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Dramatic Response of Multi-System Inflammatory Involvement (Mis-N) in Neonates Treated with IvIg and Methylprednisolone IvIg和甲基强的松龙治疗新生儿多系统炎症累及(misn)的显著反应
Pub Date : 2022-01-01 DOI: 10.26502/jppch.74050127
Ashutosh Singh Rathore, Harshita Jain, Mayur Shah, Karthik Surabhi
Severe acute respiratory coronavirus-2 (SARS-CoV2) has shown its impending impact by causing multisystem inflammatory syndrome in children. MIS-N is an evolving entity with a skeptical presentation. Its progression is very unforeseeable and fatal. Recent studies have speculated vertical transmission of immunoglobulins (IgG) to the fetus. Along with the antibodies, some cytokines might cross the placenta and induce a systemicinflammatory response in the newborn. Infection and subsequent hyperinflammatory process appears to have occurred in two different individuals (i.e. infection in mother and Mis-N in neonates). It typically occurs 2-6 weeks after acute SARS-CoV-2 infection. Angiotensin-converting enzyme II (ACE2) was known to be the cell receptor for SARS-CoV.1 It is speculated that children were less sensitive to 2019-nCoV than adults due to the immaturity and binding ability of ACE2 in children.2 Additionally, children have a higher levels of antibody against virus than adults. Furthermore, children’s immune systems are still developing and may respond to pathogens differently from adult immune systems. However, it has been found that the proportion of severe and critical cases was 10.6%, 7.3%, 4.2%, 4.1%, and 3.0% for the age groups <1, 1 to 5, 6 to 10, 11 to 15, and >15 years, respectively.3 These results suggest that young children, particularly infants, were vulnerable to 2019-nCoV infection. Therefore, the mechanism for the difference in clinical manifestations between children and adults remains to be determined.
严重急性呼吸道冠状病毒-2 (SARS-CoV2)通过引起儿童多系统炎症综合征显示出其迫在眉睫的影响。MIS-N是一个不断发展的实体,具有怀疑的表现形式。它的发展是非常不可预见和致命的。最近的研究推测免疫球蛋白(IgG)垂直传播给胎儿。与抗体一起,一些细胞因子可能穿过胎盘,在新生儿中引起全身炎症反应。感染和随后的高炎症过程似乎发生在两个不同的个体中(即母亲感染和新生儿感染misn)。它通常发生在急性SARS-CoV-2感染后2-6周。已知血管紧张素转换酶II (ACE2)是SARS-CoV.1的细胞受体推测儿童对2019-nCoV的敏感性低于成人,可能与ACE2在儿童中的不成熟和结合能力有关此外,儿童的抗病毒抗体水平高于成人。此外,儿童的免疫系统仍在发育,对病原体的反应可能与成人的免疫系统不同。15岁年龄组重症和危重病例分别为10.6%、7.3%、4.2%、4.1%和3.0%这些结果表明,幼儿,特别是婴儿,易受2019-nCoV感染。因此,儿童与成人临床表现差异的机制尚不清楚。
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引用次数: 1
Study of Cord Blood Lipid Levels and Its Correlation with Newborn’s Birth Weight and Gestational Age 新生儿出生体重、胎龄与脐带血血脂水平相关性的研究
Pub Date : 2022-01-01 DOI: 10.26502/jppch.74050132
Joshi Siddhartha J, Nidhi Rai Gupta, Heloise Stanley
, Abstract Background and objectives: The genesis of atherosclerotic lesions which is a major cardiovascular risk factor starts in the early life. If the premature development of cardiovascular risk factors can be anticipated during childhood, cardiovascular events can be prevented effectively by taking appropriate measures. The aim of the present study was to know cord blood lipid levels and its correlation with newborn’s birth weight and gestational age. Methods: Present study was conducted in the department of paediatrics, Sanjay Gandhi Memorial Hospital, Mangolpuri, Delhi, from December 2019 to June 2020. In this observational cross sectional study, 105 newborn babies whose gestational age was between 28 to <42 weeks were included with due consideration of inclusion and exclusion criteria as per study protocol. Results: Cord blood lipid levels were significantly high (P <0.05) in low birth weight babies. Cord high density lipoprotein with gender (p>0.05). Conclusions: Lipid levels were significantly high in low birth weight babies, preterm babies and small for gestational age babies. Hence, low birth weight babies, small for gestational age babies and preterm babies should be closely monitored for lipid related disorders and co-morbidities.
