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Psychological and social effects on long term quarantined college students: Prevalence, correlated factors and coping skills 长期隔离大学生的心理和社会影响:患病率、相关因素和应对技能
Pub Date : 2025-01-01 DOI: 10.1016/j.rcpeng.2023.10.003
Héctor Badellino , María Emilia Gobbo , Eduardo Torres , María Emilia Aschieri , Martín Biotti , Valentina Alvarez , Camila Gigante , Mabel Cachiarelli

Objectives

To determine the prevalence of anxiety, depression and stress on Argentinian university students, their risk factors, concerns and coping skills.

Method

A cross-sectional study was conducted in college students from Argentina, using a survey spread on social networks.

Results

Of 1711 surveyed students, 40.67% experienced moderate/severe anxiety, 58.03% experienced moderate/severe depression, 48.01% experienced stress and 68.8% reported insomnia. Females (aOR: 2.14; 95% CI: 1.67–2.75), young people (aOR: 2.86; 95%CI: 1.07–7.65), smokers (aOR: 1.34; 95% CI: 1.005–1.79), users of marijuana (aOR: 2.17; 95% CI: 1.19–3.96) and participants with poor sleep quality (aOR: 3.99; 95% CI: 3.08–5.17) were more affected. Economic concerns (aOR: 2.95; 95% CI: 1.50–2.68), unemployment (aOR: 1.55; 95% CI: 1.02–1.56) and concern about not seeing friends (aOR: 1.27; 95% CI: 1.03–1.56) were associated with increased risk of having the conditions mentioned above.

Conclusions

The psychological impact caused by the long-term confinement is greater on Argentinian university students than on the general population.
目的了解阿根廷大学生焦虑、抑郁和压力的患病率及其危险因素、担忧和应对技能。方法采用在社交网络上传播的调查方法,对阿根廷大学生进行横断面研究。结果在1711名受访学生中,40.67%的人有中度/重度焦虑,58.03%的人有中度/重度抑郁,48.01%的人有压力,68.8%的人有失眠。女性(aOR: 2.14;95% CI: 1.67-2.75),年轻人(aOR: 2.86;95%CI: 1.07-7.65),吸烟者(aOR: 1.34;95% CI: 1.005-1.79),大麻使用者(aOR: 2.17;95% CI: 1.19-3.96)和睡眠质量差的参与者(aOR: 3.99;95% CI: 3.08-5.17)。经济问题(aOR: 2.95;95% CI: 1.50-2.68),失业率(aOR: 1.55;95% CI: 1.02-1.56)和担心见不到朋友(aOR: 1.27;95% CI: 1.03-1.56)与患上述疾病的风险增加有关。结论长期禁闭对阿根廷大学生的心理影响大于对普通人群的心理影响。
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引用次数: 0
Catatonia and Cotard's Syndrome in a Patient With Systemic Lupus Erythematosus: A Case Report 系统性红斑狼疮患者紧张症和科塔尔综合征1例报告
Pub Date : 2025-01-01 DOI: 10.1016/j.rcpeng.2025.07.003
Claudia Elera-Fitzcarrald , Jeff Huarcaya-Victoria , Guilliam Beltrán

Introduction

Systemic lupus erythematosus (SLE) is an autoimmune disease with multiorgan involvement, being the development of neuropsychiatric (NP) symptoms variable, in which the presentation of catatonia and Cotard syndrome (CoS) is rare.

Case presentation

We report the case of a 29-year-old woman who was diagnosed with SLE in 2018 based on the presence of articular, serosal and, hematological manifestations and immunological abnormalities. During her hospitalization, inappropriate behaviors including repetitive and incoherent speech, visual and olfactory hallucinations developed, so NP involvement was considered, and quetiapine and methylprednisolone pulses were administered with good response. The patient was discharged to the care of her family, being stuporous, bradypsychic, with thought blockages and nihilistic delusions; in consequence, she was diagnosed with Cotard syndrome (CoS). Moreover, she presented symptoms of catatonia including mutism, catalepsy and rigidity. Treatment consisted of diazepam, aripiprazole 30 mg/day, fluoxetine 20 mg/day and prednisone 60 mg/day.

