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Food Biodiversity and its Association with Diet Quality and Health Outcomes-A Scoping Review 食物生物多样性及其与饮食质量和健康结果的关系——一项范围综述。
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-11-01 DOI: 10.1016/j.advnut.2025.100551
Jinke H Baan Hofman , Celia Bannenberg Cavero , Mariska Dötsch-Klerk , Anne J Wanders , Corné van Dooren , Edith JM Feskens , Baukje de Roos , Sander Biesbroek
Food biodiversity is receiving increased attention because of global food systems being a major contributor to biodiversity loss. Food biodiversity, defined as the diversity of plants, animals, and other organisms used for food, may benefit both human and planetary health. Despite this potential, little is known about the association between food biodiversity and the healthiness of human diets. This systematic scoping review presents an overview of the nexus between food biodiversity, diet quality, health outcomes, and environmental impact. Three search strategies were performed in Scopus and PubMed Central, to identify English articles published up until December 2024 on food biodiversity in relation to diet quality, health outcomes, and environmental impact. Eight studies reported on the association between food biodiversity and diet quality, and 4 on the association between food biodiversity and health outcomes. No studies reported on the association between food biodiversity and environmental impact. The studies quantified food biodiversity using Nutritional Functional Diversity, Dietary Species Richness (DSR), Simpson Diversity Index, Shannon Diversity Index, Berger-Parker Index, or a combination of these. One study compared the latter 4 metrics by calculating Hill numbers. Despite using different metrics, all studies showed significant positive associations between food biodiversity and nutritional adequacy, a reduced risk of total and cause-specific mortality, or a reduced risk of gastrointestinal cancers. One study reported a nonsignificant association between DSR and body fat percentage. In conclusion, limited available studies consistently find a positive association between food biodiversity, diet quality, and decreased health risks, highlighting the potential of food biodiversity to improve the healthiness of diets. Currently, DSR is proposed to be the most feasible metric to quantify food biodiversity. Future studies should focus on the added value of food biodiversity over dietary diversity in relation to human and planetary health, which is currently unclear.
由于全球粮食系统是生物多样性丧失的主要原因,粮食生物多样性正受到越来越多的关注。粮食生物多样性的定义是用于粮食的植物、动物和其他生物的多样性,它可能有益于人类和地球的健康。尽管有这种潜力,但人们对食物生物多样性与人类饮食健康之间的关系知之甚少。这篇系统的范围综述综述了食物生物多样性、饮食质量、健康结果和环境影响之间的关系。在Scopus和PubMed Central中执行了三种搜索策略,以确定截至2024年12月发表的关于食物生物多样性与饮食质量、健康结果和环境影响相关的英文文章。8项研究报告了食物生物多样性与饮食质量之间的关系,4项研究报告了食物生物多样性与健康结果之间的关系。没有关于粮食生物多样性与环境影响之间关系的研究报道。研究采用营养功能多样性(NFD)、膳食物种丰富度(DSR)、Simpson多样性指数(SDI)、Shannon多样性指数(SHDI)、Berger-Parker指数(BP)或以上几种指数的组合对食物多样性进行量化。一项研究通过计算希尔数来比较后四种指标。尽管使用了不同的衡量标准,但所有研究都表明,食物生物多样性与营养充足性、总死亡率和原因特异性死亡率风险降低或胃肠道癌症风险降低之间存在显著的正相关。一项研究报告DSR和体脂率之间无显著关联。总之,有限的现有研究一致发现食物生物多样性、饮食质量和降低健康风险之间存在正相关关系,突出了食物生物多样性在改善饮食健康方面的潜力。目前,DSR被认为是量化粮食生物多样性最可行的指标。未来的研究应侧重于食物生物多样性对人类和地球健康的附加价值,这一点目前尚不清楚。
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引用次数: 0
Plant-Based Diets and Cognitive Outcomes: A Systematic Review and Meta-analysis 植物性饮食和认知结果:系统回顾和荟萃分析。
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-11-01 DOI: 10.1016/j.advnut.2025.100537
Catherine Bigras , Riccardo Mazzoli , Danielle Laurin , Marcella Malavolti , Giulia Barbolini , Marco Vinceti , Jean-Philippe Drouin-Chartier , Tommaso Filippini
