Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000382
C. Adawaye, E. Kamangu, J. Fokam, F. Susin, A. Moussa, Tchombou Hig-Zounet Bertin, Joseph Mad-Toingue, D. Vaira, M. Moutschen
Introduction: Antiretroviral therapy is effective only when it maintains the plasma viral load at an undetectable level or below 50 copies of RNA/ml. Viral Load (VL) is a marker of therapeutic follow-up, particularly within the combination protocols of antivirals. Given the genetic diversity of HIV-1, in Resource-Limited Countries (RLCs), dubious conditions for collecting, conserving and analyzing samples, the choice of one technique over another implies its evaluation on all levels and in particular the cost/benefit ratio. Objective: The objective of this study was to compare the efficacy of 3 techniques for the measurement of VL for HIV-1 non-B subtypes. The 3 techniques used were: Cobas AmpliPrep/Cobas TaqMan (CAP/CTM) V2.0, Abbott Real-Time and Generic HIV Viral Load®. Methods: Sample collection was done at the National General Reference Hospital (NGRH) between June and October 2013. A total of 116 samples were collected from People Living with HIV (PLHIV) and under treatment for at least 6 months. Measurements of VL were done at the AIDS Reference Laboratory at the University Hospital of Liège with the 3 techniques mentioned above. Results: After amplification by the different techniques, 116 samples were compared with Cobas and Abbott and 42 samples were compared with all 3 techniques. This is due to the lack of plasma for some patients for the Generic HIV Viral Load®. A good correlation is obtained between CAP/CTM and Abbott with R2=0.96016 (p<0.05), while between Abbott vs Generic HIV Viral Load® on one hand and CAP/CTM vs Generic HIV Viral Load® on the other, Pearson correlations (R2) were good and were respectively 0.81064 and 0.72603. This difference with the Generic HIV Viral Load® assay is due to the fact that the plasma has been thawed more than twice. This confirms the fact that plasma freezing, and thawing has more than twice interferes with viral load. Conclusions: Abbott Real time remains the recommended technique for resource-poor countries, particularly Chad, because of its sensitivity and variability in detecting different subtypes of HIV-1.
导读:抗逆转录病毒治疗只有在将血浆病毒载量维持在检测不到的水平或低于50拷贝RNA/ml时才有效。病毒载量(VL)是治疗随访的标志，特别是在抗病毒药物联合方案中。鉴于HIV-1的遗传多样性，在资源有限的国家(rlc)，收集、保存和分析样本的条件可疑，选择一种技术而不是另一种技术意味着在所有层面上进行评估，特别是成本/效益比。目的:本研究的目的是比较3种技术测量HIV-1非b亚型的VL的效果。使用的3种技术是:Cobas AmpliPrep/Cobas TaqMan (CAP/CTM) V2.0, Abbott Real-Time和Generic HIV Viral Load®。方法:2013年6 - 10月在国家综合参考医院(NGRH)采集样本。总共从接受治疗至少6个月的艾滋病毒感染者(PLHIV)中收集了116个样本。VL的测量是在利维奇大学医院艾滋病参考实验室用上述3种技术完成的。结果:经不同技术扩增后，116份样品与Cobas和Abbott进行比较，42份样品与3种技术进行比较。这是由于缺乏血浆的一些患者为通用HIV病毒载量®。CAP/CTM与雅培具有较好的相关性，R2=0.96016 (p<0.05)，而雅培与Generic HIV Viral Load®、CAP/CTM与Generic HIV Viral Load®的Pearson相关性(R2)较好，分别为0.81064和0.72603。与Generic HIV Viral Load®检测的差异是由于血浆已经解冻两次以上。这证实了血浆冷冻和解冻对病毒载量的干扰超过两倍的事实。结论:雅培实时仍然是资源贫乏国家，特别是乍得的推荐技术，因为它在检测不同亚型HIV-1的敏感性和可变性。
{"title":"Comparison of 3 Tests for Plasma HIV-1 RNA Quantitation of Non-B Subtypes in Patients Infected with HIV-1 in N’Djamena-Chad: Cobas AmpliPrep/Cobas TaqMan HIV-1 Test Version 2.0, Abbott m2000 RealTime and Generic HIV Viral Load® Assays","authors":"C. Adawaye, E. Kamangu, J. Fokam, F. Susin, A. Moussa, Tchombou Hig-Zounet Bertin, Joseph Mad-Toingue, D. Vaira, M. Moutschen","doi":"10.4172/2332-0877.1000382","DOIUrl":"https://doi.org/10.4172/2332-0877.1000382","url":null,"abstract":"Introduction: Antiretroviral therapy is effective only when it maintains the plasma viral load at an undetectable level or below 50 copies of RNA/ml. Viral Load (VL) is a marker of therapeutic follow-up, particularly within the combination protocols of antivirals. Given the genetic diversity of HIV-1, in Resource-Limited Countries (RLCs), dubious conditions for collecting, conserving and analyzing samples, the choice of one technique over another implies its evaluation on all levels and in particular the cost/benefit ratio. Objective: The objective of this study was to compare the efficacy of 3 techniques for the measurement of VL for HIV-1 non-B subtypes. The 3 techniques used were: Cobas AmpliPrep/Cobas TaqMan (CAP/CTM) V2.0, Abbott Real-Time and Generic HIV