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Prediction of Severity of Acute Pancreatitis by Biochemical Markers: A Tertiary Care Hospital Study 生化指标预测急性胰腺炎严重程度:一项三级医院研究
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.132
Shanjidah Hoque, Rifat Hassan, Naheen Rezuan Shehran Asif
Background: Acute pancreatitis (AP) is an acute inflammatory condition of the pancreas which may extend to local and distant extra pancreatic tissues. It is a life-threatening disease that has many causes, few effective treatments and numerous serious complications. Early diagnosis of acute pancreatitis and effective treatment can significantly reduce the mortality and morbidity of such cases.
背景:急性胰腺炎(AP)是胰腺的一种急性炎症,可扩展到局部和远处胰腺外组织。这是一种危及生命的疾病,有许多病因,很少有有效的治疗方法和许多严重的并发症。急性胰腺炎的早期诊断和有效治疗可显著降低此类病例的死亡率和发病率。
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引用次数: 0
Prevalence and Risk Factors of Gestational Diabetes Mellitus in Likasi, in The Democratic Republic of The Congo: A Preliminary Study 在利卡西,在刚果民主共和国妊娠糖尿病的患病率和危险因素:初步研究
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.137
Hénoch Kabala Tshasuma, Chamy Lubamba Cham, Joseph Bulanda Nsambi, Charles Wembonyama Mpoy
Objective: To determine the prevalence and identify risk factors for gestational diabetes mellitus (GDM) in Likasi City in the Democratic Republic of the Congo.
目的:了解刚果民主共和国利卡西市妊娠期糖尿病(GDM)患病率及危险因素。
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引用次数: 0
Validation of CTP, MELD & MELD Na Scoring Systems for Predicting Treatment Outcome of Cirrhotic patients in Bangladesh- An observational study 验证CTP, MELD和MELD Na评分系统预测孟加拉国肝硬化患者治疗结果-一项观察性研究
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.115
Syeda Nur-E-Jannat, Dewan Saifuddin Ahmed
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引用次数: 0
Metadichol; An Agonist that Expresses the Anti-aging gene Klotho in Various Cell Lines Metadichol;在多种细胞系中表达抗衰老基因Klotho的激动剂
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.135
Palayakotai R. Raghavan
Klotho is a well-known tumor suppressor hormone that exhibits anti-cancer and anti-aging properties. Klotho levels are low or non-existent in cancer patients. Klotho protein levels decrease with aging; maintaining consistent levels may prevent disease and promote healthier aging. Metadichol is a nanoemulsion of long-chain alcohols C26, C28, and C30, of which C-28 constitutes over 85%. Any small molecule that can elevate Klotho can, in principle, help reverse many diseases in which Klotho levels are low. Previously, we showed that treatment of the pancreatic cancer cell lines PANC1, MIA-PACA, and COLO-205, combined with Metadichol, a lipid emulsion consisting of long-chain alcohols at 1-100 pg/mL concentrations, resulted in a 4- to 10-fold increase in Klotho expression as determined by qRT-PCR, This study aimed to demonstrate that Metadichol promotes Klotho expression in a wide variety of cell lines, such as primary cancer, stem, and somatic cell lines. Cells were treated with various concentrations of Metadichol ranging from 1 pg (picogram) to 1µg 9microgram). Three-to-fifteen-fold increase in Klotho expression was observed compared with baseline, as measured by qRT-PCR and qualified by western blot analysis. Metadichol is a natural agonist of Klotho expression and is non-toxic at levels up to 5000 mg/kg in rats. and has a potential therapeutic role in cancer and reversing aging.
