Anna McKeever, Peter Swann, Maura Malpetti, Paul C. Donaghy, Alan Thomas, Elijah Mak, Stephen F. Carter, Jerry H. K. Tan, Young T. Hong, Tim D. Fryer, Amanda Heslegrave, Henrik Zetterberg, Li Su, Leonidas Chouliaras, James B. Rowe, John T. O'Brien
Lewy body dementia (LBD) shares genetic risk factors with Alzheimer's disease (AD), including apolipoprotein E (APOE), but is distinguishable at the genome-wide level. Polygenic risk scores (PRS) may therefore improve diagnostic classification.
{"title":"Polygenic risk discriminates Lewy body dementia from Alzheimer's disease","authors":"Anna McKeever, Peter Swann, Maura Malpetti, Paul C. Donaghy, Alan Thomas, Elijah Mak, Stephen F. Carter, Jerry H. K. Tan, Young T. Hong, Tim D. Fryer, Amanda Heslegrave, Henrik Zetterberg, Li Su, Leonidas Chouliaras, James B. Rowe, John T. O'Brien","doi":"10.1002/alz.14381","DOIUrl":"https://doi.org/10.1002/alz.14381","url":null,"abstract":"Lewy body dementia (LBD) shares genetic risk factors with Alzheimer's disease (AD), including apolipoprotein E <i>(APOE</i>), but is distinguishable at the genome-wide level. Polygenic risk scores (PRS) may therefore improve diagnostic classification.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"38 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yue Cai, Lili Fang, Anqi Li, Jie Yang, Xin Zhou, Zhengbo He, Pan Sun, Qingyong Wang, Tengfei Guo
Alzheimer's disease (AD) patients with higher educational attainment (EA) often exhibit better cognitive function. However, the relationship among EA status, AD pathology, structural brain reserve, and cognitive decline requires further investigation.
{"title":"Educational attainment, Aβ, tau, and structural brain reserve in Alzheimer's disease","authors":"Yue Cai, Lili Fang, Anqi Li, Jie Yang, Xin Zhou, Zhengbo He, Pan Sun, Qingyong Wang, Tengfei Guo","doi":"10.1002/alz.14400","DOIUrl":"https://doi.org/10.1002/alz.14400","url":null,"abstract":"Alzheimer's disease (AD) patients with higher educational attainment (EA) often exhibit better cognitive function. However, the relationship among EA status, AD pathology, structural brain reserve, and cognitive decline requires further investigation.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"74 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Myrstad, Bo Lars Engdahl, Sergi Gonzalez Costafreda, Steinar Krokstad, Gill Livingston, Geir Selbæk
INTRODUCTIONHearing impairment is associated with dementia. We aimed to clarify the association between hearing impairment and future cognitive test performance measured by the Montreal Cognitive Assessment Scale (MoCA), adjusted for confounders, avoiding reverse causation through long follow‐up.METHODSWe used the Norwegian population‐based longitudinal cohort study, The Trøndelag Health Study (HUNT). At baseline, we invited all residents 20+ for an audiometric hearing assessment, and at 20+ years follow‐up, we cognitively assessed all persons 70+ including MoCA adjusted for hearing impairment. We analyzed the association using linear regression.RESULTSWe included 6879 persons (mean 56.1 years, standard deviation 6.2). At follow‐up, the MoCA score was −0.25 (95% confidence interval [CI] −0.35, −0.14), per 10 dB increase in hearing threshold and for persons < 85 years, −0.31 (95% CI −0.42, −0.20).DISCUSSIONThis study finds a long‐term association between hearing impairment and dose related reduced cognitive performance, particularly in those aged < 85.CLINICAL TRIAL REGISTRATIONID NCT04284384, hearing impairment as a risk factor for dementia in older adults.HighlightsHearing loss predicts long‐term cognitive decline measured by MoCA over 20+ years.Long follow‐up is crucial to avoid reverse causation in the hearing‐cognition relationship.A 10 dB hearing threshold increase is linked to a 0.25‐point reduction in MoCA score.Strongest cognitive decline associations are seen in people aged below 85 years.The association remained after excluding hearing‐dependent tasks in the MoCA.
