Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000386
A. Oudghiri, I. Chaoui, M. Elmzibri
{"title":"Molecular Epidemiology of Tuberculosis: A Review of Tools and Applications","authors":"A. Oudghiri, I. Chaoui, M. Elmzibri","doi":"10.4172/2332-0877.1000386","DOIUrl":"https://doi.org/10.4172/2332-0877.1000386","url":null,"abstract":"","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"06 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000386","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000375
N. Gjermeni, D. Kraja, N. Çomo, A. Harxhi, P. Pipero, A. Simaku
: Introduction: Spondylodiscites treatment is one of the most difficult aspect of Infectious Rachiditis (IR) management. The aim of the study is to recognize the efficacy of drug therapy and associated side effects of the treatment of IR. Material and methods: The study included 103 patients who presented to Service of Infectious Diseases, at University Hospital Centre in Tirana, Albania over the period January 2006 – December 2015. The diagnosis of infectious rachiditis was made according to clinical, radiological and microbiological criteria. Results: The mean age of patients was 58.1(±10.4) years with a range 16-75 years. 62% were males and 38% females. Male to female ratio is 1.6:1. The clinical neurological signs of patients are presented in table 1. Spondilodiscitis and discitis were most frequent signs in 37.9% and 16.5% patients respectively (p<0.01). Side effects were manifested in 56 (54.4%) of patients. Most frequent ones were gastrointestinal disturbances (17.5%), dermatoses (9.7%), hepatopathy (7.8%), glossitis (4.9%). Two cases (1.9%) had a fatal outcome, one of them had a periaortal abscess complicated to septic shock, while the other case suffered also from acquired immunodeficiency syndrome. Sequelae manifested 4 (3.9%) of the total patients. One case developed tetraplegia, two cases (1.9%) developed inferior unilateral paraplegia, one case (1%) had neurogenic bladder. Two (1.9%) cases manifested relapse of the disease. These findings are similar to those presented in different studies sugesting that IR treatment is a complex and a significant issue in many countries.
{"title":"Clinical Response to Treatment of Infectious Rachiditis","authors":"N. Gjermeni, D. Kraja, N. Çomo, A. Harxhi, P. Pipero, A. Simaku","doi":"10.4172/2332-0877.1000375","DOIUrl":"https://doi.org/10.4172/2332-0877.1000375","url":null,"abstract":": Introduction: Spondylodiscites treatment is one of the most difficult aspect of Infectious Rachiditis (IR) management. The aim of the study is to recognize the efficacy of drug therapy and associated side effects of the treatment of IR. Material and methods: The study included 103 patients who presented to Service of Infectious Diseases, at University Hospital Centre in Tirana, Albania over the period January 2006 – December 2015. The diagnosis of infectious rachiditis was made according to clinical, radiological and microbiological criteria. Results: The mean age of patients was 58.1(±10.4) years with a range 16-75 years. 62% were males and 38% females. Male to female ratio is 1.6:1. The clinical neurological signs of patients are presented in table 1. Spondilodiscitis and discitis were most frequent signs in 37.9% and 16.5% patients respectively (p<0.01). Side effects were manifested in 56 (54.4%) of patients. Most frequent ones were gastrointestinal disturbances (17.5%), dermatoses (9.7%), hepatopathy (7.8%), glossitis (4.9%). Two cases (1.9%) had a fatal outcome, one of them had a periaortal abscess complicated to septic shock, while the other case suffered also from acquired immunodeficiency syndrome. Sequelae manifested 4 (3.9%) of the total patients. One case developed tetraplegia, two cases (1.9%) developed inferior unilateral paraplegia, one case (1%) had neurogenic bladder. Two (1.9%) cases manifested relapse of the disease. These findings are similar to those presented in different studies sugesting that IR treatment is a complex and a significant issue in many countries.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"06 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000375","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000385
E. Sarıçam, Yasemin Saglam
{"title":"The Seasonal Pattern of Acute Pericarditis and Concurrence of Recurrent Pericarditis with Vitamin D Deficiency","authors":"E. Sarıçam, Yasemin Saglam","doi":"10.4172/2332-0877.1000385","DOIUrl":"https://doi.org/10.4172/2332-0877.1000385","url":null,"abstract":"","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"06 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000369
