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Towards Safe In Situ Needle Manipulation for Robot Assisted Lumbar Injection in Interventional MRI. 介入MRI中机器人辅助腰椎注射安全的原位针操作。
Yanzhou Wang, Gang Li, Ka-Wai Kwok, Kevin Cleary, Russell H Taylor, Iulian Iordachita

Lumbar injection is an image-guided procedure performed manually for diagnosis and treatment of lower back pain and leg pain. Previously, we have developed and verified an MR-Conditional robotic solution to assisting the needle insertion process. Drawing on our clinical experiences, a virtual remote center of motion (RCM) constraint is implemented to enable our robot to mimic a clinician's hand motion to adjust the needle tip position in situ. Force and image data are collected to study the needle behavior in gel phantoms during this motion, and a mechanics-based needle-tissue interaction model is proposed and evaluated to further examine the underlying physics. This work extends the commonly-adopted notion of an RCM for flexible needles, and introduces new motion parameters to describe the needle behavior. The model parameters can be tuned to match the experimental result to sub-millimeter accuracy, and this proposed needle manipulation method presents a safer alternative to laterally translating the needle during in situ needle adjustments.

腰椎注射是一种图像引导的人工手术,用于诊断和治疗腰痛和腿痛。此前,我们已经开发并验证了一种磁共振条件机器人解决方案,以协助针头插入过程。根据我们的临床经验,实现了一个虚拟远程运动中心(RCM)约束,使我们的机器人能够模仿临床医生的手部运动来原位调整针尖的位置。在此过程中,我们收集了力和图像数据来研究凝胶模型中针的行为,并提出了一个基于力学的针与组织相互作用模型,以进一步研究其潜在的物理特性。这项工作扩展了普遍采用的柔性针RCM概念,并引入了新的运动参数来描述针的行为。模型参数可以调整到与实验结果相匹配的亚毫米精度,并且该方法在原位调针过程中提供了一种更安全的替代方法。
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引用次数: 2
Analysis of Contact Stability and Contact Safety of a Robotic Intravascular Cardiac Catheter under Blood Flow Disturbances. 血流干扰下机器人血管内心导管的接触稳定性和接触安全性分析
Ran Hao, Nate Lombard Poirot, M Cenk Çavuşoğlu

This paper studies the contact stability and contact safety of a robotic intravascular cardiac catheter under blood flow disturbances while in contact with tissue surface. A probabilistic blood flow disturbance model, where the blood flow drag forces on the catheter body are approximated using a quasi-static model, is introduced. Using this blood flow disturbance model, probabilistic contact stability and contact safety metrics, employing a sample based representation of the blood flow velocity distribution, are proposed. Finally, the contact stability and contact safety of a MRI-actuated robotic catheter are analyzed using these models in a specific example scenario under left pulmonary inferior vein (LIV) blood flow disturbances.

本文研究了机器人血管内心脏导管与组织表面接触时在血流干扰下的接触稳定性和接触安全性。本文引入了一个概率血流扰动模型,其中导管体上的血流阻力使用准静态模型进行近似。利用该血流扰动模型,提出了概率接触稳定性和接触安全性指标,采用基于样本的血流速度分布表示法。最后,在左肺下静脉(LIV)血流干扰的特定示例场景中,使用这些模型分析了磁共振成像驱动机器人导管的接触稳定性和接触安全性。
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引用次数: 0
Auditory Feedback Effectiveness for Enabling Safe Sclera Force in Robot-Assisted Vitreoretinal Surgery: a Multi-User Study. 听觉反馈对机器人辅助玻璃体视网膜手术安全巩膜力的影响:一项多用户研究。
Ali Ebrahimi, Marina Roizenblatt, Niravkumar Patel, Peter Gehlbach, Iulian Iordachita

