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Sensitivity Enhancement in D-Shaped Photonic Crystal Fiber Sensors: Gold Versus Silver Plasmonic Layers D 形光子晶体光纤传感器的灵敏度增强:金与银的等离子层
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-07 DOI: 10.1007/s11468-024-02478-z
Pakarzadeh Hassan, Sharif Vahid, Saberi Hana, Rahmanfar Zahra, Hajivandi Jamileh

Surface plasmon resonance (SPR) sensors have attracted great attention in recent years for various applications such as medical diagnosis and biochemical materials. Among SPR sensors, D-shaped structures based on photonic crystal fibers (PCFs) have shown very high performance and are easy to use. In this paper, a simple design of SPR sensors based on the D-shaped PCFs with the optimized geometrical parameters is proposed. Gold and silver are considered as plasmonic layers on the surface of the D-shaped PCF sensor. By performing multiple simulations using the finite-difference eigenmode (FDE) method, various values of gold and silver thicknesses are investigated to achieve the highest sensitivity and resolution. The results indicate that the highest sensitivity and resolution of 25,600 nm/RIU and (3.9times {10}^{-6}) are achieved respectively for a gold thickness of 44 nm at the analyte refractive index (RI) of 1.41. Meanwhile, for an analyte RI range of 1.29 to 1.40, silver demonstrates greater sensitivity than gold in the same range. The proposed sensor with superior characteristics compared with other SPR sensors can be considered as a very good candidate for RI measurement with high sensitivity, linearity, and resolution.

近年来,表面等离子体共振(SPR)传感器在医疗诊断和生化材料等各种应用领域备受关注。在 SPR 传感器中,基于光子晶体光纤(PCF)的 D 型结构显示出非常高的性能,而且易于使用。本文提出了一种基于 D 型 PCF 的 SPR 传感器的简单设计,并对其几何参数进行了优化。金和银被视为 D 型 PCF 传感器表面的等离子体层。通过使用有限差分特征模式 (FDE) 方法进行多次模拟,研究了各种金银厚度值,以获得最高的灵敏度和分辨率。结果表明,在分析物折射率(RI)为 1.41 时,金厚度为 44 nm 时,灵敏度和分辨率最高,分别为 25,600 nm/RIU 和 (3.9times {10}^{-6})。同时,在分析物折射率为 1.29 至 1.40 的范围内,银的灵敏度高于金。与其他 SPR 传感器相比,所提出的传感器具有更优越的特性,可被视为具有高灵敏度、高线性度和高分辨率的 RI 测量的理想选择。
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引用次数: 0
Enhancing Breast Cancer Biomarker Detection with a Portable Biosensor Utilizing Flower Core Photonic Crystal Fiber Architecture 利用花芯光子晶体光纤架构的便携式生物传感器加强乳腺癌生物标记物检测
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-07 DOI: 10.1007/s11468-024-02470-7
Devika veluchamy, Murugan Senthil Mani Rajan, Yogendra Kumar Prajapati

This study introduces a biosensor utilizing photonic crystal fiber (PCF) technology to detect breast cancer biomarkers. The biosensor features a unique flower core composed of square and circular air holes. The sensing mechanism relies on variations in the resonant wavelength induced by changes in the sample’s concentration or refractive index. As the sample’s concentration increases, the transmission spectrum shifts at higher wavelengths, enabling differentiation between malignant and normal cancer cells. The study demonstrates that the biosensor has achieved its highest recorded sensitivity of 22,069 nm/RIU. Furthermore, comprehensive values to judge the performance are obtained for loss, coupling length, V parameter, propagation constant, amplitude sensitivity, and transmission, in addition to birefringence on the order of 10−5. Thus, the reported biosensor is of high quality and has good potential for sensitive detection of breast cancer. Also, the biosensor presented in this study provides a viable and cost-efficient alternative to molecular biotechnology examination and imaging techniques for the diagnosis of cancer.

