Pub Date : 2020-11-04DOI: 10.11648/J.IJIDT.20200504.14
I. Basse, P. Faye, A. Sow, Marie Acakpo, N. Seck, Lamine Thiam, N. Ndiaye, Dina Obambi, D. Boiro, A. A. Ndongo, N. Guèye, O. Ndiaye
Introduction: Despite much progress, purulent childhood meningitis (PCM) remains a public health problem. The objective of this work was to determine the epidemiological, clinical, therapeutic and evolutionary profile of purulent meningitis in children. Methods: Based on retrospective work carried out over a 4-year period (01 January 2014 to 31 December 2017), we studied the epidemiological, clinical, therapeutic and evolutionary aspects of cases of purulent meningitis hospitalized in the pediatric ward of the Children's Hospital of Diamniadio. Included were all children from 29 days to 15 years of age in whom the diagnosis of purulent meningitis was confirmed by the laboratory. Results: The hospital frequency was 1.9%. The mean age of the patients was 41.0 months. Among the affected children, 68.6% were fully vaccinated. The main germ was Neisseria meningitidis W135 (58.8%). Third generation cephalosporins were the antibiotics of choice (97.1%). No resistance was found to them. The cure rate with sequelae was 5.7%. Streptococcus pneumoniae was the germ responsible for 50% of the objective sequelae. The mortality rate was 7.1%. Conclusion: Neisseria meningitidis W135 is the main germ of purulent meningitis in our study. It is not included in the national routine immunization. It is imperative to adapt vaccination to the epidemiological fluctuation of pathogens in our regions.
{"title":"Purulent Meningitis in Children: A Retrospective Study of 70 Cases in Senegal","authors":"I. Basse, P. Faye, A. Sow, Marie Acakpo, N. Seck, Lamine Thiam, N. Ndiaye, Dina Obambi, D. Boiro, A. A. Ndongo, N. Guèye, O. Ndiaye","doi":"10.11648/J.IJIDT.20200504.14","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200504.14","url":null,"abstract":"Introduction: Despite much progress, purulent childhood meningitis (PCM) remains a public health problem. The objective of this work was to determine the epidemiological, clinical, therapeutic and evolutionary profile of purulent meningitis in children. Methods: Based on retrospective work carried out over a 4-year period (01 January 2014 to 31 December 2017), we studied the epidemiological, clinical, therapeutic and evolutionary aspects of cases of purulent meningitis hospitalized in the pediatric ward of the Children's Hospital of Diamniadio. Included were all children from 29 days to 15 years of age in whom the diagnosis of purulent meningitis was confirmed by the laboratory. Results: The hospital frequency was 1.9%. The mean age of the patients was 41.0 months. Among the affected children, 68.6% were fully vaccinated. The main germ was Neisseria meningitidis W135 (58.8%). Third generation cephalosporins were the antibiotics of choice (97.1%). No resistance was found to them. The cure rate with sequelae was 5.7%. Streptococcus pneumoniae was the germ responsible for 50% of the objective sequelae. The mortality rate was 7.1%. Conclusion: Neisseria meningitidis W135 is the main germ of purulent meningitis in our study. It is not included in the national routine immunization. It is imperative to adapt vaccination to the epidemiological fluctuation of pathogens in our regions.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"127"},"PeriodicalIF":0.0,"publicationDate":"2020-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44498868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-17DOI: 10.11648/J.IJIDT.20200504.13
S. Badreddine, M. Zammo, A. Elhosiny, Mohanna Walid Alhomsy, Y. Aldabbagh, Abdullah Sameer Mansouri, Sara Hesham Taha, Reem Yahya ALQuraa, A. A. A. Nahdi, A. Eissa, H. Faruqui, N. Ahmed, Ahmad Alzahrani, N. Bahabri
Background: Since the first case of SARS-CoV 2 has been reported from Wuhan China back in December 2019, the virus has spread all over the world and has so far infected more than 35 million humans and led to more than one million deaths woldwide. We describe in this paper the clinical characteristics and outcome of PCR confirmed Covid 19 patients that were admitted to a tertiary care hospital in Saudi Arabia. Methods: Retrospective review of patients that had positive PCR on nasopharyngeal swab for SARS Cov2 and that were admitted and discharged from a tertiary care hospital in the city of Jeddah, Saudi Arabia between March and July 2020. Epidemiological, demographic, and clinical data were collected. The clinical course of patients was reviewed. Risk factors for involvement of lower respiratory tract (Pneumonia), for need for ICU and for death were analyzed. Results: The records of total of 395 patients were reviewed. 15% of Covid 19 patients in our population were completely asymptomatic, one quarter of which had abnormalities on chest imaging. Among the patients with one or more Covid 19 symptoms, 75% had lower respiratory tract involvement and one quarter had normal chest imaging. One third of all patients developed leukopenia and around 2 thirds had lymphocytopenia. Thrombocytopenia was not common (occurred in 15%), 29% of our patients had CRP>10 and 25.1% had elevated ALT (not exceeding 5 times upper normal). Nine percent of our patients needed ICU admission, 3.8% needed mechanical ventilation. 9 patients (2.3%) in our population died. Advancing age, increasing BMI, and smoking history were significantly associated with increased mortality. Developing abnormalities on chest imaging (Pneumonia) was significantly associated with increasing BMI, advancing age, not receiving BCG vaccination at birth, history of smoking and presence of co-morbidities (p value less 0.05 with all these variables). Blood group and presence of co-morbidities was significantly associated with need for ICU care but not with mortality. In our population neither ethnicity, nor gender, had significant association with hospital course or outcome, and no one younger than 45 years and no one with BMI less than 24 died. Conclusion: Advancing age, increasing BMI and history of smoking were found to be significant risk factors for mortality in our population. History of Bacille calmette Guerin (BCG) vaccination was significantly associated with less involvement of lower respiratory tract but had no significant association with final outcome. Asymptomatic Covid 19 is more of a silent active infection rather than a silent inactive carrier state.