Although plant-rich dietary patterns like the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diets have been linked to cognitive benefits, the role of predominantly plant-based diets is less understood. This systematic review aimed to evaluate the association between plant-based diets and cognitive outcomes. A literature search was conducted in Medline and Embase using keywords related to plant-based diets (e.g., “vegetarian diet”) and cognitive outcomes (e.g., “dementia”). Studies of any design were eligible. Reviewers independently screened studies, extracted data, and assessed quality using the Newcastle-Ottawa Scale. Meta-analyses were conducted on prospective studies that examined the same dietary exposure and cognitive outcome, using fixed-effects regression models. Twenty-two studies were included, with considerable variability in methodologies and outcomes. Plant-based diets were defined either categorically (e.g., vegetarian compared with nonvegetarian), or using indices of adherence, such as the healthful plant-based diet index (hPDI), with higher scores reflecting higher adherence. Two meta-analyses, each based on 2 high-quality prospective cohort studies, examined associations between plant-based diet indices and cognitive outcomes. For cognitive impairment, pooled odds ratios (95% confidence interval) for highest compared with lowest quartiles were 0.61 (0.55, 0.68; I2 = 97.1%) for plant-based diet index (PDI) and 0.68 (0.62, 0.75; I2 = 84.3%) for hPDI. For dementia, pooled hazard ratios were 1.03 (0.91, 1.17; I2 = 0%) for PDI, 0.85 (0.75, 0.97; I2 = 0%) for hPDI, and 1.17 (1.03, 1.33; I2 = 60.3%) for unhealthful PDI. These findings suggest that dietary patterns emphasizing healthful plant-based foods and limiting less healthful plant foods and animal products are associated with lower odds of cognitive impairment and risk of dementia. However, findings across individual studies were inconsistent, highlighting the need for further high-quality research.
This review was registered at PROSPERO as CRD42022380055.
虽然像地中海饮食和MIND饮食这样富含植物的饮食模式与认知益处有关,但主要以植物为基础的饮食的作用却鲜为人知。本系统综述旨在评估植物性饮食与认知结果之间的关系。方法:在Medline和Embase中使用与植物性饮食相关的关键词进行文献检索。“素食”)和认知结果(例如:“痴呆”)。任何设计的研究都是合格的。审稿人独立筛选研究,提取数据,并使用纽卡斯尔-渥太华量表评估质量。使用固定效应回归模型对前瞻性研究进行了荟萃分析,这些研究检查了相同的饮食暴露和认知结果。结果:纳入了22项研究,在方法和结果上有相当大的差异。植物性饮食要么被分类定义(例如,素食者与非素食者),要么使用坚持指标,如健康植物性饮食指数(hPDI),得分越高,坚持程度越高。两项荟萃分析均基于两项高质量的前瞻性队列研究,研究了植物性饮食指数与认知结果之间的关系。对于认知障碍,PDI最高四分位数与最低四分位数的合并or (95% CI)为0.61 (0.55,0.68;I2=97.1%), hPDI为0.68 (0.62,0.75;I2=84.3%)。对于痴呆症,PDI的合并hr为1.03 (0.91,1.17;I2=0%), hPDI的合并hr为0.85 (0.75,0.97;I2=0%),不健康PDI (uPDI)的合并hr为1.17 (1.03,1.33;I2=60.3%)。结论:这些发现表明,强调健康的植物性食物和限制不健康的植物性食物和动物产品的饮食模式与认知障碍和痴呆风险较低相关。然而,个别研究的结果不一致,强调需要进一步的高质量研究。
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引用次数: 0
Efficacy of Iron-Rich Snacks in Improving Iron Status Among Adolescent Girls (10‒19 Years): A Systematic Review 富铁零食改善青春期女孩(10 - 19岁)铁状态的功效:一项系统综述。
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-10-29 DOI: 10.1016/j.advnut.2025.100549
Hope Masanja , Haikael D Martin , Theresia Jumbe , Wanjiku N Gichohi-Wainaina
Iron deficiency anaemia (IDA) is the most common form of anaemia and the leading cause of years lived with disabilities (YLD) and disability-adjusted life years (DALYs) among adolescents. Recently, various iron-rich snacks have been developed as interventions to improve iron status among adolescents. This review aimed to evaluate the efficacy of natural, non-commercially fortified iron-rich snacks in improving iron status among adolescent girls aged 10–19 years. A systematic review of randomized controlled trials and quasi-experiments was conducted, focusing on iron status indicators including hemoglobin (Hb), serum ferritin (SF), transferrin saturation (TSAT), and