首页 > 最新文献

IJID regions最新文献

英文 中文
Update on the HDV seroprevalence and genotype distribution among patients positive for HBsAg referred to a National Reference Laboratory in Cameroon between January 2019 and December 2020 2019年1月至2020年12月期间向喀麦隆国家参考实验室提交的HBsAg阳性患者中HDV血清阳性率和基因型分布的最新情况
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-24 DOI: 10.1016/j.ijregi.2025.100834
Jacques Delors Toumansie Mfonkou , Yacouba Foupouapouognigni , Athenais Gerber , Ségolène Brichler , Frédéric Legal , Abdou Fatawou Modiyinji , Frederic Lissock , Laure Ngono , Boyomo Onana , Emmanuel Gordien , Richard Njouom

Objectives

Cameroon is known to be endemic for hepatitis B virus infection, but available data on hepatitis delta virus (HDV) prevalence and genetic diversity are limited, inconsistent, and outdated. This study aimed to assess the current HDV prevalence and determine the HDV genotype distribution among patients positive for hepatitis B surface antigen (HBsAg) in Cameroon.

Methods

This cross-sectional study examined patients positive for HBsAg from Cameroon’s 10 administrative regions. Anti-HDV antibodies and HDV viral load (VL) were tested using validated commercial enzyme-linked immunosorbent assay and HDV VL quantification assays. HDV genotypes were determined by the Sanger sequencing method, followed by phylogenetic analysis of the “HDV R0” genome region previously described.

Results

Of the 859 patients positive for HBsAg tested, 142 (16.5%) tested positive for anti-HDV, and HDV RNA was detected in 110 (77.5%) of them. The southern region of Cameroon had the highest infection rate. Notably, an undetectable hepatitis B virus VL was significantly associated with HDV infection (P <0.001). Patients younger than 15 years were the least infected (10%). Five genotypes—HDV-1 (the more prevalent, 83.6%), HDV-5, HDV-6, HDV-7, and HDV-8—were found in the studied population.

Conclusions

Cameroon remains an endemic country for HDV, exhibiting high prevalence, remarkable regional distribution, and wide genetic diversity.
目的已知喀麦隆是乙型肝炎病毒感染的地方,但有关丁型肝炎病毒(HDV)流行率和遗传多样性的现有数据有限、不一致且过时。本研究旨在评估目前喀麦隆乙型肝炎表面抗原(HBsAg)阳性患者中HDV的流行情况,并确定HDV基因型分布。方法横断面研究调查了来自喀麦隆10个行政区的HBsAg阳性患者。采用经验证的商用酶联免疫吸附法和HDV VL定量法检测抗HDV抗体和HDV病毒载量(VL)。通过Sanger测序法确定HDV基因型,然后对先前描述的“HDV R0”基因组区域进行系统发育分析。结果859例HBsAg阳性患者中,抗HDV阳性142例(16.5%),检出HDV RNA 110例(77.5%)。喀麦隆南部地区的感染率最高。值得注意的是,无法检测到的乙型肝炎病毒VL与HDV感染显著相关(P <0.001)。15岁以下的患者感染最少(10%)。在研究人群中发现了5种基因型:hdv -1(较普遍,占83.6%)、HDV-5、HDV-6、HDV-7和hdv -8。结论喀麦隆仍然是HDV流行的国家,具有高流行率、显著的区域分布和广泛的遗传多样性。
{"title":"Update on the HDV seroprevalence and genotype distribution among patients positive for HBsAg referred to a National Reference Laboratory in Cameroon between January 2019 and December 2020","authors":"Jacques Delors Toumansie Mfonkou ,&nbsp;Yacouba Foupouapouognigni ,&nbsp;Athenais Gerber ,&nbsp;Ségolène Brichler ,&nbsp;Frédéric Legal ,&nbsp;Abdou Fatawou Modiyinji ,&nbsp;Frederic Lissock ,&nbsp;Laure Ngono ,&nbsp;Boyomo Onana ,&nbsp;Emmanuel Gordien ,&nbsp;Richard Njouom","doi":"10.1016/j.ijregi.2025.100834","DOIUrl":"10.1016/j.ijregi.2025.100834","url":null,"abstract":"<div><h3>Objectives</h3><div>Cameroon is known to be endemic for hepatitis B virus infection, but available data on hepatitis delta virus (HDV) prevalence and genetic diversity are limited, inconsistent, and outdated. This study aimed to assess the current HDV prevalence and determine the HDV genotype distribution among patients positive for hepatitis B surface antigen (HBsAg) in Cameroon.</div></div><div><h3>Methods</h3><div>This cross-sectional study examined patients positive for HBsAg from Cameroon’s 10 administrative regions. Anti-HDV antibodies and HDV viral load (VL) were tested using validated commercial enzyme-linked immunosorbent assay and HDV VL quantification assays. HDV genotypes were determined by the Sanger sequencing method, followed by phylogenetic analysis of the “HDV R0” genome region previously described.</div></div><div><h3>Results</h3><div>Of the 859 patients positive for HBsAg tested, 142 (16.5%) tested positive for anti-HDV, and HDV RNA was detected in 110 (77.5%) of them. The southern region of Cameroon had the highest infection rate. Notably, an undetectable hepatitis B virus VL was significantly associated with HDV infection (<em>P</em> &lt;0.001). Patients younger than 15 years were the least infected (10%). Five genotypes—HDV-1 (the more prevalent, 83.6%), HDV-5, HDV-6, HDV-7, and HDV-8—were found in the studied population.</div></div><div><h3>Conclusions</h3><div>Cameroon remains an endemic country for HDV, exhibiting high prevalence, remarkable regional distribution, and wide genetic diversity.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100834"},"PeriodicalIF":1.7,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical ocular bartonellosis: A case report 非典型眼巴尔通体病1例
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-20 DOI: 10.1016/j.ijregi.2025.100830
Kamena Mwana-Yile HASSAN , Fatima IHBIBANE , Mathilde OTSASSO , Latifa MARIH

Objectives

To report a case of chorioretinitis without papilledema caused by Bartonella henselae in an immunocompetent patient.

