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Exploring the Impact of Sensor Location On Seismocardiography-Derived Cardiac Time Intervals 探讨传感器位置对心电地震得出的心脏时间间隔的影响
Pub Date : 2023-08-17 DOI: 10.1115/1.4063203
Aysha Mann, Peshala Thibbotuwawa Gamage, B. Kakavand, Amirtahà Taebi
Cardiac time intervals (CTIs) are important parameters for evaluating cardiac function and can be measured noninvasively through electrocardiography (ECG) and seismocardiography (SCG). SCG signals exhibit distinct spectrotemporal characteristics when acquired from various locations on the chest. Thus, this study aimed to explore how SCG measurement location affects the estimation of SCG-based CTIs. ECG and SCG signals were acquired from 14 healthy adults, with three accelerometers placed on the top, middle, and bottom of the sternum. A custom-built algorithm was developed to estimate heart rates (HRs) from ECG (HRECG) and SCG (HRSCG) signals. Moreover, SCG fiducial points and CTIs, including aortic valve opening and closure, R-R interval, preejection period, left ventricular ejection time, and electromechanical systole, were estimated from the SCG signals at different sternal locations. The average and correlation coefficient (R2) of the CTIs and HRs derived from all three locations were compared, along with the analysis of mean differences for the CTIs and their corresponding sensor locations. The results indicated strong correlations between HRECG and HRSCG, with average R2 values of 0.9930, 0.9968, and 0.9790 for the top, middle, and bottom sternal locations, respectively. Additionally, the study demonstrated that SCG-based CTIs varied depending on the SCG measurement locations. In conclusion, these findings underscore the importance of establishing consistent protocols for reporting CTIs based on SCG. Furthermore, they call for further investigation to compare estimated CTIs with gold-standard methods like echocardiography to identify the best SCG measurement location for accurate CTI estimations.
心电时间间隔(CTIs)是评价心功能的重要参数,可通过心电图(ECG)和地震心动图(SCG)无创测量。SCG信号在胸部不同位置采集时表现出明显的光谱时间特征。因此,本研究旨在探讨SCG测量位置如何影响基于SCG的cti的估计。从14名健康成人获得心电图和SCG信号,在胸骨的顶部、中部和底部放置三个加速度计。开发了一种定制算法,从ECG (HRECG)和SCG (HRSCG)信号中估计心率(hr)。根据不同胸骨位置的SCG信号估计主动脉瓣开闭、R-R间期、射血前期、左室射血时间、机电收缩期等SCG基准点和CTIs。比较了三个位置的cti和hr的平均值和相关系数(R2),并分析了cti及其相应传感器位置的平均差异。结果表明,HRECG与HRSCG具有较强的相关性,胸骨上、中、下三个部位的平均R2分别为0.9930、0.9968、0.9790。此外,该研究还表明,基于SCG的cti随SCG测量位置的不同而变化。总之,这些发现强调了基于SCG建立一致的cti报告方案的重要性。此外,他们呼吁进行进一步的研究,将估计的CTI与超声心动图等金标准方法进行比较,以确定准确估计CTI的最佳SCG测量位置。
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引用次数: 1
Steering Control Improvement of Active Surgical Needle using Mosquito Proboscis-Inspired Cannula 蚊子鼻式插管对手术主动针转向控制的改进
Pub Date : 2023-08-17 DOI: 10.1115/1.4063200
Sharada Acharya, Doyoung Kim, P. Hutapea
Active needles obtain more significant tip deflection and improved accuracy over passive needles for percutaneous procedures. However, their ability to navigate through tissues to reach targets depends upon the actuation mechanism, the tip shape, and the surface geometry of the shaft. In this study, we investigate the benefits of changing the surface geometry of the active needle shaft in a) needle tip deflection and b) trajectory tracking during tissue insertion. The modifications in passive needle surface geometry have been proven to reduce friction force, tissue displacement, and tissue damage. This study incorporates the effect of modifying the regular smooth cannula with a mosquito proboscis-inspired design in the active needles. The changes in insertion force, tip deflection, and trajectory tracking control during insertion into a prostate-mimicking phantom are measured. Results show that insertion force is reduced by up to 10.67% in passive bevel-tip needles. In active needles, tip deflection increased by 12.91% at 150mm when the cannula is modified. The bioinspired cannula improved trajectory tracking error in the active needle by 39.00% while utilizing up to 17.65% lower control duty cycle. Improving tip deflection and tracking control would lead to better patient outcomes and reduced risk of complications during percutaneous procedures.