{"title":"Clinical Course and Outcome of 395 Covid 19 Patients Admitted to One Hospital in Jeddah- Saudi Arabia","authors":"S. Badreddine, M. Zammo, A. Elhosiny, Mohanna Walid Alhomsy, Y. Aldabbagh, Abdullah Sameer Mansouri, Sara Hesham Taha, Reem Yahya ALQuraa, A. A. A. Nahdi, A. Eissa, H. Faruqui, N. Ahmed, Ahmad Alzahrani, N. Bahabri","doi":"10.11648/J.IJIDT.20200504.13","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200504.13","url":null,"abstract":"Background: Since the first case of SARS-CoV 2 has been reported from Wuhan China back in December 2019, the virus has spread all over the world and has so far infected more than 35 million humans and led to more than one million deaths woldwide. We describe in this paper the clinical characteristics and outcome of PCR confirmed Covid 19 patients that were admitted to a tertiary care hospital in Saudi Arabia. Methods: Retrospective review of patients that had positive PCR on nasopharyngeal swab for SARS Cov2 and that were admitted and discharged from a tertiary care hospital in the city of Jeddah, Saudi Arabia between March and July 2020. Epidemiological, demographic, and clinical data were collected. The clinical course of patients was reviewed. Risk factors for involvement of lower respiratory tract (Pneumonia), for need for ICU and for death were analyzed. Results: The records of total of 395 patients were reviewed. 15% of Covid 19 patients in our population were completely asymptomatic, one quarter of which had abnormalities on chest imaging. Among the patients with one or more Covid 19 symptoms, 75% had lower respiratory tract involvement and one quarter had normal chest imaging. One third of all patients developed leukopenia and around 2 thirds had lymphocytopenia. Thrombocytopenia was not common (occurred in 15%), 29% of our patients had CRP>10 and 25.1% had elevated ALT (not exceeding 5 times upper normal). Nine percent of our patients needed ICU admission, 3.8% needed mechanical ventilation. 9 patients (2.3%) in our population died. Advancing age, increasing BMI, and smoking history were significantly associated with increased mortality. Developing abnormalities on chest imaging (Pneumonia) was significantly associated with increasing BMI, advancing age, not receiving BCG vaccination at birth, history of smoking and presence of co-morbidities (p value less 0.05 with all these variables). Blood group and presence of co-morbidities was significantly associated with need for ICU care but not with mortality. In our population neither ethnicity, nor gender, had significant association with hospital course or outcome, and no one younger than 45 years and no one with BMI less than 24 died. Conclusion: Advancing age, increasing BMI and history of smoking were found to be significant risk factors for mortality in our population. History of Bacille calmette Guerin (BCG) vaccination was significantly associated with less involvement of lower respiratory tract but had no significant association with final outcome. Asymptomatic Covid 19 is more of a silent active infection rather than a silent inactive carrier state.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"118"},"PeriodicalIF":0.0,"publicationDate":"2020-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48588616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-13DOI: 10.11648/J.IJIDT.20200504.12
J. Coursen, P. Roth, C. Schrank, J. Schrank
Several studies have established outpatient parenteral antibiotic therapy (OPAT) as an alternative to prolonged inpatient stays to reduce healthcare expenditure, decrease hospital admission times, and increase patient satisfaction. However, studies have also shown significant adverse events occurring while receiving treatment outpatient. We collected retrospective data through electronic medical record review on all patients discharged on IV antibiotics whose OPAT was managed by the infectious disease specialists at Greenville Health System between 1/1/17 and 6/30/17. There were a total of 336 individual patients discharged on OPAT during the 6 month period. Bacteremia (25.4%), osteomyelitis (14.9%), and diabetic foot infections (12.8%) were the most common indications for OPAT with methicillin-sensitive staphylococcus aureus (MSSA) being the most common organism targeted (22.5%). 11% of patients had a medication change during their treatment course. The most common reasons were nausea/malaise (26%) and acute kidney injury (26%). Our hospital re-admission rate was 8.7%. Statistical analysis of the data indicated that home infusion was significantly more likely to result in re-admission compared to the infusion center (p=0.02). Also receiving antibiotics for osteomyelitis was more likely to result in re-admission compared to other diagnoses (p=0.048). Our data indicates that self-administration of antibiotics at home results in higher re-admission rates compared to administration at infusion centers. Factors that may contribute to this difference such as compliance, co-morbidities, or frequency of nurse assessments warrant further exploration to optimize the safety of OPAT, especially in rural South Carolina.
