IJID regions最新文献

{"title":"Prevalence and determinants of nasal carriage of methicillin-resistant Staphylococcus aureus among internally displaced persons in Mogadishu, Somalia: A community based cross-sectional study","authors":"Shafie Abdulkadir Hassan ,&nbsp;Mowlid Abdikarin Mohamed ,&nbsp;Abdifetah Ibrahim Omar","doi":"10.1016/j.ijregi.2026.100851","DOIUrl":"10.1016/j.ijregi.2026.100851","url":null,"abstract":"<div><h3>Objectives</h3><div>Internal displacement creates complex health challenges, particularly regarding the spread of antimicrobial resistance (AMR). In Somalia, internally displaced persons (IDPs) reside in overcrowded settlements with limited sanitation, creating conditions that favor the transmission of methicillin-resistant <em>Staphylococcus aureus</em> (MRSA). While clinical infections are reported, community-based data on asymptomatic carriage is scarce. This study investigated the prevalence and predictors of nasal MRSA carriage among IDPs in Mogadishu.</div></div><div><h3>Methods</h3><div>A community-based cross-sectional study was conducted in the Daynile and Kahda districts of Mogadishu. A total of 428 IDPs were enrolled using systematic random sampling. Data on sociodemographics, housing, and medical history were collected via structured questionnaires. Anterior nasal swabs were cultured on Mannitol Salt Agar, and MRSA was confirmed using cefoxitin disk diffusion per Clinical &amp; Laboratory Standards Institute (CLSI) guidelines. Multivariable logistic regression was used to identify independent predictors of carriage.</div></div><div><h3>Results</h3><div>A total of 428 participants were enrolled (mean age 24.5 years). The overall prevalence of MRSA nasal carriage was 51.87% (222/428). In the multivariable analysis, the duration of displacement and household size were significant predictors of carriage. Recent arrival in the camp (1-15 months) was a strong risk factor (adjusted odds ratio = 2.92; 95% confidence interval: 1.64-5.19) compared to long-term residents. Additionally, smaller household sizes (1-4 members) showed higher odds of carriage (adjusted odds ratio = 2.08; 95% confidence interval: 1.23-3.51) compared to larger households, potentially reflecting specific housing vulnerabilities among newer, smaller family units.</div></div><div><h3>Conclusions</h3><div>The burden of MRSA carriage is exceptionally high among displaced populations in Mogadishu. The findings suggest that recent displacement and living conditions associated with newer arrivals are critical drivers of transmission. Public health interventions should target recent arrivals with improved shelter and hygiene promotion to mitigate the spread of resistant pathogens.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100851"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, clinical features, and outcomes of Mpox in children and adolescents in Uganda, August 2024–January 2025","authors":"Charity Mutesi ,&nbsp;Richard Migisha ,&nbsp;Emmanuel Okiror Okello ,&nbsp;Emmanuel Mfitundinda ,&nbsp;Janet Kobusinge Lubega ,&nbsp;Patrick Kwizera ,&nbsp;Joanita Nalwanga ,&nbsp;Hannington Katumba ,&nbsp;Joyce Owens Kobusingye ,&nbsp;Gertrude Abbo ,&nbsp;Daniel Wenani ,&nbsp;Bridget Ainembabazi ,&nbsp;Olive Namakula Loryndah ,&nbsp;Annet Namusisi ,&nbsp;Lilian Bulage ,&nbsp;Ivan Lukabwe ,&nbsp;Dansan Atim ,&nbsp;Alex Riolexus Ario","doi":"10.1016/j.ijregi.2026.100838","DOIUrl":"10.1016/j.ijregi.2026.100838","url":null,"abstract":"<div><h3>Objectives</h3><div>Recent Mpox outbreaks in Uganda have primarily affected adults, but children and adolescents are at a higher risk of severe disease. We described the epidemiology, severity, and factors associated with severe Mpox among children and adolescents in Uganda during August 2024-January 2025.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study among polymerase chain reaction-confirmed Mpox cases in patients aged 0-17 years in eight high-burden districts. Medical records were reviewed, and Mpox severity was measured using the severity scoring system. Participants’ variables were summarized using descriptive statistics and attack rates. Modified Poisson regression identified factors associated with severe disease.