Buru Ayuba Sunday, Mak Kit-Kay, Mohandas Kavitha, N. Vasanthakumari, Pichika Mallikarjuna Rao
{"title":"The Phytonutrients and Cytotoxicity Evaluation of Cinnamon Impressicostatum as Potential Antioxidant and Antibacterial in Food Supplement","authors":"Buru Ayuba Sunday, Mak Kit-Kay, Mohandas Kavitha, N. Vasanthakumari, Pichika Mallikarjuna Rao","doi":"10.36959/487/294","DOIUrl":"https://doi.org/10.36959/487/294","url":null,"abstract":"","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45333202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Jinchao, K. Susan, Yu Seok-Yeong, Tang Ying, Kim Young-Cheul, Chung Soonkyu, L. Zhenhua
A chronic low-grade inflammation is considered as a consequence of obesity, and linked with multiple complications. However, it is under-investigated how inflammatory cytokines mediate adipogenesis. This study investigated the role of Tumor Necrosis Factor α (TNF-α) on adipogenes is over high-fat diet feeding. Three groups of wild type or TNF-α-/mice with the same C57BL/6 genetic background were utilized in this study: wild type fed with a low-fat diet (WT-LFD), wild type fed with a high-fat diet (WT-HFD), and TNF-α-/fed with a HFD (TNF-HFD). After 16-wk feeding, inflammatory cytokine, Wnt pathway and adipogenesis-related genes were analyzed. HFD feeding increased body weight in both WTHFD and TNF-HFD groups, but genetic ablation of TNF-α attenuated HFD-induced obesity. In visceral adipose tissues, HFD elevated Wnt/β-catenin signaling, indicated by decreased phospho-GSK3β and active β-catenin, two key components within the Wnt pathway, and dysregulated adipogenesis, indicated by reduced PPARγ/CEBPα expressions. Whereas, the deletion of TNF-α suppressed Wnt-signaling, and restored expressions of adipogenes is-related genes, which were otherwise decreased in the HFD-induced obese animals. These findings demonstrated a critical role of TNF-α in the regulation of Wnt-signaling and adiposity in mice over a HFD feeding, indicating HFD-induced adipocyte dysfunction could be mitigated by targeting TNF-α and Wnt-signaling.
{"title":"The Genetic Ablation of TNF-α Attenuates Wnt-Signaling and Adiposity in High Fat Diet-Induced Obese Mice","authors":"Li Jinchao, K. Susan, Yu Seok-Yeong, Tang Ying, Kim Young-Cheul, Chung Soonkyu, L. Zhenhua","doi":"10.36959/487/290","DOIUrl":"https://doi.org/10.36959/487/290","url":null,"abstract":"A chronic low-grade inflammation is considered as a consequence of obesity, and linked with multiple complications. However, it is under-investigated how inflammatory cytokines mediate adipogenesis. This study investigated the role of Tumor Necrosis Factor α (TNF-α) on adipogenes is over high-fat diet feeding. Three groups of wild type or TNF-α-/mice with the same C57BL/6 genetic background were utilized in this study: wild type fed with a low-fat diet (WT-LFD), wild type fed with a high-fat diet (WT-HFD), and TNF-α-/fed with a HFD (TNF-HFD). After 16-wk feeding, inflammatory cytokine, Wnt pathway and adipogenesis-related genes were analyzed. HFD feeding increased body weight in both WTHFD and TNF-HFD groups, but genetic ablation of TNF-α attenuated HFD-induced obesity. In visceral adipose tissues, HFD elevated Wnt/β-catenin signaling, indicated by decreased phospho-GSK3β and active β-catenin, two key components within the Wnt pathway, and dysregulated adipogenesis, indicated by reduced PPARγ/CEBPα expressions. Whereas, the deletion of TNF-α suppressed Wnt-signaling, and restored expressions of adipogenes is-related genes, which were otherwise decreased in the HFD-induced obese animals. These findings demonstrated a critical role of TNF-α in the regulation of Wnt-signaling and adiposity in mice over a HFD feeding, indicating HFD-induced adipocyte dysfunction could be mitigated by targeting TNF-α and Wnt-signaling.","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49439935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-30DOI: 10.21776/UB.IJHN.2020.007.02.2
Firda Yusrina, Rani Puspitasari, T. Widyaningsih, Siti Narsito Wulan
ABSTRAK Prevalensi diabetes militus meningkat setiap tahunnya. Pisang mentah berpotensi sebagai pangan pengontrol gula darah karena mengandung pektin dan pati resisten (RS2). Kandungan pati resisten pada pisang dapat ditingkatkan dengan metode modifikasi fisik melalui proses perebusan dan pendinginan berulang untuk meningkatkan sifat resistensi pati termodifikasi (RS3) yang tahan terhadap suhu tinggi selama pemasakan. Tujuan penelitian ini untuk mengetahui pengaruh efek konsumsi tepung pisang mentah termodifikasi secara fisik (RS3) dibanding dengan tepung tanpa modifikasi tepung pisang mentah (RS2) dan pati jagung sebagai pati kontrol. Tikus dikelompokkan secara acak menjadi 3 group: kelompok 1 adalah kelompok pakan standart berdasarkan rekomendasi AIN-93 M yang mengandung pati jagung (kontrol). Tetapi kasein diganti menggunakan susu skim; kelompok 2 adalah kelompok pakan tepung pisang tidak dimodifikasi (RS2) dan kelompok 3 adalah kelompok pakan tepung pisang mentah modifikasi (RS3) sebagai pengganti pati jagung. Semua pakan diformulasi secara isokalori dan isoprotein. Pakan diberikan selama 15 hari. Hasil penelitian menunjukkan bahwa, pemberian pakan menggunakan tepung pisang modifikasi (RS3) cenderung menghasilkan kadar glukosa darah yang lebih rendah (P<0,05), kadar HDL lebih tinggi (P,0.05), kadar trigliserida darah lebih rendah (P,0.05). Nilai respon glikemik lebih rendah (P<0.05) dengan nilai AUC (daerah dibawah kurva) yang lebih rendah setelah meal tolerance test. Kata kunci : Diabetes Militus, Pati Resisten, Pengendalian Glukosa Darah, Pisang Mentah ABSTRACT The prevalence of diabetes mellitus increases every year. Unripe plantains have a potential as food that controls blood sugar due to their pectin and resistant starch (RS2) content. The content of resistant starch in plantains can be elevated by a physical modification method through a repeated boiling-cooling process to produce a more heat-stable resistant starch (RS3). The study aimed to determine the effect of consuming physically modified unripe plantain flour (RS3) compared with unmodified unripe plantain flour (RS2) and standard corn starch as control. Rats were randomly assigned into three groups; group 1 given a standard diet based on AIN-93M diet recommendation containing corn starch but the casein was replaced by skim milk powder, group 2 given unmodified unripe plantain flour (RS2), and group 3 given physically modified unripe plantain flour (RS3) as a substitute for corn starch. All diets were formulated as isocaloric and isoprotein. Diet interventions were provided for 15 days. The results showed that modified banana flour (RS3) feed tended to have lower blood glucose level (P <0.05), higher HDL level (P <0.05), lower blood triglyceride level (P <0.05), and lower glycemic response (P<0.05) indicated by a lower score of the area under the curve (AUC) following the meal tolerance test. Keywords: diabetes mellitus, resistant starch, blood glucose control, unripe pla
