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Characterization of Ag/AgCl Dry Electrodes for Wearable Electrophysiological Sensing Ag/AgCl干式可穿戴电生理传感电极的表征
Pub Date : 2022-01-06 DOI: 10.3389/felec.2021.700363
Min Suk Lee, Akshay Paul, Yuchen Xu, W. Hairston, G. Cauwenberghs
With the rising need for on-body biometric sensing, the development of wearable electrophysiological sensors has been faster than ever. Surface electrodes placed on the skin need to be robust in order to measure biopotentials from the body reliably and comfortable for extended wearability. The electrical stability of nonpolarizable silver/silver chloride (Ag/AgCl) and its low-cost, commercial production have made these electrodes ubiquitous health sensors in the clinical environment, where wet gels and long wires are accommodated by patient immobility. However, smaller, dry electrodes with wireless acquisition are essential for truly wearable, continuous health sensing. Currently, techniques for the robust fabrication of custom Ag/AgCl electrodes are lacking. Here, we present three methods for the fabrication of Ag/AgCl electrodes: oxidizing Ag in a chlorine solution, electroplating Ag, and curing Ag/AgCl ink. Each of these methods is then used to create three different electrode shapes for wearable application. Bench-top and on-body evaluation of the electrode techniques was achieved by electrochemical impedance spectroscopy (EIS), calculation of variance in electrocardiogram (ECG) measurements, and analysis of auditory steady-state response (ASSR) measurement. Microstructures produced on the electrode by each fabrication technique were also investigated with scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). The custom Ag/AgCl electrodes were found to be efficient in comparison with standard, commercial Ag/AgCl wet electrodes across all three of our presented techniques, with Ag/AgCl ink shown to be the better out of the three in bench-top and biometric recordings.
随着对人体生物特征传感的需求不断增加,可穿戴电生理传感器的发展速度比以往任何时候都快。放置在皮肤上的表面电极需要坚固耐用,以便可靠和舒适地测量来自身体的生物电势,以延长可穿戴性。非极化银/氯化银(Ag/AgCl)的电稳定性及其低成本的商业化生产使得这些电极在临床环境中无处不在,在临床环境中,湿凝胶和长导线被病人固定住。然而,具有无线采集功能的更小的干电极对于真正可穿戴的连续健康传感至关重要。目前,缺乏可靠的定制Ag/AgCl电极制造技术。在这里,我们提出了三种制备Ag/AgCl电极的方法:在氯溶液中氧化Ag、电镀Ag和固化Ag/AgCl油墨。然后,这些方法中的每一种都用于创建三种不同形状的电极,用于可穿戴应用。通过电化学阻抗谱(EIS)、心电图(ECG)测量方差计算和听觉稳态响应(ASSR)测量分析,实现了电极技术的台架和身体评估。用扫描电子显微镜(SEM)和能量色散x射线能谱(EDX)研究了每种制造技术在电极上产生的微观结构。在我们提出的所有三种技术中,与标准的商业Ag/AgCl湿电极相比,发现定制的Ag/AgCl电极是有效的,Ag/AgCl墨水在台式和生物识别记录中表现得更好。
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引用次数: 6
The Influence of Climate Conditions and On-Skin Positioning on InGaZnO Thin-Film Transistor Performance 气候条件和表皮定位对InGaZnO薄膜晶体管性能的影响
Pub Date : 2022-01-06 DOI: 10.3389/felec.2021.786601
Federica Catania, Hugo de Souza Oliveira, M. C. Costa Angeli, M. Ciocca, S. Pané, N. Münzenrieder, G. Cantarella
Thin-film transistors (TFTs) based on amorphous indium-gallium-zinc-oxide (a-IGZO) have proved promising features for flexible and lightweight electronics. To achieve technological maturity for commercial and industrial applications, their stability under extreme environmental conditions is highly required. The combined effects of temperature (T) from −30.0°C to 50.0°C and relative humidity (RH) stress from 0 to 95% on a-IGZO TFT is presented. The TFT performances and the parameters variation were analysed in two different experiments. First, the TFT response was extracted while undergoing the most extreme climate conditions on Earth, ranging from the African Desert (50.0°C, 22%) to Antarctic (−30.0°C, 0%). Afterwards, the device functionality was demonstrated in three parts of the human body (forehand, arm and foot) at low (35%), medium (60%) and high (95%) relative humidity for on-skin and wearable applications. The sensitivity to T/RH variations suggests the suitability of these TFTs as sensing element for epidermal electronics and artificial skin.
