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An Update on the Epidemiology of Noma (Facial Gangrene) in Ethiopia 埃塞俄比亚Noma(面部坏疽)流行病学最新进展
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.105
Heron Gezahegn Gebretsadik
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引用次数: 0
Behavioral Public Health Policy and The Aftermath of the COVID-19 Pandemic: Should Governments Change Their Paradigm? 行为公共卫生政策和COVID-19大流行的后果:政府应该改变他们的模式吗?
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.114
Matteo Maria Cati
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引用次数: 0
STRA6: The key to inflammatory pathways in COVID-19 STRA6: COVID-19炎症通路的关键
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.098
Aziz Rodan Sarohan
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引用次数: 0
Evaluating the Ethics and Efficacy of Italy's Pandemic Policies 评估意大利流行病政策的伦理性和有效性
Pub Date : 2023-01-01 DOI: 10.26502/fjhs.139
Matteo Maria Cati
The COVID-19 pandemic has posed an unprecedented challenge to public health systems worldwide. Italy, one of the countries hardest hit by the pandemic early on, responded with a comprehensive policy landscape that leveraged the power of behavioral and social sciences. At the heart of this strategy lay the "green pass" system, a digital certificate that required proof of vaccination, recovery, or a negative test for access to public spaces. This study critically evaluates the impact of Italy's pandemic policies on vaccination rates, with a particular focus on the transformative influence of the green pass system. Drawing upon a rich tapestry of behavioral interventions rooted in behavioral economics, cognitive psychology, and social theory, we unravel the nuanced interplay of human behavior and policy design. Our investigation reveals a striking success story—an exponential surge in vaccination rates, particularly among previously hesitant demographics, propelled by the shrewd orchestration of behavioral nudges and informed policy architecture. The green pass, an epitome of behavioral science in action, wielded powerful cognitive nudges, skillfully circumventing cognitive biases and leveraging heuristics, leading to a significant rise in vaccination uptake. However, we do not shy away from confronting the ethical dilemma at the heart of this success—finding the delicate balance between public health imperatives and individual civil liberties. This academic exploration, intricately woven with empirical data, theoretical underpinnings, and interdisciplinary insights, endeavors to present a comprehensive, multifaceted evaluation. It aims to unravel the narrative threads that intertwine policy measures, behavioral interventions, public health outcomes, and the ethical compass during a global health crisis.
COVID-19大流行给全球公共卫生系统带来了前所未有的挑战。意大利是早期受疫情影响最严重的国家之一,采取了综合政策,充分利用了行为科学和社会科学的力量。这一战略的核心是“绿色通行证”系统,这是一种数字证书,需要疫苗接种、康复或阴性检测证明才能进入公共场所。本研究批判性地评估了意大利大流行政策对疫苗接种率的影响,特别关注绿色通行证制度的变革性影响。利用植根于行为经济学、认知心理学和社会理论的丰富的行为干预,我们揭示了人类行为和政策设计之间微妙的相互作用。我们的调查揭示了一个惊人的成功故事——在行为推动和知情政策架构的巧妙配合下,疫苗接种率呈指数级增长,特别是在以前犹豫不决的人口中。绿色通行证是行为科学在行动中的一个缩影,它运用了强大的认知推动,巧妙地规避了认知偏见,利用了启发式,导致疫苗接种率大幅上升。然而,我们并不回避面对这一成功的核心道德困境——在公共卫生需要和个人公民自由之间找到微妙的平衡。这一学术探索,与经验数据,理论基础和跨学科的见解交织在一起,努力提出一个全面的,多方面的评估。它旨在解开在全球卫生危机期间交织在一起的政策措施、行为干预、公共卫生结果和道德指南针的叙事线索。
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引用次数: 0
The Relationship between Heel Fat Pad Thickness and Flexibility and Physical Demographics 足跟脂肪垫厚度与柔韧性的关系及体质统计学
Pub Date : 2022-01-01 DOI: 10.26502/fjhs.088
Kazuaki Kinoshita, T. Hananouchi, Masayuki Fukuda, Mai Kitagawa, Mika Hirata