{"title":"The Outpatient Parenteral Antimicrobial Therapy (OPAT) Experience in a Referral Hospital in South Carolina","authors":"J. Coursen, P. Roth, C. Schrank, J. Schrank","doi":"10.11648/J.IJIDT.20200504.12","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200504.12","url":null,"abstract":"Several studies have established outpatient parenteral antibiotic therapy (OPAT) as an alternative to prolonged inpatient stays to reduce healthcare expenditure, decrease hospital admission times, and increase patient satisfaction. However, studies have also shown significant adverse events occurring while receiving treatment outpatient. We collected retrospective data through electronic medical record review on all patients discharged on IV antibiotics whose OPAT was managed by the infectious disease specialists at Greenville Health System between 1/1/17 and 6/30/17. There were a total of 336 individual patients discharged on OPAT during the 6 month period. Bacteremia (25.4%), osteomyelitis (14.9%), and diabetic foot infections (12.8%) were the most common indications for OPAT with methicillin-sensitive staphylococcus aureus (MSSA) being the most common organism targeted (22.5%). 11% of patients had a medication change during their treatment course. The most common reasons were nausea/malaise (26%) and acute kidney injury (26%). Our hospital re-admission rate was 8.7%. Statistical analysis of the data indicated that home infusion was significantly more likely to result in re-admission compared to the infusion center (p=0.02). Also receiving antibiotics for osteomyelitis was more likely to result in re-admission compared to other diagnoses (p=0.048). Our data indicates that self-administration of antibiotics at home results in higher re-admission rates compared to administration at infusion centers. Factors that may contribute to this difference such as compliance, co-morbidities, or frequency of nurse assessments warrant further exploration to optimize the safety of OPAT, especially in rural South Carolina.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"112"},"PeriodicalIF":0.0,"publicationDate":"2020-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49481483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-07DOI: 10.11648/J.IJIDT.20200504.11
Ijezie Ntomchukwu Simon, M. Malau, M. David, Njab Jean Emile
The study on the performance of four rapid diagnostic test (RDT) kits (Global, LabAcon, SD Bioline and CareStart kits) in the diagnosis of Plasmodium falciparum was carried in North Central Nigeria for a period of twelve months to evaluate the performance of the kits using samples of symptomatic patients attending clinic. The performance of the kits was compared with that of microscopy as standard. Result of the sensitivity of the four RDT kits revealed that Global, LabAcon, SD Bioline and CareStart recorded 86.50%, 84.90%, 86.50% and 83.70% respectively while their level of specificity was 95.40%, 95.30%, 95.80% and 96.00% respectively. The four kits recorded no significant difference in sensitivity and specificity (p>0.005). SD Bioline, however, demonstrated the highest accuracy of 92.90% while LabAcon had the lowest accuracy (92.10%). The positive predictive values and negative predictive values of the four kits were; Global (87.80% and 94.10%), SD Bioline (87.80% and 94.30%), LabAcon (86.20% and 94.10%) and CareStart (85.00% and 94.60%). There was no significant difference in either the accuracy, positive predictive value and negative predictive value of the four kits (p >0.005). The overall performance of the four kits was also insignificantly different (p>0.005). The performance of the four kits was statistically different compared with microscopy test (p<0.005), so the RDT kits cannot replace microscopy, being the gold standard but can, however, be used for malaria diagnoses for ease of analysis.
