Over the past decade, there has been a growing concern over invasion of Florida Gulf Coastal Waters and beaches by several algal blooms created by “red tides”. These algal blooms create various toxins that pose high risks for marine life, livestock, birds, and humans [1, 2]. The algae become so numerous that they discolor gulf waters and beaches. Since the 1980’s, red tides have been seen in many countries throughout the globe (i.e., South America, Central America, Japan, caribbean, South Pacific regions, etc.).
{"title":"Red Tide: Why a Biologic, HDFx, and Magnesium Could be used to allay Inflammatory and Lung Problems Caused by Algal Blooms: Hypothesis","authors":"","doi":"10.33140/jcei.06.01.03","DOIUrl":"https://doi.org/10.33140/jcei.06.01.03","url":null,"abstract":"Over the past decade, there has been a growing concern over invasion of Florida Gulf Coastal Waters and beaches by several algal blooms created by “red tides”. These algal blooms create various toxins that pose high risks for marine life, livestock, birds, and humans [1, 2]. The algae become so numerous that they discolor gulf waters and beaches. Since the 1980’s, red tides have been seen in many countries throughout the globe (i.e., South America, Central America, Japan, caribbean, South Pacific regions, etc.).","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85998997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The onset of worldwide contamination of an unknown subject brought a lot of fear around the world. The first thought was that reducing of interpersonal distance and reduction of travelling would undermine contamination. Rather quickly the origin of the evil in the form of a Covid-19 virus became clearer after energetic investigation in only several weeks. Rapidly it has been decided that a vaccination would be helpful to attack the problem.
{"title":"What we learned from the Covid-19 Outbreak in 2020","authors":"","doi":"10.33140/jcei.06.01.02","DOIUrl":"https://doi.org/10.33140/jcei.06.01.02","url":null,"abstract":"The onset of worldwide contamination of an unknown subject brought a lot of fear around the world. The first thought was that reducing of interpersonal distance and reduction of travelling would undermine contamination. Rather quickly the origin of the evil in the form of a Covid-19 virus became clearer after energetic investigation in only several weeks. Rapidly it has been decided that a vaccination would be helpful to attack the problem.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75652936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A small particle of the size about 100 micrometers (SARS-V2) has shaken the world. In some Covid-19 patients a severe immune reaction was found in which cells release too many cytokines into the blood too quickly. Cytokines are regulators of host responses to infection, immune responses, inflammation, and trauma. In addition, cytokines activate those cells, stimulating them to produce more cytokines. Normally, this feedback loop is kept in check by the body. Some cytokines act to make disease worse. Cytokine storms might explain why some people have a severe reaction to corona viruses while others only experience mild symptoms. They could also be the reason why younger people are less affected, as their immune systems are less developed and so produce lower levels of inflammation-driving cytokines. Since, in early 2020, Covid -19 became pandemic, globally multi-pronged research started to get rid of corona virus 2 (SARSCoV-2) [1, 2]. For such a task, it was necessary to understand the pathogenesis of covid-19, due to the fact that SARS-CoV-2, is new and its mechanism of action and its interrelationship with the human body organs is not fully known yet. Nevertheless, it is known that all viruses and bacteria when invade the body interact with the immune system, inflammation starts and if the immune system cannot get rid of the invaders, pathogenesis starts.
