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Recommendations for Designing, Conducting, and Reporting Feeding Trials in Nutrition Research 关于在营养研究中设计、开展和报告喂养试验的建议。
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-10 DOI: 10.1016/j.advnut.2024.100283
Double-blind, placebo-controlled, randomized controlled trials are the gold standard for clinical trials in nutrition science. For trials of whole diets, dietary counseling is advantageous as they offer clinical translatability although can vary in the fidelity of the intended intervention from participant to participant and across studies. Feeding trials, in which most or all food is provided, offer high precision and can provide proof-of-concept evidence that a dietary intervention is efficacious and can also better evaluate the effect of known quantities of foods and nutrients on physiology. However, they come with additional methodological complexities. Feeding trials also call for a variety of unique methodological considerations, not least of which relate to the design and delivery of diets to participants. This review aims to provide a comprehensive summary of recommendations for design and conduct of feeding trials, encompassing domiciled and nondomiciled feeding trials. Several pertinent aspects of trial design and methodology are discussed, including defining the study population to maximize retention, safety, and generalizability of findings, recommendations for design of control interventions and optimizing blinding, and specific considerations for clinical populations. A detailed stepwise process for menu design, development, validation, and delivery are also presented. These recommendations aim to facilitate methodologic consistency and execution of high-quality feeding trials, ultimately facilitating improved understanding of the role of diet in treating disease and the underpinning mechanisms.
双盲、安慰剂对照、随机对照试验是营养科学临床试验的黄金标准。对于整体膳食试验而言,膳食咨询具有临床可转化性的优势,尽管不同的参与者和不同的研究在预期干预的忠实性方面可能存在差异。喂养试验提供了大部分或全部食物,具有很高的精确性,可以提供概念验证证据,证明膳食干预具有疗效,还可以更好地评估已知数量的食物和营养素对生理学的影响。不过,这些试验在方法上也有其复杂性。喂养试验还需要考虑各种独特的方法论因素,其中最重要的是与设计和向参与者提供饮食有关的因素。本综述旨在全面总结有关设计和开展喂养试验的建议,包括定居和非定居喂养试验。本综述讨论了试验设计和方法的几个相关方面,包括确定研究人群以最大限度地保留研究结果、研究结果的安全性和可推广性、设计对照干预和优化盲法的建议,以及临床人群的具体注意事项。此外,还介绍了菜单设计、开发、验证和交付的详细步骤。这些建议旨在促进方法的一致性和高质量喂养试验的实施,最终促进人们更好地了解饮食在治疗疾病中的作用及其基本机制。
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引用次数: 0
Magnesium and Cognitive Health in Adults: A Systematic Review and Meta-Analysis 镁与成年人的认知健康:系统回顾与元分析》。
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-01 DOI: 10.1016/j.advnut.2024.100272

Magnesium (Mg) plays a key role in neurological functioning and manifestations. However, the evidence from randomized controlled trials (RCTs) and cohorts on Mg and cognitive health among adults has not been systematically reviewed. We aimed to examine the associations of various Mg forms (supplements, dietary intake, and biomarkers) with cognitive outcomes by summarizing evidence from RCTs and cohorts. PubMed, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials were searched for relevant peer-reviewed articles published up to May 3, 2024. Three random-effects models were performed, when appropriate, to evaluate the relationship between Mg and cognitive outcomes: 1) linear meta-regression, 2) nonlinear (quadratic) meta-regression, and 3) meta-analysis using Mg variables categorized based on pre-existing recommendations. Three RCTs and 12 cohort studies were included in this systematic review. Evidence from the limited number of RCTs was insufficient to draw conclusions on the effects of Mg supplements. Cohort studies showed inconsistent dose–response relationships between dietary Mg and cognitive disorders, with high heterogeneity across populations. However, consistent U-shape associations of serum Mg with all-cause dementia and cognitive impairment were found in cohorts, suggesting an optimal serum Mg concentration of ∼0.85 mmol/L. This nonlinear association was detected in meta-regression (Pquadratic = 0.003) and in meta-analysis based on the reference interval of serum Mg (0.75–0.95 mmol/L) [<0.75 compared with 0.85 mmol/L: pooled hazard ratio (HR) = 1.43; 95% confidence interval (CI) = 1.05, 1.93; >0.95 compared with 0.85 mmol/L: pooled HR = 1.30; 95% CI = 1.03, 1.64]. More evidence from RCTs and cohorts is warranted. Future cohort studies should evaluate various Mg biomarkers and collect repeated measurements of Mg intake over time, considering different sources (diet or supplements) and factors affecting absorption (for example, calcium-to-Mg intake ratio). This systematic review was preregistered in PROSPERO (CRD42023423663).