{"title":"Performance of Four Malaria Rapid Diagnostic Tests (RDTs) in the Diagnosis of Malaria in North Central Nigeria","authors":"Ijezie Ntomchukwu Simon, M. Malau, M. David, Njab Jean Emile","doi":"10.11648/J.IJIDT.20200504.11","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200504.11","url":null,"abstract":"The study on the performance of four rapid diagnostic test (RDT) kits (Global, LabAcon, SD Bioline and CareStart kits) in the diagnosis of Plasmodium falciparum was carried in North Central Nigeria for a period of twelve months to evaluate the performance of the kits using samples of symptomatic patients attending clinic. The performance of the kits was compared with that of microscopy as standard. Result of the sensitivity of the four RDT kits revealed that Global, LabAcon, SD Bioline and CareStart recorded 86.50%, 84.90%, 86.50% and 83.70% respectively while their level of specificity was 95.40%, 95.30%, 95.80% and 96.00% respectively. The four kits recorded no significant difference in sensitivity and specificity (p>0.005). SD Bioline, however, demonstrated the highest accuracy of 92.90% while LabAcon had the lowest accuracy (92.10%). The positive predictive values and negative predictive values of the four kits were; Global (87.80% and 94.10%), SD Bioline (87.80% and 94.30%), LabAcon (86.20% and 94.10%) and CareStart (85.00% and 94.60%). There was no significant difference in either the accuracy, positive predictive value and negative predictive value of the four kits (p >0.005). The overall performance of the four kits was also insignificantly different (p>0.005). The performance of the four kits was statistically different compared with microscopy test (p<0.005), so the RDT kits cannot replace microscopy, being the gold standard but can, however, be used for malaria diagnoses for ease of analysis.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"106"},"PeriodicalIF":0.0,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41899210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-17DOI: 10.11648/J.IJIDT.20200503.21
M. I. Shago, Markus Kirwe Jiyil, Nazifi Alhaji Sani, G. Suleiman
Malaria remains a public health problem in over 90 countries worldwide, especially in Africa where it is the cause of morbidity and mortality. The aim of the study is to compare the sensitivity of two rapid diagnostic test kits in the diagnosis of malaria among patients attending Yobe State Specialist Hospital Damaturu. Patients were screened for malaria using blood samples collected in an EDTA container. Patients were tested with one Histidine rich protein-2(HRP-2) RDT (SD-Bioline) and a combination of Histidine rich protein-2(HRP-2) and Parasite lactose dehydrogenase enzyme (pLDH) RDT (CareStart). Microscopy was used as a gold standard. Out of 200 participants enrolled and screened for malaria, 200 (100%) tested positive by Microscopy, 159 (79.5%), tested positive by SD-Bioline (HRP 2 RDT) while 139 (69.5%), tested positive with the CareStart (pLDH RDT). Upon detection of the sensitivity by serially diluting the positive samples in other to decrease the parasite density; SD-Bioline was reactive at 1:4 dilution while CareStart was weekly reactive at this dilution. Although SD-Bioline showed to have a higher sensitivity than CareStart, both could be a suitable alternative to microscopy to screen endemic malaria in Nigeria.
{"title":"Evaluation of the Sensitivity of Rapid Diagnostic Test (RDT) of Malaria in Different Age and Sex Groups Using Microscopy as a Gold Standard","authors":"M. I. Shago, Markus Kirwe Jiyil, Nazifi Alhaji Sani, G. Suleiman","doi":"10.11648/J.IJIDT.20200503.21","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200503.21","url":null,"abstract":"Malaria remains a public health problem in over 90 countries worldwide, especially in Africa where it is the cause of morbidity and mortality. The aim of the study is to compare the sensitivity of two rapid diagnostic test kits in the diagnosis of malaria among patients attending Yobe State Specialist Hospital Damaturu. Patients were screened for malaria using blood samples collected in an EDTA container. Patients were tested with one Histidine rich protein-2(HRP-2) RDT (SD-Bioline) and a combination of Histidine rich protein-2(HRP-2) and Parasite lactose dehydrogenase enzyme (pLDH) RDT (CareStart). Microscopy was used as a gold standard. Out of 200 participants enrolled and screened for malaria, 200 (100%) tested positive by Microscopy, 159 (79.5%), tested positive by SD-Bioline (HRP 2 RDT) while 139 (69.5%), tested positive with the CareStart (pLDH RDT). Upon detection of the sensitivity by serially diluting the positive samples in other to decrease the parasite density; SD-Bioline was reactive at 1:4 dilution while CareStart was weekly reactive at this dilution. Although SD-Bioline showed to have a higher sensitivity than CareStart, both could be a suitable alternative to microscopy to screen endemic malaria in Nigeria.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"99"},"PeriodicalIF":0.0,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45316931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-10DOI: 10.11648/J.IJIDT.20200503.20
P. Xaplanteri, C. Potsios
