Advances in Nutrition最新文献

{"title":"Bioactives in Food-As-Medicine for Special Medical Purposes","authors":"Xueyao Xi ,&nbsp;Senyang Hu ,&nbsp;Xunuo Zhang,&nbsp;Peng An,&nbsp;Yongting Luo,&nbsp;Junjie Luo,&nbsp;Yinhua Zhu","doi":"10.1016/j.advnut.2025.100546","DOIUrl":"10.1016/j.advnut.2025.100546","url":null,"abstract":"<div><div>With rising global attention to health and the accelerating trend of population aging, the demand for Foods for Special Medical Purposes (FSMPs) has increased substantially. These products are formulated not only to meet the basic nutritional needs of individuals with specific diseases or physiological conditions but also to provide regulatory physiological effects. In this context, the “Food-As-Medicine” (FAM) concept has gained growing interest. FAM seeks to prevent and treat diseases through the incorporation of functional foods into health management strategies and aligns closely with the traditional Chinese medicine (TCM) theory of “Food-Medicine Homologous” (FMH). Guided by FMH principles, natural bioactive compounds such as polysaccharides, flavonoids, and saponins have drawn significant attention for their anti-inflammatory, antioxidant, and immunomodulatory properties. However, their broader application faces several challenges, including low extraction efficiency, complex purification procedures, and difficulties in ensuring stability, all of which hinder industrial-scale development. This review systematically explores the potential, challenges, and opportunities of FMH-based products in FSMPs, with a particular emphasis on infant nutrition, maternal health, and the management of chronic diseases in the elderly. Our findings highlight the dual value of FMH ingredients in both nutritional support and functional modulation. Furthermore, by integrating FMH theory with modern nutritional science, this review offers a scientific basis for the innovative development of FSMPs. Given the growing global market demand and the increasing dissemination of TCM culture, this field is poised to enter a new phase of development.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 12","pages":"Article 100546"},"PeriodicalIF":9.2,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upstream Interventions in Clinical Settings Focused on Nutrition to Prevent Obesity During the First 1000 Days: A Scoping Review","authors":"Courtney T Luecking ,&nbsp;Chelsea L Kracht ,&nbsp;Mackenzie J Ferrante ,&nbsp;Kameron J Moding ,&nbsp;Elizabeth Kielb ,&nbsp;Laura J Rolke ,&nbsp;Brooke E Wagner ,&nbsp;Jordan Colella ,&nbsp;Katherine E Speirs ,&nbsp;Cayla Robinson ,&nbsp;Cody D Neshteruk","doi":"10.1016/j.advnut.2025.100529","DOIUrl":"10.1016/j.advnut.2025.100529","url":null,"abstract":"<div><div>Nutritional exposures during pregnancy and the first 2 y of a child’s life influence growth and risk for obesity. Upstream interventions that involve policy, systems, and/or environmental approaches may support equitable nutrition and healthy growth early in life. Yet little is known about the application of these interventions in clinical settings. This scoping review characterized the breadth, generalizability, and methodological rigor of nutrition-focused, upstream interventions for obesity prevention during the first 1000 d in clinical settings. Eight databases were searched in November 2022 for policy, systems, and/or environmental approaches conducted during the first 1000 d. Titles, abstracts, and full texts were independently screened in duplicate, with conflicts resolved by a third reviewer. Extracted elements included study characteristics, reach, effectiveness, adoption, implementation, maintenance, and the Downs and Black study quality checklist. Of the 73,969 records identified, 185 reports representing 126 studies were included. Studies frequently involved combinations of system (98%), environmental (56%), and/or individual (87%) approaches in prenatal care (35%), hospital (22%), or primary care (21%) settings. Over half (62%) were conducted with socially disadvantaged families. More studies reported positive effects on feeding practices (71%), child diet (70%), breastfeeding (67%), and maternal diet (62%), compared with child (31%) or maternal (48%) weight and growth outcomes. Variation in outcome reporting and measurement limited the ability to make conclusions regarding effectiveness. Maintenance of upstream approaches was seldom reported. Study quality ranged from poor to good. Results suggest the promise of scaling adoption of policy, systems, and/or environmental approaches that enhance standard clinical care by incorporating nutrition-focused elements to support healthy feeding behaviors and growth. To achieve equitable nutrition and healthy growth early during the first 1000 d, implementation and evaluation of upstream policy efforts that integrate social and health care within and in collaboration with agencies beyond clinical settings may be warranted.