镁(Mg)在神经功能和表现中起着关键作用。然而,关于镁与成人认知健康的随机对照试验(RCT)和队列研究的证据尚未得到系统回顾。我们旨在通过总结随机对照试验和队列研究的证据,研究各种形式的镁(补充剂、膳食摄入量和生物标志物)与认知结果之间的关系。我们在PubMed、Embase、PsycINFO和Cochrane对照试验中央注册中心检索了截至2024年5月3日发表的相关同行评审文章。在适当的情况下,采用了三种随机效应模型来评估镁与认知结果之间的关系:1)线性元回归;2)非线性(二次)元回归;3)使用根据已有建议分类的镁变量进行元分析。本系统综述纳入了 3 项研究性试验和 12 项队列研究。有限的研究性试验所提供的证据不足以就镁补充剂的效果得出结论。队列研究显示,膳食镁与认知障碍之间的剂量-反应关系不一致,不同人群之间的异质性很高。然而,在队列研究中发现,血清镁与全因痴呆症和认知障碍之间存在一致的 U 型关系,表明最佳血清镁浓度约为 0.85 mmol/L。在元回归(Pquadratic = 0.003)和基于血清镁参考区间(0.75-0.95 mmol/L)的元分析中发现了这种非线性关联[0.95 与 0.85 mmol/L:汇总 HR = 1.30;95% CI = 1.03,1.64]。我们需要更多来自 RCT 和队列研究的证据。未来的队列研究应评估各种镁生物标志物,并在考虑不同来源(饮食或补充剂)和影响吸收的因素(如钙镁摄入比)的情况下,收集一段时间内镁摄入量的重复测量值。本系统综述已在 PROSPERO(CRD42023423663)上预先注册。
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引用次数: 0
Is There Evidence to Support Probiotic Use for Healthy People? 有证据支持健康人使用益生菌吗?
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-01 DOI: 10.1016/j.advnut.2024.100265

Probiotics are typically marketed as foods and dietary supplements, categories for products intended to maintain health in generally healthy populations and which, unlike drugs, cannot claim to treat or cure disease. This review addresses the existing evidence that probiotics are beneficial to healthy people. Our approach was to perform a descriptive review of efficacy evidence that probiotics can prevent urinary, vaginal, gastrointestinal, and respiratory infections, and improve risk factors associated with cardiovascular health or reduce antibiotic use. Other endpoints such as mental, dental, or immune health were not specifically addressed. We concluded that there is sufficient evidence of efficacy and safety for clinicians and consumers to consider using specific probiotics for some indications – such as the use of probiotics to support gut function during antibiotic use or to reduce the risk of respiratory tract infections – for certain people. However, we did not find a sufficiently high level of evidence to support unconditional, population-wide recommendations for other preventive endpoints we reviewed for healthy people. Although evidence for some indications is suggestive of the preventive benefits of probiotics, additional research is needed.

