Pub Date : 2023-09-01DOI: 10.21608/asmj.2023.321857
Fatma Aboud, Menna Allah Elwafa, Mona El Bably, Nermeen Aziz
: Background: Many studies proved high percentage of vitamin D deficiency in psoriatic arthritis patients. Different records about the possible link between vitamin D deficiency and state of inflammatory & disease activity in psoriatic arthritis patients) Aim of the work: To evaluate the vitamin D level in Egyptian patients with psoriatic arthritis and its association with activity of the disease as well as disease severity Patients & Method: 45 Psoriatic Arthritis Patients fulfilled the Classification Criteria for the diagnosis of Psoriatic Arthritis (CASPAR ) and 50 healthy controls were included. Medical history was taken, general and musculoskeletal examination were done. Disease activity was assessed using the Disease activity in psoriatic arthritis "DAPSA" score . VAS, HAQ, ESR & CRP were done. Serum level of 25(OH) vitamin D was measured by ELISA for patients and controls. Results: Serum vitamin D level in psoriatic arthritis patients ranged from 10-48 ng/mL, with mean ±SD 32.844±12.395. While in healthy controls it ranged from15-50 ng/mL with mean ±SD33.940±8.998, without statistical significant difference. Vitamin D deficiency was detected in 12 patients (26.6%) and 5 (10%) healthy participants with statistically significant higher frequency of vitamin D deficiency in patients than controls (P-value <0.034). patients with vitamin D deficiency showed statistically significant longer disease duration, higher VAS, HAQ score, ESR, CRP titer and DAPSA score (P-value <0.001). Also, they had statistically significant higher frequency of axial affection (P-value <0.001). Vitamin D level was statistically negatively correlated with disease duration, VAS, HAQ, ESR, CRP and DAPSA
{"title":"VITAMIN D STATUS IN EGYPTIAN PATIENTS WITH PSORIATIC ARTHRITIS AND ITS RELATIONSHIP WITH THE DISEASE ACTIVITY AND SEVERITY.","authors":"Fatma Aboud, Menna Allah Elwafa, Mona El Bably, Nermeen Aziz","doi":"10.21608/asmj.2023.321857","DOIUrl":"https://doi.org/10.21608/asmj.2023.321857","url":null,"abstract":": Background: Many studies proved high percentage of vitamin D deficiency in psoriatic arthritis patients. Different records about the possible link between vitamin D deficiency and state of inflammatory & disease activity in psoriatic arthritis patients) Aim of the work: To evaluate the vitamin D level in Egyptian patients with psoriatic arthritis and its association with activity of the disease as well as disease severity Patients & Method: 45 Psoriatic Arthritis Patients fulfilled the Classification Criteria for the diagnosis of Psoriatic Arthritis (CASPAR ) and 50 healthy controls were included. Medical history was taken, general and musculoskeletal examination were done. Disease activity was assessed using the Disease activity in psoriatic arthritis \"DAPSA\" score . VAS, HAQ, ESR & CRP were done. Serum level of 25(OH) vitamin D was measured by ELISA for patients and controls. Results: Serum vitamin D level in psoriatic arthritis patients ranged from 10-48 ng/mL, with mean ±SD 32.844±12.395. While in healthy controls it ranged from15-50 ng/mL with mean ±SD33.940±8.998, without statistical significant difference. Vitamin D deficiency was detected in 12 patients (26.6%) and 5 (10%) healthy participants with statistically significant higher frequency of vitamin D deficiency in patients than controls (P-value <0.034). patients with vitamin D deficiency showed statistically significant longer disease duration, higher VAS, HAQ score, ESR, CRP titer and DAPSA score (P-value <0.001). Also, they had statistically significant higher frequency of axial affection (P-value <0.001). Vitamin D level was statistically negatively correlated with disease duration, VAS, HAQ, ESR, CRP and DAPSA","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/asmj.2023.321809
Ahmed Nagaty, Omar Ahmed, Khaled Elshazly, Mohamed Abd Elshafouk
: Background: Risks of inadequate decompression or neural injury during conventional Anterior Cervical Discectomy with Fusion (ACDF) surgery is not uncommon specially in cases with large posterior osteophytes or migrating fragments. Usage of High-speed Drill instead of Curettes and Kerrison Rongeurs may has a role for safe and adequate decompression. Aim: To assess the efficacy and safety of using high speed drill during ACDF surgery in comparison to conventional approach. Design: A retrospective comparative study. Methods: 60 Patients were divided into 2 groups; Group A, 30 patients who underwent Conventional ACDF surgery without using high speed drill, and group B, 30 patients underwent ACDF with the aid of high-speed drill. Results: Postoperative VAS of neck pain and Upper limbs in both groups had nearly the same end results with no statistically significant difference. In Group A: the mean Postoperative Odom’s criteria was 1.47 ± 0.629 SD, while Group B showed nearly the same values. As regards the Japanese Orthopedic Association score (JOA score), Group B showed better results with mean JOA score value equals 15.7 ± 1.02 SD, which showed statistically significant difference between both groups with p-value 0.015. In addition, Group B showed slightly better results as regards operation time and intraoperative Blood loss but with no statistically significant difference. Conclusion: High speed drill is an efficient and safe tool that can be used in ACDF surgery for adequate neural decompression, with good clinical and radiological outcomes comparable to conventional methods, even with better neurological outcome and less operative time.
