IJID regions最新文献_第3页

Whole-genome characterization of prevalent dengue virus serotype-1 in 2023 dengue outbreak of Xishuangbanna, a border area of Laos, Myanmar, and China 2023年老挝、缅甸和中国边境地区西双版纳登革热暴发流行登革热血清1型病毒全基因组特征分析

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100797

Chenqian Peng , Tingting Li , Dehong Ma , Fen Zeng , Kaiyun Ding , Ziying Wu , Linhong Li , Yue Pan , Junying Chen , Yingcheng Guo , Qiangming Sun

Objectives

From June to November 2023, a severe dengue fever outbreak occurred in Xishuangbanna, China, a border area with Myanmar and Laos. This study aimed to identify the pathogen responsible for this outbreak and analyze the genomic characteristics of epidemic strains, providing reference data for dengue prevention and control.

Methods

Serum samples from dengue virus (DENV) NS1-positive patients (July-October 2023) were collected. RNA extraction, serotyping via probe quantitative polymerase chain reaction, and whole-genome amplification using 18 primer pairs followed by sequencing were performed. Base and amino acid mutations were analyzed using DNAMAN. Phylogenetic trees (maximum likelihood for the whole genome and neighbor-joining for the E protein) were constructed using MEGA11. Protein secondary structures were compared via online tools provided by PRABI Lyon-Gerland.

Results

Among 1465 samples, 833 were DENV-1 positive, with no other dengue serotype or flavivirus co-infection. Genomic analysis of 10 isolates showed high similarity to the 2023 Guangdong strain (PP540291). Non-structural proteins had higher base mutation rates than structural ones, with NS2 showing the highest (10.92%). Many unique 2013 Yunnan strain mutations were preserved. Phylogenetic trees clustered the epidemic strains with Guangdong and Southeast Asian isolates. NS1 RNA-binding sites remained stable.

Conclusions

This study provides valuable insights for dengue control in the China-Myanmar-Laos border areas, as well as for viral pathogenesis research and vaccine development.

目的2023年6月至11月，中国西双版纳与缅甸、老挝交界地区发生一起严重登革热疫情。本研究旨在鉴定此次暴发的病原菌，分析流行菌株的基因组特征，为登革热防控提供参考数据。方法采集2023年7 - 10月登革热病毒（DENV） ns1阳性患者血清标本。RNA提取、探针定量聚合酶链反应血清分型、18对引物全基因组扩增及测序。使用DNAMAN分析碱基和氨基酸突变。使用MEGA11构建系统发育树（全基因组的最大似然和E蛋白的邻居连接）。通过PRABI Lyon-Gerland提供的在线工具比较蛋白质二级结构。结果1465份样本中，DENV-1阳性833份，无其他登革热血清型和黄病毒合并感染。基因组分析表明，10株分离株与广东2023株（PP540291）具有较高的相似性。非结构蛋白的碱基突变率高于结构蛋白，其中以NS2最高（10.92%）。保留了许多独特的2013云南菌株突变。系统发育树将流行株与广东和东南亚分离株聚集在一起。NS1 rna结合位点保持稳定。结论本研究为中缅老边境地区登革热防控、病毒发病机制研究和疫苗研制提供了有价值的参考。

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引用次数: 0

Spa gene diversity in methicillin-resistant Staphylococcus aureus: Assessing the limits of polymerase chain reaction-based typing 耐甲氧西林金黄色葡萄球菌的Spa基因多样性：评估基于聚合酶链反应的分型的局限性

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100728

Nawfal R. Hussein , Halder J. Abozait

引用次数: 0

The prevalence of comorbidity among people living with HIV/AIDS in Guyana: a cross-sectional study 圭亚那艾滋病毒/艾滋病感染者合并症的流行：一项横断面研究

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100820

Nneoma Harris , Ishaku Zechariah , Tariq Jagnarine

Objectives

Comorbidities among people living with HIV/AIDS (PLHA) are increasing as life expectancy improves with antiretroviral therapy (ART). Understanding the prevalence and associated factors of these conditions in Guyana is essential for improving clinical outcomes. To evaluate the prevalence of comorbidities among PLHA in Guyana and to identify the most prevalent comorbidities and associated risk factors from January 2017 to December 2022.