背景与目的:动脉粥样硬化病变是一种主要的心血管危险因素,其发生始于生命早期。如果可以在儿童期预测到心血管危险因素的过早发展,就可以通过采取适当的措施有效地预防心血管事件。本研究的目的是了解脐带血血脂水平及其与新生儿出生体重和胎龄的关系。方法:本研究于2019年12月至2020年6月在德里曼戈尔普里桑杰甘地纪念医院儿科进行。在这项观察性横断面研究中,105名胎龄在28 ~ 0.05之间的新生儿。结论:低出生体重儿、早产儿和小胎龄儿的脂质水平明显高。因此,低出生体重儿、小于胎龄儿和早产儿应密切监测脂质相关疾病和合并症。
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引用次数: 0
Neglected Baby with Various Insect and Leech Bites at Cemetery: A Case Report 被忽视的婴儿与各种昆虫和水蛭咬在墓地:一个案例报告
Pub Date : 2022-01-01 DOI: 10.26502/jppch.74050097
J. Rompis, Rocky Willar, Shekina H. E. Rondonuwu, Felicia Halim
and Bites at A Case
咬一个箱子
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引用次数: 0
The Developmental Outcomes of Children Born to Parental Substance Abusers Supported by Local Counselling Centres for Psychotropic Substance Abusers in Hong Kong 父母滥用药物者所生子女在本港本地精神药物滥用者辅导中心的发展结果
Pub Date : 2022-01-01 DOI: 10.26502/jppch.74050098
Jiaye Lin, Maria Ming-Po Lai, Katy Kit-Ying Wan, Anna Wai-Fun Cheng, Benny Chung-Ying Zee
The Developmental Outcomes of Children Born to Parental Substance Abusers Supported by Local Counselling Centres for Psychotropic Substance Abusers in Kong. Journal of Pediatrics, Perinatology and Child Health 6 (2022): 145-154. Abstract Background: Even though the harmful influences of parental substance abuse on children have been well studied globally, statistics on these children’s impacts in Hong Kong were not generally available. In this study, we aimed to assess the effects of drug-abusing parents on their children via a previous survey conducted at local drug treatment and rehabilitation centres in Hong Kong. Journal of Pediatrics, Perinatology and Child Health Methods: Data were collected from 124 previous surveys of substance abuse parents having children under the age of 12 using convenient sampling. The survey consisted of three domains, totalling 34 questions: basic information about the participants and their families, substance abuse experiences in the past six months, and the history of received services. Results: Substance abuse parents had a high wido-wed/divorced/separated rate and unemployment rate. They were less likely to take care of children by themselves, especially substance abuse fathers, 17.62 times than substance abuse mothers (p<0.001). A high proportion of children at primary school age (6-12) were diagnosed or suspected special education needs (SEN) cases, accounting for 13.3%. About 15% of children and their parents showed child abuse risk factors. Conclusions: The parental substance abuse and the family’s poor marital and financial conditions negatively affected the optimal care and good-enough parenting provision for children, leading to poor developmental outcomes and an increased risk of behaviour problems.
