Pub Date : 2024-01-01Epub Date: 2024-01-12DOI: 10.26502/jppch.74050172
Martin Varea Romo, Kishor Acharya, Nathan R Shelman, Phillip Minar, Lee A Denson, Samir Softic
Here, we describe a 7-year-old girl who was diagnosed with an early-onset Crohn's disease in the setting of COVID-19 illness. Her disease process responded poorly to standard infliximab dosing, necessitating repeat hospitalizations and red blood cell transfusions. Remission was subsequently induced using a personalized infliximab pharmacokinetic profile based on therapeutic drug monitoring. While the initial data does not support a link, several case reports suggest an association between COVID-19 illness and de-novo development of IBD, especially in young female patients. We report, to our knowledge, the youngest patient who developed early-onset Crohn's disease in the setting of concomitant SARS-CoV-2 infection.
{"title":"De Novo Crohn's Disease Diagnosed in the Setting of Acute SARS-Cov-2 Infection Requiring Escalation of Infliximab Therapy Guided by Personalized Pharmacokinetics.","authors":"Martin Varea Romo, Kishor Acharya, Nathan R Shelman, Phillip Minar, Lee A Denson, Samir Softic","doi":"10.26502/jppch.74050172","DOIUrl":"https://doi.org/10.26502/jppch.74050172","url":null,"abstract":"<p><p>Here, we describe a 7-year-old girl who was diagnosed with an early-onset Crohn's disease in the setting of COVID-19 illness. Her disease process responded poorly to standard infliximab dosing, necessitating repeat hospitalizations and red blood cell transfusions. Remission was subsequently induced using a personalized infliximab pharmacokinetic profile based on therapeutic drug monitoring. While the initial data does not support a link, several case reports suggest an association between COVID-19 illness and de-novo development of IBD, especially in young female patients. We report, to our knowledge, the youngest patient who developed early-onset Crohn's disease in the setting of concomitant SARS-CoV-2 infection.</p>","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"8 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-16DOI: 10.1101/2023.07.13.23292421
Dinesh P Asati, K. Baheti, Maninder Kaur, S. Patra, Kritika Singhal Singhal
Background: A sudden surge of occupation-associated dermatoses among the healthcare workers (HCWs) serving COVID-19 patients have been witnessed recently due to increased usage of PPE (PPE) kits and increased frequency of hygiene practices, with a significant impact on their quality of life and compromised efficacy at work. Hence, this study was conducted to measure the prevalence of occupational dermatoses among HCWs serving Covid-19 patients using PPE kits and hygiene practices and their impact on quality of life. Methods: HCWs of all cadres were screened for occupation-associated dermatoses. Cases with occupational dermatosis were evaluated further regarding the use of a PPE kit, and DLQI was calculated. Results: 19% of HCWs had dermatoses associated with PPE and hygiene practices. Hands were most affected, followed by the face, nasal bridge, and facial skin in contact with goggles. 48% had Mathias score >/= 4. Most cases had reported some impact on their quality of life. A significant association could be established between frequency of hand washing >/= 10 times/day with hand dermatitis (p=0.000). Conclusion: The use of PPE has significantly raised cases of occupational dermatosis among HCWs. Repeated hand washing and hand sanitizer use has increased the incidence of hand dermatitis.