F. Căruntu, A. Barbu, A. Ciobotaru, M. Radu
Introduction: Tuberculosis continues to pose a problem of public health worldwide. Mycobacterium tuberculosis infects 1/3 of the world's population and seems to be responsible for 1.4 million deaths annually. In our country, the incidence is 6.5 times higher than in the EU countries. In 2016 there were 12836 cases of pulmonary TB (new and recurrent cases) of which 530 cases were TB MDR/XDR. The screening rate increased to 94% for new cases and 85% for MDR tuberculosis cases. Extrapulmonary tuberculosis remains a challenge by delaying of the diagnosis and the duration of treatment.Case presentation: We present the case of a 73-year-old patient with no significant pathological history admitted to the National Institute for Infectious Diseases “Prof. Dr. Matei Bals”, Bucharest, in July 2017 (21 days) for myalgia and fever apparently after an episode of a respiratory tract infection. Due to myalgia, the occurrence of muscular atrophy and accelerate weight loss he referred to our hospital where was established the diagnosis of Tuberculous Spondylitis.Results and methods: The diagnosis was established following numerous clinical and paraclinical investigations approximately 6 weeks after the first presentation to our hospital. As risk factors, the patient was diagnosed by the time of admission with other diseases that he wasn’t aware of as diabetes and renal impairment. Evolution under anti-tuberculosis treatment was arduous due to the development of hepatic toxicity, episodes of acute exacerbation of chronic renal disease and post-antibiotic diarrhoea. The final clinical and paraclinical outcome was favourable.Discussion: Diagnosis of TB spondylitis requires both multidisciplinary collaborations and diagnosis experience. Anamnesis and understanding of symptoms are also important for proper selecting paraclinical tests panel. To understand these results in view of imposing a nephrotoxic and hepatotoxic treatment in the patient with pre-existing liver and kidney pathology, we returned to understanding the pathophysiology of Tuberculous Spondylitis.Conclusions: Diagnosing the vertebral location of extrapulmonary tuberculosis requires understanding pathophysiology of this infection. Requesting of paraclinical investigation and performing differential diagnostics can help shorten the time required for diagnosis.
{"title":"Tuberculous Spondylitis. Burden of Diagnosis. Case Presentation","authors":"F. Căruntu, A. Barbu, A. Ciobotaru, M. Radu","doi":"10.4172/2332-0877.1000369","DOIUrl":"https://doi.org/10.4172/2332-0877.1000369","url":null,"abstract":"Introduction: Tuberculosis continues to pose a problem of public health worldwide. Mycobacterium tuberculosis infects 1/3 of the world's population and seems to be responsible for 1.4 million deaths annually. In our country, the incidence is 6.5 times higher than in the EU countries. In 2016 there were 12836 cases of pulmonary TB (new and recurrent cases) of which 530 cases were TB MDR/XDR. The screening rate increased to 94% for new cases and 85% for MDR tuberculosis cases. Extrapulmonary tuberculosis remains a challenge by delaying of the diagnosis and the duration of treatment.Case presentation: We present the case of a 73-year-old patient with no significant pathological history admitted to the National Institute for Infectious Diseases “Prof. Dr. Matei Bals”, Bucharest, in July 2017 (21 days) for myalgia and fever apparently after an episode of a respiratory tract infection. Due to myalgia, the occurrence of muscular atrophy and accelerate weight loss he referred to our hospital where was established the diagnosis of Tuberculous Spondylitis.Results and methods: The diagnosis was established following numerous clinical and paraclinical investigations approximately 6 weeks after the first presentation to our hospital. As risk factors, the patient was diagnosed by the time of admission with other diseases that he wasn’t aware of as diabetes and renal impairment. Evolution under anti-tuberculosis treatment was arduous due to the development of hepatic toxicity, episodes of acute exacerbation of chronic renal disease and post-antibiotic diarrhoea. The final clinical and paraclinical outcome was favourable.Discussion: Diagnosis of TB spondylitis requires both multidisciplinary collaborations and diagnosis experience. Anamnesis and understanding of symptoms are also important for proper selecting paraclinical tests panel. To understand these results in view of imposing a nephrotoxic and hepatotoxic treatment in the patient with pre-existing liver and kidney pathology, we returned to understanding the pathophysiology of Tuberculous Spondylitis.Conclusions: Diagnosing the vertebral location of extrapulmonary tuberculosis requires understanding pathophysiology of this infection. Requesting of paraclinical investigation and performing differential diagnostics can help shorten the time required for diagnosis.