{"title":"Applications of antimicrobial 3D printing materials in space","authors":"J. Zuniga, Michael Thompson","doi":"10.2217/3DP-2019-0001","DOIUrl":"https://doi.org/10.2217/3DP-2019-0001","url":null,"abstract":"","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73794042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Nukala, S. Palekar, Nayan G Solanki, Yige Fu, Manali Patki, Ali A Sohatee, L. Trombetta, Ketan Patel
Aim: The aim of this work was to investigate the effect of printing pattern on physical attributes and dissolution of fused deposition modeling 3D printed caplets. Methods: Hydrochlorothiazide-loaded polyvinyl alcohol filaments were prepared by hot melt extrusion. Caplets printed in hexagonal (HexCap), diamond infill (DiaCap) in three different sizes using fused deposition modeling 3D printer and evaluated for hardness, disintegration and dissolution. Results: DiaCaps exhibited higher hardness than HexCaps. Disintegration time for HexCaps was <20 mins. while DiaCaps took 25–40 mins. DiaCaps showed 20–30% lower release at all time points compared with HexCaps. Conclusion: Although composition, processing parameters were same, mere change in printing pattern alters disintegration and dissolution. Findings of this study can be invaluable in developing patient-tailored medicines.
{"title":"Investigating the application of FDM 3D printing pattern in preparation of patient-tailored dosage forms","authors":"P. Nukala, S. Palekar, Nayan G Solanki, Yige Fu, Manali Patki, Ali A Sohatee, L. Trombetta, Ketan Patel","doi":"10.2217/3DP-2018-0028","DOIUrl":"https://doi.org/10.2217/3DP-2018-0028","url":null,"abstract":"Aim: The aim of this work was to investigate the effect of printing pattern on physical attributes and dissolution of fused deposition modeling 3D printed caplets. Methods: Hydrochlorothiazide-loaded polyvinyl alcohol filaments were prepared by hot melt extrusion. Caplets printed in hexagonal (HexCap), diamond infill (DiaCap) in three different sizes using fused deposition modeling 3D printer and evaluated for hardness, disintegration and dissolution. Results: DiaCaps exhibited higher hardness than HexCaps. Disintegration time for HexCaps was <20 mins. while DiaCaps took 25–40 mins. DiaCaps showed 20–30% lower release at all time points compared with HexCaps. Conclusion: Although composition, processing parameters were same, mere change in printing pattern alters disintegration and dissolution. Findings of this study can be invaluable in developing patient-tailored medicines.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89766810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Journal of 3D Printing in Medicine Foreword","authors":"M. Gregg","doi":"10.2217/3DP-2018-0029","DOIUrl":"https://doi.org/10.2217/3DP-2018-0029","url":null,"abstract":"","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72864540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Chameettachal, S. Sasikumar, S. Sethi, Yeleswarapu Sriya, Falguni Pati
Tissue/organ-derived bioink formulations open up new avenues in 3D bioprinting research with the potential to create functional tissue or organs. Printing of tissue construct largely depends on material properties, as it needs to be fabricated in an aqueous environment while encapsulating living cells. The decellularized extracellular matrix bioinks proved to be a potential option for functional tissue development in vivo and as an alternative to chemically cross-linked bioinks. However, certain limitations such as printability and limited mechanical strength need to be addressed for enhancing their widespread applications. By drawing knowledge from the existing literature, emphasis has been given in this review to the development of decellularized extracellular matrix bioinks and their applications in printing functional tissue constructs.
{"title":"Tissue/organ-derived bioink formulation for 3D bioprinting","authors":"S. Chameettachal, S. Sasikumar, S. Sethi, Yeleswarapu Sriya, Falguni Pati","doi":"10.2217/3DP-2018-0024","DOIUrl":"https://doi.org/10.2217/3DP-2018-0024","url":null,"abstract":"Tissue/organ-derived bioink formulations open up new avenues in 3D bioprinting research with the potential to create functional tissue or organs. Printing of tissue construct largely depends on material properties, as it needs to be fabricated in an aqueous environment while encapsulating living cells. The decellularized extracellular matrix bioinks proved to be a potential option for functional tissue development in vivo and as an alternative to chemically cross-linked bioinks. However, certain limitations such as printability and limited mechanical strength need to be addressed for enhancing their widespread applications. By drawing knowledge from the existing literature, emphasis has been given in this review to the development of decellularized extracellular matrix bioinks and their applications in printing functional tissue constructs.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82476251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Koti, Narine Muselimyan, Eman Mirdamadi, H. Asfour, N. Sarvazyan
Aim To 3D print heart tissue, one must understand how the main two types of cardiac cells are affected by the printing process. Materials & methods Effects of gelatin methacryloyl (GelMA) concentration, extruder pressure and duration of UV exposure on survival of cardiac myocytes and fibroblasts were examined using lactate dehydrogenase and LIVE/DEAD assays, bioluminescence imaging and morphological assessment. Results & conclusion Cell survival within 3D printed cardiomyocyte-laden GelMA constructs was more sensitive to extruder pressure and GelMA concentrations than within 3D fibroblast-laden GelMA constructs. Cells within both types of constructs were adversely impacted by the UV curing step. Use of mixed cell populations and enrichment of bioink formulation with fibronectin led to an improvement of cardiomyocyte survival and spreading.
