Ain Shams Medical Journal最新文献

{"title":"LET-7B MICRORNA AND SIRTUIN-1 MRNA GENE EXPRESSION AS POTENTIAL BIOMARKERS FOR BREAST CANCER EGYPTIAN PATIENTS","authors":"Moatez Kamel, Doaa Gharib, Galal Ghaly, Mohamed Elhelbawy, Hadeel Shalaby, Amany Wahb","doi":"10.21608/asmj.2023.321913","DOIUrl":"https://doi.org/10.21608/asmj.2023.321913","url":null,"abstract":": Background and objectives : The most frequently detected life-threatening malignancy in women is breast cancer. We aimed to evaluate Sirtuin-1 mRNA and let-7b microRNA gene expression in breast cancer patients in Egypt and to relate them with clinicopathological features. Subjects & methods : The study recruited 225 female participants divided into the following groups: Group I: 75 patients histopathologically proven breast cancer, Group II: 75 patients histopathologically proven benign breast tumor; and Group III: 75 age matched healthy controls, from general surgery department at Menoufia University Hospital in Egypt. RT-qPCR was used to assess the expression levels of Sirtuin-1 mRNA and let-7b microRNA, while CA 15-3 was assessed by ELISA. Results: Let-7b microRNA was downregulated in breast cancer patients on comparison with benign breast tumors and control group (P< 0.001), and it was downregulated in patients with benign breast tumors compared to the control group (P <0.001). Sirtuin-1 mRNA was upregulated in the breast cancer patients compared to the benign breast tumor patients (p < 0.001) and control (p < 0.001) groups. Let-7b microRNA expression level was inversely correlated with tumor size (P=0.001; r =0.377) and affected lymph nodes (P<0.001; r=00.569). Moreover, Sirtuin-1 mRNA expression level was directly correlated with tumor size (P<0.001; r=0.438). Conclusion : Let-7b microRNA and Sirtuin-1 mRNA can be targeted for treatment and","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135738336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EMPLOYING LI-RADS ON DYNAMIC MRI SCANS FOR DISTINGUISHING HEPATOCELLULAR CARCINOMA FROM OTHER HEPATIC FOCAL LESIONS IN HIGH RISK PATIENTS","authors":"heba ellaban, Rasha Aly, Sameh Abokoura","doi":"10.21608/asmj.2023.321826","DOIUrl":"https://doi.org/10.21608/asmj.2023.321826","url":null,"abstract":": Background: LI-RADS (Liver Imaging Reporting and Data System) provide standardization for screening high risk patients for hepatocellular carcinoma (HCC). Moreover, it aids in treatment response assessment. HCC is special among different malignancies in having tumor hallmark on dynamic CT or MRI that permit accurate diagnosis without an invasive biopsy. Objective: To appraise LI-RADS on dynamic MRI scans for distinguishing hepatocellular carcinoma from other hepatic focal lesions in high risk patients. Patients and methods: This study was designed in a retrospective pattern. It included eighty five high risk patients for hepatocellular carcinoma who had undergone dynamic MRI scans. Dynamic MRI scans were evaluated using LI-RADS features for distinguishing hepatocellular carcinoma from other hepatic focal lesions. Eventually, the obtained results were correlated with serial imaging follow - up or histopathological diagnosis as the diagnostic standard of reference. Results: The majority of the included patients were found to have malignant lesions (67.1%) predominantly HCC (45.9%), followed by cholangiocarcinoma (8.2%) and finally hepatic deposits (7.1%). Considering LI-RADS categorization, hemangioma was most common among LIRAD1 group (60%), regeneration nodule among LIRAD 2 group (88.9%), dysplastic nodule among both LIRAD3 (50%) and LIRAD 4 groups (55.6). HCC among LIRAD5 group (100%). Finally, cholangiocarcinoma among LRM group (53.8 %). Conclusions: Employing LI-RADS on dynamic MRI scans for distinguishing hepatocellular carcinoma from other hepatic focal lesions in high risk patients improves patient management","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135736859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL OUTCOME OF CABG IN EGYPTIAN SEPTUAGENARIAN POPULATION","authors":"Ahmed Desoki, Ayman Ammar, Hamdy Singab, Mohamed Ghaly","doi":"10.21608/asmj.2023.321820","DOIUrl":"https://doi.org/10.21608/asmj.2023.321820","url":null,"abstract":"Background: CABG is one of the most common surgical procedures performed worldwide. The operation improves survival as well as the quality of life of patients with coronary artery heart disease. The use of the internal mammary artery (IMA) graft has become increasingly popular in CABG operations due to its demonstrated better long-term patency as compared with that of the saphenous vein graft. Aim of the Work: To determine the clinical outcome of GABG in Egyptian Septuagenarian population and to identify risk factors that may adversely affect morbidities and mortality. Patients and Methods: This nonrandomized, comparative, and prospective with propensity score matching study was conducted in department of cardiothoracic surgery Nasser Institute Hospital (NIH) and Department of cardiothoracic surgery Ain Shams University (ASU on 100 patients diagnosed to coronary artery diseases divided into 2 groups according to their age at time of operation either patient aged 70 years to 79 years or patient less than 70 years. Results: Current study results showed that there was statistically significant increase in the percentage of patients with arrhythmia, low cardiac output, reoperation, neurological complications, pulmonary complications, mediastinitis and rewiring and renal impairment in died patients than alive patients. Also, the percentage of total morbidity was found higher in died patients than alive patients. The median mechanical ventilation hours, stay on ITU hours and nights was found higher in died patients than alive patients while no statistically significant relation found between total hospital stay and mortality among patients of group B. Also, the percentage of patients with poor ejection fraction post discharge was found higher in died patients than alive patients with p-value <0.001. Conclusion: Advanced age impacts surgical outcomes after CABG with Septuagenarians having worse postoperative outcomes including higher complications and mortality than younger cases. Additionally, in Septuagenarians, females had a higher mortality than their male counterparts did. An explanation for the worse outcome in the female group is most likely multifactorial and requires additional explanation. Taken together, our results demonstrate that a careful assessment of older patients must take place to determine the best management strategy to provide coronary revascularization, we recommend versal study for more accurate analysis of the regional blood flow supply to the papillary muscle system, mitral valve and mitral apparatus by Cardiac MRI.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135736855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HISTOLOGICAL PROTECTIVE EFFECT OF WHEAT GERM OIL VERSUS ZINC ON FLUOXETINE –DAMAGED TESTES IN ALBINO RATS","authors":"heba Fawzy, Faten Mahmoud","doi":"10.21608/asmj.2023.321859","DOIUrl":"https://doi.org/10.21608/asmj.2023.321859","url":null,"abstract":": Background: Fluoxetine is anti-depressive drug which induces oxidative stress in different organs, Wheat germ oil and zinc have anti-inflammatory and antioxidant effects. Aim of the Study: to assess the histological effect of wheat germ oil (WGO) versus zinc on fluoxetine induced testicular injury in albino rats. Material & Methods: forty male albino rats were divided into four equal groups: group I (Control); group II: were received 10 mg/kg fluoxetine for 28 days; group III: administered fluoxetine + WGO at dose of 68.75 mg/kg; group IV: were received fluoxetine + zinc aspartate at dose of 30 mg/kg. samples of the testes were exposed to histological, ultrastructural and immunostaining examination. Results: fluoxetine significantly altered testicular structure. The seminefrous tubules were widely separated with significant decrease in their diameter. Separation of basal compartment of seminefrous tubules from adluminal compartment with cellular loss. This was confirmed by significant increase in Bax immunostaining. Widening of interstitial space with collagen fiber deposition was noticed. There was improvement of all histological aspects in WGO and zinc treated groups. This improvement was more evident in WGO treated group. The results were confirmed by significant increase in tubular diameter with more or less normal epithelial lining. Significant decrease in Bax immunoreaction was detected. Interstial tissue was normal .These data conclude that WGO augments the protection against fluoxetine induced testicular damage. Conclusion: fluoxetine induced oxidative damage in rat testis. W e concluded that both WGO and zinc have protective role in ameliorating fluoxetine -associated testicular injury. However, WGO has better effects on all aspects.