M. Abubakar, M. Dickson, C. E. Egwim, M. I. Bilkisu, Murtala, I. Lawal, B. Aliyu
P.M.B
下午B
{"title":"Characterization of native, acetylated and enzymatically modified amura starch (Tacca involucrata) for tablet binding","authors":"M. Abubakar, M. Dickson, C. E. Egwim, M. I. Bilkisu, Murtala, I. Lawal, B. Aliyu","doi":"10.5897/ajpp2021.5279","DOIUrl":"https://doi.org/10.5897/ajpp2021.5279","url":null,"abstract":"P.M.B","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41918146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study was to determine the knowledge base of traditional medicine practitioners (TMPs) in Benue State in relation to current good manufacturing practice for effective quality, safety, and increased economic value. A cross-sectional study was conducted among the TMPs using questionnaire. Information such as practice area, type of herbal medicine preparations, water quality, preservatives as well as knowledge of packaging of finished herbal medicines was evaluated. Over 55% of the TMPs practice herbal medicine alone, while others combine other traditional medicine disciplines alongside herbal medicine. Majority of the TMPs produce extemporaneous products for their patient while 10% produce products for sale. A number corresponding to 18% of the TMPs use either tap or borehole water, the others use water from well, streams and rivers. The herbal medicines produced by the TMPs are largely liquids and only 47% have any knowledge of preservatives and fewer have any knowledge on packaging of herbal medicines. This study shows that the majority of the TMPs lack appropriate technical resources and knowledge for herbal medicine production. Hence, there is an urgent need for a coordinated intervention in terms of working tools and trainings. water supply for the processing and preparation of the herbal medicines, preservatives used in herbal liquid preparations as well as packaging of the finished herbal medicines.
{"title":"Dynamics of herbal medicine processing and production in Benue State Nigeria","authors":"O. Adigwe, P. Builders, John Alfa, Peter Oladosu","doi":"10.5897/ajpp2022.5312","DOIUrl":"https://doi.org/10.5897/ajpp2022.5312","url":null,"abstract":"The aim of this study was to determine the knowledge base of traditional medicine practitioners (TMPs) in Benue State in relation to current good manufacturing practice for effective quality, safety, and increased economic value. A cross-sectional study was conducted among the TMPs using questionnaire. Information such as practice area, type of herbal medicine preparations, water quality, preservatives as well as knowledge of packaging of finished herbal medicines was evaluated. Over 55% of the TMPs practice herbal medicine alone, while others combine other traditional medicine disciplines alongside herbal medicine. Majority of the TMPs produce extemporaneous products for their patient while 10% produce products for sale. A number corresponding to 18% of the TMPs use either tap or borehole water, the others use water from well, streams and rivers. The herbal medicines produced by the TMPs are largely liquids and only 47% have any knowledge of preservatives and fewer have any knowledge on packaging of herbal medicines. This study shows that the majority of the TMPs lack appropriate technical resources and knowledge for herbal medicine production. Hence, there is an urgent need for a coordinated intervention in terms of working tools and trainings. water supply for the processing and preparation of the herbal medicines, preservatives used in herbal liquid preparations as well as packaging of the finished herbal medicines.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44752398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tinotenda Chanyandura Jonathan, Sai Poka Madan, Hulisani Demana Patrick, Autamashih Musa
About 50% of an oral dose of griseofulvin passes through the gastro-intestinal tract unabsorbed and is excreted in faeces. Short residence time of the low soluble griseofulvin, in stomach and small intestine, limits its dissolution. Griseofulvin is highly soluble in acidic pH, and so a gastro-retentive floating matrix system was developed to control dissolution rate and thereby enhance solubility to develop an improved and convenient dosage form. Preformulation studies included selection of excipients and evaluation of compatibility with griseofulvin. Tablets were prepared by wet granulation technique with varying ratios of Methocel™, Accurel MP and Polyvinylpyrrolidone as determined by Design Expert software. Buoyancy capability and dissolution studies were carried out to assess the influence of the tablet components. Tablets that float immediately upon contact with dissolution medium and continue floating for over 12 h were achieved with at least 28% of Accurel MP. An increase in tablet hardness reduced the rate of griseofulvin release only up to 120 min. Methocel™ had the most significant influence on griseofulvin release, with an indirect proportion to the rate of griseofulvin release. Using Design Expert software, optimized formulation was achieved with 1% Polyvinylpyrrolidone, 30% Methocel™, 60% Accurel MP and hardness ranging between 8 and 9 N. Tablets produced floated immediately upon contact with the medium and remained floating for at least 12 h. Griseofulvin was released from the optimized tablets in a near zero order fashion, with a total of 80.8% griseofulvin released at the end of the 12-h dissolution test period.