To clarify the factors that contribute to the development of heel pain in young individuals, this study investigated the relationship of heel thickness and flexibility with physical demographics among Japanese elementary and junior high school students. A total of 69 heels were included as participants in this study. The measurement items were age, height, weight, rohrer index, heel fat pad thickness and flexibility. The heel fat pad thickness and flexibility was measured using an ultrasound probe and S oftgram (Shinko Denshi co.,ltd.). The heel fat pad thickness measurements were distance from the skin to the calcaneus was measured by applying the ultrasound probe both without (hereafter referred to as "non-pressure thickness") and with manually applied pressure to the measurement point (hereafter referred to as “pressure thickness”) . The heel fat pad flexibility evaluation consisted of subtracting non-pressure thickness by pressure thickness (thickness of change difference), and computing for the value when the thickness of change difference is divided by the non-pressure thickness and multiplied by 100 (thickness of change rate). In addition to this, heel fat pad flexibility evaluation consisted of measuring using the softness sensor Softgram. Multiple regression analysis showed that weight and age were predictors of non-pressure thickness. On the other hand, pressure thickness was weight was a predictor of pressure thickness. In the relationship between heel fat pad flexibility and demographic data, the Softgram measurements showed a significantly fair correlation with age and significantly moderate correlations with height and weight. Multiple regression analysis further showed that body weight was a predictor of Softgram measurements. This results suggest that heel fat pad thickness and flexibility in elementary and junior high school students became thicker and stiffer, respectively, with increasing age, height and weight. Notably, both thickness and flexibility were particularly related to body weight.
为了弄清导致年轻人脚跟疼痛的因素,本研究调查了日本小学生和初中生的脚跟厚度和柔韧性与身体人口统计学的关系。共有69只高跟鞋参与了这项研究。测量项目为年龄、身高、体重、罗勒指数、足跟脂肪垫厚度和柔韧性。使用超声探头和S - gram (Shinko Denshi co.,ltd)测量鞋跟脂肪垫的厚度和柔韧性。足跟脂肪垫厚度测量是指从皮肤到跟骨的距离,采用超声探头在测量点上不施加压力(以下称为“无压厚度”)和手动施加压力(以下称为“压厚度”)测量。鞋跟脂肪垫柔韧性评价方法为:用压力厚度(变化差厚度)减去无压厚度,计算变化差厚度除以无压厚度,再乘以100(变化率厚度)后的值。除此之外,鞋跟脂肪垫的柔韧性评估包括使用柔软度传感器Softgram进行测量。多元回归分析显示,体重和年龄是非压力厚度的预测因子。另一方面,压力厚度是重量是压力厚度的预测因子。在跟脂垫柔韧性与人口统计数据之间的关系中,Softgram测量结果显示与年龄有显著的公平相关性,与身高和体重有显著的中等相关性。多元回归分析进一步表明,体重是Softgram测量的预测因子。结果表明,随着年龄、身高和体重的增加,小学生和初中生脚跟脂肪垫厚度和柔韧性分别变厚、变硬。值得注意的是,厚度和柔韧性都与体重密切相关。
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引用次数: 0
Spontaneous Hemothorax of Tumoral Origin Complicating a Von Recklinghausen's Disease: Report of Two Cases in Cameroon and Litterature Review 肿瘤源性自发性血胸合并Von Recklinghausen病:喀麦隆2例报告并文献复习
Pub Date : 2022-01-01 DOI: 10.26502/fjhs.091
L. E. Mangamba, A. Balkissou, V. T. Essoh, AD Batchom, B. Barche, JP Engbang Ndamba, BH Mbatchou Ngahane
Von Recklinghausen's disease also known as neurofibromatosis type 1 (NF1), is one of the most common genetic diseases. It is responsible of the development of neurofibromas from nerve sheaths and very typical skin lesions. Chest damage according to the literature is rare. Spontaneous hemothorax is a subcategory of hemothorax that involves the accumulation of blood in the pleural space in the absence of trauma or other causes. This clinical entity secondary to vascular involvement is rarely described in the literature.