{"title":"Occupational dermatoses in health care personnel using PPE during the COVID pandemic.","authors":"Dinesh P Asati, K. Baheti, Maninder Kaur, S. Patra, Kritika Singhal Singhal","doi":"10.1101/2023.07.13.23292421","DOIUrl":"https://doi.org/10.1101/2023.07.13.23292421","url":null,"abstract":"Background: A sudden surge of occupation-associated dermatoses among the healthcare workers (HCWs) serving COVID-19 patients have been witnessed recently due to increased usage of PPE (PPE) kits and increased frequency of hygiene practices, with a significant impact on their quality of life and compromised efficacy at work. Hence, this study was conducted to measure the prevalence of occupational dermatoses among HCWs serving Covid-19 patients using PPE kits and hygiene practices and their impact on quality of life. Methods: HCWs of all cadres were screened for occupation-associated dermatoses. Cases with occupational dermatosis were evaluated further regarding the use of a PPE kit, and DLQI was calculated. Results: 19% of HCWs had dermatoses associated with PPE and hygiene practices. Hands were most affected, followed by the face, nasal bridge, and facial skin in contact with goggles. 48% had Mathias score >/= 4. Most cases had reported some impact on their quality of life. A significant association could be established between frequency of hand washing >/= 10 times/day with hand dermatitis (p=0.000). Conclusion: The use of PPE has significantly raised cases of occupational dermatosis among HCWs. Repeated hand washing and hand sanitizer use has increased the incidence of hand dermatitis.","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42365215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miriam Weijers, Jonne Van der Zwet, N. Boumans, F. Feron, Caroline H.G. Bastiaenen
Feasibility
可行性
{"title":"A Digital Dashboard for Visual Representation of Child Health Information: Results of A Mixed Methods Study on Usability and Feasibility of A New CHILD-Profile","authors":"Miriam Weijers, Jonne Van der Zwet, N. Boumans, F. Feron, Caroline H.G. Bastiaenen","doi":"10.26502/jppch.74050142","DOIUrl":"https://doi.org/10.26502/jppch.74050142","url":null,"abstract":"Feasibility","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69350508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Exudative pleural effusion in children is mainly caused by bacterial infections. Leukemia rarely presents as pleural effusion as the first manifestation of the disease process. Bilateral malignant pleural effusion as an initial manifestation that leads to the diagnosis of an underlying acute lymphoblastic leukemia is a rare event. Most commonly pleural effusion is seen as complication in solid tumors such as the lung, lymphomas, carcinomas of the breast and gastrointestinal tract.
{"title":"Bilateral Malignant Pleural Effusion as an Initial Manifestation of Acute Lymphoblastic Leukemia: A Rare Case Report","authors":"Gajjar Jay Daxay, Vyakhya ., Ajeta Vijaykumar Gupta, Bhagwan Sahai Sharma, Susheel kumar saini, Madhur Sarthalia, Ajay kumar saini","doi":"10.26502/jppch.74050148","DOIUrl":"https://doi.org/10.26502/jppch.74050148","url":null,"abstract":"Exudative pleural effusion in children is mainly caused by bacterial infections. Leukemia rarely presents as pleural effusion as the first manifestation of the disease process. Bilateral malignant pleural effusion as an initial manifestation that leads to the diagnosis of an underlying acute lymphoblastic leukemia is a rare event. Most commonly pleural effusion is seen as complication in solid tumors such as the lung, lymphomas, carcinomas of the breast and gastrointestinal tract.","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69350612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ariel Ben, Abu Arisha Rana, Bechor Ariel Tal, Yana Moshe, Leibzon Maor, Ben-Acon Michael, Sharon Nechama
Background: Androgens and testosterone can induce erythrocytosis in several mechanisms. Adolescent males often present to primary clinics with an elevated Red Blood Cell values without Hemoglobin abnormalities. We investigated the correlation between serum testosterone levels and red blood cell values. Methods: 91 adolescents who were referred to the Emergency department were included in the trial, for which a complete blood count and serum testosterone were obtained, along with assessing Tanner score. Patients were divided into two groups with high and low red blood cell count. Mann -Whitney U test was performed to compare Serum testosterone level and Tanner score between the groups. Pearson’s correlation coefficient was calculated to determine the correlation between red blood cell count and Testosterone levels. Results: Testosterone levels was higher in the erythrocytosis group 14.05 (SD 5.53) vs non erythrocytosis group 11.94 (SD 7.38) although it did not meet statistical significance (p-value = 0.168). There is a weak positive correlation (Pearson’s R = 0.146) between testosterone and erythrocyte levels. Conclusion: In healthy adolescent males, whose serum testosterone levels are within normal range we observed erythrocytosis in 22% of patients. Testosterone levels was positively correlated with