Conclusion

Catatonia can be a manifestation of NPSLE in active SLE. Catatonic symptoms and CoS in NPSLE have never been described. This is the first report of a SLE patient exhibiting CoS and catatonia.
系统性红斑狼疮(SLE)是一种累及多器官的自身免疫性疾病,其神经精神(NP)症状的发展是可变的,其中紧张症和科塔尔综合征(CoS)的表现是罕见的。我们报告了一例29岁的女性,她在2018年被诊断为SLE,基于关节、血液学和血液学表现以及免疫异常。住院期间出现言语重复不连贯、视、嗅觉幻觉等不当行为,考虑NP累及,给予喹硫平、甲基强的松龙脉冲治疗,效果良好。病人出院后由她的家人照顾,神志不清,迟钝,有思想障碍和虚无主义妄想;结果,她被诊断出患有科塔尔综合征(CoS)。此外,她还表现出紧张症的症状,包括沉默、抽搐和僵硬。治疗包括地西泮、阿立哌唑30毫克/天、氟西汀20毫克/天和强的松60毫克/天。结论紧张症可能是SLE活动期NPSLE的一种表现。NPSLE的紧张性症状和CoS从未被描述过。这是首次报告SLE患者表现出CoS和紧张症。
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引用次数: 0
Cerebellar Cognitive-Affective Syndrome: A Case Report and Review of Literature 小脑认知-情感综合征1例报告及文献复习
Pub Date : 2025-01-01 DOI: 10.1016/j.rcpeng.2022.11.003
Olivia Olivé-Arias, Dania Falfán-Salgado, Carlos De la Cruz-de la Cruz, Omar Kawas-Valle

Introduction

The cerebellum has traditionally been found to be the only coordinator of motor functions, however, recent studies have shown that the cerebellum also has a role in cognitive and affective processing. CCAS is characterized by impaired executive functions, visual–spatial disorganization, emotional dysregulation, changes in personality and language deficits. The cognitive and affective symptoms that make up the CCAS have been attributed to disorders of the cerebral hemispheres, specifically in association areas and paralimbic regions.

Case report

A 26-year-old woman is presented, with a history of sexual abuse at the age of 14, a history of psychiatric hospitalizations due to multiple depressive episodes and suicide attempts since the age of 16, who also presents a deficiency in information processing speed and visual–spatial disorganization. CMR is performed showing evidence of cerebellar cortex atrophy.

Discussion/conclusion

Early identification and diagnosis of CCAS is vital for effective therapy and perhaps better outcomes. Faced with a profile with cognitive-affective symptoms, neuropsychological deficits, and language disorders, CCAS should be included in the differential diagnosis, and physicians should intentionally look for cerebellar lesions.
小脑一直被认为是运动功能的唯一协调者,然而,最近的研究表明,小脑也在认知和情感处理中发挥作用。CCAS的特点是执行功能受损、视觉空间紊乱、情绪失调、人格改变和语言缺陷。构成CCAS的认知和情感症状被归因于大脑半球的紊乱,特别是在关联区和旁边缘区。病例报告:一名26岁的女性,14岁时有性虐待史,16岁以来因多次抑郁发作和自杀未遂而住院治疗,同时还表现出信息处理速度和视觉空间混乱的缺陷。CMR显示小脑皮质萎缩的证据。讨论/结论早期识别和诊断CCAS对于有效的治疗和更好的结果至关重要。面对认知情感症状、神经心理缺陷和语言障碍,CCAS应纳入鉴别诊断,医生应有意识地寻找小脑病变。
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引用次数: 0
Creation and Validation of an Educational Booklet on Autism Spectrum Disorder 自闭症谱系障碍教育小册子的制作与验证。
Pub Date : 2024-10-01 DOI: 10.1016/j.rcpeng.2022.09.001
Marciana Fernandes Moll , Carla Aparecida Arena Ventura , Aldo Matos , Ana Beatriz Rizzo Zanardo , Mary Carla Velasco Melo , Ronadia dos Santos Silva

Objectives

To develop and validate an educational booklet that contributes to alleviating the difficulties experienced by family members of children diagnosed as being on the Autism Spectrum.

