首页 > 最新文献

JCIS open最新文献

英文 中文
Critical parameters controlling wettability in hydrogen underground storage - An analytical study 控制地下储氢库润湿性的关键参数分析研究
Q3 Materials Science Pub Date : 2022-12-01 DOI: 10.1016/j.jciso.2022.100063
Farzaneh Nazari , Rouhi Farajzadeh , Vahid J. Niasar

Hypothesis

The large-scale implementation of hydrogen economy requires immense storage spaces to facilitate the periodic storage/production cycles. Extensive modelling of hydrogen transport in porous media is required to comprehend the hydrogen-induced complexities prior to storage to avoid energy loss. Wettability of hydrogen-brine-rock systems influence flow properties (e.g. capillary pressure and relative permeability curves) and the residual saturations, which are all essential for subsurface hydrogen systems.

Model

This study aims to understand which parameters critically control the contact angle for hydrogen-brine-rock systems using the surface force analysis following the DLVO theory and sensitivity analysis. Furthermore, the effect of roughness is studied using the Cassie-Baxter model.

Findings

Our results reveal no considerable difference between H2 and other gases such as N2. Besides, the inclusion of roughness highly affects the observed apparent contact angles, and even lead to water-repelling features. It was observed that contact angle does not vary significantly with variations of surface charge and density at high salinity, which is representative for reservoir conditions. Based on the analysis, it is speculated that the influence of roughness on contact angle becomes significant at low water saturation (i.e. high capillary pressure).

假设氢经济的大规模实施需要巨大的储存空间,以促进周期性的储存/生产周期。为了在储存之前理解氢引起的复杂性,以避免能量损失,需要对多孔介质中的氢传输进行广泛的建模。氢-盐水-岩石体系的润湿性影响着流体性质(如毛细压力和相对渗透率曲线)和残余饱和度,这些都是地下氢体系所必需的。本研究旨在利用DLVO理论和敏感性分析的表面力分析,了解哪些参数对氢-盐水-岩石体系的接触角起关键控制作用。此外,利用Cassie-Baxter模型研究了粗糙度的影响。结果表明H2和其他气体(如N2)之间没有明显的差异。此外,粗糙度对观察到的视接触角有很大影响,甚至会产生拒水特性。观察到,在高矿化度条件下,接触角随表面电荷和密度的变化不明显,这对储层条件具有代表性。根据分析推测,粗糙度对接触角的影响在低含水饱和度(即毛管压力高)时更为显著。
{"title":"Critical parameters controlling wettability in hydrogen underground storage - An analytical study","authors":"Farzaneh Nazari ,&nbsp;Rouhi Farajzadeh ,&nbsp;Vahid J. Niasar","doi":"10.1016/j.jciso.2022.100063","DOIUrl":"10.1016/j.jciso.2022.100063","url":null,"abstract":"<div><h3>Hypothesis</h3><p>The large-scale implementation of hydrogen economy requires immense storage spaces to facilitate the periodic storage/production cycles. Extensive modelling of hydrogen transport in porous media is required to comprehend the hydrogen-induced complexities prior to storage to avoid energy loss. Wettability of hydrogen-brine-rock systems influence flow properties (e.g. capillary pressure and relative permeability curves) and the residual saturations, which are all essential for subsurface hydrogen systems.</p></div><div><h3>Model</h3><p>This study aims to understand which parameters critically control the contact angle for hydrogen-brine-rock systems using the surface force analysis following the DLVO theory and sensitivity analysis. Furthermore, the effect of roughness is studied using the Cassie-Baxter model.</p></div><div><h3>Findings</h3><p>Our results reveal no considerable difference between H<sub>2</sub> and other gases such as N<sub>2</sub>. Besides, the inclusion of roughness highly affects the observed apparent contact angles, and even lead to water-repelling features. It was observed that contact angle does not vary significantly with variations of surface charge and density at high salinity, which is representative for reservoir conditions. Based on the analysis, it is speculated that the influence of roughness on contact angle becomes significant at low water saturation (i.e. high capillary pressure).</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000216/pdfft?md5=92c5b695290b9f4cec2bff6de00a5075&pid=1-s2.0-S2666934X22000216-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41959748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A detailed and systematic study on rheological and physicochemical properties of rhamnolipid biosurfactant solutions 详细系统地研究了鼠李糖脂生物表面活性剂溶液的流变学和理化性质
Q3 Materials Science Pub Date : 2022-12-01 DOI: 10.1016/j.jciso.2022.100067
Mohd Bilal Khan, C. Sasmal

Biosurfactants are widely used in many industrial settings ranging from cosmetic to petroleum industries. Among various biosurfactants available in the market, rhamnolipid is a well-known bacterial biosurfactant produced by the Pseudomonas aeruginosa bacteria. However, despite its wide applications, no detailed and systematic study is available on the rheological characterization of this biosurfactant solution, which is an essential property to investigate for many practical applications. Therefore, this study aims to present a thorough and complete investigation of this biosurfactant's shear and extensional rheological behaviours. While steady shear and small amplitude oscillatory shear (SAOS) measurements were conducted to investigate the shear rheological behaviour, the dripping-onto-substrate (DoS) extensional rheometry technique was used to understand its extensional rheological behaviour. A chemically derived surfactant (cetyltrimethyl ammonium bromide (CTAB)) was also used in our analysis to show and discuss the qualitative and quantitative differences in their rheological behaviours. Along with the detailed rheological study, some studies on the physicochemical properties, such as surface tension, contact angle, particle size analysis, thermal stability, etc., were also conducted to make an overall comparison between the two surfactants. Both surfactants show strong shear-thinning and extensional hardening behaviors in shear and extensional rheological flows, respectively. However, the zero-shear rate viscosity and extensional viscosity are found to be larger for rhamnolipid surfactant solutions than for CTAB. The corresponding shear and extensional relaxation times also follow the same trend. Furthermore, the surface tension is found to be less, and the contact angle is found to be more for rhamnolipid biosurfactant than that for CTAB. Rhamnolipid shows more excellent thermal stability, particularly at high temperatures than CTAB. Therefore, the results and discussion presented in this study will help to choose the present rhamnolipid biosurfactant for any particular application, particularly where the knowledge of the rheological responses of a surfactant solution is essential.