{"title":"Perbaikan Respon Glisemik dan Profil Lipid Setelah Mengkonsumsi Tepung Pisang Mentah Termodifikasi","authors":"Firda Yusrina, Rani Puspitasari, T. Widyaningsih, Siti Narsito Wulan","doi":"10.21776/UB.IJHN.2020.007.02.2","DOIUrl":"https://doi.org/10.21776/UB.IJHN.2020.007.02.2","url":null,"abstract":"ABSTRAK Prevalensi diabetes militus meningkat setiap tahunnya. Pisang mentah berpotensi sebagai pangan pengontrol gula darah karena mengandung pektin dan pati resisten (RS2). Kandungan pati resisten pada pisang dapat ditingkatkan dengan metode modifikasi fisik melalui proses perebusan dan pendinginan berulang untuk meningkatkan sifat resistensi pati termodifikasi (RS3) yang tahan terhadap suhu tinggi selama pemasakan. Tujuan penelitian ini untuk mengetahui pengaruh efek konsumsi tepung pisang mentah termodifikasi secara fisik (RS3) dibanding dengan tepung tanpa modifikasi tepung pisang mentah (RS2) dan pati jagung sebagai pati kontrol. Tikus dikelompokkan secara acak menjadi 3 group: kelompok 1 adalah kelompok pakan standart berdasarkan rekomendasi AIN-93 M yang mengandung pati jagung (kontrol). Tetapi kasein diganti menggunakan susu skim; kelompok 2 adalah kelompok pakan tepung pisang tidak dimodifikasi (RS2) dan kelompok 3 adalah kelompok pakan tepung pisang mentah modifikasi (RS3) sebagai pengganti pati jagung. Semua pakan diformulasi secara isokalori dan isoprotein. Pakan diberikan selama 15 hari. Hasil penelitian menunjukkan bahwa, pemberian pakan menggunakan tepung pisang modifikasi (RS3) cenderung menghasilkan kadar glukosa darah yang lebih rendah (P<0,05), kadar HDL lebih tinggi (P,0.05), kadar trigliserida darah lebih rendah (P,0.05). Nilai respon glikemik lebih rendah (P<0.05) dengan nilai AUC (daerah dibawah kurva) yang lebih rendah setelah meal tolerance test. Kata kunci : Diabetes Militus, Pati Resisten, Pengendalian Glukosa Darah, Pisang Mentah ABSTRACT The prevalence of diabetes mellitus increases every year. Unripe plantains have a potential as food that controls blood sugar due to their pectin and resistant starch (RS2) content. The content of resistant starch in plantains can be elevated by a physical modification method through a repeated boiling-cooling process to produce a more heat-stable resistant starch (RS3). The study aimed to determine the effect of consuming physically modified unripe plantain flour (RS3) compared with unmodified unripe plantain flour (RS2) and standard corn starch as control. Rats were randomly assigned into three groups; group 1 given a standard diet based on AIN-93M diet recommendation containing corn starch but the casein was replaced by skim milk powder, group 2 given unmodified unripe plantain flour (RS2), and group 3 given physically modified unripe plantain flour (RS3) as a substitute for corn starch. All diets were formulated as isocaloric and isoprotein. Diet interventions were provided for 15 days. The results showed that modified banana flour (RS3) feed tended to have lower blood glucose level (P <0.05), higher HDL level (P <0.05), lower blood triglyceride level (P <0.05), and lower glycemic response (P<0.05) indicated by a lower score of the area under the curve (AUC) following the meal tolerance test. Keywords: diabetes mellitus, resistant starch, blood glucose control, unripe pla","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"92-107"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43142959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRAK Hiperlipidemia merupakan penyebab dari berbagai penyakit degeneratif. Mengonsumsi air perasan lemon menjadi tren di Indonesia beberapa tahun ini. Pada penelitian ini, dilakukan perbandingan efektivitas air perasan lemon dan jeruk nipis. Tujuan dari penelitian ini adalah untuk menganalisis perbedaan profil lemak darah: kolesterol total, low density lipid (LDL), very low density lipoprotein (VLDL), dan trigliserida (TG) pada tikus yang diberi diet tinggi lemak, air perasan lemon, dan jeruk nipis. Penelitian ini menggunakan 32 tikus jantan galur Wistar yang dibagi menjadi 8 kelompok dosis perlakuan air perasan lemon dan jeruk nipis. Didapatkan hasil bahwa tidak ada perbedaan kadar LDL (P0.151; p<0.05), VLDL (P0.187; p<0.05), TG (P0.216; p<0.05), namun ditemukan perbedaan signifikan pada kadar kolesterol total (P0.003; p<0.05). Hewan coba yang diberi perlakuan jeruk nipis memiliki sebagian besar rerata kadar lemak yang tidak berbeda signifikan dengan kelompok perlakuan lemon. Meskipun demikian, kolesterol total pada kelompok jeruk nipis lebih rendah dibandingkan kelompok lemon. Konsumsi jeruk nipis tampaknya memiliki kemungkinan menjadi alternatif dari lemon yang lebih murah dan terjangkau untuk mencegah profil lemak yang buruk. Kata kunci : lemon, jeruk nipis, kolesterol total, LDL, VLDL, TG ABSTRACT Hyperlipidemia causes various degenerative diseases. Recently, consuming lemon juice has become a trend in Indonesia to improve blood lipid profiles. This study compared the effectiveness of lemon juice and lime juice. This study aimed to determine differences in blood lipid profile that contains total cholesterol (TC), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides (TG) in rats given High Fat Diet (HFD), lemon juice, and lime juice. This study used 32 white male Wistar rats (Rattus norvegicus) divided into eight treatment groups of lemon and lime juice doses. The results showed no significant differences in LDL (P0.151; p<0.05), VLDL (P0.187; p<0.05), and TG (P0.216; p<0.05), but there were significant differences in total cholesterol levels (P0.003; p<0.05). The experimental animals receiving lime juice had mean scores of lipid levels that were not significantly different from those with lemon treatment. However, the total cholesterol levels among groups given lime juice showed lower levels than the control and lemon treatment groups. Lime consumption seems possible to be a cheaper and affordable alternative to lemon to prevent lipid profile aberrations. Keywords: lemon, lime, TC, LDL, VLDL, TG