{"title":"Formulation and evaluation of gastro-retentive floating tablets of griseofulvin","authors":"Tinotenda Chanyandura Jonathan, Sai Poka Madan, Hulisani Demana Patrick, Autamashih Musa","doi":"10.5897/ajpp2022.5293","DOIUrl":"https://doi.org/10.5897/ajpp2022.5293","url":null,"abstract":"About 50% of an oral dose of griseofulvin passes through the gastro-intestinal tract unabsorbed and is excreted in faeces. Short residence time of the low soluble griseofulvin, in stomach and small intestine, limits its dissolution. Griseofulvin is highly soluble in acidic pH, and so a gastro-retentive floating matrix system was developed to control dissolution rate and thereby enhance solubility to develop an improved and convenient dosage form. Preformulation studies included selection of excipients and evaluation of compatibility with griseofulvin. Tablets were prepared by wet granulation technique with varying ratios of Methocel™, Accurel MP and Polyvinylpyrrolidone as determined by Design Expert software. Buoyancy capability and dissolution studies were carried out to assess the influence of the tablet components. Tablets that float immediately upon contact with dissolution medium and continue floating for over 12 h were achieved with at least 28% of Accurel MP. An increase in tablet hardness reduced the rate of griseofulvin release only up to 120 min. Methocel™ had the most significant influence on griseofulvin release, with an indirect proportion to the rate of griseofulvin release. Using Design Expert software, optimized formulation was achieved with 1% Polyvinylpyrrolidone, 30% Methocel™, 60% Accurel MP and hardness ranging between 8 and 9 N. Tablets produced floated immediately upon contact with the medium and remained floating for at least 12 h. Griseofulvin was released from the optimized tablets in a near zero order fashion, with a total of 80.8% griseofulvin released at the end of the 12-h dissolution test period.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46512705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gbongué Tia Eric, Ayoman Djadji Thierry-Lenoir, Sylvain Kouakou Landry, Tuo Karim, K. Etienne, Yacouba Adehouni Adebo, Awa Gniènèfèrètien Silue Nounaféri, Edith Ahou Kouadio Axelle, N. Geneviève, N’doua KOUAKOU-SIRANSY Gisèle
The study aimed to evaluate the in vivo antiplasmodial activity of an aqueous extract of aerial parts of Ipomoea pes-caprea in mice infected with Plasmodium berghei . Extracts of Ipomoea pes-caprea were obtained from the decoction of the dried leafy stem of the plant. The extracts obtained were used for the evaluation of the antiplasmodial activity which was done according to two methods: the Rane test was used to evaluate the curative effect of the aqueous extracts of Ipomoea pes-caprea while the Peters test was used for the suppressive effect. Four concentrations of the aqueous extract (25, 50, 100 and 200 mg/kg) were administered orally during the tests. The results showed a dose-dependent decrease in parasitaemia. The dose of 200 mg/kg bwt inhibited parasitaemia with a percentage suppression equal to 50.89% without resulting in significant body weight loss of the animals (p˃0.05), but showing a survival rate identical to that of chloroquine. This study showed that the aqueous extract of I. pes-caprea has antiplasmodial properties at the dose of 200 mg/kg bwt against P. berghei . It would be a good candidate to be tested in human parasite, that is, Plasmodium falciparum , for development of other antimalarial drugs.