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135736858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ELEVATED SERUM AMYLOID A LEVEL PREDICTS SEVERITY OF RADIOLOGICAL LUNG INVOLVEMENT IN HOSPITALIZED CHILDREN WITH COVID-19","authors":"Mahitab Hussein, Eman Fouda, Nancy Wahba, Maha Abd El Kareem, Mohamed Mustafa","doi":"10.21608/asmj.2023.321824","DOIUrl":"https://doi.org/10.21608/asmj.2023.321824","url":null,"abstract":": Background: Several biomarkers were studied in COVID-19 for risk stratification and monitoring disease progression. Aim of the work: We aimed to investigate the dynamics of serum amyloid A in children hospitalized with confirmed SARS-CoV-2 infection. Also, correlations with clinical presentation, disease severity score, radiological lung involvement, and outcome were studied. Patients and Methods: This controlled cross-sectional study included 60 participants divided into 2 equal groups of patients and controls. Thirty children with confirmed COVID-19 diagnosis were recruited from the Pediatric department, Children’s Hospital, Ain Shams University, from October 2020 to March 2021. Thirty age and sex-matched healthy children served as controls. Amyloid A was estimated in serum on admission (Day 1) and 10 days after treatment using ELISA method. Chest computed tomography was performed for all patients on admission. Results: At presentation, serum amyloid A was significantly higher in patients (median (IQR)= 420 (300-600)) compared to controls (median (IQR)= 50 (40-70)) (p<0.001). A cut-off value> 100 ug/ml discriminated patients from controls with 100 % sensitivity and specificity, area under the curve =1, p<0.0001. Serum amyloid A was significantly higher in patients with respiratory distress (p=0), hypoxia (p=0.003), hypotension (p=0.02), and abnormal radiological findings (p=0.03). Comparing COVID-19 severity grades, serum amyloid A was significantly higher among severe and critically ill patients (p=0.001). Serum amyloid A positively correlated with the number of affected lung lobes (r=0.46, p=0.01) and radiological severity score 9r=0.51, p=0.004). Follow-up serum amyloid A level significantly declined compared to day 1 (p=0.001). However, non-survivors showed a significant increase in serum amyloid A level (median (IQR)= 930 (840-1020)) (p=0.01). Conclusions: Serum amyloid A is a useful biomarker for severity and prognosis in children with COVID-19. Also, it can reflect severity of radiological lung involvement.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERINEURAL SPREAD IN INVASIVE FUNGAL SINUSITIS: UNDERRECOGNIZED COMPLICATION OF HEAD AND NECK INVASIVE FUNGAL INFECTION","authors":"Sameh Abokoura, Ayda Youssef, Ola Shetat, Ayman Aboalregal","doi":"10.21608/asmj.2023.321829","DOIUrl":"https://doi.org/10.21608/asmj.2023.321829","url":null,"abstract":"Background: Peri-neural spread of fungal infection is a potentially fatal condition. Identification of the major risk factors, as well as rigorous analysis of clinical features and radiological findings, may improve the chances of prompt diagnosis and better patient outcome. Aim of the work: In this study we pursue to investigate perineural spread in patients with invasive fungal infection. Patients and Methods: An institutional Review Board (IRB) approved retrospective study was conducted between April 2021 and October 2022 on 17 patients (10 male and 7 female) presented with clinical concern of fungal sinusitis and suspected perineural spread. The patients have performed contrast enhanced MRI and CT examination to evaluate sites of peri-neural extension, the involved cranial nerves, and the anatomical location. Histopathological data were obtained through surgically excised specimens in all