{"title":"Lime (Citrus aurantifolia (Christm.) Swingle) Juice Potential on Preventing Lipid Profile Aberrations as Alternative to Lemon (Citrus limon (L.) Burm.f.) Juice","authors":"Olivia Anggraeny, Keshya Venesa, N. Magdalena, Stefany Dame, Sylvia Winnie, Stephani Nesya, Nurdiana","doi":"10.21776/UB.IJHN.2020.007.02.7","DOIUrl":"https://doi.org/10.21776/UB.IJHN.2020.007.02.7","url":null,"abstract":"ABSTRAK Hiperlipidemia merupakan penyebab dari berbagai penyakit degeneratif. Mengonsumsi air perasan lemon menjadi tren di Indonesia beberapa tahun ini. Pada penelitian ini, dilakukan perbandingan efektivitas air perasan lemon dan jeruk nipis. Tujuan dari penelitian ini adalah untuk menganalisis perbedaan profil lemak darah: kolesterol total, low density lipid (LDL), very low density lipoprotein (VLDL), dan trigliserida (TG) pada tikus yang diberi diet tinggi lemak, air perasan lemon, dan jeruk nipis. Penelitian ini menggunakan 32 tikus jantan galur Wistar yang dibagi menjadi 8 kelompok dosis perlakuan air perasan lemon dan jeruk nipis. Didapatkan hasil bahwa tidak ada perbedaan kadar LDL (P0.151; p<0.05), VLDL (P0.187; p<0.05), TG (P0.216; p<0.05), namun ditemukan perbedaan signifikan pada kadar kolesterol total (P0.003; p<0.05). Hewan coba yang diberi perlakuan jeruk nipis memiliki sebagian besar rerata kadar lemak yang tidak berbeda signifikan dengan kelompok perlakuan lemon. Meskipun demikian, kolesterol total pada kelompok jeruk nipis lebih rendah dibandingkan kelompok lemon. Konsumsi jeruk nipis tampaknya memiliki kemungkinan menjadi alternatif dari lemon yang lebih murah dan terjangkau untuk mencegah profil lemak yang buruk. Kata kunci : lemon, jeruk nipis, kolesterol total, LDL, VLDL, TG ABSTRACT Hyperlipidemia causes various degenerative diseases. Recently, consuming lemon juice has become a trend in Indonesia to improve blood lipid profiles. This study compared the effectiveness of lemon juice and lime juice. This study aimed to determine differences in blood lipid profile that contains total cholesterol (TC), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides (TG) in rats given High Fat Diet (HFD), lemon juice, and lime juice. This study used 32 white male Wistar rats (Rattus norvegicus) divided into eight treatment groups of lemon and lime juice doses. The results showed no significant differences in LDL (P0.151; p<0.05), VLDL (P0.187; p<0.05), and TG (P0.216; p<0.05), but there were significant differences in total cholesterol levels (P0.003; p<0.05). The experimental animals receiving lime juice had mean scores of lipid levels that were not significantly different from those with lemon treatment. However, the total cholesterol levels among groups given lime juice showed lower levels than the control and lemon treatment groups. Lime consumption seems possible to be a cheaper and affordable alternative to lemon to prevent lipid profile aberrations. Keywords: lemon, lime, TC, LDL, VLDL, TG","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"153-163"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42300517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-03DOI: 10.21776/ub.ijhn.2020.007.01.5
Almira Nuraelah, Katrin Roosita, I. Ekayanti
Abstrak Air susu ibu (ASI) memiliki banyak manfaat dan dapat memenuhi kebutuhan gizi bayi selama periode 6 bulan pertama kehidupan. Produksi ASI pada ibu menyusui dapat ditingkatkan antara lain dengan konsumsi pangan laktogogum. Tujuan penelitian ini adalah mengetahui pengaruh pemberian cookies Galohgor yang mengandung laktagogum terhadap tingkat kecukupan dan status gizi bayi. Penelitian merupakan studi quasi eksperimental. Subjek penelitian merupakan 20 orang ibu postpartum di Kota Bogor. Subjek yang terpilih dikelompokkan menjadi kelompok kontrol (n=11) yang diberikan 40 g cookies tanpa penambahan galohgor dan kelompok cookies galohgor yang diberikan 40 g cookies yang mengandung galohgor selama 14 hari. Hasil penelitian menunjukkan bahwa tingkat kecukupan karbohidrat pada kelompok cookies galohgor lebih besar secara signifikan dibandingkan kelompok kontrol (124,9±32,6% vs. 90,8±31,1%, p 0,05). Sementara itu, hasil penelitian menunjukkan bb/u bayi pada kelompok galohgor secara signifikan lebih besar dibandingkan kelompok kontrol (3415,5±487,9 g vs. 3190±292,8 g, p<0,05). Hasil penelitian menunjukkan bahwa pemberian cookies galohgor berpengaruh terhadap tingkat kecukupan energi dan karbohidrat serta peningkatan berat bayi menurut umur. Kata kunci : berat badan bayi, lactagogum, galohgor, ibu postpartum, tingkat kecukupan bayi Abstract Breast milk has many benefits and fulfills the nutritional needs of infants in the first six months of life. Breast milk production of nursing mother could be boosted by consuming lactagogue. This study aimed to analyze the effect of Galohgor lactagogue cookies (GC) on nutrients adequacy level and nutritional status of infants. A quasi-experiment design was used in this study. Subjects of this study were 20 postpartum mothers in Bogor, West Java. The subjects were grouped into a control group (n = 11) given 40 g of cookies without galohgor and a galohgor cookies group given 40 g cookies containing galohgor for 14 days. The result showed that carbohydrate adequacy level of the galohgor cookies group was significantly higher than that in the control group (124.9 ± 32.6% vs 90.8 ± 31.1%, p<0.05). The results showed that weight-for-age was significantly associated with energy and carbohydrate adequacy levels of infants. The results showed that infant weight-for-age in the galohgor cookies group was significantly higher compared to that in the control group (3415.5 ± 487.9 g vs 3190 ± 292.8 g, p<0.05). These results suggested that galohgor cookies has a beneficial effect on energy intake and carbohydrate sufficiency and improve the weight-for-age of the infant. Keywords: nutrient adequacy, lactagogue, galohgor, postpartum mothers, weight for age
