S. Madièye, Sylva Barboza Firmin, Sarr Abdou, Kine Dione Fatou, Diatta Charlot, N. Mamadou, Ndiaye-Sy Awa, Yoro Sy Guata
{"title":"Anti-inflammatory and analgesic activities of methanolic extract of Elaeis guineensis Jacq. leaves (Arecaceae) and its fractions","authors":"S. Madièye, Sylva Barboza Firmin, Sarr Abdou, Kine Dione Fatou, Diatta Charlot, N. Mamadou, Ndiaye-Sy Awa, Yoro Sy Guata","doi":"10.5897/ajpp2022.5349","DOIUrl":"https://doi.org/10.5897/ajpp2022.5349","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44241142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ballo Mahamadou, T. Karim, D. Abdoulaye, A. D. Seidina, Dackouo Blaise, Ouéd raogo, Bah Sekou, Diakité Mahamadou, Sanogo Rokia, N. H. Y. Estelle
{"title":"In vitro inhibition of cyclooxygenases, anti-denaturation and antioxidant activities of Malian medicinal plants","authors":"Ballo Mahamadou, T. Karim, D. Abdoulaye, A. D. Seidina, Dackouo Blaise, Ouéd raogo, Bah Sekou, Diakité Mahamadou, Sanogo Rokia, N. H. Y. Estelle","doi":"10.5897/ajpp2022.5350","DOIUrl":"https://doi.org/10.5897/ajpp2022.5350","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44856096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tougoma Atèhèzi, Sagnan Atchrimi Komi, Victor Idah Oto-Obong, Umezuruike Egesie Gideon, Odu Odeh Samuel
{"title":"Acute and sub-acute toxicity evaluation of aqueous stem bark extract of Zanthoxylum Zanthoxyloides (Lam.) in male Albino Wistar rats","authors":"Tougoma Atèhèzi, Sagnan Atchrimi Komi, Victor Idah Oto-Obong, Umezuruike Egesie Gideon, Odu Odeh Samuel","doi":"10.5897/ajpp2022.5338","DOIUrl":"https://doi.org/10.5897/ajpp2022.5338","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47076398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adebayo Folaranmi Francis, Oluwadare Jegede Ayodapo, Isaac Adeyemi Oluwole
{"title":"Prevalence and possible psychoactive effects of hair cream use among students","authors":"Adebayo Folaranmi Francis, Oluwadare Jegede Ayodapo, Isaac Adeyemi Oluwole","doi":"10.5897/ajpp2022.5335","DOIUrl":"https://doi.org/10.5897/ajpp2022.5335","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49190442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José de Sousa Ferrão Elvino, Armando De Germano Janeque Edilson
Many studies have dealt with the medicinal properties of Jatropha curcas;however, there are limited studies on the scope of its antiviral potential. This is a fact associated with the current challenges posed by HIV-AIDS and COVID-19, which has reinforced the need to expand the knowledge about its antiviral resource. Based on the search for natural products with anti-HIV-1 and anti-SARS-CoV-2 activities, this work analyzed the extract of J. curcas seed, the structure of the plant whose antiviral references were not found in the literature, and the compounds that can potentiate it as a candidate for herbal medicine. GC-MS analysis was used to screen for the active substances of the J. curcas seeds, and the literature was searched to find those with anti-HIV-1 and anti-SARS-CoV-2 indication. The results showed they have 27 compounds, of which glycerol 1-palmitate, stigmasterol and gamma-sitosterol were shown to have antiviral action in the literature. Regarding glycerol 1-palmitate, no detailed description of its antiviral action was found. Stigmasterol and gamma-sitosterol act as anti-HIV-1 and anti-SARS-CoV-2, respectively, inhibiting the reverse transcriptase of HIV-1, the proteases 3CLpro, PLpro and the spike proteins of SARS-CoV-2. However, despite the fact that the extract of J. curcas seeds consist of antiviral compounds that fight against the etiological agents of HIV-AIDS and COVID-19, it is concluded that there is a need to deepen this evidence, by in vitro and in vivo assays.