Von Recklinghausen病也被称为1型神经纤维瘤病(NF1),是最常见的遗传性疾病之一。它是神经鞘神经纤维瘤和非常典型的皮肤病变发展的原因。根据文献,胸部损伤是罕见的。自发性血胸是血胸的一个亚类,在没有外伤或其他原因的情况下,血液在胸膜间隙积聚。这种继发于血管受累的临床实体在文献中很少被描述。
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引用次数: 0
FDA-Approved Excipient N, N-Dimethylacetamide Attenuates Inflammatory Bowel Disease in In Vitro and In Vivo Models. 美国食品药品监督管理局批准的赋形剂N,N-二甲基乙酰胺在体外和体内模型中减轻炎症性肠病。
Pub Date : 2022-01-01 Epub Date: 2022-08-26 DOI: 10.26502/fjhs.076
Jagadish B Koya, Tong Shen, Geming Lu, Alex Gauthier, Lin Mantell, Charles R Ashby, Sandra E Reznik

Inflammatory bowel disease (IBD) affects almost 7 million people worldwide and is increasing in incidence. While the precise pathogenesis of IBD remains unknown, the production of inflammatory cytokines and chemokines play a central role. We have previously found that N, N-dimethylacetamide (DMA), a widely used non-toxic drug excipient, suppresses cytokine and chemokine secretion in vitro and prevents inflammation-induced preterm birth in vivo. Using sandwich enzyme-linked immunosorbent assays (ELISAs), we tested whether DMA attenuates cytokine and chemokine secretion from LPS- or TNFα-stimulated human intestinal epithelial cells and human monocytes and HMGB1 release from RAW 264.7 cells. To test our hypothesis that the mechanism of DMA's effects in in vitro and in vivo models of IBD is inhibition of the NF-κB pathway, we used western blotting to track levels of the nuclear factor kappa B (NF-κB) inhibitory molecule I kappa B alpha (IκBα) in THP-1 human monocytes in the absence or presence of DMA. Finally, we induced colitis in C57Bl/6 mice with dextran sodium sulfate (DSS) and then tested whether i.p injections of DMA at 2.1 g/kg/day attenuates clinical and histopathologic signs of colitis. DMA attenuated cytokine and chemokine release from human intestinal epithelial cells and human monocytes and HMGB1 release from RAW 264.7 cells. Importantly, DMA prevented degradation of IκBα in THP-1 cells, thereby suggesting one mechanism for DMA's effects. Finally, we show here, for the first time, that DMA attenuates clinical and histologic features of DSS-induced colitis. Based on these data, DMA should be further explored in preclinical and clinical trials for its potential as novel drug therapy for IBD.

炎症性肠病(IBD)影响着全球近700万人,并且发病率正在上升。虽然IBD的确切发病机制尚不清楚,但炎性细胞因子和趋化因子的产生起着核心作用。我们之前发现,N,N-二甲基乙酰胺(DMA)是一种广泛使用的无毒药物赋形剂,在体外抑制细胞因子和趋化因子的分泌,并在体内预防炎症诱导的早产。使用夹心酶联免疫吸附试验(ELISAs),我们测试DMA是否减弱LPS或TNFα刺激的人类肠上皮细胞和人类单核细胞的细胞因子和趋化因子分泌,以及RAW 264.7细胞的HMGB1释放。为了验证DMA在IBD体外和体内模型中的作用机制是抑制NF-κB通路的假设,我们使用蛋白质印迹来跟踪在不存在或存在DMA的情况下THP-1人单核细胞中核因子κB(NF-κB)抑制分子IκBα(IκB a)的水平。最后,我们用右旋糖酐硫酸钠(DSS)诱导C57Bl/6小鼠结肠炎,然后测试2.1 g/kg/天的DMA腹腔注射是否能减轻结肠炎的临床和组织病理学症状。DMA减弱了人肠上皮细胞和人单核细胞的细胞因子和趋化因子释放以及RAW 264.7细胞的HMGB1释放。重要的是,DMA阻止了THP-1细胞中IκBα的降解,从而提示了DMA作用的一种机制。最后,我们在这里首次表明,DMA减轻了DSS诱导的结肠炎的临床和组织学特征。基于这些数据,DMA应在临床前和临床试验中进一步探索其作为IBD新型药物治疗的潜力。
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引用次数: 0
Effectiveness of Topical 100% Trichloroacetic Acid in Treatment of Anogenital Warts in Male Patients 100%三氯乙酸外用治疗男性生殖器疣的疗效观察
Pub Date : 2022-01-01 DOI: 10.26502/fjhs.044
A. Qayum, Mohammad Majid Paracha, F. Sagheer
had recurrence. Hence topical trichloroacetic acid is effective in 82.2% of studied patients. Conclusion: Topical trichloroacetic acid (100%) is an effective treatment of anogenital warts on male external genitalia with complete cure in 82.2% patients at the end of 6 months of treatment.
