M. Osman, Elsharif. A. Bazie, Alamin Mohammed Almustafa Alamin, Muzdalifa Mahmoud Mohammed, Romiusa Murtada Alsmani Saber
Introduction: The most common neurological disorder that affects more than 50 million people worldwide is epilepsy, especially in childhood, adolescence, and the elderly. . It has a prevalence rate of 2.8–19.5/1000 of the general population and is more prevalent in the early years of life. Methodology: Descriptive, cross-sectional hospital-based study design. Result: most of respondents had average to poor knowledge about epilepsy (59%) and poor knowledge about management by (53.5%). caregivers who were not educated were 17(13.4% participants, primary school level in 34(26.8%) participants, secondary school level 43(33.9%) participants, and high graduation level in 33(26%) participants, and (6.3%) of the respondents think that epilepsy is a supernatural disease. Conclusion: Our community still has some misconceptions regarding epilepsy, most of the misconceptions have been due to relating epilepsy to super-natural disease or causes.
{"title":"Knowledge, Attitude, and Practice of Caregivers among Epileptic Pediatric Patients in Jaafer Ibn Auf Hospital-Khartoum-Sudan","authors":"M. Osman, Elsharif. A. Bazie, Alamin Mohammed Almustafa Alamin, Muzdalifa Mahmoud Mohammed, Romiusa Murtada Alsmani Saber","doi":"10.33425/2689-1085.1024","DOIUrl":"https://doi.org/10.33425/2689-1085.1024","url":null,"abstract":"Introduction: The most common neurological disorder that affects more than 50 million people worldwide is epilepsy, especially in childhood, adolescence, and the elderly. . It has a prevalence rate of 2.8–19.5/1000 of the general population and is more prevalent in the early years of life. Methodology: Descriptive, cross-sectional hospital-based study design. Result: most of respondents had average to poor knowledge about epilepsy (59%) and poor knowledge about management by (53.5%). caregivers who were not educated were 17(13.4% participants, primary school level in 34(26.8%) participants, secondary school level 43(33.9%) participants, and high graduation level in 33(26%) participants, and (6.3%) of the respondents think that epilepsy is a supernatural disease. Conclusion: Our community still has some misconceptions regarding epilepsy, most of the misconceptions have been due to relating epilepsy to super-natural disease or causes.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85446168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lemus-Varela Ml, García-Valdez Lm, R. R, Zúñiga-González Gm, G. Mp
Background: Persistent pulmonary hypertension of a newborn (PPHN) is a serious condition with a high morbidity and mortality rate, with a complex therapeutic approach. Recently, genetic associations have been found in patients with PPHN, the role of some polymorphisms that explain its pathogenesis has not been well defined. Objective: To determine the frequency of association of SOD2 gene polymorphisms (rs5746136 C>T) in PPHN in the Mexican population. Methods: We included 155 Mexican infants; 76 with PPHN, confirmed by echocardiography (study group), and 79 healthy newborns (control group) and by polymerase chain reaction (PCR) and RFLPs was identified the rs5746136 polymorphism in SOD2 gene. Results: The group with PPHN had a lower gestational age (35.6 ± 2.81 weeks versus 38.1 ± 1.9; P=0.008) and a lower mean body weight (2,622 ± 626 g versus 2,992 ± 565 g, P=0.052) than the controls respectively. The rs5746136 C>T polymorphism was associated with PPHN susceptibility, when PPHN patients and the control group were compared for the TT genotype (OR 8.1, 95%CI 2.65-24.9; P=0.0001), the CT/TT genotype (OR 6.5, 95% CI 3.12-13.5; P=0.0001), and the T allele (OR 4.3, 95% CI 2.63-7.02; P=0.0001). Conclusion: We found significant differences in the association of rs5746136 C>T polymorphism of SOD2 gene in PPHN of the Mexican population analyzed.