基于非晶铟镓锌氧化物(a-IGZO)的薄膜晶体管(TFT)已被证明具有柔性和轻型电子产品的良好特性。为了实现商业和工业应用的技术成熟,它们在极端环境条件下的稳定性是非常必要的。介绍了−30.0°C至50.0°C的温度(T)和0至95%的相对湿度(RH)应力对a-IGZO TFT的综合影响。在两个不同的实验中分析了TFT的性能和参数的变化。首先,TFT响应是在经历地球上最极端的气候条件时提取的,从非洲沙漠(50.0°C,22%)到南极(−30.0°C(0%))。之后,在人体的三个部位(正手、手臂和脚),在低(35%)、中(60%)和高(95%)相对湿度下,展示了该设备的功能,用于皮肤和可穿戴应用。对T/RH变化的敏感性表明这些TFT适合作为表皮电子和人造皮肤的传感元件。
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引用次数: 3
System Performance and User Feedback Regarding Wearable Bioimpedance System for Multi-Site Knee Tissue Monitoring: Free-Living Pilot Study With Healthy Adults. 关于可穿戴生物阻抗系统用于多点膝关节组织监测的系统性能和用户反馈:健康成人的自由生活试点研究。
Pub Date : 2022-01-01 DOI: 10.3389/felec.2022.824981
Shelby Critcher, Todd J Freeborn

Knee-focused wearable devices have the potential to support personalized rehabilitation therapies by monitoring localized tissue alterations related to activities that reduce functional symptoms and pain. However, supporting these applications requires reported data to be reliable and accurate which can be challenging in the unsupervised free-living conditions that wearable devices are deployed. This pilot study has assessed a knee-focused wearable sensor system to quantify 1) system performance (operation, rates of data artifacts, environment impacts) to estimate realistic targets for reliable data with this system and 2) user experiences (comfort, fit, usability) to help inform future designs to increase usability and adoption of knee-focused wearables. Study data was collected from five healthy adult participants over 2 days, with 84.5 and 35.9% of artifact free data for longitudinal and transverse electrode configurations. Small to moderate positive correlations were also identified between changes in resistance, temperature, and humidity with respect to acceleration to highlight how this system can be used to explore relationships between knee tissues and environmental/activity context.

针对膝关节的可穿戴设备通过监测与活动相关的局部组织改变,从而减轻功能症状和疼痛,具有支持个性化康复治疗的潜力。然而,支持这些应用程序需要报告的数据可靠和准确,这在部署可穿戴设备的无监督自由生活条件下可能具有挑战性。这项试点研究评估了一个以膝盖为中心的可穿戴传感器系统,以量化1)系统性能(操作、数据伪像率、环境影响),以估计该系统可靠数据的现实目标;2)用户体验(舒适度、适合度、可用性),以帮助为未来的设计提供信息,以提高以膝盖为中心的可穿戴设备的可用性和采用。研究数据来自5名健康成人参与者,收集时间超过2天,其中纵向和横向电极配置的无伪影数据分别为84.5%和35.9%。还发现阻力、温度和湿度的变化与加速度之间存在小到中等的正相关关系,以突出该系统如何用于探索膝关节组织与环境/活动背景之间的关系。
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引用次数: 7
Bio-Compatible Sensor for Middle Ear Pressure Monitoring on a Bio-Degradable Substrate 基于生物降解基质的生物相容性中耳压力监测传感器
Pub Date : 2021-12-24 DOI: 10.3389/felec.2021.802356
Klara Mosshammer, Theresa Lüdke, Sarah Spitzner, Daniel Firzlaff, K. Harre, H. Kleemann, M. Neudert, T. Zahnert, K. Leo
Hypotension in the middle ear can cause serious diseases and hearing disorders. Until now, pressure in the middle ear is measured indirectly by using the impedance of the tympanic membrane (tympanometry). Direct methods are just described in scientific studies and would be harmful in clinical routine. Here, we demonstrate a bio-compatible pressure sensor, which can resolve pressure changes in the range of −7.5 kPa up to +7.5 kPa, and due to its compact design (area of 2 × 4 mm2), can be directly implanted in the human middle ear. Furthermore, the read-out of the pressure sensor can be conveniently done using wireless data communication technologies employing a plate capacitor with an elastic dielectric for pressure monitoring and a planar coil. Thus, our sensor allows for direct pressure measurements in the middle ear, avoiding additional surgeries after device implantation.
