pub Date : 2025-06-13 DOI: 10.1016/j.bea.2025.100186

Arya Subramanian , Robyn de Wet , Lingyu Bu , Manuel O. Lagravere , Paul W. Major , Dan L. Romanyk

The objective of this study was to establish an integrated clinical and in vitro experimental approach to track tooth positions and replicate digital tooth positions in vitro for biomechanical load measurement over orthodontic treatment. Patients between 11–14 years were recruited to collect four digital intraoral scans in 4–6-week intervals. Patients were treated for mild anterior crowding using 0.022″ Damon Q2 brackets and CuNiTi round archwires sized up at each treatment interval (T1-T2: 0.014″, T2-T3: 0.016″, T3-T4: 0.018″). Scans were superimposed and clinical tooth movement was tracked using bracket-slot midpoint position differences. An in-house workflow was developed using MATLAB and SolidWorks to replicate digital bracket positions on an Orthodontic Simulator (OSIM) with custom-dimensioned jigs. Mechanical experiments for the sample arches were performed at 37°C for 3D force measurements at each tooth upon wire insertion (n = 5/archwire size). The average superimposition error between T2-T4 and T1 scans was 0.19 mm. Average errors in bracket position replication across all directions was 0.41 mm in the local X-, Y-, and Z-direction, respectively. The initial force and tooth movement range was 0.00–1.43 N and 0.01–1.81 mm in the Y-direction, and 0.01–2.17 N and 0.00–1.45 mm in the Z-direction. Tooth movement ranged from 0.00–0.30 mm/week in the Y-direction and 0.00–0.24 mm/week in the Z-direction over treatment. This study developed a process to measure clinical tooth movement and existing force/moment systems for sample arches over orthodontic braces treatment. Future work will involve an expanded data set to establish fundamental relationships between force systems and clinical tooth movements.

本研究的目的是建立一种综合的临床和体外实验方法来跟踪牙齿位置，并在体外复制数字牙齿位置，用于正畸治疗期间的生物力学载荷测量。招募11-14岁的患者，每隔4 - 6周收集4次数字口内扫描。患者使用0.022″Damon Q2托架和CuNiTi圆形弓丝治疗轻度前路拥挤（T1-T2: 0.014″，T2-T3: 0.016″，T3-T4: 0.018″）。将扫描结果进行叠加，并利用托槽中点位置差跟踪临床牙齿运动。利用MATLAB和SolidWorks开发了一个内部工作流程，在具有定制尺寸夹具的正畸模拟器（OSIM）上复制数字支架位置。在37°C的温度下对样品弓进行力学实验，测量每个牙齿插入金属丝时的三维力（n = 5/弓丝尺寸）。T2-T4与T1扫描的平均叠加误差为0.19 mm。在局部X、Y和z方向上，所有方向上支架位置复制的平均误差分别为0.41 mm。初始力和齿的运动范围分别为：y方向为0.00-1.43 N和0.01-1.81 mm， z方向为0.01-2.17 N和0.00-1.45 mm。在治疗过程中，牙齿在y方向上的移动幅度为0.00-0.30 mm/周，在z方向上的移动幅度为0.00-0.24 mm/周。本研究开发了一个过程来测量临床牙齿运动和现有的力/力矩系统的样本弓在正畸牙套治疗。未来的工作将包括扩展数据集，以建立力系统和临床牙齿运动之间的基本关系。

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引用次数: 0