Robot-assisted retinal surgery has become increasingly prevalent in recent years in part due to the potential for robots to help surgeons improve the safety of an immensely delicate and difficult set of tasks. The integration of robots into retinal surgery has resulted in diminished surgeon perception of tool-to-tissue interaction forces due to robot's stiffness. The tactile perception of these interaction forces (sclera force) has long been a crucial source of feedback for surgeons who rely on them to guide surgical maneuvers and to prevent damaging forces from being applied to the eye. This problem is exacerbated when there are unfavorable sclera forces originating from patient movements (dynamic eyeball manipulation) during surgery which may cause the sclera forces to increase even drastically. In this study we aim at evaluating the efficacy of providing warning auditory feedback based on the level of sclera force measured by force sensing instruments. The intent is to enhance safety during dynamic eye manipulations in robot-assisted retinal surgery. The disturbances caused by lateral movement of patient's head are simulated using a piezo-actuated linear stage. The Johns Hopkins Steady-Hand Eye Robot (SHER), is then used in a multi-user experiment. Twelve participants are asked to perform a mock retinal surgery by following painted vessels inside an eye phantom using a force sensing instrument while auditory feedback is provided. The results indicate that the users are able to handle the eye motion disturbances while maintaining the sclera forces within safe boundaries when audio feedback is provided.

近年来,机器人辅助视网膜手术变得越来越普遍,部分原因是机器人有可能帮助外科医生提高一组极其微妙和困难的任务的安全性。由于机器人的刚度,将机器人集成到视网膜手术中导致外科医生对工具-组织相互作用力的感知减少。这些相互作用力(巩膜力)的触觉感知长期以来一直是外科医生的重要反馈来源,外科医生依靠它们来指导手术操作,并防止损伤力施加到眼睛上。当手术过程中由于患者运动(动态眼球操作)而产生不利的巩膜力时,可能导致巩膜力急剧增加,这一问题会加剧。在本研究中,我们的目的是评估基于力传感仪器测量的巩膜力水平提供警告性听觉反馈的效果。目的是提高机器人辅助视网膜手术中动态眼睛操作的安全性。由患者头部的横向运动引起的干扰是模拟使用压电驱动的线性阶段。约翰霍普金斯大学的稳定手眼机器人(SHER),随后被用于多用户实验。12名参与者被要求在提供听觉反馈的同时,通过使用力传感仪器跟踪眼幻影内涂漆的血管来进行模拟视网膜手术。结果表明,当提供音频反馈时,用户能够在处理眼动干扰的同时将巩膜力保持在安全范围内。
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引用次数: 0
Differential Image Based Robot to MRI Scanner Registration with Active Fiducial Markers for an MRI-Guided Robotic Catheter System. 基于差分图像的机器人与MRI扫描仪的主动基准标记配准,用于MRI引导机器人导管系统。
E Erdem Tuna, Nate Lombard Poirot, Juana Barrera Bayona, Dominique Franson, Sherry Huang, Julian Narvaez, Nicole Seiberlich, Mark Griswold, M Cenk Çavuşoğlu

In magnetic resonance imaging (MRI) guided robotic catheter ablation procedures, reliable tracking of the catheter within the MRI scanner is needed to safely navigate the catheter. This requires accurate registration of the catheter to the scanner. This paper presents a differential, multi-slice image-based registration approach utilizing active fiducial coils. The proposed method would be used to preoperatively register the MRI image space with the physical catheter space. In the proposed scheme, the registration is performed with the help of a registration frame, which has a set of embedded electromagnetic coils designed to actively create MRI image artifacts. These coils are detected in the MRI scanner's coordinate system by background subtraction. The detected coil locations in each slice are weighted by the artifact size and then registered to known ground truth coil locations in the catheter's coordinate system via least-squares fitting. The proposed approach is validated by using a set of target coils placed withing the workspace, employing multi-planar capabilities of the MRI scanner. The average registration and validation errors are respectively computed as 1.97 mm and 2.49 mm. The multi-slice approach is also compared to the single-slice method and shown to improve registration and validation by respectively 0.45 mm and 0.66 mm.