{"title":"Hearing and cognitive scores measured with the Montreal Cognitive Assessment Scale in The HUNT Study, Norway","authors":"Christian Myrstad, Bo Lars Engdahl, Sergi Gonzalez Costafreda, Steinar Krokstad, Gill Livingston, Geir Selbæk","doi":"10.1002/alz.14514","DOIUrl":"https://doi.org/10.1002/alz.14514","url":null,"abstract":"INTRODUCTIONHearing impairment is associated with dementia. We aimed to clarify the association between hearing impairment and future cognitive test performance measured by the Montreal Cognitive Assessment Scale (MoCA), adjusted for confounders, avoiding reverse causation through long follow‐up.METHODSWe used the Norwegian population‐based longitudinal cohort study, The Trøndelag Health Study (HUNT). At baseline, we invited all residents 20+ for an audiometric hearing assessment, and at 20+ years follow‐up, we cognitively assessed all persons 70+ including MoCA adjusted for hearing impairment. We analyzed the association using linear regression.RESULTSWe included 6879 persons (mean 56.1 years, standard deviation 6.2). At follow‐up, the MoCA score was −0.25 (95% confidence interval [CI] −0.35, −0.14), per 10 dB increase in hearing threshold and for persons < 85 years, −0.31 (95% CI −0.42, −0.20).DISCUSSIONThis study finds a long‐term association between hearing impairment and dose related reduced cognitive performance, particularly in those aged < 85.CLINICAL TRIAL REGISTRATIONID NCT04284384, hearing impairment as a risk factor for dementia in older adults.Highlights<jats:list list-type=\"bullet\"> <jats:list-item>Hearing loss predicts long‐term cognitive decline measured by MoCA over 20+ years.</jats:list-item> <jats:list-item>Long follow‐up is crucial to avoid reverse causation in the hearing‐cognition relationship.</jats:list-item> <jats:list-item>A 10 dB hearing threshold increase is linked to a 0.25‐point reduction in MoCA score.</jats:list-item> <jats:list-item>Strongest cognitive decline associations are seen in people aged below 85 years.</jats:list-item> <jats:list-item>The association remained after excluding hearing‐dependent tasks in the MoCA.</jats:list-item> </jats:list>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"62 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
So Young Moon, Yoo Kyoung Park, Jee Hyang Jeong, Chang Hyung Hong, Jiwoo Jung, Hae Ri Na, Soo Hyun Cho, Hyun Sook Kim, Hong-Sun Song, Muncheong Choi, Bon D. Ku, Yeon Sil Moon, Hyun Jeong Han, Yun Jeong Hong, Eun-Joo Kim, Geon Ha Kim, Ko Woon Kim, Hyemin Jang, Soo Jin Yoon, Hee-Jin Kim, Seong Hye Choi
We investigated the efficacy of a multidomain intervention (MI) via face-to-face and video communication platforms using a tablet personal computer application in patients with mild cognitive impairment (MCI).
{"title":"South Korean study to prevent cognitive impairment and protect brain health through multidomain interventions via face-to-face and video communication platforms in mild cognitive impairment (SUPERBRAIN-MEET): A randomized controlled trial","authors":"So Young Moon, Yoo Kyoung Park, Jee Hyang Jeong, Chang Hyung Hong, Jiwoo Jung, Hae Ri Na, Soo Hyun Cho, Hyun Sook Kim, Hong-Sun Song, Muncheong Choi, Bon D. Ku, Yeon Sil Moon, Hyun Jeong Han, Yun Jeong Hong, Eun-Joo Kim, Geon Ha Kim, Ko Woon Kim, Hyemin Jang, Soo Jin Yoon, Hee-Jin Kim, Seong Hye Choi","doi":"10.1002/alz.14517","DOIUrl":"https://doi.org/10.1002/alz.14517","url":null,"abstract":"We investigated the efficacy of a multidomain intervention (MI) via face-to-face and video communication platforms using a tablet personal computer application in patients with mild cognitive impairment (MCI).","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"32 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ye Xie, Tinghao Zhao, Wei Zhang, Qi Chen, Anqi Qiu, Yunxia Li, Yixuan Ku
Visual short-term memory (VSTM) is a critical indicator of Alzheimer's disease (AD), but whether its neural substrates could adapt to early disease progression and contribute to cognitive resilience in amnestic mild cognitive impairment (aMCI) has been unclear.
{"title":"Neural deterioration and compensation in visual short-term memory among individuals with amnestic mild cognitive impairment","authors":"Ye Xie, Tinghao Zhao, Wei Zhang, Qi Chen, Anqi Qiu, Yunxia Li, Yixuan Ku","doi":"10.1002/alz.14475","DOIUrl":"https://doi.org/10.1002/alz.14475","url":null,"abstract":"Visual short-term memory (VSTM) is a critical indicator of Alzheimer's disease (AD), but whether its neural substrates could adapt to early disease progression and contribute to cognitive resilience in amnestic mild cognitive impairment (aMCI) has been unclear.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"20 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guoyu Lan, Laihong Zhang, Anqi Li, Wenqing Ran, Jieqin Lv, Fernando Gonzalez-Ortiz, Yue Cai, Pan Sun, Lin Liu, Jie Yang, Zhengbo He, Lili Fang, Xin Zhou, Yalin Zhu, Zhen Liu, Xuhui Chen, Xiang Fan, Dai Shi, Chenghui Ye, Linsen Xu, Qingyong Wang, Kaj Blennow, Guanxun Cheng, , Pengcheng Ran, Lu Wang, Tengfei Guo
Novel fluid biomarkers for tracking neurodegeneration specific to Alzheimer's disease (AD) are greatly needed.