本研究介绍了一种利用光子晶体光纤(PCF)技术检测乳腺癌生物标志物的生物传感器。该生物传感器具有一个由方形和圆形气孔组成的独特花芯。其传感机制依赖于样品浓度或折射率变化引起的谐振波长变化。随着样品浓度的增加,透射光谱会向高波长移动,从而区分恶性和正常癌细胞。研究表明,该生物传感器的灵敏度达到了 22069 nm/RIU 的最高记录。此外,还获得了损耗、耦合长度、V 参数、传播常量、振幅灵敏度和透射率的综合值,以及 10-5 数量级的双折射,以判断其性能。因此,报告的生物传感器质量很高,具有灵敏检测乳腺癌的良好潜力。此外,本研究中提出的生物传感器为诊断癌症提供了一种可行的、具有成本效益的分子生物技术检查和成像技术替代方法。
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引用次数: 0
Synthesis of PVA-Gold and Silver Nanoparticles via PLAL to Improve the Performance of the PCF-SPR Glucose Sensor 通过 PLAL 合成 PVA-金和银纳米粒子以提高 PCF-SPR 葡萄糖传感器的性能
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-06 DOI: 10.1007/s11468-024-02434-x
Makram A. Fakhri, Bassam G. Rasheed, Malik J. Abd-Alhussain, Evan T. Salim, Ahmad S. Azzahrani, Ali Basem, Subash C. B. Gopinath

This study proposes a photonic crystal fiber (PCF) biosensor using the surface plasmon resonance (SPR) phenomenon. Active plasmonic nanomaterials, consisting of gold (Au) and silver (Ag) nanoparticles, were prepared via the pulsed laser ablation in liquids (PLAL) method, characterized using different techniques. These nanoparticles were subsequently mixed with a polyvinyl alcohol (PVA) solution to enhance sensitivity and compatibility for sensor applications. The PVA-Au/Ag nanoparticles were coated on the outer surface of the PCF for a simplified sensor configuration. The results showed that the sensitivities for PCF coated with PVA-gold and PVA-silver NPs are 1927 and 1397 nm/RIU with a maximum resolution of 2.51 × 10−5 RIU for samples with glucose concentration in water ranging from 80 to 600 mg/dl and maximum FOM are 853 and 855 for PCF coated with gold and silver NPs, respectively. Notably, this innovative sensor design, coupled with comprehensive nanoparticle characterization and PVA integration, holds great promise for precise and real-time glucose monitoring in many practical applications.

本研究提出了一种利用表面等离子体共振(SPR)现象的光子晶体光纤(PCF)生物传感器。研究人员通过液体脉冲激光烧蚀法(PLAL)制备了由金(Au)和银(Ag)纳米粒子组成的活性等离子体纳米材料,并利用不同的技术对其进行了表征。这些纳米粒子随后与聚乙烯醇(PVA)溶液混合,以提高传感器应用的灵敏度和兼容性。PVA-Au/Ag 纳米粒子被涂覆在 PCF 的外表面,以简化传感器配置。结果表明,在水中葡萄糖浓度为 80 至 600 mg/dl 的样品中,涂有 PVA 金纳米粒子和 PVA 银纳米粒子的 PCF 的灵敏度分别为 1927 和 1397 nm/RIU,最大分辨率为 2.51 × 10-5 RIU;涂有金纳米粒子和银纳米粒子的 PCF 的最大 FOM 分别为 853 和 855。值得注意的是,这种创新的传感器设计,加上全面的纳米粒子表征和 PVA 集成,为许多实际应用中的精确和实时葡萄糖监测带来了巨大的希望。
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引用次数: 0
Silver Nanoparticles for Colorimetric Dual Ion Sensing and Development of Paper Sensors: A Strategy Towards Waste Valorisation and Sustainability 用于比色双离子传感和纸张传感器开发的纳米银颗粒:实现废物价值化和可持续性的策略
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-06 DOI: 10.1007/s11468-024-02431-0
Rugmini R., B. D. Sri Chandana, K. C. Sekhar