{"title":"Association of the SOD2 Rs5746136 C>T Polymorphisms with The Risk of Persistent Pulmonary Hypertension of The Newborn","authors":"Lemus-Varela Ml, García-Valdez Lm, R. R, Zúñiga-González Gm, G. Mp","doi":"10.33425/2689-1085.1022","DOIUrl":"https://doi.org/10.33425/2689-1085.1022","url":null,"abstract":"Background: Persistent pulmonary hypertension of a newborn (PPHN) is a serious condition with a high morbidity and mortality rate, with a complex therapeutic approach. Recently, genetic associations have been found in patients with PPHN, the role of some polymorphisms that explain its pathogenesis has not been well defined. Objective: To determine the frequency of association of SOD2 gene polymorphisms (rs5746136 C>T) in PPHN in the Mexican population. Methods: We included 155 Mexican infants; 76 with PPHN, confirmed by echocardiography (study group), and 79 healthy newborns (control group) and by polymerase chain reaction (PCR) and RFLPs was identified the rs5746136 polymorphism in SOD2 gene. Results: The group with PPHN had a lower gestational age (35.6 ± 2.81 weeks versus 38.1 ± 1.9; P=0.008) and a lower mean body weight (2,622 ± 626 g versus 2,992 ± 565 g, P=0.052) than the controls respectively. The rs5746136 C>T polymorphism was associated with PPHN susceptibility, when PPHN patients and the control group were compared for the TT genotype (OR 8.1, 95%CI 2.65-24.9; P=0.0001), the CT/TT genotype (OR 6.5, 95% CI 3.12-13.5; P=0.0001), and the T allele (OR 4.3, 95% CI 2.63-7.02; P=0.0001). Conclusion: We found significant differences in the association of rs5746136 C>T polymorphism of SOD2 gene in PPHN of the Mexican population analyzed.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86269603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
sabell B. Purdy, Amy D. Paz, R. Findlay, S. Vangala, U. Devaskar
The objective was to test for hypothyroidism (HYT) in infants with Down Syndrome (DS) who tested euthyroid on state newborn screening for congenital HYT. In 39 infants with DS who were euthyroid at birth, serum TSH, total T4 (TT4) and free T4 (FT4) levels were measured during 15 to 120 days of age. TSH, TT4 and FT4 were measured by standard techniques. Depending up on age specific TSH and thyroid hormone (TH) levels, babies were classified as: Euthyroid (normal TSH and normal TH), Primary HYT (high TSH and low TH), compensated HYT (high TSH and normal TH) and sick thyroid (low TSH and low TH). Comparisons among different groups were performed using two-sample t-tests. Twenty-nine babies (72%) remained euthyroid (TSH 6.1 ± 2.6 mIU/ml, TT4 10.8 ± 1.8 µg/ dl and FT4 1.57 ± 0.4 ng/dl). Six (18%) babies developed primary HYT (TSH 23.5 ± 10, TT4 5.1 ± 1.2, FT4 1.17 ± 0.2) within a month of life needing T4 therapy. While 4 (10%) babies developed compensated HYT (TSH 29.3 ± 10, TT4 10.6 ± 3.6 and FT4 1.83 ± 0.3), one (2.5%) had sick thyroid syndrome (TSH 4.6, TT4 4.6 and FT4 1.1). All four babies with compensated HYT were euthyroid by four months of age. Despite normal newborn screening at birth, the incidence of any HYT was much higher (28 %) than the normal neonatal population (1/2000-4000). More importantly, HYT developed within a month of age. Recommendations by the AAP about retesting TH function in infants with DS should be revised.