{"title":"Cytokines: The Game Changer in Pathogenesis of Covid-19","authors":"","doi":"10.33140/jcei.06.01.01","DOIUrl":"https://doi.org/10.33140/jcei.06.01.01","url":null,"abstract":"A small particle of the size about 100 micrometers (SARS-V2) has shaken the world. In some Covid-19 patients a severe immune reaction was found in which cells release too many cytokines into the blood too quickly. Cytokines are regulators of host responses to infection, immune responses, inflammation, and trauma. In addition, cytokines activate those cells, stimulating them to produce more cytokines. Normally, this feedback loop is kept in check by the body. Some cytokines act to make disease worse. Cytokine storms might explain why some people have a severe reaction to corona viruses while others only experience mild symptoms. They could also be the reason why younger people are less affected, as their immune systems are less developed and so produce lower levels of inflammation-driving cytokines. Since, in early 2020, Covid -19 became pandemic, globally multi-pronged research started to get rid of corona virus 2 (SARSCoV-2) [1, 2]. For such a task, it was necessary to understand the pathogenesis of covid-19, due to the fact that SARS-CoV-2, is new and its mechanism of action and its interrelationship with the human body organs is not fully known yet. Nevertheless, it is known that all viruses and bacteria when invade the body interact with the immune system, inflammation starts and if the immune system cannot get rid of the invaders, pathogenesis starts.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"13 42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80561045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Coronavirus (SARS-CoV-2) made the headlines after its initial breakout in Wahan, China in December 2019. Viral by genome, lethal by nature, strongly contagious by character succeeded in making a new chapter in everyone’s life in a very short span making it a pandemic Objectives: The aim of this study was to assess perceptional disparity among dental practitioners regarding the Coronavirus Disease 2019 (COVID-2019) pandemic. Material and methods: A total of 300 participating dentists were randomly included in this cross sectional survey. A self structured, closed ended questionnaire was administered to each participant to record demographic and professional characteristics followed by their knowledge regarding corona virus. Statistical analysis was performed using SPSS Version 20 and Multivariable linear regression analysis was carried out Results: It was found that only 33.3% of the clinicians had high knowledge regarding corona virus and only 38.5% of the respondents know the correct incubation period. About 65 % of the practitioners did not know about the diagnostic test available for corona virus and only 4.3 % of them gained knowledge rom journals or print media The above responses indicate a low knowledge among the dental practitioners regarding corona virus. Conclusions: The knowledge and practice scores were found to be worrisome, which is important to combat COVID-19. They are advised to follow the Centers of Disease Control and Prevention (CDC) and World Health Organization (WHO) guidelines in their clinics, and sensitize their staff so that no stone is left unturned in defeating this pandemic.
背景:冠状病毒(SARS-CoV-2)于2019年12月在中国武汉首次爆发后，成为头条新闻。基因组病毒，本质上致命，本质上具有强烈传染性，成功地在很短的时间内为每个人的生活谱写了新篇章，使其成为一场大流行。目的:本研究的目的是评估牙科医生对2019冠状病毒病(COVID-2019)大流行的感知差异。材料与方法:随机抽取300名参与调查的牙医进行横断面调查。每位参与者都填写了一份自结构的封闭式问卷，记录人口统计学和专业特征，以及他们对冠状病毒的了解。采用SPSS Version 20进行统计分析，并进行多变量线性回归分析。结果:只有33.3%的临床医生对冠状病毒有较高的知识，只有38.5%的应答者知道正确的潜伏期。约65%的执业医师不知道可用的冠状病毒诊断测试，只有4.3%的执业医师从期刊或印刷媒体获得相关知识。上述反应表明牙科执业医师对冠状病毒的了解程度较低。结论:知识和实践成绩令人担忧，这对抗击新冠肺炎具有重要意义。在诊所应遵循美国疾病控制与预防中心(CDC)和世界卫生组织(WHO)的指导方针，并提高工作人员的敏感性，以便不遗余力地战胜这次大流行。
{"title":"COVID-19 Perceptional Disparity Among Dental Practitioners in Tricity (Chandigarh, Panchkula and Mohali)","authors":"","doi":"10.33140/jcei.06.01.04","DOIUrl":"https://doi.org/10.33140/jcei.06.01.04","url":null,"abstract":"Background: Coronavirus (SARS-CoV-2) made the headlines after its initial breakout in Wahan, China in December 2019. Viral by genome, lethal by nature, strongly contagious by character succeeded in making a new chapter in everyone’s life in a very short span making it a pandemic Objectives: The aim of this study was to assess perceptional disparity among dental practitioners regarding the Coronavirus Disease 2019 (COVID-2019) pandemic. Material and methods: A total of 300 participating dentists were randomly included in this cross sectional survey. A self structured, closed ended questionnaire was administered to each participant to record demographic and professional characteristics followed by their knowledge regarding corona virus. Statistical analysis was performed using SPSS Version 20 and Multivariable linear regression analysis was carried out Results: It was found that only 33.3% of the clinicians had high knowledge regarding corona virus and only 38.5% of the respondents know the correct incubation period. About 65 % of the practitioners did not know about the diagnostic test available for corona virus and only 4.3 % of them gained knowledge rom journals or print media The above responses indicate a low knowledge among the dental practitioners regarding corona virus. Conclusions: The knowledge and practice scores were found to be worrisome, which is important to combat COVID-19. They are advised to follow the Centers of Disease Control and Prevention (CDC) and World Health Organization (WHO) guidelines in their clinics, and sensitize their staff so that no stone is left unturned in defeating this pandemic.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90711603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-10-20DOI: 10.33140/jcei.06.05.04