{"title":"EFFICACY OF HIGH SPEED DRILL FOR SAFE AND ADEQUATE NEURAL DECOMPRESSION IN ANTERIOR CERVICAL DISCECTOMY AND FUSION SURGERIES.","authors":"Ahmed Nagaty, Omar Ahmed, Khaled Elshazly, Mohamed Abd Elshafouk","doi":"10.21608/asmj.2023.321809","DOIUrl":"https://doi.org/10.21608/asmj.2023.321809","url":null,"abstract":": Background: Risks of inadequate decompression or neural injury during conventional Anterior Cervical Discectomy with Fusion (ACDF) surgery is not uncommon specially in cases with large posterior osteophytes or migrating fragments. Usage of High-speed Drill instead of Curettes and Kerrison Rongeurs may has a role for safe and adequate decompression. Aim: To assess the efficacy and safety of using high speed drill during ACDF surgery in comparison to conventional approach. Design: A retrospective comparative study. Methods: 60 Patients were divided into 2 groups; Group A, 30 patients who underwent Conventional ACDF surgery without using high speed drill, and group B, 30 patients underwent ACDF with the aid of high-speed drill. Results: Postoperative VAS of neck pain and Upper limbs in both groups had nearly the same end results with no statistically significant difference. In Group A: the mean Postoperative Odom’s criteria was 1.47 ± 0.629 SD, while Group B showed nearly the same values. As regards the Japanese Orthopedic Association score (JOA score), Group B showed better results with mean JOA score value equals 15.7 ± 1.02 SD, which showed statistically significant difference between both groups with p-value 0.015. In addition, Group B showed slightly better results as regards operation time and intraoperative Blood loss but with no statistically significant difference. Conclusion: High speed drill is an efficient and safe tool that can be used in ACDF surgery for adequate neural decompression, with good clinical and radiological outcomes comparable to conventional methods, even with better neurological outcome and less operative time.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/asmj.2023.321830
Yasmin Moussa, Nivine Gado, Dalia El Khodary, Diaa El Din Shreef
: Background: Neoadjuvant chemotherapy (NAC) in breast cancer patients provides an excellent model for evaluation of potential predictive factors. Both clinical complete response (cCR) and pathological complete response (pCR) achieved after neoadjuvant chemotherapy is a surrogate marker for a favorable prognosis. Factors capable of predicting response such as the proliferation marker Ki67 may help improve our understanding of the drug response and its effect on the prognosis and survival. Aim of the work: The aim of this study is to investigate the predictive value of the pretreatment Ki67 regard its ability to predict response to neoadjuvant chemotherapy and to investigate potential differences in proliferation scores between pretreatment core biopsies and post treatment final surgical samples in response to neoadjuvant chemotherapy. Patients & methods: A Retrospective Study conducted on sixty (60) eligible Female Patients with Non metastatic Breast Cancer patients receiving neoadjuvant chemotherapy. in the period from January 2015 till January 2020 at breast clinic unit at Ain-Shams University Hospitals Clinical Oncology department. All Patient characteristics, clinical and pathological data and immunohistochemistry analysis and treatment related data were thoroughly collected. Results: Pretreatment Ki-67 didn’t show any significant difference with both clinical complete response (cCR) and pathological complete response (pCR) (all P > 0.05). A significant decrease in Ki-67 expression from a median 25% in core biopsy prior to therapy to 12 % in surgical specimen after NAC in non-pathological complete response (pCR) patients (P = 0.0006) Conclusion: Pretreatment K-i67 level Couldn’t play a predictive role in predicting both clinical and pathological complete response. A significant change in Ki-67 expression was observed between core biopsy and surgical specimen after neoadjuvant chemotherapy in breast cancer patients