</div></div><div><h3>Results</h3><div>Among 160 case-patients, males (attack rate [AR] = 2.2/100,000) and females (AR = 2.1/100,000) were equally affected. Children &lt;5 years had the highest AR (3.7/100,000). Household (50%) and school (36%) exposures were most common. Overall, Mpox severity was 91% (adjusted prevalence ratio [aPR], 95% confidence interval: 87-96%). Care-seeking after 7 days from symptom onset was associated with higher severity (aPR: 1.1, 95% confidence interval: 1.03-1.3). Case fatality was 1.9%.</div></div><div><h3>Conclusions</h3><div>Children, especially those younger than 5, experienced high Mpox infection, often linked to household and school exposure. Care-seeking beyond 7 days increased disease severity. Interventions promoting early detection and timely care in households and schools could reduce Mpox-related morbidity and mortality in children and adolescents.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100838"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pharmacist counseling intervention to improve health-related quality of life in pulmonary tuberculosis: a randomized controlled trial","authors":"Rabbiya Ahmad ,&nbsp;Siti Maisharah Sheikh Ghadzi ,&nbsp;Narendar Kumar ,&nbsp;Syed Azhar Syed Sulaiman ,&nbsp;Irfhan Ali Bin Hyder Ali ,&nbsp;Fahad Hassan Baali ,&nbsp;Abdulkarim Alshammari ,&nbsp;Amer Hayat Khan","doi":"10.1016/j.ijregi.2025.100810","DOIUrl":"10.1016/j.ijregi.2025.100810","url":null,"abstract":"<div><h3>Objectives</h3><div>Pulmonary tuberculosis (PTB) often leads to impaired health-related quality of life (HRQoL). The study evaluates the impact of a pharmacist-led educational counseling intervention on the HRQOL in individuals with PTB.</div></div><div><h3>Methods</h3><div>This single-blind, randomized controlled trial employed a parallel-group design at a tertiary care hospital in Malaysia. A total of 206 adults diagnosed with PTB were randomized (1:1) to receive either standard care under the directly observed therapy (DOT) strategy (control group) or DOT plus structured pharmacist-led counseling (intervention group) for 6 months. HRQoL was assessed at baseline and at treatment completion using the EQ-5D-3L and visual analog scale (VAS). Data analyses were performed using SPSS.</div></div><div><h3>Results</h3><div>There was a statistically significant difference between the control group and the intervention group on the quality-of-life scores post-intervention. Baseline HRQoL was comparable between groups (P &gt;0.05). At treatment completion, significant improvements were observed in the intervention group compared with the control group for self-care (P = 0.03), mobility (P = 0.05), and pain/discomfort (P = 0.01). Mean VAS scores were also higher in the intervention group (P &lt;0.001).</div></div><div><h3>Conclusions</h3><div>Pharmacist-led education and counseling interventions significantly improve the quality of life of patients with PTB.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100810"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants and regional inequalities in pregnancy deworming uptake in Somalia: findings from the 2020 Somalia demographic and health survey","authors":"Ahmed Saed Hussein ,&nbsp;Ahmed Hassan Said ,&nbsp;Mubarak Hassan Mohamud ,&nbsp;Bashiir Abdirahman Guled ,&nbsp;Sharif Abdi Mohamed ,&nbsp;Ifrah Mukhtar Hussein","doi":"10.1016/j.ijregi.2026.100841","DOIUrl":"10.1016/j.ijregi.2026.100841","url":null,"abstract":"<div><h3>Objectives</h3><div>Soil-transmitted helminth (STH) infections remain widespread in Somalia, yet national evidence on deworming uptake during pregnancy is scarce. This study exams determinants and regional inequalities in pregnancy deworming uptake in Somalia: findings from the 2020 Somalia demographic and health survey (SDHS).</div></div><div><h3>Methods</h3><div>This study analyzed data from 14,419 women in the 2020 SDHS. Weighted descriptive statistics, bivariate analyses, and multivariate logistic regression were applied to identify determinants of deworming drug use. All analyses accounted for survey clustering, stratification, and sampling weights.