{"title":"Anti-viral compounds from Jatropha curcas seed extract with anti-HIV-1 and anti-SARS-CoV-2 action","authors":"José de Sousa Ferrão Elvino, Armando De Germano Janeque Edilson","doi":"10.5897/ajpp2022.5328","DOIUrl":"https://doi.org/10.5897/ajpp2022.5328","url":null,"abstract":"Many studies have dealt with the medicinal properties of Jatropha curcas;however, there are limited studies on the scope of its antiviral potential. This is a fact associated with the current challenges posed by HIV-AIDS and COVID-19, which has reinforced the need to expand the knowledge about its antiviral resource. Based on the search for natural products with anti-HIV-1 and anti-SARS-CoV-2 activities, this work analyzed the extract of J. curcas seed, the structure of the plant whose antiviral references were not found in the literature, and the compounds that can potentiate it as a candidate for herbal medicine. GC-MS analysis was used to screen for the active substances of the J. curcas seeds, and the literature was searched to find those with anti-HIV-1 and anti-SARS-CoV-2 indication. The results showed they have 27 compounds, of which glycerol 1-palmitate, stigmasterol and gamma-sitosterol were shown to have antiviral action in the literature. Regarding glycerol 1-palmitate, no detailed description of its antiviral action was found. Stigmasterol and gamma-sitosterol act as anti-HIV-1 and anti-SARS-CoV-2, respectively, inhibiting the reverse transcriptase of HIV-1, the proteases 3CLpro, PLpro and the spike proteins of SARS-CoV-2. However, despite the fact that the extract of J. curcas seeds consist of antiviral compounds that fight against the etiological agents of HIV-AIDS and COVID-19, it is concluded that there is a need to deepen this evidence, by in vitro and in vivo assays.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44263533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. R. Elion, O. A. Etou, R. P. Boukongo, H. M. Mambeke, C. Morabandza, A. Abena
{"title":"Acute toxicity and laxative effect of the aqueous extract of the leaves Crossopteryx febrifuga (Benth) in rats","authors":"I. R. Elion, O. A. Etou, R. P. Boukongo, H. M. Mambeke, C. Morabandza, A. Abena","doi":"10.5897/ajpp2022.5339","DOIUrl":"https://doi.org/10.5897/ajpp2022.5339","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47966228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The National Department of Health identified the need for Universal Health Coverage, highlighting improved access to quality healthcare in South Africa.Clinical pharmacists play a vital role in various settings, including medication safety, therapeutic drug monitoring and antimicrobial stewardship. Healthcare-related key performance indicators measures quality that ensure accountability, improve patient safety and assist decision-making. To understand the perceptions of pharmacists regarding education, barriers and outcome measures on practices of clinical pharmacy, this study employed qualitative research, with focus-group discussions and in-depth interviews.Dialogue from interviews and focus-groups were audio-taped, transcribed and stored as MS- Word™ documents. NVivo® were utilised to identify themes.Pseudo-names ensured participant confidentiality.Ethics approval was obtained from the Sefako Makgatho University Research and Ethics committee, participating private-healthcare groups and Government Research Offices. Pharmacists were interviewed in eight provinces, identifying seven themes. The majority of pharmacists felt that notable differences exist between the scope of practice of ward- and clinical pharmacists. Most pharmacists did not know the definition of pharmaceutical care.The consensus was that clinical functions require more in-depth work than functions by general pharmacists. All pharmacists experienced barriers to performing their functions. Mostly outcome measures used by pharmacists pertain to antimicrobial stewardship, pharmacists felt that additional training is necessary to perform clinical functions. Clinical work is considered more intense and requires greater involvement in multidisciplinary teams. The study contributes to the state of clinical pharmacy in South Africa. It provides insight into the different levels of clinical pharmacy practice. The findings provide insights into the implementation of Clinical pharmacy services in developing countries