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000358
Sonda Ka, J. Zoungrana, M. Savadogo, Hien Sjm, I. Diallo, A. Poda, Ouédraogo Ag, E. Diendéré, Sanou As, Ngaha La, M. Kaboré, C. Kyelem, M. Ouédraogo, Y. Drabo
Introduction/Mission: In Burkina Faso, tetanus remains a public health problem. The aim of the study was to describe the epidemiological, clinical and evolutionary profile of tetanus at the Yalgado University Hospital Center in Ouagadougou. Patients and methods: We conducted a descriptive cross-sectional study of tetanus cases admitted in the department of infectious diseases from January 2000 to June 2014. The data were collected from the clinical records of hospitalized patients. Results: The frequency of tetanus in the hospital was 2.6% and the average admission was 10.2 cases per year. Of the 92 cases of tetanus reported, the mean age was 29.2 ± 18.8 years. The group age of 15-45 accounted for 62% of the patients. Farmers (36.5%), unemployed (28.5%) and informal sector workers (21.5%) were the most represented occupations. The patients were mostly unvaccinated against tetanus (97.8%). The main points of entry were integumentary (68%) and surgical (16.5%). Complications were mostly infectious (14%) and the lethality was 35.5%. Conclusion: Tetanus is endemic in Burkina Faso and affects the active layer of the population. Sensitization of populations on the interest of anti-tetanus prophylaxis is essential.
{"title":"Tetanus at Yalgado Ouédraogo University Hospital Center in Ouagadougou from 2000 to 2014","authors":"Sonda Ka, J. Zoungrana, M. Savadogo, Hien Sjm, I. Diallo, A. Poda, Ouédraogo Ag, E. Diendéré, Sanou As, Ngaha La, M. Kaboré, C. Kyelem, M. Ouédraogo, Y. Drabo","doi":"10.4172/2332-0877.1000358","DOIUrl":"https://doi.org/10.4172/2332-0877.1000358","url":null,"abstract":"Introduction/Mission: In Burkina Faso, tetanus remains a public health problem. The aim of the study was to describe the epidemiological, clinical and evolutionary profile of tetanus at the Yalgado University Hospital Center in Ouagadougou. Patients and methods: We conducted a descriptive cross-sectional study of tetanus cases admitted in the department of infectious diseases from January 2000 to June 2014. The data were collected from the clinical records of hospitalized patients. Results: The frequency of tetanus in the hospital was 2.6% and the average admission was 10.2 cases per year. Of the 92 cases of tetanus reported, the mean age was 29.2 ± 18.8 years. The group age of 15-45 accounted for 62% of the patients. Farmers (36.5%), unemployed (28.5%) and informal sector workers (21.5%) were the most represented occupations. The patients were mostly unvaccinated against tetanus (97.8%). The main points of entry were integumentary (68%) and surgical (16.5%). Complications were mostly infectious (14%) and the lethality was 35.5%. Conclusion: Tetanus is endemic in Burkina Faso and affects the active layer of the population. Sensitization of populations on the interest of anti-tetanus prophylaxis is essential.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"6 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000358","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000360
Y. Tsutsumi, Yoshiya Yamamoto, S. Ito, T. Sekine, S. Matsuoka, H. Naruse, T. Teshima
Since there is a suggested a link between HCV and liver cancer, attempts are currently being made to discover new drugs that can advance the treatment of hepatitis C and prevent it from progressing to liver cancer. On the other hand, in the treatment of lymphoma, it has been pointed out that HCV is associated with HCV reactivation and lymphoproliferative diseases such as lymphoma. In this review, we will summarize the relationship between lymphoproliferative diseases and hepatitis due to reactivation of HCV during treatment with rituximab.
