Mateusz Piętak, Maksymilian Sroczyński, Filip Jesionowski, Jan Stachurski
Introduction: Anaphylaxis is an acute, potentially life-threatening, systemic hypersensitivity reaction. Its prevalence in pediatric population is constantly increasing. Adrenaline is a first-line treatment in every case of anaphylaxis. Aim: To examine the details of anaphylaxis treatment in the pre-hospital setting in a pediatric population. We wanted to determine whether there is a correlation between pharmacotherapy being implemented during the Emergency Medical Services (EMS) interventions and subsequent admission to the hospital. Material and methods: In our retrospective study, we
{"title":"Details and effects of pre-hospital pharmacotherapy in pediatric population patients with anaphylactic or severe allergic symptoms – a single-center study","authors":"Mateusz Piętak, Maksymilian Sroczyński, Filip Jesionowski, Jan Stachurski","doi":"10.5114/pja.2022.116286","DOIUrl":"https://doi.org/10.5114/pja.2022.116286","url":null,"abstract":"Introduction: Anaphylaxis is an acute, potentially life-threatening, systemic hypersensitivity reaction. Its prevalence in pediatric population is constantly increasing. Adrenaline is a first-line treatment in every case of anaphylaxis. Aim: To examine the details of anaphylaxis treatment in the pre-hospital setting in a pediatric population. We wanted to determine whether there is a correlation between pharmacotherapy being implemented during the Emergency Medical Services (EMS) interventions and subsequent admission to the hospital. Material and methods: In our retrospective study, we","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70480437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostics of peanut allergy – part I","authors":"Julia Gawryjołek, A. Krogulska","doi":"10.5114/pja.2022.119228","DOIUrl":"https://doi.org/10.5114/pja.2022.119228","url":null,"abstract":"","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70481091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Publication indicates that antiviral therapies are definitely more harmful and less effective as well as less accessible than vaccinations. Antiviral therapies are generally not effective in phase II and III of the disease. The use of antiviral therapies in all patients would doom them to many side effects, and only 10% of patients go from phase I to phase II and require such treatment. The chance of curing COVID-19 patients in phase II and III of the disease is rapidly declining. Vaccinations, on the other hand, are very effective. Confirmed AEFI are rare and intensive research is underway to elucidate their etiopathogenesis. From a biotechnological point of view, vaccination leads to the production of CAR-T-like immunotherapy or monoclonal antibodies, that work from the 1st day of infection, not from the first day of symptom onset, when patients can start some pharmacological therapy. In the case of COVID-19, a clear advantage of vaccination over pharmacological therapy has emerged. Nevertheless, because vaccination may not be effective for all patients, working on therapy should also be intensively carried out. Proper pharmacotherapy administration depends on the quick cooperation of diagnosticians with doctors. It also depends on the development of tests to select therapies and determine in whom a disease such as COVID-19 will change from phase I to phase II. Vaccinated patients will probably respond better to treatments.
{"title":"Adverse effects of vaccinations and potential therapies against \u0000COVID-19","authors":"K. Wasiak, P. Rieske","doi":"10.5114/pja.2022.114392","DOIUrl":"https://doi.org/10.5114/pja.2022.114392","url":null,"abstract":"Publication indicates that antiviral therapies are definitely more harmful and less effective as well as less accessible than vaccinations. Antiviral therapies are generally not effective in phase II and III of the disease. The use of antiviral therapies in all patients would doom them to many side effects, and only 10% of patients go from phase I to phase II and require such treatment. The chance of curing COVID-19 patients in phase II and III of the disease is rapidly declining. Vaccinations, on the other hand, are very effective. Confirmed AEFI are rare and intensive research is underway to elucidate their etiopathogenesis. From a biotechnological point of view, vaccination leads to the production of CAR-T-like immunotherapy or monoclonal antibodies, that work from the 1st day of infection, not from the first day of symptom onset, when patients can start some pharmacological therapy. In the case of COVID-19, a clear advantage of vaccination over pharmacological therapy has emerged. Nevertheless, because vaccination may not be effective for all patients, working on therapy should also be intensively carried out. Proper pharmacotherapy administration depends on the quick cooperation of diagnosticians with doctors. It also depends on the development of tests to select therapies and determine in whom a disease such as COVID-19 will change from phase I to phase II. Vaccinated patients will probably respond better to treatments.