{"title":"EVALUATION OF KI67 PREDICTIVE ROLE AND ITS DISCORDANCE BETWEEN PRETHERAPY BIOPSY AND POST THERAPY SURGICAL SPECIMEN IN BREAST CANCER PATIENTS RECEIVING NEOADJUVANT CHEMOTHERAPY.","authors":"Yasmin Moussa, Nivine Gado, Dalia El Khodary, Diaa El Din Shreef","doi":"10.21608/asmj.2023.321830","DOIUrl":"https://doi.org/10.21608/asmj.2023.321830","url":null,"abstract":": Background: Neoadjuvant chemotherapy (NAC) in breast cancer patients provides an excellent model for evaluation of potential predictive factors. Both clinical complete response (cCR) and pathological complete response (pCR) achieved after neoadjuvant chemotherapy is a surrogate marker for a favorable prognosis. Factors capable of predicting response such as the proliferation marker Ki67 may help improve our understanding of the drug response and its effect on the prognosis and survival. Aim of the work: The aim of this study is to investigate the predictive value of the pretreatment Ki67 regard its ability to predict response to neoadjuvant chemotherapy and to investigate potential differences in proliferation scores between pretreatment core biopsies and post treatment final surgical samples in response to neoadjuvant chemotherapy. Patients & methods: A Retrospective Study conducted on sixty (60) eligible Female Patients with Non metastatic Breast Cancer patients receiving neoadjuvant chemotherapy. in the period from January 2015 till January 2020 at breast clinic unit at Ain-Shams University Hospitals Clinical Oncology department. All Patient characteristics, clinical and pathological data and immunohistochemistry analysis and treatment related data were thoroughly collected. Results: Pretreatment Ki-67 didn’t show any significant difference with both clinical complete response (cCR) and pathological complete response (pCR) (all P > 0.05). A significant decrease in Ki-67 expression from a median 25% in core biopsy prior to therapy to 12 % in surgical specimen after NAC in non-pathological complete response (pCR) patients (P = 0.0006) Conclusion: Pretreatment K-i67 level Couldn’t play a predictive role in predicting both clinical and pathological complete response. A significant change in Ki-67 expression was observed between core biopsy and surgical specimen after neoadjuvant chemotherapy in breast cancer patients","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/asmj.2023.321822
Sameh Abdul-Wahab, Ali El Abd, Abeir El Hinnawy, Ehab El Fekky
: Background: Acute myocardial infarction is known to be accompanied by elevated leukocyte count. The differentiation of leukocyte types gives an added benefit of judging the severity of A.C.S. & predicting its clinical outcomes. Collecting peripheral blood samples is an easy & inexpensive test. Aim: To test the significance of Neutrophil to Lymphocyte ratio in risk stratifying patients with acute coronary syndromes and its early outcomes. Methods: One hundred patients with UA and NSTEMI were prospectively evaluated at Ain Shams University Hospital (63% UA and 37% NSTEMI). The patients were followed-up for clinical outcomes for 48 hours in-hospital & for one month after discharge. Results: The median (IQR) NLR was 8.4 (5.3 to 9.7) in NSTEMI group versus 1.8 (1.2 to 2.8) in unstable angina group, NLR > 3.9 had a sensitivity of 100%, & specificity of 92% as a diagnostic value. The patients were categorized into three groups: low risk, intermediate risk, & high risk, according to TIMI score. In unstable angina patients, the quartiles of NLR in “low risk”, “intermediate risk” and “high risk” groups were 3 (2.0, 4.3), 3.4 (2.4, 5.1) and 5.5 (3.4, 9.65). In NSTEMI patients, the quartiles of NLR in “low risk”, “intermediate risk”, and “high risk” groups were 5.1 (3.1, 8.1), 5.2 (3.0, 9.0) and 6.5 (3.9, 11.7). Meaning that there is positive correlation, as NLR values were found to be significantly elevated in high-risk groups. Conclusion: NLR on presentation, is a powerful & independent predictor of cardiovascular outcomes in patients with NSTE-ACS. It represents a good marker for stratifying patients with NSTE-ACS. It appears to have the chance of revitalization as a practical biomarker with high clinical predictability and prognostication. The easiness and swiftness of doing this test make it simple, cheap, and flawless early predictor for risk stratification in patients with NSTE-ACS.