由香港本地精神药物滥用者辅导中心支援的药物滥用者父母所生子女的发展结果。儿科,围产期和儿童健康杂志6(2022):145-154。背景:尽管父母药物滥用对儿童的有害影响在全球范围内得到了很好的研究,但在香港,这些儿童的影响的统计数据并不普遍。在本研究中,我们的目的是通过先前在香港本地戒毒治疗和康复中心进行的调查来评估滥用药物的父母对其子女的影响。方法:采用方便抽样法,收集124名有12岁以下儿童的药物滥用父母的调查数据。调查包括三个领域,共34个问题:参与者及其家庭的基本信息、过去六个月的药物滥用经历和接受服务的历史。结果:药物滥用父母的丧偶/离婚/分居率和失业率较高。他们更不愿意独自照顾孩子,尤其是药物滥用父亲,是药物滥用母亲的17.62倍(p<0.001)。小学学龄(6-12岁)儿童被诊断或疑似特殊教育需要(SEN)的比例较高,占13.3%。大约15%的儿童及其父母表现出受虐待的危险因素。结论:父母药物滥用和家庭不良的婚姻和经济状况对儿童的最佳照顾和良好的养育提供产生负面影响,导致儿童发育不良,行为问题风险增加。
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引用次数: 0
Prevalence and Risk Factors of Apnea in Preterm Neonates Admitted to the French Medical Institute for Mothers and Children Hospital in Kabul City: An Analytic Cross-Sectional Study 喀布尔市法国妇幼医学研究所医院收治的早产儿呼吸暂停患病率及危险因素:一项横断面分析研究
Pub Date : 2022-01-01 DOI: 10.26502/jppch.74050128
Mansoor Aslamzai MD, Omid Faizi MD, Basir Ahmad Froogh MD, Mohammad Farouq Hamidi MD, Sayed Azam Sajid MD
Introduction: Prematurity is one of the leading causes of neonatal death in Afghanistan and complicates a lot of serious problems including apnea. Although recurrent and prolong apnea of prematurity (AOP) may be directly or indirectly associated with significant adverse outcomes, there isn’t enough scientific information regarding the prevalence and risk factors of this problem in Afghanistan, therefore, this study was performed to obtain such information. Objective: To determine the prevalence rate and risk factors for apnea of prematurity in neonates admitted to the Neonatal Intensive Care Unit of the Patients and Methods: This analytic cross-sectional study was conducted at the Neonatal Intensive Care Unit of the French Medical Institute for Mothers and Children Hospital in Kabul City, Afghanistan. The study participants were preterm neonates. Statistical analysis was performed by SPSS 24. Results: A total of 75 preterm newborns were enrolled in this study and the apnea of prematurity were developed in 48% of them. The prevalence of such apnea was 71.4% in extremely low birth weight preterm neonates, 47.4% in very low birth weight neonates, and 36.4% in low birth weight neonates. Based on gestational age, the prevalence rates of apnea in the early and moderate preterm neonates were 55.6% and 52.8% respectively, whilst also in late preterm neonates it was 42.8%. The apnea of prematurity appeared more prevalent in boys (54.3%) than girls (45.7%). The preterm neonates in the apnea group versus the non-apnea group had the mean birth weight of (1233.33±235.25g vs 1333.46 ±274.44g, 90%CI= -198 _ -1.4), mean maternal age of (24.78±3.68y vs 26.62 ±4.58y, 90%CI= -3.44_-0.23) and RR of anemia (2.2, P=0.05). Conclusion: The overall prevalence rate of AOP in preterm neonates was 48% and the highest rates were seen within extremely low birth weight and early preterm neonates. Lower neonatal birth weight, neonatal anemia and younger maternal age were found to be the risk factors for apnea of prematurity.
前言:早产是阿富汗新生儿死亡的主要原因之一,并使包括呼吸暂停在内的许多严重问题复杂化。虽然复发性和延长性早产呼吸暂停(AOP)可能直接或间接与显著的不良后果相关,但关于该问题在阿富汗的患病率和危险因素的科学信息不足,因此,本研究旨在获得这些信息。目的:确定新生儿重症监护病房收治的早产儿呼吸暂停的患病率和危险因素及方法:本分析横断面研究在阿富汗喀布尔市法国医学研究所妇幼医院新生儿重症监护病房进行。这项研究的参与者是早产儿。采用SPSS 24进行统计学分析。结果:本研究共纳入75例早产儿,其中48%出现早产呼吸暂停。这种呼吸暂停在极低出生体重早产儿中患病率为71.4%,在极低出生体重新生儿中患病率为47.4%,在低出生体重新生儿中患病率为36.4%。按胎龄分,早期和中度早产儿呼吸暂停患病率分别为55.6%和52.8%,晚期早产儿呼吸暂停患病率为42.8%。早产呼吸暂停在男孩(54.3%)中比女孩(45.7%)更为普遍。呼吸暂停组与非呼吸暂停组早产儿的平均出生体重为(1233.33±235.25g vs 1333.46±274.44g, 90%CI= -198 _ -1.4),平均产妇年龄为(24.78±3.68y vs 26.62±4.58y, 90%CI= -3.44_-0.23),贫血RR为(2.2,P=0.05)。结论:AOP在早产儿中总体患病率为48%,以极低出生体重和早期早产儿发生率最高。新生儿出生体重过低、新生儿贫血和母亲年龄过小是早产呼吸暂停的危险因素。