Methods

A retrospective cross-sectional study was conducted using data from 1066 patients across 10 HIV care and treatment centers in regions 3, 4, and 10. Data were collected using a standardized tool, coded according to the International Classification of Diseases, 11th revision, and analyzed using SPSS.

Results

Overall, 57.2% had at least one comorbid condition, with hypertension (29.5%), obesity (12.8%), and diabetes mellitus type II (7.4%) being the most prevalent. Significant factors associated with comorbidity included age (P < 0.001), ethnicity (P = 0.047), same-sex relations (P = 0.027), ART use (P < 0.001), and adherence level (P < 0.001).

Conclusions

Comorbidities are common among PLHA in Guyana and have important implications for HIV management. Recommendation: Implementation of routine screening and management protocols for common comorbidities in PLHA is crucial for improving patient care in Guyana.

随着抗逆转录病毒治疗（ART）的预期寿命提高，艾滋病毒/艾滋病（PLHA）感染者的合并症正在增加。了解这些疾病在圭亚那的患病率和相关因素对于改善临床结果至关重要。评估圭亚那PLHA合并症的患病率，并确定2017年1月至2022年12月期间最普遍的合并症和相关危险因素。方法回顾性横断面研究使用了来自3、4和10地区10个艾滋病护理和治疗中心的1066名患者的数据。使用标准化工具收集数据，按照《国际疾病分类》第11版进行编码，并使用SPSS进行分析。结果总体而言，57.2%的患者至少有一种合并症，其中高血压（29.5%）、肥胖（12.8%）和II型糖尿病（7.4%）最为常见。与合并症相关的重要因素包括年龄（P < 0.001）、种族（P = 0.047）、同性关系（P = 0.027）、抗逆转录病毒治疗使用（P < 0.001）和依从性水平（P < 0.001）。结论合并症在圭亚那艾滋病病毒感染者中普遍存在，对艾滋病病毒管理具有重要意义。建议：实施常见合并症的常规筛查和管理方案对于改善圭亚那的患者护理至关重要。

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引用次数: 0

Prevalence of antimicrobial resistance in Somalia: A systematic review 索马里抗菌素耐药性流行情况：系统回顾

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100800

Shafie Abdulkadir Hassan , Mohamed Hassan Osman , Mowlid Abdikarin Mohamed

Objectives

Antimicrobial resistance (AMR) is a severe but poorly documented threat in Somalia due to its fragmented healthcare system. This study reviews AMR prevalence and clinical impact in Somalia, comparing the findings to regional trends to address this critical data gap.

Methods

This study was a systematic literature review of antimicrobial susceptibility patterns in Somalia. Data on resistance rates for common Gram-positive and Gram-negative bacteria were extracted, calculated as a proportion of resistant isolates, and then narratively synthesized in summary tables.

Results

The data reveal a critical state of AMR in Somalia. Among Gram-positive bacteria, there is a near-total prevalence of methicillin-resistant Staphylococcus aureus at 97.4%. Gram-negative bacteria like Escherichia coli show extensive resistance to common treatments (94.6% to trimethoprim-sulfamethoxazole). Multidrug resistance is rampant, with pathogens such as Acinetobacter baumannii exhibiting 100% resistance to multiple drug classes, including Reserve group carbapenems. These rates are markedly higher than in neighboring Ethiopia, highlighting a severe and escalating public health emergency.

Conclusions

Somalia’s AMR crisis has rendered standard antibiotics ineffective. Urgent action is required, including national surveillance, local treatment guidelines, and antimicrobial stewardship to control this threat.