Observations

A 27-year-old female patient with a history of multiple cat scratches presented on August 28, 2025, with a gradual decline in visual acuity in her right eye. This decline had been developing for 3 weeks following scratches from cats and was accompanied by a fever of 39°C. Optical coherence tomography revealed serous retinal detachment with associated epithelial detachment. Fluorescein angiography showed a hyperfluorescent perimacular focus in the superior temporal region, consistent with chorioretinitis characterized by star-shaped macular exudates, and there was no evidence of papilledema. HIV-1 and 2 serology was negative. Serum protein electrophoresis returned normal results, and the HbA1c level was 5.5%. Serology for B. henselae was positive (immunoglobulin [Ig]G and IgM) with titers greater than 1:1280 and 1:1200. The treatment plan included doxycycline (100 mg every 12 hours) for 6 weeks and rifampicin (300 mg every 12 hours) with corticosteroid therapy (1 mg/kg) for 4 weeks. Fluorescein angiography conducted 6 weeks after treatment showed a hypofluorescent area in the superior temporal region of the macula, indicating that the star-shaped macular exudates had disappeared. The patient reported improved visual acuity, although they experienced slight blurred vision in the right eye.

Conclusions

Ocular bartonellosis can lead to unusual eye damage, specifically chorioretinitis, even in the absence of papilledema.
目的报告1例免疫功能正常的母鸡巴尔通体引起的无乳头水肿的绒毛膜视网膜炎。患者女27岁,于2025年8月28日就诊,有多处猫抓伤史,右眼视力逐渐下降。在被猫抓伤后3周出现这种症状,并伴有39°C的发烧。光学相干断层扫描显示浆液性视网膜脱离伴相关上皮脱离。荧光素血管造影显示颞上区黄斑周围高荧光灶,符合以星形黄斑渗出物为特征的绒毛膜视网膜炎,未见乳头水肿。HIV-1、2血清学均为阴性。血清蛋白电泳正常,HbA1c水平5.5%。鸡selae B.血清免疫球蛋白G和IgM阳性,滴度分别大于1:1280和1:12 200。治疗方案包括强力霉素(100 mg/ 12小时)6周,利福平(300 mg/ 12小时)联合皮质类固醇治疗(1 mg/kg) 4周。治疗6周后荧光素血管造影显示黄斑颞上区低荧光区,表明星形黄斑渗出物消失。患者报告视力有所改善,但右眼视力略有模糊。结论即使在没有乳头水肿的情况下,眼巴尔通体病也可导致不寻常的眼部损伤,特别是绒毛膜视网膜炎。
{"title":"Atypical ocular bartonellosis: A case report","authors":"Kamena Mwana-Yile HASSAN ,&nbsp;Fatima IHBIBANE ,&nbsp;Mathilde OTSASSO ,&nbsp;Latifa MARIH","doi":"10.1016/j.ijregi.2025.100830","DOIUrl":"10.1016/j.ijregi.2025.100830","url":null,"abstract":"<div><h3>Objectives</h3><div>To report a case of chorioretinitis without papilledema caused by <em>Bartonella henselae</em> in an immunocompetent patient.</div></div><div><h3>Observations</h3><div>A 27-year-old female patient with a history of multiple cat scratches presented on August 28, 2025, with a gradual decline in visual acuity in her right eye. This decline had been developing for 3 weeks following scratches from cats and was accompanied by a fever of 39°C. Optical coherence tomography revealed serous retinal detachment with associated epithelial detachment. Fluorescein angiography showed a hyperfluorescent perimacular focus in the superior temporal region, consistent with chorioretinitis characterized by star-shaped macular exudates, and there was no evidence of papilledema. HIV-1 and 2 serology was negative. Serum protein electrophoresis returned normal results, and the HbA1c level was 5.5%. Serology for <em>B. henselae</em> was positive (immunoglobulin [Ig]G and IgM) with titers greater than 1:1280 and 1:1200. The treatment plan included doxycycline (100 mg every 12 hours) for 6 weeks and rifampicin (300 mg every 12 hours) with corticosteroid therapy (1 mg/kg) for 4 weeks. Fluorescein angiography conducted 6 weeks after treatment showed a hypofluorescent area in the superior temporal region of the macula, indicating that the star-shaped macular exudates had disappeared. The patient reported improved visual acuity, although they experienced slight blurred vision in the right eye.</div></div><div><h3>Conclusions</h3><div>Ocular bartonellosis can lead to unusual eye damage, specifically chorioretinitis, even in the absence of papilledema.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100830"},"PeriodicalIF":1.7,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent nasal colonization of rare community-acquired methicillin-resistant Staphylococcus aureus clones ST8-IVl (CA-MRSA/J) and ST1930-IVa in healthy adults 健康成人中罕见的社区获得性耐甲氧西林金黄色葡萄球菌ST8-IVl (CA-MRSA/J)和ST1930-IVa持续鼻腔定植
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-19 DOI: 10.1016/j.ijregi.2025.100827
Meiji Soe Aung , Hajime Onomi , Atsushi Taniguchi , Koji Kuronuma , Satoshi Takahashi , Nobumichi Kobayashi
As the increase in infections due to community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), monitoring of colonization in healthy population is becoming more significant. From nasal cavity of two preclinical medical students who were originally healthy and had neither foreign travel history nor contact with animals, methicillin-resistant S. aureus (MRSA) strains were isolated. For these MRSA, the genotypes, prevalence of virulence factors and antimicrobial resistance determinants were analyzed, along with antimicrobial susceptibility test. These strains were genotyped as (i) ST8-SCCmec-IVl, which was “CA-MRSA/J” clone, known as a unique Panton-Valentine leukocidin (PVL)-negative ST8 MRSA in Japan, and (ii) ST1930-SCCmec-IVa, which belonged to CC96, one of the livestock-associated MRSA, while being a rare type in humans (first detection in Japan). Both strains were susceptible to most antimicrobials, except for oxacillin, and continued to colonize the students for 1 year. These MRSA strains were successfully decolonized by the treatment with nasal ointment of mupirocin, and the eradication of ST8 MRSA strain was confirmed for at least 1 year. The present study revealed the persistent colonization of the rare CA-MRSA clones in healthy adults with unknown route of transmission, suggesting the importance to screen CA-MRSA and its decolonization in healthy individuals.
随着社区获得性耐甲氧西林金黄色葡萄球菌(CA-MRSA)感染的增加,监测健康人群的定植变得越来越重要。从2名健康、无国外旅行史、无动物接触史的临床前医学生鼻腔中分离出耐甲氧西林金黄色葡萄球菌(MRSA)。对这些MRSA进行基因型、毒力因子流行率和耐药性决定因素分析,并进行药敏试验。这些菌株的基因分型为(i) ST8- sccmec - ivl,这是“CA-MRSA/J”克隆,在日本被称为独特的Panton-Valentine白细胞介素(PVL)阴性的ST8 MRSA; (ii) ST1930-SCCmec-IVa,属于CC96,家畜相关MRSA之一,但在人类中是罕见的类型(在日本首次检测到)。这两种菌株对除肟西林外的大多数抗菌素都敏感,并持续在学生身上定殖1年。这些MRSA菌株通过使用莫匹罗星鼻软膏治疗成功地去定植,ST8 MRSA菌株被证实根除至少1年。本研究揭示了罕见的CA-MRSA克隆在健康成人中持续定植,其传播途径未知,提示筛查CA-MRSA及其在健康个体中的非定植的重要性。