在磁共振成像(MRI)引导的机器人导管消融程序中,需要在MRI扫描仪内对导管进行可靠跟踪,以安全地引导导管。这需要将导管准确地对准扫描仪。本文提出了一种利用有源基准线圈的基于差分多切片图像的配准方法。所提出的方法将用于术前将MRI图像空间与物理导管空间配准。在所提出的方案中,配准是在配准框架的帮助下进行的,该配准框架具有一组嵌入式电磁线圈,设计用于主动创建MRI图像伪影。这些线圈是通过背景减法在MRI扫描仪的坐标系中检测到的。通过伪影大小对每个切片中检测到的线圈位置进行加权,然后通过最小二乘拟合将其配准到导管坐标系中的已知地面真实线圈位置。通过使用放置在工作空间内的一组目标线圈,利用MRI扫描仪的多平面功能,验证了所提出的方法。平均配准和验证误差分别计算为1.97 mm和2.49 mm。还将多切片方法与单层方法进行了比较,结果表明,配准和验证分别提高了0.45 mm和0.66 mm。
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引用次数: 1
An Optimized Tilt Mechanism for a New Steady-Hand Eye Robot. 新型稳定手眼机器人的优化倾斜机制
Jiahao Wu, Gang Li, Muller Urias, Niravkumar A Patel, Yun-Hui Liu, Peter Gehlbach, Russell H Taylor, Iulian Iordachita

Robot-assisted vitreoretinal surgery can filter surgeons' hand tremors and provide safe, accurate tool manipulation. In this paper, we report the design, optimization, and evaluation of a novel tilt mechanism for a new Steady-Hand Eye Robot (SHER). The new tilt mechanism features a four-bar linkage design and has a compact structure. Its kinematic configuration is optimized to minimize the required linear range of motion (LRM) for implementing a virtual remote center-of-motion (V-RCM) while tilting a surgical tool. Due to the different optimization constraints for the robots at the left and right sides of the human head, two configurations of this tilt mechanism are proposed. Experimental results show that the optimized tilt mechanism requires a significantly smaller LRM (e.g. 5.08 mm along Z direction and 8.77 mm along Y direction for left side robot) as compared to the slider-crank tilt mechanism used in the previous SHER (32.39 mm along Z direction and 21.10 mm along Y direction). The feasibility of the proposed tilt mechanism is verified in a mock bilateral robot-assisted vitreoretinal surgery. The ergonomically acceptable robot postures needed to access the surgical field is also determined.

机器人辅助玻璃体视网膜手术可过滤外科医生的手部震颤,并提供安全、准确的工具操作。在本文中,我们报告了新型稳定手眼机器人(SHER)的新型倾斜机构的设计、优化和评估。新型倾斜机构采用四杆连杆设计,结构紧凑。对其运动学配置进行了优化,以便在倾斜手术工具的同时,最大限度地减少实现虚拟远程运动中心(V-RCM)所需的线性运动范围(LRM)。由于人体头部左右两侧的机器人有不同的优化限制,因此提出了两种倾斜机构的配置。实验结果表明,与之前的 SHER 中使用的滑块-曲柄倾斜机构(Z 向 32.39 毫米,Y 向 21.10 毫米)相比,优化后的倾斜机构所需的 LRM 明显更小(例如,左侧机器人 Z 向 5.08 毫米,Y 向 8.77 毫米)。在模拟双侧机器人辅助玻璃体视网膜手术中,验证了所建议的倾斜机制的可行性。同时还确定了进入手术区域所需的符合人体工程学的机器人姿势。
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引用次数: 0
Towards Autonomous Control of Magnetic Suture Needles. 磁性缝合针的自主控制。
Matthew Fan, Xiaolong Liu, Kamakshi Jain, Daniel Lerner, Lamar O Mair, Irving N Weinberg, Yancy Diaz-Mercado, Axel Krieger

