IJID regions最新文献

{"title":"The long road ahead toward elimination of HPV as a global public health threat","authors":"Yao-Chun Hsu","doi":"10.1016/j.ijregi.2024.100526","DOIUrl":"10.1016/j.ijregi.2024.100526","url":null,"abstract":"<div><div>Hepatitis B virus (HBV) remains a significant global public health threat, with approximately 250 to 300 million people worldwide living with chronic HBV infection. Although effective vaccines and antiviral treatments have been available for decades, HBV is still responsible for an estimated 820,000 deaths annually, highlighting the persistent challenges in eliminating HBV as a public health threat.</div><div>This presentation begins by discussing the global burden of HBV, emphasizing the increase in the death toll despite a decrease in prevalence. Key prevention strategies are reviewed, including universal infant vaccination with an emphasis on the timely birth dose, catch-up vaccination for unimmunized adults, and antiviral prophylaxis for mothers with high viral loads to prevent breakthrough transmission. The difficulties in implementing these strategies are discussed, focusing on disparities in resource availability.</div><div>For people living with HBV, the importance of early diagnosis and linkage to care are emphasized. Furthermore, the roles of antiviral treatment in reducing the complication risks are discussed. The care cascade faces many hurdles that hinder progress toward HBV elimination, including the lack of awareness and stigma surrounding the infection, limited access to diagnostics and treatment, and difficulties in adherence to long-term care. The presenter advocates for a strengthened healthcare system with patient-centered approaches. Potential actions to overcome these hurdles are addressed.</div><div>By examining the global burden of HBV and the limitations of current strategies, this presentation outlines a roadmap for the future. It underscores the need for sustained commitment, interdisciplinary collaboration, equitable access to care, and the promotion of research and innovation to ultimately eliminate HBV as a public health threat.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100526"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 WHO influenza treatment guidelines, limitations and gaps","authors":"Timothy Uyeki","doi":"10.1016/j.ijregi.2024.100521","DOIUrl":"10.1016/j.ijregi.2024.100521","url":null,"abstract":"<div><div>In 2022, the World Health Organization (WHO) released “Guidelines for the clinical management of severe illness from influenza virus infections.” This was based upon recommendations of a WHO Guidelines Development Group during consultations in 2017-2019. The WHO has updated the recommendations to incorporate new evidence and to expand the scope to include antiviral treatment of non-severe influenza and post-exposure antiviral chemoprophylaxis of influenza. The updated guidelines address seasonal influenza and novel influenza A virus infections of animal origin (zoonotic influenza) and utilized the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to assess data from randomized controlled trials. Updated systematic reviews on antivirals, immunomodulators, other potential therapies, and influenza tests were conducted. For antivirals, network meta-analyses were performed. A WHO Guidelines Development Group provided consensus thresholds for minimally important differences of endpoints from a patient's perspective for non-severe (outpatients) and severe (hospitalized patients) influenza. The recommendations for the updated 2024 “WHO Guidelines for the clinical management of illness from influenza virus infections” will be presented. Limitations of the guidelines and gaps in clinical research for seasonal influenza and zoonotic influenza will be discussed.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100521"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echovirus 11 outbreak among neonates in Selangor, Malaysia: An epidemiological investigation","authors":"Jun Fai Yap ,&nbsp;Zaharah Zainuddin ,&nbsp;Soo Cheng Lee","doi":"10.1016/j.ijregi.2024.100546","DOIUrl":"10.1016/j.ijregi.2024.100546","url":null,"abstract":"<div><h3>Introduction</h3><div>Community outbreaks involving enteroviruses, particularly Echovirus 11 pose a significant threat to neonates. We aim to present descriptive findings from an epidemiological investigation of a disease outbreak among neonates in two confinement centres located in an urban district of Selangor state, Malaysia, between November and December 2023.