{"title":"In vivo antiplasmodial activity of an aqueous extract of leafy stems of Ipomoea pes-caprea (L.) R.Br. in Swiss mice infected with Plasmodium berghei","authors":"Gbongué Tia Eric, Ayoman Djadji Thierry-Lenoir, Sylvain Kouakou Landry, Tuo Karim, K. Etienne, Yacouba Adehouni Adebo, Awa Gniènèfèrètien Silue Nounaféri, Edith Ahou Kouadio Axelle, N. Geneviève, N’doua KOUAKOU-SIRANSY Gisèle","doi":"10.5897/ajpp2022.5297","DOIUrl":"https://doi.org/10.5897/ajpp2022.5297","url":null,"abstract":"The study aimed to evaluate the in vivo antiplasmodial activity of an aqueous extract of aerial parts of Ipomoea pes-caprea in mice infected with Plasmodium berghei . Extracts of Ipomoea pes-caprea were obtained from the decoction of the dried leafy stem of the plant. The extracts obtained were used for the evaluation of the antiplasmodial activity which was done according to two methods: the Rane test was used to evaluate the curative effect of the aqueous extracts of Ipomoea pes-caprea while the Peters test was used for the suppressive effect. Four concentrations of the aqueous extract (25, 50, 100 and 200 mg/kg) were administered orally during the tests. The results showed a dose-dependent decrease in parasitaemia. The dose of 200 mg/kg bwt inhibited parasitaemia with a percentage suppression equal to 50.89% without resulting in significant body weight loss of the animals (p˃0.05), but showing a survival rate identical to that of chloroquine. This study showed that the aqueous extract of I. pes-caprea has antiplasmodial properties at the dose of 200 mg/kg bwt against P. berghei . It would be a good candidate to be tested in human parasite, that is, Plasmodium falciparum , for development of other antimalarial drugs.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41488476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Folorunsho Ayodele Peter, Fisayo Onifade Olayinka, Dada Williams Olawale, Stephen Omowaye Olaniyi, Olaide Salimon Mariam
Kidney is an essential organ responsible for excretion and detoxification. The use of streptozotocin in rat model experiments has provided rooms for researchers to test the effectiveness of medicinal plants that might possess nephroprotective and antidiabetic properties; so as to help in the treatment of diabetes complications. The study was aimed to evaluate the attenuating effects of ethanol extracts of Taminalia catappa leaves and Persea americana seed on renal damage associated with streptozotocin-induced diabetic rats. Thirty male wistar rats were randomly distributed into six groups (n = 5). Group 1: (Distilled water only); Group 2: 80 mg/kgbwt streptozotocin; Group 3: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt T. catappa leave extract); Group 4: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt Persea americana seed extract); Group 5: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt extracts-mixture); Group 6: (80 mg/kgbwt streptozotocin + 5 mg/kgbwt glibenclamide (standard drug). Streptozotocin was administered intraperitoneally, and glibenclamide orally. Blood sample was collected for biochemical analyses, and kidney for histopathology. Extracts of the T. catappa leaves and P. americana seed contributed significantly (p < 0.05) in bringing the levels of serum creatinine and urea; activities of alkaline phosphatase (ALP), alanine amino transferase (ALT) and aspartate amino transferase (AST) to normalcy. Both plant extracts equally produced significant (p < 0.05) regeneration of kidney cells.
