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A Framework for Designing Efficient Eco-Friendly Broadband GeSn/SnS Photodetector Based on Light Trapping Engineering 基于光捕获工程的高效环保型宽带 GeSn/SnS 光电探测器设计框架
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-01 DOI: 10.1007/s11468-024-02440-z
H. Ferhati, F. Djeffal

A multispectral photoresponse feature of a self-powered photodetector device is quickly becoming a key technology to address the scaling challenges in emerging multifunctional optoelectronic systems. The heterostructure of different materials has opened new pathways to design broadband self-driven photoresponse using a single device. In this work, a new multispectral photodetector based on SnS/GeSn heterostructure with optimized gold nanoparticles is proposed. Moreover, broadband photodetector performances are improved by using a new design framework based on coupling particle swarm optimization approach and plasmonic effects. Numerical models based on the finite difference time domain method are carried out. A broadband photodetection is achieved in a single SnS/GeSn heterostructured photodetector with optimized surface gold nanoparticles, with a high on/off ratio of 160 dB, improved responsivity of 8.5 A/W and specific detectivity of over 5 × 1012 Jones in the self-powered mode. Therefore, the proposed design framework based on the strategic combination between SnS/GeSn heterostructure and optimized gold nanoparticles array provides new paths and efficient strategy to enhance the optoelectronic performance of broadband photodetectors by exploiting the light trapping engineering combined with band-gap tuning aspects.

自供电光电探测器设备的多光谱光响应特性正迅速成为解决新兴多功能光电系统扩展难题的关键技术。不同材料的异质结构为利用单一器件设计宽带自驱动光响应开辟了新的途径。本研究提出了一种基于 SnS/GeSn 异质结构和优化金纳米粒子的新型多光谱光电探测器。此外,通过使用基于粒子群优化方法和等离子效应耦合的新设计框架,宽带光电探测器的性能得到了提高。基于有限差分时域法的数值模型得以实现。采用优化表面金纳米粒子的单个 SnS/GeSn 异质结构光电探测器实现了宽带光电探测,具有 160 dB 的高导通/关断比,响应率提高到 8.5 A/W,自供电模式下的比探测率超过 5 × 1012 Jones。因此,基于 SnS/GeSn 异质结构与优化的金纳米粒子阵列之间的策略性结合而提出的设计框架,为利用光捕获工程与带隙调谐相结合的方法来提高宽带光电探测器的光电性能提供了新的途径和有效的策略。
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引用次数: 0
Design of Encoded and Tunable Graphene-Gold Metasurface-Based Surface Plasmon Resonance Sensors for Glucose Detection in the Terahertz Regime 设计基于石墨烯-金元表面的编码和可调谐表面等离子体共振传感器,用于太赫兹区葡萄糖检测
IF 3.3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-07-31 DOI: 10.1007/s11468-024-02452-9
N. K. Anushkannan, Jacob Wekalao, Shobhit K. Patel, Fahad Ahmed Al-Zahrani

This study presents the design, optimization, and evaluation of a highly sensitive terahertz refractive index sensor utilizing graphene metasurfaces for glucose detection in urine samples. The proposed sensor incorporates circular, square, and triangular resonator structures composed of graphene, gold, and silver to enhance plasmonic properties and sensing performance. Comprehensive parametric analysis and optimization were conducted using COMSOL Multiphysics simulations. The sensor demonstrates excellent performance characteristics, including a high sensitivity of 1000 GHzRIU−1 and quality factors ranging from 100.2 to 100.5. To further improve accuracy and reduce simulation time, an XGBoost Regressor model was integrated for predicting sensor behaviour across various parameters. The model achieved R2 scores consistently at or near 1, validating the robustness of the sensor design. Comparative analysis with existing literature highlights the superior sensitivity, figure of merit, and quality factor of the proposed sensor. This work contributes to advancing non-invasive glucose monitoring technologies and demonstrates the potential of machine learning integration in optimizing metamaterial-based sensors for biomedical applications.