生物表面活性剂广泛应用于许多工业环境,从化妆品到石油工业。在市面上的各种生物表面活性剂中,鼠李糖脂是一种众所周知的细菌生物表面活性剂,由铜绿假单胞菌生产。然而,尽管其应用广泛,但尚未对这种生物表面活性剂溶液的流变性能进行详细和系统的研究,而流变性能是研究许多实际应用的基本性质。因此,本研究旨在对这种生物表面活性剂的剪切和拉伸流变行为进行彻底和完整的研究。通过稳定剪切和小振幅振荡剪切(SAOS)测量来研究剪切流变行为,通过滴入-基底(DoS)拉伸流变学技术来了解其拉伸流变行为。化学衍生的表面活性剂十六烷基三甲基溴化铵(CTAB)也用于我们的分析,以显示和讨论其流变行为的定性和定量差异。在进行详细的流变性研究的同时,还对两种表面活性剂的表面张力、接触角、粒度分析、热稳定性等理化性质进行了研究,对两种表面活性剂进行了全面比较。两种表面活性剂分别在剪切和拉伸流变中表现出强烈的剪切减薄和拉伸硬化行为。然而,鼠李糖脂表面活性剂溶液的零剪切速率粘度和拉伸粘度比CTAB溶液大。相应的剪切松弛时间和拉伸松弛时间也遵循相同的趋势。与CTAB相比,鼠李糖脂生物表面活性剂的表面张力更小,接触角更大。鼠李糖脂表现出比CTAB更优异的热稳定性,特别是在高温下。因此,本研究的结果和讨论将有助于为任何特定应用选择目前的鼠李糖脂生物表面活性剂,特别是在表面活性剂溶液流变反应的知识是必不可少的地方。
{"title":"A detailed and systematic study on rheological and physicochemical properties of rhamnolipid biosurfactant solutions","authors":"Mohd Bilal Khan,&nbsp;C. Sasmal","doi":"10.1016/j.jciso.2022.100067","DOIUrl":"10.1016/j.jciso.2022.100067","url":null,"abstract":"<div><p>Biosurfactants are widely used in many industrial settings ranging from cosmetic to petroleum industries. Among various biosurfactants available in the market, rhamnolipid is a well-known bacterial biosurfactant produced by the <em>Pseudomonas aeruginosa</em> bacteria. However, despite its wide applications, no detailed and systematic study is available on the rheological characterization of this biosurfactant solution, which is an essential property to investigate for many practical applications. Therefore, this study aims to present a thorough and complete investigation of this biosurfactant's shear and extensional rheological behaviours. While steady shear and small amplitude oscillatory shear (SAOS) measurements were conducted to investigate the shear rheological behaviour, the dripping-onto-substrate (DoS) extensional rheometry technique was used to understand its extensional rheological behaviour. A chemically derived surfactant (cetyltrimethyl ammonium bromide (CTAB)) was also used in our analysis to show and discuss the qualitative and quantitative differences in their rheological behaviours. Along with the detailed rheological study, some studies on the physicochemical properties, such as surface tension, contact angle, particle size analysis, thermal stability, etc., were also conducted to make an overall comparison between the two surfactants. Both surfactants show strong shear-thinning and extensional hardening behaviors in shear and extensional rheological flows, respectively. However, the zero-shear rate viscosity and extensional viscosity are found to be larger for rhamnolipid surfactant solutions than for CTAB. The corresponding shear and extensional relaxation times also follow the same trend. Furthermore, the surface tension is found to be less, and the contact angle is found to be more for rhamnolipid biosurfactant than that for CTAB. Rhamnolipid shows more excellent thermal stability, particularly at high temperatures than CTAB. Therefore, the results and discussion presented in this study will help to choose the present rhamnolipid biosurfactant for any particular application, particularly where the knowledge of the rheological responses of a surfactant solution is essential.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000253/pdfft?md5=ea7f1eef80067bb49fafd728231bca11&pid=1-s2.0-S2666934X22000253-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41245556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Unsteady axisymmetric flow of nanofluid on nonlinearly expanding surface with variable fluid properties 纳米流体在变流体性质非线性膨胀表面上的非定常轴对称流动
Q3 Materials Science Pub Date : 2022-12-01 DOI: 10.1016/j.jciso.2022.100064
Sohita Rajput , Krishnendu Bhattacharyya , Amit Kumar Pandey , Ali J. Chamkha

The physical phenomena of nanofluid at high temperature motivate us to analyze problems with temperature-reliant fluid properties, like viscosity and thermal conductivity. Since in glass blowing, viscosity and thermal conductivity of the fluid may gets affected in such high temperature. This communication deals with the unsteady flow of nanofluid generated by nonlinear expansion of the surface. Temperature-dependent fluid viscosity and thermal conductivity are considered in the investigation of the problem. The flow of nanofluid is modeled using famous the Buongiorno's two-phase model, which includes the simultaneous effect of Brownian motion and thermophoresis diffusion. Appropriate transformations are adopted to obtain the ODEs from governing PDEs. Then MATLAB ‘bvp4c’ computation is used to solve the problem and to get a clear insight of the influences of various parameters. Graphical comparisons are made to check the accuracy of used numerical method. The study explores that heat transfer rate significantly enhances by the index of nonlinearity, variable viscosity and thermal conductivity parameters. Unsteadiness of the flow can be used as a controlling parameter to reduce the surface drag, heat and nano-mass transfer rate. Variable viscosity parameter leads to enhance the velocity near the surface and reducing the concentration of the nanoparticles. The thermal and concentration boundary layer thickens with thermal conductivity parameters. Nanofluid temperature and concentration of nanoparticles decay with nonlinear expanding index.