{"title":"Persistent nasal colonization of rare community-acquired methicillin-resistant Staphylococcus aureus clones ST8-IVl (CA-MRSA/J) and ST1930-IVa in healthy adults","authors":"Meiji Soe Aung ,&nbsp;Hajime Onomi ,&nbsp;Atsushi Taniguchi ,&nbsp;Koji Kuronuma ,&nbsp;Satoshi Takahashi ,&nbsp;Nobumichi Kobayashi","doi":"10.1016/j.ijregi.2025.100827","DOIUrl":"10.1016/j.ijregi.2025.100827","url":null,"abstract":"<div><div>As the increase in infections due to community-acquired methicillin-resistant <em>Staphylococcus aureus</em> (CA-MRSA), monitoring of colonization in healthy population is becoming more significant. From nasal cavity of two preclinical medical students who were originally healthy and had neither foreign travel history nor contact with animals, methicillin-resistant <em>S. aureus</em> (MRSA) strains were isolated. For these MRSA, the genotypes, prevalence of virulence factors and antimicrobial resistance determinants were analyzed, along with antimicrobial susceptibility test. These strains were genotyped as (i) ST8-SCC<em>mec</em>-IVl, which was “CA-MRSA/J” clone, known as a unique Panton-Valentine leukocidin (PVL)-negative ST8 MRSA in Japan, and (ii) ST1930-SCC<em>mec</em>-IVa, which belonged to CC96, one of the livestock-associated MRSA, while being a rare type in humans (first detection in Japan). Both strains were susceptible to most antimicrobials, except for oxacillin, and continued to colonize the students for 1 year. These MRSA strains were successfully decolonized by the treatment with nasal ointment of mupirocin, and the eradication of ST8 MRSA strain was confirmed for at least 1 year. The present study revealed the persistent colonization of the rare CA-MRSA clones in healthy adults with unknown route of transmission, suggesting the importance to screen CA-MRSA and its decolonization in healthy individuals.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100827"},"PeriodicalIF":1.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival after cardiopulmonary arrest due to Capnocytophaga canimorsus sepsis: A case successfully managed using plasma exchange 嗜碳细胞吞噬败血症导致的心肺骤停后的生存:1例血浆置换成功管理
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-19 DOI: 10.1016/j.ijregi.2025.100826
Yoshio Nakano, Hiroka Serizawa, Iwao Gohma
Capnocytophaga canimorsus sepsis is potentially fatal, even in immunocompetent hosts. This report describes a case involving a 57-year-old woman, who developed fever after a dog bite and initially presented without an evident focus. On the day of admission, she deteriorated to pulseless electrical activity during transport and achieved return of spontaneous circulation after approximately 23 minutes of resuscitation. Broad-spectrum antimicrobials (meropenem) were initiated for septic shock, and Capnocytophaga canimorsus subsequently grew in both the pre-admission and admission blood cultures. Peripheral discoloration suggested purpura fulminans. A precipitous decline in platelet count, schistocytosis, elevated lactate dehydrogenase levels, and acute kidney injury fulfilled the criteria for thrombotic microangiopathy, whereas ADAMTS13 activity was normal. Intensive care consisted of red blood cell and platelet transfusions, continuous hemodiafiltration transitioning to intermittent hemodialysis, mechanical ventilation with tracheostomy, and therapeutic plasma exchange once daily for three sessions. Hematological abnormalities resolved, schistocytes disappeared, organ dysfunction improved, and she was ultimately removed from ventilation and dialysis with full neurological recovery. This report describes survival after cardiopulmonary arrest due to Capnocytophaga canimorsus sepsis and suggests that plasma exchange may be a useful adjunct for secondary thrombotic microangiopathy in this setting. Early diagnosis, prompt antibiotic treatment, and multidisciplinary critical care are essential.
即使在免疫能力强的宿主中,狼噬细胞败血症也可能致命。本报告描述了一个涉及一名57岁妇女的病例,她在被狗咬伤后出现发烧,最初没有明显的病灶。入院当天,患者在转运过程中恶化为无脉性电活动,复苏约23分钟后恢复了自发循环。广谱抗菌剂(美罗培南)开始治疗感染性休克,随后在入院前和入院血液培养中都有虎噬细胞生长。周围变色提示暴发性紫癜。血小板计数急剧下降、血吸虫病、乳酸脱氢酶水平升高和急性肾损伤符合血栓性微血管病的标准,而ADAMTS13活性正常。重症监护包括红细胞和血小板输注、持续血液滤过过渡到间歇性血液透析、气管造口机械通气和治疗性血浆置换,每天1次,共3次。血液学异常消退,血吸虫细胞消失,器官功能障碍改善,最终患者神经系统完全恢复,无需通气和透析。本报告描述了因嗜碳细胞噬噬败血症引起的心肺骤停后的生存,并提示血浆置换可能是继发性血栓性微血管病变的有用辅助手段。早期诊断、及时抗生素治疗和多学科重症监护至关重要。
{"title":"Survival after cardiopulmonary arrest due to Capnocytophaga canimorsus sepsis: A case successfully managed using plasma exchange","authors":"Yoshio Nakano,&nbsp;Hiroka Serizawa,&nbsp;Iwao Gohma","doi":"10.1016/j.ijregi.2025.100826","DOIUrl":"10.1016/j.ijregi.2025.100826","url":null,"abstract":"<div><div>Capnocytophaga canimorsus sepsis is potentially fatal, even in immunocompetent hosts. This report describes a case involving a 57-year-old woman, who developed fever after a dog bite and initially presented without an evident focus. On the day of admission, she deteriorated to pulseless electrical activity during transport and achieved return of spontaneous circulation after approximately 23 minutes of resuscitation. Broad-spectrum antimicrobials (meropenem) were initiated for septic shock, and Capnocytophaga canimorsus subsequently grew in both the pre-admission and admission blood cultures. Peripheral discoloration suggested purpura fulminans. A precipitous decline in platelet count, schistocytosis, elevated lactate dehydrogenase levels, and acute kidney injury fulfilled the criteria for thrombotic microangiopathy, whereas ADAMTS13 activity was normal. Intensive care consisted of red blood cell and platelet transfusions, continuous hemodiafiltration transitioning to intermittent hemodialysis, mechanical ventilation with tracheostomy, and therapeutic plasma exchange once daily for three sessions. Hematological abnormalities resolved, schistocytes disappeared, organ dysfunction improved, and she was ultimately removed from ventilation and dialysis with full neurological recovery. This report describes survival after cardiopulmonary arrest due to Capnocytophaga canimorsus sepsis and suggests that plasma exchange may be a useful adjunct for secondary thrombotic microangiopathy in this setting. Early diagnosis, prompt antibiotic treatment, and multidisciplinary critical care are essential.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100826"},"PeriodicalIF":1.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extensively drug-resistant tuberculosis in Togo: first reported cases and implications for tuberculosis control 多哥广泛耐药结核病:首次报告病例及其对结核病控制的影响
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-17 DOI: 10.1016/j.ijregi.2025.100825
Maïssala Zoutené , Akouvi Mawussé Edjodjinam Ako , Koffi Atsu Aziagbe , Narcisse Viani Gateu Tadjom , Tété Amento Stéphane Adambounou , Komi Séraphin Adjoh

