Pub Date : 2015-11-16DOI: 10.4172/2167-0897.1000203
Hong-yu Zhang, Y. Ling
Purpose of investigation: Observation of natural process of head to shoulder interval by waiting for at least one contraction (two-step method) after head delivered in normal birth. Method: From 1st to the end of mar. In 2015 at Haikou maternal and child hospital in China, women in vaginal delivery meet the criteria were recorded by video from head crown to shoulder and to body delivered. 92 cases normal vaginal birth with normal baby condition were recorded, video tapes were transfer to computer then replayed and observed. Interval of head crown to head delivery and head to shoulder delivery, babies' activities during birth were recorded from video at same time. Result: 1. The mean time of head to shoulder interval by waiting for a contraction is (71.043 ± 61.015) sec, mean+2Std. =193.073sec, 95% CI (15.65-229.15) sec. 2. 55.43 % (51/92) percent interval of head to shoulder were less than 60 sec, 39.1% (36/92) were over 60sec and less than 190 sec. 5.4 %( 5/92) over 190 sec. 3. 71.734% (66/92) shoulders were emerged from perineum, 15.217% (14/92) transversely, 13.04% (12/92) emerged from under pubic. 4. 22 % percent babies breathed before shoulder delivery, some after, some did not cry at all, but had normal heartbeat and breath Patten. Conclusion: 1. Head to shoulder delivery interval is longer than 60 sec by two step method of shoulder delivery. The majority shoulders emerged from perineum rather from under pubic. 96.73% (89/92) cases shoulders were delivered at the first contraction after head delivered, only 3.27% (3/92) cases had delivered by twice contractions. 2. Babies activities during delivery of shoulder included breath, making faces, sucking, bubble from noses and mouth, and the color of the face, all those signs indicated the normal live birth.
研究目的:观察正常分娩头产后等待至少一次宫缩(两步法)头肩间隔的自然过程。方法:2015年3月1日至3月底，在海口市妇幼医院对符合条件的阴道分娩妇女从头冠到肩再到全身进行录像记录。对92例正常阴道分娩的病例进行记录，并将录像传输到电脑中，进行回放观察。同时录像记录头冠到头和头肩分娩间隔，婴儿在分娩过程中的活动。结果:1。等待宫缩的头肩间隔时间平均为(71.043±61.015)秒，平均+2Std。=193.073sec, 95% CI (15.65-229.15) sec。55.43%(51/92)的人头肩间距小于60秒，39.1%(36/92)的人头肩间距大于60秒，小于190秒，5.4%(5/92)的人头肩间距大于190秒。71.734%(66/92)的肩部从会阴出露，15.217%(14/92)的肩部横向出露，13.04%(12/92)的肩部从耻骨下出露。4. 22%的婴儿在肩扛分娩前有呼吸，有些在肩扛分娩后，有些根本没有哭，但心跳和呼吸模式正常。结论:1。采用两步肩送法，头肩送间隔大于60秒。大部分肩部从会阴露出，而不是从耻骨下露出。96.73%(89/92)的产妇头产后第一次宫缩分娩肩，仅有3.27%(3/92)的产妇头产后两次宫缩分娩。2. 婴儿在肩部分娩时的活动包括呼吸、做鬼脸、吸吮、口鼻冒泡、面部颜色等，这些都是正常活产的迹象。
{"title":"Head to Shoulder Interval in 92 Cases Normal Birth with Good Baby Condition by Two Step Shoulder Delivery Method","authors":"Hong-yu Zhang, Y. Ling","doi":"10.4172/2167-0897.1000203","DOIUrl":"https://doi.org/10.4172/2167-0897.1000203","url":null,"abstract":"Purpose of investigation: Observation of natural process of head to shoulder interval by waiting for at least one contraction (two-step method) after head delivered in normal birth. \u0000Method: From 1st to the end of mar. In 2015 at Haikou maternal and child hospital in China, women in vaginal delivery meet the criteria were recorded by video from head crown to shoulder and to body delivered. 92 cases normal vaginal birth with normal baby condition were recorded, video tapes were transfer to computer then replayed and observed. Interval of head crown to head delivery and head to shoulder delivery, babies' activities during birth were recorded from video at same time. \u0000Result: 1. The mean time of head to shoulder interval by waiting for a contraction is (71.043 ± 61.015) sec, mean+2Std. =193.073sec, 95% CI (15.65-229.15) sec. 2. 55.43 % (51/92) percent interval of head to shoulder were less than 60 sec, 39.1% (36/92) were over 60sec and less than 190 sec. 5.4 %( 5/92) over 190 sec. 3. 71.734% (66/92) shoulders were emerged from perineum, 15.217% (14/92) transversely, 13.04% (12/92) emerged from under pubic. 4. 22 % percent babies breathed before shoulder delivery, some after, some did not cry at all, but had normal heartbeat and breath Patten. \u0000Conclusion: 1. Head to shoulder delivery interval is longer than 60 sec by two step method of shoulder delivery. The majority shoulders emerged from perineum rather from under pubic. 96.73% (89/92) cases shoulders were delivered at the first contraction after head delivered, only 3.27% (3/92) cases had delivered by twice contractions. 2. Babies activities during delivery of shoulder included breath, making faces, sucking, bubble from noses and mouth, and the color of the face, all those signs indicated the normal live birth.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"4 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-10DOI: 10.4172/2167-0897.1000202
