BACKGROUND:Assessment of gestational age of babies has been in existence for many years. There are several methods available which are used routinely. Some of these can assess gestational age prenatally while others are used postnatally.The importance of assessing gestational age cannot be overemphasized. It helps to anticipate problems that a newborn may develop and thereby ensures prompt management. It also helps to categorize low birth weight babies into preterm, small for gestational age or both and these all require different approaches to management. In our environment where pregnancy dates are sometimes uncertain, assessment of gestational age may help meet the needs of the newborn.METHOD: This is a review of various methods of assessing gestational age. Literature search was made through locally available literature, Google search engine, Pubmed and Medline search.
{"title":"Gestational Age Assessment In The Newborn – A Review","authors":"P. Opara","doi":"10.5580/1295","DOIUrl":"https://doi.org/10.5580/1295","url":null,"abstract":"BACKGROUND:Assessment of gestational age of babies has been in existence for many years. There are several methods available which are used routinely. Some of these can assess gestational age prenatally while others are used postnatally.The importance of assessing gestational age cannot be overemphasized. It helps to anticipate problems that a newborn may develop and thereby ensures prompt management. It also helps to categorize low birth weight babies into preterm, small for gestational age or both and these all require different approaches to management. In our environment where pregnancy dates are sometimes uncertain, assessment of gestational age may help meet the needs of the newborn.METHOD: This is a review of various methods of assessing gestational age. Literature search was made through locally available literature, Google search engine, Pubmed and Medline search.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arvind Kumar, A. Shrivastava, A. Taksande, D. Singh, R. Rai
Background & objectives: Despite a substantial disease burden in this area, little is known about the natural history of complicated falciparum malaria. Therefore, the present prospective study was undertaken to assess the clinical course, complications and outcome i.e. to understand the pattern of morbidity and mortality of falciparum malaria in children in tertiary care center of Allahabad.Methods: This was a prospective hospital based study conducted on 150 consecutive pediatric admissions under the age group of 1-5 years of slide positive complicated falciparum malaria cases between May 2005 to June 2007. The cases were retrieved and scrutinised using a prepared case sheet performa on the basis of patient’s detailed history, clinical findings, investigations, treatment and complications.Results: 150 children with complicated Falciparum malaria with a mean age of 4.9±4.08 years to look for occurrence of different complications in younger and older age groups and overall mortality picture. Prostration (49.3%), Severe anemia (48.6%), unarousable coma (27.3%), and Respiratory distress(24.0%) were commonest complications. Under five children had higher risk of development of severe anemia (P<0.05) cerebral malaria (P<0.05), respiratory distress (<0.05) and seizures (P<0.05); whereas above five children had higher risk of prostration (P<0.05), jaundice (P<0.05) and acute renal failure (P<0.05). Over all mortality was 13.7%, cerebral malaria being the commonest cause (14.6%). Conclusion : Malaria is responsible for major health concern in this region especially in rural areas, particularly in rainy season and is found to affect comparatively the younger children population. High degree suspicion should be maintained to detect these complications in early stage so that malarial mortality and morbidity can be prevented.
{"title":"Severe P. falciparum malaria in children in a tertiary care center of Allahabad region of india.","authors":"Arvind Kumar, A. Shrivastava, A. Taksande, D. Singh, R. Rai","doi":"10.5580/11e1","DOIUrl":"https://doi.org/10.5580/11e1","url":null,"abstract":"Background & objectives: Despite a substantial disease burden in this area, little is known about the natural history of complicated falciparum malaria. Therefore, the present prospective study was undertaken to assess the clinical course, complications and outcome i.e. to understand the pattern of morbidity and mortality of falciparum malaria in children in tertiary care center of Allahabad.Methods: This was a prospective hospital based study conducted on 150 consecutive pediatric admissions under the age group of 1-5 years of slide positive complicated falciparum malaria cases between May 2005 to June 2007. The cases were retrieved and scrutinised using a prepared case sheet performa on the basis of patient’s detailed history, clinical findings, investigations, treatment and complications.Results: 150 children with complicated Falciparum malaria with a mean age of 4.9±4.08 years to look for occurrence of different complications in younger and older age groups and overall mortality picture. Prostration (49.3%), Severe anemia (48.6%), unarousable coma (27.3%), and Respiratory distress(24.0%) were commonest complications. Under five children had higher risk of development of severe anemia (P<0.05) cerebral malaria (P<0.05), respiratory distress (<0.05) and seizures (P<0.05); whereas above five children had higher risk of prostration (P<0.05), jaundice (P<0.05) and acute renal failure (P<0.05). Over all mortality was 13.7%, cerebral malaria being the commonest cause (14.6%). Conclusion : Malaria is responsible for major health concern in this region especially in rural areas, particularly in rainy season and is found to affect comparatively the younger children population. High degree suspicion should be maintained to detect these complications in early stage so that malarial mortality and morbidity can be prevented.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
At 22 days of life, a girl presented with one day of vomiting after every feed. The vomit was milk colored, without bile or blood. Since birth, she had intermittent vomiting. She had no diarrhea, cough, congestion or fever. Her urine output was decreased. Case and diagnonis are discussed in the case report.