Viral Load®. Methods: Sample collection was done at the National General Reference Hospital (NGRH) between June and October 2013. A total of 116 samples were collected from People Living with HIV (PLHIV) and under treatment for at least 6 months. Measurements of VL were done at the AIDS Reference Laboratory at the University Hospital of Liège with the 3 techniques mentioned above. Results: After amplification by the different techniques, 116 samples were compared with Cobas and Abbott and 42 samples were compared with all 3 techniques. This is due to the lack of plasma for some patients for the Generic HIV Viral Load®. A good correlation is obtained between CAP/CTM and Abbott with R2=0.96016 (p<0.05), while between Abbott vs Generic HIV Viral Load® on one hand and CAP/CTM vs Generic HIV Viral Load® on the other, Pearson correlations (R2) were good and were respectively 0.81064 and 0.72603. This difference with the Generic HIV Viral Load® assay is due to the fact that the plasma has been thawed more than twice. This confirms the fact that plasma freezing, and thawing has more than twice interferes with viral load. Conclusions: Abbott Real time remains the recommended technique for resource-poor countries, particularly Chad, because of its sensitivity and variability in detecting different subtypes of HIV-1.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000385
E. Sarıçam, Yasemin Saglam
{"title":"The Seasonal Pattern of Acute Pericarditis and Concurrence of Recurrent Pericarditis with Vitamin D Deficiency","authors":"E. Sarıçam, Yasemin Saglam","doi":"10.4172/2332-0877.1000385","DOIUrl":"https://doi.org/10.4172/2332-0877.1000385","url":null,"abstract":"","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000386
A. Oudghiri, I. Chaoui, M. Elmzibri
{"title":"Molecular Epidemiology of Tuberculosis: A Review of Tools and Applications","authors":"A. Oudghiri, I. Chaoui, M. Elmzibri","doi":"10.4172/2332-0877.1000386","DOIUrl":"https://doi.org/10.4172/2332-0877.1000386","url":null,"abstract":"","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000386","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000369
F. Căruntu, A. Barbu, A. Ciobotaru, M. Radu
Introduction: Tuberculosis continues to pose a problem of public health worldwide. Mycobacterium tuberculosis infects 1/3 of the world's population and seems to be responsible for 1.4 million deaths annually. In our country, the incidence is 6.5 times higher than in the EU countries. In 2016 there were 12836 cases of pulmonary TB (new and recurrent cases) of which 530 cases were TB MDR/XDR. The screening rate increased to 94% for new cases and 85% for MDR tuberculosis cases. Extrapulmonary tuberculosis remains a challenge by delaying of the diagnosis and the duration of treatment.Case presentation: We present the case of a 73-year-old patient with no significant pathological history admitted to the National Institute for Infectious Diseases “Prof. Dr. Matei Bals”, Bucharest, in July 2017 (21 days) for myalgia and fever apparently after an episode of a respiratory tract infection. Due to myalgia, the occurrence of muscular atrophy and accelerate weight loss he referred to our hospital where was established the diagnosis of Tuberculous Spondylitis.Results and methods: The diagnosis was established following numerous clinical and paraclinical investigations approximately 6 weeks after the first presentation to our hospital. As risk factors, the patient was diagnosed by the time of admission with other diseases that he wasn’t aware of as diabetes and renal impairment. Evolution under anti-tuberculosis treatment was arduous due to the development of hepatic toxicity, episodes of acute exacerbation of chronic renal disease and post-antibiotic diarrhoea. The final clinical and paraclinical outcome was favourable.Discussion: Diagnosis of TB spondylitis requires both multidisciplinary collaborations and diagnosis experience. Anamnesis and understanding of symptoms are also important for proper selecting paraclinical tests panel. To understand these results in view of imposing a nephrotoxic and hepatotoxic treatment in the patient with pre-existing liver and kidney pathology, we returned to understanding the pathophysiology of Tuberculous Spondylitis.Conclusions: Diagnosing the vertebral location of extrapulmonary tuberculosis requires understanding pathophysiology of this infection. Requesting of paraclinical investigation and performing differential diagnostics can help shorten the time required for diagnosis.