Methods

A descriptive exploratory study with a quali-quantitative approach. Ten families of children on the autism spectrum and twelve judges participated in the validation. Data collection took place through open interviews and data was analysed according to the procedures recommended by Bardin.

Results

Difficulties identified included problems in children's verbal and non-verbal communication, daily care, school inclusion, late diagnosis due to the lack of specialists, and lack of psychological support for the family and for handling the child during an episode of crisis. Informational needs included early diagnosis, evolution and management of crises, children's ability to learn daily life activities, and information about their right to inclusion in formal education. Based on these difficulties and needs, the booklet was created and validated by eight experts and four family members. Comparing the average of positive reviews in each section, which were obtained in the first and second evaluations, there was a general improvement in the quality of the booklet.

Conclusions

The validation of educational materials on this topic can be essential to improve the quality of life of children, families, and educators.
目的:开发和验证一个教育小册子,有助于减轻诊断为自闭症谱系儿童的家庭成员所经历的困难。方法:采用定性定量方法进行描述性探索性研究。10个自闭症儿童家庭和12位评委参与了验证。通过公开访谈收集数据,并根据Bardin建议的程序对数据进行分析。结果:发现的困难包括儿童的语言和非语言交流、日常护理、学校融入、由于缺乏专家而延迟诊断、缺乏对家庭的心理支持和在危机事件中处理儿童的支持。信息需求包括早期诊断、危机演变和管理、儿童学习日常生活活动的能力,以及关于儿童接受正规教育的权利的信息。基于这些困难和需求,这本小册子是由8位专家和4位家庭成员创建并验证的。比较在第一次和第二次评价中获得的每一节的平均好评,小册子的质量普遍有所改善。结论:对这一主题的教育材料的验证对于改善儿童、家庭和教育者的生活质量至关重要。
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引用次数: 0
Exploring Stigma Towards People with Schizophrenia in Mass Media and Their Private Discourses 探讨大众传媒对精神分裂症患者的污名及其私人话语。
Pub Date : 2024-10-01 DOI: 10.1016/j.rcpeng.2024.12.004
Emmanuel Méndez , Alicia Figueroa-Barra , Cristina Martínez , Eduardo Durán

Introduction

It has been shown that public stigma towards people with schizophrenia hinders their psychosocial integration. Public stigma expresses itself through lexical labels used in the print media and social networks, heightening the internalization of stigma in this population, a phenomenon known as internalised stigma or self-stigma. This paper analyses the diffusion in the mass media of two dimensions of stigma: public stigma and self-stigma.

Methods

For public stigma, we searched for the lexical labels “schizophrenia”, “schizophrenic”, “psychosis” and “psychotic” in Chilean newspapers from 2010 to 2020, and for self-stigma, we used semi-structured interviews with people with a diagnosis of schizophrenia who are users of mental health services in Santiago de Chile. The findings were organised into four categories per stigma dimension. Lexical frequencies and semantic relationships were then analysed using the UAM Corpus tool and AntConc software.

Results

The results showed frequent use of stigmatising labels in the written press, with harmful semantic associations such as violence, delinquency, unpredictability and danger.