Parvesh M Garg, Padma P Garg, C. Lal
Necrotizing Enterocolitis (NEC) is a common and devastating gastrointestinal emergency that primarily affects premature infants. The incidence of necrotizing enterocolitis is 6-10% among infants with birth weight less than 1500 grams. The mortality due to NEC has not improved significantly despite advances in neonatal care and better understanding of clinical and basic sciences. The pathogenesis of NEC is not well understood and several factors such as prematurity, abnormal colonization with pathogenic bacteria, feeding practices, blood transfusion and altered intestinal barrier function may be involved. The clinical presentation of NEC could be sudden and the treatment plan could vary with the stage and type of presentation. Further research is needed to better understand the pathophysiology of NEC and, biomarkers for prediction, prevention and treatment need to be developed. Further clinical trials are needed to determine prevention and treatment modalities for this devastating disease.
{"title":"Necrotizing Enterocolitis (NEC): A Devastating Disease of Prematurity.","authors":"Parvesh M Garg, Padma P Garg, C. Lal","doi":"10.4172/2167-0897.1000202","DOIUrl":"https://doi.org/10.4172/2167-0897.1000202","url":null,"abstract":"Necrotizing Enterocolitis (NEC) is a common and devastating gastrointestinal emergency that primarily affects premature infants. The incidence of necrotizing enterocolitis is 6-10% among infants with birth weight less than 1500 grams. The mortality due to NEC has not improved significantly despite advances in neonatal care and better understanding of clinical and basic sciences. The pathogenesis of NEC is not well understood and several factors such as prematurity, abnormal colonization with pathogenic bacteria, feeding practices, blood transfusion and altered intestinal barrier function may be involved. The clinical presentation of NEC could be sudden and the treatment plan could vary with the stage and type of presentation. Further research is needed to better understand the pathophysiology of NEC and, biomarkers for prediction, prevention and treatment need to be developed. Further clinical trials are needed to determine prevention and treatment modalities for this devastating disease.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"4 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-10-30DOI: 10.4172/2167-0897.1000201
Renoldner B, Hofer N, Resch B
Background: Early onset sepsis (EOS) of the newborn is a severe disease and associated with high morbidity and mortality. Aim of the study was to compare perinatal, short-term outcome and laboratory data of neonates with early-onset sepsis (EOS) either due to Group B Streptococci (GBS) or Escherichia coli (E. coli) infection. Methods: Retrospective cohort analysis of all neonates with culture proven GBS and E. coli EOS born between 1993 and 2011 and hospitalized at the NICU of the Medical University of Graz, Austria. Data were analyzed regarding perinatal, laboratory and short-term outcome data. Results: During the study period 100 neonates with EOS due to GBS and 11 neonates with E. coli infection were hospitalized at our NICU. Perinatal and short-term outcome data differed between GBS and E. coli infection regarding gestational age (median 38 vs. 32 weeks, p=.005), birth weight (median 3095 vs. 1836 grams, p=.031), presence of hypothermia (0 vs. 18%, p=.009), duration of mechanical ventilation (4 vs. 8 days, p=.019), duration of therapy with supplemental oxygen (9 vs. 2 days, p=.031), length of hospitalization (15 vs. 22 days, p=.039), presence of chorioamnionitis (17 vs. 46%, p=.041) and maternal fever (2 vs. 18%, p=.049). Mortality rates did not differ significantly (6 vs. 18%, p=.180). Laboratory data regarding white blood cell count, IT-ratio, and CRP value were not different between groups within the first 72 hours of life. There was a significant decrease of GBS sepsis during the study period (p=0,014). Conclusion: Main differences between GBS and E. coli infections were due to higher rates of preterm birth in the E. coli group, clinical and laboratory characteristics only differed marginally.