中耳低血压可导致严重的疾病和听力障碍。到目前为止,中耳的压力是通过使用鼓膜的阻抗间接测量的(鼓膜测量法)。直接的方法只是在科学研究中描述的,在临床常规中是有害的。在这里,我们展示了一种生物兼容的压力传感器,它可以解决−7.5 kPa至+7.5范围内的压力变化 kPa,由于其紧凑的设计(面积为2×4mm2),可以直接植入人的中耳。此外,可以使用无线数据通信技术方便地进行压力传感器的读出,该无线数据通信系统采用具有用于压力监测的弹性电介质的平板电容器和平面线圈。因此,我们的传感器允许直接测量中耳中的压力,避免了设备植入后的额外手术。
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引用次数: 0
A Multi-Frequency Focused Impedance Measurement System Based on Analogue Synchronous Peak Detection 基于模拟同步峰值检测的多频聚焦阻抗测量系统
Pub Date : 2021-12-10 DOI: 10.3389/felec.2021.791016
M. A. Kadir, Adrian J. Wilson, K. Siddique-e Rabbani
Monitoring of anatomical structures and physiological processes by electrical impedance has attracted scientists as it is noninvasive, nonionizing and the instrumentation is relatively simple. Focused Impedance Method (FIM) is attractive in this context, as it has enhanced sensitivity at the central region directly beneath the electrode configuration minimizing contribution from neighboring regions. FIM essentially adds or averages two concentric and orthogonal combinations of conventional Tetrapolar Impedance Measurements (TPIM) and has three versions with 4, 6, and 8 electrodes. This paper describes the design and testing of a multi-frequency FIM (MFFIM) system capable of measuring all three versions of FIM at 8 frequencies in the range 10 kHz—1 MHz. A microcontroller based multi-frequency signal generator and a balanced Howland current source with high output impedance (476 kΩ at 10 kHz and 58.3 kΩ at 1 MHz) were implemented for driving currents into biological tissues with an error <1%. The measurements were carried out at each frequency sequentially. The peak values of the amplified voltage signals were measured using a novel analogue synchronous peak detection technique from which the transfer impedances were obtained. The developed system was tested using TPIM measurements on a passive RC Cole network placed between two RC networks, the latter representing skin-electrode contact impedances. Overall accuracy of the measurement was very good (error <4% at all frequencies except 1 MHz, with error 6%) and the resolution was 0.1 Ω. The designed MFFIM system had a sampling rate of >45 frames per second which was deemed adequate for noninvasive real-time impedance measurements on biological tissues.