{"title":"Ethanol extracts of Terminalia catappa leaves and Persea americana seed attenuate renal damage associated with Streptozotocin-induced diabetic rats","authors":"Folorunsho Ayodele Peter, Fisayo Onifade Olayinka, Dada Williams Olawale, Stephen Omowaye Olaniyi, Olaide Salimon Mariam","doi":"10.5897/ajpp2021.5250","DOIUrl":"https://doi.org/10.5897/ajpp2021.5250","url":null,"abstract":"Kidney is an essential organ responsible for excretion and detoxification. The use of streptozotocin in rat model experiments has provided rooms for researchers to test the effectiveness of medicinal plants that might possess nephroprotective and antidiabetic properties; so as to help in the treatment of diabetes complications. The study was aimed to evaluate the attenuating effects of ethanol extracts of Taminalia catappa leaves and Persea americana seed on renal damage associated with streptozotocin-induced diabetic rats. Thirty male wistar rats were randomly distributed into six groups (n = 5). Group 1: (Distilled water only); Group 2: 80 mg/kgbwt streptozotocin; Group 3: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt T. catappa leave extract); Group 4: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt Persea americana seed extract); Group 5: (80 mg/kgbwt streptozotocin + 200 mg/kgbwt extracts-mixture); Group 6: (80 mg/kgbwt streptozotocin + 5 mg/kgbwt glibenclamide (standard drug). Streptozotocin was administered intraperitoneally, and glibenclamide orally. Blood sample was collected for biochemical analyses, and kidney for histopathology. Extracts of the T. catappa leaves and P. americana seed contributed significantly (p < 0.05) in bringing the levels of serum creatinine and urea; activities of alkaline phosphatase (ALP), alanine amino transferase (ALT) and aspartate amino transferase (AST) to normalcy. Both plant extracts equally produced significant (p < 0.05) regeneration of kidney cells.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48046864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kasemnitichok Yosita, Chaijaroenkul Wanna, N. Kesara
Psoriasis is an incurable, chronic, recurrent immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells into the dermis and neovascularization. The study aimed to provide a systematic review on the in vitro, in vivo, and clinical studies to support traditional uses of herbal medicine for psoriasis treatment. The systematic review was performed by combining three databases, that is, PubMed, ScienceDirect, and Scopus, using the search terms “Psoriasis” AND “Herbal medicine” AND/OR “Traditional medicine.” Full-text articles included after the screening were further evaluated by applying the predefined eligibility criteria. One hundred and twenty research articles were included in the analysis. The included articles involve 94 herbs used as a single herbal extract (n=58 plants) or isolated compounds (n=54 compounds) or as compositions in traditional medicine formulas (n=24 formulas). Most were related to plants or recipes used in Traditional Chinese Medicine (TCM) (63 articles and 207 plants). Research targeting inflammatory and proliferative processes in disease pathogenesis, development, and progression has been an extensive area. The antipsoriasis activity of most plants was mainly through the effects on inflammatory molecules and signaling pathways and immune cells (T-cells, dendritic cells, monocytes, neutrophils, and macrophages), as well as apoptotic molecules and signaling pathways. Plants targeting other signaling molecules should be further investigated.
{"title":"Herbal medicine for psoriasis and their molecular targets: A systematic review","authors":"Kasemnitichok Yosita, Chaijaroenkul Wanna, N. Kesara","doi":"10.5897/ajpp2022.5292","DOIUrl":"https://doi.org/10.5897/ajpp2022.5292","url":null,"abstract":"Psoriasis is an incurable, chronic, recurrent immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells into the dermis and neovascularization. The study aimed to provide a systematic review on the in vitro, in vivo, and clinical studies to support traditional uses of herbal medicine for psoriasis treatment. The systematic review was performed by combining three databases, that is, PubMed, ScienceDirect, and Scopus, using the search terms “Psoriasis” AND “Herbal medicine” AND/OR “Traditional medicine.” Full-text articles included after the screening were further evaluated by applying the predefined eligibility criteria. One hundred and twenty research articles were included in the analysis. The included articles involve 94 herbs used as a single herbal extract (n=58 plants) or isolated compounds (n=54 compounds) or as compositions in traditional medicine formulas (n=24 formulas). Most were related to plants or recipes used in Traditional Chinese Medicine (TCM) (63 articles and 207 plants). Research targeting inflammatory and proliferative processes in disease pathogenesis, development, and progression has been an extensive area. The antipsoriasis activity of most plants was mainly through the effects on inflammatory molecules and signaling pathways and immune cells (T-cells, dendritic cells, monocytes, neutrophils, and macrophages), as well as apoptotic molecules and signaling pathways. Plants targeting other signaling molecules should be further investigated.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42827999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical Biology Laboratories, Health Ministry, P. O. Box 7022, Ouagadougou 03, Burkina Faso. 2School of Sciences, Health and Technologies, Saint Thomas d ́Aquin University, P. O. Box 10212, Ouagadougou 06, Burkina Faso. Laboratory of Molecular Biology, Epidemiology and Surveillance of Bacteria and Viruses Transmitted by Food (LaBESTA), Center for Research in Biological, Food and Nutritional Sciences (CRSBAN), Graduate School of Science and Technology (EDST), University Professor Joseph KI-ZERBO, Ouagadougou 03 BP 7021, Burkina Faso. Tengandogo Teaching Hospital, P. O. Box 104, Ouagadougou CMS 11, Burkina Faso. Souro Sanou University Hospital, Bobo-Dioulasso, Burkina Faso. Livestock National Laboratory, P. O. Box 907, Ouagadougou 09, Burkina Faso.