Iron and copper are essential for all living organisms, and their balance is crucial as both deficiency and excess can cause health problems. Therefore, this study presents a colorimetric method for detecting Fe3⁺ and Cu2⁺ ions in aqueous samples using silver nanoparticles (AgNPs) synthesised from Ocimum sanctum (Tulasi) leaf extract (TLE). It is observed that AgNPs show optimum plasmonic properties at a precursor-leaf extract ratio of 1:5, reaction temperature of 60 °C and reaction time of 2 h. The AgNPs exhibit the face-centred cubic (fcc) structure and show a surface plasmon resonance peak at 413 nm, hydrodynamic size of 18 ± 5 nm, zeta potential of − 25.5 mV and particle size of 57 nm. FTIR spectra confirm the stabilisation of AgNPs. It is worthy to note that, AgNPs exhibit selective detection of Fe3⁺ and Cu2⁺ over other metal ions and the detection mechanism is proposed based on the reduction potential values. The quantitative detection range for Fe3⁺ and Cu2⁺ are found to be 0–800 μM and 0–600 μM, with the detection limits of 9.1 µM and 19.5 µM, respectively. Additionally, AgNP-based paper sensors for Cu2⁺ detection show qualitative and quantitative colorimetric performance with a detection limit of 23.1 µM. These findings suggest that both AgNPs solution and AgNP-based paper sensors are the potential candidates for metal ion detection.

铁和铜是所有生物体的必需元素,它们之间的平衡至关重要,因为缺乏或过量都会导致健康问题。因此,本研究提出了一种使用银纳米粒子(AgNPs)检测水样中 Fe3⁺和 Cu2⁺离子的比色法,银纳米粒子是由 Ocimum sanctum(Tulasi)叶提取物(TLE)合成的。AgNPs 呈面心立方(fcc)结构,在 413 纳米处显示出表面等离子共振峰,流体力学尺寸为 18 ± 5 纳米,Zeta 电位为 - 25.5 mV,粒径为 57 纳米。傅立叶变换红外光谱证实了 AgNPs 的稳定。值得注意的是,与其他金属离子相比,AgNPs 对 Fe3⁺ 和 Cu2⁺ 的检测具有选择性,其检测机制是基于还原电位值提出的。研究发现,Fe3⁺ 和 Cu2⁺ 的定量检测范围分别为 0-800 μM 和 0-600 μM,检测限分别为 9.1 µM 和 19.5 µM。此外,用于检测 Cu2⁺ 的基于 AgNP 的纸传感器显示出定性和定量的比色性能,检测限为 23.1 µM。这些研究结果表明,AgNPs 溶液和基于 AgNPs 的纸传感器都有可能用于金属离子检测。
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引用次数: 0
Design and Development of High Sensitive Surface Plasmon Resonance Biosensors for Glucose Detection 设计和开发用于葡萄糖检测的高灵敏度表面等离子体共振生物传感器
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-06 DOI: 10.1007/s11468-024-02463-6
Kazi Mustafizur Rahman, Faysal Nayan, Raihan Ahmed, Mushfiqur Rahman

This paper presents a surface plasmon resonance (SPR) sensor utilizing a prism-coupled Ag/ZnSe/BP hybrid structure with improved sensitivity for glucose detection in urine samples. In this Kretschmann configuration, multilayers are vertically stacked together to improve the optical and electronic properties of the proposed SPR sensor. The transfer matrix method (TMM) is used for the theoretical model and to analyze the performance of the sensors. The proposed SPR sensor comprises 2D materials such as black phosphorus (BP), which improve the sensitivity of the SPR-based sensor through efficient interactions with biomolecules. The resonance angle of surface plasmons shifts due to a difference in the refractive index from 1.330 to 1.337 in urine samples with various glucose levels. Initially, the study aims to compare the sensor performance parameters among different prisms (CaF2, BK7, FK51A, and SF10) coupled with a hybrid structure. The proposed sensor achieved a noticeably higher value sensitivity of 511 (deg./RIU), a quality factor of 108.377 (1/RIU), and a figure of merit of 108.374 when a CaF2 prism with an optimized thickness was used. The performance parameters, including the sensitivity, full width at half maximum (FWHM), figure of merit (FoM), and detection accuracy (DA), were measured, and the results were compared to evaluate the findings. The proposed structure can be more effective in detecting different liquid analytes in biosensing applications, including glucose detection.