纳米流体在高温下的物理现象促使我们分析与温度相关的流体性质问题,如粘度和导热性。因为在吹制玻璃的过程中,这种高温会影响液体的粘度和导热性。本文讨论了纳米流体由于表面非线性膨胀而产生的非定常流动。在问题的研究中考虑了与温度相关的流体粘度和导热系数。采用著名的Buongiorno的两相模型来模拟纳米流体的流动,该模型包括布朗运动和热泳扩散的同时影响。采用适当的转换从控制的pde获得ode。然后利用MATLAB的“bvp4c”计算对问题进行求解,清楚地了解各参数的影响。通过图形比较,验证了所采用数值方法的准确性。研究发现,以非线性、变粘度和导热系数为指标,传热率显著提高。流动的不稳定性可以作为控制参数来降低表面阻力、传热和纳米传质率。黏度参数的变化会导致纳米颗粒在表面附近流速的提高和浓度的降低。随着导热系数的增加,边界层变厚。纳米流体温度和浓度随非线性膨胀指数衰减。
{"title":"Unsteady axisymmetric flow of nanofluid on nonlinearly expanding surface with variable fluid properties","authors":"Sohita Rajput ,&nbsp;Krishnendu Bhattacharyya ,&nbsp;Amit Kumar Pandey ,&nbsp;Ali J. Chamkha","doi":"10.1016/j.jciso.2022.100064","DOIUrl":"10.1016/j.jciso.2022.100064","url":null,"abstract":"<div><p>The physical phenomena of nanofluid at high temperature motivate us to analyze problems with temperature-reliant fluid properties, like viscosity and thermal conductivity. Since in glass blowing, viscosity and thermal conductivity of the fluid may gets affected in such high temperature. This communication deals with the unsteady flow of nanofluid generated by nonlinear expansion of the surface. Temperature-dependent fluid viscosity and thermal conductivity are considered in the investigation of the problem. The flow of nanofluid is modeled using famous the <em>Buongiorno's two-phase</em> model, which includes the simultaneous effect of Brownian motion and thermophoresis diffusion. Appropriate transformations are adopted to obtain the ODEs from governing PDEs. Then MATLAB ‘bvp4c’ computation is used to solve the problem and to get a clear insight of the influences of various parameters. Graphical comparisons are made to check the accuracy of used numerical method. The study explores that heat transfer rate significantly enhances by the index of nonlinearity, variable viscosity and thermal conductivity parameters. Unsteadiness of the flow can be used as a controlling parameter to reduce the surface drag, heat and nano-mass transfer rate. Variable viscosity parameter leads to enhance the velocity near the surface and reducing the concentration of the nanoparticles. The thermal and concentration boundary layer thickens with thermal conductivity parameters. Nanofluid temperature and concentration of nanoparticles decay with nonlinear expanding index.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000228/pdfft?md5=b1fad3816767300453d94cff6ac96db9&pid=1-s2.0-S2666934X22000228-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41588285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Effect of nanoconfinement and pore geometry on point of zero charge in synthesized mesoporous siliceous materials 纳米约束和孔几何对合成介孔硅质材料零电荷点的影响
Q3 Materials Science Pub Date : 2022-12-01 DOI: 10.1016/j.jciso.2022.100069
Andrew T. Jacobson , Chen Chen , Janet C. Dewey , Grant C. Copeland , Wayne T. Allen , Bryony Richards , John P. Kaszuba , Adri C.T. van Duin , Hyeyoung Cho , Milind Deo , Yuqi She , Thomas P. Martin

Fluid-rock interactions may differ in mesopores (2–50 ​nm diameter) compared to macropores (>50 ​nm diameter). This study evaluates the influence of nano-confinement and pore geometry on point of zero charge (PZC) and hence surface charge and adsorption. PZC was determined for a suite of synthetic mesoporous amorphous silica materials and compared to the PZC of macroporous and non-porous amorphous silica. Reactive molecular dynamics simulations using ReaxFF determined surface equilibrium constants (pK) and clarified the large range of PZC values reported for macroporous and non-porous amorphous silica. Potentiometric titrations measured PZC and pK values of three mesoporous amorphous silica materials (SBA-15, SBA-16, and MCM-41) possessing a range of pore diameters (∼4–13 ​nm) and distinct pore geometries (cylindrical pores in a hexagonal lattice, spherical pores in a body-centered-cubic lattice, and hexagonal pores arranged in a hexagonal lattice); fluids were pre-saturated with silica to inhibit reaction with pore walls. Results are integrated with data from more than 150 published experimental studies. Neither nano-confinement nor pore geometry affects the PZC of the mesoporous amorphous silica materials. These results have implications for adsorption chemistry under confinement in mesoporous siliceous natural systems such as shales.

与大孔(直径50纳米)相比,中孔(直径2-50纳米)的流体-岩石相互作用可能有所不同。本研究评估了纳米约束和孔隙几何形状对零电荷点(PZC)以及表面电荷和吸附的影响。测定了一组合成的介孔非晶二氧化硅材料的PZC,并与大孔和非孔非晶二氧化硅的PZC进行了比较。使用ReaxFF进行反应分子动力学模拟,确定了大孔和非孔非晶二氧化硅的表面平衡常数(pK),并澄清了大范围的PZC值。电位滴定法测量了三种介孔无定形二氧化硅材料(SBA-15、SBA-16和MCM-41)的PZC和pK值,这些材料具有不同的孔径范围(~ 4-13 nm)和不同的孔隙几何形状(六边形晶格的圆柱形孔、体心立方晶格的球形孔和六边形晶格排列的六边形孔);流体被二氧化硅预饱和以抑制与孔壁的反应。结果与150多项已发表的实验研究的数据相结合。纳米约束和孔几何形状都不影响介孔非晶硅材料的PZC。这些结果对页岩等介孔硅质自然体系在约束条件下的吸附化学具有指导意义。
{"title":"Effect of nanoconfinement and pore geometry on point of zero charge in synthesized mesoporous siliceous materials","authors":"Andrew T. Jacobson ,&nbsp;Chen Chen ,&nbsp;Janet C. Dewey ,&nbsp;Grant C. Copeland ,&nbsp;Wayne T. Allen ,&nbsp;Bryony Richards ,&nbsp;John P. Kaszuba ,&nbsp;Adri C.T. van Duin ,&nbsp;Hyeyoung Cho ,&nbsp;Milind Deo ,&nbsp;Yuqi She ,&nbsp;Thomas P. Martin","doi":"10.1016/j.jciso.2022.100069","DOIUrl":"10.1016/j.jciso.2022.100069","url":null,"abstract":"<div><p>Fluid-rock interactions may differ in mesopores (2–50 ​nm diameter) compared to macropores (&gt;50 ​nm diameter). This study evaluates the influence of nano-confinement and pore geometry on point of zero charge (PZC) and hence surface charge and adsorption. PZC was determined for a suite of synthetic mesoporous amorphous silica materials and compared to the PZC of macroporous and non-porous amorphous silica. Reactive molecular dynamics simulations using ReaxFF determined surface equilibrium constants (<em>pK</em>) and clarified the large range of PZC values reported for macroporous and non-porous amorphous silica. Potentiometric titrations measured PZC and <em>pK</em> values of three mesoporous amorphous silica materials (SBA-15, SBA-16, and MCM-41) possessing a range of pore diameters (∼4–13 ​nm) and distinct pore geometries (cylindrical pores in a hexagonal lattice, spherical pores in a body-centered-cubic lattice, and hexagonal pores arranged in a hexagonal lattice); fluids were pre-saturated with silica to inhibit reaction with pore walls. Results are integrated with data from more than 150 published experimental studies. Neither nano-confinement nor pore geometry affects the PZC of the mesoporous amorphous silica materials. These results have implications for adsorption chemistry under confinement in mesoporous siliceous natural systems such as shales.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000277/pdfft?md5=a1e32114b29f53dee74bb69e03f5d8e1&pid=1-s2.0-S2666934X22000277-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42764295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Microgels-on-macrogel: A simple cytophilic surface makeover of soft agarose substrates 微凝胶对大凝胶:软琼脂糖底物的简单嗜细胞表面改造
Q3 Materials Science Pub Date : 2022-10-01 DOI: 10.1016/j.jciso.2022.100056
Xueying Yu , Fang Cheng , Wei He