迫切需要新的液体生物标志物来跟踪阿尔茨海默病（AD）特异性的神经退行性变。
{"title":"Plasma N-terminal tau fragment is an amyloid-dependent biomarker in Alzheimer's disease","authors":"Guoyu Lan, Laihong Zhang, Anqi Li, Wenqing Ran, Jieqin Lv, Fernando Gonzalez-Ortiz, Yue Cai, Pan Sun, Lin Liu, Jie Yang, Zhengbo He, Lili Fang, Xin Zhou, Yalin Zhu, Zhen Liu, Xuhui Chen, Xiang Fan, Dai Shi, Chenghui Ye, Linsen Xu, Qingyong Wang, Kaj Blennow, Guanxun Cheng, , Pengcheng Ran, Lu Wang, Tengfei Guo","doi":"10.1002/alz.14550","DOIUrl":"https://doi.org/10.1002/alz.14550","url":null,"abstract":"Novel fluid biomarkers for tracking neurodegeneration specific to Alzheimer's disease (AD) are greatly needed.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"118 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
May A. Beydoun, Hind A. Beydoun, Nicole Noren Hooten, Zhiguang Li, Yi-Han Hu, Michael F. Georgescu, Sharmin Hossain, Toshiko Tanaka, Mustapha Bouhrara, Christian A. Maino Vieytes, Marie T. Fanelli-Kuczmarski, Lenore J. Launer, Michele K. Evans, Alan B. Zonderman
The plasma proteome's mediating or moderating roles in the association between poor cardiovascular health (CVH) and brain white matter (WM) microstructural integrity are largely unknown.
{"title":"Plasma proteomic biomarkers as mediators or moderators for the association between poor cardiovascular health and white matter microstructural integrity: The UK Biobank study","authors":"May A. Beydoun, Hind A. Beydoun, Nicole Noren Hooten, Zhiguang Li, Yi-Han Hu, Michael F. Georgescu, Sharmin Hossain, Toshiko Tanaka, Mustapha Bouhrara, Christian A. Maino Vieytes, Marie T. Fanelli-Kuczmarski, Lenore J. Launer, Michele K. Evans, Alan B. Zonderman","doi":"10.1002/alz.14507","DOIUrl":"https://doi.org/10.1002/alz.14507","url":null,"abstract":"The plasma proteome's mediating or moderating roles in the association between poor cardiovascular health (CVH) and brain white matter (WM) microstructural integrity are largely unknown.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"2 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiahui Li, Yifei Ren, Lidan Wang, Xinrui Zou, Xueran Ding, Tingting Hou, Qinghua Zhang, Shi Tang, Xiaojuan Han, Lin Song, Yajun Liang, Yongxiang Wang, Lin Cong, Yifeng Du, Chengxuan Qiu
To examine the longitudinal association between estimated pulse wave velocity (ePWV) and cognitive phenotypes in a rural Chinese older population.
目的：探讨中国农村老年人脉搏波速度与认知表型之间的纵向关系。
{"title":"Estimated pulse wave velocity associated with cognitive phenotypes in a rural older population in China: A cohort study","authors":"Jiahui Li, Yifei Ren, Lidan Wang, Xinrui Zou, Xueran Ding, Tingting Hou, Qinghua Zhang, Shi Tang, Xiaojuan Han, Lin Song, Yajun Liang, Yongxiang Wang, Lin Cong, Yifeng Du, Chengxuan Qiu","doi":"10.1002/alz.14491","DOIUrl":"https://doi.org/10.1002/alz.14491","url":null,"abstract":"To examine the longitudinal association between estimated pulse wave velocity (ePWV) and cognitive phenotypes in a rural Chinese older population.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"6 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miao Ren, Yuxiao Li, Tao Jiang, Bimin Liu, Xuhan Li, Xueyan Jia, Anan Li, Qingming Luo, Hui Gong, Xiangning Li
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by damage to cortical circuits. However, the mechanisms underlying AD-associated changes in long-range circuits remain poorly understood.
{"title":"Long-range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse","authors":"Miao Ren, Yuxiao Li, Tao Jiang, Bimin Liu, Xuhan Li, Xueyan Jia, Anan Li, Qingming Luo, Hui Gong, Xiangning Li","doi":"10.1002/alz.14552","DOIUrl":"https://doi.org/10.1002/alz.14552","url":null,"abstract":"Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by damage to cortical circuits. However, the mechanisms underlying AD-associated changes in long-range circuits remain poorly understood.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"25 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicola Coley, Marieke P. Hoevenaar-Blom, Jason Shourick, Eric P. Moll van Charante, Jan-Willem van Dalen, Willem A. van Gool, Edo Richard, Sandrine Andrieu
It is unknown in which, if any, subgroups of older adults multidomain interventions are effective at reducing long-term dementia incidence.
目前尚不清楚老年人多领域干预在哪些亚组中有效降低长期痴呆发病率。
{"title":"Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials","authors":"Nicola Coley, Marieke P. Hoevenaar-Blom, Jason Shourick, Eric P. Moll van Charante, Jan-Willem van Dalen, Willem A. van Gool, Edo Richard, Sandrine Andrieu","doi":"10.1002/alz.14472","DOIUrl":"https://doi.org/10.1002/alz.14472","url":null,"abstract":"It is unknown in which, if any, subgroups of older adults multidomain interventions are effective at reducing long-term dementia incidence.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"93 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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