Htet Lin Htun, Achamyeleh Birhanu Teshale, Joanne Ryan, Alice J. Owen, Trevor T.-J. Chong, Suzanne G. Orchard, Anne M. Murray, Raj C. Shah, Robyn L. Woods, Rosanne Freak-Poli
Social determinants of health (SDH) are recognized as contributing factors to cognitive disorders, but their collective influence on dementia risk remains unclear.
{"title":"Social determinants of health and risk of dementia among older men and women: A 12-year cohort study in Australia","authors":"Htet Lin Htun, Achamyeleh Birhanu Teshale, Joanne Ryan, Alice J. Owen, Trevor T.-J. Chong, Suzanne G. Orchard, Anne M. Murray, Raj C. Shah, Robyn L. Woods, Rosanne Freak-Poli","doi":"10.1002/alz.70065","DOIUrl":"https://doi.org/10.1002/alz.70065","url":null,"abstract":"Social determinants of health (SDH) are recognized as contributing factors to cognitive disorders, but their collective influence on dementia risk remains unclear.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"200 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cassidy P. Molinare, Daniel Soberanes, Mark Dubbelman, Stephanie Hsieh, Keith A. Johnson, Dorene M. Rentz, Reisa A. Sperling, Gad A. Marshall, Rebecca E. Amariglio, Kathryn V. Papp, Roos J. Jutten
Accelerated long-term forgetting (LTF) might be an early marker of subtle memory changes in older adults at risk for Alzheimer's disease (AD). We leveraged remote, multi-day digital testing to characterize LTF in older adults and investigated its association with initial learning and AD imaging biomarkers.
{"title":"Using remote, digital, multi-day testing to characterize long-term forgetting in cognitively unimpaired older adults","authors":"Cassidy P. Molinare, Daniel Soberanes, Mark Dubbelman, Stephanie Hsieh, Keith A. Johnson, Dorene M. Rentz, Reisa A. Sperling, Gad A. Marshall, Rebecca E. Amariglio, Kathryn V. Papp, Roos J. Jutten","doi":"10.1002/alz.70047","DOIUrl":"https://doi.org/10.1002/alz.70047","url":null,"abstract":"Accelerated long-term forgetting (LTF) might be an early marker of subtle memory changes in older adults at risk for Alzheimer's disease (AD). We leveraged remote, multi-day digital testing to characterize LTF in older adults and investigated its association with initial learning and AD imaging biomarkers.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"26 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charly Abi-Ghanem, Richard D. Kelly, Emily A. Groom, Caitlin G. Valerian, Aaron S. Paul, Christina A. Thrasher, Abigail E. Salinero, Molly R. Batchelder, Jennifer J Lafrican, Matthew Wang, Rachel M. Smith, Sally Temple, Damian G. Zuloaga, Kristen L. Zuloaga
Post-menopausal women constitute about two-thirds of those with Alzheimer's disease (AD). Menopause increases dementia risk by heightening the likelihood of metabolic disease, a well-known risk factor for dementia. We aimed to determine the effects of menopause and high-fat diet (HF) on cognitive and pathological outcomes in an AD mouse model.
{"title":"Interactions between menopause and high-fat diet on cognition and pathology in a mouse model of Alzheimer's disease","authors":"Charly Abi-Ghanem, Richard D. Kelly, Emily A. Groom, Caitlin G. Valerian, Aaron S. Paul, Christina A. Thrasher, Abigail E. Salinero, Molly R. Batchelder, Jennifer J Lafrican, Matthew Wang, Rachel M. Smith, Sally Temple, Damian G. Zuloaga, Kristen L. Zuloaga","doi":"10.1002/alz.70026","DOIUrl":"https://doi.org/10.1002/alz.70026","url":null,"abstract":"Post-menopausal women constitute about two-thirds of those with Alzheimer's disease (AD). Menopause increases dementia risk by heightening the likelihood of metabolic disease, a well-known risk factor for dementia. We aimed to determine the effects of menopause and high-fat diet (HF) on cognitive and pathological outcomes in an AD mouse model.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"126 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olivia Wagemann, Georg Nübling, Francisco Jesús Martínez-Murcia, Elisabeth Wlasich, Sandra V. Loosli, Katja Sandkühler, Anna Stockbauer, Catharina Prix, Sabrina Katzdobler, Agnese Petrera, Stefanie M. Hauck, Juan Fortea, Rocío Romero-Zaliz, Carmen Jiménez-Mesa, Juan M. Górriz Sáez, Günter Höglinger, Johannes Levin
Adults with Down syndrome (DS) show increased risk for Alzheimer's disease (AD) due to the triplication of chromosome 21 encoding the amyloid precursor protein gene. Further, this triplication possibly contributes to dysregulation of the immune system, furthering AD pathophysiology.