{"title":"Clinical Pharmacy in South Africa: Qualitative investigation of perspectives of practicing pharmacists","authors":"Bronkhorst Elmien, Schellack Natalie, GS Gous Andries","doi":"10.5897/ajpp2022.5329","DOIUrl":"https://doi.org/10.5897/ajpp2022.5329","url":null,"abstract":"The National Department of Health identified the need for Universal Health Coverage, highlighting improved access to quality healthcare in South Africa.Clinical pharmacists play a vital role in various settings, including medication safety, therapeutic drug monitoring and antimicrobial stewardship. Healthcare-related key performance indicators measures quality that ensure accountability, improve patient safety and assist decision-making. To understand the perceptions of pharmacists regarding education, barriers and outcome measures on practices of clinical pharmacy, this study employed qualitative research, with focus-group discussions and in-depth interviews.Dialogue from interviews and focus-groups were audio-taped, transcribed and stored as MS- Word™ documents. NVivo® were utilised to identify themes.Pseudo-names ensured participant confidentiality.Ethics approval was obtained from the Sefako Makgatho University Research and Ethics committee, participating private-healthcare groups and Government Research Offices. Pharmacists were interviewed in eight provinces, identifying seven themes. The majority of pharmacists felt that notable differences exist between the scope of practice of ward- and clinical pharmacists. Most pharmacists did not know the definition of pharmaceutical care.The consensus was that clinical functions require more in-depth work than functions by general pharmacists. All pharmacists experienced barriers to performing their functions. Mostly outcome measures used by pharmacists pertain to antimicrobial stewardship, pharmacists felt that additional training is necessary to perform clinical functions. Clinical work is considered more intense and requires greater involvement in multidisciplinary teams. The study contributes to the state of clinical pharmacy in South Africa. It provides insight into the different levels of clinical pharmacy practice. The findings provide insights into the implementation of Clinical pharmacy services in developing countries","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48617085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uchenna Agu Francis, Uche Elendu Melford, Kelechi Okechukwu Hope, Adolphus Mbah Chikodili, Chinonye Obioha Kennedy, Orji Abali Isaiah, E. Eghosa, Daniel Chukwu Nwachukwu and
Obesity is a global problem due to widespread consumption of high fat diet (HFD) with implications to well-being. This study was to investigate the modulatory effect of sibutramine and normal diet on obesity-induced alteration in kidney functions and adipokines in Wistar rats. Hundred rats were divided into four groups of 25 each and fed with either normal rat chow (NRC) (group I, control group, n=25) or HFD (n=75). Obese rats were subjected to treatment with HFD (group II, Obese + HFD, n=25), Sibutramine and NRC (group III, Obese + Sibutramine + NRC, n=25); and NRC (group IV, Obese + NRC, n=25) for another 12 weeks. Five rats from each group were sacrificed, urine and blood samples collected for baseline values after the acclimatization period. Similarly, at post induction, 4, 8 and 12 weeks urine and blood samples were collected from 5 rats per group for investigations. Induction of obesity significantly (p<0.05) increased mean Lee index, urine albumin, urine albumin:creatinine ratio, serum interleukin (IL)- 1β, IL -6, tumor necrotic factor (TNF)- α, interferon (IFN) - γ, leptin and decreased urine creatinine and serum adiponectin compared to control. Sibutramine treatment and withdrawal of HFD ameliorated these effects. Obesity induced renal impairment by deranging renal and inflammatory biomarkers investigated in this study. These adverse effects on the kidney were mitigated by sibutramine10 mg/kg/day and NRC by resisting the disturbance, thereby showing nephron-protective effect. The combined treatment of sibutramine with NRC reduced progression of kidney disease to a lesser extent than NRC alone suggesting nonsynergistic effect.