{"title":"ROLE OF NEUTROPHIL TO LYMPHOCYTE RATIO AS A PREDICTOR IN RISK STRATIFYING PATIENTS WITH NSTE-ACS","authors":"Sameh Abdul-Wahab, Ali El Abd, Abeir El Hinnawy, Ehab El Fekky","doi":"10.21608/asmj.2023.321822","DOIUrl":"https://doi.org/10.21608/asmj.2023.321822","url":null,"abstract":": Background: Acute myocardial infarction is known to be accompanied by elevated leukocyte count. The differentiation of leukocyte types gives an added benefit of judging the severity of A.C.S. & predicting its clinical outcomes. Collecting peripheral blood samples is an easy & inexpensive test. Aim: To test the significance of Neutrophil to Lymphocyte ratio in risk stratifying patients with acute coronary syndromes and its early outcomes. Methods: One hundred patients with UA and NSTEMI were prospectively evaluated at Ain Shams University Hospital (63% UA and 37% NSTEMI). The patients were followed-up for clinical outcomes for 48 hours in-hospital & for one month after discharge. Results: The median (IQR) NLR was 8.4 (5.3 to 9.7) in NSTEMI group versus 1.8 (1.2 to 2.8) in unstable angina group, NLR > 3.9 had a sensitivity of 100%, & specificity of 92% as a diagnostic value. The patients were categorized into three groups: low risk, intermediate risk, & high risk, according to TIMI score. In unstable angina patients, the quartiles of NLR in “low risk”, “intermediate risk” and “high risk” groups were 3 (2.0, 4.3), 3.4 (2.4, 5.1) and 5.5 (3.4, 9.65). In NSTEMI patients, the quartiles of NLR in “low risk”, “intermediate risk”, and “high risk” groups were 5.1 (3.1, 8.1), 5.2 (3.0, 9.0) and 6.5 (3.9, 11.7). Meaning that there is positive correlation, as NLR values were found to be significantly elevated in high-risk groups. Conclusion: NLR on presentation, is a powerful & independent predictor of cardiovascular outcomes in patients with NSTE-ACS. It represents a good marker for stratifying patients with NSTE-ACS. It appears to have the chance of revitalization as a practical biomarker with high clinical predictability and prognostication. The easiness and swiftness of doing this test make it simple, cheap, and flawless early predictor for risk stratification in patients with NSTE-ACS.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/asmj.2023.321858
Ashraf Okba, Eman Mohamed, Rasha Shaheen, Norhan Madbouli
: Background: ICU-acquired acute kidney injury (AKI) is a common complication with numerous risk factors. Inflammatory mediators play a major role in the development of AKI. Several studies suggested a link between the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) and the occurrence of AKI. Objectives: Study a possible relationship between NLR and PLR and AKI prognosis and see if they could predict more adverse outcomes including renal replacement therapy (RRT) and mortality. Methods: 102 ICU patients with AKI were enrolled. Both CBC (to calculate NLR and PLR) and kidney function tests were performed at days 0,3,7 to study the relationship between NLR, PLR and eGFR and their correlation with the overall course of hospital stay and recovery. Results: Regarding the ability to predict mechanical ventilation, NLR had a 96% sensitivity and 81% specificity while PLR had a 92% sensitivity and 89% specificity. Both ratios had similar sensitivity in predicting shock (98%), however NLR had lower specificity. Both NLR and PLR had similar sensitivity (96.2%) and specificity (73%,71.6% respectively) in predicting the need for dialysis during hospital stay. NLR had a 50% sensitivity and 25% specificity in prediction of mortality in comparison to 50% sensitivity and 39% specificity in PLR. Conclusion: Both ratios had sufficient efficacy to predict need for mechanical ventilation, vasopressors, or dialysis. Both ratios had average accuracy in prediction of mortality.