Microgel-mediated surface modification has shown great promises for a variety of metallic and non-metallic substrates. Yet, despite its compelling merits, this approach is less implemented on soft hydrogel substrates. Here, using the well-known bioinert agarose hydrogel as an example, we highlight a microgels-on-macrogel strategy that readily confers cytophilicity to the agarose surface toward anchorage-dependent cells. Specifically, we selected glycerol diglycidyl ether to tailor design polyetheramine-bisepoxide-based cationic microgels with more prominent ether alcohol features for enhanced chemical compatibility with agarose. Through a simple drop casting method, concurrent modifications of chemical, morphological and mechanical properties of the surface of agarose gel were then achieved with these microgels bound to the surface in a non-covalent yet robust manner. With the mere introduction of the cationic microgels, not only was the non-adhesive agarose surface effectively transformed to be cytophilic shown by the favorable responses from the in vitro culture of MC3T3-E1 cells, but also was hydrophobic reservoir function integrated conveniently. The demonstration of its feasibility and versatility warrants continued research of this straightforward microgels-on-macrogel strategy, which could be of value particularly for the development of novel biointerfaces.

微凝胶介导的表面修饰在各种金属和非金属基底上显示出巨大的前景。然而,尽管它有令人信服的优点,这种方法很少在软水凝胶基质上实现。在这里,以众所周知的生物惰性琼脂糖水凝胶为例,我们强调了一种微凝胶对大凝胶的策略,这种策略很容易赋予琼脂糖表面对锚定依赖性细胞的细胞亲和性。具体来说,我们选择甘油二缩水甘油醚来定制设计具有更突出醚醇特征的聚醚胺-双环氧化合物基阳离子微凝胶,以增强与琼脂糖的化学相容性。通过一种简单的滴铸法,这些微凝胶以非共价但坚固的方式结合在琼脂糖凝胶表面,从而实现了琼脂糖凝胶表面化学、形态和机械性能的同时修饰。仅引入阳离子微凝胶,就能将无黏附的琼脂糖表面有效转化为亲细胞性,并在MC3T3-E1细胞体外培养中表现出良好的反应,同时还能方便地整合疏水储层功能。它的可行性和多功能性证明了这种直接的微凝胶对大凝胶策略的继续研究,这对于开发新的生物界面尤其有价值。
{"title":"Microgels-on-macrogel: A simple cytophilic surface makeover of soft agarose substrates","authors":"Xueying Yu ,&nbsp;Fang Cheng ,&nbsp;Wei He","doi":"10.1016/j.jciso.2022.100056","DOIUrl":"10.1016/j.jciso.2022.100056","url":null,"abstract":"<div><p>Microgel-mediated surface modification has shown great promises for a variety of metallic and non-metallic substrates. Yet, despite its compelling merits, this approach is less implemented on soft hydrogel substrates. Here, using the well-known bioinert agarose hydrogel as an example, we highlight a microgels-on-macrogel strategy that readily confers cytophilicity to the agarose surface toward anchorage-dependent cells. Specifically, we selected glycerol diglycidyl ether to tailor design polyetheramine-bisepoxide-based cationic microgels with more prominent ether alcohol features for enhanced chemical compatibility with agarose. Through a simple drop casting method, concurrent modifications of chemical, morphological and mechanical properties of the surface of agarose gel were then achieved with these microgels bound to the surface in a non-covalent yet robust manner. With the mere introduction of the cationic microgels, not only was the non-adhesive agarose surface effectively transformed to be cytophilic shown by the favorable responses from the in vitro culture of MC3T3-E1 cells, but also was hydrophobic reservoir function integrated conveniently. The demonstration of its feasibility and versatility warrants continued research of this straightforward microgels-on-macrogel strategy, which could be of value particularly for the development of novel biointerfaces.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000149/pdfft?md5=7770595cfb3f696708266799256f07b0&pid=1-s2.0-S2666934X22000149-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47998796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The influence of calcium ions (Ca2+) on the enzymatic hydrolysis of lipopolysaccharide aggregates to liberate free fatty acids (FFA) in aqueous solution 钙离子(Ca2+)对水溶液中脂多糖聚集体酶解释放游离脂肪酸(FFA)的影响
Q3 Materials Science Pub Date : 2022-10-01 DOI: 10.1016/j.jciso.2022.100058
Jessika Pazol , Thomas M. Weiss , Cristian D. Martínez , Orestes Quesada , Eduardo Nicolau

The chemical environment in aqueous solutions greatly influences the ability of amphiphilic molecules such as lipopolysaccharides (LPS) to aggregate into different structural phases in aqueous solutions. Understanding the substrate's morphology and conditions of aqueous solution that favor both enzymatic activity and the disruption of LPS aggregates are crucial in developing agents that can counteract the new trend of multidrug resistance by gram-negative bacteria. In this study, we developed two LPS morphologies using LPS from Escherichia coli as a model to study the in vitro hydrolytic response when using a lipase treatment. The hydrolysis was performed using lipase b from Candida antarctica to understand the catalytic effect in removing fatty acids from its lipid A moiety on different LPS aggregates. Physical and chemical characterizations of the products included dynamic light scattering, small angle X-ray scattering, Fourier transform infrared spectroscopy, thin-layer chromatography, and gas chromatography. Our results suggest a trend of prominent hydrolytic response (72% enhancement) upon the addition of calcium ions to induce LPS aggregates into bilayer formations. Moreover, our results revealed the detection of myristic acid (C14:0) as the product of the hydrolysis when using RaLPS in its aggregate forms.