电阻抗监测解剖结构和生理过程因其无创、非电离和仪器相对简单而吸引了科学家。聚焦阻抗法(FIM)在这种情况下很有吸引力,因为它在电极结构正下方的中心区域增强了灵敏度,最大限度地减少了邻近区域的影响。FIM基本上是将传统四极阻抗测量(TPIM)的两个同心和正交组合相加或平均,并有4、6和8个电极的三种版本。本文描述了一个多频FIM (MFFIM)系统的设计和测试,该系统能够在10 kHz-1 MHz范围内的8个频率测量所有三个版本的FIM。基于微控制器的多频信号发生器和具有高输出阻抗的平衡Howland电流源(10khz时为476 kΩ, 1mhz时为58.3 kΩ)用于驱动电流进入生物组织,误差为每秒45帧,被认为足以用于生物组织的非侵入性实时阻抗测量。
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引用次数: 3
Mechanical Stress Stability of Flexible Amorphous Zinc Tin Oxide Thin-Film Transistors 柔性非晶氧化锌锡薄膜晶体管的机械应力稳定性
Pub Date : 2021-12-09 DOI: 10.3389/felec.2021.797308
Oliver Lahr, Max Steudel, H. von Wenckstern, M. Grundmann
Due to their low-temperature processing capability and ionic bonding configuration, amorphous oxide semiconductors (AOS) are well suited for applications within future mechanically flexible electronics. Over the past couple of years, amorphous zinc tin oxide (ZTO) has been proposed as indium and gallium-free and thus more sustainable alternative to the widely deployed indium gallium zinc oxide (IGZO). The present study specifically focuses on the strain-dependence of elastic and electrical properties of amorphous zinc tin oxide thin-films sputtered at room temperature. Corresponding MESFETs have been compared regarding their operation stability under mechanical bending for radii ranging from 5 to 2 mm. Force-spectroscopic measurements yield a plastic deformation of ZTO as soon as the bending-induced strain exceeds 0.83 %. However, the electrical properties of ZTO determined by Hall effect measurements at room temperature are demonstrated to be unaffected by residual compressive and tensile strain up to 1.24 %. Even for the maximum investigated tensile strain of 1.26 %, the MESFETs exhibit a reasonably consistent performance in terms of current on/off ratios between six and seven orders of magnitude, a subthreshold swing around 350 mV/dec and a field-effect mobility as high as 7.5 cm2V−1s−1. Upon gradually subjecting the transistors to higher tensile strain, the channel conductivity steadily improves and consequently, the field-effect mobility increases by nearly 80 % while bending the devices around a radius of 2 mm. Further, a reversible threshold voltage shift of about −150 mV with increasing strain is observable. Overall, amorphous ZTO provides reasonably stable electrical properties and device performance for bending-induced tensile strain up to at least 1.26 % and thus represent a promising material of choice considering novel bendable and transparent electronics.
由于其低温加工能力和离子键合配置,非晶氧化物半导体(AOS)非常适合未来机械柔性电子产品的应用。在过去的几年里,非晶氧化锌锡(ZTO)被认为是不含铟和镓的,因此是广泛部署的氧化铟镓锌(IGZO)的更可持续的替代品。本研究特别关注室温溅射非晶氧化锌锡薄膜的弹性和电学性能的应变依赖性。比较了相应的MESFET在半径为5至2 mm的机械弯曲下的工作稳定性。一旦弯曲引起的应变超过0.83,力谱测量就会产生ZTO的塑性变形 %. 然而,在室温下通过霍尔效应测量确定的ZTO的电性能被证明不受高达1.24的残余压缩和拉伸应变的影响 %. 即使研究的最大拉伸应变为1.26 %, MESFET在电流导通/截止比方面表现出相当一致的性能,在6到7个数量级之间,亚阈值摆动约为350 mV/dec,场效应迁移率高达7.5 cm2V−1s−1。当晶体管逐渐受到更高的拉伸应变时,沟道导电性稳步提高,因此场效应迁移率增加了近80 % 同时将器件弯曲半径为2 mm。此外,随着应变的增加,可以观察到约−150 mV的可逆阈值电压偏移。总的来说,非晶ZTO为高达至少1.26的弯曲诱导拉伸应变提供了相当稳定的电性能和器件性能 % 因此代表了考虑到新型可弯曲和透明电子器件的有前途的选择材料。
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引用次数: 0
Review of the Multi-Input Single-Inductor Multi-Output Energy Harvesting Interface Applied in Wearable Electronics 多输入单电感多输出能量采集接口在可穿戴电子器件中的应用综述
Pub Date : 2021-12-06 DOI: 10.3389/felec.2021.793780
Zhuo Gao, Shiwei Wang, Yongfu Li, Mingyi Chen
Along with the industrialization and popularization of the wearable electronics, an increasing number of the wireless sensor nodes (WSNs) are deployed. Nevertheless, the conventional battery-based power supply system has no longer satisfied the requirement of large-scale WSNs in terms of battery life, which emerges the energy harvesting (EH) technique. In order to combine various of energy sources and drive multi-loads, the multi-input single-inductor multi-output (MISIMO) EH interface applied to wearable electronics is spotlighted. In this mini-review article, the solutions for improving power conversion efficiency (PCE) and output quality in MISIMO EH interface are summarized. Furthermore, the future trends of MISIMO EH interface are also presented.