益生菌通常作为食品和膳食补充剂在市场上销售,这两类产品的目的是维持一般健康人群的健康,与药物不同,它们不能声称能治疗或治愈疾病。本综述探讨了益生菌对健康人群有益的现有证据。我们的方法是对益生菌可以预防泌尿、阴道、胃肠道和呼吸道感染,改善心血管健康相关风险因素或减少抗生素使用的功效证据进行描述性综述。其他终点,如精神、牙齿或免疫健康,没有具体涉及。我们的结论是,有足够的有效性和安全性证据可供临床医生和消费者考虑在某些适应症中使用特定的益生菌,例如在某些人群使用抗生素期间使用益生菌支持肠道功能。但是,我们没有发现高水平的证据来支持我们针对健康人群审查的其他终点的建议。尽管某些适应症的证据表明益生菌具有预防性益处,但仍需进行更多研究。
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引用次数: 0
Analytic Methods for Understanding the Temporal Patterning of Dietary and 24-H Movement Behaviors: A Scoping Review 了解饮食和 24 小时运动行为时间模式的分析方法:范围综述。
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-01 DOI: 10.1016/j.advnut.2024.100275

Dietary and movement behaviors [physical activity (PA), sedentary behavior (SED), and sleep] occur throughout a 24-h day and involve multiple contexts. Understanding the temporal patterning of these 24-h behaviors and their contextual determinants is key to determining their combined effect on health. A scoping review was conducted to identify novel analytic methods for determining temporal behavior patterns and their contextual correlates. We searched Embase, ProQuest, and EBSCOhost databases in July 2022 to identify studies published between 1997 and 2022 on temporal patterns and their contextual correlates (e.g., locational, social, environmental, personal). We included 14 studies after title and abstract (n = 33,292) and full-text (n = 135) screening, of which 11 were published after 2018. Most studies (n = 4 in adults; n = 5 in children and adolescents), examined waking behavior patterns (i.e., both PA and SED) of which 3 also included sleep and 6 included contextual correlates. PA and diet were examined together in only 1 study of adults. Contextual correlates of dietary, PA, and sleep temporal behavior patterns were also examined. Machine learning with various clustering algorithms and model-based clustering techniques were most used to determine 24-h temporal behavior patterns. Although the included studies used a diverse range of methods, behavioral variables, and assessment periods, results showed that temporal patterns characterized by high SED and low PA were linked to poorer health outcomes, than those with low SED and high PA. This review identified temporal behavior patterns, and their contextual correlates, which were associated with adiposity and cardiometabolic disease risk, suggesting these methods hold promise for the discovery of holistic lifestyle exposures important to health. Standardized reporting of methods and patterns and multidisciplinary collaboration among nutrition, PA, and sleep researchers; statisticians; and computer scientists were identified as key pathways to advance future research on temporal behavior patterns in relation to health.

饮食和运动行为(体力活动 [PA]、久坐行为 [SED] 和睡眠)贯穿一天的 24 小时,涉及多种环境。了解这些 24 小时行为的时间模式及其环境决定因素是确定它们对健康的综合影响的关键。我们进行了一次范围综述,以确定用于确定时间行为模式及其环境相关因素的新型分析方法。我们检索了 Embase、ProQuest 和 EBSCOhost 数据库(2022 年 7 月),以确定 1997 年至 2022 年间发表的有关时间行为模式及其环境相关因素(如地点、社会、环境和个人)的研究。经过标题和摘要(n=33292)以及全文(n=135)筛选,我们纳入了14项研究,其中11项研究发表于2018年之后。大多数研究(4 项针对成人;5 项针对儿童和青少年)考察了清醒时的行为模式(即活动量和 SED),其中 3 项还包括睡眠,6 项包括环境相关因素。只有一项针对成人的研究同时研究了活动量和饮食。此外,还研究了饮食、PA 和睡眠时间行为模式的上下文相关性。使用各种聚类算法和基于模型的聚类技术的机器学习被广泛用于确定 24 小时的时间行为模式。虽然纳入的研究使用了各种方法、行为变量和评估时间段,但结果显示,与低 SED 和高 PA 的时间行为模式相比,高 SED 和低 PA 的时间行为模式与较差的健康结果有关。本综述确定了与脂肪和心血管代谢疾病风险相关的时间行为模式及其背景相关因素,这表明这些方法有望发现对健康有重要影响的整体生活方式。对方法和模式的标准化报告以及营养、体育锻炼和睡眠研究人员、统计学家和计算机科学家之间的多学科合作被认为是未来推进与健康有关的时间行为模式研究的关键途径。
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引用次数: 0
The Quality of Lunches Brought from Home to School: A Systematic Review and Meta-Analysis 从家里带到学校的午餐的质量:系统回顾和荟萃分析。
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-01 DOI: 10.1016/j.advnut.2024.100255