抽象的母乳有很多好处，可以在生命的前6个月为婴儿提供营养。母乳喂养的母乳生产可以通过食用拉克托古姆食品来增加。这项研究的目的是确定加洛赫古姆饼干对婴儿的舒适性和营养状况的影响。研究是一项实验quasi的研究。研究对象是茂物市20名产后妇女。被选中的受试者将被分成一个控制小组(n=11)，而不添加galohgor而给予40 g饼干，加lohgor饼干则给予40 g饼干，这些饼干含有galohgor 14天。研究结果表明,足够的碳水化合物水平组比对照组显著更大饼干galohgor(124.9±32,6% vs . 90.8±31,1%,p 0。05)。与此同时,研究结果展示bb -美国婴儿显著galohgor组比对照组(大3415.5±487.9 g vs . 3190±292.8 g, p < 0。05)。研究结果表明，加洛赫的饼干对能量和碳水化合物的充分性和婴儿体重的增加都有影响。关键词:婴儿的体重，lactagogum, galohgor，产后产妇，婴儿营养不良的发生率有很多好处，营养物质需要在最初6个月的生命中受精。母乳喂养母亲的乳汁生产可能被乳汁吞噬。这一研究表明，对营养水平和营养水平的影响进行了分析。这个研究中使用了一种准设计。这项研究的题目是20名死后母亲在西爪哇茂物。研究对象被归类为控制小组(n = 11)获得了没有galohgor的饼干40克，而galohgor饼干小组获得了40克饼干，再分配给galohgor 14天。论点那里的carbohydrate adequacy galohgor饼干之集团是significantly水平高很多学问》控制集团(124座9±32。6% vs 90。8月31±1%,p < 0 . 05)。最近的遗迹表明，这种千年性与能源和卡波西亚德有关。境results那里那个婴儿weight-for-age galohgor饼干集团是significantly高compared to that in The控制集团(3415 5±有487。9 g vs 3190±292。8 g, p < 0 . 05)。这些推荐的建议是，加洛赫热饼干对输氧和木质素产生了极大的影响，使营养水平升高。Keywords:营养不良，营养不良，加洛戈尔，产后母亲，体重
{"title":"Pengaruh Pemberian Cookies Galohgor terhadap Tingkat Kecukupan dan Status Gizi Bayi","authors":"Almira Nuraelah, Katrin Roosita, I. Ekayanti","doi":"10.21776/ub.ijhn.2020.007.01.5","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.5","url":null,"abstract":"Abstrak Air susu ibu (ASI) memiliki banyak manfaat dan dapat memenuhi kebutuhan gizi bayi selama periode 6 bulan pertama kehidupan. Produksi ASI pada ibu menyusui dapat ditingkatkan antara lain dengan konsumsi pangan laktogogum. Tujuan penelitian ini adalah mengetahui pengaruh pemberian cookies Galohgor yang mengandung laktagogum terhadap tingkat kecukupan dan status gizi bayi. Penelitian merupakan studi quasi eksperimental. Subjek penelitian merupakan 20 orang ibu postpartum di Kota Bogor. Subjek yang terpilih dikelompokkan menjadi kelompok kontrol (n=11) yang diberikan 40 g cookies tanpa penambahan galohgor dan kelompok cookies galohgor yang diberikan 40 g cookies yang mengandung galohgor selama 14 hari. Hasil penelitian menunjukkan bahwa tingkat kecukupan karbohidrat pada kelompok cookies galohgor lebih besar secara signifikan dibandingkan kelompok kontrol (124,9±32,6% vs. 90,8±31,1%, p 0,05). Sementara itu, hasil penelitian menunjukkan bb/u bayi pada kelompok galohgor secara signifikan lebih besar dibandingkan kelompok kontrol (3415,5±487,9 g vs. 3190±292,8 g, p<0,05). Hasil penelitian menunjukkan bahwa pemberian cookies galohgor berpengaruh terhadap tingkat kecukupan energi dan karbohidrat serta peningkatan berat bayi menurut umur. Kata kunci : berat badan bayi, lactagogum, galohgor, ibu postpartum, tingkat kecukupan bayi Abstract Breast milk has many benefits and fulfills the nutritional needs of infants in the first six months of life. Breast milk production of nursing mother could be boosted by consuming lactagogue. This study aimed to analyze the effect of Galohgor lactagogue cookies (GC) on nutrients adequacy level and nutritional status of infants. A quasi-experiment design was used in this study. Subjects of this study were 20 postpartum mothers in Bogor, West Java. The subjects were grouped into a control group (n = 11) given 40 g of cookies without galohgor and a galohgor cookies group given 40 g cookies containing galohgor for 14 days. The result showed that carbohydrate adequacy level of the galohgor cookies group was significantly higher than that in the control group (124.9 ± 32.6% vs 90.8 ± 31.1%, p<0.05). The results showed that weight-for-age was significantly associated with energy and carbohydrate adequacy levels of infants. The results showed that infant weight-for-age in the galohgor cookies group was significantly higher compared to that in the control group (3415.5 ± 487.9 g vs 3190 ± 292.8 g, p<0.05). These results suggested that galohgor cookies has a beneficial effect on energy intake and carbohydrate sufficiency and improve the weight-for-age of the infant. Keywords: nutrient adequacy, lactagogue, galohgor, postpartum mothers, weight for age","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44655529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-03DOI: 10.21776/ub.ijhn.2020.007.01.1
Enik Guntiyastutik, S. Sugiarto, Adi Magna Patriadi Nuhrawangsa
Abstrak Peningkatan kadar urea darah pada pasien penyakit ginjal kronis (PGK) dapat menyebabkan terjadinya disbiosis mikrobiota usus yang ditandai dengan penurunan bakteri sakarolitik dan peningkatan bakteri proteolitik yang menyebabkan semakin lamanya waktu transit feses dan terjadinya konstipasi. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian yoghurt dan soyghurt terhadap konsistensi feses pasien PGK dengan hemodialisis. Rancangan penelitian yang digunakan dalam penelitian ini adalah randomized control trial . Penelitian menggunakan 3 kelompok yaitu kontrol, intervensi yoghurt dan intervensi soyghurt. Subjek penelitian adalah 34 orang pasien PGK dengan hemodialisis, dengan kriteria inklusi: PGK stage 5, laki laki dan perempuan, usia 40-60 tahun, tidak mendapatkan terapi antibiotika selama minimal 21 hari, dan menjalani hemodialisis 2x/minggu. Data yang diperiksa dari responden adalah konsistensi feses pada awal dan akhir intervensi dengan menggunakan Bristol Tool Scale . Data ditabulasi dan dianalisis menggunakan Kruskall-Wallis dan Wilcoxon dengan SPSS for Windows. Pemberian yoghurt dan soyghurt selama 30 hari pada pasien PGK dengan hemodialisis melunakkan konsistensi feses secara bermakna, tetapi tidak ada perbedaan yang bermakna antara pemberian yoghurt dan soyghurt terhadap perubahan konsistensi feses. Sehingga dapat disimpulkan pemberian yoghurt atau soyghurt sama-sama memberikan efek terhadap perubahan konsistensi feses pasien PGK dengan hemodialisis. Kata kunci : penyakit ginjal