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70480014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"House dust mite sensitivity in atopic children with Dectin-1 rs7309123 polymorphism","authors":"O. Mozyrska","doi":"10.5114/pja.2022.119232","DOIUrl":"https://doi.org/10.5114/pja.2022.119232","url":null,"abstract":"","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70480850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Michalak, T. Milecki, Jakub Milecki, Maciej Rembisz, K. Klimczak, Aneta Choręziak, W. Cieślikowski, A. Antczak
{"title":"Human papillomavirus (HPV) – assessing the level of knowledge, sexual behaviours, awareness, attitude, and vaccination status among dentistry students","authors":"M. Michalak, T. Milecki, Jakub Milecki, Maciej Rembisz, K. Klimczak, Aneta Choręziak, W. Cieślikowski, A. Antczak","doi":"10.5114/pja.2022.118967","DOIUrl":"https://doi.org/10.5114/pja.2022.118967","url":null,"abstract":"","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70480969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The safety of celecoxib in cutaneous hypersensitivity\u0000reactions with nonsteroidal anti-inflammatory drugs:\u0000a single-center care experience","authors":"M. Çakmak","doi":"10.5114/pja.2022.122005","DOIUrl":"https://doi.org/10.5114/pja.2022.122005","url":null,"abstract":"","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70481362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asthma is a heterogeneous disease characterized by chronic inflammation of the airways with symptoms such as wheezing, shortness of breath, chest tightness and coughing of varying frequency and severity, with varying degrees of airway obstruction. Many factors have a significant influence on the course of asthma, including smoking. The harmful effects of cigarettes have been known for a long time and pose a unique threat to people suffering from asthma. Exposure to passive inhalation of tobacco smoke and active smoking can lead to exac-erbation of the disease, wheezing, coughing and shortness of breath. Tobacco smoke irritates the respiratory system and damages the cilia. Continued exposure to cigarette smoke in the environment also increases the risk of other respiratory diseases such as bronchitis, pneumonia and lung cancer.
{"title":"Comparison of the harmfulness of smoking tobacco cigarettes versus heat-not-burn tobacco in patients with asthma","authors":"Artur Nowak, R. Pawliczak","doi":"10.5114/PJA.2021.106686","DOIUrl":"https://doi.org/10.5114/PJA.2021.106686","url":null,"abstract":"Asthma is a heterogeneous disease characterized by chronic inflammation of the airways with symptoms such as wheezing, shortness of breath, chest tightness and coughing of varying frequency and severity, with varying degrees of airway obstruction. Many factors have a significant influence on the course of asthma, including smoking. The harmful effects of cigarettes have been known for a long time and pose a unique threat to people suffering from asthma. Exposure to passive inhalation of tobacco smoke and active smoking can lead to exac-erbation of the disease, wheezing, coughing and shortness of breath. Tobacco smoke irritates the respiratory system and damages the cilia. Continued exposure to cigarette smoke in the environment also increases the risk of other respiratory diseases such as bronchitis, pneumonia and lung cancer.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70479382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
obie-cujące lub mukowiscydozie. Edycja genomu autogennych T z chimerycznym receptorem antygenowym ( chimeric antigen receptor T-cells – CAR-T). Edycja genomu w połączeniu z technologią iPSc powinna umożliwić otrzymanie tzw. uniwersalnych komórek do transplantacji, w tym uniwersalnych CAR-T. Edycja genomu jest więc szczególnie istotna kontekście immunologicznym. abStract Genome editing of induced pluripotent stem cells (iPSc) or hematopoietic tolerancji immunologicznej, ale ta zmienna jest istotna [4, 5]. Chorób warunkowanych występowaniem mutacji typu nonsens jest wiele, symptoms depend on blood cell dysfunction than, for example, in muscular dystrophy or cystic fibrosis. Genome editing is also used to refine autogenous T cells with chimeric antigen receptor T-cells (CAR-T). Finally, genome editing in combination with iPSc technology should enable the production of the so-called universal for transplantation, including universal CAR-T. Genome editing is therefore particularly important in an immunological context.
