Advances in Nutrition最新文献

{"title":"Healthy Food Voucher Programs: Global Evidence on Structure, Implementation, and Nutrition-Related Outcomes","authors":"Jonathan Lara-Arevalo ,&nbsp;Camila Corvalan ,&nbsp;Isabel Pemjean ,&nbsp;Daniela Montes de Oca ,&nbsp;Shu Wen Ng ,&nbsp;Lindsey Smith Taillie","doi":"10.1016/j.advnut.2025.100530","DOIUrl":"10.1016/j.advnut.2025.100530","url":null,"abstract":"<div><div>Healthy food voucher programs (HFVPs) provide lower-income participants with benefits to purchase healthy, nutrient-dense foods and are a promising strategy for improving dietary and nutritional outcomes. HFVPs can complement policies aimed at reducing unhealthy food consumption, contributing to improved food security, dietary outcomes, and reducing nutritional disparities. Understanding the structural factors that make these programs acceptable and effective in improving dietary patterns is essential for designing impactful HFVPs. However, updated evidence on these components is limited. This narrative review focuses on incentive programs that provide voucher benefits for healthy foods, synthesizing global evidence on program structure components (i.e., participant eligibility and enrollment, benefit delivery and timing, eligible products, benefit value, program duration, retail venues, and inclusion of nutrition education) that may influence program impact. It also summarizes diet and nutrition-related outcomes by country’s income level, when possible. Key determinants of program acceptability included positive interactions with program and retail staff, available multilingual information, electronic benefits over physical ones, a variety of eligible healthy foods, and including local markets as participating venues. Additionally, offering remote enrollment options, using mail delivery or electronic benefits to avoid transportation costs, adjusting benefits for inflation and household size, allowing redemption in various retail venues, and coupling benefits with engaging nutrition education activities were factors influencing program effectiveness. Most evidence indicates that HFVPs increase the purchase and consumption of healthy foods, improve food security, and enhance nutrition knowledge. However, mixed results were found regarding diet quality indicators, physical health outcomes, and mental health. Factors such as insufficient benefit size, inflation, and rising food prices, as well as short intervention lengths, contributed to null results. Our findings underscore the potential of HFVPs to improve diets and reduce nutritional disparities; however, addressing identified barriers during program design and implementation is essential to ensure that these programs achieve their goals.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 11","pages":"Article 100530"},"PeriodicalIF":9.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ingestive Behavior and Precision Nutrition: Part of the Puzzle","authors":"Annabel Biruete ,&nbsp;Pius Sarfo Buobu ,&nbsp;Robert V Considine ,&nbsp;Erisa Met Hoxha ,&nbsp;Heather A Eicher-Miller ,&nbsp;Kimberly P Kinzig ,&nbsp;Anita A Panjwani ,&nbsp;Cordelia A Running ,&nbsp;Giorgia Rutigliani ,&nbsp;Dennis A Savaiano ,&nbsp;Amanda Veile ,&nbsp;Patricia G Wolf ,&nbsp;Richard D Mattes","doi":"10.1016/j.advnut.2025.100531","DOIUrl":"10.1016/j.advnut.2025.100531","url":null,"abstract":"<div><div>The marked individual variability in response to common dietary exposures necessitates tailoring of dietary guidance to individuals, or small groups of individuals with similar needs, to optimize health. This is a complex task requiring integration of environmental, cultural, psychological, and biological contributions. Work in the area of precision nutrition is an effort to translate science into practice. A research roadmap developed through a National Institutes of Health conference identified many of the inputs that require quantification. Better characterization of ingestive behaviors is one key area. The aim of this narrative review is to summarize current understanding of the influences of age, sex, body mass index, ethnicity, and genetics on ingestive behaviors, including culture, sensory function, appetite, dietary intake, the gut–brain axis, and microbiome. To do so, the extant literature was accessed through search engines relevant to the various topics covered. Outcomes assessed varied topically. In addition to compiling evidence on the nature and magnitude of these relationships, this review highlights the degree of individual variability in attributes or responses to an intervention. More broadly, it documents: <em>1</em>) that cause-and-effect relationships are difficult to establish as most are dynamic and interactive; <em>2</em>) there are inherent and learned contributions to both behavior and biology that will require different considerations and offer different opportunities for manipulation; <em>3</em>) a focus on intuitive approaches may not be as successful as desired; <em>4</em>) that external influences can, and often do, override internal influences of biology; and <em>5</em>) there are multiple ways to construct healthful diets. At the same time, it is vital that improved methods to characterize the multiple relevant inputs to ingestive behavior be developed. It is hoped that the evidence compiled here will inform efforts to develop precision nutrition guidance.