</div><div>This trial was registered at Open Science Framework Registry as osf.io/bqck5 (<span><span>https://doi.org/10.17605/OSF.IO/SXZMK</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 12","pages":"Article 100529"},"PeriodicalIF":9.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Optimal Intake of Animal-Source Foods: A Scoping Review to Inform a New WHO Guideline’ [Advances in Nutrition 16 (2025) 100467]","authors":"Magali Rios-Leyvraz ,&nbsp;Jason Montez","doi":"10.1016/j.advnut.2025.100507","DOIUrl":"10.1016/j.advnut.2025.100507","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 10","pages":"Article 100507"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Values for Minerals in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study","authors":"Lindsay H Allen ,&nbsp;M Munirul Islam ,&nbsp;Gilberto Kac ,&nbsp;Kim F Michaelsen ,&nbsp;Sophie E Moore ,&nbsp;Maria Andersson ,&nbsp;Janet M Peerson ,&nbsp;Andrew M Doel ,&nbsp;Daphna K Dror ,&nbsp;Setareh Shahab-Ferdows ,&nbsp;Daniela de Barros Mucci ,&nbsp;Gabriela Torres Silva ,&nbsp;Daniela Hampel","doi":"10.1016/j.advnut.2025.100431","DOIUrl":"10.1016/j.advnut.2025.100431","url":null,"abstract":"<div><div>This fifth article in the series presenting reference values for nutrients in human milk describes minerals. The Mothers, Infants and Lactation Quality (MILQ) and Early-MILQ studies collected human milk samples throughout the first 8.5 mo of lactation in 1242 well-nourished women in Bangladesh, Brazil, Denmark, and The Gambia. All minerals were measured by inductively coupled plasma-mass spectrometry. Although pooled MILQ medians from 1 to 6 mo are within ∼10% of the concentration used by the Institute of Medicine (IOM) for magnesium, potassium, calcium, and copper, they are ∼50% of the IOM value for zinc and selenium, and ∼75% of the IOM value for sodium and iron. For zinc, sodium, and iron, the discrepancy can be explained by the IOM’s use of values from early lactation (&lt;3 mo) when the milk nutrient concentrations are higher; in contrast, for potassium the IOM benchmark concentration is consistent with later lactation (6 mo) in MILQ. Pooled median MILQ phosphorus from 1 to 6 mo is 120% of the concentration selected by the IOM. Milk iodine concentrations in MILQ varied among sites, reflecting the differing national policies for salt iodization. Total daily median mineral intakes from 1 to 6 mo were 49%–55% of IOM adequate intakes (AIs) for zinc and selenium, 74%–90% of AIs for sodium, iron, and magnesium, and 110%–125% of AIs for copper, potassium, calcium, and phosphorus. For zinc, sodium, iron, and potassium, differences can be explained by the reference time frame during lactation. The MILQ study mineral concentrations are provided as percentile curves to enable comparison and interpretation. Importantly, the MILQ data show marked changes in milk mineral concentrations during the first 6 mo of lactation, an observation often missed because of the absence of data representing a spectrum of time postpartum in previously published data.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 ","pages":"Article 100431"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invitation for Nominations for 2026","authors":"","doi":"10.1016/j.advnut.2025.100544","DOIUrl":"10.1016/j.advnut.2025.100544","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 10","pages":"Article 100544"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future Applications of Human Milk Reference Values for Nutrients: A Global Resource for Maternal and Child Nutrition Research","authors":"Sophie E Moore ,&nbsp;Lindsay H Allen ,&nbsp;Gilberto Kac","doi":"10.1016/j.advnut.2025.100429","DOIUrl":"10.1016/j.advnut.2025.100429","url":null,"abstract":"<div><div>The World Health Organization recommends exclusive breastfeeding for