kronis, hemodialisis, yoghurt, soyghurt Abstract The increase of blood urea level in patients with Chronic Kidney Disease (CKD) may lead to gut microbiota dysbiosis indicated by saccholytic bacteria reduction and proteolytic bacteria addition, which causes a longer transit time of feces and constipation. This study aimed to analyze the effect of yoghurt and soyghurt administration on the fecal consistency in CKD patients with hemodialysis. This study used Randomized Control Trial design. The study used three groups, namely control, yoghurt intervention, and soyghurt intervention. The research subjects were 31 patients with CKD who underwent hemodialysis at RSUD dr. Saiful Anwar Malang under the following criteria: stage five of CKD, male or female, aged 40-60 years, did not get antibiotic therapy for 21 days, and underwent hemodialysis 2 times/week. Data examined from respondents were the consistency of feces at the beginning and the end of the intervention used B ristol Tool S cale . Data were tabulated and analyzed using Kruskal-Wallis dan Wilcoxon test with SPSS for Windows. Administration of yoghurt and soyghurt for 30 days in CKD patients improved the fecal consistency of CKD patients with hemodialysis to be softer. In conclusion, both yoghurt and soyghurt could give the same effect on the fecal consistency of CKD patients with hemodialysis. Keywords: Chronic Kidney Disease, hemodialysis, yoghurt, soyghurt
摘要慢性肾脏病（CHP）患者血尿素水平升高可能导致肠道微生物群失调，其特征是囊溶菌和蛋白水解菌减少，从而增加转运期和便秘的持续时间。本研究旨在分析酸奶和大豆给药对PGK患者血液透析阶段一致性的影响。本研究采用的研究方案为随机对照试验。研究采用三组：对照组、酸奶干预组和大豆干预组。该研究包括34名接受血液透析的PGK患者，标准包括：PGK 5期，男性和女性，年龄40-60岁，至少21天未接受抗生素治疗，每周接受两次血液透析。响应者检查的数据是使用Bristol工具量表在干预开始和结束时阶段的一致性。使用Kruskall-Wallis和Wilcoxon以及SPSS for Windows收集和分析数据。PGK血液透析患者服用酸奶和大豆30天与粪便一致，但酸奶和大豆在粪便一致性变化方面没有显著差异。因此，酸奶或大豆可以联合给药，并对患者的PGK期与血液透析的一致性产生影响。关键词：慢性肾脏病、血液透析、酸奶、大豆摘要慢性肾脏病（CKD）患者血尿素水平升高可能导致肠道微生物群失调，表现为囊溶性细菌减少和蛋白水解性细菌增加，从而导致粪便转运时间变长和便秘。本研究旨在分析酸奶和大豆对血液透析CKD患者粪便稠度的影响。本研究采用随机对照试验设计。该研究采用了三组，即对照组、酸奶干预组和大豆干预组。研究对象为31名CKD患者，他们在RSUD Saiful Anwar Malang医生根据以下标准接受血液透析：CKD第五阶段，男性或女性，年龄40-60岁，21天内未接受抗生素治疗，每周接受2次血液透析。从受访者那里检查的数据是在干预开始和结束时粪便的一致性，使用B ristol工具S量表。使用Kruskal-Wallis和Wilcoxon检验以及SPSS for Windows对数据进行制表和分析。CKD患者服用酸奶和大豆30天可改善血液透析CKD患者的粪便稠度，使其更软。总之，酸奶和大豆对血液透析CKD患者粪便稠度的影响相同。关键词：慢性肾脏病；血液透析；酸奶；大豆
{"title":"Pengaruh Pemberian Yoghurt dan Soyghurt terhadap Konsistensi Feses Pasien Penyakit Ginjal Kronis dengan Hemodialisis","authors":"Enik Guntiyastutik, S. Sugiarto, Adi Magna Patriadi Nuhrawangsa","doi":"10.21776/ub.ijhn.2020.007.01.1","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.1","url":null,"abstract":"Abstrak Peningkatan kadar urea darah pada pasien penyakit ginjal kronis (PGK) dapat menyebabkan terjadinya disbiosis mikrobiota usus yang ditandai dengan penurunan bakteri sakarolitik dan peningkatan bakteri proteolitik yang menyebabkan semakin lamanya waktu transit feses dan terjadinya konstipasi. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian yoghurt dan soyghurt terhadap konsistensi feses pasien PGK dengan hemodialisis. Rancangan penelitian yang digunakan dalam penelitian ini adalah randomized control trial . Penelitian menggunakan 3 kelompok yaitu kontrol, intervensi yoghurt dan intervensi soyghurt. Subjek penelitian adalah 34 orang pasien PGK dengan hemodialisis, dengan kriteria inklusi: PGK stage 5, laki laki dan perempuan, usia 40-60 tahun, tidak mendapatkan terapi antibiotika selama minimal 21 hari, dan menjalani hemodialisis 2x/minggu. Data yang diperiksa dari responden adalah konsistensi feses pada awal dan akhir intervensi dengan menggunakan Bristol Tool Scale . Data ditabulasi dan dianalisis menggunakan Kruskall-Wallis dan Wilcoxon dengan SPSS for Windows. Pemberian yoghurt dan soyghurt selama 30 hari pada pasien PGK dengan hemodialisis melunakkan konsistensi feses secara bermakna, tetapi tidak ada perbedaan yang bermakna antara pemberian yoghurt dan soyghurt terhadap perubahan konsistensi feses. Sehingga dapat disimpulkan pemberian yoghurt atau soyghurt sama-sama memberikan efek terhadap perubahan konsistensi feses pasien PGK dengan hemodialisis. Kata kunci : penyakit ginjal kronis, hemodialisis, yoghurt, soyghurt Abstract The increase of blood urea level in patients with Chronic Kidney Disease (CKD) may lead to gut microbiota dysbiosis indicated by saccholytic bacteria reduction and proteolytic bacteria addition, which causes a longer transit time of feces and constipation. This study aimed to analyze the effect of yoghurt and soyghurt administration on the fecal consistency in CKD patients with hemodialysis. This study used Randomized Control Trial design. The study used three groups, namely control, yoghurt intervention, and soyghurt intervention. The research subjects were 31 patients with CKD who underwent hemodialysis at RSUD dr. Saiful Anwar Malang under the following criteria: stage five of CKD, male or female, aged 40-60 years, did not get antibiotic therapy for 21 days, and underwent hemodialysis 2 times/week. Data examined from respondents were the consistency of feces at the beginning and the end of the intervention used B ristol Tool S cale . Data were tabulated and analyzed using Kruskal-Wallis dan Wilcoxon test with SPSS for Windows. Administration of yoghurt and soyghurt for 30 days in CKD patients improved the fecal consistency of CKD patients with hemodialysis to be softer. In conclusion, both yoghurt and soyghurt could give the same effect on the fecal consistency of CKD patients with hemodialysis. Keywords: Chronic Kidney Disease, hemodialysis, yoghurt, soyghurt","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48548008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-03DOI: 10.21776/ub.ijhn.2020.007.01.6
Hanna Nurjanah, Budi Setiawan, Katrin Roosita