soluble transferrin receptors (sTfR). Searches were performed in PubMed, ScienceDirect, EBSCO, Research4Life, and Google Scholar. Risk of bias was assessed using Cochrane tools, and study quality was evaluated with GRADE. Ten studies (five RCTs and five quasi-experiments) involving 24 to 211 participants were included. Nine studies had moderate risk of bias, mainly due to performance, detection, and reporting issues; one had high selection bias. Iron content of snacks varied, with nine studies out of ten reported Hb increases ranging from 0.45 to 2.28 g/dL. Only one study reported improvements in serum iron (from 25.482 ± 0.036 g/dL to 41.511 ± 0.033 g/dL) and ferritin (from 10.827 ± 0.192 ng/mL to 14.016 ± 0.103 ng/mL). These results indicate the potential of locally developed snacks to improve iron and Hb levels in adolescents. This review synthesizes evidence on food-based interventions, focusing on natural, non-fortified iron-rich snacks for adolescent girls. The findings demonstrate promising potential for these snacks to improve iron status and haemoglobin concentrations, underscoring their value as culturally acceptable, cost-effective, and sustainable complement to existing nutrition strategies. Although results are promising, more rigorously designed trials with comprehensive iron biomarkers are needed to confirm efficacy and support integration into adolescent nutrition programs.
背景:缺铁性贫血(IDA)是最常见的贫血形式,也是青少年残疾生活年数(YLD)和残疾调整生命年数(DALYs)的主要原因。最近,各种富含铁的零食被开发出来作为改善青少年铁状况的干预措施。目的:本综述旨在评价天然、非商业强化的富含铁的零食在改善10-19岁少女铁状况方面的功效。方法:系统回顾随机对照试验和准实验,重点关注血红蛋白(Hb)、血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)和可溶性转铁蛋白受体(sTfR)等铁状态指标。在PubMed, ScienceDirect, EBSCO, Research4Life和b谷歌Scholar中进行了搜索。使用Cochrane工具评估偏倚风险,使用GRADE评估研究质量。结果:共纳入10项研究(5项随机对照试验和5项准实验),涉及24 ~ 211名受试者。9项研究有中等偏倚风险,主要是由于表现、检测和报告问题;其中一个有很高的选择偏差。零食的铁含量各不相同,十项研究中有九项报告Hb增加范围为0.45至2.28 g/dL。只有一项研究报告了血清铁(从25.482±0.036 g/dL到41.511±0.033 g/dL)和铁蛋白(从10.827±0.192 ng/mL到14.016±0.103 ng/mL)的改善。这些结果表明,当地开发的零食有可能改善青少年的铁和血红蛋白水平。结论:本综述综合了基于食物的干预措施的证据,重点关注青春期女孩的天然、非强化富含铁的零食。研究结果表明,这些零食有改善铁状态和血红蛋白浓度的潜力,强调了它们作为文化上可接受的、具有成本效益的、可持续的补充现有营养策略的价值。虽然结果是有希望的,但需要更严格设计的综合铁生物标志物试验来证实其功效,并支持将其纳入青少年营养计划。注册:该综述方案已在国际前瞻性系统评价注册(PROSPERO)数据库注册(CRD42023404052)。
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引用次数: 0
Public Health Impacts of Water Fluorides: Current Evidence from a Rapid Systematic Review 水氟化物对公共卫生的影响:来自快速系统审查的当前证据。
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-10-22 DOI: 10.1016/j.advnut.2025.100547
Fatemeh V Zohoori , Elizabeth A Kumah , Jelena Kronic , Michael Drinnan , Alexander J Morris
Despite being established public health practice for >80 y, community water fluoridation continues to attract assertions of harm, and continued scrutiny of the evidence is required to inform policy. A rapid systematic literature review was conducted to examine human nondental health outcomes from fluoride exposure through drinking water. A protocol was developed a priori and registered on the Open Science Framework. Literature searches were conducted in Medline, CINAHL, Web of Science, Embase, PubMed, Campbell Collaboration, Cochrane Library, and Scopus databases. Gray literature and citation searches were also undertaken. Quality assessment was performed using the Mixed Methods Appraisal Tool (MMAT). Meta-analysis was judged not feasible due to the heterogeneous nature of the included studies. A total of 1143 unique records were identified, of which 130 full-text studies were reviewed and 58 were selected for final inclusion. Among these, 37 were cross-sectional studies, 15 were cohort studies, 4 were case-control studies, and 2 were ecological studies. Most studies were judged to be of acceptable