IJID regions最新文献

{"title":"Factors predictive of epidemic waves of COVID-19 in Africa during the first 2 years of the pandemic","authors":"Patient Wimba ,&nbsp;Aboubacar Diallo ,&nbsp;Amna Klich ,&nbsp;Léon Tshilolo ,&nbsp;Jean Iwaz ,&nbsp;Jean François Étard ,&nbsp;Philippe Vanhems ,&nbsp;René Ecochard ,&nbsp;Muriel Rabilloud","doi":"10.1016/j.ijregi.2025.100574","DOIUrl":"10.1016/j.ijregi.2025.100574","url":null,"abstract":"<div><h3>Objectives</h3><div>The objective was to study the epidemic wave curves, according to the characteristics of the countries, to identify the differences and the predictive factors of evolution.</div></div><div><h3>Methods</h3><div>We have carried out modeling of the COVID-19 epidemic data from validated databases for 53 African countries.</div></div><div><h3>Results</h3><div>All countries recorded at least four waves. The duration of the waves had decreased over time (<em>P</em> &lt;0.001) and extended with the rainy season (<em>P</em> = 0.03). The incidence rates were higher for countries with the best development indicators (<em>P</em> &lt;0.001). Positive spatial autocorrelation was significant for all wave characteristics, except for relative amplitude at the end of the wave. The time-adjusted multivariate analysis identified seasons for duration (<em>P</em> = 0.017) and human development index for peak incidence rate (<em>P</em> &lt;0.001) and relative amplitude at the end of the wave (<em>P</em> = 0.041) as predictors of wave characteristics.</div></div><div><h3>Conclusions</h3><div>The duration of the waves was influenced by the seasons and the study periods, the incidences by the economic development, and health indicators. The appearance of new variants seemed associated with the start of the waves. None of the factors studied is associated with an inflection and a decrease in the curve.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100574"},"PeriodicalIF":1.5,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV incidence and adherence after pre-exposure prophylaxis initiation in key populations in Indonesia: Findings from a real-world pilot program 2021-2023","authors":"Nadia Hanum ,&nbsp;Miasari Handayani ,&nbsp;Armina Padmasawitri ,&nbsp;Zulfan Zazuli ,&nbsp;Kusnandar Anggadiredja ,&nbsp;Mawar N. Pohan ,&nbsp;Tarinanda A. Putri ,&nbsp;Fani F. Rakhmat ,&nbsp;Dwi S. Anggiani ,&nbsp;Nurhalina Afriana ,&nbsp;Endang Lukitosari ,&nbsp;Bagus R. Prabowo ,&nbsp;Rudi Wisaksana","doi":"10.1016/j.ijregi.2025.100573","DOIUrl":"10.1016/j.ijregi.2025.100573","url":null,"abstract":"<div><h3>Objectives</h3><div>To provide important data for the national rollout, Indonesia launched a pre-exposure prophylaxis (PrEP) pilot program. In this study, we determined the HIV incidence and adherence among key populations, PrEP initiation, sexually transmitted infection incidence, and changes in sexual behaviors.</div></div><div><h3>Methods</h3><div>The Indonesian PrEP pilot program (December 2021 to December 2023, rolled out in 21 districts in 10 provinces) was a longitudinal, non-randomized implementation study among men who have sex with men, female sex workers, transgender women, people who inject drugs, and serodiscordant partners of people with HIV. Eligible participants were offered same-day oral PrEP and completed the baseline, 1-monthly, and 3-monthly follow-up visits.</div></div><div><h3>Results</h3><div>A total of 9124 individuals initiated PrEP between December 2021 and December 2023; 4220 had at least one follow-up visit. Of the 4220, 31 seroconverted over 2817.5 person-years; overall incidence rate (IR) 1.10 (95% confidence interval 0.75-1.56) per 100 person-years. All seroconversions occurred during poor adherence or PrEP discontinuation (IR 7.8; 5.34-11.16 vs 0; 0-0.4 for adequate adherence). Event-driven PrEP users showed poorer adherence than daily PrEP users (<em>P &lt;</em>0.001). In men who have sex with men, HIV incidence was higher in those who lived outside Java and Bali (adjusted IR ratio 5.56; 1.68-18.38, <em>P</em> = 0.005).</div></div><div><h3>Conclusion</h3><div>Insufficient adherence leads to decreased efficacy of PrEP. Improving adherence and access to PrEP is a public health priority in Indonesia.