水溶液中的化学环境极大地影响了脂多糖(LPS)等两亲分子在水溶液中聚集成不同结构相的能力。了解底物的形态和有利于酶活性和LPS聚集体破坏的水溶液条件对于开发能够对抗革兰氏阴性菌多药耐药新趋势的药物至关重要。在这项研究中,我们开发了两种LPS形态,以大肠杆菌的LPS为模型,研究脂肪酶处理时的体外水解反应。利用来自南极念珠菌的脂肪酶b进行水解,以了解其脂质A部分在不同LPS聚集体上去除脂肪酸的催化作用。对产物进行了动态光散射、小角x射线散射、傅里叶变换红外光谱、薄层色谱、气相色谱等理化表征。我们的研究结果表明,在添加钙离子诱导LPS聚集体形成双层结构时,有明显的水解反应趋势(增强72%)。此外,我们的研究结果显示,当以RaLPS的聚集体形式使用时,可以检测到肉豆蔻酸(C14:0)作为水解产物。
{"title":"The influence of calcium ions (Ca2+) on the enzymatic hydrolysis of lipopolysaccharide aggregates to liberate free fatty acids (FFA) in aqueous solution","authors":"Jessika Pazol ,&nbsp;Thomas M. Weiss ,&nbsp;Cristian D. Martínez ,&nbsp;Orestes Quesada ,&nbsp;Eduardo Nicolau","doi":"10.1016/j.jciso.2022.100058","DOIUrl":"10.1016/j.jciso.2022.100058","url":null,"abstract":"<div><p>The chemical environment in aqueous solutions greatly influences the ability of amphiphilic molecules such as lipopolysaccharides (LPS) to aggregate into different structural phases in aqueous solutions. Understanding the substrate's morphology and conditions of aqueous solution that favor both enzymatic activity and the disruption of LPS aggregates are crucial in developing agents that can counteract the new trend of multidrug resistance by gram-negative bacteria. In this study, we developed two LPS morphologies using LPS from <em>Escherichia coli</em> as a model to study the <em>in vitro</em> hydrolytic response when using a lipase treatment. The hydrolysis was performed using lipase b from <em>Candida antarctica</em> to understand the catalytic effect in removing fatty acids from its lipid A moiety on different LPS aggregates. Physical and chemical characterizations of the products included dynamic light scattering, small angle X-ray scattering, Fourier transform infrared spectroscopy, thin-layer chromatography, and gas chromatography. Our results suggest a trend of prominent hydrolytic response (72% enhancement) upon the addition of calcium ions to induce LPS aggregates into bilayer formations. Moreover, our results revealed the detection of myristic acid (C14:0) as the product of the hydrolysis when using RaLPS in its aggregate forms.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/2e/nihms-1877286.PMC10433262.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10421857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Ultrasonic atomization based fabrication of superhydrophobic and corrosion-resistant hydrolyzed MTMS/PVDF coatings 超声雾化法制备超疏水耐腐蚀水解MTMS/PVDF涂层
Q3 Materials Science Pub Date : 2022-10-01 DOI: 10.1016/j.jciso.2022.100059
Mohammad Shakourian , Saeed Rahemi Ardekani , Amir Bayat , Esmaiel Saievar-Iranizad , Wim Deferme

A stable self-cleaning superhydrophobic coating with reliable corrosion resistance was coated on the aluminum alloy 6061. A dense polyvinylidene fluoride (PVDF) layer was first coated by the doctor blade method, and hydrolyzed methyltrimethoxysilane (HMTMS) nanospheres were then deposited on top of the PVDF using ultrasonic spray hydrolysis technique. Superhydrophobic coatings with a contact angle (CA) of 167° and a sliding angle of 7 ​± ​1° were obtained. The superhydrophobic coating exhibited self-cleaning behavior. The corrosion resistance of the layers was investigated in a 3.5 ​wt% NaCl aqueous solution using potentiodynamic polarization measurement and electrochemical impedance spectroscopy techniques, indicating the high corrosion resistance of the flat PVDF barrier and the excellent resistance of the superhydrophobic coating. The charge transfer resistance of the bare aluminum substrate measured as 6.572 ​kΩ ​cm2 increased to 848.463 ​kΩ ​cm2 and 3.411 ​× ​103 ​kΩ ​cm2 with PVDF and HMTMS, respectively. The results showed that a proper superhydrophobic coating with good chemical stability could significantly increase the corrosion resistance of the substrate. We also showed the capability of the novel ultrasonic spray hydrolysis technique in fabricating stable superhydrophobic films for large-scale applications.

在6061铝合金表面涂覆了一种稳定的、具有可靠耐腐蚀性能的自清洁超疏水涂层。首先采用博士刀法包覆一层致密的聚偏氟乙烯(PVDF)层,然后采用超声喷雾水解技术在PVDF层上沉积水解的甲基三甲氧基硅烷(HMTMS)纳米球。获得了接触角(CA)为167°、滑动角为7±1°的超疏水涂层。超疏水涂层表现出自清洁行为。在3.5 wt% NaCl水溶液中,利用动电位极化测量和电化学阻抗谱技术研究了各层的耐蚀性,表明扁平PVDF屏障具有较高的耐蚀性,超疏水涂层具有优异的耐蚀性。在PVDF和HMTMS的作用下,裸铝基板的电荷转移电阻分别从6.572 kΩ cm2和3.411 × 103 kΩ cm2增加到848.463 kΩ cm2和3.411 × 103 kΩ cm2。结果表明,适当的超疏水涂层具有良好的化学稳定性,可以显著提高基体的耐蚀性。我们还展示了新型超声喷雾水解技术在大规模应用中制备稳定的超疏水膜的能力。
{"title":"Ultrasonic atomization based fabrication of superhydrophobic and corrosion-resistant hydrolyzed MTMS/PVDF coatings","authors":"Mohammad Shakourian ,&nbsp;Saeed Rahemi Ardekani ,&nbsp;Amir Bayat ,&nbsp;Esmaiel Saievar-Iranizad ,&nbsp;Wim Deferme","doi":"10.1016/j.jciso.2022.100059","DOIUrl":"10.1016/j.jciso.2022.100059","url":null,"abstract":"<div><p>A stable self-cleaning superhydrophobic coating with reliable corrosion resistance was coated on the aluminum alloy 6061. A dense polyvinylidene fluoride (PVDF) layer was first coated by the doctor blade method, and hydrolyzed methyltrimethoxysilane (HMTMS) nanospheres were then deposited on top of the PVDF using ultrasonic spray hydrolysis technique. Superhydrophobic coatings with a contact angle (CA) of 167° and a sliding angle of 7 ​± ​1° were obtained. The superhydrophobic coating exhibited self-cleaning behavior. The corrosion resistance of the layers was investigated in a 3.5 ​wt% NaCl aqueous solution using potentiodynamic polarization measurement and electrochemical impedance spectroscopy techniques, indicating the high corrosion resistance of the flat PVDF barrier and the excellent resistance of the superhydrophobic coating. The charge transfer resistance of the bare aluminum substrate measured as 6.572 ​kΩ ​cm<sup>2</sup> increased to 848.463 ​kΩ ​cm<sup>2</sup> and 3.411 ​× ​10<sup>3</sup> ​kΩ ​cm<sup>2</sup> with PVDF and HMTMS, respectively. The results showed that a proper superhydrophobic coating with good chemical stability could significantly increase the corrosion resistance of the substrate. We also showed the capability of the novel ultrasonic spray hydrolysis technique in fabricating stable superhydrophobic films for large-scale applications.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000174/pdfft?md5=1feab1c45b15bc269eaa3df5e8c619d8&pid=1-s2.0-S2666934X22000174-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44962780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Molecular area dependences of monolayers at the air/water interface 空气/水界面单分子膜的分子面积依赖性
Q3 Materials Science Pub Date : 2022-10-01 DOI: 10.1016/j.jciso.2022.100057
Elena S. Kartashynska , Dieter Vollhardt