{"title":"High Incidence of Hypothyroidism Within a Month in Neonates with Down Syndrome Who Are Euthyroid at Birth: Results of A Prospective Study","authors":"sabell B. Purdy, Amy D. Paz, R. Findlay, S. Vangala, U. Devaskar","doi":"10.33425/2689-1085.1023","DOIUrl":"https://doi.org/10.33425/2689-1085.1023","url":null,"abstract":"The objective was to test for hypothyroidism (HYT) in infants with Down Syndrome (DS) who tested euthyroid on state newborn screening for congenital HYT. In 39 infants with DS who were euthyroid at birth, serum TSH, total T4 (TT4) and free T4 (FT4) levels were measured during 15 to 120 days of age. TSH, TT4 and FT4 were measured by standard techniques. Depending up on age specific TSH and thyroid hormone (TH) levels, babies were classified as: Euthyroid (normal TSH and normal TH), Primary HYT (high TSH and low TH), compensated HYT (high TSH and normal TH) and sick thyroid (low TSH and low TH). Comparisons among different groups were performed using two-sample t-tests. Twenty-nine babies (72%) remained euthyroid (TSH 6.1 ± 2.6 mIU/ml, TT4 10.8 ± 1.8 µg/ dl and FT4 1.57 ± 0.4 ng/dl). Six (18%) babies developed primary HYT (TSH 23.5 ± 10, TT4 5.1 ± 1.2, FT4 1.17 ± 0.2) within a month of life needing T4 therapy. While 4 (10%) babies developed compensated HYT (TSH 29.3 ± 10, TT4 10.6 ± 3.6 and FT4 1.83 ± 0.3), one (2.5%) had sick thyroid syndrome (TSH 4.6, TT4 4.6 and FT4 1.1). All four babies with compensated HYT were euthyroid by four months of age. Despite normal newborn screening at birth, the incidence of any HYT was much higher (28 %) than the normal neonatal population (1/2000-4000). More importantly, HYT developed within a month of age. Recommendations by the AAP about retesting TH function in infants with DS should be revised.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85197591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diouf Jbn, Sougou Nm, Tall Ct, K. M, Sarr Lp, N. O
Introduction: Deficiency malnutrition poses a real public health problem, especially in developing countries. The objective of this study is to assess: (a) the prevalence of deficiency malnutrition in its various forms in children aged 6 - 59 months living in Guédiawaye and (b) its determinants. Materials and Methods: This descriptive and analytical cross-sectional study took place from September 1 to October 30, 2020 throughout the district of Guédiawaye in community. The study population consisted of children aged 6 - 59 months. Sampling with no survey was carried out and the total sample consisted of 603 subjects. Results: Twenty-nine point three percent (29.3%) of the children were acutely malnourished, 20.4% chronically malnourished, and 25.5% were underweight. Early breastfeeding was performed in 62.7% of children and 97.1% had received exclusive breastfeeding for up to 6 months. The factors associated with acute malnutrition were: the number of children ≥3 (pvalue = 0.001), non-consumption of vegetables (pvalue = 0.020), non-consumption of meat / offal / poultry (pvalue = 0.032), consumption of condiments / spices (pvalue = 0.000), presence of fever during the last weeks preceding the survey (pvalue = 0.010), non-washing of hands when leaving the toilet (pvalue = 0.010) and incomplete immunization status ( Pvalue = 0.00). The factors associated with chronic malnutrition were female sex (pvalue = 0.003), non-consumption of meat / offal / poultry (pvalue = 0.001), presence of diarrhoea during the last two weeks preceding the survey (pvalue = 0.021) and incomplete vaccination status (Pvalue = 0.000). The factors associated with underweight were: uneducated father (pvalue = 0.005), number of children ≥ 1 (pvalue = 0.028), lack of dietary diversification at 6 months (pvalu = 0.042), non-consumption of meat / offal / poultry (pvalue = 0.000), the presence of diarrhoea during the last weeks preceding the survey (pvalue = 0.001), and incomplete vaccination status (Pvalue = 0.000). Conclusion: The prevalence of deficiency malnutrition, whatever its form, remains high among children in Guédiawaye. Promoting good dietary practices, improving hygiene conditions and monitoring nutritional status in immunization units could help fight malnutrition.