{"title":"Vomiting in a Neonate","authors":"Dorothy T. Damore","doi":"10.5580/2243","DOIUrl":"https://doi.org/10.5580/2243","url":null,"abstract":"At 22 days of life, a girl presented with one day of vomiting after every feed. The vomit was milk colored, without bile or blood. Since birth, she had intermittent vomiting. She had no diarrhea, cough, congestion or fever. Her urine output was decreased. Case and diagnonis are discussed in the case report.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric and geriatric patients, have difficulty swallowing or chewing solid dosage forms. Many pediatric and geriatric patients are unwilling to take solid preparations due to fear of choking. Even with fast dissolving tablets there is a fear of choking due to its tablet type appearance. Hence oral film drug delivery is a better alternative in such cases. The oral films are formulated using polymers, plasticizers, flavors, colors and sweeteners. The oral films are manufactured using solvent casting method, rolling method, extrusion method and solid dispersion method. The films are evaluated for dimensions, disintegration, dissolution, tensile strength and folding endurance. It has many applications like in taste masking, immediate release and sustained release formulation
{"title":"Oral Films - Patient Compliant Dosage Form For Pediatrics","authors":"S. Malke, S. Shidhaye, J. Desai, V. Kadam","doi":"10.5580/44e","DOIUrl":"https://doi.org/10.5580/44e","url":null,"abstract":"Pediatric and geriatric patients, have difficulty swallowing or chewing solid dosage forms. Many pediatric and geriatric patients are unwilling to take solid preparations due to fear of choking. Even with fast dissolving tablets there is a fear of choking due to its tablet type appearance. Hence oral film drug delivery is a better alternative in such cases. The oral films are formulated using polymers, plasticizers, flavors, colors and sweeteners. The oral films are manufactured using solvent casting method, rolling method, extrusion method and solid dispersion method. The films are evaluated for dimensions, disintegration, dissolution, tensile strength and folding endurance. It has many applications like in taste masking, immediate release and sustained release formulation","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70823458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Fuentes, Cecilia Moreno, R. Tejedor, D. Cabezalí, M. Benavent, A. Gómez
Sacrococcygeal teratoma is a well known entity and both its diagnosis and management have been thoroughfully described. Special mention deserves the highly differentiated teratoma as it presents complex organized tissular structures making it slightly different from the classic teratoma although it does not reach the defining characteristics of fetus-in-fetu.A female newborn without prenatal diagnosis presented sacro-coccygeal mass. X-ray image showed bone structures resembling tibia and fibula within the mass. She undertook surgery two days after delivery. Macroscopically, the mass showed besides the bones described on X ray image, cartilaginous structures, some loops of bowel and tissue resembling a finger. There were also some cystic areas. Highly differentiated teratoma also called fetiform teratoma seems to be a defined entity apart from the classical sacrococcygeal teratoma and the fetus-in-fetus. However differences regarding physiopathological and clinical aspects have not been yet completely described.
