Advances in neurobiology最新文献

The structural complexity of brain tumor tissue represents a major challenge for effective histopathological diagnosis. Tumor vasculature is known to be heterogeneous, and mixtures of patterns are usually present. Therefore, extracting key descriptive features for accurate quantification is not a straightforward task. Several steps are involved in the texture analysis process where tissue heterogeneity contributes to the variability of the results. One of the interesting aspects of the brain lies in its fractal nature. Many regions within the brain tissue yield similar statistical properties at different scales of magnification. Fractal-based analysis of the histological features of brain tumors can reveal the underlying complexity of tissue structure and angiostructure, also providing an indication of tissue abnormality development. It can further be used to quantify the chaotic signature of disease to distinguish between different temporal tumor stages and histopathological grades.Brain meningioma subtype classifications' improvement from histopathological images is the main focus of this chapter. Meningioma tissue texture exhibits a wide range of histological patterns whereby a single slide may show a combination of multiple patterns. Distinctive fractal patterns quantified in a multiresolution manner would be for better spatial relationship representation. Fractal features extracted from textural tissue patterns can be useful in characterizing meningioma tumors in terms of subtype classification, a challenging problem compared to histological grading, and furthermore can provide an objective measure for quantifying subtle features within subtypes that are hard to discriminate.

The introduction of fractal geometry to the neurosciences has been a major paradigm shift over the last decades as it has helped overcome approximations and limitations that occur when Euclidean and reductionist approaches are used to analyze neurons or the entire brain. Fractal geometry allows for quantitative analysis and description of the geometric complexity of the brain, from its single units to the neuronal networks.As illustrated in the second section of this book, fractal analysis provides a quantitative tool for the study of the morphology of brain cells (i.e., neurons and microglia) and its components (e.g., dendritic trees, synapses), as well as the brain structure itself (cortex, functional modules, neuronal networks). The self-similar logic which generates and shapes the different hierarchical systems of the brain and even some structures related to its "container," that is, the cranial sutures on the skull, is widely discussed in the following chapters, with a link between the applications of fractal analysis to the neuroanatomy and basic neurosciences to the clinical applications discussed in the third section.

In this chapter, the personal journey of the author in many countries, including Italy, Germany, Austria, the United Kingdom, Switzerland, the United States, Canada, and Australia, is summarized, aimed to merge different translational fields (such as neurosurgery and the clinical neurosciences in general, biomedical engineering, mathematics, computer science, and cognitive sciences) and lay the foundations of a new field defined computational neurosurgery, with fractals, pattern recognition, memetics, and artificial intelligence as the common key words of the journey.

When neurons are recruited to form the memory engram, they are driven to activate the expression of a series of immediate-early genes (IEGs). While these IEGs have been used relatively indiscriminately to identify the so-called engram neurons, recent research has demonstrated that different IEG ensembles can be physically and functionally distinct within the memory engram. This inherent heterogeneity of the memory engram is driven by the diversity in the functions and distributions of different IEGs. This process, which we call molecular sorting, is analogous to sorting the entire population of engram neurons into different sub-engrams molecularly defined by different IEGs. In this chapter, we will describe the molecular sorting process by systematically reviewing published work on engram ensemble cells defined by the following four major IEGs: Fos, Npas4, Arc, and Egr1. By comparing and contrasting these likely different components of the memory engram, we hope to gain a better understanding of the logic and significance behind the molecular sorting process for memory functions.

Astrocytes, a major class of glial cells, are an important element at the synapse where they engage in bidirectional crosstalk with neurons to regulate numerous aspects of neurotransmission, circuit function, and behavior. Mutations in synapse-related genes expressed in both neurons and astrocytes are central factors in a vast number of neurological disorders, making the proteins that they encode prominent targets for therapeutic intervention. Yet, while the roles of many of these synaptic proteins in neurons are well established, the functions of the same proteins in astrocytes are largely unknown. This gap in knowledge must be addressed to refine therapeutic approaches. In this chapter, we integrate multiomic meta-analysis and a comprehensive overview of current literature to show that astrocytes express an astounding number of genes that overlap with the neuronal and synaptic transcriptomes. Further, we highlight recent reports that characterize the expression patterns and potential novel roles of these genes in astrocytes in both physiological and pathological conditions, underscoring the importance of considering both cell types when investigating the function and regulation of synaptic proteins.