Abstrak Kelompok pra lansia dan lansia merupakan penderita diabetes terbanyak di Indonesia. Proses penuaan dapat menyebabkan kesulitan dalam proses makan. Modifikasi makanan menjadi bentuk cair membuat makanan lebih mudah untuk ditelan. Makanan tinggi serat direkomendasikan untuk penderita diabetes karena dapat meningkatkan kontrol glukosa darah. Labu kuning merupakan pangan sumber serat yang dimungkinkan dapat membantu menurunkan risiko perkembangan penyakit diabetes. Tujuan penelitian adalah membuat tepung labu kuning, mengembangkan formula makanan dalam bentuk cair dengan bahan dasar labu kuning, mengetahui karakteristik organoleptik, mutu gizi, dan viskositas formula. Penelitian ini menggunakan rancangan acak lengkap. Penyusunan formula berdasarkan jumlah tepung labu kuning, terdiri dari tiga formula yaitu F1(70 g), F2 (80 g), and F3 (90 g). Pengujian karakteristik organoleptik menggunakan skala hedonik. Panelis yang digunakan merupakan panelis semi terlatih. Kadar air, abu, protein, lemak, dan karbohidrat menggunakan analisis proksimat, kadar serat pangan menggunakan metode enzimatis dan viskositas menggunakan viskometer. Hasil penilaian hedonik menunjukkan bahwa formula F3 merupakan formula terpilih. Formula terpilih memiliki kadar air 86,06%, abu 0,49%, protein 1,42%, lemak 1,18%, karbohidrat 10,85%, serat pangan 5,81%, dan viskositas 6,5 cP. Formula labu kuning berpotensi sebagai makanan alternatif untuk penderita diabetes karena memiliki serat tinggi. Kata kunci : diabetes, makanan bentuk cair, serat pangan, tepung labu kuning Abstract The highest diabetic population in Indonesia are among the pre-elderly and elderly age groups. Aging process could cause difficulties in eating. Modifying food into the liquid form will make food easier to swallow. High-fiber food is recommended for people with diabetes because it improves blood glucose control. Pumpkin is a food source rich in fiber that is possible to help to reduce the risk of diabetes development. This research aimed to produce pumpkin flour, develop a food formula in liquid form made from pumpkin, and determine the organoleptic characteristics, nutrition content, and viscosity of the formula. This study used a complete randomized design. The formulation was based on the amount of pumpkin flour that consists of three formulas; F1(70 g), F2 (80 g), and F3 (90 g). The organoleptic characteristic test was done using a hedonic scale. The panelists involved were semi-trained panelists. The analysis on water, ash, protein, lipid and carbohydrate levels was done using proximate analysis, the dietary fiber level was using the enzymatic method, and viscosity measurement was using a viscometer. According to hedonic assessment results, the selected formula was F3. The selected formula has 86.06% water, 0.49% ash, 1.42% protein, 1.18% fat, 10.85% carbohydrate, 5.81% dietary fiber, and 6.5 cP of viscosity. Yellow pumpkin formula has the potency as the alternative food for people with diabetes becau
Pre-Advanced and Advanced Group是印度尼西亚最大的糖尿病患者。衰老会导致进食困难。把食物改成液体会使食物更容易吃。建议糖尿病患者食用高纤维食物，因为它们可以提高血糖控制。黄蜘蛛可能是昆虫的饲料，有助于降低患糖尿病的风险。本研究的目的是制作黄蜘蛛粉，以黄蜘蛛为原料开发液体食品配方，了解其感官特性、颗粒静音性和配方粘度。本研究采用完全随机设计。根据黄色南瓜片的数量排列的配方由三个配方组成：F1（70克）、F2（80克）和F3（90克）。使用享乐量表测试感官特征。所使用的面板是经过半训练的面板。使用近似分析的水、灰分、蛋白质、脂肪和碳水化合物的比率，使用酶法的昆虫比率和使用粘度计的粘度。特征评估的结果表明，公式F3是所选择的公式。所选配方的含水量为86.06%，灰分为0.49%，蛋白质为1.42%，脂肪为1.18%，碳水化合物为10.85%，草莓为5.81%，粘度为6.5cP。黄蜘蛛配方可能是糖尿病患者的替代食品，因为它具有高纤维。关键词：糖尿病、流质食品、草莓、黄辣椒汁摘要印度尼西亚糖尿病发病率最高的人群是老年前期和老年组。衰老过程可能导致进食困难。把食物改成液体会使食物更容易吞咽。建议糖尿病患者食用高纤维食物，因为它可以改善血糖控制。南瓜是一种富含纤维的食物来源，有助于降低患糖尿病的风险。本研究旨在生产南瓜粉，开发以南瓜为原料的液态食品配方，并测定配方的感官特性、营养含量和粘度。本研究采用完全随机设计。配方基于南瓜粉的量，南瓜粉由三种配方组成F1（70克）、F2（80克）和F3（90克）。感官特征测试是使用享乐量表进行的。参与的小组成员都是经过半培训的小组成员。水、灰分、蛋白质、脂质和碳水化合物水平的分析采用近似分析法，膳食纤维水平采用酶法，粘度测量采用粘度计。根据特征评估结果，选择的公式为F3。所选配方含有86.06%的水、0.49%的灰分、1.42%的蛋白质、1.18%的脂肪、10.85%的碳水化合物、5.81%的膳食纤维和6.5cP的粘度。黄南瓜配方因其高膳食纤维而成为糖尿病患者的替代食品。关键词：糖尿病、膳食纤维、食品液体、南瓜粉
{"title":"Potensi Labu Kuning (Cucurbita moschata) sebagai Makanan Tinggi Serat dalam Bentuk Cair","authors":"Hanna Nurjanah, Budi Setiawan, Katrin Roosita","doi":"10.21776/ub.ijhn.2020.007.01.6","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.6","url":null,"abstract":"Abstrak Kelompok pra lansia dan lansia merupakan penderita diabetes terbanyak di Indonesia. Proses penuaan dapat menyebabkan kesulitan dalam proses makan. Modifikasi makanan menjadi bentuk cair membuat makanan lebih mudah untuk ditelan. Makanan tinggi serat direkomendasikan untuk penderita diabetes karena dapat meningkatkan kontrol glukosa darah. Labu kuning merupakan pangan sumber serat yang dimungkinkan dapat membantu menurunkan risiko perkembangan penyakit diabetes. Tujuan penelitian adalah membuat tepung labu kuning, mengembangkan formula makanan dalam bentuk cair dengan bahan dasar labu kuning, mengetahui karakteristik organoleptik, mutu gizi, dan viskositas formula. Penelitian ini menggunakan rancangan acak lengkap. Penyusunan formula berdasarkan jumlah tepung labu kuning, terdiri dari tiga formula yaitu F1(70 g), F2 (80 g), and F3 (90 g). Pengujian karakteristik organoleptik menggunakan skala hedonik. Panelis yang digunakan merupakan panelis semi terlatih. Kadar air, abu, protein, lemak, dan karbohidrat menggunakan analisis proksimat, kadar serat pangan menggunakan metode enzimatis dan viskositas menggunakan viskometer. Hasil penilaian hedonik menunjukkan bahwa formula F3 merupakan formula terpilih. Formula terpilih memiliki kadar air 86,06%, abu 0,49%, protein 1,42%, lemak 1,18%, karbohidrat 10,85%, serat pangan 5,81%, dan viskositas 6,5 cP. Formula labu kuning berpotensi sebagai makanan alternatif untuk penderita diabetes karena memiliki serat tinggi. Kata kunci : diabetes, makanan bentuk cair, serat pangan, tepung labu kuning Abstract The highest diabetic population in Indonesia are among the pre-elderly and elderly age groups. Aging process could cause difficulties in eating. Modifying food into the liquid form will make food easier to swallow. High-fiber food is recommended for people with diabetes because it improves blood glucose control. Pumpkin is a food source rich in fiber that is possible to help to reduce the risk of diabetes development. This research aimed to produce pumpkin flour, develop a food formula in liquid form made from pumpkin, and determine the organoleptic characteristics, nutrition content, and viscosity of the formula. This study used a complete randomized design. The formulation was based on the amount of pumpkin flour that consists of three formulas; F1(70 g), F2 (80 g), and F3 (90 g). The organoleptic characteristic test was done using a hedonic scale. The panelists