{"title":"Correlation between Serum Testosterone Level and Erythrocytosis in Adolescent Males- A Cross-Sectional Study","authors":"Ariel Ben, Abu Arisha Rana, Bechor Ariel Tal, Yana Moshe, Leibzon Maor, Ben-Acon Michael, Sharon Nechama","doi":"10.26502/jppch.74050137","DOIUrl":"https://doi.org/10.26502/jppch.74050137","url":null,"abstract":"Background: Androgens and testosterone can induce erythrocytosis in several mechanisms. Adolescent males often present to primary clinics with an elevated Red Blood Cell values without Hemoglobin abnormalities. We investigated the correlation between serum testosterone levels and red blood cell values. Methods: 91 adolescents who were referred to the Emergency department were included in the trial, for which a complete blood count and serum testosterone were obtained, along with assessing Tanner score. Patients were divided into two groups with high and low red blood cell count. Mann -Whitney U test was performed to compare Serum testosterone level and Tanner score between the groups. Pearson’s correlation coefficient was calculated to determine the correlation between red blood cell count and Testosterone levels. Results: Testosterone levels was higher in the erythrocytosis group 14.05 (SD 5.53) vs non erythrocytosis group 11.94 (SD 7.38) although it did not meet statistical significance (p-value = 0.168). There is a weak positive correlation (Pearson’s R = 0.146) between testosterone and erythrocyte levels. Conclusion: In healthy adolescent males, whose serum testosterone levels are within normal range we observed erythrocytosis in 22% of patients. Testosterone levels was positively correlated with","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69350451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jianna J. Lin, Jeremy Zhang, Lucille Anzia, Laura L. Hayes
CT scans are an indispensable tool for evaluating head injuries and neurological symptoms, yet they are the leading contributor to medical radiation exposure in the United States. High levels of such exposure pose significant health risks for children, whose developing bodies are less resilient to radiation injury. Here we review mean radiation dose (Total Exam DLP) and CTDlvol from head CT scans of 149 cases to assess for factors thought to be potential contributors to excess radiation exposure. Such factors included scan indication (trauma, shunts, other head complaints), number of repeat scans, and the type of facility the scan was performed (adult vs. pediatric). Analyses revealed that among scans performed to evaluate head trauma or routine indications (e.g. headache, vomiting focal neurologic deficits), the mean radiation dose a administered was significantly higher in adults hospitals when compared to pediatric hospitals. Findings highlight the importance of ensuring appropriate dose settings to increase the safety of CT scans for children. Based on our results identifying suboptimal scanner settings as a fundamental cause of excess radiation exposure, the evidence supports adjusting protocols to appropriate settings as the most effective method of reducing excess radiation exposure to children receiving head CT scans.
{"title":"Failure to Adjust CT Scanners to Pediatric Settings is a Major Cause of Unnecessary Radiation Exposure to Children","authors":"Jianna J. Lin, Jeremy Zhang, Lucille Anzia, Laura L. Hayes","doi":"10.26502/jppch.74050166","DOIUrl":"https://doi.org/10.26502/jppch.74050166","url":null,"abstract":"CT scans are an indispensable tool for evaluating head injuries and neurological symptoms, yet they are the leading contributor to medical radiation exposure in the United States. High levels of such exposure pose significant health risks for children, whose developing bodies are less resilient to radiation injury. Here we review mean radiation dose (Total Exam DLP) and CTDlvol from head CT scans of 149 cases to assess for factors thought to be potential contributors to excess radiation exposure. Such factors included scan indication (trauma, shunts, other head complaints), number of repeat scans, and the type of facility the scan was performed (adult vs. pediatric). Analyses revealed that among scans performed to evaluate head trauma or routine indications (e.g. headache, vomiting focal neurologic deficits), the mean radiation dose a administered was significantly higher in adults hospitals when compared to pediatric hospitals. Findings highlight the importance of ensuring appropriate dose settings to increase the safety of CT scans for children. Based on our results identifying suboptimal scanner settings as a fundamental cause of excess radiation exposure, the evidence supports adjusting protocols to appropriate settings as the most effective method of reducing excess radiation exposure to children receiving head CT scans.","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135060165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacques Balekelayi wa Balekelayi, Valérie Bolingo Bola, Stéphanie Mikalo Mbambi, Joseph Mabiala Bodi, Victoire Audray Bikoumou
Prognostic
{"title":"Prognostic of Sepsis in a Congolese Pediatric Emergency Service Using PSOFA Score: A Prospective Study","authors":"Jacques Balekelayi wa Balekelayi, Valérie Bolingo Bola, Stéphanie Mikalo Mbambi, Joseph Mabiala Bodi, Victoire Audray Bikoumou","doi":"10.26502/jppch.74050162","DOIUrl":"https://doi.org/10.26502/jppch.74050162","url":null,"abstract":"Prognostic","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135445107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01Epub Date: 2023-11-29DOI: 10.26502/jppch.74050168
Monika Piatek, Elie G Abu Jawdeh, Peter Giannone, Brandon Miller, Aric Schadler, Mina Hanna
Background: The aim of this study was to better understand the relationship between intraventricular hemorrhage and the risk of development of early lung disease in extremely low birth weight infants. We hypothesize that infants with severe intraventricular hemorrhage have higher respiratory severity scores than infants with mild/no intraventricular hemorrhage within the first 7 days of life.