Klotho是一种众所周知的肿瘤抑制激素,具有抗癌和抗衰老的特性。癌症患者体内的Klotho水平很低或根本不存在。Klotho蛋白水平随年龄增长而降低;保持稳定的水平可以预防疾病,促进健康老龄化。Metadichol是由C26、C28、C30三种长链醇组成的纳米乳液,其中C28占85%以上。原则上,任何可以提高Klotho水平的小分子都可以帮助逆转许多Klotho水平低的疾病。先前,我们发现胰腺癌细胞系PANC1、MIA-PACA和COLO-205与Metadichol(一种由长链醇组成的脂质乳剂,浓度为1-100 pg/mL)联合处理后,通过qRT-PCR检测,Klotho的表达增加了4- 10倍。本研究旨在证明Metadichol促进了Klotho在多种细胞系中的表达,如原发性癌、干细胞和体细胞系。细胞用不同浓度的Metadichol处理,浓度从1 pg(皮克)到1µg(微克)不等。与基线相比,通过qRT-PCR检测和western blot分析,观察到Klotho表达增加了3至15倍。Metadichol是一种天然的Klotho表达激动剂,在大鼠中高达5000 mg/kg的水平是无毒的。对癌症和逆转衰老有潜在的治疗作用。
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引用次数: 0
Methylmalonic acidemia caused by Homozygous Missense variant c.1837C>T in Exon 11 of the MMUT gene which is Variant of Uncertain Significance: A Case Report MMUT基因第11外显子纯合错义变异c.1837C>T引起的甲基丙二酸血症,该变异意义不确定:1例报告
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.106
G. Phani Kumar, Mashingbonio Dirinamai, B. Manishkumar, Susheel kumar saini, Ajay kumar saini, S. Kumari
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引用次数: 0
Prevalence of Methicillin-Resistant Staphylococcus Aureus with Their Susceptibility Pattern and Their Association of Panton-Valentine Leukocidin Gene in a Tertiary Care Hospital in Bangladesh 孟加拉国某三级医院耐甲氧西林金黄色葡萄球菌的流行、易感模式及其与潘通-瓦伦丁白细胞介素基因的关系
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.111
R. Khatun, Sk. Shehab Hasan, S. Akter, N. Khatun
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引用次数: 0
Evolution of The Main Hospital Activity Indicators in Sikasso Hospital, Mali, 2015-2021 2015-2021年马里西卡索医院主要医院活动指标的演变
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.118
Dadé Ben Sidi Haidara, B. K, C. A, Traoré Ak, Traore Sa, T. L, Coulibaly Mb, K. M, Diallo Ab, T. B, T. T, Poma H, T. M
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引用次数: 0
Somatic Cell-Fusion and/or Co-Culturing: A Mechanism for Cell Re-Programming Prior to Cell Therapy of Neurodegenerative Diseases 体细胞融合和/或共培养:神经退行性疾病细胞治疗前的细胞重编程机制
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.094
A. Chakraborty, Anil Diwan
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引用次数: 0
Low Serum Magnesium Level is Associated with Hypertension in Bangladeshi Adults 孟加拉成人低血镁水平与高血压相关
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.095
Rahman Smr, Rahman As, Pramanik Ak, B. R, Rahim Ka, Yesmin Ms, Bhuiyan Mma, Islam Mt, R. M, Islam Ms, Sultana T
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引用次数: 0
Chronic, Massive Pneumoperitoneum in a Patient without Signs of Peritonitis 无腹膜炎征象的慢性大量气腹患者
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.096
M. Kubina, M. Mouchli
Received: January 18, 2023 Accepted: January 27, 2023 Published: February 10, 2023 Abstract Pneumoperitoneum is the presence of air in the abdomen. This can be due to a wide variety of etiologies, many of which are surgical emergencies, yet it can also present as a chronic symptom of underlying pathology. Pneumoperitoneum can be due to primary (idiopathic) or secondary causes, of which the causes are numerous. This can even be due to other pathology unrelated to the GI tract, such as pathology of the thoracic cavity. We present a case of chronic pneumatosis intestinalis that was due to peritoneal blebs likely secondary to an alveolar-peritoneal fistula through the right hemidiaphragm. Chronic, Massive Pneumoperitoneum in a Patient without Signs of Peritonitis
收稿日期:2023年1月18日接受日期:2023年1月27日发表日期:2023年2月10日摘要气腹是指腹部存在空气。这可能是由于各种各样的病因,其中许多是外科急诊,但它也可以表现为潜在病理的慢性症状。气腹可由原发性(特发性)或继发性原因引起,其中原因很多。这甚至可能是由于其他与胃肠道无关的病理,如胸腔的病理。我们报告一例慢性肠性肺肿,是由于腹膜泡可能继发于肺泡-腹膜瘘通过右半隔膜。无腹膜炎征象的慢性大量气腹患者
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引用次数: 0
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Fortune journal of health sciences
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