本文介绍了一种利用棱镜耦合 Ag/ZnSe/BP 混合结构的表面等离子体共振(SPR)传感器,该传感器具有更高的灵敏度,可用于尿液样本中的葡萄糖检测。在这种 Kretschmann 结构中,多层膜垂直堆叠在一起,从而改善了拟议 SPR 传感器的光学和电子特性。传递矩阵法(TMM)用于建立理论模型和分析传感器的性能。拟议的 SPR 传感器由黑磷(BP)等二维材料组成,它们通过与生物分子的有效相互作用提高了基于 SPR 的传感器的灵敏度。在不同葡萄糖含量的尿液样本中,由于折射率从 1.330 到 1.337 的差异,表面等离子体的共振角会发生变化。研究的最初目的是比较不同棱镜(CaF2、BK7、FK51A 和 SF10)与混合结构之间的传感器性能参数。当使用具有优化厚度的 CaF2 棱镜时,拟议传感器的灵敏度明显提高,达到 511 (度/RIU),品质因数为 108.377 (1/RIU),优点系数为 108.374。对灵敏度、半最大全宽(FWHM)、优点系数(FoM)和探测精度(DA)等性能参数进行了测量,并对结果进行了比较和评估。所提出的结构可以更有效地检测生物传感应用中的不同液体分析物,包括葡萄糖检测。
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引用次数: 0
Highly Sensitive PCF-SPR RI Sensor for Cancer Detection Using Gold/Graphene/Ti3C2Tx-MXene Hybrid Layer 使用金/石墨烯/Ti3C2Tx-MXene 混合层的高灵敏 PCF-SPR RI 癌症检测传感器
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-05 DOI: 10.1007/s11468-024-02467-2
Yimin Mao, Fang Ren, Deyang Zhou, Yidan Li

In this paper, a gold/graphene/Ti3C2Tx-MXene hybrid layered D-type photonic crystal fiber (PCF) design based on surface plasmon resonance (SPR) sensors is proposed for cancer cell detection. This design uniquely combines gold, graphene, and Ti3C2Tx-MXene materials to achieve a synergistic effect, significantly enhancing the sensitivity and specificity of the sensor. The full vector finite element method (FVFEM) is used for the entire numerical analysis of the proposed biosensor. The cladding of the D-type PCF has a hexagonal arrangement of air holes. In the first cladding, the two air holes closest to the metal layer are narrowed down to enhance the plasma wave and provide an efficient leakage channel. The last two air holes closest to the metal layer in the same layer are enlarged to limit light scattering and couple more energy to the surface plasmon polariton (SPP) mode. The sensitivity of the sensor improves by using these different diameter air holes and coating the D-type PCF surface with a hybrid gold/graphene/Ti3C2Tx-MXene layer. The geometrical parameters are optimized to obtain higher sensor sensitivity. The corresponding wavelength sensitivities are 3000 nm/RIU for Basal cells, 5000 nm/RIU for HeLa cells (Henrietta Lacks cells), 5714 nm/RIU for Jurkat cells (Human T lymphocyte cells), 7143 nm/RIU for PC12 cells (Pheochromocytoma cells), 8571 nm/RIU for MDA-MB-231 cells (Breast cancer cells), and 9286 nm/RIU for MCF-7 cells (Michigan Cancer Foundation-7, a breast cancer cell line), respectively, confirming the excellent performance of the proposed sensor. The sensor proposed paves the way for efficient, simple, low-cost, and highly sensitive cancer detection techniques that could replace surgical and chemical techniques.

