D. Velasco, C. Quílez, Marta García, J. F. Cañizo, J. Jorcano
Based on the 3D printing technologies and the concepts developed in tissue engineering during the last decades, 3D bioprinting is emerging as the most innovative and promising technology for the generation of human tissues and organs. In the case of skin bioprinting, thanks to the research process carried out during the last years, interfollicular skin has been printed with a structural and functional quality that paves the way for clinical and industrial applications. This review analyzes the present achievements and the future improvements that this area must bring about if bioprinted skin is to become widely used. We have made an effort to integrate the technological and the biological/biomedical sides of the subject.
{"title":"3D human skin bioprinting: a view from the bio side","authors":"D. Velasco, C. Quílez, Marta García, J. F. Cañizo, J. Jorcano","doi":"10.2217/3DP-2018-0008","DOIUrl":"https://doi.org/10.2217/3DP-2018-0008","url":null,"abstract":"Based on the 3D printing technologies and the concepts developed in tissue engineering during the last decades, 3D bioprinting is emerging as the most innovative and promising technology for the generation of human tissues and organs. In the case of skin bioprinting, thanks to the research process carried out during the last years, interfollicular skin has been printed with a structural and functional quality that paves the way for clinical and industrial applications. This review analyzes the present achievements and the future improvements that this area must bring about if bioprinted skin is to become widely used. We have made an effort to integrate the technological and the biological/biomedical sides of the subject.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90190008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Case presentation of the effects of 3D-printed models on the maternal bonding of two fetuses with facial clefts. Method: In one case the Maternal Antenatal Attachment Scale was used to score maternal bonding before and after viewing of 3D-printed images. In the other case, the effect of the 3D-printed image was witnessed anecdotally. Both 3D prints were created using polylactic acid on an Ultramaker 2+ printer. Result: In both cases maternal bonding appeared to be improved. Increased global bonding and quality of attachment was quantifiably measured in the second case. Conclusion: 3D-printed models can be a useful addition to patient education and can positively impact maternal–fetal bonding. Further study is required to evaluate how 3D printing can affect maternal bonding in a larger setting.
{"title":"Improved maternal bonding with the use of 3D-printed models in the setting of a facial cleft","authors":"J. J. Coté, Brittany Thomas, J. Marvin","doi":"10.2217/3DP-2018-0005","DOIUrl":"https://doi.org/10.2217/3DP-2018-0005","url":null,"abstract":"Aim: Case presentation of the effects of 3D-printed models on the maternal bonding of two fetuses with facial clefts. Method: In one case the Maternal Antenatal Attachment Scale was used to score maternal bonding before and after viewing of 3D-printed images. In the other case, the effect of the 3D-printed image was witnessed anecdotally. Both 3D prints were created using polylactic acid on an Ultramaker 2+ printer. Result: In both cases maternal bonding appeared to be improved. Increased global bonding and quality of attachment was quantifiably measured in the second case. Conclusion: 3D-printed models can be a useful addition to patient education and can positively impact maternal–fetal bonding. Further study is required to evaluate how 3D printing can affect maternal bonding in a larger setting.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76575273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dolores Remedios Serrano Lopez, M. Terres, Katerina Lalatsa
The tumor heterogeneity and interindividual variability is a major problem when treating cancer as every patient responds in a different way to the current drug therapies. 3D printing is a tool that can hamper the issues faced in cancer patients allowing for individualization of treatment by the production of in vitro models with microenvironments mimicking more closely real cancer conditions facilitating complex therapies. Further improvements are required, for example the development of biocompatible bioinks or need for vascularization. The journey from bench to bedside is challenging from the regulatory point of view where the establishment of manufacturing guidelines, quality systems and safety of use and administration of personalized medicines remains unclear. This review will provide an insight into the major applications of 3D printing in cancer both in the development of in vitro cancer models as well as personalized medicines for cancer patients focused on hydrogels and therapeutic implants. [Formula: see text]