</div></div><div><h3>Material and Methods</h3><div>We conducted a walk-through survey, environmental inspection and laboratory investigations in two confinement centres designated as A and B. Rectal swabs were collected to detect the presence of enteroviruses with further viral sequencing.</div></div><div><h3>Results</h3><div>In total, ten neonates in the two confinement centres were infected with Echovirus 11, resulting in a total attack rate of 40.0% among the 17 neonates and 8 adult staff members. All infected neonates were of Chinese ethnicity. No epidemiological link was found between cases in confinement centre A and those in centre B. None of the adult close contacts tested positive for Echovirus 11. Sixty percent of the infected neonates presented with fever, while approximately 33.3% exhibited symptoms of meningoencephalitis. All cases required hospitalization, with the exception of one fatality, resulting in a mortality rate of 10.0%. Although disposable diapers were used for all neonates, they were not disposed of immediately after being changed. Disinfection of the bathing basin consisted solely of using Dettol antiseptic liquid.</div></div><div><h3>Discussion</h3><div>The likely source of this Echovirus 11 outbreak was community-acquired, with the fecal-oral route identified as the most probable mode of transmission. Echovirus 11 infection, when not manifested as hand-foot-and-mouth-disease, is not a notifiable disease in Malaysia. Regular disinfection with Dettol (which contains the key active ingredient Chloroxylenol) was deemed inadequate. Therefore, emphasizing the importance of thorough handwashing with soap and water, implementing measures such as prohibiting new admissions or ensuring proper disposal of diapers are essential steps to prevent future outbreaks.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100546"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of migration status on HIV pre-exposure prophylaxis (PrEP) uptake among gay and bisexual men in Australia: Results from the PrEPARE Project 2023","authors":"Simin Yu ,&nbsp;James MacGibbon ,&nbsp;Benjamin R Bavinton ,&nbsp;Sarah K Calabrese ,&nbsp;Dean Murphy ,&nbsp;Shawn Clackett ,&nbsp;Jeanne Ellard ,&nbsp;Tina Gordon ,&nbsp;Dash Heath-Paynter ,&nbsp;Andrew Heslop ,&nbsp;Angus Molyneux ,&nbsp;John de Wit ,&nbsp;Timothy R Broady ,&nbsp;Martin Holt","doi":"10.1016/j.ijregi.2024.100547","DOIUrl":"10.1016/j.ijregi.2024.100547","url":null,"abstract":"<div><h3>Introduction</h3><div>Increasing HIV diagnoses rates among migrant gay and bisexual men (GBM) in Australia highlight the importance of accessing HIV prevention, especially among recently-arrived GBM. We compared GBM who were willing to use but not using pre-exposure prophylaxis (PrEP) with current PrEP users and assessed effects of migration status on PrEP uptake.</div></div><div><h3>Material and Methods</h3><div>A national, online cross-sectional survey of GBM was conducted in June–July 2023. Migration status was measured by region of birth and length of residency. Those willing to use but who had never used PrEP were compared with current users by logistic regression.</div></div><div><h3>Results</h3><div>Of 2,046 respondents, 1,907 (93.2%) were HIV-negative/untested with 947 (80.6%) currently using PrEP and 228 (19.4%) willing to use PrEP. Among PrEP users/willing participants (n=1,175), 28.3% were born overseas, including 4.1% who had recently arrived (lived in Australia &lt;2 years). Compared to those who were willing but had never used PrEP, current PrEP users were older (aOR=1.03, 95%CI=1.02-1.05), more likely to be employed (aOR=1.83, 95%CI=1.04-3.20), know at least one PrEP user (aOR=2.05, 95%CI=1.26-3.34), have received an STI diagnosis in the last year (aOR=2.37, 95%CI=1.34-4.19), report &gt;10 recent male sexual partners (aOR=11.28, 95%CI=4.24-29.96), and report condomless anal sex with casual partners in the past 6 months (aOR=4.47, 95%CI=2.83-7.08), and less likely to be recently-arrived GBM from non-high-income English-speaking countries (aOR=0.22, 95%CI=0.07-0.65),. Fewer recently-arrived GBM from non-high-income English-speaking countries used PrEP (50.0%) compared to Australian-born GBM (81.7%), GBM from high-income English-speaking countries (84.0%) and non-recently arrived GBM from other non-English-speaking countries (81.6%; <em>X</em>²(3, 1175)=30.27, p&lt;.001). Most recent arrivals spoke a language other than English at home (90.4%) and had migrated alone (82.7%), primarily for education (59.6%).