本研究介绍了一种利用石墨烯元表面的高灵敏度太赫兹折射率传感器的设计、优化和评估,该传感器用于尿液样本中的葡萄糖检测。拟议的传感器采用了由石墨烯、金和银组成的圆形、方形和三角形谐振器结构,以增强等离子特性和传感性能。利用 COMSOL 多物理场仿真进行了全面的参数分析和优化。传感器表现出卓越的性能特征,包括 1000 GHzRIU-1 的高灵敏度和 100.2 至 100.5 的品质因数。为了进一步提高精度和缩短仿真时间,我们集成了一个 XGBoost 回归模型,用于预测传感器在不同参数下的行为。该模型的 R2 值始终保持在 1 或接近 1,验证了传感器设计的稳健性。与现有文献的对比分析表明,所提出的传感器具有更高的灵敏度、优越性和品质因数。这项工作有助于推动无创葡萄糖监测技术的发展,并展示了机器学习集成在优化生物医学应用中基于超材料的传感器方面的潜力。
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引用次数: 0
Synthesis and Characterization of Double Core-shell Au@Ag@Au Nanoparticles by Pulsed Laser Ablation in Liquid and Analysis of Their Antibacterial Properties 利用脉冲激光烧蚀液态双核壳 Au@Ag@Au 纳米粒子的合成与表征及其抗菌特性分析
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-07-31 DOI: 10.1007/s11468-024-02450-x
Ahmed A. Aktafa, Uday M. Nayef, Majid S. Jabir

Our research involved the synthesis of a double core-shell structure using gold and silver NPs. The core material used was gold. The initial shell had a silver coating, while the subsequent shell was encased in gold. The wavelength of the laser was 1046 nm and was employed, along with 250 pulses at a frequency of 1 Hz, delivering an energy of 500 mJ into 5 ml of deionized water; the focal length of the lens was 12 cm. A comparison was made between the double core-shell construction consisting of individual silver (Ag) and gold (Au) nanoparticles and the single core-shell structure. Various tests were conducted on the samples, including XRD, TEM, UV-visible, FTIR, and zeta potential, to analyze their characteristics. Additionally, the energy gap was determined for each sample. Next, the study examined the impact of particles with a double core-shell and single particles on S. aureus and E. coli bacteria. The findings revealed that a double coating exhibited exceptional effectiveness in eliminating bacterial cells when compared to single particles and a single core-shell. This was demonstrated through the implementation of a zone of inhibition and antibiofilm activity. They were able to verify the existence of the two metal substances (Au and Ag) in each and every sample by using X-ray diffraction (XRD). TEM images clearly depict the formation of the core-shell system. Also presented were TEM images of colloidal particles made of gold and silver, which were smaller than 10 nm in size. The formation of certain nanoparticles resulted in a shift in the peak wavelength, confirming the occurrence of a superficial overlap. The energy transition was calculated using the Tauc relation, with specific values for the different nanoparticles involved. Based on the zeta potential, it is observed that the stability of Ag NPs is greater than that of Au NPs. Additionally, the core double-shell structure formed is found to be less stable compared to the individual Au NPs and Ag NPs. During the ICP-MS analysis, it was observed that the amount of the double shells reduced in comparison to both the individual shell and the individual gold and silver particles. The particles were linked to each other to produce the shells. The current study suggested the potential role of Au@Ag@Au NPs for antibacterial applications in the future.