Methods: This was a single center retrospective study conducted on subjects born between 01/01/2018 and 06/30/2021 at the University of Kentucky Children's Hospital NICU. We enrolled preterm infants with gestational age of less than 30 weeks and birth weight of less than 1000 grams who were placed on mechanical ventilation on admission.
Results: We found a clinically significant increasing trend of respiratory severity scores within the first week of life in the group of infants with severe intraventricular hemorrhage.
Conclusion: This study is first to show that severe intraventricular hemorrhage is associated with higher respiratory severity scores predicting early lung injury in the extremely low birth weight infants placed on a mechanical ventilator within the first 7 days of life.
{"title":"Severe Intraventricular Hemorrhage is Associated with Lung Injury in Preterm Infants on Mechanical Ventilation.","authors":"Monika Piatek, Elie G Abu Jawdeh, Peter Giannone, Brandon Miller, Aric Schadler, Mina Hanna","doi":"10.26502/jppch.74050168","DOIUrl":"10.26502/jppch.74050168","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to better understand the relationship between intraventricular hemorrhage and the risk of development of early lung disease in extremely low birth weight infants. We hypothesize that infants with severe intraventricular hemorrhage have higher respiratory severity scores than infants with mild/no intraventricular hemorrhage within the first 7 days of life.</p><p><strong>Methods: </strong>This was a single center retrospective study conducted on subjects born between 01/01/2018 and 06/30/2021 at the University of Kentucky Children's Hospital NICU. We enrolled preterm infants with gestational age of less than 30 weeks and birth weight of less than 1000 grams who were placed on mechanical ventilation on admission.</p><p><strong>Results: </strong>We found a clinically significant increasing trend of respiratory severity scores within the first week of life in the group of infants with severe intraventricular hemorrhage.</p><p><strong>Conclusion: </strong>This study is first to show that severe intraventricular hemorrhage is associated with higher respiratory severity scores predicting early lung injury in the extremely low birth weight infants placed on a mechanical ventilator within the first 7 days of life.</p>","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"7 4","pages":"229-234"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10785697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hepatitis A virus infections are mostly asymptomatic or mildly symptomatic in pediatric population. Generally this disease has a benign course and resolves spontaneously. However, intrahepatic and extrahepatic manifestations can complicate typical course of acute hepatitis A in children. Pleural effusion, acalculous cholecystitis and ascites are extremely rare extrahepatic complications. Pleural effusion or ascites does not change the prognosis or require any invasive treatment usually. We report a case of 8 years old boy presented with both pleural effusion and gross ascites accompanying hepatitis A infection. Diagnosis was done using serological testing and imaging studies. He was treated with supportive management only with full recovery after 4 weeks.
{"title":"A Rare Case of Childhood Hepatitis A Infection with Bilateral Pleural Effusion Acalculous Cholecystitis and Massive Ascites","authors":"Ranjum, Naina Nanda, Nitya Sehgal, Susheel kumar saini, Vinay Gahlot, Keerthana Anigani, Tushar Jagat, Ajay kumar saini, S. Kumari","doi":"10.26502/jppch.74050140","DOIUrl":"https://doi.org/10.26502/jppch.74050140","url":null,"abstract":"Hepatitis A virus infections are mostly asymptomatic or mildly symptomatic in pediatric population. Generally this disease has a benign course and resolves spontaneously. However, intrahepatic and extrahepatic manifestations can complicate typical course of acute hepatitis A in children. Pleural effusion, acalculous cholecystitis and ascites are extremely rare extrahepatic complications. Pleural effusion or ascites does not change the prognosis or require any invasive treatment usually. We report a case of 8 years old boy presented with both pleural effusion and gross ascites accompanying hepatitis A infection. Diagnosis was done using serological testing and imaging studies. He was treated with supportive management only with full recovery after 4 weeks.","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69350501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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