随着可穿戴电子产品的工业化和普及,越来越多的无线传感器节点(wsn)被部署。然而,传统的电池供电系统在电池寿命方面已经不能满足大规模无线传感器网络的要求,因此出现了能量收集(EH)技术。为了结合多种能量源和驱动多负载,应用于可穿戴电子产品的多输入单电感多输出(MISIMO) EH接口备受关注。本文综述了提高MISIMO EH接口功率转换效率和输出质量的解决方案。展望了MISIMO EH接口的发展趋势。
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引用次数: 2
Substrate Treatment Evaluation and Their Impact on Printing Results for Wearable Electronics 基板处理评价及其对可穿戴电子产品印刷效果的影响
Pub Date : 2021-11-16 DOI: 10.3389/felec.2021.777434
Saleem Khan, Shawkat Ali, Arshad Khan, Bo Wang, T. Al-Ansari, A. Bermak
This paper presents a comparative study on the treatment techniques for flexible polymeric substrates and their impact on the printing results. Substrate treatments are central to optimization of the printing processes and a strict set of requirements are needed to achieve uniform and acceptable printing results. Therefore, this research is highlighting the most significant treatment methods used for fine-tuning the surface properties of different polymeric substrates. Besides the two commonly used treatment techniques of oxygen plasma and ultraviolet ozone, a new method of using surface cleaning liquid is applied for rapid treatment of polymeric substrates. Comparative study is carried out on the basis of cleaning steps required for substrate preparation, processing, robustness as well as on the final printed results on the substrates. All the three treatment techniques with similar processing protocol are applied on a single type of polyimide (PI) substrate. To further validate the applicability and manufacture of practical devices, the liquid cleaning method is also applied on Polyethylene terephthalate substrates for making proof-of-concept wearable temperature sensor. From the study it is concluded that the liquid surface cleaning method is advantageous in terms of easy processing, robustness and producing uniform printing results on diverse polymeric substrates.
本文比较研究了柔性聚合物基材的处理技术及其对印刷效果的影响。基材处理是优化印刷过程的核心,需要一套严格的要求来实现统一和可接受的印刷结果。因此,本研究突出了用于微调不同聚合物衬底表面性能的最重要的处理方法。除了氧等离子体和紫外臭氧两种常用的处理技术外,还提出了一种使用表面清洗液进行聚合物基材快速处理的新方法。根据基材制备、加工、坚固性所需的清洗步骤以及基材上的最终印刷结果进行比较研究。这三种具有相似处理方案的处理技术都应用于单一类型的聚酰亚胺(PI)衬底上。为了进一步验证实际设备的适用性和制造,还将液体清洗方法应用于聚对苯二甲酸乙二醇酯基板上,以制作概念验证的可穿戴温度传感器。研究结果表明,液体表面清洗方法具有易于加工、坚固耐用、在不同聚合物基材上印刷效果均匀等优点。
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引用次数: 1
A Charge Balanced Neural Stimulator Silicon Chip for Human-Machine Interface 一种用于人机界面的电荷平衡神经刺激芯片
Pub Date : 2021-10-22 DOI: 10.3389/felec.2021.773812
Xu Liu, Juzhe Li, Wei Mao, Zhuangguang Chen, Zhijie Chen, Peiyuan Wan, Hao Yu
This paper proposes a neural stimulator silicon chip design with an improved charge balancing technology. The proposed neural stimulation integrated circuit (IC) uses two charge balancing modules including synchronous charge detection module and short-time pulse insertion module. The synchronous charge detection module is designed based on a current splitter with ultra-small output current and an integrator circuit for neural stimulation pulse width control, which greatly reduces the residual charge remained on the electrode-tissue interface. The short-time pulse insertion module is designed based on the electrode voltage detection and compensation current control, which further reduces the accumulated residual charge and keeps the electrode voltage within a safety range of ±25 mV during multiple stimulation cycles. Finally, this neural stimulator is implemented in TSMC 0.18-μm CMOS process technology, and the chip function is tested and verified in both experiments with the electrode-tissue RC model and the PBS saline solution environment. The measurement result shows the neural stimulator chip achieves improved charge balancing with the residual charge smaller than 0.95 nC, which is the lowest compared to the traditional neural stimulator chips.
