We introduce Trialstreamer, a living database of clinical trial reports. Here we mainly describe the evidence extraction component; this extracts from biomedical abstracts key pieces of information that clinicians need when appraising the literature, and also the relations between these. Specifically, the system extracts descriptions of trial participants, the treatments compared in each arm (the interventions), and which outcomes were measured. The system then attempts to infer which interventions were reported to work best by determining their relationship with identified trial outcome measures. In addition to summarizing individual trials, these extracted data elements allow automatic synthesis of results across many trials on the same topic. We apply the system at scale to all reports of randomized controlled trials indexed in MEDLINE, powering the automatic generation of evidence maps, which provide a global view of the efficacy of different interventions combining data from all relevant clinical trials on a topic. We make all code and models freely available alongside a demonstration of the web interface.
In clinical assessment of people with aphasia, impairment in the ability to recall and produce words for objects (anomia) is assessed using a confrontation naming task, where a target stimulus is viewed and a corresponding label is spoken by the participant. Vector space word embedding models have had inital results in assessing semantic similarity of target-production pairs in order to automate scoring of this task; however, the resulting models are also highly dependent upon training parameters. To select an optimal family of models, we fit a beta regression model to the distribution of performance metrics on a set of 2,880 grid search models and evaluate the resultant first- and second-order effects to explore how parameterization affects model performance. Comparing to SimLex-999, we show that clinical data can be used in an evaluation task with comparable optimal parameter settings as standard NLP evaluation datasets.
In this paper we describe an evaluation of the potential of classical information extraction methods to extract drug-related attributes, including adverse drug events, and compare to more recently developed neural methods. We use the 2018 N2C2 shared task data as our gold standard data set for training. We train support vector machine classifiers to detect drug and drug attribute spans, and pair these detected entities as training instances for an SVM relation classifier, with both systems using standard features. We compare to baseline neural methods that use standard contextualized embedding representations for entity and relation extraction. The SVM-based system and a neural system obtain comparable results, with the SVM system doing better on concepts and the neural system performing better on relation extraction tasks. The neural system obtains surprisingly strong results compared to the system based on years of research in developing features for information extraction.
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social communication and the presence of restricted, repetitive patterns of behaviors and interests. Prior research suggests that restricted patterns of behavior in ASD may be cross-domain phenomena that are evident in a variety of modalities. Computational studies of language in ASD provide support for the existence of an underlying dimension of restriction that emerges during a conversation. Similar evidence exists for restricted patterns of facial movement. Using tools from computational linguistics, computer vision, and information theory, this study tests whether cognitive-motor restriction can be detected across multiple behavioral domains in adults with ASD during a naturalistic conversation. Our methods identify restricted behavioral patterns, as measured by entropy in word use and mouth movement. Results suggest that adults with ASD produce significantly less diverse mouth movements and words than neurotypical adults, with an increased reliance on repeated patterns in both domains. The diversity values of the two domains are not significantly correlated, suggesting that they provide complementary information.
Emotion recognition in conversations is crucial for the development of empathetic machines. Present methods mostly ignore the role of inter-speaker dependency relations while classifying emotions in conversations. In this paper, we address recognizing utterance-level emotions in dyadic conversational videos. We propose a deep neural framework, termed conversational memory network, which leverages contextual information from the conversation history. The framework takes a multimodal approach comprising audio, visual and textual features with gated recurrent units to model past utterances of each speaker into memories. Such memories are then merged using attention-based hops to capture inter-speaker dependencies. Experiments show an accuracy improvement of 3-4% over the state of the art.
Medical professionals search the published literature by specifying the type of patients, the medical intervention(s) and the outcome measure(s) of interest. In this paper we demonstrate how features encoding syntactic patterns improve the performance of state-of-the-art sequence tagging models (both linear and neural) for information extraction of these medically relevant categories. We present an analysis of the type of patterns exploited, and the semantic space induced for these, i.e., the distributed representations learned for identified multi-token patterns. We show that these learned representations differ substantially from those of the constituent unigrams, suggesting that the patterns capture contextual information that is otherwise lost.