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引用次数: 0
Mediation by Executive Functions in the Associations Between Perceived Stress, Prenatal Distress, Emotional Control, and Dietary Intake in Overweight or Obese Pregnant Women. 执行功能对超重或肥胖孕妇感知到的压力、产前压力、情绪控制和饮食摄入之间关系的调解作用。
Pub Date : 2022-01-01 Epub Date: 2022-10-28 DOI: 10.26502/jppch.74050131
Mei-Wei Chang, Alai Tan, Jonathan Schaffir, Duane T Wegener, Brett Worly, Katherine Strafford, Cassandra Sampsell, Kaleena Kemper, Loriana Soma, Maggie Rosen, Amanthi Ranatunga, Michelle Challa

Background: The study explored potential mediation by executive functions (behavioral regulation index [BRI] and metacognition index [MI]) in association between perceived stress, prenatal distress, emotional control, and dietary intake (total calorie, total fat, added sugar, fruits, and vegetables).

Methods: 70 overweight or obese pregnant women completed validated online surveys and two 24-hour dietary recalls. Path analyses were performed.

Results: Increased perceived stress was associated with increased BRI both directly (p < 0.001) and indirectly through increased MI (perceived stress to MI: p < 0.001, MI to BRI: p < 0.001). Subsequently, increased BRI was associated with increased total fat intake (p = 0.01). Two-stage mediation was found in the association of prenatal distress with total fat intake. Increased prenatal distress was associated with increased MI (p < 0.001). Higher MI was associated with higher BRI (p < 0.001), and higher BRI was associated with increased total fat intake (p = 0.01).

Conclusions: Future intervention studies for overweight or obese pregnant women might focus on stress management to alleviate perceived stress and prenatal distress or on strategies to boost executive functions, each of which might ultimately help to reduce total fat intake.

研究背景该研究探讨了执行功能(行为调节指数[BRI]和元认知指数[MI])在感知压力、产前困扰、情绪控制和饮食摄入(总热量、总脂肪、添加糖、水果和蔬菜)之间的潜在中介作用。进行了路径分析:感知压力的增加与 BRI 的增加直接相关(p < 0.001),并通过 MI 的增加间接相关(感知压力与 MI 的关系:p < 0.001,MI 与 BRI 的关系:p < 0.001)。随后,BRI 的增加与总脂肪摄入量的增加有关(p = 0.01)。产前焦虑与总脂肪摄入量之间的关系存在两级中介。产前困扰的增加与 MI 的增加有关(p < 0.001)。较高的MI与较高的BRI相关(p < 0.001),而较高的BRI与较高的总脂肪摄入量相关(p = 0.01):结论:未来针对超重或肥胖孕妇的干预研究可能会侧重于压力管理,以减轻感知到的压力和产前困扰,或侧重于提高执行功能的策略,这两种方法最终都可能有助于减少总脂肪摄入量。
{"title":"Mediation by Executive Functions in the Associations Between Perceived Stress, Prenatal Distress, Emotional Control, and Dietary Intake in Overweight or Obese Pregnant Women.","authors":"Mei-Wei Chang, Alai Tan, Jonathan Schaffir, Duane T Wegener, Brett Worly, Katherine Strafford, Cassandra Sampsell, Kaleena Kemper, Loriana Soma, Maggie Rosen, Amanthi Ranatunga, Michelle Challa","doi":"10.26502/jppch.74050131","DOIUrl":"10.26502/jppch.74050131","url":null,"abstract":"<p><strong>Background: </strong>The study explored potential mediation by executive functions (behavioral regulation index [BRI] and metacognition index [MI]) in association between perceived stress, prenatal distress, emotional control, and dietary intake (total calorie, total fat, added sugar, fruits, and vegetables).