{"title":"Early-Onset Neonatal Sepsis: Group B Streptococcal Compared to E. coli Disease","authors":"Renoldner B, Hofer N, Resch B","doi":"10.4172/2167-0897.1000201","DOIUrl":"https://doi.org/10.4172/2167-0897.1000201","url":null,"abstract":"Background: Early onset sepsis (EOS) of the newborn is a severe disease and associated with high morbidity and mortality. Aim of the study was to compare perinatal, short-term outcome and laboratory data of neonates with early-onset sepsis (EOS) either due to Group B Streptococci (GBS) or Escherichia coli (E. coli) infection. \u0000Methods: Retrospective cohort analysis of all neonates with culture proven GBS and E. coli EOS born between 1993 and 2011 and hospitalized at the NICU of the Medical University of Graz, Austria. Data were analyzed regarding perinatal, laboratory and short-term outcome data. \u0000Results: During the study period 100 neonates with EOS due to GBS and 11 neonates with E. coli infection were hospitalized at our NICU. Perinatal and short-term outcome data differed between GBS and E. coli infection regarding gestational age (median 38 vs. 32 weeks, p=.005), birth weight (median 3095 vs. 1836 grams, p=.031), presence of hypothermia (0 vs. 18%, p=.009), duration of mechanical ventilation (4 vs. 8 days, p=.019), duration of therapy with supplemental oxygen (9 vs. 2 days, p=.031), length of hospitalization (15 vs. 22 days, p=.039), presence of chorioamnionitis (17 vs. 46%, p=.041) and maternal fever (2 vs. 18%, p=.049). Mortality rates did not differ significantly (6 vs. 18%, p=.180). Laboratory data regarding white blood cell count, IT-ratio, and CRP value were not different between groups within the first 72 hours of life. There was a significant decrease of GBS sepsis during the study period (p=0,014). Conclusion: Main differences between GBS and E. coli infections were due to higher rates of preterm birth in the E. coli group, clinical and laboratory characteristics only differed marginally.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"4 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-30DOI: 10.4172/2167-0897.1000200
Takafumi Kondō, Shohei Honda, Masashi Minato, Sorahiko Fujisawa, H. Miyagi, Kazutoshi Cho, H. Minakami, A. Taketomi
A wide spectrum of variations can occur in esophageal atresia because of the complexity of tracheoesophageal development. We herein described a 0-day-old boy with type IIIb6 esophageal atresia. Esophagography revealed a long overlapping upper pouch that was similar to esophageal stenosis. Gastrostomy is useful for the therapeutic diagnosis of such a case.