Objectives

The increasing burden of extensively drug-resistant tuberculosis (XDR-TB) undermines global TB control efforts.

Methods

This was a case series study conducted from January 1, 2007, to December 31, 2024, in the Department of Pulmonology at Sylvanus Olympio University Teaching Hospital.

Results

We report a series of three cases. Case 1: A 30-year-old man with a history of contact with an XDR-TB case was treated with a 20-month regimen. Culture conversion was achieved at the 3rd month of treatment. A complication in the form of pyopneumothorax occurred during the 6th month of therapy. Case 2: A 51-year-old patient with no significant medical history was diagnosed with XDR-TB after 4 months of treatment for multidrug-resistant TB (MDR-TB). Conversion of follow-up cultures was achieved 2 months after modification of the treatment regimen. Case 3: A 62-year-old woman living with human immunodeficiency virus (HIV), previously treated for MDR-TB, developed XDR-TB during the course of treatment. The patient died on the 29th day of XDR-TB treatment.

Conclusions

XDR-TB is a curable disease. Early and accurate diagnosis allows for better selection of the most appropriate treatment strategy.
广泛耐药结核病(XDR-TB)负担的日益加重破坏了全球结核病控制工作。方法对2007年1月1日至2024年12月31日在希尔瓦纳斯奥林匹奥大学教学医院肺内科进行的病例系列研究。结果我们报告了三个系列病例。病例1:一名与广泛耐药结核病例有接触史的30岁男子接受了为期20个月的治疗方案。治疗第3个月实现培养转化。治疗第6个月出现气胸并发症。病例2:一名没有明显病史的51岁患者在接受耐多药结核病(MDR-TB)治疗4个月后被诊断为广泛耐药结核病。在修改治疗方案2个月后实现了随访培养的转化。病例3:一名感染人类免疫缺陷病毒(HIV)的62岁妇女,此前曾接受耐多药结核病治疗,在治疗过程中出现广泛耐药结核病。患者在广泛耐药结核治疗的第29天死亡。结论耐药结核病是一种可治愈的疾病。早期和准确的诊断可以更好地选择最合适的治疗策略。
{"title":"Extensively drug-resistant tuberculosis in Togo: first reported cases and implications for tuberculosis control","authors":"Maïssala Zoutené ,&nbsp;Akouvi Mawussé Edjodjinam Ako ,&nbsp;Koffi Atsu Aziagbe ,&nbsp;Narcisse Viani Gateu Tadjom ,&nbsp;Tété Amento Stéphane Adambounou ,&nbsp;Komi Séraphin Adjoh","doi":"10.1016/j.ijregi.2025.100825","DOIUrl":"10.1016/j.ijregi.2025.100825","url":null,"abstract":"<div><h3>Objectives</h3><div>The increasing burden of extensively drug-resistant tuberculosis (XDR-TB) undermines global TB control efforts.</div></div><div><h3>Methods</h3><div>This was a case series study conducted from January 1, 2007, to December 31, 2024, in the Department of Pulmonology at Sylvanus Olympio University Teaching Hospital.</div></div><div><h3>Results</h3><div>We report a series of three cases. Case 1: A 30-year-old man with a history of contact with an XDR-TB case was treated with a 20-month regimen. Culture conversion was achieved at the 3<sup>rd</sup> month of treatment. A complication in the form of pyopneumothorax occurred during the 6<sup>th</sup> month of therapy. Case 2: A 51-year-old patient with no significant medical history was diagnosed with XDR-TB after 4 months of treatment for multidrug-resistant TB (MDR-TB). Conversion of follow-up cultures was achieved 2 months after modification of the treatment regimen. Case 3: A 62-year-old woman living with human immunodeficiency virus (HIV), previously treated for MDR-TB, developed XDR-TB during the course of treatment. The patient died on the 29th day of XDR-TB treatment.</div></div><div><h3>Conclusions</h3><div>XDR-TB is a curable disease. Early and accurate diagnosis allows for better selection of the most appropriate treatment strategy.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100825"},"PeriodicalIF":1.7,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-exposure prophylaxis in Guyana: linking key populations and other vulnerable groups 圭亚那的接触前预防:将关键人群和其他弱势群体联系起来
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-09 DOI: 10.1016/j.ijregi.2025.100823
Alisa Khan , Tariq Jagnarine

