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Johne’s Disease Vaccines Past, Present and Future 约翰氏病疫苗的过去、现在和未来
Pub Date : 2018-08-24 DOI: 10.19080/aibm.2018.11.555807
Bhupendra Nath Tripathi
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引用次数: 0
Probiotics: A Promising Anti-Cancer Agent 益生菌:一种很有前途的抗癌剂
Pub Date : 2018-08-23 DOI: 10.19080/aibm.2018.10.555783
B. Saud
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引用次数: 3
Geographical Distribution of Sugarcane Longhorn Stem Borer, Dorysthenes buqueti Guerin (Coleoptera: Cerambycidae) and Virulence Bioassay of Metarhizium anisopliae (Metchnikoff) Sorokin Isolates 甘蔗长角茎螟虫的地理分布及金龟子绿僵菌(Metchnikoff) Sorokin分离株的毒力测定
Pub Date : 2018-08-21 DOI: 10.19080/AIBM.2018.10.555782
Nichanun Kernasa
Sugarcane stem boring grub; Dorysthenes buqueti Guerin (Coleoptera: Cerambycidae) recently become a serious insect pest of sugarcane. The severe injury by D. buqueti has been extended to sugarcane growing areas i.e.; East and Northeastern region of Thailand -. It can cause more than 70% yield loss in the outbreak areas. This insect pest attack sugarcane plant by the larval instar bores into the ratoon or the base of stalk and feed sugarcane tissue inside; which results the whole plant turned brown and die. Moreover; it can attack cassava stem and tuber that found in Kanchanaburi province. The concern of extensive insecticide application has been enforced explorations of natural enemies to control D. buqueti. Metarhizium anisopliae (Metchnikoff) Sorokin is a soil borne entomopathogenic fungus had been reported to exploiting to control D. buqueti in sugarcane fields. Metarhizium spp. are always designated as soil saprophytes that were observed in associations with plant roots in the rhizosphere stage and survive well in that environment over the longtime [1]. The Green Abstract
甘蔗茎镗蛴螬;牛虻(鞘翅目:天牛科)是近年来甘蔗生产中的一种严重害虫。布奎地螨的严重危害已扩大到甘蔗种植区;泰国东部和东北部地区。它可导致疫情地区70%以上的产量损失。这种害虫通过幼虫幼虫钻入甘蔗叶片或茎秆基部,捕食甘蔗内部的组织;这导致整个植物变成棕色并死亡。此外;它可以攻击在北碧府发现的木薯茎和块茎。由于杀虫剂的广泛使用,对布氏夜蛾天敌进行了研究。金龟子绿僵菌(Metarhizium anisopliae (Metchnikoff) Sorokin)是一种经土壤传播的昆虫病原真菌,已被报道用于防治甘蔗田的金龟子病。绿僵菌属(Metarhizium spp.)一直被认为是土壤腐生植物,在根际阶段与植物根系密切相关,并在该环境中长期存活[1]。绿色文摘
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引用次数: 0
Facts File (Extended) of Pune University Pharmaceutical Institutions Privately Manage Shares Misleading Story. Towards the View of Culturally Determined Agency 事实文件(扩展)浦那大学制药机构私下管理股票的误导故事。论文化决定的能动性
Pub Date : 2018-08-16 DOI: 10.19080/AIBM.2018.10.555781
T. Belete
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引用次数: 1
The Role of Conventional and Molecular Techniques for Chickpea (Cicer arietinum L) Improvement 常规技术和分子技术在鹰嘴豆改良中的作用
Pub Date : 2018-08-15 DOI: 10.19080/aibm.2018.10.555780
T. Belete
Crops improvement depends on the availability of gene for better agronomic traits, disease resistance, earliness and high yield [1]. For this, characterization of genetic variability of a population is required since genetic variation within population and between species determines the rate of adaptive evolution and response to traditional crop improvement [2]. Genetic diversity is a raw material for evolution, thus enabling populations of species to survive, evolve and adapt to resist longterm changes in the environment. This is very important in the plant breeding strategies for developing high yielding varieties and for maintaining the productivity of such varieties through introduction of genes for resistance to disease, insect pests and other abiotic factor [3]. Genetic diversity of domestic species allows people to act as agents of selection and develop different forms of the same species for a variety of purposes, including enabling the producers to grow the same species in different environments, each with a different requirement of climate, pathogens, predators, competitors etc [2]. Differences within and between plants can be a strategic value to conservation as they provide a clear justification for protecting a species across its entire geographic range and all the subspecies of major populations.