{"title":"Highly differentiated sacrococcygeal teratoma.","authors":"S. Fuentes, Cecilia Moreno, R. Tejedor, D. Cabezalí, M. Benavent, A. Gómez","doi":"10.5580/c1","DOIUrl":"https://doi.org/10.5580/c1","url":null,"abstract":"Sacrococcygeal teratoma is a well known entity and both its diagnosis and management have been thoroughfully described. Special mention deserves the highly differentiated teratoma as it presents complex organized tissular structures making it slightly different from the classic teratoma although it does not reach the defining characteristics of fetus-in-fetu.A female newborn without prenatal diagnosis presented sacro-coccygeal mass. X-ray image showed bone structures resembling tibia and fibula within the mass. She undertook surgery two days after delivery. Macroscopically, the mass showed besides the bones described on X ray image, cartilaginous structures, some loops of bowel and tissue resembling a finger. There were also some cystic areas. Highly differentiated teratoma also called fetiform teratoma seems to be a defined entity apart from the classical sacrococcygeal teratoma and the fetus-in-fetus. However differences regarding physiopathological and clinical aspects have not been yet completely described.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70826684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Gómez, C. Lopez-Menchero, D. Lozano, P. Oyágüez, Calos Zabaleta
Purpose: This study evaluated the safety and efficacy of a propofol based protocol for deep sedation in spontaneously breathing children undergoing magnetic resonance imaging (MRI) procedures under the direction of the intensive care pediatrician.Methods: Propofol sedation was prospectively studied in 36 MRI procedures. Sedation was induced with 3 mg/k of propofol infused over 6 minutes and maintained with infusion of propofol between 1 and 10 mg/k/h rate. Results: All procedures were completed without any adverse event. The average time for sedation was 30 minutes. The average maintenance rate was 4.99 mg/k/h. The average total dose of propofol was 5.3 mg/k. All patients were in normal ward after MRI procedure. No side effects were observed in recovery period and all patients were discharged in less than two hours.Conclusion: Propofol infusion for sedation in children undergoing MRI procedures can be considered save and acceptable under the direction of intensive care pediatrician.
{"title":"Deep sedation with propofol by pediatric intensive care physician during magnetic resonance imaging procedures: a prospective experience.","authors":"E. Gómez, C. Lopez-Menchero, D. Lozano, P. Oyágüez, Calos Zabaleta","doi":"10.5580/24f7","DOIUrl":"https://doi.org/10.5580/24f7","url":null,"abstract":"Purpose: This study evaluated the safety and efficacy of a propofol based protocol for deep sedation in spontaneously breathing children undergoing magnetic resonance imaging (MRI) procedures under the direction of the intensive care pediatrician.Methods: Propofol sedation was prospectively studied in 36 MRI procedures. Sedation was induced with 3 mg/k of propofol infused over 6 minutes and maintained with infusion of propofol between 1 and 10 mg/k/h rate. Results: All procedures were completed without any adverse event. The average time for sedation was 30 minutes. The average maintenance rate was 4.99 mg/k/h. The average total dose of propofol was 5.3 mg/k. All patients were in normal ward after MRI procedure. No side effects were observed in recovery period and all patients were discharged in less than two hours.Conclusion: Propofol infusion for sedation in children undergoing MRI procedures can be considered save and acceptable under the direction of intensive care pediatrician.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cathryn Carroll, A. El-Khuffash, E. Molloy, S. Knowles, K. Walsh
Objectives: Infective Endocarditis is a rare but potentially serious condition in very low birth weight infants and we aimed to evaluate the incidence and outcomes in this population. Study design: 203 infants <1500g were admitted to the NICU over 24 months. Routine echocardiography was introduced in the unit on all infants <1500g by a neonatologist trained in echocardiography. Echocardiography was specifically requested for persistent positive blood cultures, new onset murmur and patent ductus arteriosus evaluation. Results: Five infants were diagnosed with endocarditis giving an incidence of 2.5% compared to 0.4% in the previous 2 years. There were no cases of Congenital Heart Disease. All infants had a history of central venous or central arterial catheter use and received six weeks of antibiotic treatment. Four infants with endocarditis had persistently positive blood cultures and 2 infants received low molecular weight heparin. In all but one case, the sepsis resolved and the vegetative intracardiac lesions disappeared prior to completion of treatment.Conclusion: The diagnosis of endocarditis increased in VLBWs which coincided with institution of regular echocardiography. Thrombocytopenia, persistent positive blood cultures and a new murmur require urgent echocardiography to outrule endocarditis in VLBW infants.