The quantum chemical approach and a thermodynamic model for amphiphilic monolayers are used to find the temperature dependence of the area per amphiphile molecule in a monolayer at the onset of liquid-expanded – liquid-condensed phase transition (Ac). Quantum chemical calculations within the semiempiric PM3 method for clusterization thermodynamics and structure of surfactant dimers and trimers are used, as well as for assessment of their molecular area in an aggregate. Calculations are done for seven amphiphile classes: saturated and ethoxylated alcohols, saturated and unsaturated carboxylic acids, α-hydroxylic acids, N-acyl-substituted alanine and dialkyl-substituted melamine that are well experimentally explored. Calculations reflect the experimental data and show that a temperature increase leads to decrease of Ac for an amphiphile with a given alkyl chain length, and vice versa with a chain length increase at a fixed temperature the Ac value grows. It was shown that as the temperature increases the increment of Ac per methylene unit of the hydrocarbon chain becomes less significant. The average values of the slope reflecting the change of Ac per 1 ​°C for saturated and ethoxylated alcohols, saturated, cis- and trans-unsaturated carboxylic acids, α-hydroxylic acids, N-acyl-substituted alanine and dialkyl-substituted melamine are 0.57, 1.32, 1.14, 1.26, 1.15, 0.66, 1.07 and 0.67 ​Å2/°С, respectively. These data are quite similar to the experimental values of dAcdT for tetradecanoic acid, dipalmitoyl-phosphatidylcholine and dipalmitoyl phosphatididic acid. The proposed approach can be used as a predictive tool for amphiphiles lacking experimental data.

利用量子化学方法和两亲性单层的热力学模型,研究了液体膨胀-液体凝聚相变(Ac)发生时单层中两亲分子面积的温度依赖性。量子化学计算在半经验PM3方法中用于聚类热力学和表面活性剂二聚体和三聚体的结构,以及用于评估它们在聚集体中的分子面积。计算完成了七个两亲类:饱和和乙氧基化醇,饱和和不饱和羧酸,α-羟基酸,n -酰基取代丙氨酸和二烷基取代三聚氰胺,这是很好的实验探索。计算结果反映了实验数据,表明温度升高导致烷基链长度一定的两亲化合物的Ac值减小,反之,在一定温度下,随着链长度的增加,Ac值增大。结果表明,随着温度的升高,烃链上每亚甲基单位Ac的增量变得不那么显著。饱和和乙氧基化醇、饱和、顺式和反式不饱和羧酸、α-羟基酸、n -酰基取代丙氨酸和二烷基取代三聚氰胺每1°C反映Ac变化的斜率平均值分别为0.57、1.32、1.14、1.26、1.15、0.66、1.07和0.67 Å2/°С。这些数据与十四烷酸、双棕榈酰磷脂酰胆碱和双棕榈酰磷脂酰二酸的- dddt的实验值非常相似。该方法可作为缺乏实验数据的两亲动物的预测工具。
{"title":"Molecular area dependences of monolayers at the air/water interface","authors":"Elena S. Kartashynska ,&nbsp;Dieter Vollhardt","doi":"10.1016/j.jciso.2022.100057","DOIUrl":"10.1016/j.jciso.2022.100057","url":null,"abstract":"<div><p>The quantum chemical approach and a thermodynamic model for amphiphilic monolayers are used to find the temperature dependence of the area per amphiphile molecule in a monolayer at the onset of liquid-expanded – liquid-condensed phase transition (A<sub>c</sub>). Quantum chemical calculations within the semiempiric PM3 method for clusterization thermodynamics and structure of surfactant dimers and trimers are used, as well as for assessment of their molecular area in an aggregate. Calculations are done for seven amphiphile classes: saturated and ethoxylated alcohols, saturated and unsaturated carboxylic acids, α-hydroxylic acids, <em>N</em>-acyl-substituted alanine and dialkyl-substituted melamine that are well experimentally explored. Calculations reflect the experimental data and show that a temperature increase leads to decrease of A<sub>c</sub> for an amphiphile with a given alkyl chain length, and vice versa with a chain length increase at a fixed temperature the A<sub>c</sub> value grows. It was shown that as the temperature increases the increment of A<sub>c</sub> per methylene unit of the hydrocarbon chain becomes less significant. The average values of the slope reflecting the change of A<sub>c</sub> per 1 ​°C for saturated and ethoxylated alcohols, saturated, <em>cis</em>- and <em>trans</em>-unsaturated carboxylic acids, α-hydroxylic acids, <em>N</em>-acyl-substituted alanine and dialkyl-substituted melamine are 0.57, 1.32, 1.14, 1.26, 1.15, 0.66, 1.07 and 0.67 ​Å<sup>2</sup>/°С, respectively. These data are quite similar to the experimental values of <span><math><mrow><mo>−</mo><mfrac><mrow><mi>d</mi><msub><mi>A</mi><mi>c</mi></msub></mrow><mrow><mi>d</mi><mi>T</mi></mrow></mfrac></mrow></math></span> for tetradecanoic acid, dipalmitoyl-phosphatidylcholine and dipalmitoyl phosphatididic acid. The proposed approach can be used as a predictive tool for amphiphiles lacking experimental data.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000150/pdfft?md5=6298d3dbf0314be231dcd5b10bdae763&pid=1-s2.0-S2666934X22000150-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47304648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigations on the role of ionic liquid on the physicochemical characteristics and toxicological consequences of liposomes 离子液体对脂质体理化特性和毒理学影响的研究
Q3 Materials Science Pub Date : 2022-07-01 DOI: 10.1016/j.jciso.2022.100050
Manas Kumar Mandal , Emili Manna , Habiba Sultana , Manas Barai , Kartik Chandra Guchhait , Chandradipa Ghosh , Anuttam Patra , Kaushik Nag , Shin-ichi Yusa , Amiya Kumar Panda