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100573"},"PeriodicalIF":1.5,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143313003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The vaccination acceptance, confidence, and conviction on influenza in the Middle East, Eurasia, and Africa among healthcare providers (VACCIMENA-HCP) project 2023: Determinants of vaccination behavior","authors":"Mine Durusu Tanriover ,&nbsp;Gaelle Vallee-Tourangeau ,&nbsp;Valentin A. Kokorin ,&nbsp;Vera N. Larina ,&nbsp;Mouna Maamar ,&nbsp;Hicham Harmouche ,&nbsp;Oğuz Abdullah Uyaroğlu ,&nbsp;Dilan Yağmur Kutlay ,&nbsp;Jalila Ben Khelil ,&nbsp;Abdul-Azeez A. Anjorin ,&nbsp;Muhammad Suleman Rana ,&nbsp;Jabrayil Jabrayilov ,&nbsp;Fatima Al Slail ,&nbsp;Dalal Al Kathiry ,&nbsp;Hasina Al Harthi ,&nbsp;Ramy Mohamed Ghazy ,&nbsp;Milad Gahwagi ,&nbsp;Alireza Mafi ,&nbsp;Parvaiz Koul ,&nbsp;Salah Al Awaidy","doi":"10.1016/j.ijregi.2025.100572","DOIUrl":"10.1016/j.ijregi.2025.100572","url":null,"abstract":"<div><h3>Objectives</h3><div>Annual vaccination is the most effective way to prevent and control the health and economic burden of seasonal influenza. Healthcare providers (HCPs) play a crucial role in vaccine acceptance and patient advocacy. This study aimed to explore the barriers and drivers of HCPs’ vaccine acceptance and advocacy for the vaccination of their patients in countries in the Middle East, Eurasia, and Africa.</div></div><div><h3>Methods</h3><div>Healthcare providers from 10 countries (Azerbaijan, Egypt, Libya, Morocco, Nigeria, Pakistan, Russia, Saudi Arabia, Tunisia, and Türkiye) were surveyed using opportunity sampling between 20^th December 2022, and 1^st March 2023. The previously developed motors of influenza vaccination acceptance (MoVac-Flu) and engagement with vaccination advocacy (MovAd) scales were used.</div></div><div><h3>Results</h3><div>In the final sample of 721 responses, Russia was the leading country, enrolling 37% of all respondents. Sentiment cluster profiles were labeled as “engaged” or “hesitant” and “confident” or “diffident.” Overall, 28% demonstrated hesitancy and 30.5% demonstrated diffident sentiments toward self-vaccination behavior. HCPs exhibited very low rates of routine vaccination and infrequent advocacy of seasonal influenza vaccinations. In contrast, those who felt engaged with influenza vaccination were more likely to be vaccinated themselves and found it easier to incorporate influenza vaccination in their practice. Those who felt engaged in influenza vaccination also felt more confident in advocating for it than those who felt hesitant. The evidence suggests that the strength of the relationship between engagement and confidence varies across countries.</div></div><div><h3>Conclusions</h3><div>This study provides insights into the behavioral patterns of HCPs regarding their own influenza vaccination and advocacy for patient vaccination. Cluster membership was a strong predictor of vaccination behaviors and attitudes, although regional differences were observed. For hesitant and diffident HCPs, tailored strategies to increase awareness and empower them regarding vaccines and vaccine-preventable diseases are crucial.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100572"},"PeriodicalIF":1.5,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological features of scrub typhus and molecular characteristics of Orientia tsutsugamushi in north-central Bangladesh","authors":"Sultana Shabnam Nila ,&nbsp;Meiji Soe Aung ,&nbsp;Nazia Haque ,&nbsp;Shyamal Kumar Paul ,&nbsp;Syeda Anjuman Nasreen ,&nbsp;Sangjukta Roy ,&nbsp;Salma Ahmed ,&nbsp;Jobyda Khanam ,&nbsp;Mohammad Abdul Awal Bin Sayeed ,&nbsp;Shashwata Paul ,&nbsp;Noriko Urushibara ,&nbsp;Mitsuyo Kawaguchiya ,&nbsp;Nobuhide Ohashi ,&nbsp;Nobumichi Kobayashi","doi":"10.1016/j.ijregi.2025.100571","DOIUrl":"10.1016/j.ijregi.2025.100571","url":null,"abstract":"<div><h3>Objectives</h3><div>Scrub typhus is an acute febrile disease caused by <em>Orientia tsutsugamushi</em> transmitted through trombiculid mites. This study aimed to clarify the prevalence and clinical features of scrub typhus and the molecular epidemiological characteristics of <em>O. tsutsugamushi</em> in north-central Bangladesh.