在经皮手术中,主动针比被动针获得更显著的针尖偏转和更高的准确性。然而,它们穿越组织到达目标的能力取决于驱动机制、尖端形状和轴的表面几何形状。在这项研究中,我们研究了在a)针尖偏转和b)组织插入过程中轨迹跟踪中改变活动针轴表面几何形状的好处。被动针表面几何形状的改变已被证明可以减少摩擦力、组织位移和组织损伤。这项研究结合了在活性针头中使用蚊子喙设计修改常规光滑套管的效果。在插入过程中,测量了插入力、尖端偏转和轨迹跟踪控制的变化。结果表明,被动斜尖针的插入力降低了10.67%。在活性针中,改良后的导管在150mm处的尖端偏转增加了12.91%。仿生套管将主动针的轨迹跟踪误差提高了39.00%,同时控制占空比降低了17.65%。改善针尖偏转和跟踪控制将导致更好的患者预后,并减少经皮手术并发症的风险。
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引用次数: 0
Computational Modeling of an Aortic Medial Ring: Effect of Residual Stresses On a Mechanical Behavior of the Aortic Ring 主动脉内侧环的计算模型:残余应力对主动脉环力学行为的影响
Pub Date : 2023-08-09 DOI: 10.1115/1.4063140
A. Tamura, K. Matsumoto, Junichi Hongu
The aorta is the largest artery in an animal body and is an important organ in the pulsatile flow regulation from the left ventricle. The mechanical and structural characteristics of the aortic media, which are primarily composed of smooth muscle cell layers (SMLs) and elastic laminae (ELs), have profound effects on the physiology and pathophysiology of the aorta. However, many aspects of the aortic tissue remain unknown due to the inherent layered wall structure and the regionally varying residual stresses. This study aimed to computationally represent EL buckling in the aortic medial ring at the unloaded state and reproduce the transmural variation in residual stresses and EL waviness across the vascular wall. A multiobjective optimization technique was applied to a series of simulations with the "unit" structure to obtain an idealized stress distribution throughout the aortic wall thickness. Hence, an appropriate boundary condition given to an initial reference configuration of the aortic ring was successfully identified. As a result, the average "idealized" residual stresses of SML and EL were on the order of 20 and -80 kPa, respectively, while EL waviness was ~1.01 in the unloaded state. Further, it was verified that the ring model with a radial cut will open spontaneously when the inner and outer layers of the medial wall are subjected to relative compressive and tensile residual stresses, respectively, in the unloaded state.
主动脉是动物体内最大的动脉,是调节左心室脉动血流的重要器官。主动脉介质主要由平滑肌细胞层(SMLs)和弹性层(ELs)组成,其力学和结构特性对主动脉的生理和病理生理有着深远的影响。然而,由于固有的层状壁结构和区域变化的残余应力,主动脉组织的许多方面仍然未知。本研究旨在通过计算再现主动脉内侧环在无载荷状态下的EL屈曲,再现残余应力和EL波形在血管壁上的跨壁变化。采用多目标优化技术对“单元”结构进行了一系列模拟,得到了理想的主动脉壁厚度应力分布。因此,一个适当的边界条件给予一个初始参考配置的主动脉环被成功地确定。结果表明,SML和EL的平均“理想”残余应力分别为20和-80 kPa,而EL在卸载状态下的波纹度为~1.01。进一步验证了具有径向切口的环形模型在卸载状态下,内侧壁内层和外层分别受到相对残余压应力和拉应力时,会自发打开。
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引用次数: 0
An Affordable Telerobotic System Architecture for Grasp Training and Object Grasping for Human-machine Interaction 一种可负担的人机交互抓取训练和物体抓取遥机器人系统架构
Pub Date : 2023-08-01 DOI: 10.1115/1.4063072
Sudip Hazra, Abdul Hafiz Abdul Rahaman, P. Shiakolas
Due to mobility impairment, a person might rely on wheelchairs, canes, and crutches for assistance but could face challenges when performing tasks such as grasping and manipulating objects due to limitations in reach and capability. To overcome these challenges, a multi-degree-of-freedom robotic arm with an anthropomorphic robotic hand (ARH) could be used. In this research, we propose an architecture and then implement it towards the development of an assistive system to assist a person with object grasping. The architecture interlinks three functional modules to provide three operation modes to calibrate the system, train a user on how to execute a grasp, synthesize grasps, and execute a grasp. The developed system consists of a user input and feedback glove capable of capturing user inputs and providing grasp-related vibrotactile feedback, a CoppeliaSim-based virtual environment emulating the motions of the ARH, and an underactuated ARH capable of executing grasps while sensing grasp contact locations. The operation of the developed system is evaluated to determine the ability of a person to operate it and perform a grasp using two control methods; using a synthesized grasp or under real-time continuous control. The successful evaluation validates the architecture and the developed system to provide the ability to perform a grasp. The results of the evaluation provide confidence in expanding the system capabilities and use it to develop a database of grasp trajectories of objects with different geometries.