我们的研究涉及使用金和银 NPs 合成双核壳结构。使用的核心材料是金。最初的外壳有一层银涂层,而随后的外壳则由金包裹。激光波长为 1046 nm,使用频率为 1 Hz 的 250 个脉冲,将 500 mJ 的能量注入 5 ml 去离子水中;透镜焦距为 12 cm。对由单个银(Ag)和金(Au)纳米粒子组成的双核壳结构和单核壳结构进行了比较。对样品进行了各种测试,包括 XRD、TEM、UV-visible、FTIR 和 zeta 电位,以分析其特性。此外,还测定了每个样品的能隙。接下来,研究还考察了双核壳颗粒和单颗粒对金黄色葡萄球菌和大肠杆菌的影响。研究结果表明,与单颗粒和单核壳相比,双涂层在消除细菌细胞方面表现出卓越的功效。抑制区和抗生物膜活性的实施证明了这一点。他们利用 X 射线衍射 (XRD) 验证了每个样品中都存在两种金属物质(金和银)。TEM 图像清楚地描述了核壳系统的形成。此外,还展示了尺寸小于 10 纳米的金银胶体颗粒的 TEM 图像。某些纳米粒子的形成导致了峰值波长的移动,证实了表面重叠的发生。能量转换是通过陶克关系计算得出的,不同的纳米粒子有不同的数值。根据 zeta 电位观察到,Ag NPs 的稳定性高于 Au NPs。此外,与单个 Au NPs 和 Ag NPs 相比,形成的核心双壳结构稳定性较差。在 ICP-MS 分析过程中观察到,与单个外壳和单个金银粒子相比,双壳的数量减少了。颗粒之间相互连接,从而产生了外壳。目前的研究表明,Au@Ag@Au NPs 在未来的抗菌应用中具有潜在的作用。
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引用次数: 0
Resonant Excitation of Terahertz Surface Plasmons by Optical Rectification Over a Rippled Graphene Surface 通过波纹石墨烯表面的光学整流共振激发太赫兹表面等离子体
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-07-30 DOI: 10.1007/s11468-024-02437-8
Rohit Kumar Srivastav

Resonant excitation of terahertz surface plasmons by optical rectification over rippled graphene surface, deposited on (text {SiO}_{2}) using a mode conversion of amplitude modulated p-polarized laser beam. A pump surface plasmons exert a ponderomotive force on the free electrons of the graphene surface and impart a linear oscillatory velocity at the modulation frequency. The current density develops by coupling the linear oscillatory velocity with modulated electron density and resonantly excites the terahertz surface plasmons at the modulation frequency. The amplitude of terahertz surface plasmons can be tunable by Fermi energy of graphene surface (text {E}_text {F}). There is a possibility that the current study will be used to utilize THz detectors and sensors.

利用振幅调制对偏振激光束的模式转换,通过波纹石墨烯表面的光学整流共振激发太赫兹表面等离子体。泵浦表面等离子体对石墨烯表面的自由电子产生思索动力,并在调制频率下产生线性振荡速度。线性振荡速度与调制电子密度耦合产生电流密度,并在调制频率下共振激发太赫兹表面质子。太赫兹表面等离子体的振幅可以通过石墨烯表面的费米能(text {E}_text {F})进行调谐。目前的研究有可能被用于太赫兹探测器和传感器。
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引用次数: 0
Self-Referential Plasmonic Refractive Index Sensor by Square Hole Array and Gold Film Coupling Structure 采用方孔阵列和金膜耦合结构的自反射质子折射率传感器
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-07-30 DOI: 10.1007/s11468-024-02420-3
Xijun Rao, Huirong Zhu, Xiangxian Wang, Yizhen Chen, Yunping Qi, Hua Yang

A surface plasmonic refractive index (RI) sensor is proposed based on a square hole array and gold film coupling structure. This sensor enables high-sensitivity sensing with self-reference characteristics in gas and liquid environments. The reflectance spectrum and electric fields are calculated using a finite-difference time-domain (FDTD) method. Meanwhile, the cases of rotating square-hole arrays and changing the incident light of the polarization direction are discussed, respectively. The results show that the varying polarization direction of the incident light does not affect the reflectance spectrum of the composite structure. Rotating the array of square holes further enhances the signal strength of the resonance modes excited by the proposed sensor. The sensor has two resonance modes with different functions: one for self-reference and the other for sensing. In the sensing mode, the sensor sensitivity is 1037 and 1063 nm/RIU in gas and liquid environments, respectively; whereas in self-reference mode, the sensitivity decreases to 0 and 21 nm/RIU in gas and liquid environments, respectively. The sensor has a maximum figure of merit (FOM) of 103 RIU-1. These characteristics realize a highly sensitive sensors with a high FOM and self-reference capabilities, which are advantageous for bioassay detection applications.