{"title":"Tuberculous Spondylitis. Burden of Diagnosis. Case Presentation","authors":"F. Căruntu, A. Barbu, A. Ciobotaru, M. Radu","doi":"10.4172/2332-0877.1000369","DOIUrl":"https://doi.org/10.4172/2332-0877.1000369","url":null,"abstract":"Introduction: Tuberculosis continues to pose a problem of public health worldwide. Mycobacterium tuberculosis infects 1/3 of the world's population and seems to be responsible for 1.4 million deaths annually. In our country, the incidence is 6.5 times higher than in the EU countries. In 2016 there were 12836 cases of pulmonary TB (new and recurrent cases) of which 530 cases were TB MDR/XDR. The screening rate increased to 94% for new cases and 85% for MDR tuberculosis cases. Extrapulmonary tuberculosis remains a challenge by delaying of the diagnosis and the duration of treatment.Case presentation: We present the case of a 73-year-old patient with no significant pathological history admitted to the National Institute for Infectious Diseases “Prof. Dr. Matei Bals”, Bucharest, in July 2017 (21 days) for myalgia and fever apparently after an episode of a respiratory tract infection. Due to myalgia, the occurrence of muscular atrophy and accelerate weight loss he referred to our hospital where was established the diagnosis of Tuberculous Spondylitis.Results and methods: The diagnosis was established following numerous clinical and paraclinical investigations approximately 6 weeks after the first presentation to our hospital. As risk factors, the patient was diagnosed by the time of admission with other diseases that he wasn’t aware of as diabetes and renal impairment. Evolution under anti-tuberculosis treatment was arduous due to the development of hepatic toxicity, episodes of acute exacerbation of chronic renal disease and post-antibiotic diarrhoea. The final clinical and paraclinical outcome was favourable.Discussion: Diagnosis of TB spondylitis requires both multidisciplinary collaborations and diagnosis experience. Anamnesis and understanding of symptoms are also important for proper selecting paraclinical tests panel. To understand these results in view of imposing a nephrotoxic and hepatotoxic treatment in the patient with pre-existing liver and kidney pathology, we returned to understanding the pathophysiology of Tuberculous Spondylitis.Conclusions: Diagnosing the vertebral location of extrapulmonary tuberculosis requires understanding pathophysiology of this infection. Requesting of paraclinical investigation and performing differential diagnostics can help shorten the time required for diagnosis.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000358
Sonda Ka, J. Zoungrana, M. Savadogo, Hien Sjm, I. Diallo, A. Poda, Ouédraogo Ag, E. Diendéré, Sanou As, Ngaha La, M. Kaboré, C. Kyelem, M. Ouédraogo, Y. Drabo
Introduction/Mission: In Burkina Faso, tetanus remains a public health problem. The aim of the study was to describe the epidemiological, clinical and evolutionary profile of tetanus at the Yalgado University Hospital Center in Ouagadougou. Patients and methods: We conducted a descriptive cross-sectional study of tetanus cases admitted in the department of infectious diseases from January 2000 to June 2014. The data were collected from the clinical records of hospitalized patients. Results: The frequency of tetanus in the hospital was 2.6% and the average admission was 10.2 cases per year. Of the 92 cases of tetanus reported, the mean age was 29.2 ± 18.8 years. The group age of 15-45 accounted for 62% of the patients. Farmers (36.5%), unemployed (28.5%) and informal sector workers (21.5%) were the most represented occupations. The patients were mostly unvaccinated against tetanus (97.8%). The main points of entry were integumentary (68%) and surgical (16.5%). Complications were mostly infectious (14%) and the lethality was 35.5%. Conclusion: Tetanus is endemic in Burkina Faso and affects the active layer of the population. Sensitization of populations on the interest of anti-tetanus prophylaxis is essential.
