Russian Journal of General Chemistry最新文献

A method was developed for obtaining positional isomers—2-[6-aryl-4-trifluoromethyl-3-cyanopyridin-2(1H)-ylidene]malononitriles and 2-[4-aryl-6-trifluoromethyl-3-cyanopyridin-2(1H)-ylidene]malononitriles, which differ in the opposite positioning of the aryl and trifluoromethyl substituents. These compounds exhibit photoluminescence in solutions ranging from the violet to the yellow region of the visible spectrum (λ_em^max = 418–577 nm). The strongest photoluminescence was observed in low-polarity solvents, where the quantum yield of photoluminescence reached 46%. It was shown that a basic medium leads to a significant red shift due to the formation of the anionic form.

Molecular sensors are a new and rapidly developing tool in biochemical research. They enable the exploration of biochemical reaction mechanisms and the prompt diagnosis of pathological conditions. Fluorescent dyes based on boron dipyrromethene (BODIPY) complexes are widely used as molecular sensors. This study demonstrates the potential for characterizing processes occurring in the blood plasma coagulation system across different age groups, including patients with acute myocardial infarction. In elderly individuals, compared to younger people, the blood clotting process begins earlier, the formation of fibrin slows down, and thrombin activity decreases. This technique can detect an increase in thrombin activity accompanied by a higher concentration of fibrinogen in patients with heart pathology. In such cases, blood clotting starts later and lasts longer. These changes in indicators can be attributed to the emergency administration of heparin. On the one hand, heparin prevents the enlargement of a blood clot; on the other, it reduces the activity of the prothrombinase complex, which is beneficial for patients with myocardial infarction. Further observation of blood clotting reveals alterations in fibrin structure, leading to a lengthened stabilization time. Thus, the results obtained in this study are consistent with the literature. The presented method is applicable both for physiological studies of the coagulation process and in clinical practice. Additionally, this method can be used for the kinetic evaluation of anticoagulants’ effects on hemostasis factor activity.

This article examines the production volumes of diesel fuel categorized by environmental safety classes (second, third, fourth, and fifth). The authors analyzed the trends in diesel fuel production volumes in the Russian Federation from 2011 to 2019. They identified mathematical models that effectively describe these trends. A forecast for these indicators was also made for 2024. The calculations suggest that the volume of diesel fuel meeting the fifth environmental safety class is expected to increase by 17.9% compared to 2019.

Eleven copper(I) halide complexes [CuX(CNR)₃] (X = Cl, Br; R = C₆H₃-2,6-Cl₂, C₆H₃-2-Cl-6-Me, C₆H₃-2,6-Br₂, C₆H₃-2-Br-6-Me; X = I, R = C₆H₃-2,6-Cl₂, C₆H₃-2-Cl-6-Me, C₆H₃-2-Br-6-Me) bearing halogen-functionalized aromatic isocyanide ligands were synthesized. The compounds were characterized by atomic emission spectroscopy (Cu), IR, ¹H NMR spectroscopy and high-resolution mass spectrometry. The structure of nine compounds was determined by X-ray diffraction. Structural studies allow to reveal that the supramolecular structure of the complexes is based on weak C–H···X (X = Cl, Br, I) interactions and π-stacking of the aromatic rings of isocyanide ligands.

The article presents the results of studying the colorimetric characteristics of dyeing cotton fabrics with natural dyes extracted from various plants native to Tajikistan (Saint-John’s wort, harmel peganum, woad, oriental plane tree bark, barberry root, rhubarb root). The influence of different mordants (MgCl₂, AlCl₃, FeCl₃, FeSО₄, Al₂(SО₄)₂, CuSO₄) on basic color characteristics such as lightness and color saturation of the dyed samples is analyzed. Spectrophotometric studies have established that the most significant changes in color characteristics occur when using iron (III) salts, which aligns with the complexing properties of transition metals and the stability of the complexes they form. The research demonstrates that using various mordants allows for obtaining a wide range of additional colors and shades. In the CIELab color system, the locations of the obtained colors are indicated on the a*, b* color chart, and the color gamuts are constructed.

