Alzheimer's & Dementia最新文献

{"title":"An unsupervised learning approach for clustering joint trajectories of Alzheimer's disease biomarkers: An application to ADNI Data","authors":"Teresa Filshtein Sönmez, Danielle J. Harvey, Laurel A. Beckett","doi":"10.1002/alz.14524","DOIUrl":"https://doi.org/10.1002/alz.14524","url":null,"abstract":"Current models of Alzheimer's disease (AD) progression assume a common pattern and pathology, oversimplifying the heterogeneity of clinical AD.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"23 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease","authors":"Boye Wen, Xiaodong Han, Jin Gong, Pin Wang, Wenxian Sun, Chang Xu, Aidi Shan, Xin Wang, Heya Luan, Shaoqi Li, Ruina Li, Jinxuan Guo, Runqi Chen, Chuqiao Li, Yao Sun, Sirong Lv, Cuibai Wei","doi":"10.1002/alz.14547","DOIUrl":"https://doi.org/10.1002/alz.14547","url":null,"abstract":"Alzheimer's disease (AD) is a degenerative disease characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence and progression of AD pathology has been well documented. Poor nutritional status accelerates AD progress by potentially aggravating amyloid beta (Aβ) and tau deposition, exacerbating oxidative stress response, modulating the microbiota–gut–brain axis, and disrupting blood–brain barrier function. The advanced stage of AD tends to lead to malnutrition due to cognitive impairments, sensory dysfunctions, brain atrophy, and behavioral and psychological symptoms of dementia (BPSD). This, in turn, produces a vicious cycle between malnutrition and AD. This review discusses how nutritional factors and AD deteriorate each other from the early stage of AD to the terminal stages of AD, focusing on the potential of different levels of nutritional factors, ranging from micronutrients to diet patterns. This review provides novel insights into reducing the risk of AD, delaying its progression, and improving prognosis.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"34 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in multimorbidity and cognitive function studies: A call for rigorous analysis and reporting","authors":"Xiaozhi Chen, Zhiqiang Zhang","doi":"10.1002/alz.14391","DOIUrl":"https://doi.org/10.1002/alz.14391","url":null,"abstract":"<p>This letter is in response to “Multimorbidity measures associated with cognitive function among community-dwelling older Chinese adults” by Wang and colleagues.<span>¹</span></p>\u0000<p>In their article, Wang et al. explored, using longitudinal survey data, the association of multimorbidity with cognitive function among older Chinese adults. We write to highlight key points for further exploration. First, exploratory factor analysis was used to examine the relationship among the 14 individual chronic conditions, but the Kaiser–Meyer–Olkin value of 0.67 can only indicate a mediocre pattern of correlations.<span>²</span> Addtionally, more than half of the factor loading were below 0.5, which is considerded as a threshold value with practical significance.</p>\u0000<p>As the authors note, most of these conditions were self-reported by participants except for components of sensory pattern; this may weaken the correlation between other patterns and cognitive function and likely explain the strongest association with cognitive function among sensory pattern both at baseline and the first follow-up; only sensory pattern showed similar results in both sexes compared with the total population may also be attributed to this. Similarly, participants with more chronic conditions were more likely to live in urban areas, possible explanation is that urban areas have relatively abundant medical resources compared to rural areas. These information biases caused by different disease detection rates may lead to a deviation from reality.<span>³</span></p>\u0000<p>Lack of death information is another issue. Although the study is still ongoing, the mortality data in a longitudinal study can be gradually updated during the follow-up period and analyzed based on existing data. Completely ignoring the impact of mortality may lead to bias in the risk assessment of cognitive decline, especially in the elderly population where mortality is a very common and significant competitive risk. Besides, the proportion of participants with the three multimorbidity patterns was not provided in the article, which directly affects the explanatory power of statistical analysis.<span>⁴</span></p>\u0000<p>Overall, this study provided interesting information on the multimorbidity measures and their association with cognitive performance in Chinese community-dwelling older adults. Nonetheless, imperfect exploratory factor analysis, information bias, and incomplete reporting impact its reliability and validity.