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 11","pages":"Article 100531"},"PeriodicalIF":9.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Challenges of Incretin-Based Obesity Management Medications: Implications for Clinical Practice","authors":"Tair Ben-Porat ,&nbsp;Shiri Sherf-Dagan ,&nbsp;Marilou Côté ,&nbsp;Cherie Josephine Miner ,&nbsp;Assaf Buch","doi":"10.1016/j.advnut.2025.100522","DOIUrl":"10.1016/j.advnut.2025.100522","url":null,"abstract":"<div><div>Several novel incretin-based obesity management medications (OMMs) have recently been approved for chronic weight management in adults with obesity or overweight. These agents have demonstrated substantial weight reduction effects alongside glucoregulatory and cardioprotective benefits. However, the use of incretin-based OMMs presents nutritional challenges that remain insufficiently addressed. These include side effects such as gastrointestinal disturbances and loss of lean body mass, which may compromise nutritional status, reduce energy expenditure, and heighten risk of rebound weight gain, sarcopenia, and frailty. Moreover, although these medications effectively suppress energy intake and reduce food quantity, they may also have unintended effects on diet quality, potentially influencing macronutrient distribution, ultraprocessed food consumption, risk of vitamin and mineral deficiencies, and disordered eating behaviors, which could undermine long-term weight maintenance and the cardiometabolic benefits achieved through these pharmacotherapy agents. Emerging evidence suggests that specific dietary and behavioral strategies, such as higher protein intake, resistance training, nutrient-dense eating patterns, and fostering adaptive eating behaviors, may help mitigate nutritional challenges and physiologic deterioration during significant weight reduction while also supporting cardiometabolic health maintenance. However, the application of these strategies as adjunct treatments alongside the new OMMs remains unclear. This narrative review summarizes the current literature on these issues and proposes dietary interventions and behavioral modification strategies aimed at mitigating the adverse effects that can be associated with incretin-based OMMs. These considerations are increasingly important given the expanding use of these medications, the degree of weight reduction they induce, and the implications for specific at-risk groups, including aging populations prone to muscle and functional decline and individuals with pre-existing conditions of nutritional deficiencies, chronic diseases, and disordered eating patterns.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 11","pages":"Article 100522"},"PeriodicalIF":9.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota and Nutrition in Nursing Homes: Challenges and Translational Approaches for Healthy Aging","authors":"Cristina Jiménez-Arroyo,&nbsp;Natalia Molinero,&nbsp;M Victoria Moreno-Arribas","doi":"10.1016/j.advnut.2025.100520","DOIUrl":"10.1016/j.advnut.2025.100520","url":null,"abstract":"<div><div>The growing aging population is leading to an increase in demand for long-term care. This is particularly true in nursing homes, where residents are exposed to various challenges such as immunosenescence, frailty, multimorbidity, and dietary and environmental constraints. These interrelated factors contribute to gut microbiota alterations, underscoring the need for tailored strategies to preserve health and resilience in a long-term care setting. Despite its recognized relevance in healthy aging, the gut microbiome of institutionalized elderly remains markedly understudied. This review provides a comprehensive report of the current evidence on the interplay between diet, gut microbiota, and aging among nursing-home residents. The available literature suggests that both aging and institutional living contribute to a less favorable microbiome profile, and several contributing factors, many of them dietary, have been identified. Altered gastrointestinal physiology, malnutrition, and other common conditions in residential care, such as functional or cognitive impairments, frequently lead to changes in food intake that affect the gut ecosystem. Decline in immune system, increased infection risk, sarcopenia, cognitive deterioration, and high medication burden have also been linked to microbiota disruptions in this population. Importantly, adjusting several modifiable features of institutional care, particularly those related to diet and lifestyle, may help counteract these effects by supporting gut health. We further examine how appropriate nutritional strategies can positively influence gut microbiota composition and function, offering a pathway to promote resilience and functionality even in the presence of geriatric syndromes. In addition to identifying these challenges, this review outlines feasible, microbiota-informed strategies to improve quality of life and health outcomes. These include individualized dietary adaptations, targeted supplementation, physical activity interventions, and the integration of digital and artificial intelligence tools to support personalized nutrition. Finally, we highlight the need for standardized protocols and implementation science frameworks to enhance clinical translation, thereby advancing an integrative and as yet underrepresented perspective on microbiota-based strategies to promote healthier aging trajectories in institutionalized elderly.