本文提出了一种基于表面等离子体共振 (SPR) 传感器的金/石墨烯/Ti3C2Tx-MXene 混合层状 D 型光子晶体光纤 (PCF) 设计,用于癌细胞检测。该设计独特地结合了金、石墨烯和 Ti3C2Tx-MXene 材料,实现了协同效应,显著提高了传感器的灵敏度和特异性。全矢量有限元法(FVFEM)被用于拟议生物传感器的整个数值分析。D 型 PCF 的包层具有六边形排列的气孔。在第一层包层中,最靠近金属层的两个气孔被缩小,以增强等离子体波并提供有效的泄漏通道。同一层中最靠近金属层的最后两个气孔被扩大,以限制光散射,并将更多能量耦合到表面等离子体极化子(SPP)模式。通过使用这些不同直径的气孔,并在 D 型 PCF 表面镀上金/石墨烯/Ti3C2Tx-MXene 混合层,传感器的灵敏度得到了提高。为了获得更高的传感器灵敏度,对几何参数进行了优化。相应的波长灵敏度分别为:Basal 细胞 3000 nm/RIU;HeLa 细胞(Henrietta Lacks 细胞)5000 nm/RIU;Jurkat 细胞(人类 T 淋巴细胞)5714 nm/RIU;PC12 细胞(嗜铬细胞瘤细胞)7143 nm/RIU、MDA-MB-231 细胞(乳腺癌细胞)的 8571 nm/RIU,以及 MCF-7 细胞(密歇根癌症基金会-7,一种乳腺癌细胞系)的 9286 nm/RIU,证实了所提出传感器的卓越性能。所提出的传感器为高效、简单、低成本和高灵敏度的癌症检测技术铺平了道路,可以取代外科手术和化学技术。
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引用次数: 0
Composite Liquid Media Influence on the Optical and Bactericidal Properties of Silver Nanoparticles Synthesized by Pulsed Laser Ablation in Liquids 复合液体介质对液体中脉冲激光烧蚀合成的银纳米粒子的光学和杀菌特性的影响
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-05 DOI: 10.1007/s11468-024-02443-w
Shahab Ahmed Abbasi, Javeria Javed, Hamza Qayyum, Taj Muhammad Khan, Dilawar Ali, Amjad Iqbal, S. Aal, Natasha Nazir

Pulsed laser ablation in liquid (PLAL) is a convenient, single step and green method for nanomaterial synthesis. Controlling nanoparticle size is crucial for various scientific and technological applications. In this paper, the effect of mixing ratio of composite liquid media and laser pulse energy on size distribution of silver nanocollides was exhibited. Mixing ratio of blend of high and low viscosity fluids—ethylene glycol and deionized water—was varied in the range from 0% to 100%. Additionally, the impact of laser pulse energy on AgNP size was explored while keeping the mixing ratio constant. Properties of the particles, including morphology, size, and plasmonic behavior, were examined using SEM, EDX, and optical absorption spectroscopy, and the underlying mechanisms are discussed. The colloids were of spherical shape and showed surface plasmon resonance around 400 nm. The size of the nanoparticle appeared to vary from 15 nm to 86 nm by increasing the concentration of ethylene glycol in the mixture. A similar effect was observed with the laser energy: the particle size increased from 24 nm to 75 nm as the laser energy was varied from 70 mJ to 150 mJ. The nanocolloids were also effective as antibacterial agents against Gram-positive and Gram-negative bacteria: the small-sized particles showed higher toxicity compared to the large particles. In addition to the laser energy, variation in nanoparticle size distribution by the interplay of mixing ratio of the liquid media is an interesting aspect of the findings.

液体脉冲激光烧蚀法(PLAL)是一种便捷、单步、绿色的纳米材料合成方法。控制纳米粒子的尺寸对各种科学和技术应用至关重要。本文研究了复合液体介质的混合比和激光脉冲能量对纳米银环的粒度分布的影响。高粘度液体和低粘度液体(乙二醇和去离子水)的混合比在 0% 到 100% 的范围内变化。此外,在保持混合比不变的情况下,还探讨了激光脉冲能量对 AgNP 尺寸的影响。使用 SEM、EDX 和光学吸收光谱检查了颗粒的特性,包括形态、尺寸和等离子行为,并讨论了其基本机制。胶体呈球形,在 400 nm 附近显示出表面等离子体共振。随着混合物中乙二醇浓度的增加,纳米粒子的大小从 15 纳米到 86 纳米不等。在激光能量方面也观察到类似的效果:激光能量从 70 mJ 到 150 mJ 变化时,颗粒尺寸从 24 nm 增加到 75 nm。纳米胶体作为抗菌剂对革兰氏阳性和革兰氏阴性细菌也很有效:与大颗粒相比,小颗粒显示出更高的毒性。除激光能量外,液体介质的混合比对纳米粒子大小分布的影响也是研究结果的一个有趣方面。
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引用次数: 0
Design of Simultaneous Refractive Index Sensor Across Multi-Photonic Bandgaps Using Tamm Plasmon Modes 利用塔姆等离子体模式设计跨多光子带隙的同步折射率传感器
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-03 DOI: 10.1007/s11468-024-02454-7
Anup Kumar Sharma, Amod Kumar Srivastava, Partha Sona Maji, Samir Kumar