quality using MMAT. The most common risk of bias was insufficient control of confounders. Health outcomes studied included blood pressure, neurological outcomes, bone cancers, thyroid function, skeletal outcomes, low birth weight/preterm birth, and metabolic outcomes. In children, some evidence of adverse effects on neurological outcomes and thyroid function was observed. In adults, some evidence was identified of adverse effects on blood pressure, thyroid function, and skeletal structure. In general, these effects occurred at drinking water fluoride concentrations >1.5 mg/L. No evidence of adverse effects was found at concentrations <1.0 mg/L in both children and adults. The nature of study designs and methodological limitations precluded causal inference. No convincing evidence of harm was identified from community water fluoridation at concentrations between 0.7 and 1.0 mg/L, whereas uncertainty remains at higher concentrations. Significant methodological limitations highlight the need for more rigorous future studies. A protocol was developed a priori and registered on the Open Science Framework (Registration DOI: https://doi.org/10.17605/OSF.IO/JH245).
导言:尽管社区饮水氟化作为一种公共卫生做法已有80多年的历史,但它仍在不断吸引有关危害的断言,需要对证据进行持续审查,以便为政策提供信息。方法:对通过饮用水接触氟化物对人类非牙齿健康的影响进行了快速系统的文献综述。事先制定了一项协议,并在开放科学框架上注册。在Medline、CINAHL、Web of Science、Embase、PubMed、Campbell Collaboration、Cochrane Library和Scopus数据库中进行文献检索。还进行了灰色文献和引文检索。采用混合方法评价工具(MMAT)进行质量评价。由于纳入研究的异质性,meta分析被认为是不可行的。结果:共鉴定出1143份独特的记录,其中130份全文研究被审查,58份被最终纳入。其中横断面研究37项,队列研究15项,病例对照研究4项,生态学研究2项。使用MMAT来判断大多数研究的质量是可接受的。最常见的偏倚风险是对混杂因素的控制不足。研究的健康结果包括血压、神经系统结果、骨癌、甲状腺功能、骨骼结果、低出生体重/早产和代谢结果。在儿童中,发现了一些对神经预后和甲状腺功能有不良影响的证据。在成人中,一些证据表明对血压、甲状腺功能和骨骼结果有不良影响。一般来说,这些影响发生在饮用水氟化物浓度超过1.5毫克/升时。在儿童和成人中,浓度低于1.0mg/L均未发现不良反应的证据。研究设计的性质和方法的局限性排除了因果推理。结论:没有令人信服的证据表明,浓度在0.7至1.0mg/L之间的社区水氟化会造成危害,而浓度较高的社区水氟化仍存在不确定性。重大的方法学局限性突出表明需要进行更严格的未来研究。系统评价或荟萃分析的登记和登记编号:先验地制定了一项方案,并在开放科学框架(注册DOI: https://doi.org/10.17605/OSF.IO/JH245).Statement)上注册。重要意义:这项快速系统评价提供了2009年后关于饮用水中氟化物暴露对人类非牙齿健康后果的最新综合证据。报告没有发现在建议的氟化水平(0.7-1.0毫克/升)下存在危害的令人信服的证据,并确定了现有研究的主要方法学局限性,这些局限性应指导未来的研究和政策讨论。
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引用次数: 0
Tea Polyphenol Epigallocatechin Gallate and the Gut–Health Axis: Unraveling Structural Characteristics, Metabolic Pathways, and Systemic Benefits 茶多酚EGCG和肠道健康轴:揭示结构特征、代谢途径和全身益处。
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-10-15 DOI: 10.1016/j.advnut.2025.100545
Jiaying Yang, Wei Chen, Jiayi Chen, Dengchao Xie, Yuefei Wang, Jihong Zhou
Dietary components significantly impact human health, influencing diverse physiological processes from metabolic homeostasis to cognitive function and aging. Tea, a widely consumed functional beverage rich in antioxidants, has gained attention for its health benefits. Epigallocatechin gallate (EGCG), the most abundant and bioactive catechin in green tea, is renowned for its potent biological activities. However, the direct absorption of EGCG is limited due to its low oral bioavailability, with a substantial portion reaching the colon where it interacts extensively with gut microbiota. This microbial interplay is crucial for EGCG’s biotransformation and the realization of its health-promoting potential, yet the underlying mechanisms remain to be fully elucidated. This review synthesizes EGCG's structural features, metabolism, and interactions with gut microbiota, summarizing its roles in gut health and systemic effects through gut-related axes, and outlines future research. First, it elaborates EGCG's structural features, as a flavan-3-ol with a polyphenolic structure containing multiple hydroxyl groups, whose antioxidant and bioactive properties are associated with the specific