{"title":"Targeted Neonatal Echocardiography (TnECHO) and Increased Detection of Intracardiac Thrombi and Endocarditis in Very low Birth Weight Infants","authors":"Cathryn Carroll, A. El-Khuffash, E. Molloy, S. Knowles, K. Walsh","doi":"10.5580/1ff4","DOIUrl":"https://doi.org/10.5580/1ff4","url":null,"abstract":"Objectives: Infective Endocarditis is a rare but potentially serious condition in very low birth weight infants and we aimed to evaluate the incidence and outcomes in this population. Study design: 203 infants <1500g were admitted to the NICU over 24 months. Routine echocardiography was introduced in the unit on all infants <1500g by a neonatologist trained in echocardiography. Echocardiography was specifically requested for persistent positive blood cultures, new onset murmur and patent ductus arteriosus evaluation. Results: Five infants were diagnosed with endocarditis giving an incidence of 2.5% compared to 0.4% in the previous 2 years. There were no cases of Congenital Heart Disease. All infants had a history of central venous or central arterial catheter use and received six weeks of antibiotic treatment. Four infants with endocarditis had persistently positive blood cultures and 2 infants received low molecular weight heparin. In all but one case, the sepsis resolved and the vegetative intracardiac lesions disappeared prior to completion of treatment.Conclusion: The diagnosis of endocarditis increased in VLBWs which coincided with institution of regular echocardiography. Thrombocytopenia, persistent positive blood cultures and a new murmur require urgent echocardiography to outrule endocarditis in VLBW infants.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70816900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. I. Fos, R. Gomis, C. V. Gomis, J. Rubio, P. Justich, J. Válera, F. Chicano, E. Borrajo
Background: Sepsis is a significant cause of mortality and morbidity in Neonatology Departments. Frequently neonatologists use the presence of a positive blood culture to confirm diagnosis and then they undergo lumbar puncture. Positive blood cultures are the gold standard and are used to predict neonatal outcome and determine type of antibiotics combination ant length of treatment. Objective: The aim of this study was to obtain blood culture from umbilical vein in newborns with infection risk factors and seeing if its culture is more sensible for isolating micro-organisms. Design: A prospective study of 784 deliveries with 45 infection risk factors newborns Patients: We select a cohort of newborns with perinatal infection risk factors during 3 months. Clinical data for these neonates were recorded prospectively and in the delivery room a blood sample from the umbilical vein was culture. These neonates were followed during almost the firsts 72 hours of live and clinical and laboratory test was made. Results. We obtained a total sample size in this study of 30 blood cultures. From this sample blood culture was positive in 13 (43%) and negative in 17 (57%). Of the 13 positive blood cultures 7 (54%) neonates presents clinical and laboratory findings and sepsis diagnosis was made, 3 (23%) were considered contaminants and 3 (23%) were bacteraemies. In all neonates serial RBC, leukocyte counts and CRP were made and in newborns with positive blood culture a new blood sample for culture and CSF culture was performed. Conclusions: Diagnosis of neonatal sepsis by positive blood culture in clinical practice is difficulted by maternal antibiotic prophylaxis and blood sample size. Various diagnostics approaches are necessary to make diagnosis and to determine the length of therapy. Umbilical vein samples represented a new and more sensible way to diagnostics early neonatal sepsis.