由于行动障碍,一个人可能依赖轮椅、手杖和拐杖来帮助,但在执行诸如抓握和操纵物体等任务时,由于接触和能力的限制,可能会面临挑战。为了克服这些挑战,可以使用具有拟人化机械手(ARH)的多自由度机械臂。在这项研究中,我们提出了一个架构,然后将其实现到辅助系统的开发中,以帮助人们抓取物体。该体系结构将三个功能模块连接起来,提供三种操作模式来校准系统,训练用户如何执行抓握、综合抓握和执行抓握。开发的系统包括一个用户输入和反馈手套,能够捕获用户输入并提供与抓取相关的振动触觉反馈,一个基于coppeliasim的虚拟环境模拟ARH的运动,以及一个能够在感知抓取接触位置时执行抓取的欠驱动ARH。对所开发的系统的操作进行评估,以确定一个人操作它的能力,并使用两种控制方法执行抓握;采用综合抓取或实时连续控制。成功的评估验证了体系结构和开发的系统,以提供执行把握的能力。评估结果为扩展系统功能提供了信心,并将其用于开发具有不同几何形状的物体抓取轨迹数据库。
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引用次数: 0
Verification Process for Finite Element Modeling Techniques Used in Biological Hard Tissue 生物硬组织有限元建模技术的验证过程
Pub Date : 2023-08-01 DOI: 10.1115/1.4063302
Molly Townsend, Matthew Mills, N. Sarigul-Klijn
An approach is presented for calculation verification of geometry-based and voxel-based finite element modeling techniques used for biological hard tissue. The purpose of this study is to offer a controlled comparison of geometry- and voxel-based finite element modeling in terms of the convergence (i.e., discretization based on mesh size and/or element order), accuracy, and computational speed in modeling biological hard tissues. All of the geometry-based numerical test models have hp-converged at an acceptable mesh seed length of 0.6mm, while not all voxel-based models exhibited convergence and no voxel models p-converged. Converged geometry-based meshes were found to offer accurate solutions of the deformed model shape and equivalent vertebral stiffness, while voxel-based models were 6.35%±0.84% less stiff (p<0.0001) and deformed 6.79%±0.96% more (p<0.0001). Based on the controlled verification study results, the voxel-based models must be confirmed with local values and validation of quantities of interest to ensure accurate finite element model predictions.