</p>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"36 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current practices by Alzheimer's Disease Research Centers to remunerate research participants","authors":"Matthew Gabel, Semere Bekena, Mitch O'Meara, Andrea Denny, Erin D. Solomon, Krista L. Moulder, John C. Morris, Jessica Mozersky","doi":"10.1002/alz.14542","DOIUrl":"https://doi.org/10.1002/alz.14542","url":null,"abstract":"Recent guidance from the National Alzheimer's Coordinating Center (NACC) recommends remuneration for all Alzheimer's disease (AD) research participants. Given AD research recruitment challenges, we assessed the remuneration practices at Alzheimer's Disease Research Centers (ADRCs).","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"84 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoiding causal fraud in the evaluation of clinical benefits of treatments for Alzheimer's disease","authors":"Kathy Y. Liu, Stephen Senn, Robert Howard","doi":"10.1002/alz.14457","DOIUrl":"https://doi.org/10.1002/alz.14457","url":null,"abstract":"Recent regulatory approvals of three amyloid-lowering monoclonal antibody therapies for the treatment of Alzheimer's disease (AD) have triggered a polarizing debate in the field on the clinical meaningfulness of their reported effects. The question of how to define clinical meaningfulness for any treatment that has a modest effect size is important and will likely be subject to influence from interested stakeholders. We warn of claims of evaluating meaningful within-individual change from randomized parallel-group trials of AD treatments, sometimes purportedly assessed by a commonly recognized “responder” analysis approach, and explain why it is likely to mislead and should simply be avoided. The average between-group difference in score change is where the debate and research efforts should be focused to contextualize and evaluate the clinical meaningfulness of the true treatment effect. The statistical and communication principles we consider and would recommend are applicable to the evaluation of most interventions in medicine.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"22 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Offspring education and cognitive health: A comparison between Hispanic and White older adults in the United States","authors":"Erika Meza, Karla Renata Flores Romero, Isabel E. Allen, Hector M. González, M. Maria Glymour, Jacqueline M. Torres","doi":"10.1002/alz.14523","DOIUrl":"https://doi.org/10.1002/alz.14523","url":null,"abstract":"We compared the relationship between offspring education and cognitive health outcomes among Hispanic and White adults.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"48 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-cohort study of longitudinal and cross-sectional Alzheimer's disease biomarkers in cognitively unimpaired older adults","authors":"Long Xie, Sandhitsu R. Das, Yue Li, Laura E. M. Wisse, Emily McGrew, Xueying Lyu, Michael DiCalogero, Ujashi Shah, Ademola Ilesanmi, Amanda E. Denning, Chris A. Brown, Jesse Cohen, Lasya Sreepada, Mengjin Dong, Niyousha Sadeghpour, Pulkit Khandelwal, Ranjit Ittyerah, Sadhana Ravikumar, Shokufeh Sadaghiani, Stanislau Hrybouski, Robin de Flores, Eli Gibson, Paul A. Yushkevich, David A. Wolk","doi":"10.1002/alz.14492","DOIUrl":"https://doi.org/10.1002/alz.14492","url":null,"abstract":"The generalizability of neuroimaging and cognitive biomarkers in their sensitivity to detect preclinical Alzheimer's disease (AD) and power to predict progression in large, multisite cohorts remains unclear.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"34 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compositional brain scores capture Alzheimer's disease–specific structural brain patterns along the disease continuum","authors":"Patricia Genius, M. Luz Calle, Blanca Rodríguez-Fernández, Carolina Minguillon, Raffaele Cacciaglia, Diego Garrido-Martin, Manel Esteller, Arcadi Navarro, Juan Domingo Gispert, Natalia Vilor-Tejedor, ","doi":"10.1002/alz.14490","DOIUrl":"https://doi.org/10.1002/alz.14490","url":null,"abstract":"Traditional multivariate methods for neuroimaging studies overlook the interdependent relationship between brain features. This study addresses this gap by analyzing relative brain volumetric patterns to capture how Alzheimer's disease (AD) and genetics influence brain structure along the disease continuum.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"4 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerometer-measured physical activity timing with incident dementia","authors":"Yuye Ning, Meilin Chen, Hao Yang, Jianping Jia","doi":"10.1002/alz.14452","DOIUrl":"https://doi.org/10.1002/alz.14452","url":null,"abstract":"Moderate to vigorous physical activity (MVPA) is linked to lower dementia risk, though the optimal timing remains unclear.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"120 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural language processing-based classification of early Alzheimer's disease from connected speech","authors":"Helena Balabin, Bastiaan Tamm, Laure Spruyt, Nathalie Dusart, Ines Kabouche, Ella Eycken, Kevin Statz, Steffi De Meyer, Hugo Van Hamme, Patrick Dupont, Marie-Francine Moens, Rik Vandenberghe","doi":"10.1002/alz.14530","DOIUrl":"https://doi.org/10.1002/alz.14530","url":null,"abstract":"The automated analysis of connected speech using natural language processing (NLP) emerges as a possible biomarker for Alzheimer's disease (AD). However, it remains unclear which types of connected speech are most sensitive and specific for the detection of AD.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"38 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}