</div></div><div><h3>Methods</h3><div>Blood samples were collected from patients with febrile illness at a single medical institution over a 1-year period. Using DNA samples extracted from blood, <em>O. tsutsugamushi</em> was identified by nested polymerase chain reaction targeting the outer membrane protein (47-kDa) gene. Phylogenetic analysis was performed based on the genes encoding a 56-kDa type-specific antigen (TSA) and <em>trxA</em>, along with genotyping by multilocus sequence typing (MLST).</div></div><div><h3>Results</h3><div>Among the 744 patients, 72 (9.7%) were diagnosed with the scrub typhus and exhibited nausea (93%) and myalgia (75%) more commonly than did non-scrub typhus cases. On the basis of the TSA gene, eight samples were assigned to Karp-related (n = 7; clades 2 and 4b) and Gilliam (n = 1) genotypes. Among the 10 samples, nine sequence types (STs), including eight new types (ST101-ST108) were identified, with three STs grouped into clonal complex 105 (CC105). On the basis of the phylogenetic analysis of <em>trxA</em>, the Bangladeshi samples were differentiated into two clusters.</div></div><div><h3>Conclusions</h3><div>The genetic characteristics of <em>O. tsutsugamushi</em> in Bangladesh revealed a potentially dominant genetic group (Karp-c2 and CC105).</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100571"},"PeriodicalIF":1.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143313002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey on the prevalence of health care–associated infections at the Fann University Hospital in Dakar, Senegal","authors":"Daye Ka ,&nbsp;Emery Yongola Osongo ,&nbsp;Fatoumata Diallo ,&nbsp;Ahmadou Lo ,&nbsp;Bruce Shinga Wembulua ,&nbsp;Catherine Sarr ,&nbsp;Maimouna Sarr ,&nbsp;Mame Diarra Mbaye ,&nbsp;Pape Amath Diagne ,&nbsp;Mamadou Baila Diallo ,&nbsp;Abdou Aziz Fall ,&nbsp;Ndéye Maguette Fall ,&nbsp;EL Hadj Cheikh Ndiaye Sy ,&nbsp;Moussa Seydi","doi":"10.1016/j.ijregi.2025.100569","DOIUrl":"10.1016/j.ijregi.2025.100569","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to determine the prevalence of health care–associated infections (HAIs) at Fann Hospital, describe the profile of patients with HAI, and identify the causative pathogens.</div></div><div><h3>Methods</h3><div>This was a cross-sectional survey of the records of patients hospitalized in eight departments of the Fann University Hospital for a microbiologically confirmed HAI from January 1, 2024 to March 31, 2024. Data were collected using an HAI surveillance form and analyzed using R software version 4.4.0.</div></div><div><h3>Results</h3><div>Over a 3-month period, 62 cases of HAI were recorded out of a total of 1725 patients, giving a hospital attack rate of 3.5%. The median age of the patients was 59 years (interquartile range: 68-47). Males predominated (54.8%). Hospitalized patients came directly from their homes (40.3%) or from other university hospitals (35.5%). Arterial hypertension (29%) and diabetes mellitus (19.3%) were the main comorbidities. A history of previous surgery was found in 8% of the cases. Fever was the most common clinical manifestation (71%), followed by respiratory symptoms (29%). The medical devices used were venous (100%) and urinary catheters (54.5%). The most frequently isolated bacteria were <em>Pseudomonas spp</em> (23.6%), <em>Staphylococcus aureus</em> (21.8%), and <em>Escherichia coli</em> (21.8%). In terms of the resistance phenotype, 43.6% and 21.8% of patients had extended-spectrum β-lactamase–producing Enterobacteriaceae and methicillin-resistant <em>S. aureus</em>, respectively. During hospitalization, 45 patients received nonspecific antibiotic therapy at the time of HAI. Death occurred in 11 patients, representing a fatality rate of 17.7%.</div></div><div><h3>Conclusions</h3><div>The quarterly prevalence of HAIs was high in our hospital. Therefore, it is necessary to investigate the factors associated with their occurrence.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100569"},"PeriodicalIF":1.