作物改良依赖于基因的有效性,以获得更好的农艺性状、抗病、早熟和高产[1]。为此,需要对群体的遗传变异进行表征,因为群体内部和物种之间的遗传变异决定了适应性进化的速度和对传统作物改良的反应[2]。遗传多样性是进化的原材料,从而使物种种群能够生存、进化和适应,以抵御环境的长期变化。这对于培育高产品种以及通过引入抗病、抗虫等非生物因子基因来保持高产品种的生产力具有重要意义[3]。家养物种的遗传多样性使人们能够作为选择的代理人,为各种目的发展同一物种的不同形式,包括使生产者能够在不同的环境中种植同一物种,每种环境对气候、病原体、捕食者、竞争对手等都有不同的要求[2]。植物内部和植物之间的差异对保护具有战略价值,因为它们为保护一个物种在其整个地理范围内和主要种群的所有亚种提供了明确的理由。
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引用次数: 2
Secreted in Xylem (Six) Genes in Fusarium oxysporum f. sp. cubenseand Their Potential Acquisition by Horizontal Transfer 立方尖孢镰刀菌木质部分泌(6)基因及其水平转移获得潜力
Pub Date : 2018-08-13 DOI: 10.19080/aibm.2018.10.555779
Maldonado-Bonilla Luis David
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引用次数: 1
Human Genetic Association Studies: association between of Human genome with Clinical outcome 人类基因关联研究:人类基因组与临床结果的关系
Pub Date : 2018-08-10 DOI: 10.19080/aibm.2018.10.555778
F. Khatoon
The use of Genome Wide Association Studies for detecting many diseases of forensic interest and traits for sex distributions are due to sex associated variations in prevalence [1]. The sex and ancestry related data and genetic information are important components for Quantity Check (QC) in GWAS and can be implemented in practice to remove misidentifications of samples and stratifications in population samples. The approach to identify the mis-identification in processes where strong associations are detected between genotype and phenotype characteristics can be inferred if the observed phenotype is expected to be caused by the observed genotype for every subject within the study[2].
使用全基因组关联研究来检测法医感兴趣的许多疾病,性别分布的特征是由于患病率的性别相关差异[1]。性别和祖先相关数据和遗传信息是GWAS中数量检查(QC)的重要组成部分,可以在实践中实施,以消除样本的错误识别和群体样本的分层。如果观察到的表型是由研究中每个受试者的观察到的基因型引起的,那么在检测到基因型和表型特征之间存在强烈关联的过程中,可以推断出识别错误的方法[2]。
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引用次数: 2
Biofertilizers with Organic Manures: A Better Strategy for Sustainable Productivity 生物肥料与有机肥料:可持续生产力的更好策略
Pub Date : 2018-08-07 DOI: 10.19080/AIBM.2018.10.555776
Waqas Liaqat
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引用次数: 0
Antifungal Resistance and its Evolution: An Increasing Concern 抗真菌耐药性及其演变:日益受到关注
Pub Date : 2018-08-07 DOI: 10.19080/AIBM.2018.10.555777
C. Ortiz
Over the past 30 years, the importance of antifungal drugs to the practice of modern medicine has increased dramatically. Antifungal drugs used for therapy of fungal diseases can lead to antifungal resistance. Based on a study conducted by National Institute of Health, in the United States during 1980-1997, mortality rates due to invasive mycoses have been increased by 3.2 fold [1,2]. In addition, high both mortality and morbidity caused by poor diagnosis, emergence of drug-resistance and lack of effective antifungal therapy are commonly produced [2]. Nevertheless, antifungal resistance has been described for all virtually antifungal agents in several pathogens, including Candida and Aspergillus species. Additionally, azole resistance in A. fumigatus is widespread with high geographic variance since the first report of itraconazole resistance in 1997 [3]. Moreover, Candida genera exhibit resistance against almost all antifungals available, especially against Fluconazole [4-7]. For instance, C. lusitaniae and C. guillermondii are intrinsically resistant to amphotericin B [8], while other ones such as C. glabrata or C. parapsilosis are more resistant to echinocandins [3,9]. More alarming are the recent global epidemics of C. auris, which displays high resistance to all classes of antifungal drugs, eliminating effective therapeutic options [10,11]. Similarly, resistance in molds against antifungals available in the market has been demonstrated by Aspergillus fumigatus and other Aspergillus species, and even genera as Scedosporium and Fusarium [12]. For example, A. flavus and A. terreus are able to tolerate higher concentrations of amphotericin B compared to other Aspergillus species, due to different response to oxidative stress [13,14].