</div></div><div><h3>Discussion</h3><div>PrEP uptake was concentrated among more sexually active GBM and much less common among recently-arrived GBM. Free or low-cost access schemes, supported by translators, publicised through educational institutions and PrEP users’ social networks may help promote PrEP uptake among recently-arrived GBM.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100547"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nosocomial fungal infections – an emerging threat to healthcare settings","authors":"Vincent Chi-Chung Cheng","doi":"10.1016/j.ijregi.2024.100522","DOIUrl":"10.1016/j.ijregi.2024.100522","url":null,"abstract":"<div><div>Nosocomial fungal infections pose an increasing threat to healthcare settings, presenting significant challenges to patient care and infection control practices. These infections are mostly opportunistic in nature, affecting patients with compromised immune systems, prolonged hospital stays, and exposure to invasive medical procedures, thereby contributing to significant morbidity and mortality. The epidemiology of nosocomial fungal infections has been further complicated by the COVID-19 pandemic, with a notable increase in the incidence of fungal infections among hospitalized patients, including COVID-19–associated candidiasis and COVID-19–associated pulmonary aspergillosis globally.</div><div>Among the concerning pathogens, Candida auris, a multidrug-resistant yeast species, is rapidly spreading worldwide, leading to nosocomial outbreaks. Notably, patients can remain colonized by C. auris for a prolonged period, facilitating environmental shedding and persistence on a wide range of surfaces. Given its high transmissibility, proactive infection control measures, including active surveillance cultures for high-risk patients, prompt isolation of confirmed cases, comprehensive contact tracing to identify secondary cases, and strict enforcement of hand hygiene and environmental disinfection protocols, are of paramount importance.</div><div>Other unusual fungal pathogens have also posed threats to healthcare settings. In the United States, Exserohilum rostratum, a plant pathogen that rarely causes human disease, was associated with contaminated intrathecal methylprednisolone injections, resulting in over 700 infected cases. In Hong Kong, nosocomial outbreaks of intestinal and pulmonary/cutaneous zygomycosis (Rhizopus microspores) caused by contaminated drug tablets, allopurinol, and contaminated linens were reported. Therefore, clinical vigilance is necessary to detect patients with unusual nosocomial fungal infections and ensure early recognition and control of outbreaks.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100522"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of antiviral treatment and recent vaccination on limiting probable transmission of COVID-19 in household","authors":"Chin Pok Chan ,&nbsp;Ngai Sze Wong ,&nbsp;Tsz Ho Kwan ,&nbsp;Samuel Yeung Shan Wong ,&nbsp;Shui Shan Lee","doi":"10.1016/j.ijregi.2024.100537","DOIUrl":"10.1016/j.ijregi.2024.100537","url":null,"abstract":"<div><h3>Introduction</h3><div>Antiviral treatment and prior vaccination reduce the progression to severe COVID-19. Yet, their effectiveness in preventing onward transmission was understudied. This study evaluates the impact of antiviral treatment and recent vaccination on the risk of probable COVID-19 transmission in households.</div></div><div><h3>Material and Methods</h3><div>In a population cohort study in Hong Kong, participants were asked to detail any incident SARS-CoV-2 infections through monthly surveys. For episodes reported to have acquired from a non-household source, any presentation of respiratory symptoms among co-living members in the same month was enquired. Presuming a secondary attack, the likelihood of household transmission was assessed in cases with and without receiving antiviral treatment and recent vaccination (within 3 months) using multiple logistic regression, controlling for demographics and household size.