{"title":"Genome editing in therapy: immunological context","authors":"P. Rieske","doi":"10.5114/pja.2021.111801","DOIUrl":"https://doi.org/10.5114/pja.2021.111801","url":null,"abstract":"obie-cujące lub mukowiscydozie. Edycja genomu autogennych T z chimerycznym receptorem antygenowym ( chimeric antigen receptor T-cells – CAR-T). Edycja genomu w połączeniu z technologią iPSc powinna umożliwić otrzymanie tzw. uniwersalnych komórek do transplantacji, w tym uniwersalnych CAR-T. Edycja genomu jest więc szczególnie istotna kontekście immunologicznym. abStract Genome editing of induced pluripotent stem cells (iPSc) or hematopoietic tolerancji immunologicznej, ale ta zmienna jest istotna [4, 5]. Chorób warunkowanych występowaniem mutacji typu nonsens jest wiele, symptoms depend on blood cell dysfunction than, for example, in muscular dystrophy or cystic fibrosis. Genome editing is also used to refine autogenous T cells with chimeric antigen receptor T-cells (CAR-T). Finally, genome editing in combination with iPSc technology should enable the production of the so-called universal for transplantation, including universal CAR-T. Genome editing is therefore particularly important in an immunological context.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70479704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ewelina Kasprzyk-Wieczorkowska, Edyta Jura-Szołtys, Olga Branicka, R. Gawlik
Treatment of haemorrhoidal disease is very often based on the local application of suppositories or creams. These preparations are widespread and often available over the counter. Most of the measures it contains several active ingredients, including painkillers, vasoprotectors or local anesthetics. In some cases, combined treatment is used. Drug hypersensitivity reaction is best understood and described for immediate reactions occurring mainly after the use of antibiotics, non-steroidal anti-inflammatory drugs or local anesthetics. This article highlights the importance of substances with rare describe hypersensitivity reactions. A case of patient with hypersensitivity to Procto-Glyvenol, a drug contain tribenoside and lignocaine. In the diagnostic process emphasizes the use of epidermal patch testing as an essential test in response to topical agents and in reactions delayed. Drug hypersensitivity reactions to tribenoside are very little known and rarely reported.
{"title":"Hypersensitivity reaction after Procto-Glyvenol application","authors":"Ewelina Kasprzyk-Wieczorkowska, Edyta Jura-Szołtys, Olga Branicka, R. Gawlik","doi":"10.5114/PJA.2021.109383","DOIUrl":"https://doi.org/10.5114/PJA.2021.109383","url":null,"abstract":"Treatment of haemorrhoidal disease is very often based on the local application of suppositories or creams. These preparations are widespread and often available over the counter. Most of the measures it contains several active ingredients, including painkillers, vasoprotectors or local anesthetics. In some cases, combined treatment is used. Drug hypersensitivity reaction is best understood and described for immediate reactions occurring mainly after the use of antibiotics, non-steroidal anti-inflammatory drugs or local anesthetics. This article highlights the importance of substances with rare describe hypersensitivity reactions. A case of patient with hypersensitivity to Procto-Glyvenol, a drug contain tribenoside and lignocaine. In the diagnostic process emphasizes the use of epidermal patch testing as an essential test in response to topical agents and in reactions delayed. Drug hypersensitivity reactions to tribenoside are very little known and rarely reported.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70479745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Klaudia Waszczykowska, Marta Węgierska, Roxana Drygała, R. Pawliczak
Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) significantly affect the patient's respiratory system, which requires individualised treatment and professional control During the SARS-CoV-2 pandemic, all respiratory diseases were taken into consideration as risk factors for severe COVID-19 ACE2 and TMPRSS2 genes, which are crucial for SARS-CoV-2 to enter the host cell, have different expression in the occurrence of asthma or COPD Also, comparing the severity and mortality of patients with coexistence of asthma or COPD and COVID-19, only COPD patients had worse outcomes of COVID-19, and their mortality was significantly higher Although ACOS is also a potential risk factor for hospitalisation and mortality in COVID-19 patients, the condition still requires further studies This overview presents the current state of knowledge on the relationship between the diseases mentioned above and COVID-19
{"title":"Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome and the risk of severe COVID-19","authors":"Klaudia Waszczykowska, Marta Węgierska, Roxana Drygała, R. Pawliczak","doi":"10.5114/PJA.2021.104655","DOIUrl":"https://doi.org/10.5114/PJA.2021.104655","url":null,"abstract":"Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) significantly affect the patient's respiratory system, which requires individualised treatment and professional control During the SARS-CoV-2 pandemic, all respiratory diseases were taken into consideration as risk factors for severe COVID-19 ACE2 and TMPRSS2 genes, which are crucial for SARS-CoV-2 to enter the host cell, have different expression in the occurrence of asthma or COPD Also, comparing the severity and mortality of patients with coexistence of asthma or COPD and COVID-19, only COPD patients had worse outcomes of COVID-19, and their mortality was significantly higher Although ACOS is also a potential risk factor for hospitalisation and mortality in COVID-19 patients, the condition still requires further studies This overview presents the current state of knowledge on the relationship between the diseases mentioned above and COVID-19","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70478643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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