{"title":"A Preoperative Diagnostic Challenge of a Long Overlapping Upper Pouch with Distal Tracheoesophageal Fistula","authors":"Takafumi Kondō, Shohei Honda, Masashi Minato, Sorahiko Fujisawa, H. Miyagi, Kazutoshi Cho, H. Minakami, A. Taketomi","doi":"10.4172/2167-0897.1000200","DOIUrl":"https://doi.org/10.4172/2167-0897.1000200","url":null,"abstract":"A wide spectrum of variations can occur in esophageal atresia because of the complexity of tracheoesophageal development. We herein described a 0-day-old boy with type IIIb6 esophageal atresia. Esophagography revealed a long overlapping upper pouch that was similar to esophageal stenosis. Gastrostomy is useful for the therapeutic diagnosis of such a case.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"4 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-30DOI: 10.4172/2167-0897.1000199
Asma Dorbani, Abdelmadjid Bairi, M. Ouakid, A. Tahraoui
For most animals smell is the primal sense. One they rely on to identify food, predators and mates. Indeed, for many organisms, odours arc their most efficient means of communicating with others and interpreting their surroundings. Innate behaviour in response to smell is essential to these organisms' survival and most likely result s from nonconscious perception of odours. This article is part of a research program dealing with the consequences of bilateral nasal obstruction (NO) during the postnatal development of mammals. Its aim was to test if the absence of nasal respiration and the related transition to chronic oral breathing could perturb the development of the individual. Therefore, a NO was induced in 8-day old rats (D8) and its effects were investigated 24 h after the treatment (D9), at the end of the obstruction period (D15) and six days after the reopening of the nostrils (D21). The results showed that NO affect some hormonal functions, these modifications were pronounced at D9, D15 and D21. Lastly, NO was associated with an atrophy of the brain at D15, it was maintained until D21. In rats, nasal obstruction can thus be considered like a multifactorial stressful situation. Its effects lasted until adulthood.
对大多数动物来说，嗅觉是最原始的感觉。它们依靠它来识别食物、捕食者和配偶。事实上，对于许多生物来说，气味是它们与其他生物交流和理解周围环境的最有效手段。对气味作出反应的先天行为对这些生物的生存至关重要，而且很可能是无意识地感知气味的结果。这篇文章是一个研究项目的一部分，涉及哺乳动物出生后发育过程中双侧鼻塞(NO)的后果。其目的是测试鼻呼吸的缺失以及相关的向慢性口腔呼吸的过渡是否会干扰个体的发育。因此，在8日龄大鼠(D8)中诱导一氧化氮，并在治疗后24 h (D9)、梗阻期结束时(D15)和鼻孔重开后6 d (D21)观察其作用。结果表明，NO影响了部分激素功能，这种影响在D9、D15和D21时较为明显。最后，NO与D15时脑萎缩有关，这种情况一直持续到D21。在大鼠中，鼻塞可以被认为是一个多因素的压力情况。它的影响一直持续到成年。
{"title":"Endocrine and Immunological Alterations under Early Nasal Obstruction in Rats Wistar","authors":"Asma Dorbani, Abdelmadjid Bairi, M. Ouakid, A. Tahraoui","doi":"10.4172/2167-0897.1000199","DOIUrl":"https://doi.org/10.4172/2167-0897.1000199","url":null,"abstract":"For most animals smell is the primal sense. One they rely on to identify food, predators and mates. Indeed, for many organisms, odours arc their most efficient means of communicating with others and interpreting their surroundings. Innate behaviour in response to smell is essential to these organisms' survival and most likely result s from nonconscious perception of odours. This article is part of a research program dealing with the consequences of bilateral nasal obstruction (NO) during the postnatal development of mammals. Its aim was to test if the absence of nasal respiration and the related transition to chronic oral breathing could perturb the development of the individual. Therefore, a NO was induced in 8-day old rats (D8) and its effects were investigated 24 h after the treatment (D9), at the end of the obstruction period (D15) and six days after the reopening of the nostrils (D21). The results showed that NO affect some hormonal functions, these modifications were pronounced at D9, D15 and D21. Lastly, NO was associated with an atrophy of the brain at D15, it was maintained until D21. In rats, nasal obstruction can thus be considered like a multifactorial stressful situation. Its effects lasted until adulthood.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"04 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-25DOI: 10.4172/2167-0897.1000198
Keisuke Kobata, M. Nabetani, Nanae Yutaka, Hiroyuki, Sanno
We experienced six cases who could undergo therapeutic hypothermia (TH) therapy combined with inhaled nitric oxide (iNO) therapy and one persistent pulmonary hypertension (PPHN) case who could undergo and stop TH during 2002-2014. We experienced no complication in these six cases. We have compared perinatal factors, MRI findings around one-year-old, Gross Motor Function Classification System (GMFCS) and developmental quotient around one and a half year old between 6 cases who underwent TH therapy completely combined with iNO therapy (TH+iNO group) and 38 cases who underwent only TH therapy (TH group). There are no significant differences of perinatal factors, MRI findings, GMFCS, and developmental quotient between (TH+iNO group) and (TH group). These results showed TH could be performed safely for HIE cases with PPHN combined with iNO therapy maintaining the stable condition of respiration and circulation. We need to investigate more PPHN cases with iNO therapy to clarify criteria which cases could be performed TH therapy safely.