目的抗菌素耐药性（AMR）在索马里是一个严重的威胁，但由于其支离破碎的医疗体系，记录很少。本研究回顾了索马里抗微生物药物耐药性的流行情况和临床影响，并将研究结果与区域趋势进行了比较，以解决这一关键的数据差距。方法对索马里的抗菌药物敏感性进行系统的文献综述。提取常见革兰氏阳性和革兰氏阴性细菌的耐药率数据，计算耐药菌株的比例，然后在汇总表中进行叙述合成。结果数据显示索马里的抗菌素耐药性处于危急状态。在革兰氏阳性菌中，耐甲氧西林金黄色葡萄球菌的感染率接近97.4%。革兰氏阴性菌，如大肠杆菌，对常见治疗具有广泛的耐药性（对甲氧苄啶-磺胺甲恶唑有94.6%的耐药性）。多药耐药现象十分猖獗，鲍曼不动杆菌等病原体对多种药物（包括储备类碳青霉烯类）表现出100%的耐药性。这些比率明显高于邻国埃塞俄比亚，凸显了严重和不断升级的突发公共卫生事件。索马里的抗菌素耐药性危机使标准抗生素失效。需要采取紧急行动，包括国家监测、地方治疗指南和抗微生物药物管理，以控制这一威胁。

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引用次数: 0

Characteristics and mortality factors of severe malaria in children and teenager aged from 5 to 15 years in Thiès region, Senegal 塞内加尔thi<s:1>地区5至15岁儿童和青少年严重疟疾的特征和死亡因素

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100801

Agbogbenkou Tevi Dela-Dem Lawson, Maimouna Sidibé, Mohamed Achraf Mahmoud, Bruno Hans Bidzanga Bahada, Sylvie Audrey Diop

Objectives

Severe malaria remains a major cause of pediatric morbidity and mortality. This study assessed the characteristics and mortality of severe malaria in children and adolescents in Thiès, Senegal.

Methods

Retrospective multicenter study in four multicenter referral hospitals (July 2019–June 2024), including children aged 5 to 15 hospitalized for confirmed severe malaria, defined by a positive rapid diagnostic test and/or thick blood smear, along with at least one World Health Organization (WHO) criterion (2015). Analyses used R software.

Results

We recorded 109 cases. Mean age 9.56 ± 2.87 years (5–15); sex ratio 1.95. Most patients (60%) originated from rural areas, with admissions mainly in the post-rainy season, especially in October (36.7%) and November (22.9%). Frequent signs included prostration (27%), convulsions (21.10%), coma (17.43%), alongside severe anemia (33%) and thrombocytopenia (61.62%). All patients tested positive on rapid diagnostic tests; among the 46 thick blood smear tests, 97.8% were positive. Injectable artesunate was first-line, followed by artemisinin-based combination therapy (82%); antibiotics were used in 50.46%. Outcomes were favorable in 90%, with 5.5% sequelae and 4.5% mortality. Mortality was significantly associated with respiratory distress and ≥2 WHO severity criteria.

Conclusions

The associated lethality and mortality are considerable, with notable neurological and functional sequelae observed.

目的严重疟疾仍然是儿童发病和死亡的主要原因。本研究评估了塞内加尔thi地区儿童和青少年严重疟疾的特点和死亡率。方法在4家多中心转诊医院（2019年7月- 2024年6月）进行回顾性多中心研究，纳入因确诊的严重疟疾住院的5至15岁儿童，诊断标准为快速诊断试验阳性和/或厚血涂片，并至少符合一项世界卫生组织（WHO）标准（2015年）。使用R软件进行分析。结果共记录109例。平均年龄（5 ~ 15岁）9.56±2.87岁；性别比1.95。大多数患者（60%）来自农村地区，主要在雨季后入院，特别是10月（36.7%）和11月（22.9%）。常见症状包括虚脱（27%）、抽搐（21.10%）、昏迷（17.43%），伴严重贫血（33%）和血小板减少（61.62%）。所有患者在快速诊断检测中均呈阳性；在46项厚血涂片检查中，97.8%呈阳性。注射青蒿琥酯是第一线，其次是以青蒿素为基础的联合治疗（82%）；50.46%的患者使用抗生素。90%的患者预后良好，5.5%的患者有后遗症，4.5%的患者有死亡率。死亡率与呼吸窘迫和≥2项WHO严重程度标准显著相关。结论本病致死率和死亡率高，伴有明显的神经和功能后遗症。

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引用次数: 0

Sudan and the erosion of global health ethics: reclaiming the forgotten mandate of sustainable development goals 苏丹与全球卫生伦理的侵蚀：重拾被遗忘的可持续发展目标任务