This paper proposes a magnetic needle steering controller to manipulate mesoscale magnetic suture needles for executing planned suturing motion. This is an initial step towards our research objective: enabling autonomous control of magnetic suture needles for suturing tasks in minimally invasive surgery. To demonstrate the feasibility of accurate motion control, we employ a cardinally-arranged four-coil electromagnetic system setup and control magnetic suture needles in a 2-dimensional environment, i.e., a Petri dish filled with viscous liquid. Different from only using magnetic field gradients to control small magnetic agents under high damping conditions, the dynamics of a magnetic suture needle are investigated and encoded in the controller. Based on mathematical formulations of magnetic force and torque applied on the needle, we develop a kinematically constrained dynamic model that controls the needle to rotate and only translate along its central axis for mimicking the behavior of surgical sutures. A current controller of the electromagnetic system combining with closed-loop control schemes is designed for commanding the magnetic suture needles to achieve desired linear and angular velocities. To evaluate control performance of magnetic suture needles, we conduct experiments including needle rotation control, needle position control by using discretized trajectories, and velocity control by using a time-varying circular trajectory. The experiment results demonstrate our proposed needle steering controller can perform accurate motion control of mesoscale magnetic suture needles.

本文提出了一种磁针转向控制器,用于操纵中尺度磁缝合针执行计划缝合运动。这是朝着我们的研究目标迈出的第一步:实现对磁性缝合针的自主控制,用于微创手术中的缝合任务。为了证明精确运动控制的可行性,我们采用了一个基数排列的四线圈电磁系统设置,并在二维环境中控制磁性缝合针,即充满粘性液体的培养皿。与在高阻尼条件下仅使用磁场梯度来控制小磁性剂不同,在控制器中研究并编码了磁性缝合针的动力学。基于施加在针头上的磁力和转矩的数学公式,我们开发了一个运动学约束的动力学模型,该模型控制针头旋转并仅沿其中心轴平移,以模拟外科缝线的行为。电磁系统的电流控制器与闭环控制方案相结合,用于命令磁性缝合针实现期望的线速度和角速度。为了评估磁性缝合针的控制性能,我们进行了实验,包括针头旋转控制、使用离散轨迹的针头位置控制和使用时变圆形轨迹的速度控制。实验结果表明,我们提出的针头转向控制器可以对中尺度磁性缝合针进行精确的运动控制。
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引用次数: 0
Optimizing Motion-Planning Problem Setup via Bounded Evaluation with Application to Following Surgical Trajectories. 通过有界评估优化运动规划问题设置,并将其应用于跟踪手术轨迹。
Sherdil Niyaz, Alan Kuntz, Oren Salzman, Ron Alterovitz, Siddhartha S Srinivasa

A motion-planning problem's setup can drastically affect the quality of solutions returned by the planner. In this work we consider optimizing these setups, with a focus on doing so in a computationally-efficient fashion. Our approach interleaves optimization with motion planning, which allows us to consider the actual motions required of the robot. Similar prior work has treated the planner as a black box: our key insight is that opening this box in a simple-yet-effective manner enables a more efficient approach, by allowing us to bound the work done by the planner to optimizer-relevant computations. Finally, we apply our approach to a surgically-relevant motion-planning task, where our experiments validate our approach by more-efficiently optimizing the fixed insertion pose of a surgical robot.