{"title":"Use of GelMA for 3D printing of cardiac myocytes and fibroblasts.","authors":"P. Koti, Narine Muselimyan, Eman Mirdamadi, H. Asfour, N. Sarvazyan","doi":"10.2217/3DP-2018-0017","DOIUrl":"https://doi.org/10.2217/3DP-2018-0017","url":null,"abstract":"Aim\u0000To 3D print heart tissue, one must understand how the main two types of cardiac cells are affected by the printing process.\u0000\u0000\u0000Materials & methods\u0000Effects of gelatin methacryloyl (GelMA) concentration, extruder pressure and duration of UV exposure on survival of cardiac myocytes and fibroblasts were examined using lactate dehydrogenase and LIVE/DEAD assays, bioluminescence imaging and morphological assessment.\u0000\u0000\u0000Results & conclusion\u0000Cell survival within 3D printed cardiomyocyte-laden GelMA constructs was more sensitive to extruder pressure and GelMA concentrations than within 3D fibroblast-laden GelMA constructs. Cells within both types of constructs were adversely impacted by the UV curing step. Use of mixed cell populations and enrichment of bioink formulation with fibronectin led to an improvement of cardiomyocyte survival and spreading.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"56 1","pages":"11-22"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86032331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioprinting neural tissues using stem cells as a tool for screening drug targets for Alzheimer’s disease","authors":"S. Willerth","doi":"10.2217/3DP-2018-0016","DOIUrl":"https://doi.org/10.2217/3DP-2018-0016","url":null,"abstract":"","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80984641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David R. Rutkowski, D. Sun, P. Anderson, A. Roldán-Alzate
Aim: This study aims to detail an interactive process to design, fabricate and test patient-specific drill templates and surgical training models, and to determine the advantages and disadvantages of multiple low-cost additive manufacturing methods in this application. Materials & methods: Image data from one patient were used to develop and manufacture both patient-specific drill templates for spinal surgery and replica spine models for surgical training with three, low-cost additive manufacturing methods. With the input of an orthopedic surgeon, the models were analyzed based on function, production time, cost, durability and appearance. Results & conclusion: Although differences were observed in the spinal surgery training models, the performance of the drill template models showed little variance across fabrication methods and template materials.
{"title":"A method to design and manufacture low-cost patient-specific templates for spinal surgery: evaluation of multiple additive manufacturing methods","authors":"David R. Rutkowski, D. Sun, P. Anderson, A. Roldán-Alzate","doi":"10.2217/3DP-2018-0019","DOIUrl":"https://doi.org/10.2217/3DP-2018-0019","url":null,"abstract":"Aim: This study aims to detail an interactive process to design, fabricate and test patient-specific drill templates and surgical training models, and to determine the advantages and disadvantages of multiple low-cost additive manufacturing methods in this application. Materials & methods: Image data from one patient were used to develop and manufacture both patient-specific drill templates for spinal surgery and replica spine models for surgical training with three, low-cost additive manufacturing methods. With the input of an orthopedic surgeon, the models were analyzed based on function, production time, cost, durability and appearance. Results & conclusion: Although differences were observed in the spinal surgery training models, the performance of the drill template models showed little variance across fabrication methods and template materials.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88683338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
3D bioprinting has steadily evolved and a variety of relevant research applications are being pursued in conjunction with recent advances in 3D bioprinting. 3D bioprinting facilitates the creation of physiologically relevant geometries and complex structures through precise spatial control of cells and biomaterials. One such development is known as bioink, a type of cell-encapsulation material that recapitulates the extracellular matrix. In this review, we provide an in-depth assessment of the 3D bioprinting technologies and bioinks that have been employed to date in the field of therapeutics and tissue engineering. We further discuss the latest achievements of 3D bioprinting in integumental, musculoskeletal and otolaryngological applications, as well as future perspectives for 3D bioprinting technologies.