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100803

Emmanuel Edwar Siddig , Ayman Azhary , Claude Mambo Muvunyi

引用次数: 0

Resurgence of epidemics in Zinder: effect of the decrease in vaccination coverage and the impacts of climate change 津德尔流行病死灰复燃：疫苗接种覆盖率下降的影响和气候变化的影响

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100781

Doutchi Mahamadou , Adamou Bara Abdoul-Aziz , Lamine Mahaman Moustapha , Ibrahim Alkassoum , Souleymane Adoum Fils , Bagnou Hamsatou , Goni Bachir , Yacouba Abdourahmane , Manzo Farouk , Adamou Lagare , Adehossi Eric , Djibo Issifou , Nasser Hassane , Idé Habibatou , Serge Paul Eholié

Objectives

Several epidemic outbreaks have affected the Zinder region. These include diseases targeted by the expanded immunization program and other emerging diseases. This study aimed to analyze these epidemics.

Methods

This is documentary research of the epidemics of meningitis, measles, cholera, COVID-19, and diphtheria, which occurred in the Zinder region from 2015 to 2023, as well as their determinants. The data collection is made from the linear list of notifiable diseases of the Regional Directorate of Health and Public Hygiene of Zinder, associated with literature review on the determinants of the appearance of these epidemics.

Results

The number of meningitis cases has gradually increased in Zinder from 2019 to 2024. A total of 5019 cases were registered during these epidemics, with a mortality rate of 6.31%. Five measles epidemics have been recorded since 2015. A total of 13,887 cases were notified during these epidemics, with a mortality rate of 0.30%. Three cholera epidemics occurred: in 2021, in 2022, and in 2024. During these epidemics, 884 cases were recorded, with 24 deaths or a lethality of 2.71%. The COVID-19 epidemic occurred in 2020, with 364 cases, including 17 deaths, i.e. a mortality rate of 4.67%. Since 2022, the region has been facing a diphtheria epidemic. A total of 3310 cases has been reported, with 173 deaths. The causes of these epidemics are multifaceted; they involve the decline in vaccination coverage, migration, insecurity, the COVID-19 pandemic, and climate change.

Conclusions

The impact of epidemics on the health of the population and the socio-economic development of regions implies a greater mastery of the root causes mentioned in this study.

目的津德尔地区发生了多起疫情。这些疾病包括扩大免疫规划所针对的疾病和其他新出现的疾病。本研究旨在分析这些流行病。方法对2015 - 2023年津德尔地区发生的脑膜炎、麻疹、霍乱、COVID-19和白喉疫情及其影响因素进行文献调查。数据的收集是根据津德尔地区卫生和公共卫生局的应通报疾病线性清单，并结合对这些流行病出现的决定因素的文献审查。结果2019 - 2024年津德尔市脑膜炎病例数呈逐渐上升趋势。在这些流行期间共登记了5019例病例，死亡率为6.31%。自2015年以来，记录了五次麻疹流行。在这些流行病期间共报告了13 887例病例，死亡率为0.30%。发生了三次霍乱流行：2021年、2022年和2024年。在这些流行期间，记录了884例病例，其中24例死亡，致死率为2.71%。新冠肺炎疫情发生于2020年，共发生病例364例，死亡17例，死亡率4.67%。自2022年以来，该地区一直面临白喉流行病。总共报告了3310例病例，其中173例死亡。造成这些流行病的原因是多方面的；它们涉及疫苗接种覆盖率下降、移民、不安全、COVID-19大流行和气候变化。结论流行病对人口健康和地区社会经济发展的影响意味着对本研究中提到的根本原因有了更大的掌握。