{"title":"NEUTROPHIL TO LYMPHOCYTE RATIO AND ACUTE KIDNEY INJURY IN CRITICALLY ILL PATIENTS.","authors":"Ashraf Okba, Eman Mohamed, Rasha Shaheen, Norhan Madbouli","doi":"10.21608/asmj.2023.321858","DOIUrl":"https://doi.org/10.21608/asmj.2023.321858","url":null,"abstract":": Background: ICU-acquired acute kidney injury (AKI) is a common complication with numerous risk factors. Inflammatory mediators play a major role in the development of AKI. Several studies suggested a link between the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) and the occurrence of AKI. Objectives: Study a possible relationship between NLR and PLR and AKI prognosis and see if they could predict more adverse outcomes including renal replacement therapy (RRT) and mortality. Methods: 102 ICU patients with AKI were enrolled. Both CBC (to calculate NLR and PLR) and kidney function tests were performed at days 0,3,7 to study the relationship between NLR, PLR and eGFR and their correlation with the overall course of hospital stay and recovery. Results: Regarding the ability to predict mechanical ventilation, NLR had a 96% sensitivity and 81% specificity while PLR had a 92% sensitivity and 89% specificity. Both ratios had similar sensitivity in predicting shock (98%), however NLR had lower specificity. Both NLR and PLR had similar sensitivity (96.2%) and specificity (73%,71.6% respectively) in predicting the need for dialysis during hospital stay. NLR had a 50% sensitivity and 25% specificity in prediction of mortality in comparison to 50% sensitivity and 39% specificity in PLR. Conclusion: Both ratios had sufficient efficacy to predict need for mechanical ventilation, vasopressors, or dialysis. Both ratios had average accuracy in prediction of mortality.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Background: Bronchial asthma is a known chronic inflammatory disease. Asthma is categorized into atopic asthma and non-atopic asthma based on absence or presence of atopy which is a positive skin prick test 3 mm or Immunoglobulin E (IgE) specific antibodies that are produced against common allergens. Oxidative stress has a role in pathogenesis of bronchial asthma . Clusterin is a glycoprotein chemokine and has a role in recruitment of inflammatory cells. Aim of the Work: Our aim was to measure serum level of Clusterin in bronchial asthma patients including both (atopic and non-atopic) and to correlate it with the severity of the disease. Materials and Methods: Case control study was done on (96) adult patients diagnosed with bronchial asthma (64 atopic and 32 nonatopic), in addition to (32) sex and age matched healthy controls. Serum Clusterin & IgE levels were measured using enzyme linked immunoassay. Results: Clusterin level was higher in atopic and non-atopic patients’ groups when each was compared to control group (p<0.01, respectively). Clusterin was elevated in severe atopic asthma compared to mild and moderate atopic patients (p=0.002 and 0.003, respectively). Clusterin was elevated in moderate non atopic asthma compared to mild non atopic patients (p=0.021). Multi-ROC of IgE and Clusterin at 23 IU/mL (IgE) and 20 ng/mL (Clusterin) showed diagnostic performance efficacy (98.4%) to differentiate between control and non-atopic group. Clusterin 10 ng/mL & total IgE 125 IU/mL discriminate severe cases of bronchial asthma versus mild and moderate cases of bronchial asthma. Conclusion: Our study revealed that serum Clusterin can be a promising marker in diagnosis of bronchial asthma, and detection of degree of severity.