Objectives

Despite the introduction of pre-exposure prophylaxis (PrEP) in Guyana as an effective HIV prevention tool, its uptake remains low among key and vulnerable populations, such as men who have sex with men, sex workers, and transgender individuals. This study assessed awareness, uptake, and barriers to PrEP among seronegative individuals in Guyana and proposed strategies to improve accessibility and use.

Methods

A cross-sectional, mixed-method study was conducted among 90 seronegative adults across Regions 3, 4, 6, and 10. Quantitative data were collected via structured questionnaires, whereas qualitative insights were gathered through interviews and focus group discussions. Statistical analyses (chi-square) and thematic coding were applied.

Results

Among participants, 59% were aware of PrEP, primarily through media sources (43%), whereas only 18% had ever been offered PrEP by a health care provider. None of the participants were active users. The key barriers identified were limited access (48%), fear of side effects (27%), and inadequate provider engagement. However, 57% expressed willingness to use PrEP and 74% would recommend it to peers.

Conclusions

PrEP awareness in Guyana is moderate but constrained by systemic barriers, misinformation, and health care inaccessibility. Strengthening provider training, integrating PrEP into routine services, and community outreach are essential to improve uptake.
尽管圭亚那将暴露前预防(PrEP)作为一种有效的艾滋病毒预防工具,但在关键和弱势人群(如男男性行为者、性工作者和变性人)中,PrEP的使用率仍然很低。本研究评估了圭亚那血清阴性个体对PrEP的认识、吸收和障碍,并提出了改善可及性和使用的策略。方法采用横断面混合方法对3、4、6和10区90名血清阴性成人进行研究。通过结构化问卷收集定量数据,而通过访谈和焦点小组讨论收集定性见解。采用统计学分析(卡方)和专题编码。结果在参与者中,59%的人主要通过媒体来源(43%)了解PrEP,而只有18%的人曾经由卫生保健提供者提供PrEP。所有参与者都不是活跃用户。确定的主要障碍是获取受限(48%)、担心副作用(27%)和提供者参与不足。然而,57%的人表示愿意使用PrEP, 74%的人会向同龄人推荐。结论圭亚那对sprep的认识程度一般,但受到系统障碍、错误信息和卫生保健不可及性的制约。加强提供者培训,将预防措施纳入常规服务,以及社区外展,对于提高使用率至关重要。
{"title":"Pre-exposure prophylaxis in Guyana: linking key populations and other vulnerable groups","authors":"Alisa Khan ,&nbsp;Tariq Jagnarine","doi":"10.1016/j.ijregi.2025.100823","DOIUrl":"10.1016/j.ijregi.2025.100823","url":null,"abstract":"<div><h3>Objectives</h3><div>Despite the introduction of pre-exposure prophylaxis (PrEP) in Guyana as an effective HIV prevention tool, its uptake remains low among key and vulnerable populations, such as men who have sex with men, sex workers, and transgender individuals. This study assessed awareness, uptake, and barriers to PrEP among seronegative individuals in Guyana and proposed strategies to improve accessibility and use.</div></div><div><h3>Methods</h3><div>A cross-sectional, mixed-method study was conducted among 90 seronegative adults across Regions 3, 4, 6, and 10. Quantitative data were collected via structured questionnaires, whereas qualitative insights were gathered through interviews and focus group discussions. Statistical analyses (chi-square) and thematic coding were applied.</div></div><div><h3>Results</h3><div>Among participants, 59% were aware of PrEP, primarily through media sources (43%), whereas only 18% had ever been offered PrEP by a health care provider. None of the participants were active users. The key barriers identified were limited access (48%), fear of side effects (27%), and inadequate provider engagement. However, 57% expressed willingness to use PrEP and 74% would recommend it to peers.</div></div><div><h3>Conclusions</h3><div>PrEP awareness in Guyana is moderate but constrained by systemic barriers, misinformation, and health care inaccessibility. Strengthening provider training, integrating PrEP into routine services, and community outreach are essential to improve uptake.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100823"},"PeriodicalIF":1.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Agreement and systematic bias between QuantiFERON chemiluminescent immunoassay and QuantiFERON enzyme-linked immunosorbent assay in the detection of latent tuberculosis infection: A systematic review and meta-analysis QuantiFERON化学发光免疫分析法和QuantiFERON酶联免疫吸附法检测潜伏性结核感染的一致性和系统偏倚:一项系统综述和荟萃分析
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-07 DOI: 10.1016/j.ijregi.2025.100824
Felix Bongomin , Ivaan Pitua , Phillip Ssekamatte , Diana Sitenda , Irene Andia-Biraro , Bwambale Jonani
Objectives: Enzyme-linked immunosorbent assay (ELISA)–based QuantiFERON-TB Gold Plus (QFT-Plus ELISA) testing is associated with manual variability and indeterminate results. The transition from QFT-Plus ELISA to chemiluminescent immunoassay (CLIA) for QuantiFERON-TB Gold Plus (QFT-Plus CLIA) testing represents a significant methodological evolution that requires comprehensive evaluation. This systematic review and meta-analysis aimed to assess method agreement, characterize systematic bias patterns, evaluate clinical concordance between DiaSorin's QFT-Plus CLIA and QIAGEN's (QFT-Plus ELISA) methodologies, and determine sources of heterogeneity across diverse populations for latent tuberculosis infection (LTBI) detection.