{"title":"Obesity related alterations in kidney function and plasma cytokines: Impact of sibutramine and diet in male Wistar rats","authors":"Uchenna Agu Francis, Uche Elendu Melford, Kelechi Okechukwu Hope, Adolphus Mbah Chikodili, Chinonye Obioha Kennedy, Orji Abali Isaiah, E. Eghosa, Daniel Chukwu Nwachukwu and","doi":"10.5897/ajpp2022.5305","DOIUrl":"https://doi.org/10.5897/ajpp2022.5305","url":null,"abstract":"Obesity is a global problem due to widespread consumption of high fat diet (HFD) with implications to well-being. This study was to investigate the modulatory effect of sibutramine and normal diet on obesity-induced alteration in kidney functions and adipokines in Wistar rats. Hundred rats were divided into four groups of 25 each and fed with either normal rat chow (NRC) (group I, control group, n=25) or HFD (n=75). Obese rats were subjected to treatment with HFD (group II, Obese + HFD, n=25), Sibutramine and NRC (group III, Obese + Sibutramine + NRC, n=25); and NRC (group IV, Obese + NRC, n=25) for another 12 weeks. Five rats from each group were sacrificed, urine and blood samples collected for baseline values after the acclimatization period. Similarly, at post induction, 4, 8 and 12 weeks urine and blood samples were collected from 5 rats per group for investigations. Induction of obesity significantly (p<0.05) increased mean Lee index, urine albumin, urine albumin:creatinine ratio, serum interleukin (IL)- 1β, IL -6, tumor necrotic factor (TNF)- α, interferon (IFN) - γ, leptin and decreased urine creatinine and serum adiponectin compared to control. Sibutramine treatment and withdrawal of HFD ameliorated these effects. Obesity induced renal impairment by deranging renal and inflammatory biomarkers investigated in this study. These adverse effects on the kidney were mitigated by sibutramine10 mg/kg/day and NRC by resisting the disturbance, thereby showing nephron-protective effect. The combined treatment of sibutramine with NRC reduced progression of kidney disease to a lesser extent than NRC alone suggesting nonsynergistic effect.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45730537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lahna Ali, Ez-zahir Abdeljaouad, Ndayambadje Martin, Limami Youness, Z. Younes, N. Abdallah, Oudghiri Mounia
Historically Artemisia herba alba (AHA) is widely used in traditional Moroccan medicine. Few studies have been carried out to confirm its traditional use, in particularly immunological studies and to the authors’ knowledge; no study has treated the in vivo immunomodulatory effect of AHA aqueous extracts. This work was established to assess the immunological effects of AHA, including the humoral and cellular immunity effects in vivo. The immunomodulatory effect was assessed by measuring the titer of specific antibodies by the agglutination technique after immunization of Wistar rats with sheep red blood cells, while the pro-inflammatory effect was performed using a carrageenan-induced rat paw edema model. Administered AHA’s aqueous extract (AE) appears to have significantly (p < 0.01) stimulated the production of anti-SRBC antibodies with a dose-dependent effect compared to the control. These results were confirmed by a significant increase in the levels of white blood cells in particular neutrophils, lymphocytes, monocytes and eosinophils (p<0.05) for the doses 0.5 and 1 g/ml/bw. For the same doses of the extract, a proinflammatory effect was observed by the size of edema and the presence of very dense inflammatory infiltrate made up of lymphocytes, plasma cells and polymorphonuclear neutrophils. The AHA’s AE have shown an important immunomodulatory and pro-inflammatory activities in vivo by enhancing the production of antibodies and the inflammatory reaction.
{"title":"In vivo studies of the immunomodulatory effect of aqueous extract of Artemisia herba alba","authors":"Lahna Ali, Ez-zahir Abdeljaouad, Ndayambadje Martin, Limami Youness, Z. Younes, N. Abdallah, Oudghiri Mounia","doi":"10.5897/ajpp2022.5304","DOIUrl":"https://doi.org/10.5897/ajpp2022.5304","url":null,"abstract":"Historically Artemisia herba alba (AHA) is widely used in traditional Moroccan medicine. Few studies have been carried out to confirm its traditional use, in particularly immunological studies and to the authors’ knowledge; no study has treated the in vivo immunomodulatory effect of AHA aqueous extracts. This work was established to assess the immunological effects of AHA, including the humoral and cellular immunity effects in vivo. The immunomodulatory effect was assessed by measuring the titer of specific antibodies by the agglutination technique after immunization of Wistar rats with sheep red blood cells, while the pro-inflammatory effect was performed using a carrageenan-induced rat paw edema model. Administered AHA’s aqueous extract (AE) appears to have significantly (p < 0.01) stimulated the production of anti-SRBC antibodies with a dose-dependent effect compared to the control. These results were confirmed by a significant increase in the levels of white blood cells in particular neutrophils, lymphocytes, monocytes and eosinophils (p<0.05) for the doses 0.5 and 1 g/ml/bw. For the same doses of the extract, a proinflammatory effect was observed by the size of edema and the presence of very dense inflammatory infiltrate made up of lymphocytes, plasma cells and polymorphonuclear neutrophils. The AHA’s AE have shown an important immunomodulatory and pro-inflammatory activities in vivo by enhancing the production of antibodies and the inflammatory reaction.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46952289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takoukam Christian Tenezogang, M. Tchamadeu, Zangueu Calvin Bogning, Patience Emambo, Nya Modeste Wankeu, A. Dongmo, Lembe Dieudonné Massoma