基于方孔阵列和金膜耦合结构,提出了一种表面等离子体折射率(RI)传感器。该传感器可在气体和液体环境中实现具有自参考特性的高灵敏度传感。利用有限差分时域(FDTD)方法计算了反射光谱和电场。同时,分别讨论了旋转方孔阵列和改变入射光偏振方向的情况。结果表明,改变入射光的偏振方向不会影响复合结构的反射光谱。旋转方孔阵列可进一步增强拟议传感器激发的共振模式的信号强度。该传感器有两种不同功能的共振模式:一种用于自参考,另一种用于传感。在传感模式下,传感器在气体和液体环境中的灵敏度分别为 1037 和 1063 nm/RIU;而在自参考模式下,传感器在气体和液体环境中的灵敏度分别降至 0 和 21 nm/RIU。传感器的最大优点系数(FOM)为 103 RIU-1。这些特性实现了高灵敏度传感器的高 FOM 值和自参考能力,有利于生物分析检测应用。
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引用次数: 0
Enhancing Spectral Responsivity of Zinc Oxide Nanoparticles via Laser Ablation on Porous Silicon 通过激光烧蚀多孔硅增强氧化锌纳米粒子的光谱响应性
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-07-30 DOI: 10.1007/s11468-024-02456-5
Salah M. Abdul Aziz, Uday M. Nayef, Mohammed Rasheed

In this research, the production of zinc oxide nanoparticles (ZnO NPs) was made using various pulsed laser ablation energy (PLA) embedded in substrates made up of porous silicon (PS). The PS substrates were created using the photoelectrochemical etching (PECE) technique of Si n-type (111). The research examined the impact of pulse laser ablation energy for some features on the prepared samples that involved the structural, electrical, optical, and morphological properties in photodetector application. XRD analysis reveals a broad diffraction peak at an angle of 28.4° for the porous silicon with other diffraction peaks at different angles, indicating the presence of the ZnO NPs phase corresponding to the structure of hexagonal wurtzite. The SEM image demonstrates that PS is sponge-like, while ZnO NPs display randomly dispersed spherical grains. The optical characteristics of the fabricated specimens were analyzed using photoluminescence and UV-vis absorption spectroscopy. It was observed that an increase in laser pulse energy results in a shift of the absorption wavelengths and a change in the energy gap. The J-V characteristics of the created specimens were analyzed under two conditions: in dark and light while varying the laser pulse energy. The photodetectors consisting of ZnO NPs/PS/n-Si exhibited rectifying characteristics and remarkable responsivity to a wide range of wavelengths, from UV to near-infrared. Furthermore, the constructed photodetectors exhibited enhanced quantum efficiency (Q.E), specifically in the ultraviolet (UV) range. The results of this research are significant in the progress of optoelectronic and photodetector devices that rely on ZnO NPs and PS.

在这项研究中,利用嵌入多孔硅(PS)基底的各种脉冲激光烧蚀能量(PLA)生产了氧化锌纳米粒子(ZnO NPs)。多孔硅衬底是利用硅 n 型(111)的光电化学蚀刻(PECE)技术制作的。研究考察了脉冲激光烧蚀能量对所制备样品某些特征的影响,这些特征涉及光电探测器应用中的结构、电气、光学和形貌特性。XRD 分析表明,多孔硅在 28.4°角处有一个宽衍射峰,其他衍射峰的角度各不相同,这表明存在与六方菱锰矿结构相对应的 ZnO NPs 相。SEM 图像显示 PS 呈海绵状,而 ZnO NPs 则显示出随机分散的球形晶粒。使用光致发光和紫外-可见吸收光谱分析了制备试样的光学特性。结果表明,激光脉冲能量的增加会导致吸收波长的移动和能隙的变化。在两种条件下分析了所制作试样的 J-V 特性:黑暗和光照,同时改变激光脉冲能量。由 ZnO NPs/PS/n-Si 组成的光电探测器表现出整流特性,并对从紫外到近红外的各种波长具有显著的响应性。此外,所构建的光电探测器还显示出更高的量子效率(Q.E),尤其是在紫外线(UV)范围内。这项研究成果对于依赖氧化锌氮氧化物和 PS 的光电和光电探测器设备的发展具有重要意义。
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引用次数: 0
Biosynthesized Graphene Oxide Nanoparticles: In-Vitro Comparative Study for Biomedical Applications 生物合成的氧化石墨烯纳米颗粒:用于生物医学应用的体外比较研究
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-07-30 DOI: 10.1007/s11468-024-02433-y
Inas S. Mohammed, Duaa Hammoud, Sajidah H. Alkhazraji, Kareem H. Jawad, Buthenia A. Hasoon, Ali Abdullah Issa, Majid S. Jabir