{"title":"Exploratory analysis of the proteomic profile in plasma in adults with Down syndrome in the context of Alzheimer's disease","authors":"Olivia Wagemann, Georg Nübling, Francisco Jesús Martínez-Murcia, Elisabeth Wlasich, Sandra V. Loosli, Katja Sandkühler, Anna Stockbauer, Catharina Prix, Sabrina Katzdobler, Agnese Petrera, Stefanie M. Hauck, Juan Fortea, Rocío Romero-Zaliz, Carmen Jiménez-Mesa, Juan M. Górriz Sáez, Günter Höglinger, Johannes Levin","doi":"10.1002/alz.70040","DOIUrl":"https://doi.org/10.1002/alz.70040","url":null,"abstract":"Adults with Down syndrome (DS) show increased risk for Alzheimer's disease (AD) due to the triplication of chromosome 21 encoding the <i>amyloid precursor protein</i> gene. Further, this triplication possibly contributes to dysregulation of the immune system, furthering AD pathophysiology.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"61 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shu Liu, Paul Maruff, Martin Saint-Jalmes, Pierrick Bourgeat, Colin L. Masters, Benjamin Goudey
Integrating non-invasive measures to estimate abnormal amyloid beta accumulation (Aβ+) is key to developing a screening tool for preclinical Alzheimer's disease (AD). The predictive capability of standard neuropsychological tests in estimating Aβ+ has not been quantified.
{"title":"Predicting amyloid beta accumulation in cognitively unimpaired older adults: Cognitive assessments provide no additional utility beyond demographic and genetic factors","authors":"Shu Liu, Paul Maruff, Martin Saint-Jalmes, Pierrick Bourgeat, Colin L. Masters, Benjamin Goudey","doi":"10.1002/alz.70036","DOIUrl":"https://doi.org/10.1002/alz.70036","url":null,"abstract":"Integrating non-invasive measures to estimate abnormal amyloid beta accumulation (Aβ+) is key to developing a screening tool for preclinical Alzheimer's disease (AD). The predictive capability of standard neuropsychological tests in estimating Aβ+ has not been quantified.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"102 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kelsey R. Sewell, Lauren E. Oberlin, Thomas K. Karikari, Marcos Olvera-Rojas, Lu Wan, Jill K. Morris, Paul J. Kueck, Xuemei Zeng, Haiqing Huang, George Grove, Yijun Chen, Tara K. Lafferty, Anuradha Sehrawat, M. Ilyas Kamboh, Anna L. Marsland, Arthur F. Kramer, Edward McAuley, Jeffrey M. Burns, Charles H. Hillman, Eric D. Vidoni, Chaeryon Kang, Kirk I. Erickson
The utility of blood-based biomarkers for discriminating Alzheimer's disease (AD)-related versus non-AD-related cognitive deficits in preclinical populations remains poorly understood. Here, we tested the capability of blood markers to detect and discriminate variation in performance across multiple cognitive domains in a cognitively unimpaired sample.
{"title":"Blood biomarkers differentiate AD-related versus non-AD-related cognitive deficits","authors":"Kelsey R. Sewell, Lauren E. Oberlin, Thomas K. Karikari, Marcos Olvera-Rojas, Lu Wan, Jill K. Morris, Paul J. Kueck, Xuemei Zeng, Haiqing Huang, George Grove, Yijun Chen, Tara K. Lafferty, Anuradha Sehrawat, M. Ilyas Kamboh, Anna L. Marsland, Arthur F. Kramer, Edward McAuley, Jeffrey M. Burns, Charles H. Hillman, Eric D. Vidoni, Chaeryon Kang, Kirk I. Erickson","doi":"10.1002/alz.14619","DOIUrl":"https://doi.org/10.1002/alz.14619","url":null,"abstract":"The utility of blood-based biomarkers for discriminating Alzheimer's disease (AD)-related versus non-AD-related cognitive deficits in preclinical populations remains poorly understood. Here, we tested the capability of blood markers to detect and discriminate variation in performance across multiple cognitive domains in a cognitively unimpaired sample.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"20 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah E. Elzinga, Kai Guo, Ali Turfah, Rosemary E. Henn, Ian F. Webber-Davis, John M. Hayes, Crystal M. Pacut, Samuel J. Teener, Andrew D. Carter, Diana M. Rigan, Adam M. Allouch, Dae-Gyu Jang, Rachel Parent, Emily Glass, Geoffrey G. Murphy, Stephen I. Lentz, Kevin S. Chen, Lili Zhao, Junguk Hur, Eva L. Feldman
Metabolic stressors (obesity, metabolic syndrome, prediabetes, and type 2 diabetes [T2D]) increase the risk of cognitive impairment (CI), including Alzheimer's disease (AD). Immune system dysregulation and inflammation, particularly microglial mediated, may underlie this risk, but mechanisms remain unclear.