In this work, a refractive index sensor based on Tamm plasmons mode is proposed, capable of concurrent functionality across multiple photonic bandgaps. The proposed sensor structure consists of an analyte cavity sandwiched between a one-dimensional photonic crystal of SiO2/TiO2 and a thin metal film. Multiple photonic bandgaps are observed in multilayer structures composed of SiO2/TiO2 layers, each with a thickness of 150 nm. Tamm plasmon resonances have been demonstrated in various photonic bandgaps, enabling the detection of subtle changes in refractive index within the cavity region. Simulation studies utilizing the transfer matrix method (TMM) have been conducted to evaluate the performance of the proposed design. Several sensor metrics including sensitivity, full width at half-maximum, quality factor, and detection accuracy were assessed for evaluating sensor performance. The functioning principle of this optical sensor relies on altering the refractive index of the analyte, resulting in a shift in either the transmission or reflection spectrum. The study reveals that the resonance wavelength demonstrates a linear variation with the change in the analyte’s refractive index. The results demonstrate that the one-dimensional photonic crystal sensor based on multiple Tamm plasmons exhibits high quality factor and enhanced detection accuracy and is well-suited for detecting minute changes in analyte refractive index. Tamm resonance-based sensors, notable for their main advantage of prism-free coupling, offer a compelling alternative to other optical sensors like surface plasmon resonance-based sensors.

本研究提出了一种基于塔姆质子模式的折射率传感器,能够在多个光子带隙中同时发挥作用。所提出的传感器结构由夹在二氧化硅/二氧化钛一维光子晶体和金属薄膜之间的分析空腔组成。在由二氧化硅/二氧化钛层(每层厚度为 150 纳米)组成的多层结构中,可以观察到多重光子带隙。塔姆等离子体共振已在各种光子带隙中得到证实,从而能够检测到空腔区域内折射率的微妙变化。我们利用传递矩阵法(TMM)进行了仿真研究,以评估拟议设计的性能。为评估传感器性能,对灵敏度、半最大全宽、品质因数和检测精度等传感器指标进行了评估。这种光学传感器的工作原理依赖于改变被分析物的折射率,从而导致透射或反射光谱的移动。研究显示,共振波长与分析物折射率的变化呈线性变化。研究结果表明,基于多个塔姆等离子体的一维光子晶体传感器具有较高的品质因数和更高的检测精度,非常适合检测分析物折射率的微小变化。基于塔姆共振的传感器以其无棱镜耦合的主要优势而著称,为其他光学传感器(如基于表面等离子体共振的传感器)提供了令人信服的替代方案。
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引用次数: 0
Development of a Multi-Band High-Sensitivity Polarization-Independent Absorber: A Biosensor for Simultaneous Detection of Multiple Cancer Biomarkers 开发多波段高灵敏度偏振无关吸收器:同时检测多种癌症生物标记物的生物传感器
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-02 DOI: 10.1007/s11468-024-02451-w
Yousef Rafighirani, Javad Javidan, Hamid Heidarzadeh