{"title":"Prevalence and Factors Associated with Deficiency Malnutrition in the Health District of Guédiawaye, Senegal","authors":"Diouf Jbn, Sougou Nm, Tall Ct, K. M, Sarr Lp, N. O","doi":"10.33425/2689-1085.1021","DOIUrl":"https://doi.org/10.33425/2689-1085.1021","url":null,"abstract":"Introduction: Deficiency malnutrition poses a real public health problem, especially in developing countries. The objective of this study is to assess: (a) the prevalence of deficiency malnutrition in its various forms in children aged 6 - 59 months living in Guédiawaye and (b) its determinants. Materials and Methods: This descriptive and analytical cross-sectional study took place from September 1 to October 30, 2020 throughout the district of Guédiawaye in community. The study population consisted of children aged 6 - 59 months. Sampling with no survey was carried out and the total sample consisted of 603 subjects. Results: Twenty-nine point three percent (29.3%) of the children were acutely malnourished, 20.4% chronically malnourished, and 25.5% were underweight. Early breastfeeding was performed in 62.7% of children and 97.1% had received exclusive breastfeeding for up to 6 months. The factors associated with acute malnutrition were: the number of children ≥3 (pvalue = 0.001), non-consumption of vegetables (pvalue = 0.020), non-consumption of meat / offal / poultry (pvalue = 0.032), consumption of condiments / spices (pvalue = 0.000), presence of fever during the last weeks preceding the survey (pvalue = 0.010), non-washing of hands when leaving the toilet (pvalue = 0.010) and incomplete immunization status ( Pvalue = 0.00). The factors associated with chronic malnutrition were female sex (pvalue = 0.003), non-consumption of meat / offal / poultry (pvalue = 0.001), presence of diarrhoea during the last two weeks preceding the survey (pvalue = 0.021) and incomplete vaccination status (Pvalue = 0.000). The factors associated with underweight were: uneducated father (pvalue = 0.005), number of children ≥ 1 (pvalue = 0.028), lack of dietary diversification at 6 months (pvalu = 0.042), non-consumption of meat / offal / poultry (pvalue = 0.000), the presence of diarrhoea during the last weeks preceding the survey (pvalue = 0.001), and incomplete vaccination status (Pvalue = 0.000). Conclusion: The prevalence of deficiency malnutrition, whatever its form, remains high among children in Guédiawaye. Promoting good dietary practices, improving hygiene conditions and monitoring nutritional status in immunization units could help fight malnutrition.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91352686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benmassaoud Zineb, Bensatallah Tayeb, Ba Binta, M. Abdelhalim, Khattala Khalid, Bouabdallah Youssef
Introduction: Lipoblastoma is a rare form of a tumor. It is a benign tumor of embryonic adiposis tissue that primarily occurs in children younger than 3-years. Lipoblastoma is most located in the extremities and trunk. There is the focal circumscribed lipoblastoma and the infiltrating lipoblastoma. The management is complete surgical resection. Through a clinical description, we report the case of a lipoblastoma in a 7-month-old infant. The study aims to compare the clinical and outcome aspect with those in the literature. Case: A 7-old-month girl, who presents from birth a masse on the right trapezius muscle, fixed 8x 5 cm of large. No inflammatory signs in front of the tumor and no other location. We performed a total resection of the tumor and the pathology analysis found a lipoblastoma. After 2-years of follow-up, there is no recurrent tumor. The patient had no symptoms. Discussion: Lipoblastoma is a rare infant tumor with boy tendency. Another rare localization is reported as the neck, back, mesenteric, retroperitoneum, scrotum. CT scan and MRI can play a role in the possible preoperative assessment to evaluate the extent of the mass. In this particular localization, it is necessary to exclude any Intra medullar spinal extension. Surgical resection is the optimal treatment. Conclusion: Lipoblastoma is a rare tumor and has a good prognosis.