运动规划问题的设置会极大地影响规划器返回的解决方案的质量。在这项工作中,我们考虑优化这些设置,重点是以计算效率高的方式进行优化。我们的方法将优化与运动规划交织在一起,使我们能够考虑机器人所需的实际运动。之前的类似工作将规划器视为一个黑盒子:我们的主要见解是,通过简单而有效的方式打开这个黑盒子,使我们能够将规划器的工作与优化器相关的计算绑定在一起,从而实现更高效的方法。最后,我们将我们的方法应用到与外科手术相关的运动规划任务中,通过更高效地优化外科手术机器人的固定插入姿势,我们的实验验证了我们的方法。
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引用次数: 0
A Novel Semi-Autonomous Control Framework for Retina Confocal Endomicroscopy Scanning. 一种新的视网膜共聚焦内镜扫描半自主控制框架。
Zhaoshuo Li, Mahya Shahbazi, Niravkumar Patel, Eimear O' Sullivan, Haojie Zhang, Khushi Vyas, Preetham Chalasani, Peter L Gehlbach, Iulian Iordachita, Guang-Zhong Yang, Russell H Taylor

In this paper, a novel semi-autonomous control framework is presented for enabling probe-based confocal laser endomicroscopy (pCLE) scan of the retinal tissue. With pCLE, retinal layers such as nerve fiber layer (NFL) and retinal ganglion cell (RGC) can be scanned and characterized in real-time for an improved diagnosis and surgical outcome prediction. However, the limited field of view of the pCLE system and the micron-scale optimal focus distance of the probe, which are in the order of physiological hand tremor, act as barriers to successful manual scan of retinal tissue. Therefore, a novel sensorless framework is proposed for real-time semi-autonomous endomicroscopy scanning during retinal surgery. The framework consists of the Steady-Hand Eye Robot (SHER) integrated with a pCLE system, where the motion of the probe is controlled semi-autonomously. Through a hybrid motion control strategy, the system autonomously controls the confocal probe to optimize the sharpness and quality of the pCLE images, while providing the surgeon with the ability to scan the tissue in a tremor-free manner. Effectiveness of the proposed architecture is validated through experimental evaluations as well as a user study involving 9 participants. It is shown through statistical analyses that the proposed framework can reduce the work load experienced by the users in a statistically-significant manner, while also enhancing their performance in retaining pCLE images with optimized quality.

本文提出了一种新的半自主控制框架,用于实现基于探针的共聚焦激光内镜(pCLE)对视网膜组织的扫描。使用pCLE,可以实时扫描和表征视网膜各层,如神经纤维层(NFL)和视网膜神经节细胞(RGC),以提高诊断和手术结果预测。然而,pCLE系统的有限视野和探针的微米级最佳聚焦距离,在生理手部震颤的顺序上,成为成功手动扫描视网膜组织的障碍。因此,提出了一种新的无传感器框架,用于视网膜手术期间的实时半自主内镜扫描。该框架由与pCLE系统集成的稳定手眼机器人(SHER)组成,其中探头的运动是半自主控制的。通过混合运动控制策略,该系统自动控制共聚焦探头,以优化pCLE图像的清晰度和质量,同时为外科医生提供无震颤扫描组织的能力。通过实验评估和涉及9名参与者的用户研究,验证了所提出架构的有效性。通过统计分析表明,该框架可以显著减少用户的工作量,同时也提高了用户保留最佳质量的pCLE图像的性能。
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引用次数: 3
Toward Improving Patient Safety and Surgeon Comfort in a Synergic Robot-Assisted Eye Surgery: A Comparative Study. 在协同机器人辅助眼科手术中提高患者安全和外科医生舒适度:一项比较研究。
Ali Ebrahimi, Farshid Alambeigi, Ingrid E Zimmer-Galler, Peter Gehlbach, Russell H Taylor, Iulian Iordachita