arrangement of benzene rings and the gallate moiety. Second, it outlines its metabolic process, limited absorption in the small intestine, enzymatic metabolism in the small intestine and liver (including methylation, glucuronidation, and sulfation), and extensive biotransformation in the colon by gut microbiota into metabolites such as epigallocatechin and gallic acid. Third, it explores its effects on the gut, modulating gut microbiota composition by promoting beneficial bacteria and inhibiting pathogenic strains, enhancing intestinal barrier function by upregulating tight junction proteins, and promoting the production of short-chain fatty acids. Finally, it elucidates how EGCG modulates key gut-related health pathways and its broader implications for systemic health through various interconnected gut axes, including the gut–liver, gut–brain, gut–renal, and gut–lung axes, and concludes by outlining prospective research directions aimed at further elucidating the potential of EGCG in promoting health.
饮食成分显著影响人体健康,影响从代谢稳态到认知功能和衰老的多种生理过程。茶是一种广泛消费的富含抗氧化剂的功能性饮料,因其对健康的益处而受到关注。表没食子儿茶素没食子酸酯(EGCG)是绿茶中含量最多、最具生物活性的儿茶素,以其强大的生物活性而闻名。然而,EGCG的直接吸收是有限的,因为它的低口服生物利用度,有很大一部分到达结肠,在那里它与肠道微生物群广泛相互作用。这种微生物相互作用对于EGCG的生物转化和实现其健康促进潜力至关重要,但其潜在机制仍有待充分阐明。本文综述了EGCG的结构特征、代谢及其与肠道菌群的相互作用,并通过肠道相关轴综述了EGCG在肠道健康和全身效应中的作用,并对未来的研究进行了展望。首先阐述了EGCG的结构特点,EGCG是一种含有多个羟基的多酚结构的黄烷-3-醇,其抗氧化和生物活性与苯环和没食子酸酯部分的特定排列有关。其次,概述了其代谢过程,在小肠的有限吸收,小肠和肝脏的酶促代谢(包括甲基化,葡萄糖醛酸化和硫酸化),以及肠道微生物群在结肠中广泛的生物转化为代谢物,如表没食子儿茶素和没食子酸。第三,探索其对肠道的作用,通过促进有益菌群和抑制致病菌群来调节肠道菌群组成,通过上调紧密连接蛋白来增强肠道屏障功能,促进短链脂肪酸的产生。最后,本文阐述了EGCG如何通过肠-肝、肠-脑、肠-肾和肠-肺等相互关联的肠道轴调节关键的肠道相关健康通路及其对全身健康的更广泛影响,并概述了旨在进一步阐明EGCG促进健康潜力的前瞻性研究方向。
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引用次数: 0
Bioactives in Food-As-Medicine for Special Medical Purposes 特殊医药食品中的生物活性物质。
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-10-14 DOI: 10.1016/j.advnut.2025.100546
Xueyao Xi , Senyang Hu , Xunuo Zhang, Peng An, Yongting Luo, Junjie Luo, Yinhua Zhu
With rising global attention to health and the accelerating trend of population aging, the demand for Foods for Special Medical Purposes (FSMPs) has increased substantially. These products are formulated not only to meet the basic nutritional needs of individuals with specific diseases or physiological conditions but also to provide regulatory physiological effects. In this context, the “Food-As-Medicine” (FAM) concept has gained growing interest. FAM seeks to prevent and treat diseases through the incorporation of functional foods into health management strategies and aligns closely with the traditional Chinese medicine (TCM) theory of “Food-Medicine Homologous” (FMH). Guided by FMH principles, natural bioactive compounds such as polysaccharides, flavonoids, and saponins have drawn significant attention for their anti-inflammatory, antioxidant, and immunomodulatory properties. However, their broader application faces several challenges, including low extraction efficiency, complex purification procedures, and difficulties in ensuring stability, all of which hinder industrial-scale development. This review systematically explores the potential, challenges, and opportunities of FMH-based products in FSMPs, with a particular emphasis on infant nutrition, maternal health, and the management of chronic diseases in the elderly. Our findings highlight the dual value of FMH ingredients in both nutritional support and functional modulation. Furthermore, by integrating FMH theory with modern nutritional science, this review offers a scientific basis for the innovative development of FSMPs. Given the growing global market demand and the increasing dissemination of TCM culture, this field is poised to enter a new phase of development.