{"title":"Tetanus at Yalgado Ouédraogo University Hospital Center in Ouagadougou from 2000 to 2014","authors":"Sonda Ka, J. Zoungrana, M. Savadogo, Hien Sjm, I. Diallo, A. Poda, Ouédraogo Ag, E. Diendéré, Sanou As, Ngaha La, M. Kaboré, C. Kyelem, M. Ouédraogo, Y. Drabo","doi":"10.4172/2332-0877.1000358","DOIUrl":"https://doi.org/10.4172/2332-0877.1000358","url":null,"abstract":"Introduction/Mission: In Burkina Faso, tetanus remains a public health problem. The aim of the study was to describe the epidemiological, clinical and evolutionary profile of tetanus at the Yalgado University Hospital Center in Ouagadougou. Patients and methods: We conducted a descriptive cross-sectional study of tetanus cases admitted in the department of infectious diseases from January 2000 to June 2014. The data were collected from the clinical records of hospitalized patients. Results: The frequency of tetanus in the hospital was 2.6% and the average admission was 10.2 cases per year. Of the 92 cases of tetanus reported, the mean age was 29.2 ± 18.8 years. The group age of 15-45 accounted for 62% of the patients. Farmers (36.5%), unemployed (28.5%) and informal sector workers (21.5%) were the most represented occupations. The patients were mostly unvaccinated against tetanus (97.8%). The main points of entry were integumentary (68%) and surgical (16.5%). Complications were mostly infectious (14%) and the lethality was 35.5%. Conclusion: Tetanus is endemic in Burkina Faso and affects the active layer of the population. Sensitization of populations on the interest of anti-tetanus prophylaxis is essential.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000358","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000360
Y. Tsutsumi, Yoshiya Yamamoto, S. Ito, T. Sekine, S. Matsuoka, H. Naruse, T. Teshima
Since there is a suggested a link between HCV and liver cancer, attempts are currently being made to discover new drugs that can advance the treatment of hepatitis C and prevent it from progressing to liver cancer. On the other hand, in the treatment of lymphoma, it has been pointed out that HCV is associated with HCV reactivation and lymphoproliferative diseases such as lymphoma. In this review, we will summarize the relationship between lymphoproliferative diseases and hepatitis due to reactivation of HCV during treatment with rituximab.