本文提出了一种采用改进的电荷平衡技术的神经刺激器硅片设计。所提出的神经刺激集成电路(IC)使用两个电荷平衡模块,包括同步电荷检测模块和短时脉冲插入模块。同步电荷检测模块是基于具有超小输出电流的分流器和用于神经刺激脉宽控制的积分电路设计的,这大大减少了残留在电极-组织界面上的残余电荷。短时脉冲插入模块是基于电极电压检测和补偿电流控制设计的,在多个刺激周期内,进一步减少了累积的残余电荷,并将电极电压保持在±25mV的安全范围内。最后,该神经刺激器在台积电0.18-μm CMOS工艺技术中实现,并在电极-组织RC模型和PBS盐水环境下对芯片功能进行了测试和验证。测量结果表明,该神经刺激器芯片实现了改进的电荷平衡,剩余电荷小于0.95nC,与传统神经刺激剂芯片相比是最低的。
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引用次数: 0
Quasi-Zero Dimensional Halide Perovskite Derivates: Synthesis, Status, and Opportunity 准零维卤化物钙钛矿衍生物:合成、现状和机遇
Pub Date : 2021-10-11 DOI: 10.3389/felec.2021.758603
V. Trifiletti, Ceyla Asker, G. Tseberlidis, S. Riva, K. Zhao, Weidong Tang, S. Binetti, O. Fenwick
In recent decades, many technological advances have been enabled by nanoscale phenomena, giving rise to the field of nanotechnology. In particular, unique optical and electronic phenomena occur on length scales less than 10 nanometres, which enable novel applications. Halide perovskites have been the focus of intense research on their optoelectronic properties and have demonstrated impressive performance in photovoltaic devices and later in other optoelectronic technologies, such as lasers and light-emitting diodes. The most studied crystalline form is the three-dimensional one, but, recently, the exploration of the low-dimensional derivatives has enabled new sub-classes of halide perovskite materials to emerge with distinct properties. In these materials, low-dimensional metal halide structures responsible for the electronic properties are separated and partially insulated from one another by the (typically organic) cations. Confinement occurs on a crystal lattice level, enabling bulk or thin-film materials that retain a degree of low-dimensional character. In particular, quasi-zero dimensional perovskite derivatives are proving to have distinct electronic, absorption, and photoluminescence properties. They are being explored for various technologies beyond photovoltaics (e.g. thermoelectrics, lasing, photodetectors, memristors, capacitors, LEDs). This review brings together the recent literature on these zero-dimensional materials in an interdisciplinary way that can spur applications for these compounds. The synthesis methods, the electrical, optical, and chemical properties, the advances in applications, and the challenges that need to be overcome as candidates for future electronic devices have been covered.
近几十年来,许多技术进步都是由纳米级现象实现的,从而产生了纳米技术领域。特别是,独特的光学和电子现象发生在小于10纳米的长度尺度上,这使得新的应用成为可能。卤化物钙钛矿一直是其光电性能研究的焦点,并在光伏器件和后来的其他光电技术(如激光器和发光二极管)中展示了令人印象深刻的性能。研究最多的晶体形式是三维的,但是,最近,对低维衍生物的探索使得新的子类卤化物钙钛矿材料具有不同的性能。在这些材料中,负责电子性能的低维金属卤化物结构被(通常是有机的)阳离子分开并相互部分绝缘。约束发生在晶格水平上,使块状或薄膜材料保持一定程度的低维特性。特别是,准零维钙钛矿衍生物被证明具有独特的电子、吸收和光致发光性质。他们正在探索光电以外的各种技术(如热电、激光、光电探测器、忆阻器、电容器、led)。本综述以跨学科的方式汇集了这些零维材料的最新文献,可以促进这些化合物的应用。本文涵盖了合成方法、电学、光学和化学性质、应用进展以及作为未来电子器件候选者需要克服的挑战。
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引用次数: 4
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Frontiers in electronics
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