</p><p><strong>Methods: </strong>70 overweight or obese pregnant women completed validated online surveys and two 24-hour dietary recalls. Path analyses were performed.</p><p><strong>Results: </strong>Increased perceived stress was associated with increased BRI both directly (p < 0.001) and indirectly through increased MI (perceived stress to MI: p < 0.001, MI to BRI: p < 0.001). Subsequently, increased BRI was associated with increased total fat intake (p = 0.01). Two-stage mediation was found in the association of prenatal distress with total fat intake. Increased prenatal distress was associated with increased MI (p < 0.001). Higher MI was associated with higher BRI (p < 0.001), and higher BRI was associated with increased total fat intake (p = 0.01).</p><p><strong>Conclusions: </strong>Future intervention studies for overweight or obese pregnant women might focus on stress management to alleviate perceived stress and prenatal distress or on strategies to boost executive functions, each of which might ultimately help to reduce total fat intake.</p>","PeriodicalId":73894,"journal":{"name":"Journal of pediatrics, perinatology and child health","volume":"1 1","pages":"466-474"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69350362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Neutrophil-Lymphocyte Ratio in the Prediction of Systemic Infection in Normal Newborns in Lubumbashi: Cross-Sectional Study 鲁本巴希正常新生儿中性粒细胞-淋巴细胞比值预测全系统感染的评估:横断面研究
Pub Date : 2022-01-01 DOI: 10.26502/jppch.74050110
Amir Yuma N’Simbo Assumani, A. Nkodila, Jean Lambert Ehungu Gini, Gray Kateng A Wakamb, Gauthier Kasansaika Mutoba, Kasim N’simbo Sangwa, Maguy Omoy Ngongo, Stanislas Okitosho Wembonyama, O. Luboya
Evaluation of the Neutrophil-Lymphocyte Ratio in the Prediction of Systemic Infection in Normal Newborns in Lubumbashi: Cross-Sectional Study. Journal of Pediatrics, Perinatology and Child Health 6 (2022): 305-313. Abstract Background and Purpose: Despite progress in the surveillance of newborns Journal Health ratio (NLR) to predict systemic infection in newborns in clinics in Lubumbashi. Methods: Cross-sectional and analytical study that included 430 normal newborns in 25 medical facilities in the city of Lubumbashi, chosen in a simple random manner during the period from November 2015 to December 2017. The clinical and biological characteristics of newborns were studied. Results: out of 430 children who performed a complete blood count, 106 had an NLR> 3, a frequency of systemic infection of 24.7%. The mean values of neutrophils, lymphocytes, esosinophils, basophils monocytes were significantly higher in patients with an NLR> 3. Mean RNL values were 2.5 ± 1.2, it was 1.9 ± 0.6 in children with NLR≤3, and 4.3 ± 1.2 in those with RNL> 3. The area under the curve (AUC) for NLR, Neutrophil, Lymphocyte and Platelet were 0.887, respectively; 0.738, 0.639 and 0.552. NLR is more sensitive and specific in predicting systemic infection compared to neutrophil, lymphocyte and platelet count. Conclusion: The results show that NLR is an effective indicator in the diagnosis of systemic infection than neutrophil, lymphocyte and platelet count.