</div></div><div><h3>Results</h3><div>Between January 2023 and January 2024, totally 883 non-hospitalised COVID-19 episodes were reported by 866 participants with 40% male and a median age of 48 years (IQR 36-58). Among 773 episodes (89%) with medical follow-up, 22% were prescribed with either molnupiravir or nirmatrelvir/ritonavir. Among cases with antivirals prescribed, respiratory symptoms emerged in 39% of their co-living members as a sign of household transmission, compared to 49% and 55% among those without antiviral prescription and seeking medical advice, respectively. Likewise, symptom presentation was less commonly reported in co-living members of cases who were recently vaccinated (39% vs 49%). Assuming that those symptoms resulted from secondary attacks, cases treated with antivirals were significantly less likely to generate onward transmission, relative to those without prescription (adjusted odds ratio [aOR] 0.90) and seeking consultation (aOR 0.86). With no similar association identified for recently vaccinated cases, a significantly shorter symptomatic period was however noted (5.45 vs 7.55 days).</div></div><div><h3>Discussion</h3><div>The use of COVID-19 antivirals could likely mitigate one's infectiousness. Complementary to timely vaccination for abridging symptomatic illness, antiviral treatment should be initiated early to limit onward transmission.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100537"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antigen-based skin testing for TB infection diagnosis","authors":"Kin Wang To","doi":"10.1016/j.ijregi.2024.100525","DOIUrl":"10.1016/j.ijregi.2024.100525","url":null,"abstract":"<div><div>Novel specific Mycobacteria Tuberculous antigen-based skin test (TBST) has been available in Denmark, Russia and China in recent years. Intuitively, TBST is the in-vivo version of IGRA as the principle of TBST is similar to the interferon gamma release assay (IGRA). Thus, TBST is an alternative for identifying tuberculous infection (TBI), especially in subjects with history of BCG vaccination. Majority of the clinical studies have shown promising sensitivity, specificity and safety profile. However, there are still some clinical questions that need to be addressed before the TBST can replace the conventional tuberculin skin test (TST). For example, no clinical studies have addressed the predictive value of TBST with the development of active TB, and there are hardly any studies powered to show the cost effectiveness of TBST on the health economics for preventing development of TBI into active TB. Moreover, generalisation of the test results to general population is problematic as the methodologies and subjects in clinical studies are very heterogeneous. For example, some studies are retrospective with biased samples with high probability of TBI. TST and IGRA were used as the gold standard for comparison, the clinical implication of some of the discordant results were not clear. Therefore, although TBST is a promising test which overcomes some shortcomings of TST, more clinical data are needed to support its general application globally.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100525"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis D and HIV coinfection","authors":"Fujie Zhang","doi":"10.1016/j.ijregi.2024.100530","DOIUrl":"10.1016/j.ijregi.2024.100530","url":null,"abstract":"<div><div>Hepatitis delta virus (HDV) infection requires hepatitis B virus (HBV) to replicate, which occurs in either HBV/HDV co-infection or following HBV infection (super-infection). The number of HDV infections has decreased globally since the introduction of universal neonatal HBV vaccination programme. However, the existing number of individuals with HBV infections is high among those who did not receive HBV vaccination. In China, with high burden of HBV infections, understanding the epidemiology of HDV, including the prevalence and molecular characteristics, is important. The prevalence of HDV was likely to vary spatially, and HIV infection is an important risk factor for HDV infection in China. Comparing with individuals with HBV monoinfections, the prevalence of HDV was higher in individuals with HBV/HIV infections. Strategic prevention and control of HDV epidemic is needed.