Effect of 1-butyl-3-methylimidazolium chloride ionic liquid ([bmim]Cl, IL) on the monolayer/bilayer of either soy-phosphatidylcholine (SPC) or hydrogenated soy-phosphatidylcholine (HSPC), in combination with 30 ​mol% cholesterol (Chol), were investigated. Impact of IL on monolayers were explored by measuring the surface pressure (π)-area (A) isotherm with a Langmuir-surface balance. Lift-off area (A0) of the monomolecular films gradually increased [A0(HSPC+IL) ​> ​A0(SPC+IL)], collapse pressures (πc) decreased and passed through minima [πc(HSPC+IL) ​> ​πc(SPC+IL)] with increasing IL concentration ([IL]). Minimum molecular area (Amin) increased monotonously and compression moduli (Cs−1) followed the sequence (HSPC+IL) ​> ​(SPC+IL) at a particular π with respect to [IL]. Dynamic light scattering studies were carried out to determine the hydrodynamic diameter (dh), zeta potential (Z.P.) and polydispersity index (PDI) values while fluorescence anisotropy studies, using 7-hydroxycoumarin and 1,6-diphenyl-1,3,5-hexatriene, could reveal the micro-viscosity of liposomes. Increased size and rigidity, induced by IL, suggest the formation of leak-proof, condensed liposomes. Disruption of vesicles induced by IL were observed from transmission electron microscopic (TEM) studies. IL induced disintegration of liposome and kinetics of subsequent formation of adsorbed monolayer were accomplished by surface pressure-time isotherms. IL-induced liposomes were substantially less toxic as revealed by MTT assay. These liposomes are considered to be safely used as effective and controlled drug delivery systems.

研究了1-丁基-3-甲基咪唑氯离子液体([bmim]Cl, IL)对大豆磷脂酰胆碱(SPC)或氢化大豆磷脂酰胆碱(HSPC)在30 mol%胆固醇(Chol)作用下单层/双层反应的影响。利用Langmuir-surface balance测量表面压力(π)-面积(A)等温线,探讨IL对单层膜的影响。单分子膜的起飞面积(A0)逐渐增大[A0(HSPC+IL) >A0(SPC+IL)],坍塌压力(πc)减小并通过极小值[πc(HSPC+IL) >];πc(SPC+IL)]随IL浓度([IL])的增加而增加。最小分子面积(Amin)单调增加,压缩模量(Cs−1)依次为(HSPC+IL) >(SPC+IL)在一个特定的π相对于[IL]。采用动态光散射法测定脂质体的流体动力学直径(dh)、ζ电位(z.p)和多分散性指数(PDI),采用7-羟基香豆素和1,6-二苯基-1,3,5-己三烯荧光各向异性法测定脂质体的微粘度。IL诱导的增大的大小和刚性表明形成了防漏的凝聚脂质体。透射电镜观察到白介素对囊泡的破坏作用。通过表面压力-时间等温线来完成IL诱导脂质体的分解和随后形成吸附单层的动力学。MTT实验显示,il诱导的脂质体毒性明显降低。这些脂质体被认为是安全有效和受控的药物输送系统。
{"title":"Investigations on the role of ionic liquid on the physicochemical characteristics and toxicological consequences of liposomes","authors":"Manas Kumar Mandal ,&nbsp;Emili Manna ,&nbsp;Habiba Sultana ,&nbsp;Manas Barai ,&nbsp;Kartik Chandra Guchhait ,&nbsp;Chandradipa Ghosh ,&nbsp;Anuttam Patra ,&nbsp;Kaushik Nag ,&nbsp;Shin-ichi Yusa ,&nbsp;Amiya Kumar Panda","doi":"10.1016/j.jciso.2022.100050","DOIUrl":"10.1016/j.jciso.2022.100050","url":null,"abstract":"<div><p>Effect of 1-butyl-3-methylimidazolium chloride ionic liquid ([bmim]Cl, IL) on the monolayer/bilayer of either soy-phosphatidylcholine (SPC) or hydrogenated soy-phosphatidylcholine (HSPC), in combination with 30 ​mol% cholesterol (Chol), were investigated. Impact of IL on monolayers were explored by measuring the surface pressure (<em>π</em>)-area (<em>A</em>) isotherm with a Langmuir-surface balance. Lift-off area (<em>A</em><sub>0</sub>) of the monomolecular films gradually increased [<em>A</em><sub>0(HSPC+IL)</sub> ​&gt; ​<em>A</em><sub>0(SPC+IL)</sub>], collapse pressures (<em>π</em><sub>c</sub>) decreased and passed through minima [<em>π</em><sub>c(HSPC+IL)</sub> ​&gt; ​<em>π</em><sub>c(SPC+IL)</sub>] with increasing IL concentration ([IL]). Minimum molecular area (<em>A</em><sub>min</sub>) increased monotonously and compression moduli (<em>C</em><sub><em>s</em></sub><sup>−1</sup>) followed the sequence (HSPC+IL) ​&gt; ​(SPC+IL) at a particular <em>π</em> with respect to [IL]. Dynamic light scattering studies were carried out to determine the hydrodynamic diameter (<em>d</em><sub>h</sub>), zeta potential (<em>Z.P.</em>) and polydispersity index (<em>PDI</em>) values while fluorescence anisotropy studies, using 7-hydroxycoumarin and 1,6-diphenyl-1,3,5-hexatriene, could reveal the micro-viscosity of liposomes. Increased size and rigidity, induced by IL, suggest the formation of leak-proof, condensed liposomes. Disruption of vesicles induced by IL were observed from transmission electron microscopic (TEM) studies. IL induced disintegration of liposome and kinetics of subsequent formation of adsorbed monolayer were accomplished by surface pressure-time isotherms. IL-induced liposomes were substantially less toxic as revealed by MTT assay. These liposomes are considered to be safely used as effective and controlled drug delivery systems.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000083/pdfft?md5=b3c031b8bc57faa170728c813422837f&pid=1-s2.0-S2666934X22000083-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46542317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Micromechanical properties of spray-dried core-shell silica aggregates along with drug release tests 喷雾干燥核壳二氧化硅聚集体的微力学性能及药物释放试验
Q3 Materials Science Pub Date : 2022-07-01 DOI: 10.1016/j.jciso.2022.100052
Matthäus Barasinski , Carsten Schilde , Sebastian Melzig , Merle Hübner , Georg Garnweitner , Sabrina Zellmer