随着全球对健康的关注和人口老龄化趋势的加速,对特殊医疗用途食品的需求大幅增加。这些产品的配方不仅满足患有特定疾病或生理状况的个人的基本营养需求,而且还提供调节生理作用。在这种背景下,“食物即药物”(FAM)概念获得了越来越多的兴趣。FAM寻求通过将功能食品纳入健康管理策略来预防和治疗疾病,并与“食药同源”(FMH)的传统中医理论密切相关。在FMH原理的指导下,多糖、黄酮类化合物和皂苷等天然生物活性化合物因其抗炎、抗氧化和免疫调节特性而受到广泛关注。然而,它们的广泛应用面临着一些挑战,包括萃取效率低、纯化程序复杂、稳定性难以保证,这些都阻碍了工业规模的发展。这篇综述系统地探讨了fmh产品在FSMPs中的潜力、挑战和机遇,特别强调了婴儿营养、孕产妇健康和老年人慢性病的管理。我们的研究结果强调了FMH成分在营养支持和功能调节方面的双重价值。同时,将FMH理论与现代营养科学相结合,为fsmp的创新开发提供科学依据。随着全球市场需求的不断增长和中医药文化的不断传播,这一领域即将进入一个新的发展阶段。
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引用次数: 0
Upstream Interventions in Clinical Settings Focused on Nutrition to Prevent Obesity During the First 1000 Days: A Scoping Review 临床环境中的上游干预措施侧重于前1000天的营养预防肥胖:范围综述1。
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-10-09 DOI: 10.1016/j.advnut.2025.100529
Courtney T Luecking , Chelsea L Kracht , Mackenzie J Ferrante , Kameron J Moding , Elizabeth Kielb , Laura J Rolke , Brooke E Wagner , Jordan Colella , Katherine E Speirs , Cayla Robinson , Cody D Neshteruk
Nutritional exposures during pregnancy and the first 2 y of a child’s life influence growth and risk for obesity. Upstream interventions that involve policy, systems, and/or environmental approaches may support equitable nutrition and healthy growth early in life. Yet little is known about the application of these interventions in clinical settings. This scoping review characterized the breadth, generalizability, and methodological rigor of nutrition-focused, upstream interventions for obesity prevention during the first 1000 d in clinical settings. Eight databases were searched in November 2022 for policy, systems, and/or environmental approaches conducted during the first 1000 d. Titles, abstracts, and full texts were independently screened in duplicate, with conflicts resolved by a third reviewer. Extracted elements included study characteristics, reach, effectiveness, adoption, implementation, maintenance, and the Downs and Black study quality checklist. Of the 73,969 records identified, 185 reports representing 126 studies were included. Studies frequently involved combinations of system (98%), environmental (56%), and/or individual (87%) approaches in prenatal care (35%), hospital (22%), or primary care (21%) settings. Over half (62%) were conducted with socially disadvantaged families. More studies reported positive effects on feeding practices (71%), child diet (70%), breastfeeding (67%), and maternal diet (62%), compared with child (31%) or maternal (48%) weight and growth outcomes. Variation in outcome reporting and measurement limited the ability to make conclusions regarding effectiveness. Maintenance of upstream approaches was seldom reported. Study quality ranged from poor to good. Results suggest the promise of scaling adoption of policy, systems, and/or environmental approaches that enhance standard clinical care by incorporating nutrition-focused elements to support healthy feeding behaviors and growth. To achieve equitable nutrition and healthy growth early during the first 1000 d, implementation and evaluation of upstream policy efforts that integrate social and health care within and in collaboration with agencies beyond clinical settings may be warranted.