Traditionally, biosensors are indeed designed to detect one specific analyte. However, recent advancements in biosensor technology have enabled the development of multiplexed biosensors capable of detecting multiple analytes simultaneously. This work proposes the detection of cervical cancer (HeLa cells), skin cancer (basal cells), and breast cancer (MDA-MB-231 cells) by analyzing the refractive index of these cells. This analysis is based on comparing the absorption spectra of healthy and cancerous cells. The proposed structure comprises three layers: a copper layer with a conductivity of 5.18 × /m, a silicon dioxide layer with a refractive index of 3.9 containing a cross-shaped hole with a depth of 3.5 µm, and a graphene layer. For the basal cell biosensor, the graphene layer is assigned a chemical potential of 0.7 eV; for the HeLa cell biosensor, it is 0.8 eV, and for the MDA-MB-231 cell biosensor, it is 0.9 eV. The absorption output extracted from CST software yields the highest sensitivity values. For basal cell detection, the highest sensitivity (7100) and a figure of merit (FOM) of 22 are achieved in mode B. For HeLa cell detection, a sensitivity of 5250 and FOM of 28 are attained in mode B. Finally, for MDA-MB-231 detection, a sensitivity of 5357 and FOM of 23 are achieved in mode B. This innovation is particularly beneficial in complex biological samples where the presence of multiple analytes may provide more comprehensive diagnostic information. The proposed multi-band high-sensitivity polarization-independent absorber serves as a notable example of this trend, demonstrating the potential for biosensors to evolve toward simultaneous detection of multianalyte targets, such as different types of cancer cells.

传统的生物传感器实际上是为检测一种特定的分析物而设计的。然而,生物传感器技术的最新进展使得能够同时检测多种分析物的多路复用生物传感器得以发展。本研究提出通过分析宫颈癌(HeLa 细胞)、皮肤癌(基底细胞)和乳腺癌(MDA-MB-231 细胞)细胞的折射率来检测这些癌症。这种分析基于健康细胞和癌细胞吸收光谱的比较。拟议的结构由三层组成:导电率为 5.18 × /m 的铜层、折射率为 3.9 且含有深度为 3.5 µm 的十字形孔的二氧化硅层以及石墨烯层。对于基底细胞生物传感器,石墨烯层的化学势为 0.7 eV;对于 HeLa 细胞生物传感器,化学势为 0.8 eV;对于 MDA-MB-231 细胞生物传感器,化学势为 0.9 eV。从 CST 软件提取的吸收输出产生了最高的灵敏度值。对于基底细胞检测,模式 B 的灵敏度最高(7100),优点系数(FOM)为 22。在检测 HeLa 细胞时,模式 B 的灵敏度为 5250,优点指数为 28。最后,对于 MDA-MB-231 的检测,模式 B 的灵敏度为 5357,FOM 为 23。这一创新尤其适用于复杂的生物样本,因为多种分析物的存在可以提供更全面的诊断信息。所提出的多波段高灵敏度偏振无关吸收器是这一趋势的一个显著例子,展示了生物传感器向同时检测多种分析目标(如不同类型的癌细胞)发展的潜力。
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引用次数: 0
An Investigation of Low-Loss Sodium Plasmon Waveguides Based on FEM 基于有限元的低损耗钠等离子体波导研究
IF 3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-08-01 DOI: 10.1007/s11468-024-02457-4
Xiaodi Yang, Shuaiqi Ma, Da Teng

A sodium-based hybrid plasmonic waveguide consists of the Na film and wedge-shape Si ridge waveguide is designed. The overall performance of the waveguide and its application as a nano-laser are studied by using the finite element method (FEM) with emphasis on effective index, propagation length, normalized mode area, figure of merit, confinement factor, gain threshold, and Purcell factor. The results point out that the designed waveguide exhibits the strong field confinement ability as well as high figure of merit. Particularly, a large Purcell factor of 536 and an ultra-low gain threshold of 0.066 μm−1 could be concurrently obtained, which is far smaller than that of conventional Ag-based plasmonic waveguides. The proposed waveguide could potentially advance the utilization of sodium-based plasmonic waveguides in the field of nano-laser, resonator, modulator, and other nanophotonic devices.

设计了一种钠基混合质子波导,由 Na 薄膜和楔形硅脊波导组成。利用有限元法(FEM)研究了波导的整体性能及其作为纳米激光器的应用,重点研究了有效指数、传播长度、归一化模式面积、优点系数、场约束因子、增益阈值和珀塞尔因子。结果表明,所设计的波导具有很强的场约束能力和很高的优越性。特别是同时获得了 536 的高珀赛尔因子和 0.066 μm-1 的超低增益阈值,远小于传统的银基等离子体波导。该波导有望推动钠基等离子波导在纳米激光、谐振器、调制器和其他纳米光子器件领域的应用。
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