{"title":"Lipoblastoma Located on the Back: A Case of A 7-Month-Old Girl","authors":"Benmassaoud Zineb, Bensatallah Tayeb, Ba Binta, M. Abdelhalim, Khattala Khalid, Bouabdallah Youssef","doi":"10.33425/2689-1085.1017","DOIUrl":"https://doi.org/10.33425/2689-1085.1017","url":null,"abstract":"Introduction: Lipoblastoma is a rare form of a tumor. It is a benign tumor of embryonic adiposis tissue that primarily occurs in children younger than 3-years. Lipoblastoma is most located in the extremities and trunk. There is the focal circumscribed lipoblastoma and the infiltrating lipoblastoma. The management is complete surgical resection. Through a clinical description, we report the case of a lipoblastoma in a 7-month-old infant. The study aims to compare the clinical and outcome aspect with those in the literature. Case: A 7-old-month girl, who presents from birth a masse on the right trapezius muscle, fixed 8x 5 cm of large. No inflammatory signs in front of the tumor and no other location. We performed a total resection of the tumor and the pathology analysis found a lipoblastoma. After 2-years of follow-up, there is no recurrent tumor. The patient had no symptoms. Discussion: Lipoblastoma is a rare infant tumor with boy tendency. Another rare localization is reported as the neck, back, mesenteric, retroperitoneum, scrotum. CT scan and MRI can play a role in the possible preoperative assessment to evaluate the extent of the mass. In this particular localization, it is necessary to exclude any Intra medullar spinal extension. Surgical resection is the optimal treatment. Conclusion: Lipoblastoma is a rare tumor and has a good prognosis.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77703587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soares Reis Joana, Capela Mariana, Carriço Ana, Grenha Joana
We report a case of a patient admitted to the neonatal intensive care unit at birth for grunting and respiratory distress. A diagnosis was made after the patient presented with signs of serious poor perfusion and cardiorespiratory monitoring showed a rapid cardiac rhythm suggesting supraventricular tachycardia (SVT). Hemodynamic stability was achieved after several adenosine boluses and the SVT was reverted. Episodes of SVT are characterized by abrupt onset and termination and regular narrow QRS complex tachycardia without P waves. This diagnosis should be kept in mind in neonates when a sudden vascular change resembling cutis marmorata happens since it can suggest cardiogenic shock caused by an underlying arrhythmia.
{"title":"Neonatal Supraventricular Tachycardia- A Diagnostic Challenge","authors":"Soares Reis Joana, Capela Mariana, Carriço Ana, Grenha Joana","doi":"10.33425/2689-1085.1019","DOIUrl":"https://doi.org/10.33425/2689-1085.1019","url":null,"abstract":"We report a case of a patient admitted to the neonatal intensive care unit at birth for grunting and respiratory distress. A diagnosis was made after the patient presented with signs of serious poor perfusion and cardiorespiratory monitoring showed a rapid cardiac rhythm suggesting supraventricular tachycardia (SVT). Hemodynamic stability was achieved after several adenosine boluses and the SVT was reverted. Episodes of SVT are characterized by abrupt onset and termination and regular narrow QRS complex tachycardia without P waves. This diagnosis should be kept in mind in neonates when a sudden vascular change resembling cutis marmorata happens since it can suggest cardiogenic shock caused by an underlying arrhythmia.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77524412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Knee, Serena Knoop, A. Davis, Alisha DeBoer, Charito Madridejos, Jennifer Topiec
Objective: To evaluate the neurodevelopmental outcomes of very low birthweight (VLBW) infants before and after the introduction of a restrictive transfusion guideline. Study design: This is a large retrospective study comparing neurodevelopmental outcomes before and after a restrictive transfusion guideline (RTG) was established for VLBW infants admitted to a large single neonatal intensive care unit (NICU). Bayley-III scores obtained from routine NICU follow up appointments at pediatric neurodevelopmental clinics were evaluated. The mean age of obtaining the Bayley-III score was 20.3 months with a standard deviation of +/- 5.2 months. Results: Neurodevelopmental outcomes measured by Bayley-III scores, were similar for cognitive, language, and motor testing in the RTG versus LTG groups. In addition, the subcategories for normal, mild delay, moderate delay and severely delayed were also similar. Conclusion: RTG is safe in the neonatal VLBW population. RTG when compared to liberal transfusion guideline (LTG) is associated with similar neurodevelopmental outcomes as defined by Bayley-III scores.