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143312999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between excess mortality due to COVID-19, full vaccination coverage, smoking, hypertension, and gross domestic product per capita/purchasing power parity across 10 Southeast Asian Countries","authors":"Mu'syadzwinna Binti Midon ,&nbsp;Nlandu Roger Ngatu ,&nbsp;Kanae Kanda ,&nbsp;Tomohiro Hirao ,&nbsp;Nobuyuki Miyatake ,&nbsp;Kenji Wada ,&nbsp;Akira Nishiyama","doi":"10.1016/j.ijregi.2025.100570","DOIUrl":"10.1016/j.ijregi.2025.100570","url":null,"abstract":"<div><h3>Objectives</h3><div>Mass vaccination and cardiometabolic disorders have been reported to influence COVID-19 prognosis and mortality burden. We applied a generalized linear mixed model (GLMM) to explore the associations between COVID-19 mortality, full vaccination coverage, and cardiometabolic health indicators in Southeast Asia (SEAR).</div></div><div><h3>Methods</h3><div>A region-wide ecological analysis of aggregate COVID-19 data from 10 SEAR countries (January 2020 to December 2022) was performed. The databases used were from the John Hopkins University Coronavirus Resource Center and the WHO Health Organization. Excess deaths associated with COVID-19 per 100,000 and case fatality rate were the outcome variables. A GLMM was performed to determine the predictors of COVID-19 mortality, and adjustments were made for sociodemographic variables. The statistical significance level was set at <em>P</em> &lt;0.01 (double-sided).</div></div><div><h3>Results</h3><div>The adjusted GLMM analysis showed that the number of excess deaths due to COVID-19 per 100,000 was strongly and positively associated with age-standardized smoking (coefficient of determination [coeff.] = 9.18 [standard error (SE): 2.15]; <em>P</em> &lt;0.001) and hypertension prevalence (coeff. = 25.98 [SE: 9.15]; <em>P</em> &lt;0.01), whereas it was strongly and negatively associated with the full vaccination coverage rate (coeff. = −5.23 [SE: 1.54]; <em>P</em> &lt;0.01) and gross domestic product per capita/purchasing power parity (coeff. = −102.01 [SE: 18.31]; <em>P</em> &lt;0.001). The COVID-19 case fatality rate was positively associated with the age-standardized prevalence of hypertension (coeff. = 0.30 [SE: 0.16]; <em>P</em> &lt;0.01) and negatively correlated with the full vaccination coverage rate (coeff. = −0.05 [SE: 0.01]; <em>P</em> &lt;0.01) and gross domestic product per capita/purchasing power parity (coeff. = −1.09 (SE: 0.34); p&lt;0.001). The associations observed in the multivariate analysis remained in the stratified analysis by quartile.</div></div><div><h3>Conclusions</h3><div>The study findings suggest that implementing effective public health interventions that would have increased vaccine uptake and improve cardiometabolic health on one hand and initiatives that enhance country-level economy on the other hand would have reduced COVID-19 mortality in the SEAR.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100570"},"PeriodicalIF":1.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint improvement in birth registration on civil status and immunization coverage of infants aged 0-23 months: the added value of community tool use in collaboration between town halls and the health district in Goudomp, Senegal","authors":"Ibrahima Mamby Keita ,&nbsp;Mamadou Couulibaly ,&nbsp;Abdoulaye Diatta ,&nbsp;Samba Ndiaye ,&nbsp;Hameth Satigui Sow ,&nbsp;Oumar Diarra ,&nbsp;Ndeye Sarr ,&nbsp;Aminata Kante ,&nbsp;Beydi Niass ,&nbsp;Ramatoulaye Mane ,&nbsp;Malick Anne","doi":"10.1016/j.ijregi.2025.100568","DOIUrl":"10.1016/j.ijregi.2025.100568","url":null,"abstract":"<div><h3>Objectives</h3><div>Given the importance of immunization, establishing an innovative strategy through a community tool, “infant monitoring booklet (IMB),” seemed necessary in Goudomp to improve immunization coverage and birth registration for infants aged 0-23 months.</div></div><div><h3>Methods</h3><div>A before-and-after evaluative study of the strategy, co-created and jointly implemented by town halls and health district actors and community health workers, was conducted in Goudomp. Sampling was exhaustive, taking into account all filled IMBs available. Data collection was performed using the District Health Information System 2 platform with a locally structured closed template configured on Excel 2010 software.