{"title":"Blood Culture From The Umbilical Vein In The Diagnosis Of Neonatal Sepsis.","authors":"N. I. Fos, R. Gomis, C. V. Gomis, J. Rubio, P. Justich, J. Válera, F. Chicano, E. Borrajo","doi":"10.5580/6f0","DOIUrl":"https://doi.org/10.5580/6f0","url":null,"abstract":"Background: Sepsis is a significant cause of mortality and morbidity in Neonatology Departments. Frequently neonatologists use the presence of a positive blood culture to confirm diagnosis and then they undergo lumbar puncture. Positive blood cultures are the gold standard and are used to predict neonatal outcome and determine type of antibiotics combination ant length of treatment. Objective: The aim of this study was to obtain blood culture from umbilical vein in newborns with infection risk factors and seeing if its culture is more sensible for isolating micro-organisms. Design: A prospective study of 784 deliveries with 45 infection risk factors newborns Patients: We select a cohort of newborns with perinatal infection risk factors during 3 months. Clinical data for these neonates were recorded prospectively and in the delivery room a blood sample from the umbilical vein was culture. These neonates were followed during almost the firsts 72 hours of live and clinical and laboratory test was made. Results. We obtained a total sample size in this study of 30 blood cultures. From this sample blood culture was positive in 13 (43%) and negative in 17 (57%). Of the 13 positive blood cultures 7 (54%) neonates presents clinical and laboratory findings and sepsis diagnosis was made, 3 (23%) were considered contaminants and 3 (23%) were bacteraemies. In all neonates serial RBC, leukocyte counts and CRP were made and in newborns with positive blood culture a new blood sample for culture and CSF culture was performed. Conclusions: Diagnosis of neonatal sepsis by positive blood culture in clinical practice is difficulted by maternal antibiotic prophylaxis and blood sample size. Various diagnostics approaches are necessary to make diagnosis and to determine the length of therapy. Umbilical vein samples represented a new and more sensible way to diagnostics early neonatal sepsis.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Roche, T. Moran, R. Wormald, M. Geraghty, A. Blayney, T. O’Dwyer, H. Rowley, M. Colreavy, A. Naudé
Adenotonsillectomy is one of the most frequently performed surgeries in Irish children’s hospitals. It is a major component of the paediatric otolaryngologist’s workload and with a high patient turnover; otolaryngology admissions account for a large percentage of bed occupancy in paediatric hospitals. The primary goal of this prospective surgical and clinical review was to assess the perioperative respiratory risks posed to the cohort. In addition, we aimed to evaluate the impact of rising obesity levels, and to assess changing demographic patterns in our clinics.We carried out a comprehensive review of the aetiology, pathology and risk factors for obstructive sleep apnoea in paediatric adenotonsillectomy patients. Specifically, we assessed the risks associated with a changing paediatric patient population.
{"title":"Obstructive Sleep Apnoea – Is Ethnicity an Independent Risk Factor, in Adenotonsillectomy Patients?","authors":"P. Roche, T. Moran, R. Wormald, M. Geraghty, A. Blayney, T. O’Dwyer, H. Rowley, M. Colreavy, A. Naudé","doi":"10.5580/144e","DOIUrl":"https://doi.org/10.5580/144e","url":null,"abstract":"Adenotonsillectomy is one of the most frequently performed surgeries in Irish children’s hospitals. It is a major component of the paediatric otolaryngologist’s workload and with a high patient turnover; otolaryngology admissions account for a large percentage of bed occupancy in paediatric hospitals. The primary goal of this prospective surgical and clinical review was to assess the perioperative respiratory risks posed to the cohort. In addition, we aimed to evaluate the impact of rising obesity levels, and to assess changing demographic patterns in our clinics.We carried out a comprehensive review of the aetiology, pathology and risk factors for obstructive sleep apnoea in paediatric adenotonsillectomy patients. Specifically, we assessed the risks associated with a changing paediatric patient population.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a case of a stillborn female fetus with combined stigmata of Tuberous Sclerosis Complex (TSC) and cytomegalovirus (CMV) infection. The baby was premature and small for gestational age (1625g). The heart showed multiple cardiac rhabdomyomas. The brain showed cortical tubers and subependymal nodule. Renal cysts are present. Autopsy also revealed multiple organ infected by CMV including lungs, liver and kidneys. The mother was 24 year old. The placental gross findings show multiple hematoma and infarction on maternal side, acute chorionitis with cytomegalovirus infection, chronic deciduitis and focal chronic villitis, might be the cause of the intrauterine demise of the fetus
{"title":"Tuberous Sclerosis Complex with Diffuse Cytomegalovirus Fetal Infection: Case Report and Review of the Literature","authors":"N. Jin, S. Shuja, C. Monteiro, R. Makary","doi":"10.5580/4b1","DOIUrl":"https://doi.org/10.5580/4b1","url":null,"abstract":"We report a case of a stillborn female fetus with combined stigmata of Tuberous Sclerosis Complex (TSC) and cytomegalovirus (CMV) infection. The baby was premature and small for gestational age (1625g). The heart showed multiple cardiac rhabdomyomas. The brain showed cortical tubers and subependymal nodule. Renal cysts are present. Autopsy also revealed multiple organ infected by CMV including lungs, liver and kidneys. The mother was 24 year old. The placental gross findings show multiple hematoma and infarction on maternal side, acute chorionitis with cytomegalovirus infection, chronic deciduitis and focal chronic villitis, might be the cause of the intrauterine demise of the fetus","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70823528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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