In order to enhance the quality of spray-dried products or to adjust material properties for new applications, precise control of the aggregate structure is desirable. For the purpose of preparing hierarchically structured aggregates in the micrometer range, the formulation of the suspension can be specifically designed, utilizing defined nanoparticulate building blocks to achieve a highly uniform structure and porosity. Further adjustments can be made by combining two types of primary particles that differ in size. Thereby, a segregation effect is observed, where nanoparticles with larger particle sizes accumulate rather within the core of an aggregate and those with smaller particle sizes gather mainly near the outer surface, resulting in the formation of a shell. Furthermore, it is possible to produce tailor-made porosities using template particles (e.g. polystyrene) of different sizes as part of the coarse and fine fractions. The removal of these particles by a subsequent tempering process can lead to aggregates with defined porous structures and thus, to different mechanical aggregate properties that can be specifically set by adjusting the process and formulation parameters. As a result, a promising building kit for the hierarchically structure formation via spray drying processes were achieved.

For the detailed characterization structural and mechanical material properties were investigated, using e.g. mercury intrusion and SEM. The influence of the formulation parameters of the suspension (primary particle size and template content) on the micromechanical properties of the aggregate structures was systematically investigated by nanoindentation to elucidate structure-property relationships regarding, for example elastic and plastic deformation. As a result, a correlation could be established between the experimentally determined mechanical parameters and the aggregate porosities.

Such microstructures with defined properties can be used in a variety of applications, including catalysis or as drug carriers. For instance, these spray-dried aggregates were loaded with ibuprofen as an exemplary active pharmaceutical ingredient and investigated with regard to their drug release behavior.

为了提高喷雾干燥产品的质量或调整材料性能以适应新的应用,需要精确控制骨料结构。为了在微米范围内制备层次结构的聚集体,可以专门设计悬浮液的配方,利用定义的纳米颗粒构建块来实现高度均匀的结构和孔隙度。进一步的调整可以通过结合两种不同大小的主要颗粒来进行。因此,可以观察到偏析效应,即较大粒径的纳米颗粒聚集在聚集体的核心内,而较小粒径的纳米颗粒主要聚集在外表面附近,从而形成一个壳。此外,可以使用不同尺寸的模板颗粒(例如聚苯乙烯)作为粗和细馏分的一部分来生产定制的孔隙率。通过随后的回火工艺去除这些颗粒可以使集料具有明确的多孔结构,从而可以通过调整工艺和配方参数来具体设置不同的机械集料性能。因此,通过喷雾干燥过程实现了分层结构形成的有前途的建筑套件。为了详细表征材料的结构和力学性能,采用汞侵入和扫描电镜进行了研究。利用纳米压痕技术系统研究了悬浮液的配方参数(初级粒径和模板含量)对聚集体结构微观力学性能的影响,以阐明结构-性能之间的关系,例如弹性和塑性变形。因此,可以在实验确定的力学参数与聚集体孔隙率之间建立相关性。这种具有明确性质的微观结构可用于各种应用,包括催化或作为药物载体。例如,这些喷雾干燥的聚集体装载了布洛芬作为示例性活性药物成分,并研究了它们的药物释放行为。
{"title":"Micromechanical properties of spray-dried core-shell silica aggregates along with drug release tests","authors":"Matthäus Barasinski ,&nbsp;Carsten Schilde ,&nbsp;Sebastian Melzig ,&nbsp;Merle Hübner ,&nbsp;Georg Garnweitner ,&nbsp;Sabrina Zellmer","doi":"10.1016/j.jciso.2022.100052","DOIUrl":"10.1016/j.jciso.2022.100052","url":null,"abstract":"<div><p>In order to enhance the quality of spray-dried products or to adjust material properties for new applications, precise control of the aggregate structure is desirable. For the purpose of preparing hierarchically structured aggregates in the micrometer range, the formulation of the suspension can be specifically designed, utilizing defined nanoparticulate building blocks to achieve a highly uniform structure and porosity. Further adjustments can be made by combining two types of primary particles that differ in size. Thereby, a segregation effect is observed, where nanoparticles with larger particle sizes accumulate rather within the core of an aggregate and those with smaller particle sizes gather mainly near the outer surface, resulting in the formation of a shell. Furthermore, it is possible to produce tailor-made porosities using template particles (e.g. polystyrene) of different sizes as part of the coarse and fine fractions. The removal of these particles by a subsequent tempering process can lead to aggregates with defined porous structures and thus, to different mechanical aggregate properties that can be specifically set by adjusting the process and formulation parameters. As a result, a promising building kit for the hierarchically structure formation via spray drying processes were achieved.</p><p>For the detailed characterization structural and mechanical material properties were investigated, using e.g. mercury intrusion and SEM. The influence of the formulation parameters of the suspension (primary particle size and template content) on the micromechanical properties of the aggregate structures was systematically investigated by nanoindentation to elucidate structure-property relationships regarding, for example elastic and plastic deformation. As a result, a correlation could be established between the experimentally determined mechanical parameters and the aggregate porosities.</p><p>Such microstructures with defined properties can be used in a variety of applications, including catalysis or as drug carriers. For instance, these spray-dried aggregates were loaded with ibuprofen as an exemplary active pharmaceutical ingredient and investigated with regard to their drug release behavior.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000101/pdfft?md5=08cbe6160eba2117836b718916e5947a&pid=1-s2.0-S2666934X22000101-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44110984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
期刊
JCIS open
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1