This trial was registered at Open Science Framework Registry as osf.io/bqck5 (https://doi.org/10.17605/OSF.IO/SXZMK).
怀孕期间和儿童生命最初两年的营养暴露会影响生长和肥胖的风险。涉及政策、系统和/或环境方法的上游干预措施可支持生命早期的公平营养和健康成长。然而,人们对这些干预措施在临床环境中的应用知之甚少。这一范围综述的特点是在临床环境的前1000天内,以营养为重点的预防肥胖的上游干预措施的广度、普遍性和方法的严谨性。2022年11月,对八个数据库进行了检索,以查找前1000天内实施的政策、系统和/或环境方法。题目、摘要和全文一式两份独立筛选,冲突由第三审稿人解决。提取的要素包括研究特征、覆盖范围、有效性、采用、实施、维护,以及Downs和Black研究质量检查表。在确定的73969份记录中,包括185份报告,代表126项研究。研究经常涉及产前护理(35%)、医院(22%)或初级保健(21%)设置中的系统(98%)、环境(56%)和/或个人(87%)方法的组合。超过一半(62%)是在社会弱势家庭进行的。与儿童体重和生长结果(31%)或母亲体重和生长结果(48%)相比,更多的研究报告对喂养方法(71%)、儿童饮食(70%)、母乳喂养(67%)和母亲饮食(62%)产生了积极影响。结果报告和测量的差异限制了对有效性得出结论的能力。上游方法的维护很少被报道。学习质量有好有坏。研究结果表明,通过纳入以营养为重点的元素来支持健康的喂养行为和生长,从而加强标准临床护理的政策、系统和/或环境方法的大规模采用有望实现。为了在头1 000天的早期实现公平营养和健康成长,可能有必要执行和评估上游政策努力,在临床环境之外的机构内部和与之合作,将社会保健和保健结合起来。综述注册:开放科学框架注册,osf。io / bqck5, https://doi.org/10.17605/OSF.IO/SXZMK。
{"title":"Upstream Interventions in Clinical Settings Focused on Nutrition to Prevent Obesity During the First 1000 Days: A Scoping Review","authors":"Courtney T Luecking ,&nbsp;Chelsea L Kracht ,&nbsp;Mackenzie J Ferrante ,&nbsp;Kameron J Moding ,&nbsp;Elizabeth Kielb ,&nbsp;Laura J Rolke ,&nbsp;Brooke E Wagner ,&nbsp;Jordan Colella ,&nbsp;Katherine E Speirs ,&nbsp;Cayla Robinson ,&nbsp;Cody D Neshteruk","doi":"10.1016/j.advnut.2025.100529","DOIUrl":"10.1016/j.advnut.2025.100529","url":null,"abstract":"<div><div>Nutritional exposures during pregnancy and the first 2 y of a child’s life influence growth and risk for obesity. Upstream interventions that involve policy, systems, and/or environmental approaches may support equitable nutrition and healthy growth early in life. Yet little is known about the application of these interventions in clinical settings. This scoping review characterized the breadth, generalizability, and methodological rigor of nutrition-focused, upstream interventions for obesity prevention during the first 1000 d in clinical settings. Eight databases were searched in November 2022 for policy, systems, and/or environmental approaches conducted during the first 1000 d. Titles, abstracts, and full texts were independently screened in duplicate, with conflicts resolved by a third reviewer. Extracted elements included study characteristics, reach, effectiveness, adoption, implementation, maintenance, and the Downs and Black study quality checklist. Of the 73,969 records identified, 185 reports representing 126 studies were included. Studies frequently involved combinations of system (98%), environmental (56%), and/or individual (87%) approaches in prenatal care (35%), hospital (22%), or primary care (21%) settings. Over half (62%) were conducted with socially disadvantaged families. More studies reported positive effects on feeding practices (71%), child diet (70%), breastfeeding (67%), and maternal diet (62%), compared with child (31%) or maternal (48%) weight and growth outcomes. Variation in outcome reporting and measurement limited the ability to make conclusions regarding effectiveness. Maintenance of upstream approaches was seldom reported. Study quality ranged from poor to good. Results suggest the promise of scaling adoption of policy, systems, and/or environmental approaches that enhance standard clinical care by incorporating nutrition-focused elements to support healthy feeding behaviors and growth. To achieve equitable nutrition and healthy growth early during the first 1000 d, implementation and evaluation of upstream policy efforts that integrate social and health care within and in collaboration with agencies beyond clinical settings may be warranted.</div><div>This trial was registered at Open Science Framework Registry as osf.io/bqck5 (<span><span>https://doi.org/10.17605/OSF.IO/SXZMK</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 12","pages":"Article 100529"},"PeriodicalIF":9.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to ‘Optimal Intake of Animal-Source Foods: A Scoping Review to Inform a New WHO Guideline’ [Advances in Nutrition 16 (2025) 100467] “动物源食品的最佳摄入量:为世卫组织新指南提供信息的范围审查”[营养进展16(2025)100467]的勘误表。