布基纳法索瓦加杜古03号，卫生部医学生物学实验室，邮政信箱7022。2科学、健康与技术学院，圣托马斯·德阿金大学，布基纳法索瓦加杜古06，邮政信箱10212。食品传播细菌和病毒的分子生物学、流行病学和监测实验室（LaBESTA），生物、食品和营养科学研究中心（CRSBAN），科学与技术研究生院（EDST），大学教授Joseph KI-ZERBO，瓦加杜古03 BP 7021，布基纳法索。Tengandogo教学医院，布基纳法索瓦加杜古CMS 11，邮政信箱104。Souro Sanou大学医院，布基纳法索波波迪乌拉索。畜牧业国家实验室，地址：布基纳法索瓦加杜古09，邮政信箱907。
{"title":"Knowledge, perception and beliefs of human health workers and veterinarians on antimicrobial resistance in Ouagadougou, Burkina Faso","authors":"Soré Souleymane, Bintou Josiane Diarra Fatimata, Sampo Emmanuel, Hamidou Ouandaogo Sandaogo, Salam Ouédraogo Abdoul, Sanou Idrissa","doi":"10.5897/ajpp2021.5290","DOIUrl":"https://doi.org/10.5897/ajpp2021.5290","url":null,"abstract":"Medical Biology Laboratories, Health Ministry, P. O. Box 7022, Ouagadougou 03, Burkina Faso. 2School of Sciences, Health and Technologies, Saint Thomas d ́Aquin University, P. O. Box 10212, Ouagadougou 06, Burkina Faso. Laboratory of Molecular Biology, Epidemiology and Surveillance of Bacteria and Viruses Transmitted by Food (LaBESTA), Center for Research in Biological, Food and Nutritional Sciences (CRSBAN), Graduate School of Science and Technology (EDST), University Professor Joseph KI-ZERBO, Ouagadougou 03 BP 7021, Burkina Faso. Tengandogo Teaching Hospital, P. O. Box 104, Ouagadougou CMS 11, Burkina Faso. Souro Sanou University Hospital, Bobo-Dioulasso, Burkina Faso. Livestock National Laboratory, P. O. Box 907, Ouagadougou 09, Burkina Faso.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45073736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antimalarial drug utilization pattern amongst staff of three health facilities in Rivers State, Nigeria","authors":"B. M. Bagbi, C. Ukwe, M. Adibe","doi":"10.5897/ajpp2021.5280","DOIUrl":"https://doi.org/10.5897/ajpp2021.5280","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48979827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. B. F. Laoula, A. Soma, Lamousa Paul Ouattara, Souleymane Sanon, J. Nikiéma, Khalid Ikiri, S. Sirima
In the crude extracts of the bark and leaves of Sclerocarya birrea , have been characterized sterols, triterpenes, saponosides, tannins, anthocyanosides, coumarins, reducing compounds, alkaloids and carotenoids. Tests were carried out in vitro with extracts from each part of the plant to assess their efficacy against strains of Plasmodium falciparum sensitive to chloroquine K1 and that resistant to chloroquine 3D7. The crude alkaloidal extracts of the bark gave IC50 = 2.54 μg / ml with the strain 3D7 and an IC50 = 4.09 μg / ml with the strain K1. On the other hand, the extracts with CH 2 Cl 2 showed an IC50 = 36.59 and 37.78 μg / ml respectively with the 3D7 and K1 strains. Those with CH 3 OH gave IC50 all greater than 50 μg/ml with both strains. The CH 3 OH / H 2 