Methods: We searched the PubMed, Embase, and Google Scholar databases from January 2019 to January 2025 for studies comparing QFT-Plus CLIA and QFT-Plus ELISA methodologies for LTBI detection. Two reviewers independently screened the studies and assessed their quality using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool. We conducted a meta-analysis of agreement measures using random-effects models, systematic bias characterization, meta-regression analysis of the sources of heterogeneity, and clinical subgroup analysis. Evidence certainty was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE). The review was registered with PROSPERO (CRD420251031884).
Results: A total of 16 studies comprising 4169 participants were included. A meta-analysis of 10 studies (n = 2932) revealed a substantial overall concordance of 88.76% (95% confidence interval [CI] 83.57-93.95). Among the seven studies with complete data to calculate positive and negative agreement measures (n = 1305), the pooled positive agreement was 91.3% (95% CI 88.95-93.65) and the negative agreement was 93.89% (95% CI 92.18-95.6). The comparative analysis revealed a mean discordance rate of 6.56% (range: 0.44-16.67%), with a weighted mean directional bias of +0.2% (showing minimal overall directional preference between platforms). Significant heterogeneity was observed (I² = 95.8%, P <0.0001), and evidence certainty was rated “very low” due to methodological limitations.
Conclusions: Diasorin's QFT-Plus CLIA and QIAGEN's QFT-Plus ELISA demonstrated substantial overall agreement in detecting LTBI, with the strongest concordance for clearly positive and negative results. Laboratories implementing QFT-Plus CLIA platforms should consider verification studies, and future research should evaluate the clinical significance of discordant results and optimize interpretive algorithms for diverse epidemiologic settings.
目的:基于酶联免疫吸附试验(ELISA)的QuantiFERON-TB Gold Plus (QFT-Plus ELISA)检测与人工变异和不确定结果相关。QuantiFERON-TB Gold Plus (QFT-Plus CLIA)检测从QFT-Plus ELISA到化学发光免疫分析法(CLIA)的转变代表了一种重要的方法学进化,需要进行全面的评估。本系统综述和荟萃分析旨在评估方法的一致性,表征系统偏倚模式,评估DiaSorin的QFT-Plus CLIA和QIAGEN的QFT-Plus ELISA方法之间的临床一致性,并确定不同人群中潜伏性结核感染(LTBI)检测的异质性来源。方法:我们检索了2019年1月至2025年1月的PubMed、Embase和谷歌Scholar数据库,以比较QFT-Plus CLIA和QFT-Plus ELISA方法检测LTBI的研究。两名审稿人独立筛选研究并使用诊断准确性研究质量评估2 (QUADAS-2)工具评估其质量。我们使用随机效应模型、系统偏倚表征、异质性来源的元回归分析和临床亚组分析对一致性测量进行了荟萃分析。证据确定性采用推荐、评估、发展和评价分级(GRADE)进行评估。该综述已在PROSPERO注册(CRD420251031884)。结果:共纳入16项研究,4169名受试者。10项研究(n = 2932)的荟萃分析显示,总体一致性为88.76%(95%可信区间[CI] 83.57-93.95)。在有完整资料计算阳性和阴性一致性测度的7项研究(n = 1305)中,阳性一致性为91.3% (95% CI 88.95-93.65),阴性一致性为93.89% (95% CI 92.18-95.6)。对比分析显示,平均不一致率为6.56%(范围:0.44-16.67%),加权平均方向偏差为+0.2%(平台之间的总体方向偏好最小)。观察到显著的异质性(I²= 95.8%,P <0.0001),由于方法学的限制,证据确定性被评为“非常低”。结论:Diasorin的QFT-Plus CLIA和QIAGEN的QFT-Plus ELISA在检测LTBI方面显示出大量的总体一致性,在明确的阳性和阴性结果方面具有最强的一致性。实施QFT-Plus CLIA平台的实验室应考虑验证研究,未来的研究应评估不一致结果的临床意义,并优化不同流行病学背景下的解释算法。
{"title":"Agreement and systematic bias between QuantiFERON chemiluminescent immunoassay and QuantiFERON enzyme-linked immunosorbent assay in the detection of latent tuberculosis infection: A systematic review and meta-analysis","authors":"Felix Bongomin ,&nbsp;Ivaan Pitua ,&nbsp;Phillip Ssekamatte ,&nbsp;Diana Sitenda ,&nbsp;Irene Andia-Biraro ,&nbsp;Bwambale Jonani","doi":"10.1016/j.ijregi.2025.100824","DOIUrl":"10.1016/j.ijregi.2025.100824","url":null,"abstract":"<div><div>Objectives: Enzyme-linked immunosorbent assay (ELISA)–based QuantiFERON-TB Gold Plus (QFT-Plus ELISA) testing is associated with manual variability and indeterminate results. The transition from QFT-Plus ELISA to chemiluminescent immunoassay (CLIA) for QuantiFERON-TB Gold Plus (QFT-Plus CLIA) testing represents a significant methodological evolution that requires comprehensive evaluation. This systematic review and meta-analysis aimed to assess method agreement, characterize systematic bias patterns, evaluate clinical concordance between DiaSorin's QFT-Plus CLIA and QIAGEN's (QFT-Plus ELISA) methodologies, and determine sources of heterogeneity across diverse populations for latent tuberculosis infection (LTBI) detection.</div><div>Methods: We searched the PubMed, Embase, and Google Scholar databases from January 2019 to January 2025 for studies comparing QFT-Plus CLIA and QFT-Plus ELISA methodologies for LTBI detection. Two reviewers independently screened the studies and assessed their quality using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool. We conducted a meta-analysis of agreement measures using random-effects models, systematic bias characterization, meta-regression analysis of the sources of heterogeneity, and clinical subgroup analysis. Evidence certainty was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE). The review was registered with PROSPERO (CRD420251031884).</div><div>Results: A total of 16 studies comprising 4169 participants were included. A meta-analysis of 10 studies (n = 2932) revealed a substantial overall concordance of 88.76% (95% confidence interval [CI] 83.57-93.95). Among the seven studies with complete data to calculate positive and negative agreement measures (n = 1305), the pooled positive agreement was 91.3% (95% CI 88.95-93.65) and the negative agreement was 93.89% (95% CI 92.18-95.6). The comparative analysis revealed a mean discordance rate of 6.56% (range: 0.44-16.67%), with a weighted mean directional bias of +0.2% (showing minimal overall directional preference between platforms). Significant heterogeneity was observed (I² = 95.8%, <em>P</em> &lt;0.0001), and evidence certainty was rated “very low” due to methodological limitations.</div><div>Conclusions: Diasorin's QFT-Plus CLIA and QIAGEN's QFT-Plus ELISA demonstrated substantial overall agreement in detecting LTBI, with the strongest concordance for clearly positive and negative results. Laboratories implementing QFT-Plus CLIA platforms should consider verification studies, and future research should evaluate the clinical significance of discordant results and optimize interpretive algorithms for diverse epidemiologic settings.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100824"},"PeriodicalIF":1.7,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasmodium vivax elimination from India may need therapeutic efficacy studies - Informed shift to artemisinin-based treatment 在印度消灭间日疟原虫可能需要进行疗效研究——明智地转向以青蒿素为基础的治疗