{"title":"Applications of 3D printing in cancer","authors":"Dolores Remedios Serrano Lopez, M. Terres, Katerina Lalatsa","doi":"10.2217/3DP-2018-0007","DOIUrl":"https://doi.org/10.2217/3DP-2018-0007","url":null,"abstract":"The tumor heterogeneity and interindividual variability is a major problem when treating cancer as every patient responds in a different way to the current drug therapies. 3D printing is a tool that can hamper the issues faced in cancer patients allowing for individualization of treatment by the production of in vitro models with microenvironments mimicking more closely real cancer conditions facilitating complex therapies. Further improvements are required, for example the development of biocompatible bioinks or need for vascularization. The journey from bench to bedside is challenging from the regulatory point of view where the establishment of manufacturing guidelines, quality systems and safety of use and administration of personalized medicines remains unclear. This review will provide an insight into the major applications of 3D printing in cancer both in the development of in vitro cancer models as well as personalized medicines for cancer patients focused on hydrogels and therapeutic implants. [Formula: see text]","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83269993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fil: Real, Juan Pablo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina
线程:Real, Juan Pablo。国家科学技术研究委员会。Conicet科技中心-科尔多瓦。医药技术研究与开发单位。科尔多瓦国立大学。化学科学学院。医药技术研究与开发单位;阿根廷
{"title":"Modified-release 3D printed tablets: challenges and opportunities based on geometry and materials","authors":"J. Real, N. Camacho, Eugenia Barberis, S. Palma","doi":"10.2217/3DP-2018-0011","DOIUrl":"https://doi.org/10.2217/3DP-2018-0011","url":null,"abstract":"Fil: Real, Juan Pablo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88049223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MeDe innovation fifth annual meeting and 3DMedical expo 2018","authors":"S. Mannan","doi":"10.2217/3DP-2018-0009","DOIUrl":"https://doi.org/10.2217/3DP-2018-0009","url":null,"abstract":"","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73826969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
João B Costa, J. Silva-Correia, R. Reis, J. Oliveira
Fibrocartilage is a very peculiar type of tissue found in intervertebral disc and meniscus. It is characterized by its avascular nature and for the shear and compressive forces that it can be subjected to. The number of individuals affected by the degeneration of fibrocartilaginous tissues has been growing and the poor outcomes of current treatments have led to an increased interest in new alternative approaches. Therefore, the combination of reverse engineering with 3D printing has been extensively explored in order to produce patient-specific implants capable of improving the current clinical outcomes. This review outlines the recent advances achieved in the tissue engineering field, especially focusing on fibrocartilaginous tissue.
{"title":"Recent advances on 3D printing of patient-specific implants for fibrocartilage tissue regeneration","authors":"João B Costa, J. Silva-Correia, R. Reis, J. Oliveira","doi":"10.2217/3DP-2018-0006","DOIUrl":"https://doi.org/10.2217/3DP-2018-0006","url":null,"abstract":"Fibrocartilage is a very peculiar type of tissue found in intervertebral disc and meniscus. It is characterized by its avascular nature and for the shear and compressive forces that it can be subjected to. The number of individuals affected by the degeneration of fibrocartilaginous tissues has been growing and the poor outcomes of current treatments have led to an increased interest in new alternative approaches. Therefore, the combination of reverse engineering with 3D printing has been extensively explored in order to produce patient-specific implants capable of improving the current clinical outcomes. This review outlines the recent advances achieved in the tissue engineering field, especially focusing on fibrocartilaginous tissue.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86122617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01Epub Date: 2017-12-15DOI: 10.2217/3dp-2017-0017
Chelsea L Reighard, Scott J Hollister, David A Zopf
The human ear imparts critical form and function and remains one of the most challenging facial features to reconstruct. Over the past century, surgeons have developed numerous techniques and materials for total auricular reconstruction. Refined costal cartilage techniques have remained the gold standard for the past half-century. Recent advancements with novel materials, tissue engineering and 3D printing provide immense potential; however, prohibitive costs and regulatory steps remain as barriers to clinical translation.
{"title":"Auricular reconstruction from rib to 3D printing.","authors":"Chelsea L Reighard, Scott J Hollister, David A Zopf","doi":"10.2217/3dp-2017-0017","DOIUrl":"10.2217/3dp-2017-0017","url":null,"abstract":"<p><p>The human ear imparts critical form and function and remains one of the most challenging facial features to reconstruct. Over the past century, surgeons have developed numerous techniques and materials for total auricular reconstruction. Refined costal cartilage techniques have remained the gold standard for the past half-century. Recent advancements with novel materials, tissue engineering and 3D printing provide immense potential; however, prohibitive costs and regulatory steps remain as barriers to clinical translation.</p>","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"2 1","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824712/pdf/3dp-02-35.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35967974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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