O extracts gave IC50 = 21.48 μg / ml with the K1 strain and greater than 50 μg / ml with 3D7. As for the H 2 O extracts, the IC50 were = 11.43 μg / ml with the K1 strain and also greater than 50 μg / ml with the 3D7. The alkaloid extracts of leaf gave an IC50 = 9.68 µg / ml with 3D7 and = 3.56 µg / ml with strain K1. With CH 2 Cl 2 , and IC50 = 6.62 μg / ml was obtained with 3D7 and 4.05 μg / ml with strain K1. The CH 3 OH extracts gave an IC50 = 21.12 μg / ml with the 3D7 strain and 21.06 μg / ml with the KI strain. The CH 3 OH / H 2 O extracts gave with strain 3D7 and IC50 of more than 50 and 32.73 μg / ml with K1. The aqueous extracts gave IC50 greater than 50 μg / ml for 3D7 and 25.17 μg / ml with the K1 strain.
{"title":"Antiplasmodial activities of leaves and trunk bark of Sclerocaria Birea (A. Ric H.) Hochst (Anacardiaceae), a plant used in traditional medicine of Niger","authors":"A. B. F. Laoula, A. Soma, Lamousa Paul Ouattara, Souleymane Sanon, J. Nikiéma, Khalid Ikiri, S. Sirima","doi":"10.5897/ajpp2021.5281","DOIUrl":"https://doi.org/10.5897/ajpp2021.5281","url":null,"abstract":"In the crude extracts of the bark and leaves of Sclerocarya birrea , have been characterized sterols, triterpenes, saponosides, tannins, anthocyanosides, coumarins, reducing compounds, alkaloids and carotenoids. Tests were carried out in vitro with extracts from each part of the plant to assess their efficacy against strains of Plasmodium falciparum sensitive to chloroquine K1 and that resistant to chloroquine 3D7. The crude alkaloidal extracts of the bark gave IC50 = 2.54 μg / ml with the strain 3D7 and an IC50 = 4.09 μg / ml with the strain K1. On the other hand, the extracts with CH 2 Cl 2 showed an IC50 = 36.59 and 37.78 μg / ml respectively with the 3D7 and K1 strains. Those with CH 3 OH gave IC50 all greater than 50 μg/ml with both strains. The CH 3 OH / H 2 O extracts gave IC50 = 21.48 μg / ml with the K1 strain and greater than 50 μg / ml with 3D7. As for the H 2 O extracts, the IC50 were = 11.43 μg / ml with the K1 strain and also greater than 50 μg / ml with the 3D7. The alkaloid extracts of leaf gave an IC50 = 9.68 µg / ml with 3D7 and = 3.56 µg / ml with strain K1. With CH 2 Cl 2 , and IC50 = 6.62 μg / ml was obtained with 3D7 and 4.05 μg / ml with strain K1. The CH 3 OH extracts gave an IC50 = 21.12 μg / ml with the 3D7 strain and 21.06 μg / ml with the KI strain. The CH 3 OH / H 2 O extracts gave with strain 3D7 and IC50 of more than 50 and 32.73 μg / ml with K1. The aqueous extracts gave IC50 greater than 50 μg / ml for 3D7 and 25.17 μg / ml with the K1 strain.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44912134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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