在过去的30年里,抗真菌药物对现代医学实践的重要性急剧增加。用于治疗真菌疾病的抗真菌药物可导致抗真菌耐药性。根据美国国立卫生研究院(National Institute of Health)在1980-1997年间进行的一项研究,侵袭性真菌病造成的死亡率增加了3.2倍[1,2]。此外,由于诊断不准确、出现耐药性以及缺乏有效的抗真菌治疗,通常会导致较高的死亡率和发病率[2]。然而,抗真菌耐药性已被描述为几种病原体中所有实际上的抗真菌剂,包括念珠菌和曲霉种。此外,自1997年首次报道伊曲康唑耐药性以来,烟曲霉对唑的耐药性广泛存在,地域差异很大[3]。此外,念珠菌属对几乎所有可用的抗真菌药物都表现出耐药性,尤其是对氟康唑[4-7]。例如,C. lusitaniae和C. guillermondii对两性霉素B具有内在抗性[8],而C. glabrata或C. parapsilosis对棘白菌素的抗性更强[3,9]。更令人担忧的是,最近全球流行的金黄色葡萄球菌(C. auris)对所有种类的抗真菌药物都表现出高度耐药性,从而使有效的治疗选择消失[10,11]。同样,霉菌对市场上销售的抗真菌药物也具有耐药性,这已被烟曲霉和其他曲霉种,甚至是镰孢曲霉属所证实[12]。例如,A. flavus和A. terreus由于对氧化应激的反应不同,与其他曲霉种类相比,它们能够耐受更高浓度的两性霉素B[13,14]。
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引用次数: 2
Inactivation and Disinfection of Poliovirus Type 1 on Nonporous Carriers 1型脊髓灰质炎病毒在非多孔载体上的灭活和消毒
Pub Date : 2018-07-02 DOI: 10.19080/AIBM.2018.09.555773
S. S. Zhou
Poliovirus is a clinically relevant enterovirus from the Picornaviridae family of non-enveloped viruses. Prior to the introduction of inactivated and attenuated poliovirus vaccines in the 1950’s, the virus caused considerable global panic from 1890 onward [1]. Although the majority of poliovirus infections result in an abortive flu-like prodrome or are asymptomatic, in ~5% of infections, a meningitic phase with varying degrees of flaccid paralytic outcome follow the prodrome [2]. Enteroviruses, including polioviruses, are viruses which are transmitted through the oral/fecal route. As implied by this, oral secretions and fecal excretions from infected individuals are capable of infecting new hosts via the gastrointestinal tract of a noninfected individual. Interruption of the cycle of infection and reinfection of enteroviruses may be facilitated by disinfection interventions that are capable of inactivating the virus. In order to be of practical use, such disinfectants should cause a significant reduction in pathogen load on environmental surfaces (fomites) under ambient conditions following a relatively short contact time. Non-enveloped viruses are not susceptible to detergents or lipid solvents, and other types of chemical disinfectants must be used. For preparation of the inactivated (Salk) poliomyelitis vaccines of the 1950’s, poliovirus was inactivated with formaldehyde. Incomplete inactivation of vaccine poliovirus leading to iatrogenic poliomyelitis in ~200 individuals was attributed to the presence of viral aggregates or of an excess of foreign protein in the inactivation solutions [1]. In particular, the presence of cell debris in the vaccine pools due to inadequate purification prevented suitable exposure of the viral particles to formaldehyde, resulting in incomplete inactivation [3,4]. Protection, by viral aggregation or by sequestering in a protein matrix, of viruses from exposure to disinfectant active agents is suggested by this unfortunate case of inactivation failure. The presence of organic load at the time of deposition of a virus onto a fomite is therefore an important factor that must be considered when assessing viral inactivation efficacy.
脊髓灰质炎病毒是一种临床相关的肠病毒,属于小核糖核酸病毒科的非包膜病毒。在20世纪50年代引入灭活和减毒脊髓灰质炎病毒疫苗之前,该病毒从1890年起引起了相当大的全球恐慌。虽然大多数脊髓灰质炎病毒感染会导致流产的流感样前驱症状或无症状,但在约5%的感染中,前驱症状之后会出现脑膜炎期,并伴有不同程度的弛缓性麻痹。肠病毒,包括脊髓灰质炎病毒,是通过口腔/粪便途径传播的病毒。由此可见,受感染个体的口腔分泌物和粪便排泄物能够通过未受感染个体的胃肠道感染新的宿主。能够使病毒失活的消毒干预措施可促进肠病毒感染周期的中断和再感染。为了实际使用,这种消毒剂应在相对较短的接触时间后,在环境条件下显著减少环境表面(污染物)上的病原体负荷。非包膜病毒对洗涤剂或脂质溶剂不敏感,必须使用其他类型的化学消毒剂。20世纪50年代,为制备灭活脊髓灰质炎疫苗(Salk),用甲醛灭活脊髓灰质炎病毒。疫苗脊髓灰质炎病毒不完全灭活导致约200人医源性脊髓灰质炎,原因是病毒聚集物的存在或灭活液中外源蛋白的过量。特别是,由于净化不足,疫苗池中存在细胞碎片,使病毒颗粒无法适当暴露于甲醛中,导致不完全失活[3,4]。这个不幸的失活失败案例表明,通过病毒聚集或隔离在蛋白质基质中,可以保护暴露于消毒剂活性剂的病毒。因此,在病毒沉积到污染物上时,有机负荷的存在是评估病毒灭活效果时必须考虑的一个重要因素。
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