提出了一种用于生物硬组织的基于几何和基于体素的有限元建模技术的计算验证方法。本研究的目的是在生物硬组织建模的收敛性(即基于网格大小和/或单元顺序的离散化)、准确性和计算速度方面,对基于几何和基于体素的有限元建模进行控制比较。所有基于几何的数值测试模型都在可接受的0.6mm网格种子长度处具有hp收敛性,而并非所有基于体素的模型都具有收敛性,并且没有体素模型具有p收敛性。基于收敛几何的网格可以准确地解出变形模型的形状和等效椎体刚度,而基于体素的模型刚度降低了6.35%±0.84% (p<0.0001),变形增加了6.79%±0.96% (p<0.0001)。基于控制验证研究结果,必须对基于体素的模型进行局部值和感兴趣量的验证,以确保准确的有限元模型预测。
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引用次数: 0
Development of a Multilayer Iliac Crest Numerical Model for Simulating Honeybee Stinger-Inspired Hollow Needle Insertion 基于多层髂骨数值模型的蜜蜂螫刺式空心针插入模拟
Pub Date : 2023-07-27 DOI: 10.1115/1.4063054
R. Nadda, R. Repaka, A. Sahani
Minimally invasive biopsy needles are frequently inserted into the desired body regions while performing the bone marrow biopsy (BMB) procedure. The key problem with needle insertion in tissues is that the insertion force damages the tissue and deviates the needle path, leading the needle to miss the desired target and reducing biopsy sample integrity. To address these shortcomings, the present work developed a unique bioinspired barbed biopsy needle design that reduces insertion/extraction forces and needle deflection. This study established several design parameters, including barb geometry and shape (viz., the height of barb, barbed front angle, barbed back angle, and length of portion containing barbs), and examined the impact of these factors on insertion/extraction force and deflection. A Lagrangian surface-based non-linear finite element (FE) approach has been used to numerically simulate the BMB procedure on a three-dimensional (3D) multilayered heterogeneous model of the human iliac crest. The proposed honeybee stinger-inspired needle design has been found to reduce both insertion and extraction forces because of the decreased frictional surface of the biopsy needle.
在进行骨髓活检(BMB)过程中,微创活检针经常插入所需的身体区域。在组织中插入针头的关键问题是,插入力会破坏组织并使针头路径偏离,导致针头偏离预期目标并降低活检样本的完整性。为了解决这些缺点,本研究开发了一种独特的生物启发刺活检针设计,可以减少插入/拔出力和针挠度。本研究建立了几个设计参数,包括倒刺的几何形状(即倒刺高度、倒刺前角、倒刺后角和含倒刺部分的长度),并研究了这些因素对插拔力和挠度的影响。采用基于拉格朗日曲面的非线性有限元(FE)方法,在三维(3D)多层非均匀人体髂骨模型上对BMB过程进行数值模拟。研究发现,由于活检针的摩擦表面减少,因此提出的受蜜蜂螫针启发的针头设计可以减少插入和拔出力。
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引用次数: 0
Finite Element Analysis of a Temporomandibular Joint Implant 颞下颌关节植入物的有限元分析
Pub Date : 2023-07-01 DOI: 10.1115/1.4062893
Vivek Kumar Mall, P. Wahi, Niraj Sinha
Temporomandibular joint (TMJ) is a synovial joint that allows for movement of the jaw in relation to the skull. TMJs are located on both sides of the face, one on either side. It aids in performing of activities such as eating. TMJ disorder may sometime require an implant to replace this joint. Excessive stress on certain screws and implants may adversely affect the TMJ implant and may lead to breakage and requirement of replacement. Therefore, to predict stresses in the implant, finite element analysis (FEA) has been used in this study. We have simulated a human bite by applying force to the teeth and allowing the condyle to rotate and translate over the fossa with the restrictions on the rigid body motions coming from flexible muscles which are modelled as axial connector elements. This method is novel because it eliminates the need to collect data on muscle forces in order to simulate the TMJ as was done conventionally. Each individual mandibular tooth can be loaded in this simulation. Because of the reduced amount of restriction placed on the TMJ implant, it is possible to better understand the true stresses that will be generated under the routine movement of the jaw.