</div></div><div><h3>Results</h3><div>National deworming coverage during pregnancy was 4.09%, among the lowest in sub-Saharan Africa. Uptake was significantly associated with antenatal care attendance (adjusted odds ratio [AOR] = 0.49), iron supplementation (AOR = 0.16), wealth (AOR = 1.81 among the richest), parity (AOR = 1.73), and maternal education (AOR = 1.72 for higher education). Marked geographic disparities were observed, with substantially higher odds in Lower Juba (AOR = 11.48), Bakool (AOR = 8.32), and Bay (AOR = 5.50) relative to Awdal. Nomadic women had increased odds of uptake (AOR = 6.01), while women in female-headed households were less likely to receive deworming (AOR = 0.86).</div></div><div><h3>Conclusions</h3><div>Deworming uptake in Somalia is critically low and shaped by socioeconomic and regional inequities, underscoring the need to improve antenatal care access and drug supply.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100841"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of comorbidity among people living with HIV/AIDS in Guyana: a cross-sectional study","authors":"Nneoma Harris ,&nbsp;Ishaku Zechariah ,&nbsp;Tariq Jagnarine","doi":"10.1016/j.ijregi.2025.100820","DOIUrl":"10.1016/j.ijregi.2025.100820","url":null,"abstract":"<div><h3>Objectives</h3><div>Comorbidities among people living with HIV/AIDS (PLHA) are increasing as life expectancy improves with antiretroviral therapy (ART). Understanding the prevalence and associated factors of these conditions in Guyana is essential for improving clinical outcomes. To evaluate the prevalence of comorbidities among PLHA in Guyana and to identify the most prevalent comorbidities and associated risk factors from January 2017 to December 2022.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional study was conducted using data from 1066 patients across 10 HIV care and treatment centers in regions 3, 4, and 10. Data were collected using a standardized tool, coded according to the International Classification of Diseases, 11th revision, and analyzed using SPSS.</div></div><div><h3>Results</h3><div>Overall, 57.2% had at least one comorbid condition, with hypertension (29.5%), obesity (12.8%), and diabetes mellitus type II (7.4%) being the most prevalent. Significant factors associated with comorbidity included age (<em>P</em> &lt; 0.001), ethnicity (<em>P</em> = 0.047), same-sex relations (<em>P</em> = 0.027), ART use (<em>P</em> &lt; 0.001), and adherence level (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Comorbidities are common among PLHA in Guyana and have important implications for HIV management. Recommendation: Implementation of routine screening and management protocols for common comorbidities in PLHA is crucial for improving patient care in Guyana.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100820"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-lasting insecticidal nets, arboviral risks, and ecological vector shifts in refugee settings","authors":"Giancarlo Ceccarelli ,&nbsp;Francesco Branda ,&nbsp;Fabio Scarpa ,&nbsp;Marta Giovanetti ,&nbsp;Massimo Ciccozzi","doi":"10.1016/j.ijregi.2025.100809","DOIUrl":"10.1016/j.ijregi.2025.100809","url":null,"abstract":"","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100809"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candidemia in the intensive care unit before and during the COVID-19 pandemic: a cross-sectional analysis","authors":"Suzan Şahin ,&nbsp;Elif Bombacı ,&nbsp;Bülent Kaya ,&nbsp;Serap Demir Tekol","doi":"10.1016/j.ijregi.2025.100807","DOIUrl":"10.1016/j.ijregi.2025.100807","url":null,"abstract":"<div><h3>Objectives</h3><div>Increased incidences of candidemia have been reported among intensive care unit (ICU) patients during the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>The study included adult patients diagnosed with candidemia in the ICU during two periods from January 1, 2017, to December 31, 2022, that were separated by the in-country declaration of COVID-19. We evaluated the incidences of candidemia during two periods marked by transformation of an old tertiary hospital into a completely new and modern facility, which took place just before the emergence of the pandemic.