{"title":"ROLE OF SERUM CLUSTERIN IN BRONCHIAL ASTHMA","authors":"Heba Abou Zaghla, Mona Fathy, Shorouk El-Said, Zeinab Ashour, Marium Fathi","doi":"10.21608/asmj.2023.321834","DOIUrl":"https://doi.org/10.21608/asmj.2023.321834","url":null,"abstract":": Background: Bronchial asthma is a known chronic inflammatory disease. Asthma is categorized into atopic asthma and non-atopic asthma based on absence or presence of atopy which is a positive skin prick test 3 mm or Immunoglobulin E (IgE) specific antibodies that are produced against common allergens. Oxidative stress has a role in pathogenesis of bronchial asthma . Clusterin is a glycoprotein chemokine and has a role in recruitment of inflammatory cells. Aim of the Work: Our aim was to measure serum level of Clusterin in bronchial asthma patients including both (atopic and non-atopic) and to correlate it with the severity of the disease. Materials and Methods: Case control study was done on (96) adult patients diagnosed with bronchial asthma (64 atopic and 32 nonatopic), in addition to (32) sex and age matched healthy controls. Serum Clusterin & IgE levels were measured using enzyme linked immunoassay. Results: Clusterin level was higher in atopic and non-atopic patients’ groups when each was compared to control group (p<0.01, respectively). Clusterin was elevated in severe atopic asthma compared to mild and moderate atopic patients (p=0.002 and 0.003, respectively). Clusterin was elevated in moderate non atopic asthma compared to mild non atopic patients (p=0.021). Multi-ROC of IgE and Clusterin at 23 IU/mL (IgE) and 20 ng/mL (Clusterin) showed diagnostic performance efficacy (98.4%) to differentiate between control and non-atopic group. Clusterin 10 ng/mL & total IgE 125 IU/mL discriminate severe cases of bronchial asthma versus mild and moderate cases of bronchial asthma. Conclusion: Our study revealed that serum Clusterin can be a promising marker in diagnosis of bronchial asthma, and detection of degree of severity.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135736857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/asmj.2023.321836
Hamza Mohamed, Rasha Abdel-Razek, Mena Masaud
: Background : Traction alopecia, as a distinctive disease, was first identified in 1904 but is still a major cause of scarring hair loss in young girls worldwide. Traction alopecia is initially reversible, but if it continues, it can become an irreversible (scarring) form of alopecia. It can be seen across all races due to tightly-pulled hairstyles. The pattern of alopecia depends on the hairstyle causing it, but it most commonly affects the frontotemporal hairline. There are some new clinical features associated with traction alopecia, which are traction folliculitis, the fringe sign, and hair casts (pseudonits) on dermatoscopy. The primary treatment for traction alopecia is to discontinue the contributing excessive hairstyles. Camouflage, anti-inflammatory, or growth-stimulating topical preparations are second-line treatments. In the later stages of permanent scarring form of traction alopecia, hair transplantation may be the only effective treatment. Aim of
{"title":"EPIDEMIOLOGY OF TRACTION ALOPECIA AMONG SECONDARY SCHOOL STUDENTS IN MINIA, UPPER EGYPT","authors":"Hamza Mohamed, Rasha Abdel-Razek, Mena Masaud","doi":"10.21608/asmj.2023.321836","DOIUrl":"https://doi.org/10.21608/asmj.2023.321836","url":null,"abstract":": Background : Traction alopecia, as a distinctive disease, was first identified in 1904 but is still a major cause of scarring hair loss in young girls worldwide. Traction alopecia is initially reversible, but if it continues, it can become an irreversible (scarring) form of alopecia. It can be seen across all races due to tightly-pulled hairstyles. The pattern of alopecia depends on the hairstyle causing it, but it most commonly affects the frontotemporal hairline. There are some new clinical features associated with traction alopecia, which are traction folliculitis, the fringe sign, and hair casts (pseudonits) on dermatoscopy. The primary treatment for traction alopecia is to discontinue the contributing excessive hairstyles. Camouflage, anti-inflammatory, or growth-stimulating topical preparations are second-line treatments. In the later stages of permanent scarring form of traction alopecia, hair transplantation may be the only effective treatment. Aim of","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307091
A. Khalifa, F. Kamel, E. A. Abdel Hafez, Amr H Amer
: Background : A growing number of studies in the last few years have searched for a potential prognostic role of MDCT to improve PE risk stratification. These studies were accompanied by puzzling details and heterogeneous results. Certain CT parameters have been nominated for this purpose. RV/LV ratio and arterial obstruction index were the most extensively studied parameters. Aim of our Study: Is to investigate the prognostic role of CT pulmonary angiography in patients with acute pulmonary embolism. Patient and method: 59 patients having severe or large sized acute PE diagnosed by CT angiography were followed through 30 days to 3 months for their short-term clinical outcome. Bad outcome indicators included: PE-related mortality, clinical deterioration and necessity for ICU aggressive treatment or thrombolytics. Patients CT prognostic parameters were assessed and statistically analyzed to determine their ability to predict major adverse outcomes of acute PE. Results: Of all CT parameters, RV diameter was the best discriminator between adverse & non-adverse outcome groups in our study, comparable only to Mastora pulmonary artery obstruction score. It showed the highest negative predictive value 95.7% and a negative likelihood ratio very close to 0. RV diameter alone performed better than the commonly used RV/LV ratio as a measure of RVD in predicting PE adverse outcome. Septal bowing, substantial grades of IVC contrast reflux, PA & SVC diameters showed weak sensitivity & specificity results. A final logistic regression model combining three parameters (RV diameter + Mastora score + Age) was able to correctly define 83.9% of adverse outcome cases and 84.7% of overall cases in our study. Conclusion: Our study supported the use of CTPA-derived indicators of right ventricular dysfunction and pulmonary artery obstruction scores as prognostic predictors in patients with acute PE.