Visual patterns reflect the anatomical and cognitive background underlying process governing how we perceive information, influenced by stimulus characteristics and our own visual perception. These patterns are both spatially complex and display self-similarity seen in fractal geometry at different scales, making them challenging to measure using the traditional topological dimensions used in Euclidean geometry.However, methods for measuring eye gaze patterns using fractals have shown success in quantifying geometric complexity, matchability, and implementation into machine learning methods. This success is due to the inherent capabilities that fractals possess when reducing dimensionality using Hilbert curves, measuring temporal complexity using the Higuchi fractal dimension (HFD), and determining geometric complexity using the Minkowski-Bouligand dimension.Understanding the many applications of fractals when measuring and analyzing eye gaze patterns can extend the current growing body of knowledge by identifying markers tied to neurological pathology. Additionally, in future work, fractals can facilitate defining imaging modalities in eye tracking diagnostics by exploiting their capability to acquire multiscale information, including complementary functions, structures, and dynamics.

Depression is currently one of the most complicated public health problems with the rising number of patients, increasing partly due to pandemics, but also due to increased existential insecurities and complicated aetiology of disease. Besides the tsunami of mental health issues, there are limitations imposed by ambiguous clinical rules of assessment of the symptoms and obsolete and inefficient standard therapy approaches. Here we are summarizing the neuroimaging results pointing out the actual complexity of the disease and novel attempts to detect depression that are evidence-based, mostly related to electrophysiology. It is repeatedly shown that the complexity of resting-state EEG recorded in patients suffering from depression is increased compared to healthy controls. We are discussing here how that can be interpreted and what we can learn about future effective therapies. Also, there is evidence that novel options of treatment, like different modalities of electromagnetic stimulation, are successful just because they are capable of decreasing that aberrated complexity. And complexity measures extracted from electrophysiological signals of depression patients can serve as excellent features for further machine learning models in order to automatize detection. In addition, after initial detection and even selection of responders for further therapy route, it is possible to monitor the therapeutic flow for one person, which leads us to possible tailored treatment for patients suffering from depression.

The characteristics of biomedical signals are not captured by conventional measures like the average amplitude of the signal. The methodologies derived from fractal geometry have been a very useful approach to study the degree of irregularity of a signal. The monofractal analysis of a signal is defined by a single power-law exponent in assuming a scale invariance in time and space. However, temporal and spatial variation in the scale-invariant structure of the biomedical signal often appears. In this case, multifractal analysis is well-suited because it is defined by a multifractal spectrum of power-law exponents. There are several approaches to the implementation of this analysis, and there are numerous ways to present these.In this chapter, we review the use of multifractal analysis for the purpose of characterizing signals in neuroimaging. After describing the tenets of multifractal analysis, we present several approaches to estimating the multifractal spectrum. Finally, we describe the applications of this spectrum on biomedical signals in the characterization of several diseases in neurosciences.

Brain tumor detection is crucial for clinical diagnosis and efficient therapy. In this work, we propose a hybrid approach for brain tumor classification based on both fractal geometry features and deep learning. In our proposed framework, we adopt the concept of fractal geometry to generate a "percolation" image with the aim of highlighting important spatial properties in brain images. Then both the original and the percolation images are provided as input to a convolutional neural network to detect the tumor. Extensive experiments, carried out on a well-known benchmark dataset, indicate that using percolation images can help the system perform better.

The endogenous opioid system (EOS) is complex. The line of research contributing to our current body of knowledge about this system is diverse, as are the ways in which endogenous opioids affect human health and behavior. This chapter serves as an introduction to the edited volume. It includes commentary about the current public discourse related to opioids, the rationale for this book, and the unique contributions of each chapter within this volume.