{"title":"HCV Infection on Lymphoid Neoplasm","authors":"Y. Tsutsumi, Yoshiya Yamamoto, S. Ito, T. Sekine, S. Matsuoka, H. Naruse, T. Teshima","doi":"10.4172/2332-0877.1000360","DOIUrl":"https://doi.org/10.4172/2332-0877.1000360","url":null,"abstract":"Since there is a suggested a link between HCV and liver cancer, attempts are currently being made to discover new drugs that can advance the treatment of hepatitis C and prevent it from progressing to liver cancer. On the other hand, in the treatment of lymphoma, it has been pointed out that HCV is associated with HCV reactivation and lymphoproliferative diseases such as lymphoma. In this review, we will summarize the relationship between lymphoproliferative diseases and hepatitis due to reactivation of HCV during treatment with rituximab.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000365
Devendar Vadthyavath, P. Muragundi
Extensively Drug-Resistant Tuberculosis (XDR-TB) is a recent challenge for tuberculosis control program. The absence of the functional drugs and high rate of the failure in treatment and mortality rate also high jeopardize for epidemiology. Its prevalence is unknown in India as there was no nationwide counselling. Globally, there were an estimated 55,100 new extensively drug resistant tuberculosis cases in the year of 2015 in 117 countries. However, only 30 cases extensively drug-resistant tuberculosis was reported. Drug susceptibility test (DST) is the cornerstone to diagnose extensively drug resistant tuberculosis, but the lack of laboratory facilities in the resource-limited endemic countries limits its uses. A few new drugs including bedaquiline and delamanid have the potential to improve the efficiency of extensively drug-resistant tuberculosis treatment, but those drugs are used in 39 countries only. The costs of extensively drug resistant tuberculosis treatment (XDR-TB) are several folds higher than then multi drug-resistant tuberculosis (MDR-TB).
{"title":"Extensively Drug-Resistant Tuberculosis in India: Prevalence, Incidence and Burden","authors":"Devendar Vadthyavath, P. Muragundi","doi":"10.4172/2332-0877.1000365","DOIUrl":"https://doi.org/10.4172/2332-0877.1000365","url":null,"abstract":"Extensively Drug-Resistant Tuberculosis (XDR-TB) is a recent challenge for tuberculosis control program. The absence of the functional drugs and high rate of the failure in treatment and mortality rate also high jeopardize for epidemiology. Its prevalence is unknown in India as there was no nationwide counselling. Globally, there were an estimated 55,100 new extensively drug resistant tuberculosis cases in the year of 2015 in 117 countries. However, only 30 cases extensively drug-resistant tuberculosis was reported. Drug susceptibility test (DST) is the cornerstone to diagnose extensively drug resistant tuberculosis, but the lack of laboratory facilities in the resource-limited endemic countries limits its uses. A few new drugs including bedaquiline and delamanid have the potential to improve the efficiency of extensively drug-resistant tuberculosis treatment, but those drugs are used in 39 countries only. The costs of extensively drug resistant tuberculosis treatment (XDR-TB) are several folds higher than then multi drug-resistant tuberculosis (MDR-TB).","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000349
C. Amado, M. Pérez
Hypovitaminosis D is highly prevalent worldwide [1]. Vitamin D importance is well known in bone diseases, but its role in infectious diseases has been recognised recently [2]. The main source of vitamin D is endogenous production in the skin under the influence of sun light. In the liver all vitamin D is hydroxylated to 25 hydroxyvitamin D (25OHD), which is the major circulating form of vitamin D, so serum levels of 25OHD are considered the best marker of nutritional vitamin D status. Under the control of feedback mechanisms 25OHD is hydroxylated in the kidney to the circulating hormone 1,25 (OH)2 D (calcitriol). Circulating calcitriol regulates calcium metabolism (“classical endocrine pathway of vitamin D”).