cases. Results: In our study, the peri-neural spread was found with involvement of pterygopalatine fossa (PPF) (16 cases) (94.1%), foramen rotundum (FR) (13 cases) (76.5%), vidian canal (VC) (two cases) (11.8%), Meckel’s cave (MC) (10 cases) (58.8%), cavernous sinus (CS) (8 cases) (47%), main trigeminal nerve till pons (two cases) (11.8%), 16 out of 17 cases (94.1%) showed involvement of maxillary division of trigeminal nerve (V2) and to lesser extent ophthalmic division (V1) (only 1 case) and mandibular division (V3) (6 cases) at infra-temporal fossa. Conclusion: Peri-neural spread can occur in invasive fungal infections, and most commonly along the anatomical distribution of trigeminal nerve and its branches “especially V2”","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135736856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETROSPECTIVE ANALYSIS OF CLINICO-EPIDEMIOLOGICAL FEATURES AND OUTCOMES OF DIFFUSE LARGE B CELL LYMPHOMA IN ADULT PATIENTS TREATED AT CLINICAL ONCOLOGY DEPARTMENT, AIN SHAMS UNIVERSITY HOSPITALS","authors":"Nariman Hassan, Mai Ezz El Din, Nermean Bahie eldin, Hagar Elghazawy, Mariam Hussein, Khaled Mohamed","doi":"10.21608/asmj.2023.321831","DOIUrl":"https://doi.org/10.21608/asmj.2023.321831","url":null,"abstract":": Background: Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non-hodgkin’s lymphoma (NHL) comprising 25-30% of all NHLs worldwide. The primary site of DLBCL is important in determining the clinical features and the disease outcomes. Aim Of The Work: Analyzing the clinical, epidemiological features and outcomes including response, toxicity, and survival rates (DFS, PFS &OS) in DLBCL adult patients treated at Ain Shams University hospitals. Patient And Methods: This retrospective study included 78 DLBCL adult patients treated at Ain shams clinical oncology department from January 2016 to December 2019. Patients’ clinical characteristics and outcomes were analyzed and categorized according to the disease primary site to nodal-only, extra-nodal-only, and both nodal & extra-nodal disease. Results: The mean age at presentation was 45.54 ±15.38 years, 48.7% were 40-60 years with female predominance (57.7%). Half of the patients had early stages (I – II). The most common extra-nodal sites were bone (35.6%) and GIT (26.7%). The median IPI score was 2, with 38.5% were of low-risk. Nodal-only DLBCL (n=33) was significantly more common in males, performance 0-1, negative B-symptoms, and low risk. Extra-nodal-only DLBCL (n=11) significantly presented in females, performance (2-4), negative B-symptoms, and equally with low, high-intermediate, and high risk. Both nodal & extra-nodal DLBCL was significantly more common in females, performance 0-1, positive B-symptoms, equally bulky and non-bulky disease, and high-risk. Complete response was achieved in 56.4% and was significantly correlated with performance (0-1), negative B-symptoms, DLBCL NOS subtype, early stages (I – II), low-risk, and received R-CHOP. The 5-year DFS, PFS, and OS were 75.2%, 83.7%, and 93.8% respectively. Higher mean PFS was observed in early stages (I – II) while OS was higher in nodal-only disease. Conclusion: Nodal-only DLBCL had a characteristic clinical presentation with better prognosis and outcomes compared to extra-nodal-only DLBCL and both nodal & extranodal DLBCL.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MONOCYTE SUBSETS IN RELAPSING REMITTING MULTIPLE SCLEROSIS EGYPTIAN PATIENTS","authors":"Hala Mohamed, Rasha Saleh, Sara Taha, Shaimaa Mohamed, Nada Kamal","doi":"10.21608/asmj.2023.321832","DOIUrl":"https://doi.org/10.21608/asmj.2023.321832","url":null,"abstract":"Background: Although many types of immune cells are involved in multiple sclerosis (MS) progression, activated monocytes are believed to be one of the first to arrive at the brain and initiate inflammation. However, little is known about how the different monocyte subsets (classical, intermediate and non-classical) are involved in MS. Ain of the work: The current study aims to investigate the presence of different subsets of monocytes in relapsing-remitting MS (RRMS) Egyptian patients and their correlation with disease activity. Patients and Methods: This study included 44 RRMS