</div></div><div><h3>Results</h3><div>During the pre-COVID-19 and COVID-19 periods, 3796 and 10,467 patients were admitted to the ICU, of whom 61 (1.6%, incidence 2.03 per 1000 ICU-days) and 62 (0.6%, incidence 0.66 per 1000 ICU-days) patients developed candidemia, respectively. The median time to candidemia detection was significantly longer in the COVID-19 period (34 vs 29 days, <em>P</em> = 0.022). During the pre-COVID-19 period, <em>Candida parapsilosis</em> (68.9% vs 37.1%) was the most predominant species, which was superseded during the COVID-19 period by <em>C. albicans</em> (35.5% vs 16.4%). Fluconazole resistance was significantly lower in the COVID-19 period (14.5% vs 31.1%, <em>P</em> = 0.027), with a lower resistance rate of <em>C. parapsilosis</em> (21.7% vs 38.1%). Of 3,094 (29.6%) patients with COVID-19, candidemia developed in nine patients ( 0.29%) as compared with 53 patients (0.72%) without COVID-19.</div></div><div><h3>Conclusions</h3><div>Despite reports on increased incidences of candidemia among ICU patients during the COVID-19 period, lower incidences of candidemia found in the present study both during the COVID-19 period and among COVID-19 patients may be attributed to the complete transformation of our facility.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100807"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary fungal iliopsoas abscess caused by Candida albicans: a rare clinical entity","authors":"Hazem Alouani ,&nbsp;Ghazi Lâamiri ,&nbsp;Manel Yaacoubi ,&nbsp;Jasser Rchidi ,&nbsp;Mahdi Bouassida ,&nbsp;Hassen Touinsi","doi":"10.1016/j.ijregi.2026.100850","DOIUrl":"10.1016/j.ijregi.2026.100850","url":null,"abstract":"<div><h3>Introduction</h3><div>Fungal iliopsoas abscesses are exceedingly rare and typically occur in immunocompromised individuals. <em>Candida albicans</em> is an uncommon pathogen in this location and may lead to delayed diagnosis due to its nonspecific clinical features. Groin extension of such abscesses is even more unusual.</div></div><div><h3>Case presentation</h3><div>We report a diabetic male patient with a large left iliopsoas abscess extending into the groin. Imaging showed a collection exceeding 10 cm. Initial empirical therapy included fluconazole. Combined surgical and percutaneous drainage was performed. Culture of the drained pus grew <em>C. albicans</em>, confirming a fungal iliopsoas abscess. The clinical outcome was favorable.</div></div><div><h3>Discussion</h3><div>Fungal iliopsoas abscesses represent a rare subset of deep-seated fungal infections. Diabetes is an important predisposing factor. Diagnosis relies on imaging and microbiological confirmation. <em>C. albicans</em> is seldom isolated from iliopsoas collections, making this case noteworthy. Optimal management includes drainage and targeted antifungal therapy.</div></div><div><h3>Conclusion</h3><div><em>C. albicans</em> iliopsoas abscesses are rare and should be suspected in diabetic or non-responding patients. Early identification and tailored antifungal therapy are essential for successful outcomes.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100850"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effectiveness of oral cholera vaccine amid fragility: A case-control study from Eastern Sudan, 2024","authors":"Ahmad Izzoddeen ,&nbsp;Ali Abolgassim ,&nbsp;Wesam Yousif ,&nbsp;Emtiaz Atta Elhussein ,&nbsp;Eymanne ElBushra ,&nbsp;Dalya Eltayeb ,&nbsp;Muntasir M.O. Elhassan ,&nbsp;Hassan El-Bushra","doi":"10.1016/j.ijregi.2026.100842","DOIUrl":"10.1016/j.ijregi.2026.100842","url":null,"abstract":"<div><h3>Objectives</h3><div>Cholera is a serious public health threat, especially in fragile conflict-affected areas. Reactive oral cholera vaccine (rOCV) during outbreaks is a key response strategy recommended by the World Health Organization. Sudan implemented a large-scale reactive campaign during 2024 cholera outbreak in Kassala State.