Graphene-based materials have been the subject of extensive research due to its exceptional ability to kill a diverse array of microorganisms. The benefits of graphene-based materials include ease of fabrication, renewable resources, special catalytic properties, and remarkable physical properties including tensile strength and a large specific surface area. Our study utilizes an environmental method (laser production) to produce GONPs. GONPs are tested as potential; this study assesses the molecular docking simulation, anti-microbial, against clinically pathogenic strains of Klebsiella pneumoniae and Bacillus cereus. Antioxidant by DPPH assay and anti-cancer properties of graphene nanoparticles (GONPs) with Doxorubicin on lung cancer (A549 cell line). TEM images demonstrated types of produced GO-NP spherical nanoparticles with a size ranging at approximately 15–40 nm. Atomic force microscopy (AFM) was used to examine the morphological and topological characteristics of the NPs. The structural and crystal characteristics were examined by X-ray diffraction (XRD). Among the anti-bacterial-evaluated GONPs, concentrations of 100, 50, and 25 µg/ml exhibited the most substantial growth inhibition zone against Klebsiella pneumoniae and Bacillus cereus. The molecular docking simulation of GONP-OH modified gave more effective results against Bacillus cereus bacterial organism (ID: 5V8D) and (ID: 5GT6). Conversely, the highest anti-biofilm activity was observed against Bacillus cereus than Klebsiella pneumoniae, notably with 100 µg/ml GONPs. On the toxicity examination of cancer cells, the impact of nanoparticles was investigated. The produced nanoparticles had a higher cytotoxicity rate. The cytotoxicity of GONP alone, Doxorubicin alone, and/or combination therapy (GONP + Doxorubicin) found to be in 25 µg/ml concentration and time dependent manner also increased as combination therapy. The analysis for cell cytotoxicity revealed a noteworthy decrease in the number of cancer cells after GONP + Doxorubicin were treated for 72 h. The average cell cytotoxicity of GONP +Doxorubicin were 54, 61.31, and 76.41% for 24, 48, and 72 h, respectively. Both GONPs exhibited higher cell toxicity and cell death contract control. Additional GONPs showed strong antioxidant properties by DPPH assay. The present research demonstrates the advantageous effectiveness of a simpler production procedure, like laser production, for producing high-purity nanoparticles with low hazard that may be utilized as future possible cancer therapies.

石墨烯基材料具有杀死各种微生物的特殊能力,因此一直是广泛研究的主题。石墨烯基材料的优点包括易于制造、资源可再生、具有特殊的催化特性,以及包括抗拉强度和大比表面积在内的显著物理特性。我们的研究利用一种环保方法(激光生产)来生产 GONPs。本研究评估了分子对接模拟、抗微生物、抗临床致病性肺炎克雷伯氏菌和蜡样芽孢杆菌菌株的潜力。石墨烯纳米颗粒(GONPs)的 DPPH 抗氧化性和多柔比星对肺癌(A549 细胞系)的抗癌特性。TEM 图像显示了所制备的 GO-NP 球形纳米粒子的类型,其大小约为 15-40 纳米。原子力显微镜(AFM)用于检查 NPs 的形态和拓扑特征。X 射线衍射(XRD)检查了结构和晶体特征。在经过抗菌评估的 GONPs 中,浓度为 100、50 和 25 µg/ml 的 GONPs 对肺炎克雷伯氏菌和蜡样芽孢杆菌的生长抑制面积最大。分子对接模拟结果表明,改性 GONP-OH 对蜡样芽孢杆菌(ID:5V8D)和(ID:5GT6)的抑制效果更好。相反,与肺炎克雷伯菌相比,100 µg/ml GONPs 对蜡样芽孢杆菌的抗生物膜活性最高。在癌细胞毒性检测方面,研究了纳米颗粒的影响。生产的纳米粒子具有更高的细胞毒性。研究发现,单用 GONP、单用多柔比星和/或联合疗法(GONP + 多柔比星)的细胞毒性浓度为 25 微克/毫升,而且随着时间的推移,联合疗法的细胞毒性也会增加。细胞毒性分析表明,在 GONP + 多柔比星治疗 72 小时后,癌细胞数量显著减少。GONP + 多柔比星在 24、48 和 72 小时内的平均细胞毒性分别为 54%、61.31% 和 76.41%。两种 GONP 的细胞毒性和细胞死亡率均高于对照组。通过 DPPH 检测,其他 GONPs 还显示出很强的抗氧化性。本研究表明,激光生产等更简单的生产程序在生产高纯度、低危害的纳米粒子方面具有优势,可用作未来可能的癌症疗法。
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引用次数: 0
Design and Optimization of a MXene-Based Terahertz Surface Plasmon Resonance Sensor for Malaria Detection 设计和优化用于疟疾检测的基于 MXene 的太赫兹表面等离子体共振传感器
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-07-29 DOI: 10.1007/s11468-024-02455-6
Haitham Alsaif, Jacob Wekalao, Naim Ben Ali, Omar Kahouli, Jaganathan Logeshwaran, Shobhit K. Patel, Ammar Armghan