{"title":"Neurologic Outcomes in Neonates Following the Introduction of a Restrictive Transfusion Guideline","authors":"D. Knee, Serena Knoop, A. Davis, Alisha DeBoer, Charito Madridejos, Jennifer Topiec","doi":"10.33425/2689-1085.1020","DOIUrl":"https://doi.org/10.33425/2689-1085.1020","url":null,"abstract":"Objective: To evaluate the neurodevelopmental outcomes of very low birthweight (VLBW) infants before and after the introduction of a restrictive transfusion guideline. Study design: This is a large retrospective study comparing neurodevelopmental outcomes before and after a restrictive transfusion guideline (RTG) was established for VLBW infants admitted to a large single neonatal intensive care unit (NICU). Bayley-III scores obtained from routine NICU follow up appointments at pediatric neurodevelopmental clinics were evaluated. The mean age of obtaining the Bayley-III score was 20.3 months with a standard deviation of +/- 5.2 months. Results: Neurodevelopmental outcomes measured by Bayley-III scores, were similar for cognitive, language, and motor testing in the RTG versus LTG groups. In addition, the subcategories for normal, mild delay, moderate delay and severely delayed were also similar. Conclusion: RTG is safe in the neonatal VLBW population. RTG when compared to liberal transfusion guideline (LTG) is associated with similar neurodevelopmental outcomes as defined by Bayley-III scores.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87878217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: To determine the correlation between tracheal amylase level and ventilator-associated pneumonia (VAP); and evaluate whether tracheal amylase level is associated with pre-intubation aspiration risk factors. Methods: This was a cohort study at Queen Sirikit National Institute of Child Health, Bangkok, Thailand, during April 2019 – March 2020. Intubated and mechanically ventilated pediatric patients aged 1mo – 15 years were included. Tracheal amylase levels were measured at time of enrollment and day of suspected VAP. Results: Tracheal amylase levels were measured at the time of enrollment and on the day of suspected VAP diagnosis. Eighty-eight patients were enrolled in this study, 22 (25%) of which were diagnosed as VAP; and 56 (63.6%) were male. Median initial amylase levels in non-VAP and VAP groups were 165.5 U/L and 108.5 U/L respectively (p=0.82). Median amylase level when VAP was diagnosed decreased to 63 U/L. Median initial amylase level significantly increased in patients with pre-intubation risk factors for aspiration compared to those without (320 U/L and 56 U/L respectively, p < 0.001). Conclusions: There was no association between initial tracheal amylase level and VAP but increased tracheal amylase level was associated with pre-intubation risk factors for aspiration.
前言:探讨气管淀粉酶水平与呼吸机相关性肺炎(VAP)的相关性;评估气管淀粉酶水平是否与插管前误吸危险因素相关。方法:这是一项队列研究，于2019年4月至2020年3月在泰国曼谷诗丽吉王后国立儿童健康研究所进行。包括年龄在1个月至15岁的插管和机械通气的儿童患者。在入组时和疑似VAP当日测量气管淀粉酶水平。结果:分别在入组时和疑似VAP诊断当日测量气管淀粉酶水平。88例患者入组，其中22例(25%)诊断为VAP;男性56例(63.6%)。非VAP组和VAP组初始淀粉酶水平中位数分别为165.5 U/L和108.5 U/L (p=0.82)。诊断为VAP时的中位淀粉酶水平降至63 U/L。插管前有误吸危险因素的患者初始淀粉酶水平中位数显著高于无危险因素的患者(分别为320 U/L和56 U/L, p < 0.001)。结论:气管初始淀粉酶水平与VAP无相关性，但气管淀粉酶水平升高与插管前误吸危险因素相关。
{"title":"Correlation of Tracheal Amylase and Ventilator-Associated Pneumonia in Mechanically Ventilated Pediatric Patients","authors":"K. Sitthikool, Sasitorn Supasad","doi":"10.33425/2689-1085.1018","DOIUrl":"https://doi.org/10.33425/2689-1085.1018","url":null,"abstract":"Introduction: To determine the correlation between tracheal amylase level and ventilator-associated pneumonia (VAP); and evaluate whether tracheal amylase level is associated with pre-intubation aspiration risk factors. Methods: This was a cohort study at Queen Sirikit National Institute of Child Health, Bangkok, Thailand, during April 2019 – March 2020. Intubated and mechanically ventilated pediatric patients aged 1mo – 15 years were included. Tracheal amylase levels were measured at time of enrollment and day of suspected VAP. Results: Tracheal amylase levels were measured at the time of enrollment and on the day of suspected VAP diagnosis. Eighty-eight patients were enrolled in this study, 22 (25%) of which were diagnosed as VAP; and 56 (63.6%) were male. Median initial amylase levels in non-VAP and VAP groups were 165.5 U/L and 108.5 U/L respectively (p=0.82). Median amylase level when VAP was diagnosed decreased to 63 U/L. Median initial amylase level significantly increased in patients with pre-intubation risk factors for aspiration compared to those without (320 U/L and 56 U/L respectively, p < 0.001). Conclusions: There was no association between initial tracheal amylase level and VAP but increased tracheal amylase level was associated with pre-intubation risk factors for aspiration.