Angylocalyx oligophyllus (Fabaceae) is a shrub used traditionally to treat diabetes mellitus and intestinal parasites. Although it is also used by pregnant women, no scientific study has yet revealed its effects on pregnancy. This work aimed to assess the toxic effects of A. oligophyllus leaves aqueous extract on pregnancy, reproduction and fetal development in pregnant rats. The acute toxicity of the A. oligophyllus leaves aqueous extract was firstly performed in female non-pregnant rats. Then, pregnant rats were divided into a control and three test groups receiving, respectively distilled water and A. oligophyllus leaves aqueous extract doses (50, 100 and 200 mg/kg) by gavage for 20 days (from pregnancy screening day). The daily body masses of pregnant rats and the 21st-day relative organs masses were measured for assessing the pregnancy progress. The numbers of corpora lutea, implantation sites, live and dead fetuses and calculated pre-and-post implantation loss for appreciating the reproduction, and the fetuses’ masses for fetal development assessment, were recorded on the 21st day. Acute administration of the A. oligophyllus leaves aqueous extract (2000 mg/kg) did not cause any death or adverse effect in non-pregnant female rats. The LD 50 was estimated higher than 2000 mg/kg. Pregnancy and reproductive parameters did not vary significantly between plant extract-treated rats and control. However, although fetal development parameters did not change significantly between the groups, the percentages of small (SGA) and large (LGA) pups for the gestational age were higher in rats treated with the dose extract of 200 mg/kg, compared to control (20 and 11%, respectively). Current data showed that the A. oligophyllus leaves aqueous extract does not impair motherhood and reproduction. Nevertheless, limitation of the dose is recommended during treatment in pregnant women to avoid adverse effect on fetal development.
{"title":"Maternal-fetal repercussions of Angylocalyx oligophyllus leaves aqueous extract in pregnant rat","authors":"Takoukam Christian Tenezogang, M. Tchamadeu, Zangueu Calvin Bogning, Patience Emambo, Nya Modeste Wankeu, A. Dongmo, Lembe Dieudonné Massoma","doi":"10.5897/ajpp2021.5317","DOIUrl":"https://doi.org/10.5897/ajpp2021.5317","url":null,"abstract":"Angylocalyx oligophyllus (Fabaceae) is a shrub used traditionally to treat diabetes mellitus and intestinal parasites. Although it is also used by pregnant women, no scientific study has yet revealed its effects on pregnancy. This work aimed to assess the toxic effects of A. oligophyllus leaves aqueous extract on pregnancy, reproduction and fetal development in pregnant rats. The acute toxicity of the A. oligophyllus leaves aqueous extract was firstly performed in female non-pregnant rats. Then, pregnant rats were divided into a control and three test groups receiving, respectively distilled water and A. oligophyllus leaves aqueous extract doses (50, 100 and 200 mg/kg) by gavage for 20 days (from pregnancy screening day). The daily body masses of pregnant rats and the 21st-day relative organs masses were measured for assessing the pregnancy progress. The numbers of corpora lutea, implantation sites, live and dead fetuses and calculated pre-and-post implantation loss for appreciating the reproduction, and the fetuses’ masses for fetal development assessment, were recorded on the 21st day. Acute administration of the A. oligophyllus leaves aqueous extract (2000 mg/kg) did not cause any death or adverse effect in non-pregnant female rats. The LD 50 was estimated higher than 2000 mg/kg. Pregnancy and reproductive parameters did not vary significantly between plant extract-treated rats and control. However, although fetal development parameters did not change significantly between the groups, the percentages of small (SGA) and large (LGA) pups for the gestational age were higher in rats treated with the dose extract of 200 mg/kg, compared to control (20 and 11%, respectively). Current data showed that the A. oligophyllus leaves aqueous extract does not impair motherhood and reproduction. Nevertheless, limitation of the dose is recommended during treatment in pregnant women to avoid adverse effect on fetal development.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47887493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：