This systematic review and meta-analysis, spanning studies published between 1995 and 2021, investigates various aspects of lunches brought from home (LBFH) to school by children. These meals, in contrast to those provided by the National School Lunch Program (NSLP), lack strict nutritional standards. Despite the availability of NSLP lunches, ∼40% of US children opt for LBFH. This review aims to assess the food content and nutritional quality of LBFH, their adherence to NSLP standards in terms of nutrition and cost, effectiveness of intervention programs designed to enhance their nutritional quality and parental and student perceptions of LBFH. The comprehensive literature search yielded 28 eligible papers, with 16 included in meta-analysis. LBFH commonly include fruits (50%), yet vegetables (17%) and dairy (25%) are less prevalent. They frequently contain snacks (50%), sweets (48%), and sugar-sweetened beverages (31%). Compared with school lunches, LBFH exhibit lower levels of calcium, protein, iron, fiber, and vitamin A, and higher levels of carbohydrates and saturated fat. Intervention programs had no effect on quality of LBFH. On average, LBFH ($1.81) cost slightly less than lunches served at school ($1.98), without accounting for free/reduced-price meals in the calculation. The cost of school lunch for pre-k and kindergarten children became $11.32, nearly 4 times higher than that of LBFH ($2.92), after replicating the meal at home and accounting for meal preparation time. Parents preferred LBFH over school lunches because of concerns related to the quality of school meals served. This study concludes that LBFH are generally less nutritious compared with lunches provided by NSLP. Future research needs to further explore ways to improve parent perception of NSLP. Especially with many states making free meals available to all children, identifying effective ways in promoting and increasing NSLP participation can ensure more children have access to nutritionally balanced and affordable lunches.

本系统综述和荟萃分析涵盖 1995 年至 2021 年间发表的研究,调查了儿童从家中带到学校的午餐(LBFH)的各个方面。这些午餐与国家学校午餐计划(NSLP)提供的午餐不同,没有严格的营养标准。尽管有 NSLP 午餐,但仍有约 40% 的美国儿童选择 LBFH。本综述旨在评估 LBFH 的食物含量和营养质量、其在营养和成本方面是否符合 NSLP 标准、旨在提高其营养质量的干预计划的有效性以及家长和学生对 LBFH 的看法。通过全面的文献检索获得了 28 篇符合条件的论文,其中 16 篇被纳入荟萃分析。枸杞早餐通常包括水果(50%),但蔬菜(17%)和奶制品(25%)较少。它们经常包含零食(50%)、甜食(48%)和含糖饮料(31%)。与学校午餐相比,LBFH 的钙、蛋白质、铁、纤维素和维生素 A 含量较低,碳水化合物和饱和脂肪含量较高。干预计划对枸杞早餐的质量没有影响。在不考虑免费/减价餐的情况下,枸杞家庭餐的平均成本(1.81 美元)略低于学校午餐(1.98 美元)。学前班和幼儿园儿童在学校午餐的费用为 11.32 美元,比 LBFH 的费用(2.92 美元)高出近四倍。由于对学校膳食质量的担忧,家长们更倾向于选择浐灞家庭式午餐,而不是学校午餐。本研究的结论是,与 "国家学生补充计划"(NSLP)提供的午餐相比,"低脂家庭餐 "的营养成分普遍较低。未来的研究需要进一步探讨如何改善家长对 NSLP 的看法。特别是在许多州向所有儿童提供免费餐的情况下,确定有效的方法来促进和提高 NSLP 的参与度,可以确保更多的儿童获得营养均衡且价格合理的午餐。
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引用次数: 0
Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis 抗氧化剂与卵巢衰老妇女的生育能力:系统回顾与元分析》(Antioxidants and Fertility in Women with Ovarian Ageing: a Systematic Review and Meta-Analysis)。
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-01 DOI: 10.1016/j.advnut.2024.100273