{"title":"Experiences of Therapeutic Hypothermia Therapy on Six Cases with Persistent: Pulmonary Hypertension and Moderate to Severe Hypoxic Ischemic Encephalopathy using Inhaled Nitric Oxide Therapy","authors":"Keisuke Kobata, M. Nabetani, Nanae Yutaka, Hiroyuki, Sanno","doi":"10.4172/2167-0897.1000198","DOIUrl":"https://doi.org/10.4172/2167-0897.1000198","url":null,"abstract":"We experienced six cases who could undergo therapeutic hypothermia (TH) therapy combined with inhaled nitric oxide (iNO) therapy and one persistent pulmonary hypertension (PPHN) case who could undergo and stop TH during 2002-2014. We experienced no complication in these six cases. We have compared perinatal factors, MRI findings around one-year-old, Gross Motor Function Classification System (GMFCS) and developmental quotient around one and a half year old between 6 cases who underwent TH therapy completely combined with iNO therapy (TH+iNO group) and 38 cases who underwent only TH therapy (TH group). There are no significant differences of perinatal factors, MRI findings, GMFCS, and developmental quotient between (TH+iNO group) and (TH group). These results showed TH could be performed safely for HIE cases with PPHN combined with iNO therapy maintaining the stable condition of respiration and circulation. We need to investigate more PPHN cases with iNO therapy to clarify criteria which cases could be performed TH therapy safely.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2015-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-24DOI: 10.4172/2167-0897.1000197
Tripaldi Clelia, Baldoni Irene, P. Lucio
Hair collar sign is a rare malformation of the scalp, often associated with impairment of the central nervous system such as encephaloceles, meningoceles, and heterotopic brain tissue. We describe the cases of two male neonates, with maternal history positive for viral infections in pregnancy and no associated malformations of the nervous system, but coexistence of cutaneous plan nevi.
{"title":"Hair Collar Sign and Viral Infection in Pregnancy: Two Clinical Cases","authors":"Tripaldi Clelia, Baldoni Irene, P. Lucio","doi":"10.4172/2167-0897.1000197","DOIUrl":"https://doi.org/10.4172/2167-0897.1000197","url":null,"abstract":"Hair collar sign is a rare malformation of the scalp, often associated with impairment of the central nervous system such as encephaloceles, meningoceles, and heterotopic brain tissue. We describe the cases of two male neonates, with maternal history positive for viral infections in pregnancy and no associated malformations of the nervous system, but coexistence of cutaneous plan nevi.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"14 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2015-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-12DOI: 10.4172/2167-0897.1000196
A. Bülbül, M. Dursun, Yıldız Yıldırmak, B. Akyol, Umut ZübarioÄlu, E. Ünal, Lida Bülbül, Selcen YaroÄlu KazancÄ, S. Uslu
Congenital leukemia is a very rare malignancy of childhood with a poor prognosis. The incidence is nearly 1 in 5 million live births. The majority of cases are acute myeloblastic leukemia with trisomy. Clinical manifestations are usually leukocytosis, petechia, ecchymosis, cutaneous nodules, hepatosplenomegaly and central nervous system symptoms. 23-days old girl was presented with complaints of maculopapular dermatitis and hepatosplenomegaly diagnosed as AML M1. During the follow-up period massive pericardial effusion was detected. This case is presented due to emphasize the rare association of pericardial effusion with congenital leukemia without trisomy and spontaneous remission of leukemia that was occasionally appear in the literature.