有复发。因此,外用三氯乙酸对82.2%的研究患者有效。结论:外用三氯乙酸(100%)是治疗男性外生殖器疣的有效方法,治疗6个月后完全治愈率为82.2%。
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引用次数: 3
Predictive Model of COVID-19 Incidence and Socioeconomic Description of Municipalities in Brazil 巴西城市COVID-19发病率预测模型及社会经济描述
Pub Date : 2022-01-01 DOI: 10.26502/fjhs.049
Mohammad Majid Paracha, Abdul Qayum khan, F. Sagheer, Hina Zahoor
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引用次数: 0
Factors Influencing Institutional Delivery: An Observational Study 影响制度交付的因素:一项观察性研究
Pub Date : 2022-01-01 DOI: 10.26502/fjhs.083
B. R
Institutional delivery refers to the delivery that has taken place in a well-equipped medical centre having skilled delivery assistance. This study was designed to identify the factors that influence delivery in institution. This observational study was conducted at the Department of Maternal and Child Health, National Institute of Preventive and Social Medicine (NIPSOM), Dhaka, Bangladesh. A total of 159 case samples were included following selection criteria. Data regarding socio-demographic characteristics, detailed antenatal history and different factors of institutional delivery were collected accordingly. All data were collected by face to face interview. The mean±SD age of the study subjects was 28.4±7.2 years and ranged was 18-38 years. It was observed that, majority (78.7%) of the respondents was at 20-30 years age range and maximum (56.6%) was house wife. Most (37.7%) of them had secondary level education. Their husband (40.3%) and mother in low (40.3%) were equally predominant as decision maker of the family. Majority (61.6%) of the respondents was came from lower economic class and most (63.5%) of them was living in a nuclear family. Different socio-economic factors like- mother's education, family income, occupation, family types, religious believe, place of residence, access to health information, and several antenatal complications were found to be influential for institutional delivery. This study concluded that antenatal complications, different socio-economic factors and access to health information influencing the utilization of maternal health services and institutional delivery.
机构分娩是指在设备完善的医疗中心进行的分娩,该中心有熟练的分娩协助。本研究旨在找出影响机构内交付的因素。这项观察性研究是在孟加拉国达卡国家预防和社会医学研究所(NIPSOM)妇幼保健部进行的。按照选择标准共纳入159例病例样本。据此收集了有关社会人口统计学特征、详细的产前史和机构分娩的不同因素的数据。所有数据均采用面对面访谈的方式收集。研究对象的平均±SD年龄为28.4±7.2岁,年龄范围为18-38岁。调查发现,年龄介乎20至30岁的受访者占多数(78.7%),家庭主妇占最多(56.6%)。其中大多数(37.7%)受过中等教育。她们的丈夫(40.3%)和母亲(40.3%)作为家庭的决策者同样占主导地位。大多数(61.6%)受访者来自较低的经济阶层,其中大多数(63.5%)生活在核心家庭中。不同的社会经济因素,如母亲的教育程度、家庭收入、职业、家庭类型、宗教信仰、居住地、获得保健信息的机会和一些产前并发症,对机构分娩有影响。这项研究的结论是,产前并发症、不同的社会经济因素和获得保健信息的机会影响孕产妇保健服务的利用和机构交付。
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引用次数: 1
期刊
Fortune journal of health sciences
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