{"title":"PROGNOSTIC ROLE OF CT PULMONARY ANGIOGRAPHY IN ACUTE PULMONARY EMBOLISM","authors":"A. Khalifa, F. Kamel, E. A. Abdel Hafez, Amr H Amer","doi":"10.21608/asmj.2023.307091","DOIUrl":"https://doi.org/10.21608/asmj.2023.307091","url":null,"abstract":": Background : A growing number of studies in the last few years have searched for a potential prognostic role of MDCT to improve PE risk stratification. These studies were accompanied by puzzling details and heterogeneous results. Certain CT parameters have been nominated for this purpose. RV/LV ratio and arterial obstruction index were the most extensively studied parameters. Aim of our Study: Is to investigate the prognostic role of CT pulmonary angiography in patients with acute pulmonary embolism. Patient and method: 59 patients having severe or large sized acute PE diagnosed by CT angiography were followed through 30 days to 3 months for their short-term clinical outcome. Bad outcome indicators included: PE-related mortality, clinical deterioration and necessity for ICU aggressive treatment or thrombolytics. Patients CT prognostic parameters were assessed and statistically analyzed to determine their ability to predict major adverse outcomes of acute PE. Results: Of all CT parameters, RV diameter was the best discriminator between adverse & non-adverse outcome groups in our study, comparable only to Mastora pulmonary artery obstruction score. It showed the highest negative predictive value 95.7% and a negative likelihood ratio very close to 0. RV diameter alone performed better than the commonly used RV/LV ratio as a measure of RVD in predicting PE adverse outcome. Septal bowing, substantial grades of IVC contrast reflux, PA & SVC diameters showed weak sensitivity & specificity results. A final logistic regression model combining three parameters (RV diameter + Mastora score + Age) was able to correctly define 83.9% of adverse outcome cases and 84.7% of overall cases in our study. Conclusion: Our study supported the use of CTPA-derived indicators of right ventricular dysfunction and pulmonary artery obstruction scores as prognostic predictors in patients with acute PE.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77770902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307127
N. Hassan, N. Nabih, Tamer Ibrahim, Rana Abdelfatah
Background: Acute myeloid leukaemia is considered one of the heterogeneous hematologic cancers that have a range of therapeutic modalities, genetic abnormalities, and prognoses. AML treatment that is effective is still difficult. Increasing anti-tumor response by inhibiting immunological checkpoints is an appealing approach for leukaemia treatments. An essential immunological checkpoint known as CD200 is the ligand for CD200 receptor (CD200R), which is present on myeloid and lymphoid cells. CD200R limits anti-tumor immune responses. Aim of work: To research the relationship between CD200 and the response outcome to induction therapy in adult AML Egyptian patients. Methods: Ain Shams University's clinical pathology department, internal medicine department, clinical hematology and bone marrow transplantation center, and flow cytometry laboratory all participated in this prospective cross-sectional study on 68 adult patients who were recently diagnosed with acute myeloid leukaemia. Results: Median of CD200 expression was 7.8 (1.3–45) for the responder group compared to 87.7 (77–88.6) for the non-responder group, Compared to the responder group, the CD200 % in the non-responder group had a statistically significant greater value (p 0.001). According to the CD200 level, there was a statistically significant difference between the responder group and the non-responder group with a p-value of (p0.001). The higher positive CD200 was found in non-responder group 31 patients (100%) compared to responder group 18 patients (48.6%). Conclusion: AML development may be influenced by CD200 expression in myeloid blasts from patients with the disease. In the future, this marker's analysis may be used as a prognostic indicator and to direct treatment for