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84007377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bodnar Oleh, R. Aurel, Vatamanesku Livii, R. Roman, Kyrylyak Sergei, Shevtsiv Ivan
Background: Spinal dysraphism (SD) is a common birth defect resulting from incomplete closure of the neural tube during the first month of pregnancy. SD at children is difficult and unsolved problem in pediatric neurosurgery. Pathology of the lumbosacral area is 30% 50% of the total number of SD at children. Objective: To estimate the types, manifestation, complications and to determine the optimal terms and methods of surgical treatment of SD on lumbosacral area in infants. Methods: 23 infants with SD were operated. 3 were died after surgery. 20 children were assessed in follow up period (from 1 to 3 years). The children were operated at once after birth to 2 months. Depending on the anatomical variants of SD, the patients were divided into: meningocele (10%); meningoradiculocele (35%); myelomeningocele (30%), myelocystocele (5%) myeloschisis (20%). Findings: 8 children were operated from 1 to 2 days after birth. The best results for surgery were age of 8 days to 2 months (12 children). The late term of surgical operation was due to presence of hernia’s coats infection and purulence, which demanded the implementation of preoperative preparation. Cerebrospinal fluid leakage (7 children) has needed to urgent surgery. The disadvantage of all methods of surgical treatment of SD is the danger of damage to neural elements during surgery. Conclusion: During the execution of surgical treatment of SD is necessary to use radiculolysis with precision microsurgical excision of all cicatricial adhesions, cerebrospinal fluid cysts and other intraradicular formations and spinal canal’s revision. Dysfunction of the pelvic organs (urine and anal incontinence) in 75% and lower limbs in 40% that observed in children operated on SD in the neonatal period requires further development of methods of their surgical correction at the later age.
{"title":"Spinal Dysraphism of Lumbosacral Area in Infants: Aspects of Surgical Treatment","authors":"Bodnar Oleh, R. Aurel, Vatamanesku Livii, R. Roman, Kyrylyak Sergei, Shevtsiv Ivan","doi":"10.33425/2689-1085.1013","DOIUrl":"https://doi.org/10.33425/2689-1085.1013","url":null,"abstract":"Background: Spinal dysraphism (SD) is a common birth defect resulting from incomplete closure of the neural tube during the first month of pregnancy. SD at children is difficult and unsolved problem in pediatric neurosurgery. Pathology of the lumbosacral area is 30% 50% of the total number of SD at children. Objective: To estimate the types, manifestation, complications and to determine the optimal terms and methods of surgical treatment of SD on lumbosacral area in infants. Methods: 23 infants with SD were operated. 3 were died after surgery. 20 children were assessed in follow up period (from 1 to 3 years). The children were operated at once after birth to 2 months. Depending on the anatomical variants of SD, the patients were divided into: meningocele (10%); meningoradiculocele (35%); myelomeningocele (30%), myelocystocele (5%) myeloschisis (20%). Findings: 8 children were operated from 1 to 2 days after birth. The best results for surgery were age of 8 days to 2 months (12 children). The late term of surgical operation was due to presence of hernia’s coats infection and purulence, which demanded the implementation of preoperative preparation. Cerebrospinal fluid leakage (7 children) has needed to urgent surgery. The disadvantage of all methods of surgical treatment of SD is the danger of damage to neural elements during surgery. Conclusion: During the execution of surgical treatment of SD is necessary to use radiculolysis with precision microsurgical excision of all cicatricial adhesions, cerebrospinal fluid cysts and other intraradicular formations and spinal canal’s revision. Dysfunction of the pelvic organs (urine and anal incontinence) in 75% and lower limbs in 40% that observed in children operated on SD in the neonatal period requires further development of methods of their surgical correction at the later age.