Developing sensitive and specific methods for detecting malaria is a substantial challenge in biomedical research. Here, we introduce a novel approach utilizing a metasurface sensor based on graphene for the detection of malaria. Modelled on a silicon dioxide (SiO2) substrate, this sensor allows seamless integration with current electronic and optical technologies. The sensor design incorporates square and quadrant-based resonators, optimized through comprehensive parametric analysis to assess their geometric effects on sensor performance. The results demonstrate an enhanced sensitivity of 600 GHzRIU−1. Analysis of the electric field illustrates frequency-dependent transmittance properties, alongside promising 2-bit encoding capabilities. Furthermore, the research establishes a direct correlation between resonance frequency, refractive index, and analyte concentration. This sensor offers a promising avenue for swift, precise, and non-invasive malaria detection, potentially enhancing point-of-care diagnostic capabilities in healthcare settings.

开发灵敏而特异的疟疾检测方法是生物医学研究的一大挑战。在此,我们介绍一种利用基于石墨烯的元表面传感器检测疟疾的新方法。这种传感器以二氧化硅(SiO2)基底为模型,可与当前的电子和光学技术无缝集成。传感器设计采用了方形和象限谐振器,并通过综合参数分析进行了优化,以评估它们对传感器性能的几何影响。结果表明,灵敏度提高了 600 GHzRIU-1。对电场的分析表明了随频率变化的透射特性,以及有望实现的 2 位编码能力。此外,研究还确定了共振频率、折射率和分析物浓度之间的直接相关性。这种传感器为快速、精确和无创的疟疾检测提供了一个前景广阔的途径,有可能提高医疗机构的床旁诊断能力。
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引用次数: 0
Design and Development of Surface Plasmon Resonance Biosensor for Early Detection of Cervical Cancer Utilizing Nucleus and Cytoplasm 利用细胞核和细胞质设计和开发用于早期检测宫颈癌的表面等离子体共振生物传感器
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-07-27 DOI: 10.1007/s11468-024-02441-y
Trupti Kamani, Shobhit K. Patel, N. K. Anushkannan, Sana ben Khalifa, Saleh Chebaane, Taoufik Saidani

Cervical cancer is a significant risk to women’s lives, and early detection is crucial to secure patient quality of life. Currently, doctors’ diagnosis relies on their subjective assessments, as there is no standardized measuring method. The problem can be solved with the optical biosensor as it provides precise and quick consequences in the determination of cancerous cells. This manuscript presents a novel double c-shaped copper-based refractivity biosensor (DCSCRIB) for the recognition of cervical nucleus as well as cervical cytoplasm cells. The double c-shaped copper-based resonator provides high spatial resolution, upper sensitivity, and upper-quality factor making them for novel choice to detect the nucleus and cytoplasm of cervical cancer. The upper sensitivity (S) has been spotted at 1600 nm/RIU for the cervical nucleus with the upper-quality factor (QF) being 1618.37 for the cervical cytoplasm. The upper rate of the figure of merit (FOM) is 1107.18, the detection area (DR) rate is 1925.17, the signal noise ratio (SNR) rate is 33.2155, and the sensor resolution (SR) rate is 0.93 which has been spotted of cervical cytoplasm. The upper detection limit of 0.0004 has been achieved for the natural cytoplasm. This propounded sensor can highly intellect the cervical cancer biomarkers.