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-03 DOI: 10.1016/j.ijregi.2025.100822
Meghavi Kathpalia , Loick P. Kojom Foko , Pragya Rawat , Rini Chaturvedi , Manju Rahi , Amit Sharma
India has significantly reduced its Plasmodium vivax (P. vivax, Pv) malaria burden. However, threat of chloroquine (CQ) resistance can undermine these gains. Artemisinin-based combination therapies (ACTs) have demonstrated superior efficacy compared to CQ, particularly in regions where resistance Pv has been confirmed. Their benefits include rapid parasite clearance, improved tolerability, effectiveness against mixed-species infections, and reduced relapse rates when combined with primaquine (PQ). While the World Health Organization recommends changing the first-line treatment if the total failure rate exceeds 10%, some countries have acted earlier based on surveillance of putative drug resistance molecular markers. In India, therapeutic efficacy studies (TES) coverage can be expanded is sparse along with molecular data to track early warning tools of Pv resistance. This review synthesizes clinical, molecular, and pharmacological evidence supporting a shift from CQ to ACTs for P. vivax. We argue that India may prioritize TES expansion and adopt an ACT-based regimen to sustain its elimination momentum and prevent therapeutic failure.
印度大大减少了间日疟原虫疟疾负担。然而,氯喹(CQ)耐药性的威胁可能破坏这些成果。与CQ相比,以青蒿素为基础的联合疗法(ACTs)已显示出更好的疗效,特别是在已确认Pv耐药性的地区。它们的益处包括快速清除寄生虫,提高耐受性,对混合物种感染有效,以及与伯氨喹(PQ)联合使用时降低复发率。虽然世界卫生组织建议,如果总失败率超过10%,就改变一线治疗方案,但一些国家根据对假定的耐药分子标记的监测,较早地采取了行动。在印度,治疗疗效研究(TES)的覆盖范围可以扩大,而且用于追踪Pv耐药性早期预警工具的分子数据也很少。这篇综述综合了临床、分子和药理学证据,支持间日疟原虫从CQ到ACTs的转变。我们认为印度可以优先考虑TES的扩展,并采用基于act的方案来维持其消除势头并防止治疗失败。
{"title":"Plasmodium vivax elimination from India may need therapeutic efficacy studies - Informed shift to artemisinin-based treatment","authors":"Meghavi Kathpalia ,&nbsp;Loick P. Kojom Foko ,&nbsp;Pragya Rawat ,&nbsp;Rini Chaturvedi ,&nbsp;Manju Rahi ,&nbsp;Amit Sharma","doi":"10.1016/j.ijregi.2025.100822","DOIUrl":"10.1016/j.ijregi.2025.100822","url":null,"abstract":"<div><div>India has significantly reduced its <em>Plasmodium vivax</em> (<em>P. vivax, Pv</em>) malaria burden. However, threat of chloroquine (CQ) resistance can undermine these gains. Artemisinin-based combination therapies (ACTs) have demonstrated superior efficacy compared to CQ, particularly in regions where resistance <em>Pv</em> has been confirmed. Their benefits include rapid parasite clearance, improved tolerability, effectiveness against mixed-species infections, and reduced relapse rates when combined with primaquine (PQ). While the World Health Organization recommends changing the first-line treatment if the total failure rate exceeds 10%, some countries have acted earlier based on surveillance of putative drug resistance molecular markers. In India, therapeutic efficacy studies (TES) coverage can be expanded is sparse along with molecular data to track early warning tools of <em>Pv</em> resistance. This review synthesizes clinical, molecular, and pharmacological evidence supporting a shift from CQ to ACTs for <em>P. vivax</em>. We argue that India may prioritize TES expansion and adopt an ACT-based regimen to sustain its elimination momentum and prevent therapeutic failure.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"18 ","pages":"Article 100822"},"PeriodicalIF":1.7,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The urgent need for Middle East respiratory syndrome coronavirus surveillance in Somalia 索马里急需对中东呼吸综合征冠状病毒进行监测
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100806
Kassim Abdi Jimale, Shafie Abdulkadir Hassan, Abdifetah Ibrahim Omar
{"title":"The urgent need for Middle East respiratory syndrome coronavirus surveillance in Somalia","authors":"Kassim Abdi Jimale,&nbsp;Shafie Abdulkadir Hassan,&nbsp;Abdifetah Ibrahim Omar","doi":"10.1016/j.ijregi.2025.100806","DOIUrl":"10.1016/j.ijregi.2025.100806","url":null,"abstract":"","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100806"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of dengue virus among febrile patients in urban setting of Bamako, Mali 马里巴马科城市环境中发热患者中登革热病毒流行情况
IF 1.7 Q4 INFECTIOUS DISEASES Pub Date : 2025-12-01 DOI: 10.1016/j.ijregi.2025.100788
Yacouba Cissoko , Mountaga Diallo , Hermine Meli , Emmanuel Mberkadji Dingamwal , Ibrehima Guindo , Fousseyni Kané , Dramane Ouedraogo , Bakary Monzon Diarra , Ibrahim Cisse , Daouda Thiero , Bréhima Togola , Demba Koita , Oumar Magassouba , Dramane Sogoba , Mariam Soumaré , Assetou Fofana , Issa Konate , Seydou Doumbia , Sounkalo Dao