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100530"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of multidrug resistant Salmonella enterica and antimicrobial resistance plasmids isolated from clinical and community sources using phenotypic testing and hybrid whole genome sequencing","authors":"Nattharee Thanawan ,&nbsp;Perapon Nitayanon ,&nbsp;Witoon Thirakittiwatthana ,&nbsp;Tanit Boonsiri ,&nbsp;Pimwan Thongdee ,&nbsp;Chanwit Tribuddharat","doi":"10.1016/j.ijregi.2024.100534","DOIUrl":"10.1016/j.ijregi.2024.100534","url":null,"abstract":"<div><h3>Introduction</h3><div>Antimicrobial resistance (AMR) has emerged as a critical global health problem. Sharing of genetic materials, especially plasmids, plays a key role for the dissemination of AMR across bacterial genera. Identification of resistance plasmids in community and clinical bacteria remains a significant challenge for microbiology studies. The objective of this research was to characterize multidrug-resistant (MDR) <em>S. enterica</em> isolated from clinical and community sources focusing on phenotypic properties and molecular characterization, especially resistance plasmids, using conventional assays and hybrid whole genome sequencing.</div></div><div><h3>Material and Methods</h3><div>Two hundred twenty-one of <em>S. enterica</em> was collected from clinical samples in two hospitals (n=115) and community sources such as meat products from fresh markets (n=106) in Bangkok, Thailand. Phenotypic and molecular characterization tests were conducted to select bacterial candidates for hybrid whole genome sequencing (WGS) using Illumina and Oxford nanopore platforms and data analysis was performed.</div></div><div><h3>Results</h3><div>In total, 27.15% (60/221) of Salmonella isolates was classified as MDR, exhibiting resistance to tetracycline, sulphadiazine, ampicillin, etc. Thirty isolates were selected for WGS. Each candidate contained at least twenty-nine resistance genes and various mobile genetic elements (MGEs). For plasmid analysis, twenty-three contigs were characterized as antimicrobial resistance plasmids. At alignment score ≥ 70.00%, the plasmids could be divided into the five groups. One group demonstrated the linkage between clinical plasmids and plasmids from chicken meat with 98.00% coverage and 100% identity. In addition to resistance genes, both plasmids also contained high similar plasmid stability function, mobile genetic elements and genes associated with horizontal transfer.</div></div><div><h3>Discussion</h3><div>This study showed the evidence of AMR plasmid sharing between clinical and community isolates via food chain. Such information could promote awareness regarding the dissemination of MDR plasmids.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100534"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should the HPV self-sampling be promoted in Hong Kong?","authors":"Eliza Lai-Yi Wong","doi":"10.1016/j.ijregi.2024.100527","DOIUrl":"10.1016/j.ijregi.2024.100527","url":null,"abstract":"<div><div>Routine cervical screening, together with the Human Papillomavirus (HPV) vaccination, has been proven to prevent cervical cancer effectively. Screening adherence therefore is an essential global strategy for cervical cancer elimination worldwide. In the last decade, the implementation of high-risk HPV testing with the option of self-sampling for primary screening at the national level has evolved as a key direction to increase participation in screening and eliminate cervical cancer. It provides screening alternatives for women and reduces healthcare disparities among the vulnerable population. It could be a more cost-effective strategy for strengthening the healthcare systems.</div><div>In Hong Kong, the local government has launched a territory-wide Cervical Screening Programmes for two decades to encourage women to have regular cervical screening. The rewards are the decreasing trends in the incidence and mortality of cervical cancer with an increasing coverage rate of screening. However, the latest figures revealed that only one-third of the eligible women had cervical screening within 3 years. The regular cervical screening remains a significant public health concern. Local studies suggested that HPV self-sampling is a feasible and acceptable way to increase screening coverage among the local population, especially for those under-screen women and minority groups. The COVID-19 pandemic has disrupted routine healthcare services, including cervical cancer screening. HPV self-sampling therefore also offers an alternative during times of restricted clinic access. Lessons learned from pandemic adaptations can also inform the importance of the integration of HPV self-sampling into routine cervical screening while increasing awareness, education and clear guidelines are essential for further successful implementation.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100527"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}