involved were semi-trained panelists. The analysis on water, ash, protein, lipid and carbohydrate levels was done using proximate analysis, the dietary fiber level was using the enzymatic method, and viscosity measurement was using a viscometer. According to hedonic assessment results, the selected formula was F3. The selected formula has 86.06% water, 0.49% ash, 1.42% protein, 1.18% fat, 10.85% carbohydrate, 5.81% dietary fiber, and 6.5 cP of viscosity. Yellow pumpkin formula has the potency as the alternative food for people with diabetes becau","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"54-68"},"PeriodicalIF":0.0,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49342453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food insecurity is defined as situation that exists when all people, at all times, have no physical, social and economic access to sufficient, safe and nutritious food that meets their dietary needs and food preferences for an active and healthy life. Fish farming plays an important role in food security and nutrition by providing food and income. The aim of this study was to assess household food insecurity status and nutritional status of under-five children and women of reproductive age from pond fish farming households in Sidama Zone, Southern Ethiopia.
{"title":"Household Food Insecurity and Nutritional Status of Under-Five Children and Women of Reproductive Age from Pond Fish Farming Households in Sidama Zone, Southern Ethiopia: Community Based Cross-Sectional Study","authors":"Y. Kifle","doi":"10.36959/487/289","DOIUrl":"https://doi.org/10.36959/487/289","url":null,"abstract":"Food insecurity is defined as situation that exists when all people, at all times, have no physical, social and economic access to sufficient, safe and nutritious food that meets their dietary needs and food preferences for an active and healthy life. Fish farming plays an important role in food security and nutrition by providing food and income. The aim of this study was to assess household food insecurity status and nutritional status of under-five children and women of reproductive age from pond fish farming households in Sidama Zone, Southern Ethiopia.","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43944180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstrak Kebutuhan akan kesehatan diharapkan pada semua orang, namun kesehatan harus perlu dijaga agar tidak terpapar adanya radikal bebas yang berlebihan, karena akan memicu timbulnya penyakit diabetes mellitus disertai adanya peningkatan kadar malondehaldehid. Pencegahan radikal bebas yang berlebihan dapat memanfaatkan biji Cucurbita moschata . Antioksidan pada biji Cucurbita moschata berperan dalam mengatasi dan mencegah adanya stres oksidatif pada penderita diabetes mellitus. Penelitian bertujuan untuk mengetahui potensi ekstrak etanol biji Cucurbita moschata terhadap kadar malondehaldehid mencit model diabetes. Metode penelitian eksperimental dengan desain post test control group design , mencit jantan sebanyak 24 ekor umur 1 bulan dengan berat badan 20-30 gram, dibagi menjadi 6 kelompok: kontrol negatif, kontrol positif, kontrol metformin, dan kelompok perlakuan ekstrak etanol biji Cucurbita moschata dosis 180, 360 dan 720 mg/kg BB diberikan secara sonde oral selama 14 hari. Pengamatan terhadap kadar malondehaldehid. Hasil penelitian pemberian ekstrak etanol biji Cucurbita moschata pada semua dosis kelompok perlakuan dapat menurunkan kadar malondehaldehid (Kruskal Wallis p 0,04 < 0,05), sedangkan dosis yang lebih efektif sebanyak 360 mg/kgBB. Kesimpulan semua dosis kelompok perlakuan dapat menurunkan kadar malondehaldehid, sedangkan dosis yang lebih efektif sebanyak 360 mg/kgBB. Kata kunci : Cucurbita moschata, malondehaldehid, diabetes Abstract Everybody expects of being healthy, but health must be maintained to avoid excessive free radical exposure since it will trigger the onset of diabetes mellitus that is accompanied by an increase in the malondialdehyde level. Prevention of excessive free radicals can be done by utilizing Cucurbita moschata seeds. Antioxidants in Cucurbita moschata seeds play a role in overcoming and preventing oxidative stress in people with diabetes mellitus. The study aimed to determine the potential of ethanol extract of Cucurbita moschata seeds on the malondialdehyde level in diabetic mice. This study applied an experimental research method with a posttest control group design. The subjects were 24 male mice aged one month with a bodyweight of 20-30 grams and were divided into six groups: negative control, positive control, metformin control, and treatment groups of ethanol extract Cucurbita moschata seed doses of 180, 360, and 720 mg/kgBW given orally for 14 days. The results of the study showed that ethanol extract of Cucurbita moschata seeds on all treatment doses could reduce the malondialdehyde level (Kruskal Wallis p 0.04 <0.05), but the most effective dose was 360 mg/kgBW. In short, all treatment doses can reduce the malondialdehyde level, but the most effective dose is 360 mg/kgBW. Keywords: Cucurbita moschata, malondialdehyde , diabetes
{"title":"Potensi Ekstrak Etanol Biji Cucurbita moschata terhadap Kadar Malondehaldehid Mencit Model Diabetes","authors":"Suwanto Suwanto, Mono Pratiko Gustomi, Rochmah Kurnijasanti","doi":"10.21776/ub.ijhn.2020.007.01.3","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.3","url":null,"abstract":"Abstrak Kebutuhan akan kesehatan diharapkan pada semua orang, namun kesehatan harus perlu dijaga agar tidak terpapar adanya radikal bebas yang berlebihan, karena akan memicu timbulnya penyakit diabetes mellitus disertai adanya peningkatan kadar malondehaldehid. Pencegahan radikal bebas yang berlebihan dapat memanfaatkan biji Cucurbita moschata . Antioksidan pada biji Cucurbita moschata berperan dalam mengatasi dan mencegah adanya stres oksidatif pada penderita diabetes mellitus. Penelitian bertujuan untuk mengetahui potensi ekstrak etanol biji Cucurbita moschata terhadap kadar malondehaldehid mencit model diabetes. Metode penelitian eksperimental dengan desain post test control group design , mencit jantan sebanyak 