Objectives

We aimed to determine the prevalence of dengue among febrile patients in Bamako and explore its seasonal and demographic variations.

Methods

We conducted cross-sectional surveys in July 2021 and February 2022 among febrile patients seeking care at four community health centers in Bamako. Febrile patients were enrolled, and blood samples were tested for dengue using rapid diagnostic tests and polymerase chain reaction.

Results

A total of 325 patients were enrolled (175 in July and 150 in February). The overall prevalence of dengue in communes V and VI of Bamako was 16.9%. Females were more represented (66.2%). The median age of the participants was 20 years (interquartile range: 8-30). Adult age (≥18 years) was the only factor significantly associated with an increased risk of dengue infection (odds ratio = 3.2; 95% confidence interval: 1.1-9.4).

Conclusions

The prevalence of dengue (16.9%) in communes V and VI suggests that dengue is endemic in Bamako, with a predominance among young adults and females. Adult age was identified as the only significant factor associated with increased risk. Further studies are needed for more insight into the dynamics of dengue transmission and to guide public health actions, particularly those targeting the adult population, to reduce dengue transmission in Bamako.
目的:我们旨在确定巴马科发热患者中登革热的流行情况,并探讨其季节性和人口统计学变化。方法于2021年7月和2022年2月对在巴马科4个社区卫生中心就诊的发热患者进行横断面调查。招募了发热患者,并使用快速诊断测试和聚合酶链反应对血液样本进行登革热检测。结果共纳入患者325例(7月175例,2月150例)。巴马科第五和第六社区登革热总流行率为16.9%。女性占比更高(66.2%)。参与者的年龄中位数为20岁(四分位数范围:8-30岁)。成人年龄(≥18岁)是唯一与登革热感染风险增加显著相关的因素(优势比= 3.2;95%可信区间:1.1-9.4)。结论巴马科五、六乡登革热流行率(16.9%)表明登革热在巴马科流行,以青壮年和女性为主。成年年龄被确定为与风险增加相关的唯一重要因素。需要进行进一步的研究,以便更深入地了解登革热传播的动态,并指导公共卫生行动,特别是针对成年人口的公共卫生行动,以减少巴马科的登革热传播。
{"title":"Prevalence of dengue virus among febrile patients in urban setting of Bamako, Mali","authors":"Yacouba Cissoko ,&nbsp;Mountaga Diallo ,&nbsp;Hermine Meli ,&nbsp;Emmanuel Mberkadji Dingamwal ,&nbsp;Ibrehima Guindo ,&nbsp;Fousseyni Kané ,&nbsp;Dramane Ouedraogo ,&nbsp;Bakary Monzon Diarra ,&nbsp;Ibrahim Cisse ,&nbsp;Daouda Thiero ,&nbsp;Bréhima Togola ,&nbsp;Demba Koita ,&nbsp;Oumar Magassouba ,&nbsp;Dramane Sogoba ,&nbsp;Mariam Soumaré ,&nbsp;Assetou Fofana ,&nbsp;Issa Konate ,&nbsp;Seydou Doumbia ,&nbsp;Sounkalo Dao","doi":"10.1016/j.ijregi.2025.100788","DOIUrl":"10.1016/j.ijregi.2025.100788","url":null,"abstract":"<div><h3>Objectives</h3><div>We aimed to determine the prevalence of dengue among febrile patients in Bamako and explore its seasonal and demographic variations.</div></div><div><h3>Methods</h3><div>We conducted cross-sectional surveys in July 2021 and February 2022 among febrile patients seeking care at four community health centers in Bamako. Febrile patients were enrolled, and blood samples were tested for dengue using rapid diagnostic tests and polymerase chain reaction.</div></div><div><h3>Results</h3><div>A total of 325 patients were enrolled (175 in July and 150 in February). The overall prevalence of dengue in communes V and VI of Bamako was 16.9%. Females were more represented (66.2%). The median age of the participants was 20 years (interquartile range: 8-30). Adult age (≥18 years) was the only factor significantly associated with an increased risk of dengue infection (odds ratio = 3.2; 95% confidence interval: 1.1-9.4).</div></div><div><h3>Conclusions</h3><div>The prevalence of dengue (16.9%) in communes V and VI suggests that dengue is endemic in Bamako, with a predominance among young adults and females. Adult age was identified as the only significant factor associated with increased risk. Further studies are needed for more insight into the dynamics of dengue transmission and to guide public health actions, particularly those targeting the adult population, to reduce dengue transmission in Bamako.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100788"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
IJID regions
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1