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 11","pages":"Article 100520"},"PeriodicalIF":9.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Universal Subconstructs of a Healthy Diet for Children and Adolescents: A Critical Review","authors":"Teresa R Schwendler ,&nbsp;Edward A Frongillo ,&nbsp;Hope C Craig ,&nbsp;Giles T Hanley-Cook ,&nbsp;Isabela Fleury Sattamini ,&nbsp;Chika Hayashi ,&nbsp;Vrinda Mehra ,&nbsp;Alissa M Pries ,&nbsp;Kuntal Saha ,&nbsp;Jennifer C Coates","doi":"10.1016/j.advnut.2025.100511","DOIUrl":"10.1016/j.advnut.2025.100511","url":null,"abstract":"<div><div>To monitor diets among children and adolescents, a thorough understanding of the underlying subconstructs of a healthy diet is needed to inform what should be measured. The aim of this study was to identify universal subconstructs of a healthy diet for children and adolescents aged 2–19 y, understand alignment with subconstructs for adults, and inform recommendations for metrics that aim to monitor the healthiness of diets among children and adolescents at global and national levels. A critical narrative review was carried out in 3 phases. Phase 1: A systematic review of literature published between 2014 and 2024 was conducted. A subset of articles (<em>n</em> = 100) was purposefully sampled based on predefined characteristics. Then, content analysis was performed to identify subconstructs of healthy diets. Phase 2: The identified dietary subconstructs were compared with the 6 subconstructs for adults recognized by the Healthy Diets Monitoring Initiative (HDMI). Phase 3: The identified subconstructs were compared with existing healthy diet metrics concurrently identified by HDMI as suitable for global monitoring of child and adolescent diets. Eight subconstructs specific to children and adolescents were identified: nutrient, energy, and food group requirements; foods and nutrients to limit or avoid; food group diversity and variety; macronutrient and energy balance; nutrient-rich foods or food groups; food safety; eating frequency; and eating regularity. Compared with the 6 subconstructs of adult healthy diets identified by HDMI, 2 subconstructs differed in their operationalization and 2 child- and adolescent-specific subconstructs were considered to be not conceptually distinct. Diet metrics identified as suitable for global monitoring of child and adolescent diets reflect nutrient, energy, and food group requirements; foods and nutrients to limit or avoid; and food group diversity and variety but no other diet subconstructs. The findings inform the development and validation of healthy diet metrics for children and adolescents.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 11","pages":"Article 100511"},"PeriodicalIF":9.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folate","authors":"Zoe Lofft ,&nbsp;Timothy J Green ,&nbsp;Angela M Devlin","doi":"10.1016/j.advnut.2025.100519","DOIUrl":"10.1016/j.advnut.2025.100519","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 11","pages":"Article 100519"},"PeriodicalIF":9.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Factors and Arrhythmic Risk in Long QT Syndrome: A Narrative Review of Mechanistic and Clinical Evidence","authors":"Andrea Mazzanti ,&nbsp;Matteo Floriano ,&nbsp;Deni Kukavica ,&nbsp;Alessandro Trancuccio ,&nbsp;Silvia G Priori","doi":"10.1016/j.advnut.2025.100525","DOIUrl":"10.1016/j.advnut.2025.100525","url":null,"abstract":"<div><div>Long QT syndrome (LQTS) is an umbrella term for a group of genetic cardiac channelopathies characterized by prolonged ventricular repolarization and increased risk of life-threatening arrhythmias. Although β-blockers and lifestyle modifications remain central to management, specific dietary components may influence repolarization and arrhythmic risk, particularly in genetically predisposed individuals. This review summarizes mechanistic and clinical evidence on the electrophysiological effects of selected nutrients, food constituents, and supplements—including grapefruit juice, licorice, over-the-counter products, and energy drinks. Gene–nutrient interactions and their impact on ion channel function, drug metabolism, and electrolyte balance are discussed. The second part of the review outlines genotype-specific considerations, such as potassium supplementation and dietary guidance for rare forms of LQTS, including Andersen-Tawil and Timothy syndromes. Clinical data are presented in tabular format to facilitate interpretation. By integrating mechanistic and clinical data, the review aims to support dietary counseling and inform clinical decision making in the management of LQTS.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 11","pages":"Article 100525"},"PeriodicalIF":9.