{"title":"CORRELATION BETWEEN CD200 EXPRESSION ON LEUKEMIC STEM CELLS AND RESPONSE TO TREATMENT IN DE-NOVO ADULT ACUTE MYELOID LEUKEMIA PATIENTS","authors":"N. Hassan, N. Nabih, Tamer Ibrahim, Rana Abdelfatah","doi":"10.21608/asmj.2023.307127","DOIUrl":"https://doi.org/10.21608/asmj.2023.307127","url":null,"abstract":"Background: Acute myeloid leukaemia is considered one of the heterogeneous hematologic cancers that have a range of therapeutic modalities, genetic abnormalities, and prognoses. AML treatment that is effective is still difficult. Increasing anti-tumor response by inhibiting immunological checkpoints is an appealing approach for leukaemia treatments. An essential immunological checkpoint known as CD200 is the ligand for CD200 receptor (CD200R), which is present on myeloid and lymphoid cells. CD200R limits anti-tumor immune responses. Aim of work: To research the relationship between CD200 and the response outcome to induction therapy in adult AML Egyptian patients. Methods: Ain Shams University's clinical pathology department, internal medicine department, clinical hematology and bone marrow transplantation center, and flow cytometry laboratory all participated in this prospective cross-sectional study on 68 adult patients who were recently diagnosed with acute myeloid leukaemia. Results: Median of CD200 expression was 7.8 (1.3–45) for the responder group compared to 87.7 (77–88.6) for the non-responder group, Compared to the responder group, the CD200 % in the non-responder group had a statistically significant greater value (p 0.001). According to the CD200 level, there was a statistically significant difference between the responder group and the non-responder group with a p-value of (p0.001). The higher positive CD200 was found in non-responder group 31 patients (100%) compared to responder group 18 patients (48.6%). Conclusion: AML development may be influenced by CD200 expression in myeloid blasts from patients with the disease. In the future, this marker's analysis may be used as a prognostic indicator and to direct treatment for","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"45 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72622842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307104
O. Ali, E. Fouda, Dalia Abdelhamid, B. Sherif
: Background: Cystic fibrosis (CF) is a chronic autosomal recessive disease caused by CF transmembrane conductance regulator (CFTR) gene mutations, which encodes the CFTR protein. Impaired function of this protein leads to increased mucus thickness with subsequent chronic infections . The fungal biota in CF is dominated by Aspergillus and Candida species (spp). Aim of the Work: To determine the common lower respiratory tract infections among CF pediatric patients and to correlate culture results with the patient clinical status. Patients and Methods: A Cross Sectional Study was applied on 32 lower respiratory samples collected from CF pediatric patients admitted to Chest department, Pediatric Hospital, Ain Shams University. Samples were tested through bacterial and fungal culture. Results: Bacterial growth was detected in five samples (15.6%), where Pseudomonas spp was the most common bacteria, Fungal growth was detected in three samples (9.4%), all showed growth of Candida spp. Two samples showed mixed growth of Pseudomonas spp and Candida non albicans. Conclusion: Pseudomonas spp was the most frequent pathogen isolated from CF patients. Candida spp was the predominant fungal species detected.
{"title":"SCREENING FOR LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN WITH CYSTIC FIBROSIS","authors":"O. Ali, E. Fouda, Dalia Abdelhamid, B. Sherif","doi":"10.21608/asmj.2023.307104","DOIUrl":"https://doi.org/10.21608/asmj.2023.307104","url":null,"abstract":": Background: Cystic fibrosis (CF) is a chronic autosomal recessive disease caused by CF transmembrane conductance regulator (CFTR) gene mutations, which encodes the CFTR protein. Impaired function of this protein leads to increased mucus thickness with subsequent chronic infections . The fungal biota in CF is dominated by Aspergillus and Candida species (spp). Aim of the Work: To determine the common lower respiratory tract infections among CF pediatric patients and to correlate culture results with the patient clinical status. Patients and Methods: A Cross Sectional Study was applied on 32 lower respiratory samples collected from CF pediatric patients admitted to Chest department, Pediatric Hospital, Ain Shams University. Samples were tested through bacterial and fungal culture. Results: Bacterial growth was detected in five samples (15.6%), where Pseudomonas spp was the most common bacteria, Fungal growth was detected in three samples (9.4%), all showed growth of Candida spp. Two samples showed mixed growth of Pseudomonas spp and Candida non albicans. Conclusion: Pseudomonas spp was the most frequent pathogen isolated from CF patients. Candida spp was the predominant fungal species detected.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84679929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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