{"title":"3D bioprinting technologies and bioinks for therapeutic and tissue engineering applications","authors":"Yeong-Jin Choi, J. Park, Jinah Jang, D. Cho","doi":"10.2217/3DP-2018-0014","DOIUrl":"https://doi.org/10.2217/3DP-2018-0014","url":null,"abstract":"3D bioprinting has steadily evolved and a variety of relevant research applications are being pursued in conjunction with recent advances in 3D bioprinting. 3D bioprinting facilitates the creation of physiologically relevant geometries and complex structures through precise spatial control of cells and biomaterials. One such development is known as bioink, a type of cell-encapsulation material that recapitulates the extracellular matrix. In this review, we provide an in-depth assessment of the 3D bioprinting technologies and bioinks that have been employed to date in the field of therapeutics and tissue engineering. We further discuss the latest achievements of 3D bioprinting in integumental, musculoskeletal and otolaryngological applications, as well as future perspectives for 3D bioprinting technologies.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78927791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The 3D printing is a developing technology which has begun to flourish in fields where the ability to visualize complex anatomy in novel ways can aid interventions. This paper reviews the literature on 3D printing in cardiac surgery. Methods: We performed a literature search in three databases using appropriate search terms to capture publications pertaining to 3D printing in cardiac surgery. Results: Our search demonstrated a paucity of literature in this area, with 27 relevant publications identified since 1980. The majority of articles pertained to the utility of 3D printing in presurgical planning, but its application in other areas was largely unexplored. Conclusion: There is enormous potential for growth of 3D printing in cardiac surgery, which can drastically change the way, we practice medicine.
{"title":"Innovations in cardiac surgery: techniques and applications of 3D printing","authors":"Judy Wang, J. Coles-Black, G. Matalanis, J. Chuen","doi":"10.2217/3DP-2018-0013","DOIUrl":"https://doi.org/10.2217/3DP-2018-0013","url":null,"abstract":"Aim: The 3D printing is a developing technology which has begun to flourish in fields where the ability to visualize complex anatomy in novel ways can aid interventions. This paper reviews the literature on 3D printing in cardiac surgery. Methods: We performed a literature search in three databases using appropriate search terms to capture publications pertaining to 3D printing in cardiac surgery. Results: Our search demonstrated a paucity of literature in this area, with 27 relevant publications identified since 1980. The majority of articles pertained to the utility of 3D printing in presurgical planning, but its application in other areas was largely unexplored. Conclusion: There is enormous potential for growth of 3D printing in cardiac surgery, which can drastically change the way, we practice medicine.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75863682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taciana Pereira, Margaret E. Prendergast, Ricky Solorzano
Bone tissue engineering is a field whose relevance is paramount, especially for the treatment of musculoskeletal-related disabilities. Failure of conventional methods to create physiologically relevant bone materials has prompted exploring several 3D-printing and additive manufacturing processes, including bioprinting, selective laser sintering, electrospinning and stereolithography. These technologies emerged in conjunction with new materials such as Hyperelastic Bone™, graphene and thermoplastics coupled with cell-laden hydrogels. This work will review these current state-of-the-art materials and technologies, their impact on advancements in bone tissue engineering and will highlight future considerations for the field.
{"title":"State of the art biofabrication technologies and materials for bone tissue engineering","authors":"Taciana Pereira, Margaret E. Prendergast, Ricky Solorzano","doi":"10.2217/3DP-2018-0003","DOIUrl":"https://doi.org/10.2217/3DP-2018-0003","url":null,"abstract":"Bone tissue engineering is a field whose relevance is paramount, especially for the treatment of musculoskeletal-related disabilities. Failure of conventional methods to create physiologically relevant bone materials has prompted exploring several 3D-printing and additive manufacturing processes, including bioprinting, selective laser sintering, electrospinning and stereolithography. These technologies emerged in conjunction with new materials such as Hyperelastic Bone™, graphene and thermoplastics coupled with cell-laden hydrogels. This work will review these current state-of-the-art materials and technologies, their impact on advancements in bone tissue engineering and will highlight future considerations for the field.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79222860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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