鲁本巴希正常新生儿中性粒细胞-淋巴细胞比值预测全系统感染的评估:横断面研究。儿科学,围产期与儿童健康杂志(2022):305-313。背景与目的:卢本巴希地区新生儿健康指数(NLR)监测在预测新生儿全身性感染方面取得进展。方法:采用简单随机方法选取2015年11月至2017年12月卢本巴希市25家医疗机构430名正常新生儿进行横断面分析研究。对新生儿的临床和生物学特征进行了研究。结果:在进行全血细胞计数的430名儿童中,106名有NLR bb0.3,全身性感染的频率为24.7%。中性粒细胞、淋巴细胞、嗜酸性粒细胞、嗜碱性粒细胞单核细胞的平均值在NLR患者中显著升高[3]。平均RNL值为2.5±1.2,NLR≤3组为1.9±0.6,RNL≤3组为4.3±1.2。NLR、中性粒细胞、淋巴细胞和血小板的曲线下面积(AUC)分别为0.887;0.738, 0.639和0.552。与中性粒细胞、淋巴细胞和血小板计数相比,NLR在预测全身感染方面更敏感和特异性。结论:NLR比中性粒细胞、淋巴细胞和血小板计数更能有效诊断全身性感染。
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引用次数: 0
A Study on Duplex Doppler Ultrasonography as a Non-Invasive Test for Diagnosis of Portal Hypertension in Children Attending a Tertiary Care Hospital in Bangladesh 双多普勒超声无创诊断孟加拉三级医院儿童门静脉高压症的研究
Pub Date : 2022-01-01 DOI: 10.26502/jppch.74050092
Marjan P, Karim Asmb, Rukunuzzaman M, Das Sr, M. M, S. N, Akther H, Nahar L, Chowdhury As
Bangladesh Professor and Chairman, Department of Pediatric Gastroenterology and Nutrition, BSMMU, Dhaka, Bangladesh Medical Officer, Department of Pediatric Gastroenterology and Nutrition, BSMMU, Dhaka, Bangladesh Medical Officer, Upazila Health Complex, Munshiganj, Bangladesh Assistant Professor (Paediatrics), Bangabandhu Sheikh Mujib Medical College, Faridpur, Bangladesh Medical Officer, Upazila Health Complex, Shariatpur, Bangladesh Registrar (Pediatric Gastroenterology), Dhaka Medical College Hospital, Dhaka, Bangladesh Junior Consultant, Department of Paediatrics and NICU, Labaid Specialized Hospital, Dhaka, Bangladesh
孟加拉国教授兼主席,达卡BSMMU儿科胃肠病学和营养学系,孟加拉国医生,达卡BSMMU儿科胃肠病学和营养学系,孟加拉国医生,Munshiganj,孟加拉国助理教授(儿科),Bangabandhu Sheikh Mujib医学院,Faridpur,孟加拉国医生,shaariatpur, Upazila卫生中心,孟加拉国注册主任(儿科胃肠病学),达卡医学院医院,孟加拉国达卡,拉贝德专科医院儿科和新生儿重症监护室初级顾问
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引用次数: 0
Sedation with Midazolam - Ketamine Versus Propofol In Children Undergoing Magnetic Resonance Imaging: A Randomized Comparative Study 咪达唑仑-氯胺酮与异丙酚在儿童核磁共振成像中的镇静作用:一项随机比较研究
Pub Date : 2022-01-01 DOI: 10.26502/jppch.74050122
Palak Garg, P. Yadav, Susheel kumar saini, Priyadarashani, Ajay kumar saini, S. Kumari
Objective: To evaluate the sedative effect, hemodynamics, respiratory effects, and incidence of complications of Propofol compared with Ketamine-Midazolam in children undergoing MRI examination. Study design: In this prospective single-blinded randomized comparative study, conducted at the Department of Pediatrics, Artemis Hospital, Gurugram 100 children admitted for MRI on a daycare basis were included. Children were assigned in two groups randomly; 50 children in each group. One group was given Midazolam – Ketamine (Group A) while other was given Propofol (Group B) for sedation
目的:比较异丙酚与氯胺酮咪达唑仑在儿童MRI检查中的镇静作用、血流动力学、呼吸作用及并发症发生率。研究设计:在这项前瞻性单盲随机比较研究中,在Artemis医院儿科进行,Gurugram, 100名儿童在日托基础上接受MRI检查。儿童被随机分为两组;每组50名儿童。一组给予咪达唑仑-氯胺酮(A组),另一组给予异丙酚(B组)镇静
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引用次数: 0
Type of Delivery and Functional Constipation at 48 Months of Age: Cohort Study 48月龄分娩类型与功能性便秘:队列研究
Pub Date : 2022-01-01 DOI: 10.26502/jppch.74050103
Analida Pinto Buelvas, Bianca Del Ponte, A. Matijasevich, D. Marques, I. Santos, R. Mattiello
Santos. Type of Delivery and Functional Constipation at 48 Months of Age
桑托斯。48月龄分娩类型与功能性便秘的关系
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引用次数: 0
期刊
Journal of pediatrics, perinatology and child health
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