{"title":"HCV Infection on Lymphoid Neoplasm","authors":"Y. Tsutsumi, Yoshiya Yamamoto, S. Ito, T. Sekine, S. Matsuoka, H. Naruse, T. Teshima","doi":"10.4172/2332-0877.1000360","DOIUrl":"https://doi.org/10.4172/2332-0877.1000360","url":null,"abstract":"Since there is a suggested a link between HCV and liver cancer, attempts are currently being made to discover new drugs that can advance the treatment of hepatitis C and prevent it from progressing to liver cancer. On the other hand, in the treatment of lymphoma, it has been pointed out that HCV is associated with HCV reactivation and lymphoproliferative diseases such as lymphoma. In this review, we will summarize the relationship between lymphoproliferative diseases and hepatitis due to reactivation of HCV during treatment with rituximab.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"56 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000365
Devendar Vadthyavath, P. Muragundi
Extensively Drug-Resistant Tuberculosis (XDR-TB) is a recent challenge for tuberculosis control program. The absence of the functional drugs and high rate of the failure in treatment and mortality rate also high jeopardize for epidemiology. Its prevalence is unknown in India as there was no nationwide counselling. Globally, there were an estimated 55,100 new extensively drug resistant tuberculosis cases in the year of 2015 in 117 countries. However, only 30 cases extensively drug-resistant tuberculosis was reported. Drug susceptibility test (DST) is the cornerstone to diagnose extensively drug resistant tuberculosis, but the lack of laboratory facilities in the resource-limited endemic countries limits its uses. A few new drugs including bedaquiline and delamanid have the potential to improve the efficiency of extensively drug-resistant tuberculosis treatment, but those drugs are used in 39 countries only. The costs of extensively drug resistant tuberculosis treatment (XDR-TB) are several folds higher than then multi drug-resistant tuberculosis (MDR-TB).
{"title":"Extensively Drug-Resistant Tuberculosis in India: Prevalence, Incidence and Burden","authors":"Devendar Vadthyavath, P. Muragundi","doi":"10.4172/2332-0877.1000365","DOIUrl":"https://doi.org/10.4172/2332-0877.1000365","url":null,"abstract":"Extensively Drug-Resistant Tuberculosis (XDR-TB) is a recent challenge for tuberculosis control program. The absence of the functional drugs and high rate of the failure in treatment and mortality rate also high jeopardize for epidemiology. Its prevalence is unknown in India as there was no nationwide counselling. Globally, there were an estimated 55,100 new extensively drug resistant tuberculosis cases in the year of 2015 in 117 countries. However, only 30 cases extensively drug-resistant tuberculosis was reported. Drug susceptibility test (DST) is the cornerstone to diagnose extensively drug resistant tuberculosis, but the lack of laboratory facilities in the resource-limited endemic countries limits its uses. A few new drugs including bedaquiline and delamanid have the potential to improve the efficiency of extensively drug-resistant tuberculosis treatment, but those drugs are used in 39 countries only. The costs of extensively drug resistant tuberculosis treatment (XDR-TB) are several folds higher than then multi drug-resistant tuberculosis (MDR-TB).","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"6 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000349
C. Amado, M. Pérez
Hypovitaminosis D is highly prevalent worldwide [1]. Vitamin D importance is well known in bone diseases, but its role in infectious diseases has been recognised recently [2]. The main source of vitamin D is endogenous production in the skin under the influence of sun light. In the liver all vitamin D is hydroxylated to 25 hydroxyvitamin D (25OHD), which is the major circulating form of vitamin D, so serum levels of 25OHD are considered the best marker of nutritional vitamin D status. Under the control of feedback mechanisms 25OHD is hydroxylated in the kidney to the circulating hormone 1,25 (OH)2 D (calcitriol). Circulating calcitriol regulates calcium metabolism (“classical endocrine pathway of vitamin D”).