The ocular surface is constantly exposed to pathogenic bacteria. Many Gram positive and Gram negative bacteria have been implicated in ocular infections, in non immunocompromised patients, causing severe vision impairment. These microorganisms have in their quiver a variety of arrows to cause infection. The aim of this study is to list the virulence factors of the main ocular pathogens. Data were extracted from PubMed and Google Scholar. S. aureus and Streptococci, Bacillus cereus and Corynebacterium (non-diphtheriae) are the main culprits as far as Gram positive bacteria are concerned. S. aureus causes infections of the lacrimal apparatus, cornea and eyelids, conjunctivitis, keratitis, and endophthalmitis. Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus and Streptococcus viridians are isolated from post injection endophthalmitis cases. S. pneumoniae is most involved in keratitis, conjunctivitis, and endophthalmitis. Streptococcus pyogenes is most involved in blepharitis and hospital acquired conjunctivitis in neonates in the intensive care unit. Enterococcus faecalis is implicated in postoperative endophthalmitis cases. Corynebacterium (non-diphtheriae) species are involved mainly in infections complicating cataract surgery, keratoplasty, and vitrectomy. Bacillus species provoke conjunctivitis, keratitis and post-traumatic endophthalmitis. Bacillus cereus can cause rapidly destructive endophthalmitis. Among Gram negative bacteria, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Chlamydia trachomatis, and Bartonella species are major ocular pathogens, responsible for severe ocular damage. Gonococcal conjunctivitis (GC) is still a cause of blindness in some developing countries. When it occurs in neonates, it is called gonococcal ophthalmia neonatorum. P. aeruginosa is related to contact lens-associated keratitis. Chlamydia trachomatis is the culprit of trachoma and inclusion conjunctivitis. Bartonella henselae causes bartonellosis or cat scratch disease, or cat scratch fever. Eye infection includes optic neuropathy and neuroretinitis. When the eye is the primary site of inoculation, the patients are diagnosed with Parinaud oculo-glandular syndrome (infection of the conjunctiva, eyelid and adjacent skin with regional lymphadenopathy). Chronic Bartonella infection provokes blurred vision, photophobia and eye irritation. Comprehension of the mechanism of infection, caused by these pathogens, is crucial in diagnosis and treatment.
{"title":"Virulence Factors of Bacteria Related to Ocular Infections in Non Immunocompromised Patients: Review Article","authors":"P. Xaplanteri, C. Potsios","doi":"10.11648/J.IJIDT.20200503.20","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200503.20","url":null,"abstract":"The ocular surface is constantly exposed to pathogenic bacteria. Many Gram positive and Gram negative bacteria have been implicated in ocular infections, in non immunocompromised patients, causing severe vision impairment. These microorganisms have in their quiver a variety of arrows to cause infection. The aim of this study is to list the virulence factors of the main ocular pathogens. Data were extracted from PubMed and Google Scholar. S. aureus and Streptococci, Bacillus cereus and Corynebacterium (non-diphtheriae) are the main culprits as far as Gram positive bacteria are concerned. S. aureus causes infections of the lacrimal apparatus, cornea and eyelids, conjunctivitis, keratitis, and endophthalmitis. Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus and Streptococcus viridians are isolated from post injection endophthalmitis cases. S. pneumoniae is most involved in keratitis, conjunctivitis, and endophthalmitis. Streptococcus pyogenes is most involved in blepharitis and hospital acquired conjunctivitis in neonates in the intensive care unit. Enterococcus faecalis is implicated in postoperative endophthalmitis cases. Corynebacterium (non-diphtheriae) species are involved mainly in infections complicating cataract surgery, keratoplasty, and vitrectomy. Bacillus species provoke conjunctivitis, keratitis and post-traumatic endophthalmitis. Bacillus cereus can cause rapidly destructive endophthalmitis. Among Gram negative bacteria, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Chlamydia trachomatis, and Bartonella species are major ocular pathogens, responsible for severe ocular damage. Gonococcal conjunctivitis (GC) is still a cause of blindness in some developing countries. When it occurs in neonates, it is called gonococcal ophthalmia neonatorum. P. aeruginosa is related to contact lens-associated keratitis. Chlamydia trachomatis is the culprit of trachoma and inclusion conjunctivitis. Bartonella henselae causes bartonellosis or cat scratch disease, or cat scratch fever. Eye infection includes optic neuropathy and neuroretinitis. When the eye is the primary site of inoculation, the patients are diagnosed with Parinaud oculo-glandular syndrome (infection of the conjunctiva, eyelid and adjacent skin with regional lymphadenopathy). Chronic Bartonella infection provokes blurred vision, photophobia and eye irritation. Comprehension of the mechanism of infection, caused by these pathogens, is crucial in diagnosis and treatment.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"92"},"PeriodicalIF":0.0,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42476815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-04DOI: 10.11648/J.IJIDT.20200503.19
Noah Noah Dominique, Eloumou Servais Albert Fiacre, Nsenga Djapa Guy Roger, Ze Meka Louis Philippe, Tayou Tagny Claude