{"title":"Metabolic stress and age drive inflammation and cognitive decline in mice and humans","authors":"Sarah E. Elzinga, Kai Guo, Ali Turfah, Rosemary E. Henn, Ian F. Webber-Davis, John M. Hayes, Crystal M. Pacut, Samuel J. Teener, Andrew D. Carter, Diana M. Rigan, Adam M. Allouch, Dae-Gyu Jang, Rachel Parent, Emily Glass, Geoffrey G. Murphy, Stephen I. Lentz, Kevin S. Chen, Lili Zhao, Junguk Hur, Eva L. Feldman","doi":"10.1002/alz.70060","DOIUrl":"https://doi.org/10.1002/alz.70060","url":null,"abstract":"Metabolic stressors (obesity, metabolic syndrome, prediabetes, and type 2 diabetes [T2D]) increase the risk of cognitive impairment (CI), including Alzheimer's disease (AD). Immune system dysregulation and inflammation, particularly microglial mediated, may underlie this risk, but mechanisms remain unclear.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"7 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alma Ghirelli, Austin W. Goodrich, Yehkyoung C. Stephens, Jonathan Graff-Radford, Farwa Ali, Mary M. Machulda, Chistopher G. Schwarz, Matthew L. Senjem, Federica Agosta, Massimo Filippi, Clifford R. Jack, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell
Alzheimer's disease (AD) pathology causes corticobasal syndrome (CBS) in 21%–50% of patients. Studies have assessed hypometabolism in CBS according to β-amyloid (A) positron emission tomography (PET), but the understanding of the association of both AD-tau (T) and A with hypometabolism is incomplete.
{"title":"Relationships between hypometabolism and both β-amyloid and tau PET in corticobasal syndrome","authors":"Alma Ghirelli, Austin W. Goodrich, Yehkyoung C. Stephens, Jonathan Graff-Radford, Farwa Ali, Mary M. Machulda, Chistopher G. Schwarz, Matthew L. Senjem, Federica Agosta, Massimo Filippi, Clifford R. Jack, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell","doi":"10.1002/alz.70018","DOIUrl":"https://doi.org/10.1002/alz.70018","url":null,"abstract":"Alzheimer's disease (AD) pathology causes corticobasal syndrome (CBS) in 21%–50% of patients. Studies have assessed hypometabolism in CBS according to β-amyloid (A) positron emission tomography (PET), but the understanding of the association of both AD-tau (T) and A with hypometabolism is incomplete.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"14 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karly A. Cody, Lianlian Du, Rachel L. Studer, Erin M. Jonaitis, Sanjay Asthana, Bradley T. Christian, Nathaniel A. Chin, Kris M. Kirmess, Matthew R. Meyer, Kevin E. Yarasheski, Tim West, Philip B. Verghese, Joel B. Braunstein, Tobey J. Betthauser, Rebecca E. Langhough, Sterling C. Johnson
Plasma biomarkers sensitive to Alzheimer's disease (AD) proteinopathy prior to the onset of dementia have significant implications for early detection.
{"title":"Accuracy of plasma biomarkers to detect Alzheimer's disease proteinopathy prior to dementia","authors":"Karly A. Cody, Lianlian Du, Rachel L. Studer, Erin M. Jonaitis, Sanjay Asthana, Bradley T. Christian, Nathaniel A. Chin, Kris M. Kirmess, Matthew R. Meyer, Kevin E. Yarasheski, Tim West, Philip B. Verghese, Joel B. Braunstein, Tobey J. Betthauser, Rebecca E. Langhough, Sterling C. Johnson","doi":"10.1002/alz.14570","DOIUrl":"https://doi.org/10.1002/alz.14570","url":null,"abstract":"Plasma biomarkers sensitive to Alzheimer's disease (AD) proteinopathy prior to the onset of dementia have significant implications for early detection.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"91 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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