Swarupa Pahan, Sridevi Dasarathi, Kalipada Pahan
Cinnamon is a regularly used natural seasoning and flavoring material throughout the world for eras. Recent laboratory studies have demonstrated that oral cinnamon may be beneficial for different neuroinflammatory and neurodegenerative disorders such as multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body diseases (LBD). However, cinnamon's certain limitations (e.g. unavailability of true Ceylon cinnamon throughout the world, impurities in ground cinnamon, etc.) have initiated an interest among researchers to find an alternate of cinnamon that can potentially deliver the same efficacy in the diseases mentioned above. Glyceryl tribenzoate (GTB) is a U.S. Food and Drug Administration (FDA)-approved flavoring ingredient that is used in food and food packaging industries. It has been found that similar to cinnamon, oral GTB is capable of upregulating regulatory T cells and suppressing the autoimmune disease process of experimental autoimmune encephalomyelitis, an animal model of MS. Moreover, both GTB and cinnamon metabolite sodium benzoate (NaB) have the potency to attenuate neurodegenerative pathology in a mouse model of Huntington disease (HD). Here, we have also demonstrated anti-inflammatory property of GTB in astrocytes and macrophages, a property that is also seen with cinnamon and its metabolite sodium benzoate (NaB). Therefore, here, we have made a sincere attempt to discuss the similarities and dissimilarities between cinnamon and GTB with a focus whether GTB has the potential to be considered as a substitute of cinnamon for neuroinflammatory and neurodegenerative disorders.
{"title":"Glyceryl tribenzoate: A food additive with unique properties to be a substitute for cinnamon.","authors":"Swarupa Pahan, Sridevi Dasarathi, Kalipada Pahan","doi":"10.33140/jcei.06.05.04","DOIUrl":"https://doi.org/10.33140/jcei.06.05.04","url":null,"abstract":"<p><p>Cinnamon is a regularly used natural seasoning and flavoring material throughout the world for eras. Recent laboratory studies have demonstrated that oral cinnamon may be beneficial for different neuroinflammatory and neurodegenerative disorders such as multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body diseases (LBD). However, cinnamon's certain limitations (e.g. unavailability of true Ceylon cinnamon throughout the world, impurities in ground cinnamon, etc.) have initiated an interest among researchers to find an alternate of cinnamon that can potentially deliver the same efficacy in the diseases mentioned above. Glyceryl tribenzoate (GTB) is a U.S. Food and Drug Administration (FDA)-approved flavoring ingredient that is used in food and food packaging industries. It has been found that similar to cinnamon, oral GTB is capable of upregulating regulatory T cells and suppressing the autoimmune disease process of experimental autoimmune encephalomyelitis, an animal model of MS. Moreover, both GTB and cinnamon metabolite sodium benzoate (NaB) have the potency to attenuate neurodegenerative pathology in a mouse model of Huntington disease (HD). Here, we have also demonstrated anti-inflammatory property of GTB in astrocytes and macrophages, a property that is also seen with cinnamon and its metabolite sodium benzoate (NaB). Therefore, here, we have made a sincere attempt to discuss the similarities and dissimilarities between cinnamon and GTB with a focus whether GTB has the potential to be considered as a substitute of cinnamon for neuroinflammatory and neurodegenerative disorders.</p>","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"6 5","pages":"367-372"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555914/pdf/nihms-1749969.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39581006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
From coral to coal. A course from life to decay; from fluid plasticity to sedimentary rigidity; from tropical reef polyps expansion to combustible oxidative free radicals reaction; from expression to suppression; from flourish to perish. All these contrasting dynamics, this vivid antithesis of an integer ecosystem to a compressed peat bog, this endless colorful miracle of delight to a blackish stratum shell of scorn, get to be defined by a single letter; an “r”. The reflection that stands in between and makes all the difference; the reflection that stands in between and as a pivotal criterion reverberates opposed conditions and qualities; the reflection that stands in between and as a sword decides and divides. Which way it will be: light or darkness, real or unreal, allostasis or allostatic load, neuroinflammation or neuroprotection, progressive neurodegeneration or cell control and communication, gamma synchrony or hyperexcitability, well-being or mind-body infirmity, is determined by a serious consideration and careful thought. The conceptual operation of inverting a system or event with respect to a plane. A level of existence and cogitation, or development in accordance with a vectoring, a direction, orientation and attention. And for all the above, the mind-eye mirror connection which perceives and interprets, and creates a neuronal abstract substrate of bound distinct circuits that form as a whole memory, undoubtedly holds the key.