</div></div><div><h3>Results</h3><div>The availability of IMBs in Goudomp's villages/neighborhoods was 83%, of which 99.5% were up to date, enabling the enrollment of 3949 infants, 77% of whom were up to date on the Expanded Program on Immunization (EPI). Of these, 76% had been fully vaccinated. Indeed, before using IMB, only 56% of the EPI antigens achieved at least 90% coverage, whereas it reached 100% after implementation of the IMB strategy. The latter also allowed 1351 infants, representing 44% of EPI-monitored infants, to be referred to town halls for birth registration. Finally, 53% of Goudomp's town halls registered more births after IMB's strategy implementation than before owing to IMB use.</div></div><div><h3>Conclusions</h3><div>IMB jointly met Senegal's EPI and birth registration requirements.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100568"},"PeriodicalIF":1.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis outcomes among international migrants living in Europe compared with the nonmigrant population: A systematic review and meta-analysis","authors":"Cotugno Sergio ,&nbsp;Guido Giacomo ,&nbsp;Segala Francesco Vladimiro ,&nbsp;Frallonardo Luisa ,&nbsp;Papagni Roberta ,&nbsp;Giliberti Vincenzo ,&nbsp;Polizzotto Carla ,&nbsp;Di Franco Giuseppina ,&nbsp;Piccione Ercole ,&nbsp;Affronti Marco ,&nbsp;Gualano Gina ,&nbsp;Palmieri Fabrizio ,&nbsp;Barbagallo Mario ,&nbsp;Veronese Nicola ,&nbsp;Saracino Annalisa ,&nbsp;Di Gennaro Francesco","doi":"10.1016/j.ijregi.2024.100564","DOIUrl":"10.1016/j.ijregi.2024.100564","url":null,"abstract":"<div><h3>Objectives</h3><div>Migration status refers to socioeconomic factors that challenge access to the health care system and increase the risk of developing tuberculosis (TB) with worse outcomes. This systematic review and meta-analysis aimed to investigate the outcomes of TB among international migrants arriving in Europe compared with the nonmigrant population.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted to identify studies investigating TB-related outcomes among migrants and nonmigrants in Europe. Six investigators searched PubMed, Scopus, and Web of Science from inception to March 2024 and screened the abstracts of potentially eligible articles. Studies reporting TB-related outcomes in both migrants and nonmigrants were also included. Studies with migrant definitions other than the one from the inclusion criteria, with no control group, and with no discernible data, including nonhuman samples or written in a non-English language, were excluded. Data were reported as relative risks (RRs) or odds ratios with their 95% confidence intervals (CIs). The risk of bias was assessed using the Newcastle–Ottawa Scale (PROSPERO Registration number: CRD42024529629).</div></div><div><h3>Results</h3><div>Of the 1,109 papers screened, 34 were included, consisting of 601,293 participants (459,670 nonmigrants and 141,623 migrants). The meta-analysis, adjusted for potential confounders, showed that migrants presented a lower mortality risk (RR = 0.391, 95% CI: 0.276-0.554; <em>P</em> &lt;0.0001; I² = 71.6%), a lower rate of treatment completion (RR = 0.313; 95% CI: 0.163-0.600; <em>P</em> &lt;0.0001), and a higher rate of loss to follow-up (RR = 4.331, 95% CI: 1.542-12.163, <em>P</em> = 0.005; I² = 55.8%). Treatment success, cure, not evaluated, and sustained treatment success showed no significant differences between migrants and nonmigrants. No adjusted analyses could be performed for cure, not evaluated, and sustained treatment success. Only three studies had a high risk of bias.</div></div><div><h3>Conclusions</h3><div>Migrants living in Europe have lower mortality rates; however, TB management is affected by a higher risk of loss to follow-up and discontinuation. Therefore, migrant-targeted TB care is necessary to improve the fight against TB in Europe.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100564"},"PeriodicalIF":1.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the qSOFA score and SIRS criteria to predict 30-day mortality in patients with suspected infection in a university hospital ward in Recife, Brazil: A retrospective cohort study","authors":"Pedro Alves da Cruz Gouveia ,&nbsp;Nayron Veloso Resende ,&nbsp;Sara Menezes Lima Soares ,&nbsp;Denise Maria do Nascimento Costa ,&nbsp;Vera Magalhães da Silveira","doi":"10.1016/j.ijregi.2025.100567","DOIUrl":"10.1016/j.ijregi.2025.100567","url":null,"abstract":"<div><div><em>Objectives:</em> This study aimed to assess the accuracy of quick sequential organ failure assessment (qSOFA) and systemic inflammatory response syndrome (SIRS) in predicting 30-day mortality in patients with suspected infections in a ward environment.