24 ekor umur 1 bulan dengan berat badan 20-30 gram, dibagi menjadi 6 kelompok: kontrol negatif, kontrol positif, kontrol metformin, dan kelompok perlakuan ekstrak etanol biji Cucurbita moschata dosis 180, 360 dan 720 mg/kg BB diberikan secara sonde oral selama 14 hari. Pengamatan terhadap kadar malondehaldehid. Hasil penelitian pemberian ekstrak etanol biji Cucurbita moschata pada semua dosis kelompok perlakuan dapat menurunkan kadar malondehaldehid (Kruskal Wallis p 0,04 < 0,05), sedangkan dosis yang lebih efektif sebanyak 360 mg/kgBB. Kesimpulan semua dosis kelompok perlakuan dapat menurunkan kadar malondehaldehid, sedangkan dosis yang lebih efektif sebanyak 360 mg/kgBB. Kata kunci : Cucurbita moschata, malondehaldehid, diabetes Abstract Everybody expects of being healthy, but health must be maintained to avoid excessive free radical exposure since it will trigger the onset of diabetes mellitus that is accompanied by an increase in the malondialdehyde level. Prevention of excessive free radicals can be done by utilizing Cucurbita moschata seeds. Antioxidants in Cucurbita moschata seeds play a role in overcoming and preventing oxidative stress in people with diabetes mellitus. The study aimed to determine the potential of ethanol extract of Cucurbita moschata seeds on the malondialdehyde level in diabetic mice. This study applied an experimental research method with a posttest control group design. The subjects were 24 male mice aged one month with a bodyweight of 20-30 grams and were divided into six groups: negative control, positive control, metformin control, and treatment groups of ethanol extract Cucurbita moschata seed doses of 180, 360, and 720 mg/kgBW given orally for 14 days. The results of the study showed that ethanol extract of Cucurbita moschata seeds on all treatment doses could reduce the malondialdehyde level (Kruskal Wallis p 0.04 <0.05), but the most effective dose was 360 mg/kgBW. In short, all treatment doses can reduce the malondialdehyde level, but the most effective dose is 360 mg/kgBW. Keywords: Cucurbita moschata, malondialdehyde , diabetes","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"20-30"},"PeriodicalIF":0.0,"publicationDate":"2020-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48486451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-29DOI: 10.21776/ub.ijhn.2020.007.01.4
J. Februhartanty, S. Muslimatun, A. Shankar, Nelden Djakababa, R. Suradi
Abstract We explored paternal roles in timely breastfeeding initiation and exclusive breastfeeding practices in Jakarta using a mixed-methods approach in sequence of focus group discussions (FGDs – phase 1) and a quantitative survey (phase 2). The study population was parents with infants aged below 6 months. Data on paternal roles, maternal attributes, and breastfeeding practices were collected from 43 purposively selected parents in phase 1 and 536 couples in phase 2. FGDs provided insights to finalize the questionnaire for the survey. Nine paternal roles were identified: 1-accompanying the mother during antenatal and postnatal visits, 2-suggesting places for health checkups and delivery, 3-seeking information about child nutrition, 4-accompanying the mother during delivery, 5-facilitating psychological support of the mother, 6-childcare involvement, 7-engagement in childcare discussions, 8-involvement in decisions about infant feeding mode, and 9-enthusiasm for fatherhood. Roles 3 (aOR=1.65; 95%CI=1.07 to 2.54) and 9 (1.59; 1.04-2.44) were positively associated with timely initiation of breastfeeding. Role 8 was positively associated with exclusive breastfeeding (1.69; 1.10-2.60), but roles 2 (0.49; 0.32-0.76) and 5 (0.97; 0.41-0.64) were negatively associated with exclusive breastfeeding. Fathers played roles in breastfeeding practices under study. Fathers need a tailored breastfeeding promotion to stimulate necessary support for breastfeeding mothers. Keywords: initiation of breastfeeding, exclusive breastfeeding, fathers, mixed-methods approach, Indonesia
{"title":"Paternal Roles in Breastfeeding in Jakarta, Indonesia: A Mixed-method Approach","authors":"J. Februhartanty, S. Muslimatun, A. Shankar, Nelden Djakababa, R. Suradi","doi":"10.21776/ub.ijhn.2020.007.01.4","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.4","url":null,"abstract":"Abstract We explored paternal roles in timely breastfeeding initiation and exclusive breastfeeding practices in Jakarta using a mixed-methods approach in sequence of focus group discussions (FGDs – phase 1) and a quantitative survey (phase 2). The study population was parents with infants aged below 6 months. Data on paternal roles, maternal attributes, and breastfeeding practices were collected from 43 purposively selected parents in phase 1 and 536 couples in phase 2. FGDs provided insights to finalize the questionnaire for the survey. Nine paternal roles were identified: 1-accompanying the mother during antenatal and postnatal visits, 2-suggesting places for health checkups and delivery, 3-seeking information about child nutrition, 4-accompanying the mother during delivery, 5-facilitating psychological support of the mother, 6-childcare involvement, 7-engagement in childcare discussions, 8-involvement in decisions about infant feeding mode, and 9-enthusiasm for fatherhood. Roles 3 (aOR=1.65; 95%CI=1.07 to 2.54) and 9 (1.59; 1.04-2.44) were positively associated with timely initiation of breastfeeding. Role 8 was positively associated with exclusive breastfeeding (1.69; 1.10-2.60), but roles 2 (0.49; 0.32-0.76) and 5 (0.97; 0.41-0.64) were negatively associated with exclusive breastfeeding. Fathers played roles in breastfeeding practices under study. Fathers need a tailored breastfeeding promotion to stimulate necessary support for breastfeeding mothers. Keywords: initiation of breastfeeding, exclusive breastfeeding, fathers, mixed-methods approach, Indonesia","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"31-43"},"PeriodicalIF":0.0,"publicationDate":"2020-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44333617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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