{"title":"From Coral to Coal","authors":"","doi":"10.33140/jcei.05.06.03","DOIUrl":"https://doi.org/10.33140/jcei.05.06.03","url":null,"abstract":"From coral to coal. A course from life to decay; from fluid plasticity to sedimentary rigidity; from tropical reef polyps expansion to combustible oxidative free radicals reaction; from expression to suppression; from flourish to perish. All these contrasting dynamics, this vivid antithesis of an integer ecosystem to a compressed peat bog, this endless colorful miracle of delight to a blackish stratum shell of scorn, get to be defined by a single letter; an “r”. The reflection that stands in between and makes all the difference; the reflection that stands in between and as a pivotal criterion reverberates opposed conditions and qualities; the reflection that stands in between and as a sword decides and divides. Which way it will be: light or darkness, real or unreal, allostasis or allostatic load, neuroinflammation or neuroprotection, progressive neurodegeneration or cell control and communication, gamma synchrony or hyperexcitability, well-being or mind-body infirmity, is determined by a serious consideration and careful thought. The conceptual operation of inverting a system or event with respect to a plane. A level of existence and cogitation, or development in accordance with a vectoring, a direction, orientation and attention. And for all the above, the mind-eye mirror connection which perceives and interprets, and creates a neuronal abstract substrate of bound distinct circuits that form as a whole memory, undoubtedly holds the key.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78949882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To evaluate the safety and efficacy of transcutaneous vagus nerve stimulation in preventing respiratory failure and improving survival in hospitalized COVID-19 patients. Design, Setting, and Participants: Interim analysis of an ongoing single-arm, uncontrolled open-label, observational trial to assess the transcutaneous vagus nerve stimulation (tVNS) in hospitalized SARS-CoV-2 infected subjects. Eligible subjects are 18 years old or older requiring hospitalization for COVID-19pneumonia. Results: The 25 subjects enrolled with a mean age of 52.2 (22-80). Mechanical ventilation was required in only 2 (8%) cases. One survived and 1 one died. Although 4 (16%) of the 25 hospitalized subjects died, only 1 (4%) was attributed to respiratory failure. Relative to other reported COVID-19 hospitalization outcomes data, our mortality rate of 16% (4 of 25) is lower than many other reported cohorts 10.2% – 50%. Only 8% (2 of 25) of subjects required mechanical ventilation comparing favorably to 7.4%-79% of subjects requiring mechanical ventilation in other cohorts. Adverse events associated with tVNS occurred in only 2 subjects (8%) and consisted of reversible oral paresthesia and orthostatic hypotension. Conclusion and Relevance: In this interim report of tVNS in COVID-19 pneumonia, patients had a low rate of adverse events, infrequent use of mechanical ventilation, and a high rate of survival. Several other studies have shown a wide range of in hospital mortality (14-50%) and the requirement of mechanical ventilation (7-79%). The interim analysis found the mortality rate and the frequency of mechanical ventilation to be less than almost all other large COVID-19 cohorts. Only mild and self-limiting adverse events tVNS occurred in 2 subjects highlighting the safety of vagus stimulation. The study is slated to enroll a minimum of 50 subjects. Trial Registration: ClinicalTrials.gov Identifier: NTC04379037.