Conclusions

Such labels tend to be accepted by those affected, evidence of their internalisation of the stigma towards the disease, and create a barrier to integration and inclusion.
导言:研究表明,公众对精神分裂症患者的成见阻碍了他们融入社会心理。公众成见通过印刷媒体和社交网络中使用的词汇标签表现出来,加剧了该人群成见的内化,这种现象被称为内化成见或自我成见。本文分析了成见在大众媒体中的两个方面的传播:公众成见和自我成见:在公众污名方面,我们搜索了 2010 年至 2020 年智利报纸上的 "精神分裂症"、"精神分裂症患者"、"精神病 "和 "精神病患者 "等词条;在自我污名方面,我们对智利圣地亚哥精神卫生服务机构的精神分裂症患者进行了半结构式访谈。调查结果按成见维度分为四个类别。然后使用 UAM 语料库工具和 AntConc 软件对词频和语义关系进行分析:结果:研究结果表明,在书面报刊中经常使用污名化标签,这些标签与暴力、犯罪、不可预测性和危险等有害语义相关联:结论:这些标签往往被患者所接受,证明了他们对疾病的成见已经内化,并对融入和包容造成了障碍。
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引用次数: 0
Relationship Between Chronic Obstructive Pulmonary Disease Exacerbations and Depression 慢性阻塞性肺疾病加重与抑郁的关系
Pub Date : 2024-10-01 DOI: 10.1016/j.rcpeng.2024.12.002
Pablo Salomón Montes-Arcón , Adalberto Campo-Arias , John Carlos Pedrozo-Pupo

Background and objectives

Depressive episodes are frequent in chronic obstructive pulmonary disease (COPD) patients. These episodes are related to a vast number of clinical and psychosocial variables. Nevertheless, the relationship between the number of COPD exacerbations and depression has not been extensively studied in the Colombian Caribbean. The objective was to determine the relationship between COPD exacerbations and depression in a sample of outpatients in Santa Marta, Colombia.

Methods

A cross-sectional analytical study was designed in which COPD adult patients participated. The number of COPD exacerbations (none versus one or more) and the risk of depression were documented. The crude and adjusted association was established by calculating the odds ratios (OR) and 95% confidence interval (95%CI).

Results

The study included 408 patients aged between 40 and 102 years (mean 72.9 ± 10.2), and 58.8% were male. 105 patients (25.9%) reported one or more exacerbations in COPD, and 114 patients (27.9%) were at risk for depression. The crude relationship between exacerbations and depression was statistically significant (OR = 1.80; 95%CI, 1.12-2.89) and after adjusting for sex (OR = 1.99; 95%CI, 1.23-3.23).

Conclusions

The number of COPD exacerbations among outpatients in Santa Marta, Colombia is related to depression. Longitudinal studies are needed in Colombia.
背景与目的:抑郁发作在慢性阻塞性肺疾病(COPD)患者中很常见。这些发作与大量临床和社会心理变量有关。然而,在哥伦比亚加勒比地区,COPD恶化与抑郁症之间的关系尚未得到广泛研究。目的是在哥伦比亚圣玛尔塔的门诊病人样本中确定COPD恶化和抑郁之间的关系。方法:设计一项COPD成人患者参与的横断面分析研究。记录了COPD加重的次数(无加重对一次或多次加重)和抑郁的风险。通过计算比值比(OR)和95%置信区间(95% ci)建立粗相关性和校正相关性。结果:纳入408例患者,年龄40 ~ 102岁,平均72.9±10.2岁,其中58.8%为男性。105名患者(25.9%)报告了一次或多次COPD加重,114名患者(27.9%)有抑郁风险。加重与抑郁之间的粗略关系有统计学意义(OR=1.80;95%CI, 1.12-2.89)和调整性别后(OR=1.99;95%可信区间,1.23 - -3.23)。结论:哥伦比亚圣玛尔塔门诊患者COPD加重次数与抑郁症有关。哥伦比亚需要进行纵向研究。
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引用次数: 0
Structural Study of Anxiety and Mood-related Symptomatology in Psychiatric Outpatients 精神病门诊患者焦虑和情绪相关症状的结构研究。
Pub Date : 2024-10-01 DOI: 10.1016/j.rcpeng.2024.12.005
Johann M. Vega-Dienstmaier , Frine Samalvides , Renato D. Alarcón

Introduction

Knowledge of the symptomatological structure of mental disorders is relevant for their understanding and classification. In the absence of previous Latin American research on the simultaneous structural exploration of various types of psychiatric symptomatologies, the objective of this study is to examine the structure of anxious and mood-related symptoms, resulting syndromes, and their correlations.

