S. Kouakou, G. Yapo, A. Djadji, Y. Adéhouni, G. Kouakou-Siransy, G. Irié-N’guessan
{"title":"Effects of traditional remedy Sarenta and glibenclamide combination on hyperglycemia orally induced in rats","authors":"S. Kouakou, G. Yapo, A. Djadji, Y. Adéhouni, G. Kouakou-Siransy, G. Irié-N’guessan","doi":"10.5897/ajpp2023.5356","DOIUrl":"https://doi.org/10.5897/ajpp2023.5356","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49120317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Julius, Kaanyi Kirabo Mariam, John Mayoka Wilberforce, Namunyenga Rehema, Jaggwe Rogers, Imanirampa Lawrence, Tusiimire Jonans
Propolis is a resinous plant material collected by bees to defend their colony. This study evaluated the antibacterial and antioxidant activities of ethanolic extracts of Ugandan propolis in three bee-keeping agro-ecological zones. Antibacterial assays were performed on two Gram-positive ( S. aureus and S. pneumoniae ) and two Gram-negative ( E. coli and P. aeruginosa ) bacteria within a concentration range of ~1.6 to 100 mg/ml. Antioxidant assays were conducted spectrophotometrically on the basis of DCPIP reduction and the attendant decrease in absorbance at 605 nm wavelength. All extracts showed antibacterial activity against S. aureus with MICs ranging from 2.8 to 200 mg/ml, but P. aeruginosa displayed susceptibility only for samples from Western Highlands (MIC = 9.5 mg/ml). Of the Gram-negatives, E. coli was the more susceptible organism (MICs 5.7-31.5 mg/ml), but S. pneumoniae was susceptible only to samples from mid northern and Lake Victoria Crescent (MIC 34.6 mg/ml). Samples from Mid Northern region exhibited the highest antioxidant activity (mean ± SD activity equivalent to 20.4±4.3 µg of ascorbic acid per mg of extract), while those from Western Highlands exhibited the lowest (mean ± SD activity equivalent to 8.9 ± 2.5 µg of ascorbic acid per mg of extract). The antibacterial and antioxidant activities of propolis varied within and, more significantly, between the agro-ecological zones. Taken together, these results highlight the potential of Ugandan propolis as an antioxidant and antibacterial agent. Strategic selection of hive localities in zones that offer the best output in propolis should be a priority for bee-farmers.
{"title":"Variation of antioxidant and antibacterial activities of ethanolic extracts of propolis in three bee-keeping agro-ecological zones of Uganda","authors":"K. Julius, Kaanyi Kirabo Mariam, John Mayoka Wilberforce, Namunyenga Rehema, Jaggwe Rogers, Imanirampa Lawrence, Tusiimire Jonans","doi":"10.5897/ajpp2020.5193","DOIUrl":"https://doi.org/10.5897/ajpp2020.5193","url":null,"abstract":"Propolis is a resinous plant material collected by bees to defend their colony. This study evaluated the antibacterial and antioxidant activities of ethanolic extracts of Ugandan propolis in three bee-keeping agro-ecological zones. Antibacterial assays were performed on two Gram-positive ( S. aureus and S. pneumoniae ) and two Gram-negative ( E. coli and P. aeruginosa ) bacteria within a concentration range of ~1.6 to 100 mg/ml. Antioxidant assays were conducted spectrophotometrically on the basis of DCPIP reduction and the attendant decrease in absorbance at 605 nm wavelength. All extracts showed antibacterial activity against S. aureus with MICs ranging from 2.8 to 200 mg/ml, but P. aeruginosa displayed susceptibility only for samples from Western Highlands (MIC = 9.5 mg/ml). Of the Gram-negatives, E. coli was the more susceptible organism (MICs 5.7-31.5 mg/ml), but S. pneumoniae was susceptible only to samples from mid northern and Lake Victoria Crescent (MIC 34.6 mg/ml). Samples from Mid Northern region exhibited the highest antioxidant activity (mean ± SD activity equivalent to 20.4±4.3 µg of ascorbic acid per mg of extract), while those from Western Highlands exhibited the lowest (mean ± SD activity equivalent to 8.9 ± 2.5 µg of ascorbic acid per mg of extract). The antibacterial and antioxidant activities of propolis varied within and, more significantly, between the agro-ecological zones. Taken together, these results highlight the potential of Ugandan propolis as an antioxidant and antibacterial agent. Strategic selection of hive localities in zones that offer the best output in propolis should be a priority for bee-farmers.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46902372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahfoudhi Sarra, Gaies Emna, R. Charfi, Jebabli Nadia, Ben Sassi Mouna, EL Jebari Hanene, R. Daghfous, Trabelsi Sameh
{"title":"Relationship between vancomycin trough concentration and 24-h area under the curve concentration in Tunisian patients","authors":"Mahfoudhi Sarra, Gaies Emna, R. Charfi, Jebabli Nadia, Ben Sassi Mouna, EL Jebari Hanene, R. Daghfous, Trabelsi Sameh","doi":"10.5897/ajpp2022.5336","DOIUrl":"https://doi.org/10.5897/ajpp2022.5336","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46972988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tarnagda Grissoum, Ouédraogo Moussa, Charles Sombie Bavouma, Kouka Delma Luc, Nagaonle Quelques Eric, Claude Romaric Pingwende Ouedraogo Jean, Sombie Olivier, K. D. Maxime, Semdé Rasmané