{"title":"Vitamin D Nutritional Status and Infectious Diseases","authors":"C. Amado, M. Pérez","doi":"10.4172/2332-0877.1000349","DOIUrl":"https://doi.org/10.4172/2332-0877.1000349","url":null,"abstract":"Hypovitaminosis D is highly prevalent worldwide [1]. Vitamin D importance is well known in bone diseases, but its role in infectious diseases has been recognised recently [2]. The main source of vitamin D is endogenous production in the skin under the influence of sun light. In the liver all vitamin D is hydroxylated to 25 hydroxyvitamin D (25OHD), which is the major circulating form of vitamin D, so serum levels of 25OHD are considered the best marker of nutritional vitamin D status. Under the control of feedback mechanisms 25OHD is hydroxylated in the kidney to the circulating hormone 1,25 (OH)2 D (calcitriol). Circulating calcitriol regulates calcium metabolism (“classical endocrine pathway of vitamin D”).","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000374
S. Na, D. Surov, I. Soloviev, A. Demko, Babkov Ov, G. V. Martynova, A. V. Sviatnenko, A. V. Osipov, B. Bezmozgin, Luk'ianiuk Pp
Over the last years, the number of publications devoted to the concept of enhanced recovery after surgery (ERAS) in emergency abdominal surgery application increases. The purpose of this study was a comparative analysis of the results of the ERAS-program application in surgical treatment of the patients with colorectal cancer complicated by large bowel obstruction (LBO). The study included 89 patients with obstructive colorectal carcinoma (OCRC), divided in the ERAS and control group (n=45 and n=44, respectively). During the treatment of the patients of the ERAS group in preoperative period, the following measures were taken: patient information, his psychological preparation, prevention of postoperative pain, nausea and vomiting, thromboembolic and infectious complications. Intraoperative measures included local anaesthesia of the skin in the line of laparotomy access, colon and small (under indications) intestines decompression, small intestine lavage, embryology oriented surgery and D3 lymphadenectomy, temporary installation of polyurethane catheter distal to the ligament of Treitz for early enteral nutrition, rectus sheath catheterization to carry out rectus sheath block of the anterior branches of the spinal nerves, control drainage installation into the small pelvis. In postoperative period, the early mobilization, urinary catheter and drainage removal after the patient transfer from intensive care unit were carried out. The following criteria were used as the criteria for comparative evaluation: pain syndrome intensity, need for analgesics, time of enteric deficiency arresting, postoperative complications and mortality, postoperative period duration, and patients' life quality after discharge from the hospital. It has been established that the proposed original ERAS program for this category of the patients is safe and effective due to improving the immediate results of surgical treatment.
{"title":"Application of the Program of Enhanced Recovery in Surgical Treatment of Patients with Colorectal Cancer Complicated by Acute Obstruction (Our Experience)","authors":"S. Na, D. Surov, I. Soloviev, A. Demko, Babkov Ov, G. V. Martynova, A. V. Sviatnenko, A. V. Osipov, B. Bezmozgin, Luk'ianiuk Pp","doi":"10.4172/2332-0877.1000374","DOIUrl":"https://doi.org/10.4172/2332-0877.1000374","url":null,"abstract":"Over the last years, the number of publications devoted to the concept of enhanced recovery after surgery (ERAS) in emergency abdominal surgery application increases. The purpose of this study was a comparative analysis of the results of the ERAS-program application in surgical treatment of the patients with colorectal cancer complicated by large bowel obstruction (LBO). The study included 89 patients with obstructive colorectal carcinoma (OCRC), divided in the ERAS and control group (n=45 and n=44, respectively). During the treatment of the patients of the ERAS group in preoperative period, the following measures were taken: patient information, his psychological preparation, prevention of postoperative pain, nausea and vomiting, thromboembolic and infectious complications. Intraoperative measures included local anaesthesia of the skin in the line of laparotomy access, colon and small (under indications) intestines decompression, small intestine lavage, embryology oriented surgery and D3 lymphadenectomy, temporary installation of polyurethane catheter distal to the ligament of Treitz for early enteral nutrition, rectus sheath catheterization to carry out rectus sheath block of the anterior branches of the spinal nerves, control drainage installation into the small pelvis. In postoperative period, the early mobilization, urinary catheter and drainage removal after the patient transfer from intensive care unit were carried out. The following criteria were used as the criteria for comparative evaluation: pain syndrome intensity, need for analgesics, time of enteric deficiency arresting, postoperative complications and mortality, postoperative period duration, and patients' life quality after discharge from the hospital. It has been established that the proposed original ERAS program for this category of the patients is safe and effective due to improving the immediate results of surgical treatment.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000376
Mohamed Ibrahim El Gharee, Mohamed Khate, A. Adel
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