Method

Several instruments for the evaluation of anxious, depressive, and manic symptoms were administered to 305 psychiatric outpatients. Using factor analysis and network graphs based on polychoric correlations between the symptoms, their clustering patterns (syndromes) were explored. Further, correlations between the scores of each resulting syndrome were performed.

Results

The symptom grouping process led to a total of fifteen generally overlapping syndromes: fear of evaluation, fear of people, agoraphobia, general anxiety, somatization, anergy, depressive core, lack of positive mood, cognitive difficulties, mania, post-traumatic stress/obsessions, fear of madness/loss of control, acrophobia, irritability, and sleep disturbances. General anxiety was at the center of the structure. Morning/matinal pole, hypersomnia, and increased appetite were relatively isolated symptoms.

Conclusion

Overlapping and/or highly correlated psychiatric syndromes were prominent findings, underlining the pertinence of a dimensional approach as a substantial strategy toward a more inclusive understanding of mental disorders.
前言:了解精神障碍的症状学结构有助于对其进行理解和分类。由于缺乏以往拉丁美洲对各种类型精神症状的同时结构探索的研究,本研究的目的是检查焦虑和情绪相关症状的结构,由此产生的综合征,以及它们之间的相关性。方法:对305例精神科门诊患者进行焦虑、抑郁和躁狂症状评估。利用因子分析和基于症状之间多重相关性的网络图,探索其聚类模式(证候)。此外,还进行了每种综合征评分之间的相关性分析。结果:症状分组过程共产生15个大致重叠的症状:害怕评价、害怕人、广场恐怖、一般焦虑、躯体化、能量、抑郁核心、缺乏积极情绪、认知困难、躁狂、创伤后应激/困扰、害怕疯狂/失去控制、恐高、易怒、睡眠障碍。普遍的焦虑是这个结构的中心。早/午极、嗜睡和食欲增加是相对孤立的症状。结论:重叠和/或高度相关的精神综合征是突出的发现,强调了维度方法作为对精神障碍更具包容性理解的实质性策略的相关性。
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引用次数: 0
Subcultural Representations of Perpetrators and Victims of Crime and Violence Associated with Mental Disorders 与精神障碍相关的犯罪和暴力的肇事者和受害者的亚文化表征。
Pub Date : 2024-10-01 DOI: 10.1016/j.rcpeng.2024.12.003
Fabian Pavez , Erika Saura , Pedro Marset

Introduction and objectives

The beliefs and opinions of the general population are based substantially on mass media, which often equates mental disorders with violence and criminality. These stigmatising depictions contribute to the development and persistence of negative attitudes towards people with psychiatric conditions. The objective was to examine, through popular music, the subcultural representations of crime and violence in the context of mental disorders, focusing on depictions of victims and offenders.

Methods

Strategy of analysis: Content analysis of Spanish punk lyrics (1981-2010) with references to violent and criminal behaviour associated with mental disorders.

Results

257 Spanish punk bands were identified. The discographies included 7,777 songs, of which 190 were related to aggression, violence, or crime. A predilection for violent crimes and descriptions of the perpetrator as “mentally disturbed” was observed. Although they were present, psychotic symptoms were not the main psychiatric symptoms associated with violent crime, but instead it was substance use, antisocial personality traits and paraphilic behaviour. There was less attention paid to victims than to perpetrators.