</div></div><div><h3>Methods</h3><div>This unmatched case-control study was conducted between 6 and 26 October 2024 in Kassala locality, targeted by the national rOCV campaign using Euvichol-Plus. Data were collected through structured interviews using a pre-tested questionnaire, and analyzed in Epi Info 7 with logistic regression to estimate vaccine effectiveness and identify predictors of infection.</div></div><div><h3>Results</h3><div>The mean age was significantly lower in cases (30.6 years, standard deviation = 20.8, <em>P</em> &lt; 0.001). Cases had bigger households and multiple families per household (<em>P</em> &lt; 0.001). Only 42.5% of cases used soap after defecation vs 97.5% of controls (odds ratio [OR] = 0.018), while 57% used only water (OR = 52.9). Street food consumption (OR = 4.04), funeral exposure (OR = 13.3), and family history (OR = 124.4) were strong predictors. OCV reduced infection odds by 93% (adjusted OR = 0.07, 95% confidence interval: 0.037-0.13, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Findings reaffirm OCV effectiveness, but emphasize the need for sustainable investment in water sanitation, and hygiene (WASH), hygiene promotion, and risk communication in fragile settings.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100842"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to perioperative antimicrobial prophylaxis in cancer surgeries: A single-center retrospective study from Oman","authors":"Bassem Awada ,&nbsp;Manal Al-Hatrushi ,&nbsp;Amal Abdallah ,&nbsp;Lamia Alnor ,&nbsp;Hasan Al-Sayegh ,&nbsp;Juma AlKasbi ,&nbsp;Amna Al-Hashar","doi":"10.1016/j.ijregi.2026.100845","DOIUrl":"10.1016/j.ijregi.2026.100845","url":null,"abstract":"<div><h3>Objectives</h3><div>Surgical antimicrobial prophylaxis (SAP) is essential for preventing surgical site infections (SSIs), particularly in oncology patients. However, adherence to SAP guidelines globally remains inconsistent. This study evaluated adherence to SAP protocols at a tertiary oncology center and assessed associated factors with non-adherence and SSI outcomes.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted at Sultan Qaboos Comprehensive Cancer and Research Center (SQCCCRC) from August 2022 to July 2023. SAP prescriptions were evaluated for four criteria: antibiotic choice, weight-based dosing, re-dosing, and duration. Non-adherence to any of the four components considered non-adherent. Demographics, cancer type, surgical procedure, wound classification, procedure duration, SSIs, and microbiology results were extracted from patient records. We used bivariate analysis and multivariable logistic regression model to identify factors associated with non-adherence. The cumulative incidence of SSIs was also calculated.</div></div><div><h3>Results</h3><div>Of the 261 surgeries reviewed, overall adherence to SAP protocols was 65%. Weight-based dosing adherence was highest (99.6%), while re-dosing adherence was lowest (80%). Univariate analyses showed non-adherence linked to higher patient weight (<em>P</em> = 0.041), male gender (<em>P</em> = 0.01), wound classification (<em>P</em> &lt; 0.001) and longer surgery duration (<em>P</em> &lt; 0.001), while breast surgery had better adherence (<em>P</em> = 0.0025). In the multivariable model, non-adherence was independently associated with gyne-oncology procedures (odds ratio [OR] = 7.76, 95% confidence interval [CI] = 2.13-30.86; <em>P</em> = 0.002) and longer surgery duration (OR = 1.35 per hour, 95% CI = 1.16-1.58; <em>P</em> = 0.0001). The cumulative incidence of SSIs was 8.4%, comprising 52% organ-spaced, 33.3% deep SSI, and 14% superficial SSIs. Non-adherent cases were more likely to have SSI compared to adherent (15.7% vs 4.7%, <em>P</em> = 0.004).</div></div><div><h3>Conclusions</h3><div>The study found suboptimal overall adherence to SAP protocols, particularly in re-dosing practices. Targeted antimicrobial stewardship interventions are warranted to address these gaps and minimize infection risk, especially in high-risk oncology populations.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100845"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}