Introduction: Chronic viral hepatitis remain a public health problem worldwide. Being the seventh leading cause of the deaths, it accounts for 1.4 million deaths annually, with 47% related to hepatitis B and 48% to hepatitis C. In Cameroon, screening for hepatitis B surface antigen (HBsAg) is mandatory by the sixth month of pregnancy. This study aimed at evaluating the carriage rate of HBsAg among pupils in the south region, 10 years after the introduction of the pentavalent vaccine in the expanded immunization programme. Material and methods: This study was conducted in schools in Ebolowa (and its neighborhoods), south of Cameroon, during the five months period from November 1st 2015 to March 17th 2016. Eight schools were randomly selected. All children less than 10 years old were enrolled in our study. Children not meeting our selection criteria, or whose data forms were appropriately filled were excluded. Sampling was done by a laboratory technician of the Ebolowa regional hospital and transferred to the laboratory of the Yaounde University Teaching Hospital for analysis. Data was analyzed using the Epi info software. Results: A total of 471 pupils met our selection criteria with a male to female ration of 0.94 (243 females against 228 males). Five children were HBsAg positive, giving an overall prevalence of 1.06%. Among the 471 pupils, only 166 were appropriately vaccinated as per the extended immunization programme, yielding 35.24% coverage. Conclusion: Despite the low immunization coverage rate, there is a positive impact on the prevalence of hepatitis B among children. Everything being equal, improving the immunization coverage as per the EPI will certainly yield lower rates of infection among children, and thus in the long run, within the general population.
{"title":"Seroprevalence of Chronic Viral Hepatitis B in School Children Aged Less Than 10 Years in the Region of Southern Cameroon","authors":"Noah Noah Dominique, Eloumou Servais Albert Fiacre, Nsenga Djapa Guy Roger, Ze Meka Louis Philippe, Tayou Tagny Claude","doi":"10.11648/J.IJIDT.20200503.19","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200503.19","url":null,"abstract":"Introduction: Chronic viral hepatitis remain a public health problem worldwide. Being the seventh leading cause of the deaths, it accounts for 1.4 million deaths annually, with 47% related to hepatitis B and 48% to hepatitis C. In Cameroon, screening for hepatitis B surface antigen (HBsAg) is mandatory by the sixth month of pregnancy. This study aimed at evaluating the carriage rate of HBsAg among pupils in the south region, 10 years after the introduction of the pentavalent vaccine in the expanded immunization programme. Material and methods: This study was conducted in schools in Ebolowa (and its neighborhoods), south of Cameroon, during the five months period from November 1st 2015 to March 17th 2016. Eight schools were randomly selected. All children less than 10 years old were enrolled in our study. Children not meeting our selection criteria, or whose data forms were appropriately filled were excluded. Sampling was done by a laboratory technician of the Ebolowa regional hospital and transferred to the laboratory of the Yaounde University Teaching Hospital for analysis. Data was analyzed using the Epi info software. Results: A total of 471 pupils met our selection criteria with a male to female ration of 0.94 (243 females against 228 males). Five children were HBsAg positive, giving an overall prevalence of 1.06%. Among the 471 pupils, only 166 were appropriately vaccinated as per the extended immunization programme, yielding 35.24% coverage. Conclusion: Despite the low immunization coverage rate, there is a positive impact on the prevalence of hepatitis B among children. Everything being equal, improving the immunization coverage as per the EPI will certainly yield lower rates of infection among children, and thus in the long run, within the general population.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"88"},"PeriodicalIF":0.0,"publicationDate":"2020-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43774271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-19DOI: 10.11648/J.IJIDT.20200503.17
Mohsin Sheraz Mughal, I. Kaur, R. Rehman, Hasan Mahmood Mirza, H. Jagdey, C. Patton, W. Ghali
Coronaviruses (CoVs) are enveloped, positive-sense RNA viruses. A novel coronavirus (nCoV) was discovered to be a cause of pneumonia outbreak in Wuhan, China in late 2019. The World Health Organization (WHO) named the disease as Coronavirus Disease 2019 (COVID-19) and declared it as a pandemic in March 2020. Since the detection of the first case of COVID-19 in the United States on January 20th, 2020 in Washington State, the pandemic is still expanding. As of July 8th, the United States (U.S.) has the maximum number (3.1 million) of confirmed COVID-19 patients. In this case series, we are presenting the clinical course of the first five confirmed COVID-19 cases admitted to a community hospital in the U.S. in the beginning of March 2020. We analyzed their clinical characteristics, pre-existing comorbidities, laboratory and radiological findings. The clinical management and outcomes are discussed alongside the literature review about current management options. In conclusion, primary management is supportive care to improve oxygenation by various methods. Safety and efficacy of treatment options including ramdesevir, IL-6 inhibitors and convalescent plasma have not yet been established and none of these is FDA approved so far. Increased age (>80 years), hypoxia at the time of presentation and pre-existing co-morbidities are likely related with poor outcomes.