Ovarian aging is a major factor for female subfertility. Multiple antioxidants have been applied in different clinical scenarios, but their effects on fertility in women with ovarian aging are still unclear. To address this, a meta-analysis was performed to evaluate the effectiveness and safety of antioxidants on fertility in women with ovarian aging. A total of 20 randomized clinical trials with 2617 participants were included. The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to higher clinical pregnancy rates. According to the subgroup analysis of different dose settings, better effects were more pronounced with lower doses; in terms of antioxidant types, coenzyme Q10 (CoQ10) tended to be more effective than melatonin, myo-inositol, and vitamins. When compared with placebo or no treatment, CoQ10 showed more advantages, whereas small improvements were observed with other drugs. In addition, based on subgroup analysis of CoQ10, the optimal treatment regimen of CoQ10 for improving pregnancy rate was 30 mg/d for 3 mo before the controlled ovarian stimulation cycle, and women with diminished ovarian reserve clearly benefited from CoQ10 treatment, especially those aged <35 y. Our study suggests that antioxidant consumption is an effective and safe complementary therapy for women with ovarian aging. Appropriate antioxidant treatment should be offered at a low dose according to the patient’s age and ovarian reserve.

This study was registered at PROSPERO as CRD42022359529.

卵巢衰老是导致女性不孕的一个主要因素。多种抗氧化剂已被应用于不同的临床情况,但它们对卵巢衰老女性生育力的影响仍不明确。为此,我们进行了一项荟萃分析,以评估抗氧化剂对卵巢衰老女性生育的有效性和安全性。该研究共纳入了20项随机临床试验(RCT),共有2617人参与。结果表明,使用抗氧化剂不仅能显著增加取回的卵母细胞数量和优质胚胎率,还能减少促性腺激素的剂量,从而提高临床妊娠率。根据亚组分析,就不同剂量设置而言,低剂量效果更明显;就抗氧化剂类型而言,辅酶Q10(CoQ10)往往比褪黑素、肌醇和维生素更有效,因为与安慰剂或不治疗相比,辅酶Q10显示出更大优势,而其他药物则改善甚微。此外,根据辅酶Q10的亚组分析,辅酶Q10提高妊娠率的最佳治疗方案是在控制性卵巢刺激周期前三个月,每天30毫克,卵巢储备功能减退的妇女明显受益于辅酶Q10治疗,尤其是35岁以下的妇女。我们的研究表明,对于卵巢衰老的妇女来说,抗氧化剂是一种有效而安全的辅助疗法。应根据患者的年龄和卵巢储备功能,从低剂量开始提供适当的抗氧化剂治疗。本研究已在 PROSPERO 注册(CRD42022359529)。
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引用次数: 0
We Are What, When, And How We Eat: The Evolutionary Impact of Dietary Shifts on Physical and Cognitive Development, Health, and Disease 我们吃什么、什么时候吃、怎么吃:饮食变化对身体和认知发展、健康和疾病的进化影响。
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-25 DOI: 10.1016/j.advnut.2024.100280

“We are what, when, and how we eat”: the evolution of human dietary habits mirrors the evolution of humans themselves. Key developments in human history, such as the advent of stone tool technology, the shift to a meat-based diet, control of fire, advancements in cooking and fermentation techniques, and the domestication of plants and animals, have significantly influenced human anatomical, physiological, social, cognitive, and behavioral changes. Advancements in scientific methods, such as the analysis of microfossils like starch granules, plant-derived phytoliths, and coprolites, have yielded unprecedented insights into past diets. Nonetheless, the isolation of ancient food matrices remains analytically challenging. Future technological breakthroughs and a more comprehensive integration of paleogenomics, paleoproteomics, paleoglycomics, and paleometabolomics will enable a more nuanced understanding of early human ancestors’ diets, which holds the potential to guide contemporary dietary recommendations and tackle modern health challenges, with far-reaching implications for human well-being, and ecological impact on the planet.