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-Based Diets and Cognitive Outcomes: A Systematic Review and Meta-analysis","authors":"Catherine Bigras ,&nbsp;Riccardo Mazzoli ,&nbsp;Danielle Laurin ,&nbsp;Marcella Malavolti ,&nbsp;Giulia Barbolini ,&nbsp;Marco Vinceti ,&nbsp;Jean-Philippe Drouin-Chartier ,&nbsp;Tommaso Filippini","doi":"10.1016/j.advnut.2025.100537","DOIUrl":"10.1016/j.advnut.2025.100537","url":null,"abstract":"<div><div>Although plant-rich dietary patterns like the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diets have been linked to cognitive benefits, the role of predominantly plant-based diets is less understood. This systematic review aimed to evaluate the association between plant-based diets and cognitive outcomes. A literature search was conducted in Medline and Embase using keywords related to plant-based diets (e.g., “vegetarian diet”) and cognitive outcomes (e.g., “dementia”). Studies of any design were eligible. Reviewers independently screened studies, extracted data, and assessed quality using the Newcastle-Ottawa Scale. Meta-analyses were conducted on prospective studies that examined the same dietary exposure and cognitive outcome, using fixed-effects regression models. Twenty-two studies were included, with considerable variability in methodologies and outcomes. Plant-based diets were defined either categorically (e.g., vegetarian compared with nonvegetarian), or using indices of adherence, such as the healthful plant-based diet index (hPDI), with higher scores reflecting higher adherence. Two meta-analyses, each based on 2 high-quality prospective cohort studies, examined associations between plant-based diet indices and cognitive outcomes. For cognitive impairment, pooled odds ratios (95% confidence interval) for highest compared with lowest quartiles were 0.61 (0.55, 0.68; <em>I</em>^<em>2</em> = 97.1%) for plant-based diet index (PDI) and 0.68 (0.62, 0.75; <em>I</em>^<em>2</em> = 84.3%) for hPDI. For dementia, pooled hazard ratios were 1.03 (0.91, 1.17; <em>I</em>^<em>2</em> = 0%) for PDI, 0.85 (0.75, 0.97; <em>I</em>^<em>2</em> = 0%) for hPDI, and 1.17 (1.03, 1.33; <em>I</em>^<em>2</em> = 60.3%) for unhealthful PDI. These findings suggest that dietary patterns emphasizing healthful plant-based foods and limiting less healthful plant foods and animal products are associated with lower odds of cognitive impairment and risk of dementia. However, findings across individual studies were inconsistent, highlighting the need for further high-quality research.</div><div>This review was registered at PROSPERO as CRD42022380055.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 11","pages":"Article 100537"},"PeriodicalIF":9.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Values for Minerals in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study","authors":"Lindsay H Allen ,&nbsp;M Munirul Islam ,&nbsp;Gilberto Kac ,&nbsp;Kim F Michaelsen ,&nbsp;Sophie E Moore ,&nbsp;Maria Andersson ,&nbsp;Janet M Peerson ,&nbsp;Andrew M Doel ,&nbsp;Daphna K Dror ,&nbsp;Setareh Shahab-Ferdows ,&nbsp;Daniela de Barros Mucci ,&nbsp;Gabriela Torres Silva ,&nbsp;Daniela Hampel","doi":"10.1016/j.advnut.2025.100431","DOIUrl":"10.1016/j.advnut.2025.100431","url":null,"abstract":"<div><div>This fifth article in the series presenting reference values for nutrients in human milk describes minerals. The Mothers, Infants and Lactation Quality (MILQ) and Early-MILQ studies collected human milk samples throughout the first 8.5 mo of lactation in 1242 well-nourished women in Bangladesh, Brazil, Denmark, and The Gambia. All minerals were measured by inductively coupled plasma-mass spectrometry. Although pooled MILQ medians from 1 to 6 mo are within ∼10% of the concentration used by the Institute of Medicine (IOM) for magnesium, potassium, calcium, and copper, they are ∼50% of the IOM value for zinc and selenium, and ∼75% of the IOM value for sodium and iron. For zinc, sodium, and iron, the discrepancy can be explained by the IOM’s use of values from early lactation (&lt;3 mo) when the milk nutrient concentrations are higher; in contrast, for potassium the IOM benchmark concentration is consistent with later lactation (6 mo) in MILQ. Pooled median MILQ phosphorus from 1 to 6 mo is 120% of the concentration selected by the IOM. Milk iodine concentrations in MILQ varied among sites, reflecting the differing national policies for salt iodization. Total daily median mineral intakes from 1 to 6 mo were 49%–55% of IOM adequate intakes (AIs) for zinc and selenium, 74%–90% of AIs for sodium, iron, and magnesium, and 110%–125% of AIs for copper, potassium, calcium, and phosphorus. For zinc, sodium, iron, and potassium, differences can be explained by the reference time frame during lactation. The MILQ study mineral concentrations are provided as percentile curves to enable comparison and interpretation. Importantly, the MILQ data show marked changes in milk mineral concentrations during the first 6 mo of lactation, an observation often missed because of the absence of data representing a spectrum of time postpartum in previously published data.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 ","pages":"Article 100431"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Optimal Intake of Animal-Source Foods: A Scoping Review to Inform a New WHO Guideline’ [Advances in Nutrition 16 (2025) 100467]","authors":"Magali Rios-Leyvraz ,&nbsp;Jason Montez","doi":"10.1016/j.advnut.2025.100507","DOIUrl":"10.1016/j.advnut.2025.100507","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 10","pages":"Article 100507"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}