{"title":"Clinical Course of Five COVID-19 Patients and Treatment Updates","authors":"Mohsin Sheraz Mughal, I. Kaur, R. Rehman, Hasan Mahmood Mirza, H. Jagdey, C. Patton, W. Ghali","doi":"10.11648/J.IJIDT.20200503.17","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200503.17","url":null,"abstract":"Coronaviruses (CoVs) are enveloped, positive-sense RNA viruses. A novel coronavirus (nCoV) was discovered to be a cause of pneumonia outbreak in Wuhan, China in late 2019. The World Health Organization (WHO) named the disease as Coronavirus Disease 2019 (COVID-19) and declared it as a pandemic in March 2020. Since the detection of the first case of COVID-19 in the United States on January 20th, 2020 in Washington State, the pandemic is still expanding. As of July 8th, the United States (U.S.) has the maximum number (3.1 million) of confirmed COVID-19 patients. In this case series, we are presenting the clinical course of the first five confirmed COVID-19 cases admitted to a community hospital in the U.S. in the beginning of March 2020. We analyzed their clinical characteristics, pre-existing comorbidities, laboratory and radiological findings. The clinical management and outcomes are discussed alongside the literature review about current management options. In conclusion, primary management is supportive care to improve oxygenation by various methods. Safety and efficacy of treatment options including ramdesevir, IL-6 inhibitors and convalescent plasma have not yet been established and none of these is FDA approved so far. Increased age (>80 years), hypoxia at the time of presentation and pre-existing co-morbidities are likely related with poor outcomes.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"74"},"PeriodicalIF":0.0,"publicationDate":"2020-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64794819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-19DOI: 10.11648/J.IJIDT.20200503.18
U. Ozioko, E. Iyidobi, O. Ozioko, I. Ozor, Chisom Mbaeze, I. Abireh
In history, pandemic outbreaks have wiped out populations as well as paved way for innovations and advances in Medicine and Public health. This study aims to ascertain the inherent knowledge gap and practice regarding the use of medical mask by healthcare workers during Covid-19 pandemic. Methods. This cross sectional survey was conducted at six tertiary hospitals within the south east Nigeria in April-June 2020 using convenient sampling method, a total of 273 respondents was enrolled in the study. A three components questionnaire comprising demographic inquiries, questions was designed to assess knowledge and practice of healthcare professionals regarding the use of medical mask. Collated data was analysed using SPSS software version 21. Result, 73.3% of the participant thought they knew the procedural steps in the use of medical mask however only 18.3% healthcare workers had good practice on the use of medical mask. Significant difference. (p<0.05) in total mean knowledge among different cadres of healthcare workers was observed and total percentage of participant with good knowledge and practice of the use of medical mask were 37% and 17.1% respectively. A weak positive correlation was also observed between knowledge and practice regarding the use of medical mask among health care professionals in south east Nigeria university teaching hospital. Conclusion: Findings from this study has reaffirmed the importance of continuous medical education thus knowledge and practice of the use of medical mask should be emphasized according to international standards to ensure they offer optimal product performance when used by healthcare professionals.