{"title":"Transcutaneous Vagus Nerve Stimulation is Associated with Lower Mechanical Ventilation and Mortality in COVID-19 Patients: An interim Safety Analysis","authors":"P. Nemechek","doi":"10.33140/jcei.05.06.02","DOIUrl":"https://doi.org/10.33140/jcei.05.06.02","url":null,"abstract":"Objective: To evaluate the safety and efficacy of transcutaneous vagus nerve stimulation in preventing respiratory failure and improving survival in hospitalized COVID-19 patients. Design, Setting, and Participants: Interim analysis of an ongoing single-arm, uncontrolled open-label, observational trial to assess the transcutaneous vagus nerve stimulation (tVNS) in hospitalized SARS-CoV-2 infected subjects. Eligible subjects are 18 years old or older requiring hospitalization for COVID-19pneumonia. Results: The 25 subjects enrolled with a mean age of 52.2 (22-80). Mechanical ventilation was required in only 2 (8%) cases. One survived and 1 one died. Although 4 (16%) of the 25 hospitalized subjects died, only 1 (4%) was attributed to respiratory failure. Relative to other reported COVID-19 hospitalization outcomes data, our mortality rate of 16% (4 of 25) is lower than many other reported cohorts 10.2% – 50%. Only 8% (2 of 25) of subjects required mechanical ventilation comparing favorably to 7.4%-79% of subjects requiring mechanical ventilation in other cohorts. Adverse events associated with tVNS occurred in only 2 subjects (8%) and consisted of reversible oral paresthesia and orthostatic hypotension. Conclusion and Relevance: In this interim report of tVNS in COVID-19 pneumonia, patients had a low rate of adverse events, infrequent use of mechanical ventilation, and a high rate of survival. Several other studies have shown a wide range of in hospital mortality (14-50%) and the requirement of mechanical ventilation (7-79%). The interim analysis found the mortality rate and the frequency of mechanical ventilation to be less than almost all other large COVID-19 cohorts. Only mild and self-limiting adverse events tVNS occurred in 2 subjects highlighting the safety of vagus stimulation. The study is slated to enroll a minimum of 50 subjects. Trial Registration: ClinicalTrials.gov Identifier: NTC04379037.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75272720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In past several months, the worldwide outbreak of COVID-19 infection is unstoppable, which results in millions of people infected and thousands of people dead. However, there are still something controversial in the virus mechanism, the epidemiological feature and the diagnose criterion of COVID-19, while we also have some consensus. The structure of SARS-CoV-2, the pathogen of COVID-19, is roughly similar with other coronavirus such as SARS-CoV and bat-CoV, but by sequencing the amino acid, recombination of virus particles, and observation in Electron microscope, it is obvious to find the some slight difference between the protein of SARS-CoV-2 and others’. The spike protein of SARSCoV-2 has a stronger ability to binding ACE2 than SARS-CoV. The carrier of SARS-CoV-2 is just as other respiratory viruses, like droplet, aerosol and surface, and the fecal-oral transmission is proved to be an efficient pathway. In clinical practice, the elder and the patients with comorbidity are more susceptible to infection and have poorer prognosis, while pediatric patients is the very opposite of it. Nucleic acid test represented by RT-PCR is a helpful method for diagnose, yet it has weaknesses of false negative in suspicious patient and resurgence in discharge patient. Serological and immunological test, reported not suitable for diagnose alone in early period, can be another reliable method that benefit the accuracy of diagnosis criterion when combined with RT-PCR.
{"title":"Features of Pathogens, Epidemiology, and Diagnosis of COVID-19 and Reliable\u0000Suggestion: Aiming to Solve the Confusion in Clinical Practice","authors":"","doi":"10.33140/jcei.05.05.003","DOIUrl":"https://doi.org/10.33140/jcei.05.05.003","url":null,"abstract":"In past several months, the worldwide outbreak of COVID-19 infection is unstoppable, which results in millions of\u0000people infected and thousands of people dead. However, there are still something controversial in the virus mechanism,\u0000the epidemiological feature and the diagnose criterion of COVID-19, while we also have some consensus. The structure\u0000of SARS-CoV-2, the pathogen of COVID-19, is roughly similar with other coronavirus such as SARS-CoV and bat-CoV,\u0000but by sequencing the amino acid, recombination of virus particles, and observation in Electron microscope, it is\u0000obvious to find the some slight difference between the protein of SARS-CoV-2 and others’. The spike protein of SARSCoV-2 has a stronger ability to binding ACE2 than SARS-CoV. The carrier of SARS-CoV-2 is just as other respiratory\u0000viruses, like droplet, aerosol and surface, and the fecal-oral transmission is proved to be an efficient pathway. In\u0000clinical practice, the elder and the patients with comorbidity are more susceptible to infection and have poorer\u0000prognosis, while pediatric patients is the very opposite of it. Nucleic acid test represented by RT-PCR is a helpful\u0000method for diagnose, yet it has weaknesses of false negative in suspicious patient and resurgence in discharge patient.