"我们吃什么、什么时候吃、怎么吃":人类饮食习惯的演变反映了人类自身的演变。人类历史上的重要发展,如石器技术的出现、向肉食饮食的转变、对火的控制、烹饪和发酵技术的进步、动植物的驯化等,都对人类的解剖、生理、社会、认知和行为变化产生了重大影响。科学方法的进步,如对淀粉颗粒、植物衍生的植金石和桡骨岩等微化石的分析,为人们了解过去的饮食提供了前所未有的视角。然而,古代食物基质的分离在分析上仍然具有挑战性。未来的技术突破以及古基因组学、古蛋白质组学、古地层组学和古代谢组学的更全面整合将使人们能够更细致地了解人类早期祖先的饮食,从而有可能指导当代饮食建议和应对现代健康挑战,对人类福祉和地球生态影响产生深远影响。
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引用次数: 0
Disrupted prenatal metabolism may explain the etiology of suboptimal neurodevelopment: a focus on phthalates and micronutrients and their relationship to autism spectrum disorder 产前代谢紊乱可解释神经发育不良的病因:聚焦邻苯二甲酸盐和微量营养素及其与自闭症谱系障碍的关系。
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-24 DOI: 10.1016/j.advnut.2024.100279

Pregnancy is a time of high metabolic coordination, as maternal metabolism adapts to support the growing fetus. Many of these changes are coordinated by the placenta, a critical fetal endocrine organ and the site of maternal–fetal crosstalk. Dysregulation in maternal and placental metabolism during pregnancy has been linked to adverse outcomes, including altered neurodevelopment. Autism spectrum disorder (ASD) is a neurodevelopmental disorder linked to metabolic alterations in both children and their mothers. Prenatal environmental exposures have been linked to risk of ASD through dysregulated maternal, placental, and fetal metabolism. In this review, we focus on recent studies investigating the associations between prenatal metabolism in the maternal-placental-fetal unit and the impact of prenatal environmental exposures to phthalates and micronutrients on ASD risk. By identifying the mechanisms through which phthalates and other ubiquitous endocrine disrupting chemicals influence development, and how nutritional interventions can impact those mechanisms, we can identify promising ways to prevent suboptimal neurodevelopment.

孕期是新陈代谢高度协调的时期,因为母体的新陈代谢要适应胎儿的生长发育。胎盘是胎儿的重要内分泌器官,也是母体与胎儿之间相互影响的部位。孕期母体和胎盘代谢失调与不良后果有关,包括神经发育的改变。自闭症谱系障碍(ASD)是一种神经发育障碍,与儿童及其母亲的新陈代谢改变有关。通过母体、胎盘和胎儿代谢失调,产前环境暴露与自闭症风险有关。在这篇综述中,我们将重点讨论最近的一些研究,这些研究调查了母体-胎盘-胎儿单元中产前代谢之间的关联,以及产前环境暴露于邻苯二甲酸盐和微量营养素对 ASD 风险的影响。通过确定邻苯二甲酸盐和其他无处不在的干扰内分泌的化学物质对发育的影响机制,以及营养干预措施如何影响这些机制,我们可以找出预防神经发育不良的有效方法。
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引用次数: 0
Health Effects of Various Edible Vegetable Oil: An Umbrella Review 各种食用植物油对健康的影响:综述。
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-23 DOI: 10.1016/j.advnut.2024.100276