宫颈癌对妇女的生命构成重大威胁,早期发现对确保患者的生活质量至关重要。目前,由于没有标准化的测量方法,医生的诊断主要依靠主观评估。光学生物传感器可以解决这个问题,因为它能精确、快速地确定癌细胞的位置。本手稿介绍了一种新型双 C 形铜基折射率生物传感器(DCSCRIB),用于识别宫颈细胞核和宫颈细胞质。双 c 型铜基谐振器具有高空间分辨率、高灵敏度和高品质因数,是检测宫颈癌细胞核和细胞质的新选择。宫颈癌细胞核的最高灵敏度(S)为 1600 nm/RIU,宫颈癌细胞质的最高品质因数(QF)为 1618.37。宫颈细胞质的优点系数 (FOM) 上限为 1107.18,检测面积 (DR) 上限为 1925.17,信号噪声比 (SNR) 上限为 33.2155,传感器分辨率 (SR) 上限为 0.93。自然细胞质的检测上限为 0.0004。该传感器能高度识别宫颈癌生物标记物。
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引用次数: 0
High-Performance Plasmonic Biosensor for Blood Cancer Detection: Achieving Ultrahigh Figure-of-Merit 用于血癌检测的高性能等离子体生物传感器:实现超高效价比
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-07-27 DOI: 10.1007/s11468-024-02429-8
Yashaswini Singh, Adarsh Chandra Mishra, Sapana Yadav, Laxmi Jaiswal, Pooja Lohia, D. K. Dwivedi, R. K. Yadav, Gaber E. Eldesoky, M. Khalid Hossain

A highly sensitive hybrid structure for biosensing application based on surface plasmon resonance for the detection of blood cancer has been proposed in this article. The biosensor comprises of a CaF2 Prism, Ag metal, an oxide layer Al2O3 and a 2D nanomaterial graphene, which is grounded on Kretschmann configuration. The transfer matrix method is used to interrogate the performance parameters of proposed biosensor. To analyze the change in refractive index, the analyte has been considered over the graphene layer. To achieve maximum sensitivity and minimum reflectance the thickness of Ag, Al2O3 layers and number of graphene layers have been optimized. The suggested structure’s sensitivity can be enhanced up to 427.43 deg/RIU with the optimized value for the detection accuracy and FOM of 0.7027 deg−1 and 217 RIU−1 respectively. The work focuses on the development of plasmonic sensors with high performance and stability. Role of different material layers is also analyzed in terms of enhancement in sensitivity and evanescent field. The paper offers better optimization technique and selection of material than previously reported works, which eventually leads to enhancement in both sensitivity and FOM. This research could lead to the development of a useful biological sample sensing tool for the quick and precise detection of the blood cancer in its early stages.

本文提出了一种基于表面等离子体共振的高灵敏度混合结构生物传感应用,用于检测血癌。该生物传感器由 CaF2 棱镜、银金属、氧化层 Al2O3 和二维纳米材料石墨烯组成,并以 Kretschmann 构型接地。传递矩阵法用于检测拟议生物传感器的性能参数。为了分析折射率的变化,分析物被考虑覆盖在石墨烯层上。为了达到最高灵敏度和最低反射率,对银层、Al2O3 层的厚度和石墨烯层的数量进行了优化。建议结构的灵敏度可提高到 427.43 deg/RIU,检测精度和 FOM 的优化值分别为 0.7027 deg-1 和 217 RIU-1。这项工作的重点是开发具有高性能和高稳定性的等离子体传感器。论文还分析了不同材料层在提高灵敏度和增强蒸发场方面的作用。与以前的研究相比,本文提供了更好的优化技术和材料选择,最终提高了灵敏度和 FOM。这项研究可以开发出一种有用的生物样本传感工具,用于快速、精确地检测早期血癌。
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