patients (22 patients in relapse, 22 patients in remission), diagnosed according to the 2017 MacDonalds criteria, and 44 age-and sex-matched healthy controls. Full personal and medical histories were taken from the patients and Expanded Disability Status Scale (EDSS) was done to assess patients' disability. Characterization of monocyte subsets was done by flowcytometry for all participants. Results: The percentage of classical, intermediate, and non-classical monocyte subsets showed a statistically significant increase in MS patients than controls with p values (0.029, 0.049, 0.043) respectively. No statistically significant difference in the frequency of the classical and intermediate monocyte subsets with any of the clinical parameters. However, patients with evidence of activity in MRI have a significantly high frequency of non-classical monocytes with p value (0.002). No statistically significant difference in the frequency of the non-classical monocyte subset with the other clinical parameters. Conclusion: In MS relapse and remission, the three monocyte subsets (classical, intermediate & non-classical) increase","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135736850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OUTCOMES OF VSD REPAIR ON PATIENTS WEIGHT LESS THAN 5 KG","authors":"Kareem Ahmed, Sherif Azab, Waleed Kamel, Ayman Doghish","doi":"10.21608/asmj.2023.321812","DOIUrl":"https://doi.org/10.21608/asmj.2023.321812","url":null,"abstract":": Background: Congenital heart disease (CHD) is a range of structural anomalies of the heart, which affect around 1% of births. Individuals with CHD often require complex life ‐ saving surgeries in infancy and lifetime follow ‐ up. Very few studies have been focused on the relationship between the weight at repair and early and late outcomes. Most surgeons would prefer to correct the VSD before 6 months of age, however medical therapy is generally used in neonates, low weight young infants, and low birth-weight babies primarily because of technical concerns about the fragility of the common atrioventricular valve (CAVV) tissue. Aim of the Work: to evaluate the impact of weight less than 5 kg at operation on mortality and morbidity in patients with ventricular septal defect undergoing surgical closure. We conducted a systematic review and meta-analysis of 5 studies including neonates with weight at surgery less than 5 kilograms.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METABOLIC SYNDROME AND CLINICAL OUTCOMES IN A SAMPLE OF EGYPTIAN PATIENTS INFECTED WITH COVID-19","authors":"Marwa Daif, Amr Saleh, Tamer Ibraheem","doi":"10.21608/asmj.2023.321835","DOIUrl":"https://doi.org/10.21608/asmj.2023.321835","url":null,"abstract":": Obesity, diabetes, and hypertension are the three main components of the metabolic syndrome and risk factors for developing severe COVID-19 infection. The pro-inflammatory state of metabolic syndrome may be responsible for associated complications of COVID-19. Methodology : We conducted a retrospective cross-sectional study in Ain Shams University Isolation Hospital. A total number of 101 patients were recruited during the period from June 2021 to December 2021 , and they were divided into two groups based on whether they had the metabolic syndrome or not. Results: The majority of the admitted patients with COVID-19 were obese class I with mean = 34.72 kg/m2, and 57.4% of them were males. 59.6% of patients with metabolic syndrome had hypoxia in comparison to 38.9% of non metabolic syndrome patients who had hypoxia. They were also more vulnerable for admission in ICU than non metabolic syndrome patients , 38 (80.9%) vs 28 (51.9%) respectively. We found also statistically significant difference between patients with metabolic syndrome and non metabolic syndrome patients regarding medications and the need to receive methyl prednisolone and tocilizumab to suppress the cytokine storm, (36.2% )versus (3.7 % ) , (21.3 %) versus ( 1.9 %),(p value =0.01 ) and (p value =0.02 ) respectively. Conclusion: Metabolic syndrome is a strong risk factor for hospitalization and morbidity in a global population of hospitalized patients with COVID-19.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}