the first 6 mo of life as human milk is considered to be the optimal form of nutrition to support infant health and development. Human milk provides many nutrient and non-nutrient bioactive compounds to young infants, including micronutrients. In contexts where diets are nutritionally poor, the concentration of micronutrients in human milk is lower, impacting infant's supply. However, understanding when lower values indicate the need for interventions and then evaluating the impact of interventions on maternal nutritional status and milk nutrient concentrations has been challenged by the absence of reliable reference values (RVs) for nutrient concentrations in human milk. The multicenter Mothers, Infants, and Lactation Quality (MILQ) and Early-MILQ studies were developed to establish evidence-based RVs for human milk nutrients. This paper presents and discusses the potential utility of these RVs as an international reference for global maternal and child health research.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 ","pages":"Article 100429"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Values for Fat-Soluble Vitamins in Human Milk: The Mothers, Infants and Lactation Quality (MILQ) Study","authors":"Gilberto Kac ,&nbsp;Kerry S Jones ,&nbsp;Sarah R Meadows ,&nbsp;Daniela Hampel ,&nbsp;M Munirul Islam ,&nbsp;Christian Mølgaard ,&nbsp;Sophie E Moore ,&nbsp;Daphna K Dror ,&nbsp;Setareh Shahab-Ferdows ,&nbsp;Daniela de Barros Mucci ,&nbsp;Amanda C Figueiredo ,&nbsp;Janet M Peerson ,&nbsp;Lindsay H Allen","doi":"10.1016/j.advnut.2025.100484","DOIUrl":"10.1016/j.advnut.2025.100484","url":null,"abstract":"<div><div>This fourth article in the series presenting reference values for nutrients in human milk describes the values for the fat-soluble vitamins A, E, and D. The Mothers, Infants and Lactation Quality (MILQ) and Early-MILQ studies collected human milk samples at multiple times during the first 8.5 mo of lactation, from 1242 well-nourished women in Bangladesh, Brazil, Denmark, and The Gambia. Vitamins A and E were measured using high-performance liquid chromatography, whereas vitamin D was measured by liquid chromatography-tandem mass spectrometry. Milk fat-soluble vitamin concentrations from the MILQ study were compared with those used by the Institute of Medicine (IOM) for setting recommendations for nutrient requirements of infants and with other selected data sets. MILQ median concentration was on par with the value used by the IOM for retinol activity equivalents except in early lactation, when they were higher. For α-tocopherol, MILQ median concentration was 76% of the IOM value. The estimate of 0.89 mg/L γ-tocopherol is novel, given that the IOM does not define a concentration in human milk. Although it is known that human milk does not meet infant requirements for vitamin D, results of the MILQ study suggest that actual median concentrations are 60%–80% of those estimated by the IOM. Total daily median intakes from 1 to 6 mo were 97%, 75%, and 6% of IOM adequate intakes for vitamin A, α-tocopherol, and vitamin D, respectively. The MILQ fat-soluble vitamin estimated percentile curves are provided to enable comparison and interpretation of data from other studies.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 ","pages":"Article 100484"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Significant Step Forward in Understanding Human Milk: the Mothers, Infants, and Lactation Quality Study","authors":"Andrew A Bremer","doi":"10.1016/j.advnut.2025.100509","DOIUrl":"10.1016/j.advnut.2025.100509","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 ","pages":"Article 100509"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Methodology: the Fixed-Quality Variable-Type Dietary Intervention","authors":"Andrew A Bremer","doi":"10.1016/j.advnut.2025.100508","DOIUrl":"10.1016/j.advnut.2025.100508","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 10","pages":"Article 100508"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Silent Weight of Nutrition Data in Glucagon-Like Peptide-1 Receptor Agonists Clinical Trials","authors":"Hassan S Dashti ,&nbsp;Lukasz Szczerbinski","doi":"10.1016/j.advnut.2025.100498","DOIUrl":"10.1016/j.advnut.2025.100498","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 10","pages":"Article 100498"},"PeriodicalIF":9.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}