Conclusions

The relationships between mental disorders and criminality/violence are overemphasised in the analysed subculture. A positive connotation of social deviance and violent content (particularly serial murder) in service to the provocative nature of this type of music was observed.
引言和目标:一般民众的信仰和意见主要基于大众传媒,而大众传媒往往将精神障碍与暴力和犯罪等同起来。这些污名化的描述助长了对精神疾病患者的消极态度的发展和持续。目的是通过流行音乐,审查在精神障碍背景下犯罪和暴力的亚文化表现形式,重点是对受害者和罪犯的描绘。方法:分析策略:西班牙朋克歌词(1981-2010)的内容分析,参考与精神障碍相关的暴力和犯罪行为。结果:共识别出257支西班牙朋克乐队。这些唱片包括7777首歌曲,其中190首与侵略、暴力或犯罪有关。我们观察到人们对暴力犯罪的偏爱,并将犯罪者描述为“精神失常”。虽然存在精神病症状,但它们并不是与暴力犯罪相关的主要精神病症状,而是药物使用、反社会人格特征和性反常行为。对受害者的关注少于对肇事者的关注。结论:在分析的亚文化中,精神障碍与犯罪/暴力之间的关系被过分强调。社会偏差和暴力内容(特别是连环谋杀)的积极内涵服务于这种类型的音乐的挑衅性被观察到。
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引用次数: 0
Cultural Beliefs About the Etiology of Schizophrenia and Expressed Emotion in Mexican Families 墨西哥家庭精神分裂症病因与情绪表达的文化信仰。
Pub Date : 2024-10-01 DOI: 10.1016/j.rcpeng.2024.12.001
Ricardo Ignacio Audiffred-Jaramillo , Javier Eduardo García De Alba-García

Introduction

Schizophrenia is a severe and persistent mental disorder that affects around 21 million people worldwide. The etiology of schizophrenia is currently understood as heterogeneous and multifactorial. Genetic and environmental factors are the most common explanations for the onset of schizophrenia, but along with these, hybridized cultural ideas coexist between medical, superstitious, and religious paradigms. The objective was to identify the relationship between cultural beliefs about schizophrenia, etiology and expressed emotion.

Methods

The present study used a mixed-method design, with an analytical approach for ethnographic research. The sample consisted of 40 people, relatives of patients diagnosed with schizophrenia, selected using simple random probabilistic sampling.

Results

A valid cultural consensus was found with statistical significance (p≤.05). Emotional trauma in childhood was identified as the leading cause of schizophrenia, followed by hereditary factors, emotional problems, head trauma, mistreatment, and divine will. The better-informed relatives expressed less emotion than those with less cultural competence (Mann-Whitney's U = 1.000; p < .001).

Conclusions

Mexican families in this study had a high degree of scientific knowledge about the etiology of schizophrenia, but religious ideas and compassionate explanations were part of this hybridized model.
导言精神分裂症是一种严重而顽固的精神障碍,全球约有 2 100 万人患有此病。精神分裂症的病因目前被认为是多种多样的。遗传和环境因素是精神分裂症发病的最常见解释,但与此同时,医学、迷信和宗教范式之间也存在着杂交的文化观念。本研究旨在确定精神分裂症的文化信仰、病因和情感表达之间的关系:本研究采用了混合方法设计,并采用了人种学研究的分析方法。样本由 40 人组成,他们都是被诊断为精神分裂症患者的亲属,采用简单随机概率抽样法选出:结果:发现了一种有效的文化共识,且具有统计学意义(p≤.05)。童年时期的情感创伤被认为是导致精神分裂症的主要原因,其次是遗传因素、情感问题、头部创伤、虐待和神意。与文化素养较低的亲属相比,文化素养较高的亲属表达的情感较少(Mann-Whitney's U=1.000; p结论:本研究中的墨西哥家庭对精神分裂症的病因有较多的科学知识,但宗教观念和同情的解释也是这种混合模式的一部分。
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引用次数: 0
Effectiveness of Paliperidone Palmitate on Treatment Adherence and Relapse in the Adult Schizophrenia Population: A One-Year Mirror-Image Study in a Colombian Mental Health Care Facility 棕榈酸帕利哌酮对成年精神分裂症患者治疗依从性和复发的影响:哥伦比亚精神卫生保健机构为期一年的镜像研究
Pub Date : 2024-10-01 DOI: 10.1016/j.rcpeng.2022.06.006
Oscar Ribero , Anne-Marie Castilloux , Lina Maria Agudelo , Gerardo Machnicki , Vanesa Morales , Sergio Perocco , Genaro Castillon , Yola Moride