{"title":"Resurgence of epidemics in Zinder: effect of the decrease in vaccination coverage and the impacts of climate change","authors":"Doutchi Mahamadou , Adamou Bara Abdoul-Aziz , Lamine Mahaman Moustapha , Ibrahim Alkassoum , Souleymane Adoum Fils , Bagnou Hamsatou , Goni Bachir , Yacouba Abdourahmane , Manzo Farouk , Adamou Lagare , Adehossi Eric , Djibo Issifou , Nasser Hassane , Idé Habibatou , Serge Paul Eholié","doi":"10.1016/j.ijregi.2025.100781","DOIUrl":"10.1016/j.ijregi.2025.100781","url":null,"abstract":"<div><h3>Objectives</h3><div>Several epidemic outbreaks have affected the Zinder region. These include diseases targeted by the expanded immunization program and other emerging diseases. This study aimed to analyze these epidemics.</div></div><div><h3>Methods</h3><div>This is documentary research of the epidemics of meningitis, measles, cholera, COVID-19, and diphtheria, which occurred in the Zinder region from 2015 to 2023, as well as their determinants. The data collection is made from the linear list of notifiable diseases of the Regional Directorate of Health and Public Hygiene of Zinder, associated with literature review on the determinants of the appearance of these epidemics.</div></div><div><h3>Results</h3><div>The number of meningitis cases has gradually increased in Zinder from 2019 to 2024. A total of 5019 cases were registered during these epidemics, with a mortality rate of 6.31%. Five measles epidemics have been recorded since 2015. A total of 13,887 cases were notified during these epidemics, with a mortality rate of 0.30%. Three cholera epidemics occurred: in 2021, in 2022, and in 2024. During these epidemics, 884 cases were recorded, with 24 deaths or a lethality of 2.71%. The COVID-19 epidemic occurred in 2020, with 364 cases, including 17 deaths, i.e. a mortality rate of 4.67%. Since 2022, the region has been facing a diphtheria epidemic. A total of 3310 cases has been reported, with 173 deaths. The causes of these epidemics are multifaceted; they involve the decline in vaccination coverage, migration, insecurity, the COVID-19 pandemic, and climate change.</div></div><div><h3>Conclusions</h3><div>The impact of epidemics on the health of the population and the socio-economic development of regions implies a greater mastery of the root causes mentioned in this study.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100781"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ceftriaxone use evaluation at the Medical Ward, Jigme Dorji Wangchuck National Referral hospital in Bhutan: A retrospective analytical study 不丹吉格梅多吉旺楚克国家转诊医院内科病房头孢曲松使用评估：回顾性分析研究

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100799

Kezang Tshering , Mongal Singh Gurung , Sonam Wangda , Pelden Chejor

Objectives

Ceftriaxone is the most commonly prescribed cephalosporin antibiotic in hospital settings. The overall prescribing compliance with the national antibiotic guidelines remained unassessed at Jigme Dorji Wangchuk National Referral Hospital (JDWNRH), Bhutan.

Methods

A retrospective analytical study was conducted by evaluating the medical records of patients who received ceftriaxone between January and December 2020 in the Medical Ward, JDWNRH. Data were analyzed using the Statistical Package for the Social Sciences, version 26.

Results

A total of 201 (17.82%) patients, with a mean age of 54.83 years (SD ± 20.93), received ceftriaxone, and pneumonia (49.25%) was the most frequently documented indication. The overall appropriate use of ceftriaxone was observed among 37 patients (18.41%), while 47 cases (23.38%) were not assessable. Doxycycline (35.82%) and metronidazole (19.90%) were the most commonly co-prescribed antibiotics. Contraindications and serious drug-drug interactions were observed among 20 (9.95%) and 21 (10.45%) patients, respectively. The proportion of inappropriate use of ceftriaxone was significantly higher among patients who experienced a hospital stay of ≤7 days (P = 0.016).

Conclusions

Routine monitoring and evaluation of ceftriaxone use as part of an antimicrobial stewardship program are recommended to prevent antibiotic resistance in the future.