Vegetable oils, derived from diverse sources such as seeds, nuts, and some fruits, play a significant role in dietary health. However, the current evidence on the health effects of different types of vegetable oil consumption remains controversial. This umbrella review aims to synthesize evidence from systematic reviews and meta-analyses to assess the health outcomes associated with various vegetable oils. A comprehensive literature search was performed up to 31 July, 2023 on 12 databases for studies examining the association of different vegetable oils with health outcomes in adults. Data was extracted independently by 2 authors, with evidence strength assessed using the grading of recommendations, assessment, development, and evaluation criteria. A total of 48 studies, including 206 meta-analyses, were included. Moderate to very low certainty evidence showed that monounsaturated and polyunsaturated fatty acids such as canola oil, virgin olive oil, and rice bran oil are beneficial in reducing serum total cholesterol and low-density lipoprotein (LDL) concentrations. Conversely, low to very low certainty evidence suggests that oils high in saturated fats, such as coconut oil and palm oil, increase total cholesterol and LDL concentrations but also raise high-density lipoprotein concentrations. Very low certainty evidence showed the consumption of olive oil, sesame oil, and coconut oil could improve blood sugar control. Low certainty evidence showed olive oil consumption reduced risk of breast, digestive, and other cancers. Moderate to very low certainty evidence suggested that canola oil and sesame oil consumption reduced body weight. The consumption of vegetable oil appears to offer different health benefits, with summary estimates indicating beneficial effects on reducing lipid concentrations, especially with monounsaturated and polyunsaturated rich oils when consumed in recommended amounts. Future research should focus on long-term studies and comprehensive dietary assessments to better understand the health impacts of vegetable oils, providing a basis for informed dietary recommendations.

This study was registered at PROSPERO as CRD42021239210.

植物油的来源多种多样,如种子、坚果和一些水果,它们在膳食健康中发挥着重要作用。然而,目前有关食用不同类型植物油对健康影响的证据仍存在争议。本综述旨在综合来自系统综述和荟萃分析的证据,以评估各种植物油对健康的影响。截至 2023 年 7 月 31 日,我们在 12 个数据库中进行了全面的文献检索,以了解有关不同植物油与成人健康结果相关性的研究。数据由两位作者独立提取,并采用 GRADE 标准评估证据强度。共纳入了 48 项研究,包括 206 项元分析。中度到极低确定性证据显示,菜籽油、初榨橄榄油和米糠油等单不饱和脂肪酸和多不饱和脂肪酸有益于降低血清总胆固醇和低密度脂蛋白水平。相反,低度到极低度确定性证据表明,椰子油和棕榈油等饱和脂肪含量高的油类会增加总胆固醇和低密度脂蛋白水平,但也会提高高密度脂蛋白水平。极低确定性证据显示,食用橄榄油、芝麻油和椰子油可改善血糖控制。低确定性证据显示,食用橄榄油可降低罹患乳腺癌、消化系统癌症和其他癌症的风险。中度至极度不确定的证据表明,食用菜籽油和芝麻油可减轻体重。食用植物油似乎能带来不同的健康益处,汇总估算结果表明,食用推荐量的植物油,尤其是富含单不饱和和多不饱和脂肪酸的植物油,对降低血脂水平有益。未来的研究应侧重于长期研究和全面膳食评估,以更好地了解植物油对健康的影响,为知情的膳食建议提供依据。系统综述注册:prospero crd42021239210。
{"title":"Health Effects of Various Edible Vegetable Oil: An Umbrella Review","authors":"","doi":"10.1016/j.advnut.2024.100276","DOIUrl":"10.1016/j.advnut.2024.100276","url":null,"abstract":"<div><p>Vegetable oils, derived from diverse sources such as seeds, nuts, and some fruits, play a significant role in dietary health. However, the current evidence on the health effects of different types of vegetable oil consumption remains controversial. This umbrella review aims to synthesize evidence from systematic reviews and meta-analyses to assess the health outcomes associated with various vegetable oils. A comprehensive literature search was performed up to 31 July, 2023 on 12 databases for studies examining the association of different vegetable oils with health outcomes in adults. Data was extracted independently by 2 authors, with evidence strength assessed using the grading of recommendations, assessment, development, and evaluation criteria. A total of 48 studies, including 206 meta-analyses, were included. Moderate to very low certainty evidence showed that monounsaturated and polyunsaturated fatty acids such as canola oil, virgin olive oil, and rice bran oil are beneficial in reducing serum total cholesterol and low-density lipoprotein (LDL) concentrations. Conversely, low to very low certainty evidence suggests that oils high in saturated fats, such as coconut oil and palm oil, increase total cholesterol and LDL concentrations but also raise high-density lipoprotein concentrations. Very low certainty evidence showed the consumption of olive oil, sesame oil, and coconut oil could improve blood sugar control. Low certainty evidence showed olive oil consumption reduced risk of breast, digestive, and other cancers. Moderate to very low certainty evidence suggested that canola oil and sesame oil consumption reduced body weight. The consumption of vegetable oil appears to offer different health benefits, with summary estimates indicating beneficial effects on reducing lipid concentrations, especially with monounsaturated and polyunsaturated rich oils when consumed in recommended amounts. Future research should focus on long-term studies and comprehensive dietary assessments to better understand the health impacts of vegetable oils, providing a basis for informed dietary recommendations.</p><p>This study was registered at PROSPERO as CRD42021239210.</p></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2161831324001108/pdfft?md5=7af69449e4d29ded11e320bf1fd97022&pid=1-s2.0-S2161831324001108-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Modulation of Host Defense Peptide Synthesis: A Novel Host-Directed Antimicrobial Therapeutic Strategy? 营养调节宿主防御肽的合成:宿主导向的新型抗菌治疗策略?
IF 8 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-07-23 DOI: 10.1016/j.advnut.2024.100277