</div><div><em>Methods:</em> Retrospective observational cohort study with adult patients admitted to the medical ward who began their first antibiotic regimen for a presumed infection. The qSOFA and SIRS were calculated at the time antibiotics were initiated. Multivariate logistic regression and receiver operating characteristic (ROC) curves were used to assess the predictive abilities of both scores.</div><div><em>Results:</em> Of the 244 patients, 68 (28%) died. A qSOFA ≥2 was found in 75 (31%) patients, and 233 (95%) patients met at least two SIRS criteria. Significant associations with 30-day mortality included age over 60 years, cancer, respiratory infection, and elevated qSOFA. The discrimination of 30-day mortality using the area under the ROC curve for qSOFA was 0.68 (95% confidence interval 0.60-0.77), whereas the SIRS area under the ROC curve was 0.59 (95% confidence interval 0.51-0.67), with no significant difference between the two curves (<em>P</em> = 0.056).</div><div><em>Conclusions:</em> qSOFA and SIRS performed poorly in predicting 30-day mortality in ward patients with suspected infections, indicating a need for better prognostic tools in these settings.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100567"},"PeriodicalIF":1.5,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality Associated with Surgical Site Infections Following Cardiac Surgery: Insights from the International ID-IRI Study","authors":"Hakan Erdem ,&nbsp;Handan Ankarali ,&nbsp;Jaffar A. Al-Tawfiq ,&nbsp;Kumar Angamuthu ,&nbsp;Dragan Piljic ,&nbsp;Ajdin Umihanic ,&nbsp;Farouq Dayyab ,&nbsp;Dilek Karamanlioğlu ,&nbsp;Abdullah Umut Pekok ,&nbsp;Meliha Cagla-Sonmezer ,&nbsp;Amani El-Kholy ,&nbsp;Maha Ali Gad ,&nbsp;Lazar Velicki ,&nbsp;Ozay Akyildiz ,&nbsp;Mustafa Altindis ,&nbsp;Dilşah Başkol-Elik ,&nbsp;Buket Erturk-Sengel ,&nbsp;İbrahim Kara ,&nbsp;Umit Kahraman ,&nbsp;Mehmet Özdemir ,&nbsp;Anna Giammanco","doi":"10.1016/j.ijregi.2025.100566","DOIUrl":"10.1016/j.ijregi.2025.100566","url":null,"abstract":"<div><h3>Objectives</h3><div>Surgical site infections (SSIs) after cardiac surgery increase morbidity and mortality rates. This multicenter study aimed to identify mortality risk factors associated with SSIs after heart surgery.</div></div><div><h3>Methods</h3><div>Conducted from January to March 2023, this prospective study included 167 patients aged &gt;16 years with post-heart surgery SSIs. The primary focus was the 30-day mortality. Univariate analysis and multivariate logistic regression utilizing the backward elimination method were used to establish the final model.</div></div><div><h3>Results</h3><div>Several factors significantly correlated with mortality. These included urinary catheterization (odds ratio [OR] 14.197; 90% confidence interval [CI] 12.198-91.721]), emergent surgery (OR 8.470 [90% CI 2.028-35.379]), valvular replacement (OR 4.487 [90% CI 1.001-20.627]), higher quick Sequential Organ Failure Assessment scores (OR 3.147 [90% CI 1.450-6.827]), advanced age (OR 1.075 [90% CI 1.020-1.132]), and postoperative re-interventions within 30 days after SSI (OR 14.832 [90% CI 2.684-81.972]). No pathogens were isolated from the wound cultures of 53 (31.7%) patients. A total of 43.1% of SSIs (n = 72) were due to gram-positive microorganisms, whereas 27.5% of cases (n = 46) involved gram-negatives. Among the gram-positive bacteria, <em>Staphylococci</em> (n = 30, 17.9%) were the predominant microorganisms, whereas <em>Klebsiella</em> (n = 16, 9.6%), <em>Escherichia coli</em> (n = 9, 5.4%), and <em>Pseudomonas aeruginosa</em> (n = 7, 4.2%) were the most prevalent.</div></div><div><h3>Conclusions</h3><div>To mitigate mortality after heart surgery, stringent infection control measures and effective surgical antisepsis are crucial, particularly, in the elderly. The clinical progression of the disease is reflected by the quick Sequential Organ Failure Assessment score and patient re-intervention, and effective treatment is another essential component of SSI management.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100566"},"PeriodicalIF":1.5,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}