Novel 1-phenyl(1-thiophen-2-yl)-4-(diphenylphosphoryl)butane-1,3-diones were synthesized by the Claisen-type condensation of 1-(diphenylphosphoryl)propan-2-one with ethyl phenyl(thiophene-2-yl)carboxylates. The tautomeric equilibrium of diketone moiety of phosphine oxides was investigated by ¹H and ¹³C{¹H} NMR spectroscopy. Two species out of five possible tautomers (diketo and mono-enol) were observed in the solution of 1-phenyl(1-thiophen-2-yl)-4-(diphenylphosphoryl)butane-1,3-diones. The major tautomer was the mono-enol form with content 80–90%. Furthermore, the double bond position at C³ atom was determined by ¹³C{¹H} NMR spectroscopy.

A series of new quinoline-thiazolidine-2,4-dione-isoxazole conjugates was synthesized and evaluated for in vitro anticancer potency against two breast cancer cell lines, such as MCF-7, MDA-MB231, and the normal cancer cell line MCF-10 A (breast cell line) using erlotinib as a standard drug. (Z)-3-{[5-(4-Methoxyphenyl)isoxazol-3-yl]methyl}-5-(quinolin-4-ylmethylene)thiazolidine-2,4-dione and (Z)-3-{[5-(3,5-dimethoxyphenyl)isoxazol-3-yl]methyl}-5-(quinolin-4-ylmethylene)thiazolidine-2,4-dione showed higher anticancer activities against two cancer cell lines, with IC₅₀ ranging from 3.10 ± 0.43, 2.01 ± 0.03, 3.04 ± 0.05, and 2.00 ± 0.07 μM. Furthermore, (Z)-3-{[5-(4-methoxyphenyl)isoxazol-3-yl]methyl}-5-(quinolin-4-ylmethylene)thiazolidine-2,4-dione, and (Z)-3-{[5-(3,5-dimethoxyphenyl)isoxazol-3-yl]methyl}-5-(quinolin-4-ylmethylene)thiazolidine-2,4-dione displayed more inhibitory activity over tyrosine kinase EGFR when compared with the standard erlotinib.

The model described pertains to non-ferrous metal metallurgy, specifically the electrochemical synthesis of high-purity, fine-dispersed zinc powders. The properties of zinc powders obtained via electrolytic methods in a 10% sodium hydroxide solution, after leaching the active mass of spent manganese-zinc chemical current sources, have been studied. Cathodic polarization curves during the electrochemical deposition of zinc powders were examined both in steady-state mode and under an ultrasonic field, with the optimal current density set at 5 A/dm². Zinc powder electroextraction was conducted in both stationary mode with a current density of 5 A/dm² and in an ultrasonic field with a current density of 7 A/dm². Optimal parameters such as electrolytic cell voltage, zinc Zn²⁺ ion concentration, and current yield were monitored and determined during electrolysis. Based on the current yield and the concentration of Zn²⁺ ions in the solution, the ultrasonic deposition mode proved to be preferable, with a current yield of 42% compared to 30% in the stationary mode. The zinc powders obtained were examined using an electron microscope, revealing granules of high dispersion. These powders exhibit anticorrosive, electrical, and thermoelectric properties. The physical and chemical characteristics of these zinc powders, derived from the leaching of active masses in spent manganese-zinc current sources, make them suitable for creating light-emitting devices such as lasers and LEDs. Additionally, when alloyed with rare metals, these powders' semiconductor properties broaden their application in the electronics industry.

An approach to the stereoselective oxidation of 5,6-bis(hydroxymethyl)-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine and 5,6-bis(hydroxymethyl)-2,4-dimethyl-3-hydroxypyridine with manganese dioxide has been developed, intermediates and by-products have been isolated. In solutions, pyridoxine derivatives containing a carbaldehyde group exist in cyclic hemiacetal and open hydroxyaldehyde forms.