{"title":"Spontaneous Remission in Congenital Leukemia AML-M1 with Pericardial Effusion","authors":"A. Bülbül, M. Dursun, Yıldız Yıldırmak, B. Akyol, Umut ZübarioÄlu, E. Ünal, Lida Bülbül, Selcen YaroÄlu KazancÄ, S. Uslu","doi":"10.4172/2167-0897.1000196","DOIUrl":"https://doi.org/10.4172/2167-0897.1000196","url":null,"abstract":"Congenital leukemia is a very rare malignancy of childhood with a poor prognosis. The incidence is nearly 1 in 5 million live births. The majority of cases are acute myeloblastic leukemia with trisomy. Clinical manifestations are usually leukocytosis, petechia, ecchymosis, cutaneous nodules, hepatosplenomegaly and central nervous system symptoms. 23-days old girl was presented with complaints of maculopapular dermatitis and hepatosplenomegaly diagnosed as AML M1. During the follow-up period massive pericardial effusion was detected. This case is presented due to emphasize the rare association of pericardial effusion with congenital leukemia without trisomy and spontaneous remission of leukemia that was occasionally appear in the literature.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2015-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-11DOI: 10.4172/2167-0897.1000193
N. Vargas, M. E. Ceccon, Mario CiceroFalcao, W. B. Carvalho
Abstract Objective The aim of this study were, using only the score clinic of Sarnat and Sarnat, the blood markers of asphyxia that are routinely used in all hospitals of our country (Brazil) and the ultrasonography imaging method performed with 24 and 72 hours and 28 days of life, verify if these are sufficient to detect the neurological evolution of the patient. Methods The study was conducted with a prospective cohort of term newborns that suffering perinatal asphyxia by Buonocore criteria (2002). These criteria identify the level of the pH in cord blood that was collected of all newborns and also the blood markers: glutamic oxaloacetic transaminase, glutamic pyruvate transaminase, lactate dehydrogenase and creatine kinase (CKMB).These testes were collected at birth, with 24, 48 and 72 hours of life. The score clinical of Sarnat and Sarnat was performed with 24 hours, 48 hours and 72 hours of life and the ultrasound skull with 24, 48, 72 hours of life and in the end of neonatal period with 28 days of life. The period of study was one year. Results In the study´s period 2989 babies were born. The Buonocore criteria were found in 28 newborn showing a frequency of 1% of perinatal asphyxia. The marker of asphyxia were between the normal value of reference and only de iso-enzyme CKMB was a good marker, com value more than 5,10 ng/mL. The brain ultrasonography was altered with 72 hours of life, but one newborn presented alterations only with 28 days of life. The clinical examination using the clinical score of Sarnat and Sarnat demonstrated that 21,42% presented hypoxic-ischemic encephalopathy. In the ROC curve we observed sensitivity of 85,7%, specificity of 85,7% and accuracy of 85,7% correlated the value of CKMB and the brain ultrasonography of 72 hours of life. Conclusions Perinatal asphyxia may be diagnosed in any hospital if the neonatologist or the neurologist apply the easy score clinical of Sarnat and Sarnat, the iso-enzime CKMB and the serial ultrasonography. In this study the worse alteration was with 72 hours of life, however we must be careful because in one neonate the alteration was present only with 28 days of life.