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73188272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ollandzobo Ikobo LC, Mongo Onkouo A, Ahombo Niotsebe EB, A. Clausina, Itoua Ngaporo NA, Mimiesse Mounanou JF, Atipo Ibara BI, Mabiala Babela JR, Deby-Gassaye Ibara JR
Objectives: To determine the prevalence of Helicobacter pylori infection in Brazzaville, to describe the epidemiological characteristics of infected children and to identify the factors favoring contamination. Patients and Methods: cross-sectional and analytical study for seven months in health centers in Brazzaville, based on the detection of the fecal antigen of Helicobacter pylori by qualitative immunochromatography from the stools of children whose age was between 2 and 17 years old. Results: The prevalence of helicobacter pylori infection in children was 38.36%. The female sex was predominant with a sex ratio of 1.76.The mean age of the children was 8.4 ± 4.39 years (range: 2 and 17 years). Children living in district 3 (Poto-Poto) were the most infected (P <0,000). Children between 5 and 9 years of age and those with primary education were the most infected ((P <0.05). The factors favoring contamination of Hp infection were the place of residence (p = 0.00), the age between 5-9 years (P <0.05), the age of the guardian between 35-44 years (P <0.03), the traditional type of latrine (P <0.05), the absence of hand washing before and after meals and after going to the toilet (p <0.05). Conclusion: Helicobacter pylori infection is common in children in Brazzaville. It is mainly the prerogative of young children. Factors favouring contamination are place of residence, age between 5-9 years, guardian’s age, type of latrine and lack of hand washing.
{"title":"Epidemiological Aspects of Helicobacter Pylori Infection in Children in Brazzaville","authors":"Ollandzobo Ikobo LC, Mongo Onkouo A, Ahombo Niotsebe EB, A. Clausina, Itoua Ngaporo NA, Mimiesse Mounanou JF, Atipo Ibara BI, Mabiala Babela JR, Deby-Gassaye Ibara JR","doi":"10.33425/2689-1085.1011","DOIUrl":"https://doi.org/10.33425/2689-1085.1011","url":null,"abstract":"Objectives: To determine the prevalence of Helicobacter pylori infection in Brazzaville, to describe the epidemiological characteristics of infected children and to identify the factors favoring contamination. Patients and Methods: cross-sectional and analytical study for seven months in health centers in Brazzaville, based on the detection of the fecal antigen of Helicobacter pylori by qualitative immunochromatography from the stools of children whose age was between 2 and 17 years old. Results: The prevalence of helicobacter pylori infection in children was 38.36%. The female sex was predominant with a sex ratio of 1.76.The mean age of the children was 8.4 ± 4.39 years (range: 2 and 17 years). Children living in district 3 (Poto-Poto) were the most infected (P <0,000). Children between 5 and 9 years of age and those with primary education were the most infected ((P <0.05). The factors favoring contamination of Hp infection were the place of residence (p = 0.00), the age between 5-9 years (P <0.05), the age of the guardian between 35-44 years (P <0.03), the traditional type of latrine (P <0.05), the absence of hand washing before and after meals and after going to the toilet (p <0.05). Conclusion: Helicobacter pylori infection is common in children in Brazzaville. It is mainly the prerogative of young children. Factors favouring contamination are place of residence, age between 5-9 years, guardian’s age, type of latrine and lack of hand washing.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79948340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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