Introduction

The benefits of long-acting injectable antipsychotics have been documented in several observational studies, but data remain scarce in Latin America. This study aimed at evaluating the effectiveness of paliperidone palmitate once monthly (PP1M) on treatment adherence and relapse in the schizophrenia population followed in a government-funded mental health care facility in Colombia.

Methods

A mirror-image study was conducted. Adult schizophrenia patients treated with oral antipsychotics who subsequently received ≥2 PP1M injections between Jan. 1st, 2015 and Oct. 31st, 2018 were included. The study consisted of two retrospective phases: 12 months before and after the first PP1M injection. Outcomes were treatment adherence (proportion of days covered ≥80%), hospitalized relapse, hospital length of stay, and non-hospitalised relapse. Effect of PP1M on outcomes was assessed through multivariable conditional Poisson regression.

Results

123 patients were eligible (mean age, 30.3 years; 79.7% males). Adherence was 23.6% in the pre-phase and 89.4% in the post-phase (RR = 3.77; 95%CI, 2.75-5.17). The proportion of patients with hospitalised relapse decreased from 46.3% to 35.0% (RR = 0.76; 95%CI, 0.59-0.99). In the 75 (61.0%) patients who continued PP1M throughout post-phase, beneficial effect on hospitalised relapse was stronger (RR = 0.64; 95%CI, 0.42-0.98). The proportion of patients with non-hospitalised relapse symptoms increased from 6.5% to 18.7% (RR = 2.27; 95%CI, 1.11-4.64).

Conclusions

PP1M initiation led to a dramatic improvement in treatment adherence and a decrease in hospitalised relapse. Observed increase in non-hospitalised relapse may be explained by a decrease in severity. Limitations are absence of a parallel comparison group and a generalisability limited to the population treated at this facility. Study provides data for the Latin America region and strength is the assessment of non-hospitalised relapse symptoms.
几项观察性研究证实了长效注射抗精神病药物的益处,但拉丁美洲的数据仍然很少。本研究旨在评估每月一次棕榈酸帕利哌酮(PP1M)对在哥伦比亚政府资助的精神卫生保健机构随访的精神分裂症患者治疗依从性和复发的有效性。方法:采用镜像研究。纳入2015年1月1日至2018年10月31日期间接受口服抗精神病药物治疗并随后接受≥2次PP1M注射的成人精神分裂症患者。该研究包括两个回顾性阶段:第一次PP1M注射前后12个月。结果为治疗依从性(覆盖天数比例≥80%)、住院复发、住院时间和非住院复发。通过多变量条件泊松回归评估PP1M对预后的影响。结果:123例患者符合条件(平均年龄30.3岁;79.7%的男性)。依从性在前期为23.6%,在后期为89.4% (RR=3.77;95%可信区间,2.75 - -5.17)。住院复发患者比例由46.3%降至35.0% (RR=0.76;95%可信区间,0.59 - -0.99)。在75例(61.0%)患者在整个后期持续PP1M中,对住院复发的有益作用更强(RR=0.64;95%可信区间,0.42 - -0.98)。出现未住院复发症状的患者比例从6.5%上升至18.7% (RR=2.27;95%可信区间,1.11 - -4.64)。结论:PP1M起始治疗显著改善了治疗依从性,降低了住院复发率。观察到的非住院复发的增加可以用严重程度的降低来解释。限制是缺乏平行的比较组和仅限于在该设施治疗的人群的普遍性。该研究为拉丁美洲地区提供了数据,其优势在于对非住院复发症状的评估。
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Revista Colombiana de psiquiatria (English ed.)
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