颞下颌关节(TMJ)是一个滑膜关节,允许下颌相对于颅骨的运动。颞下颌关节位于面部两侧,两侧各一个。它有助于进食等活动的进行。颞下颌关节紊乱有时需要植入物来代替这个关节。某些螺钉和植入物的过度应力可能对TMJ植入物产生不利影响,并可能导致断裂和需要更换。因此,为了预测种植体的应力,本研究使用了有限元分析(FEA)。我们通过对牙齿施加力,并允许髁突在窝上旋转和平移来模拟人类的咬伤,同时限制来自柔性肌肉的刚体运动,这些肌肉被建模为轴向连接器元件。这种方法是新颖的,因为它消除了为了模拟TMJ而收集肌肉力量数据的需要。每个单独的下颌牙齿都可以在这个模拟中加载。由于减少了对TMJ植入物的限制,因此可以更好地了解下颌常规运动下产生的真实应力。
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引用次数: 0
Behavior of a Confluent Layer of Myoblasts Under Shear Flow 剪切流作用下成肌细胞融合层的行为
Pub Date : 2023-06-23 DOI: 10.1115/1.4062705
S. Hashimoto, Haruki Kinoshiro, Yuta Nagasawa
To investigate the effect of shear stress direction on the direction of cell activity in a confluent layer, the migration and deformation of cells oriented parallel or perpendicular to the direction of the shear flow field were optically tracked in vitro. A Couette-type shear flow between parallel walls was formed between the lower stationary culture dish and the upper rotating disk. Shear stress (<2 Pa) was set by adjusting the rotational speed of the upper disk. Myoblasts (C2C12: mouse myoblast cell line) were cultured in an incubator equipped with an inverted phase-contrast microscope under continuous shear flow for 7 days until confluency. Deformation and migration of each cell were tracked in time-lapse images. Analysis of these images showed that cells deform and migrate along their major axis even at confluency (whether the major axis of the cell is parallel or perpendicular to the shear stress field). As a result, the orientation of the major axis of the cell remains parallel or perpendicular to the shear stress field. This observation may be used to improve the development of engineered muscle tissue.
为了研究剪切应力方向对合流层中细胞活动方向的影响,在体外光学跟踪了平行或垂直于剪切流场方向的细胞的迁移和变形。下部固定培养皿与上部旋转培养皿之间形成平行壁面间的库特型剪切流。剪切应力(<2 Pa)通过调节上盘转速来设定。将成肌细胞(C2C12:小鼠成肌细胞系)在配备倒置相差显微镜的培养箱中连续剪切流培养7天至细胞融合。在延时图像中跟踪每个细胞的变形和迁移。对这些图像的分析表明,即使在合流状态下(无论细胞的长轴与剪切应力场平行还是垂直),细胞也会沿着它们的长轴变形和迁移。因此,细胞的长轴方向保持平行或垂直于剪切应力场。这一观察结果可用于改善工程肌肉组织的发育。
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引用次数: 0
An Algorithm for Rendering Force Fields at Many and Close Control Points Using Acoustic Holography for Ultrasound Therapy 超声治疗中声全息多控制点力场绘制算法研究
Pub Date : 2023-06-23 DOI: 10.1115/1.4062684
Tomoya Shinato, T. Shiraishi
Ultrasound therapy is advantageous because it is a noninvasive treatment for the body. Low-intensity pulsed ultrasound can aid fracture healing. We focus on phased array transducers (PATs) to render force fields and realize the improvement in medical equipment to enhance this therapy. This can both render an arbitrary acoustic field and quickly change it by controlling the output and phase of each transducer. There are some algorithms for controlling PATs; however, the effectiveness of these algorithms is limited at sparse control points. We propose a novel algorithm to control PATs at many and close control points in this research. We compare the proposed algorithm with previous ones and assess the avoidance of negative effects outside the target area. The findings show that the proposed algorithm achieves both excellent reconstruction performance and low computational cost, and it can render an acoustic field sufficient to prevent negative effects on the body.
超声治疗的优势在于它对身体是一种非侵入性治疗。低强度脉冲超声有助于骨折愈合。我们专注于相控阵换能器(PATs)来呈现力场,并实现医疗设备的改进以增强这种治疗。这既可以渲染任意声场,又可以通过控制每个换能器的输出和相位来快速改变它。有一些控制pat的算法;然而,这些算法的有效性在稀疏控制点处受到限制。在本研究中,我们提出了一种新的算法来控制多控制点和近控制点的pat。我们将所提出的算法与先前的算法进行比较,并评估避免目标区域外的负面影响。研究结果表明,该算法具有良好的重建性能和较低的计算成本,并且可以使声场足以防止对身体的负面影响。
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引用次数: 0
Special Section on Recent Developments of Orthopedic and Dental Implants 骨科及牙科种植体最新发展专题
Pub Date : 2023-06-14 DOI: 10.1115/1.4062693
O. Mukdadi, Sandipan Roy, A. Merdji
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引用次数: 0
期刊
Journal of engineering and science in medical diagnostics and therapy
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