{"title":"The Pattern of Use of Medical Masks Among Health Care Professionals During Covid 19 Pandemic in South East Nigeria University Teaching Hospitals","authors":"U. Ozioko, E. Iyidobi, O. Ozioko, I. Ozor, Chisom Mbaeze, I. Abireh","doi":"10.11648/J.IJIDT.20200503.18","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200503.18","url":null,"abstract":"In history, pandemic outbreaks have wiped out populations as well as paved way for innovations and advances in Medicine and Public health. This study aims to ascertain the inherent knowledge gap and practice regarding the use of medical mask by healthcare workers during Covid-19 pandemic. Methods. This cross sectional survey was conducted at six tertiary hospitals within the south east Nigeria in April-June 2020 using convenient sampling method, a total of 273 respondents was enrolled in the study. A three components questionnaire comprising demographic inquiries, questions was designed to assess knowledge and practice of healthcare professionals regarding the use of medical mask. Collated data was analysed using SPSS software version 21. Result, 73.3% of the participant thought they knew the procedural steps in the use of medical mask however only 18.3% healthcare workers had good practice on the use of medical mask. Significant difference. (p<0.05) in total mean knowledge among different cadres of healthcare workers was observed and total percentage of participant with good knowledge and practice of the use of medical mask were 37% and 17.1% respectively. A weak positive correlation was also observed between knowledge and practice regarding the use of medical mask among health care professionals in south east Nigeria university teaching hospital. Conclusion: Findings from this study has reaffirmed the importance of continuous medical education thus knowledge and practice of the use of medical mask should be emphasized according to international standards to ensure they offer optimal product performance when used by healthcare professionals.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"81"},"PeriodicalIF":0.0,"publicationDate":"2020-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46209233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Chicken pox or varicella is an acute viral infectious disease of childhood caused by varicella-zoster virus. Humans are the only known hosts for this virus. The major route of transmission is airborne, however, transmissions via aerosols or direct contact with blister fluid have also been reported. The primary infection presents as fever and exanthematous rash. Clinically apparent infection usually provides lifelong immunity. The disease is usually acute and self-limiting but occasionally can lead to secondary infections like pneumonia, encephalitis, and secondary bacterial infections. Varicella is vaccine preventable disease. An estimated 4.2 million cases and 4200 deaths occur annually worldwide. This outbreak investigation was conducted to describe chicken pox cases in terms of person, place and time from 6th to 18th August 2018. Methods: We conducted a descriptive study in the Yirga cheffe town. We line listed all reported cases which contains sociodemographic characteristics and signs and symptoms of patients. We have also visited the reporting internally displaced population (IDP) sites during investigation. The line listed data were analyzed with person, place and time. Cases were treated symptomatically in mobile clinics. Results: A total of 25 suspected cases of chicken pox were reported between 6th and 18th of August 2018 from Yirga cheffe town IDP sites. The cases were reported from two IDP sites. Out of the total reported cases 14 (56%) were males while the remaining 11 (44%) were females with regard to sex. 88% of the total reported cases were children under the age of fifteen. Conclusion: The most affected age group in this outbreak was under the age of fifteen. Males were more affected than females in this outbreak. Unavailability of chicken pox vaccine in Ethiopia might be a risk for the occurrence of this outbreak. Strengthening routine surveillance in the IDP sites is recommended. Ministry of Health of Ethiopia should consider the introduction of chicken pox vaccine in the country. Ministry of Health should prepare guidelines and manuals for response of outbreaks.
{"title":"Suspected Chicken Pox Outbreak Investigation and Response in Yirga Chefe Town, Ethiopia, August 2018","authors":"Habtamu Tilahun, Mikias Alayu, Mekdes Demssie, Tadesse Yalew","doi":"10.11648/J.IJIDT.20200503.16","DOIUrl":"https://doi.org/10.11648/J.IJIDT.20200503.16","url":null,"abstract":"Introduction: Chicken pox or varicella is an acute viral infectious disease of childhood caused by varicella-zoster virus. Humans are the only known hosts for this virus. The major route of transmission is airborne, however, transmissions via aerosols or direct contact with blister fluid have also been reported. The primary infection presents as fever and exanthematous rash. Clinically apparent infection usually provides lifelong immunity. The disease is usually acute and self-limiting but occasionally can lead to secondary infections like pneumonia, encephalitis, and secondary bacterial infections. Varicella is vaccine preventable disease. An estimated 4.2 million cases and 4200 deaths occur annually worldwide. This outbreak investigation was conducted to describe chicken pox cases in terms of person, place and time from 6th to 18th August 2018. Methods: We conducted a descriptive study in the Yirga cheffe town. We line listed all reported cases which contains sociodemographic characteristics and signs and symptoms of patients. We have also visited the reporting internally displaced population (IDP) sites during investigation. The line listed data were analyzed with person, place and time. Cases were treated symptomatically in mobile clinics. Results: A total of 25 suspected cases of chicken pox were reported between 6th and 18th of August 2018 from Yirga cheffe town IDP sites. The cases were reported from two IDP sites. Out of the total reported cases 14 (56%) were males while the remaining 11 (44%) were females with regard to sex. 88% of the total reported cases were children under the age of fifteen. Conclusion: The most affected age group in this outbreak was under the age of fifteen. Males were more affected than females in this outbreak. Unavailability of chicken pox vaccine in Ethiopia might be a risk for the occurrence of this outbreak. Strengthening routine surveillance in the IDP sites is recommended. Ministry of Health of Ethiopia should consider the introduction of chicken pox vaccine in the country. Ministry of Health should prepare guidelines and manuals for response of outbreaks.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"5 1","pages":"70"},"PeriodicalIF":0.0,"publicationDate":"2020-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45346583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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