\u0000Serological and immunological test, reported not suitable for diagnose alone in early period, can be another reliable\u0000method that benefit the accuracy of diagnosis criterion when combined with RT-PCR.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80467707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In past several months, the worldwide outbreak of COVID-19 infection is unstoppable, which results in millions of people infected and thousands of people dead. However, there are still something controversial in the virus mechanism, the epidemiological feature and the diagnose criterion of COVID-19, while we also have some consensus. The structure of SARS-CoV-2, the pathogen of COVID-19, is roughly similar with other coronavirus such as SARS-CoV and bat-CoV, but by sequencing the amino acid, recombination of virus particles, and observation in Electron microscope, it is obvious to find the some slight difference between the protein of SARS-CoV-2 and others’. The spike protein of SARSCoV-2 has a stronger ability to binding ACE2 than SARS-CoV. The carrier of SARS-CoV-2 is just as other respiratory viruses, like droplet, aerosol and surface, and the fecal-oral transmission is proved to be an efficient pathway. In clinical practice, the elder and the patients with comorbidity are more susceptible to infection and have poorer prognosis, while pediatric patients is the very opposite of it. Nucleic acid test represented by RT-PCR is a helpful method for diagnose, yet it has weaknesses of false negative in suspicious patient and resurgence in discharge patient. Serological and immunological test, reported not suitable for diagnose alone in early period, can be another reliable method that benefit the accuracy of diagnosis criterion when combined with RT-PCR.
{"title":"Features of Pathogens, Epidemiology, and Diagnosis of COVID-19 and Reliable Suggestion: Aiming to Solve the Confusion in Clinical Practice","authors":"","doi":"10.33140/jcei.05.05.03","DOIUrl":"https://doi.org/10.33140/jcei.05.05.03","url":null,"abstract":"In past several months, the worldwide outbreak of COVID-19 infection is unstoppable, which results in millions of people infected and thousands of people dead. However, there are still something controversial in the virus mechanism, the epidemiological feature and the diagnose criterion of COVID-19, while we also have some consensus. The structure of SARS-CoV-2, the pathogen of COVID-19, is roughly similar with other coronavirus such as SARS-CoV and bat-CoV, but by sequencing the amino acid, recombination of virus particles, and observation in Electron microscope, it is obvious to find the some slight difference between the protein of SARS-CoV-2 and others’. The spike protein of SARSCoV-2 has a stronger ability to binding ACE2 than SARS-CoV. The carrier of SARS-CoV-2 is just as other respiratory viruses, like droplet, aerosol and surface, and the fecal-oral transmission is proved to be an efficient pathway. In clinical practice, the elder and the patients with comorbidity are more susceptible to infection and have poorer prognosis, while pediatric patients is the very opposite of it. Nucleic acid test represented by RT-PCR is a helpful method for diagnose, yet it has weaknesses of false negative in suspicious patient and resurgence in discharge patient. Serological and immunological test, reported not suitable for diagnose alone in early period, can be another reliable method that benefit the accuracy of diagnosis criterion when combined with RT-PCR.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85655996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In time, the wrong choice of words, along with faulty behavioural settings (errors), can influence one’s emotional and physical responses negatively. Lifestyle errors can act like bad sectors or clusters. The terms “bad sector” and “bad cluster” refer to a specific section of a digital storage device that has been rendered unusable for reading and writing data. When a computer says it has found bad sectors or clusters, it means that it has identified part of a connected storage medium that it can’t access. The computer can attempt to recover data that is stored on bad sectors and clusters, but there is a chance the data is lost forever.
{"title":"What is on a mouth’s mind?","authors":"","doi":"10.33140/jcei.05.05.06","DOIUrl":"https://doi.org/10.33140/jcei.05.05.06","url":null,"abstract":"In time, the wrong choice of words, along with faulty behavioural settings (errors), can influence one’s emotional and physical responses negatively. Lifestyle errors can act like bad sectors or clusters. The terms “bad sector” and “bad cluster” refer to a specific section of a digital storage device that has been rendered unusable for reading and writing data. When a computer says it has found bad sectors or clusters, it means that it has identified part of a connected storage medium that it can’t access. The computer can attempt to recover data that is stored on bad sectors and clusters, but there is a chance the data is lost forever.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86289475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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