The escalating threat of antimicrobial resistance underscores the imperative for innovative therapeutic strategies. Host defense peptides (HDPs), integral components of innate immunity, exhibit profound antimicrobial and immunomodulatory properties. Various dietary compounds, such as short-chain fatty acids, vitamins, minerals, sugars, amino acids, phytochemicals, bile acids, probiotics, and prebiotics have been identified to enhance the synthesis of endogenous HDPs without provoking inflammatory response or compromising barrier integrity. Additionally, different classes of these compounds synergize in augmenting HDP synthesis and disease resistance. Moreover, dietary supplementation of several HDP-inducing compounds or their combinations have demonstrated robust protection in rodents, rabbits, pigs, cattle, and chickens from experimental infections. However, the efficacy of these compounds in inducing HDP synthesis varies considerably among distinct compounds. Additionally, the regulation of HDP genes occurs in a gene-specific, cell type–specific, and species-specific manner. In this comprehensive review, we systematically summarized the modulation of HDP synthesis and the mechanism of action attributed to each major class of dietary compounds, including their synergistic combinations, across a spectrum of animal species including humans. We argue that the ability to enhance innate immunity and barrier function without triggering inflammation or microbial resistance positions the nutritional modulation of endogenous HDP synthesis as a promising host-directed approach for mitigating infectious diseases and antimicrobial resistance. These HDP-inducing compounds, particularly in combinations, harbor substantial clinical potential for further exploration in antimicrobial therapies for both human and other animals.

抗菌药耐药性的威胁不断升级,这凸显了创新治疗策略的必要性。宿主防御肽(HDPs)是先天性免疫不可或缺的组成部分,具有深远的抗菌和免疫调节特性。目前已发现短链脂肪酸、维生素、矿物质、糖类、氨基酸、植物化学物质、胆汁酸、益生菌和益生元等各种膳食化合物可增强内源性 HDPs 的合成,而不会引起炎症反应或损害屏障的完整性。此外,这些化合物的不同类别在增强 HDP 合成和抗病能力方面具有协同作用。此外,膳食中补充几种 HDP 诱导化合物或其组合已在动物实验感染中显示出强大的保护作用。然而,这些化合物在诱导 HDP 合成方面的功效在不同化合物之间存在很大差异。此外,HDP 基因的调控是以基因、细胞类型和物种特异性的方式进行的。在这篇综述中,我们系统地总结了包括人类在内的各种动物物种对 HDP 合成的调节作用以及每一类主要膳食化合物(包括它们的协同组合)的作用机制。我们认为,营养调节内源性 HDP 合成能够增强先天免疫力和屏障功能,而不会引发炎症或微生物抗药性,因此是减轻传染病和抗微生物抗药性的一种很有前景的宿主导向方法。这些诱导 HDP 的化合物,尤其是其组合,具有巨大的临床潜力,可在人类和其他动物的抗菌疗法中进一步探索。
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引用次数: 0
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Advances in Nutrition
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