When robotic assistance is present into vitreoretinal surgery, the surgeon will experience reduced sensory input that is otherwise derived from the tool's interaction with the eye wall (sclera). We speculate that disconnecting the surgeon from this sensory input may increase the risk of injury to the eye and affect the surgeon's usual technique. On the other hand, robot autonomous motion to enhance patient safety might inhibit the surgeons tool manipulation and diminish surgeon comfort with the procedure. In this study, to investigate the parameters of patient safety and surgeon comfort in a robot-assisted eye surgery, we implemented three different approaches designed to keep the scleral force in a safe range during a synergic eye manipulation task. To assess the surgeon comfort during these procedures, the amount of interference with the surgeons usual maneuvers has been analyzed by defining quantitative comfort metrics. The first two utilized scleral force control approaches are based on an adaptive force control method in which the robot actively counteracts any excessive force on the sclera. The third control method is based on a virtual fixture approach in which a virtual wall is created for the surgeon in the unsafe directions of manipulation. The performance of the utilized approaches was evaluated in user studies with two experienced retinal surgeons and the outcomes of the procedure were assessed using the defined safety and comfort metrics. Results of these analyses indicate the significance of the opted control paradigm on the outcome of a safe and comfortable robot-assisted eye surgery.

当机器人辅助进行玻璃体视网膜手术时,外科医生将体验到由于工具与眼壁(巩膜)相互作用而产生的感觉输入减少。我们推测,切断外科医生与这种感觉输入的联系可能会增加眼睛受伤的风险,并影响外科医生的常规技术。另一方面,为了提高患者的安全性,机器人的自主运动可能会抑制外科医生对工具的操作,降低外科医生对手术的舒适度。在这项研究中,为了研究机器人辅助眼科手术中患者安全和外科医生舒适度的参数,我们实施了三种不同的方法,旨在在协同眼睛操作任务中保持巩膜力在安全范围内。为了评估外科医生在这些过程中的舒适度,通过定义定量的舒适度指标来分析对外科医生常规操作的干扰量。前两种巩膜力控制方法基于一种自适应力控制方法,其中机器人主动抵消任何施加在巩膜上的过大力。第三种控制方法是基于虚拟夹具方法,在不安全的操作方向上为外科医生创建虚拟墙。在两名经验丰富的视网膜外科医生的用户研究中评估了所使用方法的性能,并使用定义的安全性和舒适性指标评估了手术结果。这些分析的结果表明,选择的控制范式对安全舒适的机器人辅助眼科手术结果的重要性。
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引用次数: 7
Planning High-Quality Motions for Concentric Tube Robots in Point Clouds via Parallel Sampling and Optimization. 基于并行采样和优化的同心圆管机器人点云高质量运动规划。
Alan Kuntz, Mengyu Fu, Ron Alterovitz

We present a method that plans motions for a concentric tube robot to automatically reach surgical targets inside the body while avoiding obstacles, where the patient's anatomy is represented by point clouds. Point clouds can be generated intra-operatively via endoscopic instruments, enabling the system to update obstacle representations over time as the patient anatomy changes during surgery. Our new motion planning method uses a combination of sampling-based motion planning methods and local optimization to efficiently handle point cloud data and quickly compute high quality plans. The local optimization step uses an interior point optimization method, ensuring that the computed plan is feasible and avoids obstacles at every iteration. This enables the motion planner to run in an anytime fashion, i.e., the method can be stopped at any time and the best solution found up until that point is returned. We demonstrate the method's efficacy in three anatomical scenarios, including two generated from endoscopic videos of real patient anatomy.

我们提出了一种方法来规划同心管机器人的运动,使其在避开障碍物的同时自动到达体内的手术目标,其中患者的解剖结构由点云表示。点云可以通过内窥镜仪器在术中生成,使系统能够随着患者解剖结构在手术过程中的变化而更新障碍表征。该方法将基于采样的运动规划方法与局部优化相结合,有效地处理点云数据,快速计算出高质量的运动规划。局部优化步骤采用内点优化方法,保证了每次迭代计算方案的可行性和避障性。这使得运动规划器可以随时运行,也就是说,该方法可以在任何时候停止,并且在返回该点之前找到最佳解决方案。我们在三种解剖场景中展示了该方法的有效性,其中包括两种来自真实患者解剖的内窥镜视频。
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引用次数: 11
期刊
Proceedings of the ... IEEE/RSJ International Conference on Intelligent Robots and Systems. IEEE/RSJ International Conference on Intelligent Robots and Systems
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