{"title":"Assessment of pharmacy professionals knowledge and practice on the management and dispensing of investigational drugs in clinical trials","authors":"Tarnagda Grissoum, Ouédraogo Moussa, Charles Sombie Bavouma, Kouka Delma Luc, Nagaonle Quelques Eric, Claude Romaric Pingwende Ouedraogo Jean, Sombie Olivier, K. D. Maxime, Semdé Rasmané","doi":"10.5897/ajpp2022.5341","DOIUrl":"https://doi.org/10.5897/ajpp2022.5341","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43341491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdirahman Guled Bashir, Chiajaroenkul Wanna, N. Kesara
{"title":"Genetic diversity of pvcsp and pvs25 in Plasmodium vivax isolates in malaria-endemic areas in Asia, Africa, and America: A systematic review","authors":"Abdirahman Guled Bashir, Chiajaroenkul Wanna, N. Kesara","doi":"10.5897/ajpp2023.5355","DOIUrl":"https://doi.org/10.5897/ajpp2023.5355","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48022753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Misuse of antibiotics is the main cause for resistance development. The objective of this study is to assess patterns of antibiotics use and associated problems at Jimma Health Center. The study was conducted from February 25, 2016 to March 25, 2016. For the analysis of prescribing indicators retrospectively 295 patient charts that fulfills inclusion criteria were systematically selected from a total of 9800 charts from the health center registry department (from March 8, 2015 to March 25, 2016). Prospectively 120 patients were interviewed. The average number of drugs per encounter was 2.2 and percentage of encounter with antibiotics was 32%. 98.9% of medication was prescribed by their generic name and injection encounter was 9%. Amoxicillin was a commonly prescribed antibiotic during the study period (26%). The average consultation and dispensing time were 5.1 and 1.3 min, respectively and 73% of drugs dispensed were adequately labeled. There was a copy of Ethiopian essential drug list and standard treatment guidelines (STG - 2014). There was no drug formulary during the study period and some antibiotics were not available. Result of this study revealed prescribing practices and average number of drugs per prescription slightly deviate from World Health Organization standard. But generic and injection prescribing as well as use of Ethiopian essential drug list was not a problem.
{"title":"Assessment of antibiotics use and associated problems at Jimma Health Center, South West Ethiopia","authors":"Kinati Terfa Geremew, Zeleke Gemechu","doi":"10.5897/ajpp2019.5039","DOIUrl":"https://doi.org/10.5897/ajpp2019.5039","url":null,"abstract":"Misuse of antibiotics is the main cause for resistance development. The objective of this study is to assess patterns of antibiotics use and associated problems at Jimma Health Center. The study was conducted from February 25, 2016 to March 25, 2016. For the analysis of prescribing indicators retrospectively 295 patient charts that fulfills inclusion criteria were systematically selected from a total of 9800 charts from the health center registry department (from March 8, 2015 to March 25, 2016). Prospectively 120 patients were interviewed. The average number of drugs per encounter was 2.2 and percentage of encounter with antibiotics was 32%. 98.9% of medication was prescribed by their generic name and injection encounter was 9%. Amoxicillin was a commonly prescribed antibiotic during the study period (26%). The average consultation and dispensing time were 5.1 and 1.3 min, respectively and 73% of drugs dispensed were adequately labeled. There was a copy of Ethiopian essential drug list and standard treatment guidelines (STG - 2014). There was no drug formulary during the study period and some antibiotics were not available. Result of this study revealed prescribing practices and average number of drugs per prescription slightly deviate from World Health Organization standard. But generic and injection prescribing as well as use of Ethiopian essential drug list was not a problem.","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49029657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cannabis and regulatory science: A review of challenges in Africa","authors":"Zimunda Nyazema Norman","doi":"10.5897/ajpp2022.5334","DOIUrl":"https://doi.org/10.5897/ajpp2022.5334","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45788134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioactivities of Picrasma javanica Blume. leaf extract","authors":"S. Tasnuva, Rahman M. Shahidur","doi":"10.5897/ajpp2022.5340","DOIUrl":"https://doi.org/10.5897/ajpp2022.5340","url":null,"abstract":"","PeriodicalId":7531,"journal":{"name":"African Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44290644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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