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-10-01 DOI: 10.1016/j.advnut.2025.100507
Magali Rios-Leyvraz , Jason Montez
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引用次数: 0
Reference Values for Minerals in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study 母乳中矿物质的参考值:母亲、婴儿和哺乳质量(MILQ)研究。
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-10-01 DOI: 10.1016/j.advnut.2025.100431
Lindsay H Allen , M Munirul Islam , Gilberto Kac , Kim F Michaelsen , Sophie E Moore , Maria Andersson , Janet M Peerson , Andrew M Doel , Daphna K Dror , Setareh Shahab-Ferdows , Daniela de Barros Mucci , Gabriela Torres Silva , Daniela Hampel
This fifth article in the series presenting reference values for nutrients in human milk describes minerals. The Mothers, Infants and Lactation Quality (MILQ) and Early-MILQ studies collected human milk samples throughout the first 8.5 mo of lactation in 1242 well-nourished women in Bangladesh, Brazil, Denmark, and The Gambia. All minerals were measured by inductively coupled plasma-mass spectrometry. Although pooled MILQ medians from 1 to 6 mo are within ∼10% of the concentration used by the Institute of Medicine (IOM) for magnesium, potassium, calcium, and copper, they are ∼50% of the IOM value for zinc and selenium, and ∼75% of the IOM value for sodium and iron. For zinc, sodium, and iron, the discrepancy can be explained by the IOM’s use of values from early lactation (<3 mo) when the milk nutrient concentrations are higher; in contrast, for potassium the IOM benchmark concentration is consistent with later lactation (6 mo) in MILQ. Pooled median MILQ phosphorus from 1 to 6 mo is 120% of the concentration selected by the IOM. Milk iodine concentrations in MILQ varied among sites, reflecting the differing national policies for salt iodization. Total daily median mineral intakes from 1 to 6 mo were 49%–55% of IOM adequate intakes (AIs) for zinc and selenium, 74%–90% of AIs for sodium, iron, and magnesium, and 110%–125% of AIs for copper, potassium, calcium, and phosphorus. For zinc, sodium, iron, and potassium, differences can be explained by the reference time frame during lactation. The MILQ study mineral concentrations are provided as percentile curves to enable comparison and interpretation. Importantly, the MILQ data show marked changes in milk mineral concentrations during the first 6 mo of lactation, an observation often missed because of the absence of data representing a spectrum of time postpartum in previously published data.
本系列的第五篇文章介绍了母乳中营养素的参考值,描述了矿物质。母亲、婴儿和哺乳质量(MILQ)和早期MILQ研究收集了孟加拉国、巴西、丹麦和冈比亚1242名营养良好的妇女在哺乳期前8.5个月的母乳样本。所有矿物均采用电感耦合等离子体质谱法测定。虽然从1到6个月的合并MILQ中位数在医学研究所(IOM)使用的镁、钾、钙和铜浓度的10%以内,但它们是锌和硒的IOM值的50%,钠和铁的IOM值的75%。对于锌、钠和铁,这种差异可以用IOM使用哺乳期早期的数值来解释(
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引用次数: 0
Invitation for Nominations for 2026 2026年的提名邀请
IF 9.2 1区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2025-10-01 DOI: 10.1016/j.advnut.2025.100544
{"title":"Invitation for Nominations for 2026","authors":"","doi":"10.1016/j.advnut.2025.100544","DOIUrl":"10.1016/j.advnut.2025.100544","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 10","pages":"Article 100544"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Advances in Nutrition
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