{"title":"Vitamin D Nutritional Status and Infectious Diseases","authors":"C. Amado, M. Pérez","doi":"10.4172/2332-0877.1000349","DOIUrl":"https://doi.org/10.4172/2332-0877.1000349","url":null,"abstract":"Hypovitaminosis D is highly prevalent worldwide [1]. Vitamin D importance is well known in bone diseases, but its role in infectious diseases has been recognised recently [2]. The main source of vitamin D is endogenous production in the skin under the influence of sun light. In the liver all vitamin D is hydroxylated to 25 hydroxyvitamin D (25OHD), which is the major circulating form of vitamin D, so serum levels of 25OHD are considered the best marker of nutritional vitamin D status. Under the control of feedback mechanisms 25OHD is hydroxylated in the kidney to the circulating hormone 1,25 (OH)2 D (calcitriol). Circulating calcitriol regulates calcium metabolism (“classical endocrine pathway of vitamin D”).","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"6 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000374
S. Na, D. Surov, I. Soloviev, A. Demko, Babkov Ov, G. V. Martynova, A. V. Sviatnenko, A. V. Osipov, B. Bezmozgin, Luk'ianiuk Pp
Over the last years, the number of publications devoted to the concept of enhanced recovery after surgery (ERAS) in emergency abdominal surgery application increases. The purpose of this study was a comparative analysis of the results of the ERAS-program application in surgical treatment of the patients with colorectal cancer complicated by large bowel obstruction (LBO). The study included 89 patients with obstructive colorectal carcinoma (OCRC), divided in the ERAS and control group (n=45 and n=44, respectively). During the treatment of the patients of the ERAS group in preoperative period, the following measures were taken: patient information, his psychological preparation, prevention of postoperative pain, nausea and vomiting, thromboembolic and infectious complications. Intraoperative measures included local anaesthesia of the skin in the line of laparotomy access, colon and small (under indications) intestines decompression, small intestine lavage, embryology oriented surgery and D3 lymphadenectomy, temporary installation of polyurethane catheter distal to the ligament of Treitz for early enteral nutrition, rectus sheath catheterization to carry out rectus sheath block of the anterior branches of the spinal nerves, control drainage installation into the small pelvis. In postoperative period, the early mobilization, urinary catheter and drainage removal after the patient transfer from intensive care unit were carried out. The following criteria were used as the criteria for comparative evaluation: pain syndrome intensity, need for analgesics, time of enteric deficiency arresting, postoperative complications and mortality, postoperative period duration, and patients' life quality after discharge from the hospital. It has been established that the proposed original ERAS program for this category of the patients is safe and effective due to improving the immediate results of surgical treatment.
{"title":"Application of the Program of Enhanced Recovery in Surgical Treatment of Patients with Colorectal Cancer Complicated by Acute Obstruction (Our Experience)","authors":"S. Na, D. Surov, I. Soloviev, A. Demko, Babkov Ov, G. V. Martynova, A. V. Sviatnenko, A. V. Osipov, B. Bezmozgin, Luk'ianiuk Pp","doi":"10.4172/2332-0877.1000374","DOIUrl":"https://doi.org/10.4172/2332-0877.1000374","url":null,"abstract":"Over the last years, the number of publications devoted to the concept of enhanced recovery after surgery (ERAS) in emergency abdominal surgery application increases. The purpose of this study was a comparative analysis of the results of the ERAS-program application in surgical treatment of the patients with colorectal cancer complicated by large bowel obstruction (LBO). The study included 89 patients with obstructive colorectal carcinoma (OCRC), divided in the ERAS and control group (n=45 and n=44, respectively). During the treatment of the patients of the ERAS group in preoperative period, the following measures were taken: patient information, his psychological preparation, prevention of postoperative pain, nausea and vomiting, thromboembolic and infectious complications. Intraoperative measures included local anaesthesia of the skin in the line of laparotomy access, colon and small (under indications) intestines decompression, small intestine lavage, embryology oriented surgery and D3 lymphadenectomy, temporary installation of polyurethane catheter distal to the ligament of Treitz for early enteral nutrition, rectus sheath catheterization to carry out rectus sheath block of the anterior branches of the spinal nerves, control drainage installation into the small pelvis. In postoperative period, the early mobilization, urinary catheter and drainage removal after the patient transfer from intensive care unit were carried out. The following criteria were used as the criteria for comparative evaluation: pain syndrome intensity, need for analgesics, time of enteric deficiency arresting, postoperative complications and mortality, postoperative period duration, and patients' life quality after discharge from the hospital. It has been established that the proposed original ERAS program for this category of the patients is safe and effective due to improving the immediate results of surgical treatment.","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2332-0877.1000376
Mohamed Ibrahim El Gharee, Mohamed Khate, A. Adel
{"title":"Autoinoculation Versus Intralesional Injection of Bleomycin in the Treatment of Multiple Recalcitrant Warts","authors":"Mohamed Ibrahim El Gharee, Mohamed Khate, A. Adel","doi":"10.4172/2332-0877.1000376","DOIUrl":"https://doi.org/10.4172/2332-0877.1000376","url":null,"abstract":"","PeriodicalId":73792,"journal":{"name":"Journal of infectious disease and therapy","volume":"06 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2332-0877.1000376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70295418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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