目的头孢曲松是医院最常用的头孢菌素类抗生素。不丹Jigme Dorji Wangchuk国家转诊医院（JDWNRH）对国家抗生素指南的总体处方遵守情况仍未进行评估。方法对2020年1月至12月在JDWNRH内科病房接受头孢曲松治疗的患者病历进行回顾性分析。数据分析使用统计软件包的社会科学，版本26。结果201例（17.82%）患者接受头孢曲松治疗，平均年龄54.83岁（SD±20.93），肺炎是最常见的适应症（49.25%）。37例（18.41%）患者头孢曲松用药总体合理，47例（23.38%）患者用药不可评估。多西环素（35.82%）和甲硝唑（19.90%）是最常见的合用抗生素。其中禁忌症20例（9.95%），严重药物相互作用21例（10.45%）。住院时间≤7天的患者不适当使用头孢曲松的比例显著高于对照组（P = 0.016）。结论建议对头孢曲松的使用进行常规监测和评估，作为抗菌药物管理计划的一部分，以预防今后的抗生素耐药性。

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引用次数: 0

Oropouche fever: Clinical characteristics and viral–bacterial coinfections in a region of the Peruvian Amazon: A cross-sectional study Oropouche热：秘鲁亚马逊地区的临床特征和病毒-细菌共感染：一项横断面研究

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100802

Wilmer Silva-Caso , Giancarlo Pérez-Lazo , Miguel Angel Aguilar-Luis , Ronald Aquino-Ortega , Yordi Tarazona-Castro , Fernando Soto-Febres , Luis J. del Valle , Jhonathan Bazalar-Gonzales , Kocfa Chung-Delgado , Ivonne Melissa Ramírez , Sami Alcedo , Roxana Sandoval , Juana del Valle-Mendoza

Objectives

Cocirculation of Oropouche virus (OROV) with other endemic pathogens means coinfections can occur. This study aimed to characterize viral and bacterial coinfections in OROV-positive patients, evaluating their clinical features and exploring the impact on hospital stay and antibiotic use across different infection groups.

Methods

Cross-sectional study in an eastern Peruvian Amazon region among patients with acute febrile illness who tested positive for OROV. Patients were stratified into five groups: OROV monoinfection, OROV + dengue virus serotype 2 (DENV-2): American/Asian II coinfection, OROV + Rickettsia coinfection, OROV + Leptospira coinfection, and a control group of OROV-negative febrile patients.

Results

A total of 75 patients were included. Patients with OROV + Leptospira coinfection had the longest mean hospital stay (6.00 SD 1.40). Empirical antibiotic use at admission varied by group (overall 7/75, 9.3%). However, only two cases (both OROV + Leptospira) had appropriate antibiotic coverage for the confirmed pathogen. In all coinfected groups, there was frequent discordance between initial antibiotic treatment and the etiologic agent.

Conclusions

Coinfection with Leptospira was associated with a longer length of hospital stay and was the only scenario in which empiric antibiotic therapy aligned with the true etiology. OROV monoinfections and viral coinfections (with DENV-2 American/Asian II) showed similar clinical profiles, underscoring that routine clinical assessment alone cannot readily distinguish these infections or coinfections.

目的观察Oropouche病毒（OROV）与其他地方性病原体的共循环，发现可能发生共感染。本研究旨在描述orov阳性患者的病毒和细菌共感染，评估其临床特征，并探讨不同感染组对住院时间和抗生素使用的影响。方法对秘鲁东部亚马逊地区急性发热性疾病中OROV检测阳性的患者进行横断面研究。将患者分为5组：OROV单感染组、OROV +登革热病毒血清2型（DENV-2）、美洲/亚洲II型合并感染组、OROV +立克次体合并感染组、OROV +钩端螺旋体合并感染组和OROV阴性发热患者对照组。结果共纳入75例患者。OROV +钩端螺旋体合并感染的患者平均住院时间最长（6.00 SD 1.40）。入院时的经验性抗生素使用因组而异（总体为7/75,9.3%）。然而，只有两例（均为OROV +钩端螺旋体）对确诊病原体有适当的抗生素覆盖。在所有合并感染组中，初始抗生素治疗与病原之间经常存在不一致。结论钩端螺旋体感染与较长的住院时间相关，是经验性抗生素治疗与真实病因一致的唯一情况。OROV单感染和病毒合并感染（DENV-2美洲/亚洲II）表现出相似的临床特征，强调常规临床评估不能轻易区分这些感染或合并感染。

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引用次数: 0

Reply to “Spa gene diversity in MRSA: Assessing the limits of PCR-based typing” 回复“MRSA的Spa基因多样性：评估pcr分型的局限性”

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions

Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100740

Narin A. Rasheed

引用次数: 0