{"title":"Prognostic Markers of Neonatal Outcomes in Full Term Neonates Suffering from Perinatal Asphyxia","authors":"N. Vargas, M. E. Ceccon, Mario CiceroFalcao, W. B. Carvalho","doi":"10.4172/2167-0897.1000193","DOIUrl":"https://doi.org/10.4172/2167-0897.1000193","url":null,"abstract":"Abstract \u0000Objective The aim of this study were, using only the score clinic of Sarnat and Sarnat, the blood markers of asphyxia that are routinely used in all hospitals of our country (Brazil) and the ultrasonography imaging method performed with 24 and 72 hours and 28 days of life, verify if these are sufficient to detect the neurological evolution of the patient. \u0000Methods \u0000The study was conducted with a prospective cohort of term newborns that suffering perinatal asphyxia by Buonocore criteria (2002). These criteria identify the level of the pH in cord blood that was collected of all newborns and also the blood markers: glutamic oxaloacetic transaminase, glutamic pyruvate transaminase, lactate dehydrogenase and creatine kinase (CKMB).These testes were collected at birth, with 24, 48 and 72 hours of life. The score clinical of Sarnat and Sarnat was performed with 24 hours, 48 hours and 72 hours of life and the ultrasound skull with 24, 48, 72 hours of life and in the end of neonatal period with 28 days of life. The period of study was one year. \u0000Results \u0000In the study´s period 2989 babies were born. The Buonocore criteria were found in 28 newborn showing a frequency of 1% of perinatal asphyxia. The marker of asphyxia were between the normal value of reference and only de iso-enzyme CKMB was a good marker, com value more than 5,10 ng/mL. The brain ultrasonography was altered with 72 hours of life, but one newborn presented alterations only with 28 days of life. The clinical examination using the clinical score of Sarnat and Sarnat demonstrated that 21,42% presented hypoxic-ischemic encephalopathy. In the ROC curve we observed sensitivity of 85,7%, specificity of 85,7% and accuracy of 85,7% correlated the value of CKMB and the brain ultrasonography of 72 hours of life. Conclusions \u0000Perinatal asphyxia may be diagnosed in any hospital if the neonatologist or the neurologist apply the easy score clinical of Sarnat and Sarnat, the iso-enzime CKMB and the serial ultrasonography. In this study the worse alteration was with 72 hours of life, however we must be careful because in one neonate the alteration was present only with 28 days of life.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"4 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-11DOI: 10.4172/2167-0897.1000192
M. S. Raban, S. J. Muller, M. Harrison
Congenital syngnathia is a rare anomaly characterised by the presence of soft tissue (synechia) or bony adhesions (synostosis) between the maxilla and mandible. A wide spectrum and range of severity have been documented in case reports. Primarily it manifests in the inability to open the mouth; impacting on mandibular growth, nutrition, speech and management of the airway. The bony adhesions can be classified as partial or complete, as well as syndromic and non-syndromic. The aetiology of congenital syngnathia remains unknown. We describe a growth restricted, premature infant diagnosed postnatal with multiple congenital anomalies including syngnathia, craniosynostosis, ventriculomegaly, microcephaly, bilateral cataracts, facial dysmorphism, small kidneys, hypoplastic prepuce of the genitalia and bilateral syndactyly of toes 2, 3 and 4. The rare finding of syngnathia with the associated findings in a premature male infant weighing 1065 g at 31 weeks of corrected gestational age is the first to be reported.
{"title":"An Unusual Case of Congenital Syngnathia","authors":"M. S. Raban, S. J. Muller, M. Harrison","doi":"10.4172/2167-0897.1000192","DOIUrl":"https://doi.org/10.4172/2167-0897.1000192","url":null,"abstract":"Congenital syngnathia is a rare anomaly characterised by the presence of soft tissue (synechia) or bony adhesions (synostosis) between the maxilla and mandible. A wide spectrum and range of severity have been documented in case reports. Primarily it manifests in the inability to open the mouth; impacting on mandibular growth, nutrition, speech and management of the airway. The bony adhesions can be classified as partial or complete, as well as syndromic and non-syndromic. The aetiology of congenital syngnathia remains unknown. We describe a growth restricted, premature infant diagnosed postnatal with multiple congenital anomalies including syngnathia, craniosynostosis, ventriculomegaly, microcephaly, bilateral cataracts, facial dysmorphism, small kidneys, hypoplastic prepuce of the genitalia and bilateral syndactyly of toes 2, 3 and 4. The rare finding of syngnathia with the associated findings in a premature male infant weighing 1065 g at 31 weeks of corrected gestational age is the first to be reported.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2015-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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